CN106509434B - Chinese herbal medicine feed additive for preventing and treating piglet diarrhea - Google Patents
Chinese herbal medicine feed additive for preventing and treating piglet diarrhea Download PDFInfo
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Abstract
The invention belongs to the technical field of piglet feed, and particularly relates to a Chinese herbal medicine feed additive for preventing and treating piglet diarrhea and a preparation method thereof. The preparation method comprises the following steps: sequentially extracting mume fructus, fructus Amomi and pericarpium Citri Tangerinae with 60-90% ethanol and drinking water under reflux, mixing extractive solutions, mixing with water extracts of herba Acalyphae, radix Berberidis kunmingensis, Massa Medicata Fermentata, rhizoma Dioscoreae, radix Codonopsis, Atractylodis rhizoma, radix Pseudostellariae, radix astragali, fructus crataegi and Glycyrrhrizae radix, concentrating, drying to obtain dry powder, mixing with pulverized fructus Hordei Germinatus preparata powder and Poria powder, and packaging. The Chinese herbal medicine feed additive provided by the invention is scientific and reasonable in raw materials, strong in operability in the preparation process, good in palatability, and capable of effectively preventing diarrhea of piglets, improving digestion and absorption capacity of piglets, enhancing immunity and anti-stress capacity, improving survival rate of piglets and promoting growth of piglets.
Description
Technical Field
The invention belongs to the technical field of piglet feed, and particularly relates to a Chinese herbal medicine feed additive for preventing and treating piglet diarrhea and a preparation method thereof.
Background
The Chinese herbal medicine is a natural green plant, has two attributes of nutrition and medicine, has the functions of promoting the growth and development of animals, improving the utilization rate of feed and the like, and is already applied to the raising of pork pigs, but the traditional Chinese herbal medicine feed additive mainly aims at the aspects of the production performance and the immunity of the pigs, but aims at the aspects of preventing and treating piglet diarrhea, and has an unobvious effect; the diarrhea is one of piglet diseases which frequently occur in recent years, the growth and even death of piglets are seriously influenced, and great economic loss is caused to breeding enterprises or farmers; meanwhile, the prescription of a plurality of Chinese herbal medicine feed additives is not scientific and rigorous enough, the palatability is poor, the Chinese herbal medicine feed additives are mostly powder prepared by drying, crushing and mixing, the preparation process is laggard, and the addition amount is too large, so that the popularization and the application of the Chinese herbal medicine feed additives are restricted.
Disclosure of Invention
The invention aims to provide the Chinese herbal medicine feed additive for preventing and treating the diarrhea of the piglets and the preparation method thereof, the raw materials are scientific and reasonable, the operability of the preparation process is strong, the palatability of the prepared additive is good, the occurrence of the diarrhea of the piglets can be effectively prevented, the digestion and absorption capacity of the piglets is improved, the immunity and the anti-stress capacity are enhanced, the survival rate of the piglets is improved, and the growth of the piglets is promoted.
The invention relates to a Chinese herbal medicine feed additive for piglets, which comprises the following raw material components in parts by weight: 5-15 parts of acalypha australis, 5-15 parts of radix berberidis, 5-15 parts of dark plum fruit, 5-15 parts of medicated leaven, 4-10 parts of Chinese yam, 4-10 parts of codonopsis pilosula, 4-10 parts of poria cocos, 4-10 parts of bighead atractylodes rhizome, 3-9 parts of radix pseudostellariae, 3-9 parts of astragalus membranaceus, 3-9 parts of pericarpium citri reticulatae, 2-8 parts of fried malt, 2-8 parts of hawthorn, 1-5 parts of fructus amomi and 1-5 parts of liquorice.
The preparation method of the Chinese herbal medicine feed additive comprises the following steps: sequentially extracting mume fructus, fructus Amomi and pericarpium Citri Tangerinae with 60-90% ethanol and drinking water under reflux, mixing extractive solutions, mixing with water extracts of herba Acalyphae, radix Berberidis kunmingensis, Massa Medicata Fermentata, rhizoma Dioscoreae, radix Codonopsis, Atractylodis rhizoma, radix Pseudostellariae, radix astragali, fructus crataegi and Glycyrrhrizae radix, concentrating, drying to obtain dry powder, mixing with pulverized fructus Hordei Germinatus preparata powder and Poria powder, and packaging.
The method comprises the following specific steps:
(1) and crushing: pulverizing parched fructus Hordei Germinatus and Poria, and sieving with 80-160 mesh sieve;
(2) and leaching: extracting mume fructus, fructus Amomi and pericarpium Citri Tangerinae with 4-8 times weight volume of 60-90% ethanol under reflux for 0.5-1.5 hr, collecting ethanol extractive solution a, extracting with 4-8 times weight volume of drinking water under reflux for 2-3 times at 85-95 deg.C for 0.5-1.5 hr each time, and collecting extractive solution b; adding herba Acalyphae, radix Berberidis kunmingensis, Massa Medicata Fermentata, rhizoma Dioscoreae, radix Codonopsis, Atractylodis rhizoma, radix Pseudostellariae, radix astragali, fructus crataegi and Glycyrrhrizae radix into 4-8 times of drinking water, decocting for 2-3 times, each time for 0.5-1.5 hr, and collecting extractive solution c at 85-95 deg.C;
(3) and (3) concentrating, namely mixing the extracting solutions a, b and c obtained in the step ⑵, and concentrating to obtain a concentrated solution with the relative density of 1.05-1.10 at the temperature of 40-60 ℃;
(4) and (3) spray drying: adding dextrin accounting for 1-3% of the weight of the concentrated solution, uniformly stirring, and carrying out spray drying;
(5) and (3) preparation: adding 0.02-0.05% of CMC and 0.03-0.05% of phospholipid by weight ratio into the dried powder after spray drying, and uniformly mixing;
(6) and sieving: sieving with 80-160 mesh sieve;
(7) and mixing: and (3) uniformly mixing the dry powder sieved in the step (6) with the fried malt powder and the tuckahoe powder obtained in the step (1), and packaging.
The application of the Chinese herbal medicine feed additive of the invention is as follows: the additive is added into the daily feed (powder) of the piglets according to the weight ratio of 0.3-1.0 percent of the feeding amount of the piglet feed, the feed is carried out after the mixture is evenly stirred, the additive can also be added into the basal ration formula of the piglets in the form of premix and granulated into granulated feed for feeding, and the Chinese herbal medicine feed additive is continuously added into the piglets from the weaning of the piglets until the piglets grow to about 40 kg.
The invention has the following remarkable advantages:
(1) the preparation method adopts the methods of extraction, concentration and spraying, can achieve the purposes of micro-quantization and high efficiency of the feed additive, is convenient to produce, transport and feed, meets the requirements of modern pork pig large-scale breeding, adopts the extraction method of firstly extracting alcohol and then extracting water for the medicinal materials such as dark plum fruit, villous amomum fruit, tangerine peel and the like, ensures that the fat-soluble components and the water-soluble components of the medicinal materials are extracted together, and furthest ensures the efficacy of the Chinese herbal medicine feed additive.
(2) The Chinese herbal medicine feed additive has scientific formula and reasonable matching, the acalypha australis and the radix berberidis in the Chinese herbal medicine feed additive formula respectively have the effects of clearing heat and removing toxicity, removing food retention and stopping dysentery and the like in different degrees, and the synergistic application has good effects of preventing and treating piglet diarrhea and simultaneously has good anti-inflammatory, bacteriostatic and antiviral effects; the dark plum, the medicated leaven, the largehead atractylodes rhizome, the villous amomum fruit, the pilose asiabell root, the fried malt and the hawthorn fruit have the efficacies of strengthening spleen and stimulating appetite, eliminating dampness and promoting diuresis, promoting digestion and relieving flatulence, eliminating stagnation and the like in different degrees respectively, and have good effects of preventing and treating various symptoms caused by digestive tract system diseases such as diarrhea by synergistic application; the astragalus, the bighead atractylodes rhizome, the poria cocos, the Chinese yam, the radix pseudostellariae, the fried malt, the dried orange peel, the hawthorn and the liquorice respectively have the effects of tonifying middle-jiao and Qi, soothing nerves and calming the heart to different degrees, and have the effects of promoting growth, resisting stress and improving immunity by synergistic application.
(3) The invention has obvious prevention effect on the diarrhea of piglets, and the diarrhea incidence rate is reduced by 54.2-75.3% compared with that of a control group (without adding medicaments in the conventional way); meanwhile, the invention has obvious improvement effect on the growth performance and immunity of piglets, and compared with a control group, the feed conversion ratio is reduced by 10.2-23.5%, the content of immunoglobulin IgA in piglet serum is improved by 12.0-20.8%, the content of immunoglobulin IgM is improved by 13.5-24.3%, and the content of immunoglobulin IgG is improved by 9.8-13.2%.
(4) The invention has obvious therapeutic action on the diarrhea of piglets, the total effective rate of treatment reaches 72.5-88.4%, and the curative effect is similar to that of western medicine group (adding bacitracin zinc and colistin sulfate), the growth performance of piglets can be improved while the treatment is carried out, and compared with western medicine group, the feed-meat ratio is reduced by 8.5-14.0%.
Detailed Description
The present invention will be further described with reference to a few specific examples thereof, but the present invention is not limited thereto.
Example 1
A Chinese herbal medicine feed additive for preventing and treating piglet diarrhea comprises the following raw material components in parts by weight: 15 parts of acalypha australis, 15 parts of radix berberidis, 5 parts of dark plum, 5 parts of medicated leaven, 10 parts of Chinese yam, 10 parts of codonopsis pilosula, 4 parts of poria cocos, 4 parts of bighead atractylodes rhizome, 9 parts of radix pseudostellariae, 6 parts of astragalus membranaceus, 3 parts of dried orange peel, 8 parts of fried malt, 2 parts of hawthorn, 5 parts of fructus amomi and 1 part of liquorice. (Total 100 parts)
The preparation method of the Chinese herbal medicine feed additive comprises the following specific steps:
(1) crushing: pulverizing parched fructus Hordei Germinatus and Poria, and sieving with 80 mesh sieve;
(2) leaching: extracting mume fructus, fructus Amomi and pericarpium Citri Tangerinae with 8 times of weight and volume of 60% ethanol under reflux for 1.5 hr, collecting ethanol extractive solution a, extracting with 8 times of weight and volume of medicinal drinking water under reflux for 2 times at 85 deg.C for 1.5 hr each time, and collecting extractive solution b; adding herba Acalyphae, radix Berberidis kunmingensis, Massa Medicata Fermentata, rhizoma Dioscoreae, radix Codonopsis, Atractylodis rhizoma, radix Pseudostellariae, radix astragali, fructus crataegi and Glycyrrhrizae radix into 8 times of drinking water, decocting for 2 times, each for 1.5 hr, and collecting extractive solution c at 85 deg.C;
(3) concentration: mixing the extracting solutions a, b and c in the step (2), and concentrating to obtain a concentrated solution with the relative density of 1.05 at 40 ℃;
(4) spray drying: adding dextrin accounting for 1 percent of the weight of the concentrated solution into the concentrated solution, uniformly stirring, and carrying out spray drying;
(5) preparation: adding 0.02 wt% of CMC and 0.05 wt% of phospholipid into the spray-dried dry powder, and mixing uniformly;
(6) sieving: sieving with 80 mesh sieve;
(7) mixing: and (3) uniformly mixing the dry powder sieved in the step (6) with the fried malt powder and the tuckahoe powder obtained in the step (1), and packaging.
The application of the Chinese herbal medicine feed additive comprises the following steps: the Chinese herbal medicine feed additive is added into the daily feed of the piglets according to the proportion that the weight ratio of the feed amount of the piglets is 0.3 percent, the feed is carried out after the mixture is evenly stirred, and the Chinese herbal medicine feed additive is continuously added into the piglets from the weaning of the piglets till the piglets grow to 40 kg.
Example 2
A Chinese herbal medicine feed additive for preventing and treating piglet diarrhea comprises the following raw material components in parts by weight: 10 parts of acalypha australis, 10 parts of radix berberidis, 10 parts of dark plum, 10 parts of medicated leaven, 7 parts of Chinese yam, 7 parts of codonopsis pilosula, 7 parts of poria cocos, 7 parts of bighead atractylodes rhizome, 6 parts of radix pseudostellariae, 9 parts of astragalus membranaceus, 3 parts of dried orange peel, 4 parts of fried malt, 4 parts of hawthorn, 3 parts of fructus amomi and 3 parts of liquorice. (Total 100 parts)
The preparation method of the Chinese herbal medicine feed additive comprises the following specific steps:
(1) crushing: pulverizing parched fructus Hordei Germinatus and Poria, and sieving with 120 mesh sieve;
(2) leaching: extracting mume fructus, fructus Amomi and pericarpium Citri Tangerinae with 80% ethanol with mass concentration of 6 times of the weight and volume of the medicine under reflux for 1.0 hr, collecting ethanol extractive solution a, extracting with drinking water with 6 times of the weight and volume of the medicine under reflux for 2 times at 90 deg.C for 1.0 hr each time, and collecting extractive solution b; adding herba Acalyphae, radix Berberidis kunmingensis, Massa Medicata Fermentata, rhizoma Dioscoreae, radix Codonopsis, Atractylodis rhizoma, radix Pseudostellariae, radix astragali, fructus crataegi and Glycyrrhrizae radix into drinking water 6 times of the weight and volume of the medicines, decocting for 2 times, each time for 1.0 hr, and collecting extractive solution c at 90 deg.C;
(3) concentration: mixing the extracting solutions a, b and c in the step (2), and concentrating to obtain a concentrated solution with the relative density of 1.08 at 50 ℃;
(4) spray drying: adding dextrin accounting for 2 percent of the weight of the concentrated solution into the concentrated solution, uniformly stirring, and carrying out spray drying;
(5) preparation: adding 0.03 weight percent of CMC and 0.04 weight percent of phospholipid into the dried powder after spray drying, and uniformly mixing;
(6) sieving: sieving with 120 mesh sieve;
(7) mixing: and (3) uniformly mixing the dry powder sieved in the step (6) with the fried malt powder and the tuckahoe powder obtained in the step (1), and packaging.
The application of the Chinese herbal medicine feed additive comprises the following steps: the Chinese herbal medicine feed additive is added into a basal ration formula of piglets in the form of premix and granulated into pellet feed for feeding, the adding amount of the Chinese herbal medicine feed additive accounts for 1.0 percent of the weight ratio, and the Chinese herbal medicine feed additive is uninterruptedly added to the piglets from the weaning of the piglets to the growth of 40 kg.
Example 3
A Chinese herbal medicine feed additive for preventing and treating piglet diarrhea comprises the following raw material components in parts by weight: the traditional Chinese medicine composition comprises, by weight, 5 parts of acalypha australis, 5 parts of radix berberidis, 15 parts of dark plum fruit, 15 parts of medicated leaven, 4 parts of Chinese yam, 4 parts of codonopsis pilosula, 10 parts of poria cocos, 10 parts of bighead atractylodes rhizome, 3 parts of radix pseudostellariae, 6 parts of astragalus membranaceus, 9 parts of dried orange peel, 1 part of fried malt, 5 parts of hawthorn, 1 part of fructus amomi and 5 parts of liquorice.
The preparation method of the Chinese herbal medicine feed additive comprises the following specific steps:
(1) crushing: pulverizing parched fructus Hordei Germinatus and Poria, and sieving with 160 mesh sieve;
(2) leaching: extracting mume fructus, fructus Amomi and pericarpium Citri Tangerinae with 90% ethanol with mass concentration 4 times of the weight and volume of the medicine under reflux for 0.5 hr, collecting ethanol extractive solution a, extracting with drinking water 4 times of the weight and volume of the medicine under reflux for 3 times at 95 deg.C for 0.5 hr each time, and collecting extractive solution b; adding herba Acalyphae, radix Berberidis kunmingensis, Massa Medicata Fermentata, rhizoma Dioscoreae, radix Codonopsis, Atractylodis rhizoma, radix Pseudostellariae, radix astragali, fructus crataegi and Glycyrrhrizae radix into 4 times of drinking water, decocting for 3 times, each time for 0.5 hr, and collecting extractive solution c at 95 deg.C;
(3) concentration: mixing the extracting solutions a, b and c in the step (2), and concentrating to obtain a concentrated solution with the relative density of 1.10 at 60 ℃;
(4) spray drying: adding dextrin which accounts for 3 percent of the weight of the concentrated solution into the concentrated solution, uniformly stirring, and carrying out spray drying;
(5) preparation: adding 0.05% of CMC and 0.03% of phospholipid by weight into the dried powder after spray drying, and uniformly mixing;
(6) sieving: sieving with 200 mesh sieve;
(7) mixing: and (3) uniformly mixing the dry powder sieved in the step (6) with the fried malt powder and the tuckahoe powder obtained in the step (1), and packaging.
The application of the Chinese herbal medicine feed additive comprises the following steps: the Chinese herbal medicine feed additive is added into the daily feed of the piglets according to the proportion that the weight ratio of the feed amount of the piglets is 1.0 percent, the feed is carried out after the mixture is evenly stirred, and the Chinese herbal medicine feed additive is continuously added into the piglets from the weaning of the piglets till the piglets grow to 40 kg.
Effects of the invention
The invention has obvious prevention effect on the diarrhea of piglets, and the diarrhea incidence rate is reduced by 54.2-75.3% compared with that of a control group (without adding medicaments in the conventional way); meanwhile, the invention has obvious improvement effect on the growth performance and immunity of piglets, and compared with a control group, the feed conversion ratio is reduced by 10.2-23.5%, the content of immunoglobulin IgA in piglet serum is improved by 12.0-20.8%, the content of immunoglobulin IgM is improved by 13.5-24.3%, and the content of immunoglobulin IgG is improved by 9.8-13.2%.
The invention has obvious therapeutic action on the diarrhea of piglets, the total effective rate of treatment reaches 72.5-88.4%, and the curative effect is similar to that of western medicine group (adding bacitracin zinc and colistin sulfate), the growth performance of piglets can be improved while the treatment is carried out, and compared with western medicine group, the feed-meat ratio is reduced by 8.5-14.0%.
The above description is only a preferred embodiment of the present invention, and all equivalent changes and modifications made in accordance with the claims of the present invention should be covered by the present invention.
Claims (3)
1. The Chinese herbal medicine feed additive for preventing and treating piglet diarrhea is characterized by comprising the following raw material components in parts by weight: 5-15 parts of acalypha australis, 5-15 parts of radix berberidis, 5-15 parts of dark plum fruit, 5-15 parts of medicated leaven, 4-10 parts of Chinese yam, 4-10 parts of codonopsis pilosula, 4-10 parts of poria cocos, 4-10 parts of bighead atractylodes rhizome, 3-9 parts of radix pseudostellariae, 3-9 parts of astragalus membranaceus, 3-9 parts of pericarpium citri reticulatae, 2-8 parts of fried malt, 2-8 parts of hawthorn, 1-5 parts of fructus amomi and 1-5 parts of liquorice.
2. A method for preparing the Chinese herbal medicine feed additive of claim 1, which is characterized in that: the preparation method comprises the following steps: sequentially extracting mume fructus, fructus Amomi and pericarpium Citri Tangerinae with 60-90% ethanol and drinking water under reflux, mixing extractive solutions, mixing with water extracts of herba Acalyphae, radix Berberidis kunmingensis, Massa Medicata Fermentata, rhizoma Dioscoreae, radix Codonopsis, Atractylodis rhizoma, radix Pseudostellariae, radix astragali, fructus crataegi and Glycyrrhrizae radix, concentrating, drying to obtain dry powder, mixing with pulverized fructus Hordei Germinatus preparata powder and Poria powder, and packaging.
3. The method for preparing the Chinese herbal medicine feed additive according to claim 2, which is characterized in that: the method comprises the following specific steps:
(1) crushing: pulverizing parched fructus Hordei Germinatus and Poria, and sieving with 80-160 mesh sieve;
(2) leaching: extracting mume fructus, fructus Amomi and pericarpium Citri Tangerinae with 60% -90% ethanol with weight concentration of 4-8 times of the weight volume of the medicine under reflux for 0.5-1.5 hr, collecting ethanol extractive solution a, extracting with drinking water with weight volume of 4-8 times of the weight volume of the medicine under reflux for 2-3 times at 85-95 deg.C for 0.5-1.5 hr each time, and collecting extractive solution b; adding herba Acalyphae, radix Berberidis kunmingensis, Massa Medicata Fermentata, rhizoma Dioscoreae, radix Codonopsis, Atractylodis rhizoma, radix Pseudostellariae, radix astragali, fructus crataegi and Glycyrrhrizae radix into drinking water 4-8 times of the weight volume of the medicine, decocting for 2-3 times, each time for 0.5-1.5 hr, and collecting extractive solution c at 85-95 deg.C;
(3) concentration: mixing the extracting solutions a, b and c in the step (2), and concentrating to obtain a concentrated solution with the relative density of 1.05-1.10 at the temperature of 40-60 ℃;
(4) spray drying: adding dextrin which accounts for 1 to 3 weight percent of the concentrated solution into the concentrated solution, uniformly stirring, and carrying out spray drying;
(5) preparation: adding 0.02-0.05% of CMC and 0.03-0.05% of phospholipid by weight ratio into the dried powder after spray drying, and uniformly mixing;
(6) sieving: sieving with 80-160 mesh sieve;
(7) mixing: and (3) uniformly mixing the dry powder sieved in the step (6) with the fried malt powder and the tuckahoe powder obtained in the step (1), and packaging.
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| CN107048032A (en) * | 2017-04-28 | 2017-08-18 | 铜仁市万山区绿涛牧业有限公司 | A kind of pig starter feed |
| CN107594179A (en) * | 2017-11-07 | 2018-01-19 | 广州美豆生物技术有限公司 | A kind of modified form of combination expanded soybean and emulsifying agent easily absorbs feed and preparation method thereof |
| CN107712327A (en) * | 2017-11-17 | 2018-02-23 | 广西***春福林家庭农场 | A kind of health care sheep feed additive |
| CN108785368A (en) * | 2018-08-29 | 2018-11-13 | 江苏食品药品职业技术学院 | Treat " four wormwood artemisias " feed addictive and the preparation method and application thereof of grice diarrhoea |
| CN109497286B (en) * | 2018-12-24 | 2022-05-17 | 福建省农业科学院农业生态研究所 | Chinese herbal medicine feed additive for promoting growth of piglets and preparation method thereof |
| CN114246268A (en) * | 2021-12-27 | 2022-03-29 | 清远一生自然生物研究院有限公司 | Production method of mixed feed additive for preventing piglet diarrhea |
| CN115644321B (en) * | 2022-11-15 | 2023-03-03 | 潍坊天普阳光饲料科技有限公司 | Feed additive for preventing and treating pig diarrhea and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102894192A (en) * | 2012-09-05 | 2013-01-30 | 河北科技师范学院 | Chinese herbal feed additive for piglet diarrhea prevention and treatment |
| CN105341415A (en) * | 2015-11-25 | 2016-02-24 | 广州聚注专利研发有限公司 | Chinese herbal medicine additive for pig feed and preparation method of Chinese herbal medicine additive |
| CN105614113A (en) * | 2016-03-10 | 2016-06-01 | 徐杰 | Piglet anti-diarrhea compound Chinese herbal medicine feed and preparing method thereof |
| CN105746898A (en) * | 2016-03-09 | 2016-07-13 | 广州格雷特生物科技有限公司 | Chinese herbal medicine feed additive with Folium Callicarpae Nudiflorae and preparation method and application thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095616A (en) * | 1993-10-24 | 1994-11-30 | 李伟 | Fructus Mali Asiaticae diarrhea and preparation method thereof |
| CN101905014B (en) * | 2010-08-03 | 2011-08-31 | 中国农业科学院上海兽医研究所 | Traditional Chinese medicine compound composition for treating diarrhea of weaned piglets |
| KR101413184B1 (en) * | 2012-06-07 | 2014-06-27 | 경상대학교산학협력단 | Use of salts and herbal extracts mixture for the treatment of domestic animals and poultry |
-
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102894192A (en) * | 2012-09-05 | 2013-01-30 | 河北科技师范学院 | Chinese herbal feed additive for piglet diarrhea prevention and treatment |
| CN105341415A (en) * | 2015-11-25 | 2016-02-24 | 广州聚注专利研发有限公司 | Chinese herbal medicine additive for pig feed and preparation method of Chinese herbal medicine additive |
| CN105746898A (en) * | 2016-03-09 | 2016-07-13 | 广州格雷特生物科技有限公司 | Chinese herbal medicine feed additive with Folium Callicarpae Nudiflorae and preparation method and application thereof |
| CN105614113A (en) * | 2016-03-10 | 2016-06-01 | 徐杰 | Piglet anti-diarrhea compound Chinese herbal medicine feed and preparing method thereof |
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