CN106492343A - Metastasis of cancer transdermal medicine for treating device - Google Patents
Metastasis of cancer transdermal medicine for treating device Download PDFInfo
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- CN106492343A CN106492343A CN201611119507.4A CN201611119507A CN106492343A CN 106492343 A CN106492343 A CN 106492343A CN 201611119507 A CN201611119507 A CN 201611119507A CN 106492343 A CN106492343 A CN 106492343A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H7/00—Devices for suction-kneading massage; Devices for massaging the skin by rubbing or brushing not otherwise provided for
- A61H7/007—Kneading
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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Abstract
The metastasis of cancer transdermal medicine for treating device of the principle development that rubbed according to traditional Chinese medical science cream of the invention, it is made up of casing, motor, small friction head, safety pad, coarse friction cloth, forward and reverse speed-regulating switch, fluorouracil topical agent, by improving crushing strength and heat speed, chemotherapeutics Transdermal absorption is promoted to produce curative effect in tissue deep and whole body, local chemotherapy and systemic chemotherapy are carried out to solid carcinoma and metastasis of cancer, and reduces side effect.Kill cancer cell based on the stage, first former carninomatosis stove portion and around, metastatic lesion portion and surrounding, Lymph Node Metastasis position and hematogenous metastasis position, coat fluorouracil topical agent, the therapeutic equipment of hand-held high-speed rotation extruding sliding friction carries out the wholistic therapy that cutaneous penetration is killed based on cancer cell, recovers supplemented by function, then rotation direction and rotating speed are adjusted, hand-held slowly run rub the therapeutic equipment of static friction, above-mentioned position carry out recovering deep tissues muscle functions promote based on drug absorption, the wholistic therapy supplemented by cutaneous penetration.
Description
Technical field
The invention belongs to medicine equipment, say that being belonging to massage and cutaneous penetration chemotherapy is combined as a whole treatment cancer in more detail
The medicine equipment of transfer.
Technical background
Modern medicine is placed on early discovery the hope for curing cancer, on early treatment, but cannot cure after metastasis of cancer, cancer
Disease patients with terminal 90% dies from metastasis of cancer.Since the nineties in 20th century, in view of recurrence rate, the rate of transform are still very high after cancer operation,
In order to prevent postoperative recurrence, transfer, start to employ postoperative serial NACT, NACT means are mainly systemic vein
Treat, but its result not fully up to expectations, chemotherapy is limited to solid carcinoma therapeutic effect, and many patient's adjuvant chemotherapy of patients fail to hinder
Only recur and shift.According to《Treatment of cancer new ideas and new method》Page 58, page 59, page 65, described in author Xu Ze：Drip in vein
During note systemic chemotherapy, the chemotherapeutic fluorouracil entered from drip-feed is 5000mg, after with the distribution of each internal organs whole body, really
Reaching the utilizable fluorouracil in cancer stove position only only has 20mg, i.e., only 0.4% medicine to reach cancer stove and be utilized, its
The chemotherapeutics of remaining 99.6% acts on normal cell and produces bad reaction, makes many patients subject chemotherapy bad anti-
The pain that answers.In view of the blindness of Venous Chemotherapy method of administration, causes dosage increase and bad reaction, so solve
Method is to change systemic vein injection chemotherapy method of administration, using other chemotherapy methods of administration.
The tumour external application chemotherapeutic of prior art：It is mainly used in skin or superficial tumor, but due to skin absorption medicine
Ability is less, needs plus uses transdermal agent, to increase the absorption of medicine.Even if so, curative effect is still limited, and cutaneous penetration receives thing
Rationality matter limit exist be difficult to reach quick-acting, can not be with the deficiency of substantial amounts of drug therapy, can only be used as a kind of auxiliary treatment
Mode.
Content of the invention
It is an object of the invention to, chemotherapy is injected for prior art systemic vein, exist in treating to metastasis of cancer
Curative effect low side effect deficiency that is big and can not curing solid carcinoma, according to tribochemistry principle, there is provided one kind locally can be administered and entirely
The friction transdermal delivery device of body administration, is mutually rubbed with coarse friction cloth by motor belt motor dynamic friction head high-speed rotation, is produced high
Intensity extruding force and frictional heat effect, promote chemotherapeutics to carry out Transdermal absorption chemotherapy.When scribbling the outer skin for controlling chemotherapeutics
At 42-70 DEG C, cuticula produces phase transformation and the gap increasing that softens to skin heating temperature, and high intensity extruding force can be fast through friction cloth
Speed propels the drug through cuticula and enters hypodermis addition blood circulation.Modern science is " in pole to the definition of frictional impact
The power of concentration effect in the very brief time ", (referring to《Friction》Page 24, Science Press).The present invention is to former carninomatosis stove and transfer
Carninomatosis stove topical transdermal administration time is the 10-20 seconds, and reciprocating along Lymph Node Metastasis approach and hematogenous metastasis approach carries out transdermal
The drug treatment time is 2 minutes, with treatment time is short, Small side effects, the characteristics of can produce quick-acting.Massage be a kind of with by
Pressure and the coefficient therapy of friction, its action intensity can be characterized with normal pressure and friction frequency.Pressure area is little, presses
Force intensity is big, and friction head velocity of rotation can directly affect the size of frictional force, rub friction be converted into affected part interior energy number,
Mainly determined by rotational frequency.By improving, rotating speed, friction head miniaturization improve friction head shapes to the present invention and extruding chisel edge is long
Degree, improves crushing strength and heat production temperature, can increase medicine in local chemotherapy and reach tissue deep through cutin layer number,
Increase cutaneous penetration area to treat using high amount of drug during systemic chemotherapy.Motor speed is higher, and crushing strength is higher, heat production temperature
Degree is higher faster with heat production speed, and Transdermal absorption medicine is more.The present invention will be extensive to the mechanical energy of pressing friction input human body, heat energy
Multiple functional treatment, carries out globality to disease with collective effect of mutually promoting is treated through skin input chemotherapeutics killing cancer cell
Because treatment, by change method of administration substitute systemic vein inject chemotherapy, improve curative effect reduce side effect treatment solid carcinoma, with gram
The deficiencies in the prior art are taken, the goal of the invention for eliminating and curing is controlled to metastasis of cancer so as to reach.
In order to reach foregoing invention purpose, the present invention is carried out by the following technical programs：A kind of metastasis of cancer transdermal is given
Medicine therapeutic equipment, it be by casing, motor, small friction head, safety pad, coarse friction cloth, fixed cover, forward and reverse speed-regulating switch,
Fluorouracil topical agent is constituted, former carninomatosis stove portion and around, metastatic lesion portion and surrounding, Lymph Node Metastasis position and blood turn
Position is moved, the entirety that the therapeutic equipment of hand-held high-speed rotation is carried out based on cutaneous penetration killing cancer cell, supplemented by recovery function is controlled
Treat, after treatment end, the hand-held therapeutic equipment for slowly running is carried out to recover based on function, cutaneous penetration is killed supplemented by cancer cell
Wholistic therapy；It is characterized in that：Fixed installation motor in casing, 16 small friction heads are arranged on casing into square arrangement
Interior, orientation and casing to handle direction parallel, safety pad is inserted in raised with casing inner plane with bolt after small friction head
Screw is connected and fixed, and motor drives small friction head 10000 turns of high-speed rotations per minute, and small friction Tou Yuan centers are to round edge circle
Radius length fixes a cylinder, and cylinder head plane has a chisel edge raised, and chisel edge projection length is small friction head radius, and thick
Rough friction cloth contact carries out scraping extrusion friction；The stage based on cancer cell is killed in cutaneous penetration, first carninomatosis stove portion and around,
Metastatic lesion portion and surrounding, Lymph Node Metastasis position and hematogenous metastasis position, coat fluorouracil topical agent, hand-held high-speed rotation
Extruding sliding friction therapeutic equipment carry out cutaneous penetration kill cancer cell based on, recover function supplemented by wholistic therapy, then adjust
Whole rotation direction and rotating speed, hand-held slowly run rub the therapeutic equipment of static friction and carry out promoting drug absorption to recover at above-mentioned position
Wholistic therapy based on function, supplemented by cutaneous penetration.
In small friction head, cylinder head plane chisel edge projection is sharp comer, produces slip when high-speed rotation forward and rubs
Wipe, extrude keratoderma and in skin surface frictional heat, promote medicine hypodermis to be entered through cuticula.When by peace
When being mounted in forward and reverse speed-regulating switch of casing handle portions and slowly running backward, chisel edge raises into obtuse angle, can inhale the tight skin of level pressure and produce
Raw static friction, carries out, by generation endogenous heat is rubbed up, promoting deep layer fraction medicine to absorb, and loosening to hypodermis and deep layer position
Muscle stimulates circulation recovery function.Wherein high-speed rotation when based on translation active force, pressure is 0.1 kilogram/square li
Rice, rotating speed is 2000 revs/min, 5000 revs/min, 10000 revs/min of 3 class；When slowly running with pressure at right angle it is
Main, pressure is 0.5-1 kg/cms, and rotating speed is 300 revs/min, 600 revs/min of 2 class.Stitch in coarse friction cloth
There is woven line, rough, can be with increasing friction force, coarse friction cloth is covered on small friction head, and fixed cover rubs coarse
Wiper is fixed on casing.Prior art clinic external used medicine concentration fluorouracil is 1-10%, including malicious drastic and valuable medicine
And 1-10% concentration, pick up minute and a few hours for number with skin time of contact, and in the present invention single location contacts liquid is not
More than 1 minute, it may be considered that it is 1-30% or so to increase concentration.Small friction head circular diameter bottom is fixed with circular projection,
Safety is lined with 16 circular holes, and Circularhole diameter is more than small friction head circular diameter, circular less than small friction head circular diameter bottom
Projection, safety pad are connected and fixed with casing inner plane projection screw with bolt after being inserted in small friction head, to prevent small friction
Head is deviate from high-speed rotation.The circular diameter of small friction head is 0.7 centimetre, and prior art《Therapeutic device for cancer diseases》
Friction head described in (ZL200610069987 8) embodiment is a diameter of 1.5 centimetres, and diameter differs more than 2 times, pressure area
It is 0.49 square centimeter and 2.25 square centimeters, differs 4 times.The present invention by reduce pressure area increase crushing strength, and
Originally installed in the casing of 4 friction heads by 16 small friction heads are filled, increased pressure application point, rotating speed improve 4 times with
Increase efficiency.When friction head area is minimized, extruding chisel edge " one " font, " people " font and "+" font row in prior art
Row can reduce frictional force, into smooth movement, be unfavorable for cutaneous penetration, will not be reduced using radius length chisel edge in high-speed rotation
Frictional force, so as to promote medicine to pass through cuticula.In structure and function interdependence wholistic therapy is carried out, using other treatments
Mode and other configurations also can reach the purpose of the present invention.
The deficiencies in the prior art
Currently, the present situation of metastasis of cancer patient treatment, predominantly systemic vein injection chemotherapy, solid tumor, belly cavity tumor are (such as
The solid malignants such as stomach, intestines, liver, courage, pancreas) also adopt Venous Chemotherapy, adjuvant chemotherapy of patients and perioperative auxiliaryization
Treatment is also adopted by Venous Chemotherapy.Its effect is such as《Anticarcinogen must be used？》(Tianjin science tech publishing house) author's [day]
Nearly rattan is really described：" generally for blood cancer, uterus villioma, carcinoma of testis, anticarcinogen not only has life prolongation effect, also cures
Effect.But for other solid carcinomas such as lung cancer, liver cancer, cancer of the stomach, anticarcinogen is not only invalid, can produce side effect on the contrary.Due to
Anticarcinogen cannot treat solid carcinoma, so brainstrust is typically not by " cancer healing " as index.The real mesh of metastasis of cancer treatment
Be to prolong life, but no matter prior art repeats how many times clinical testing, all cannot confirm anticarcinogen life prolongation effect, such as join
Close embolic chemotherapy and target therapeutic agent (Avastin) life prolongation effect is not proven, it is bright that anticarcinogen occurs can cancer
Aobvious diminution；Still cannot prove that anticarcinogen just has the effect of extending life, the tumour for temporarily reducing can also increase again, anticancer
Doctors can only select the situation for showing tumor regression replacing explanation life prolongation effect.The phenomenon of tumor regression is very rare, pole
Low successful case will pass through certification, can cause greater risk to following patient." so, existing chemotherapy technology is existed to reality
Body cancer can not be cured, it is impossible to prolong life and occur repeatedly and produce the deficiency of side effect.
The treatment principle and feature of the present invention
1st, human body is the entity of structure and function interdependence, lacks one of them, and entity will lose the meaning of presence
Justice, metastasis of cancer treatment are the wholistic therapies combined with recovery function phase by structure antibody Monoclonal, indispensable.Existing chemotherapy technology is being killed
Go out effect is significant in terms of cancer cell, but be a lack of recovering functional treatment, cause patient finally still to die from whole body function pathology.People
Body life movement is machinery, physics, the advanced motion form that combines of chemistry, metastasis of cancer why can causing death, be it
It is a kind of advanced motion form pathology, needs to treat using advanced motion formal technique.Existing chemotherapy technology is a kind of primary fortune
Dynamic form of therapy technology, it is impossible to direct effect is produced to advanced motion form pathology, can only be a kind of adjuvant treatment modality, it is impossible to
Cure solid carcinoma and occur repeatedly with produce side effect.
2 it is characteristic of the invention that：Inherently a kind of health preservation treatment method for recovering bodily fuctions of massotherapy, has
Purpose, selectivity and controllability, when it is combined as a whole collective effect with the chemotherapeutics for killing cancer cell, are a kind of knots
Structure antibody Monoclonal with recover the wholistic therapy mode mutually promoted of function, patient is not in whole body function pathology death factors, energy
Enough extend patient vitals.Because human metabolism function is the basis that life is present, function reduction is not treated, just can not be prolonged
Life.And cancer perilesional function pathology is not treated, the tumour for temporarily reducing can also occur repeatedly because increasing again.Chemotherapy is
What can not treat solid carcinoma？Because cancerous tissue and cancer organ have larger construction machine power, chemical energy and heat in solid carcinoma
Can be molecular function, lack mechanicals efforts, can be to the less cancer cell generation effect of mechanical force, it is impossible to which solid carcinoma is produced
Direct effect.Slip extrusion friction mechanical force and the surface hyperpyrexia for producing that therapeutic equipment high speed is rotated, pass through can medicine
The strong keratoderma of construction machine power, slowly run in therapeutic equipment rub static friction mechanical force and the endogenous heat for producing, and make
Firmly up to internal organ deep tissues and bone surface, recover function and promote drug absorption.Mechanical presses are rubbed by the present invention, thing
The superior therapeutic technology that heat, chemicals are combined as a whole is sent in reason heat production, can be to prostate cancer, leukaemia, lymph cancer, mammary gland
The metastasis of cancer such as cancer and lung, liver, stomach, esophagus, intestines, courage, pancreas and solid carcinoma carry out curative therapy, rather than auxiliary treatment and appease
Treatment.
For abundant open innovation and creation, the present invention enters to cutaneous penetration chemotherapeutic treatment metastasis of cancer relative theory and technology
Row is described in detail.
First, the present Research of cutaneous penetration
The outermost layer of human body skin epidermis is the tough and tensile cuticula of about 20 layers of overlap, and it is to from extraneous physics and change
Learn the fine barrier for stimulating.The liposome for being loaded with medicine is administered can many drugs through skin, but in most cases, medicine
Be trapped in the top or cuticula top of epidermis, treatment skin disease effectively, but for Formulations for systemic administration less suitable.Transdermal is given
Medicine system is limited to the skin preparation for external use of local different from effect, and the target of Percutaneously administrable preparation is in whole body and tissue deep.
According to the research of Univ Munich Germany, when such as making carrier with liposome, in the water that skin layers difference hydration levels are produced
Under osmotic pressure, carrier is deformable and passes through the skin passage that aperture is its own size 1/5th or even 1/10th
And itself complete body is unaffected.Its mechanism will be deformed upon when ambient pressure and space constraints are subject to when carrier,
Easily through less than its diameter several times of passage.In terms of pharmacy promotees to ooze Effect study, NP, LS or emulsion is also can use as medicine
Thing carrier promotes the absorption of medicine.
Fluorouracil is one of key agents currently used for treatment tumor in digestive tract, but absorption difference, toxicity are larger, and is
A kind of polarity and low fat soluble drug, although molecular weight is low, is still difficult to pass through keratoderma.But fluorouracil emulsion is to suppression
Cancer cell processed is particularly useful through vasculolymphatic transfer or local treatment lymphsystem tumor.Can see in sum, extruding force
Intensity is the crux factor of Drug Percutaneous Absorption, when high intensity extruding force, hyperpyrexia and skin absorption promoter are combined by the present invention
When carrying out cutaneous penetration together, obvious action can be produced.It is lasting, constant and controllable that transdermal drug delivery system (TTS) can be produced
Blood concentration, mitigate toxic and side effect, it is to avoid liver stomach first pass effect, improve bioavilability；Mitigate the pain of injecting drug use；With
Medicine and drug withdrawal are convenient；Reduce administration number of times and dosage.If being not intended to percutaneous drug absorption produces whole body therapeutic effect, can be in system
In agent add vasoconstrictor, such as in adriamycin (ADR) ointment addition vasoconstrictor nitric acid bitter edible plant oxazoline (NPZ), can make Ah
Mycin keeps higher concentration in local skin.So, existing medicine is made full use of by the research of formulation and transdermal drug delivery system,
It is possible to find more excellent solution, so as to the cure rate for improving metastasis of cancer or the life cycle for extending patient, improves life
Bioplasm amount.
2nd, the principle that with cutaneous penetration chemotherapy combine is massaged
Clinical data shows even if cancer patient carries out normalized treatment after surgery, but still have most of patient answer
Send out, and perform the operation at present chemicotherapy treating cancer when, do not carry out overall treatment to the interior environment of patient, so cancer metastasis
Recurrence is inevitable, it is necessary to while for local patholoic change site treatment, changes the interior environment of patient, really could control
More cancer.Modern system science explanation：The overall feature of things from the knowledge of part can not be deduced out, system be key element and
The integration of its relation.The effect of structure treatment can only be illustrated by the globality combined with functional treatment, if knot
Conjunction mode changes, and these effects will constitute other things.
Medicinal massage, ancient claim cream to rub, just extensively started to rub technology treatment using cream early in 2000 Nian Qian China Han dynastys
Disease, is the main method that controls outside Chinese Traditional Medicine, is by the two kinds of different treatments of massotherapy and Herbal medicines for external use Transdermal absorption
It is combined as a whole, effect is used individually effect better than massage and Herbal medicines for external use.According to cream rub principle development the present invention, in transdermal
Massage is carried out while administration chemotherapy and has recovered functional treatment, symmetrical combination can produce high-level globality effect, concrete detailed
Describe in detail bright referring to this series of products of prior art《Cream rubs device》In ZL2016202539444《Cream rubs technical indicator schematic diagram》,
Description of the invention accompanying drawing 6.Physical enhancement instrument of the prior art, such as ion-conductance dialysis, electroporation, ultrasound-transdermal administration
Deng simply a kind of physical enhancement instrument, itself does not have therapeutic potential, will not produce globality remarkable result.
3rd, cancer therapy drug used in cutaneous penetration chemotherapy
With regard to the outer property for controlling medicine of application：Master Wu Shiji is controlled outside the Qing Dynasty is famous to exist《Li Yue Pianwen, Rhymed Discourse for Topical Remedies》In think " to control outward
Medicine that is, the interior medicine that controls ",《Percutaneous dosing novel form》The author Zheng Junmin of page 69 think that " (transdermal drug) is contemplated that from suitable
When the liquid of concentration, especially hypertoxic medicine and valuable drug, clinic typical concentrations are 1%-10% or so at present ".Japanese force field
" life science delivery system " that pharmaceutical industries are write, (compiles referring to Japanese economy plan Room aggregate plan office《Promote
The technological prediction 101 of economic 2010》), think in book：" delivery system is the treatment method of a new generation, is acquirement
Key technology necessary to breaking through has the research ... ... to medicine through skin, mucosa absorption mechanism to make because of secondary using the past
With the compound that can not be developed." of the invention wide using medicament kind is controlled outward, following outer transdermal drug of controlling now is provided for joining
Examine.
1st, basis《Newly organized tumour medicine handbook》Fu Guiying chief editors Golden Shield publishing house April in 2016 the 1st edition.
Page 35, the fluorouracils of page 36：It is mainly used in treating tumor in digestive tract, is also commonly used for treating breast cancer, oophoroma, lung
Cancer, cervical carcinoma, carcinoma of urinary bladder and cutaneum carcinoma etc. or larger dose treatment chorioepithelioma.Outside fluorouracil 5%-10% ointment
With 2 times a day.
The awei huapi plaster, awei huapi gaos of page 421：Indication, changes ruffian and disappears product.For qi stagnation hemagglutination, abdominal mass lump in the abdomen, epigastric pain, chest side of body
Turgor.It is applied to all internal organs and the gynecological tumor lump in the abdomens such as liver, courage, stomach, lung, oesophagus, intestines, bladder, kidney.We contain Radix Aconiti, life
The toxic medicaments such as radix aconiti agrestis, realgar, camphor, skin ulceration and allergic person should not apply.External application heating soften, be affixed on navel or
Affected part.Classification：Pharmacopeia kind, prescription medicine.Attached：Ointment can be diluted by this Application of device.
2、《Newly organized external used medicine handbook》Yu Xiulu etc. is edited, Shandong science tech publishing house, September the 1st edition 218 in 1996
Page page -225, the antineoplastic classification that can be for external application：
Alkylating agent：Mustine hydrochlcride, mustard gas, thiophene are for croak, carmustine, mitrocaphane (AT-1258), glyciphosphoramide etc..
Antimetabolite：Fluorouracil, hydroxycarbamide, ancitabine, cytarabine etc..
Antitumor antibiotics：Bleomycin.
Anticancer plants and Chinese herbal medicine：Camptothecine, cantharidin, oil of zedoary turmeric, monocrotalinum, colchicine etc..
Hormone：Estradiol Valerate
Miscellany：Sitosterol, poly IC, interferon, transfer factor
3、《Cream dressing treatment method》Zhang Qiwen chief editors, China Medical Science Press, April in 2013 the 1st edition
Page 358, anti-cancer paste.This plaster reduces can kinds of tumors, can extend the life of cancer patient.Adapt to illness：Lung
Cancer, nasopharyngeal carcinoma, the cancer of the esophagus, cancer of the stomach, intestinal cancer, liver cancer, breast cancer, carcinoma of urinary bladder, leukaemia.
4、《Pharmacy development and prospect》Wu Lei, put down its can edit, Chemical Industry Press, July in 2002 the 1st edition.
Page 94, page 95：TTS (transdermal drug delivery system) researchs of China are concentrated mainly on liposome, electro-ionic osmosis, transdermal and promote
Enter agent screening and percutaneous mechanism research.Have developed oleic acid, compound thalidasine, compound fluorouracil, camptothecine, first ammonia butterfly
The multiphasic liposomeses such as purine, endoxan, polysaccharide and cis-platinum.China has amphotericin B, Doxorubicin, taxol etc. at present
Medicinal liposome is approved to enter clinical research.Page 9, page 13, page 14, the target of percutaneous drug administration preparation is deep in whole body or tissue
, then may more there be a therapeutic potential in portion than systemic blood levels in lesions position release medicine, concentrate kill cancer cell and less or
Not damage healthy cells, to improving the effect of chemotherapeutics and extending, improve the life of tumour patient, with very positive meaning
Justice.Page 38, page 131, page 141, for transdermal drug delivery system, find new transdermal penetration enhancer, percutaneous technique and new transdermal and give
Drug carrier is the important topic of research.China has been developed for the sustained-release preparation and preparation capable of permeating skin of many, and the overwhelming majority is imitative
Product kind.Needs are orienting the reinforcement of the aspects such as the new technology of conveying, controlled release and TTS (transdermal drug delivery system), new method, new way
Innovation.
4th, summarize
The concept of diseases is the summary recognized by Disease Essence, so as to determine the control principle and technical measures of disease.Anticancer
Transfer is the key problem for the treatment of of cancer, and the so high death rate occurs in metastasis of cancer patient, shows should to take metastasis of cancer
Control principle and technical measures are summarized, and change current condition.The current primary treatments of common solid tumour are operations
Cut off, perform the operation the tumor effect not spread by early stage preferably, perform the operation bad to existing metastatic tumour therapeutic effect with radiotherapy.When
Most patients have carried out Post operation in hospital, receive chemotherapy, are Venous Chemotherapy.Judge chemotherapeutic anti-cancer drug effect at present
The index of fruit includes at following 4 points：1. cancer is cured.2. prolong life.3. anesis.4. tumor regression.As anticarcinogen is without ruling by law
Solid carcinoma is treated, so brainstrust is typically not by " cancer healing " as index.
1st, cure the problem that cancer is a treatment technology amount of force, depend merely on anticarcinogen and cannot treat solid carcinoma, because
It is a kind of primary motor form for chemical property anticarcinogen, it is impossible to which direct effect is produced to solid carcinoma advanced motion form pathology,
Anticarcinogen is restricted by symmetrical mechanical-physical pathology, the big effect of curative effect low side effect occurs.Prior art (《Kinds of tumor
Non-operative treatment》Bu Ziying writes page 25, Science Press) think：To tumour and its surrounding tissue manual massage, tumor entity is made
Excessively it is squeezed and can promotes the transfer of tumour.But the effect that massage independent role effect is produced in entirety with it is not
The same, when massage is with chemotherapy collective effect, the cancer cell of the transfer that comes off can be killed, and mechanical-physical function reduction obtains extensive
Multiple, wholistic therapy solid carcinoma can produce remarkable result.Human life motion by physics, chemical interdependence constitute senior
Forms of motion, in life movement, physics law and chemical rule obey the global regularity of life advanced motion form, senior fortune
Dynamic form of therapy technology be with cure as target, different from primary motor formal technique symptomatic treatment.So, overall property is not
Can be changed from the change of part, depend merely on anticarcinogen and cannot treat solid carcinoma, but the wholistic therapy of advanced motion form, can
Using by " healing cancer " as index.Can refer to Figure of description 5.
2nd, prolong the problem that life is whether an orientation treatment meets the natural law, such as《Lung cancer metastasis》(people's health is published
Society's in June, 2011 page 284) [U.S.] University of Michigan Venkeshwarke Shamooni, described in author：" operation chemicotherapy and each
Plant and kill cancer cell treatment technology, can bring about tangible results to eliminating, controlling cancer metastasis focus, but not know office so far
Why not portion can improve the existence of patient after controlling most of micrometastasis stoves, because great majority receive the metastasis of cancer of local treatment
Patient ultimately succumbs to systemic disease progress, rather than local failure ".Above-mentioned systemic disease progress is whole body function pathology, is dead
Die principal element.Modern medicine is considered " structures shape function ", only carries out structure for main treatment, does not carry out function for main treatment
It is the main cause for causing death.And two kinds of different versions of " structures shape function " and " function decision structure ",
Different phase alternating during pathological development is leading leading, plays different effects.Wherein " structures shape function ", it is to determine
The partial function of same level, rather than high-level allomeric function；" function decision structure " is that allomeric function determines low level
Part-structure.Prior art focuses on the research to structure division, lacks the global configuration to structure division with funtion part and studies.
In the natural law, from the new quantitative change of quantitative change qualitative change, so mutually convert, alternate, constitute things eternal
Evolution.So, the mass action as long as killing cancer cell and recovery pathology function are mutually promoted, it then follows correct treatment side
To patient would not be dead.The present invention is also a kind of massager in itself, using the traditional Chinese medical science recover function correction liquid carry out medicine by
Rub, remarkable result can be produced to recovering body local and whole body function, concrete with regard to how extend patient vitals in detail, can be with
Invent with reference to this series《Hepatoma Metastasis therapeutic equipment》Specific considerations data in ZL201410524366 9, Figure of description 7 are also entered
Introduction is gone.
3rd, tumor regression is a problem during pathological development, it is impossible to represent the development trend of pathology, only when swollen
Knurl is reduced when being combined as a whole with functional rehabilitation, just has essential meaning.Because function pathology is the basis that cancer cell is produced, only kill
The cancer cell that goes out does not recover functional treatment, and tumour there is also and increase again repeatedly, should treat both principal and secondary aspect of disease.Rubbing in therapeutic equipment is quiet
Friction is profound to recover functional treatment, can be thin with the intra-tumor injection in local chemotherapy, chemotherapy, chamber chemotherapy killing cancer
Born of the same parents combine.The research that metastasis of cancer is recurred is thought according to prior art：Although various cancers respectively have " individual character ", " general character "
It is main, the present invention is mainly studied to " general character " of cancer.
" science is false to learn the exploration for belonging to creative, and generally, the level of scientific hypothesis is had with the level of scientific achievement
Certain corresponding relation.
The scientific hypothesis of mean level+general scientific research apparatus, equipment=low-level scientific achievement.
The scientific research apparatus of the scientific hypothesis+high, precision and frontier of mean level, the scientific achievement of equipment=medium level.
High-caliber scientific hypothesis+general scientific research apparatus, equipment=high-caliber scientific achievement ".
Referring to《Medical science and technology philosophy introduction》He Daren write, Higher Education Publishing House, 2005 page 104.
In sum, all achievements acquired by medical development, can only all be that the mankind recognize long korneforos with regard to human life
In one stage, need continuous innovation and development.Control outside application for the treatment of device model machine bound drug at present common in treatment belly
Significant effect is achieved in terms of disease, it is desirable to is made progress in terms for the treatment of metastasis of cancer, is released pain for patient as early as possible.
Description of the drawings：
Fig. 1 is metastasis of cancer transdermal medicine for treating device front view of the present invention
Fig. 2 is the direction view of therapeutic equipment A shown in Fig. 1.
Fig. 3 is the direction view of therapeutic equipment B shown in Fig. 1.
Fig. 4 is the view of therapeutic equipment safety pad shown in Fig. 1.
Fig. 5 is《Advanced motion form of therapy technology schematic diagram》.
Fig. 6 is《Cream rubs technical indicator schematic diagram》.
Fig. 7 is《Metastasis of cancer generation and evolution schematic diagram》
Specific embodiment
In metastasis of cancer transdermal medicine for treating device shown in Fig. 1 of the present invention：1 is casing, and 2 is motor, and 3 is small friction head, 4
It is safety pad, 5 is coarse friction cloth, and 6 is fixed cover, and 7 is forward and reverse speed-regulating switch.Fig. 2 is the direction view of therapeutic equipment A shown in Fig. 1.
Fig. 3 is the direction view of therapeutic equipment B shown in Fig. 1.Fig. 4 is the view of therapeutic equipment safety pad shown in Fig. 1.Fig. 5 is《Advanced motion form of therapy
Technology schematic diagram》.Fig. 6 is《Cream rubs technical indicator schematic diagram》.Fig. 7 is《Metastasis of cancer generation and evolution schematic diagram》.
A kind of metastasis of cancer transdermal medicine for treating device, it are by casing, motor, small friction head, safety pad, coarse friction
Cloth, fixed cover, forward and reverse speed-regulating switch, fluorouracil topical agent composition, former carninomatosis stove portion and around, metastatic lesion portion and
Surrounding, Lymph Node Metastasis position and hematogenous metastasis position, the therapeutic equipment of hand-held high-speed rotation carry out killing cancer cell with cutaneous penetration
Based on, the wholistic therapy that recovers supplemented by function, after treatment end the hand-held therapeutic equipment for slowly running carry out to recover based on function,
Cutaneous penetration kills the wholistic therapy supplemented by cancer cell；It is characterized in that：Fixed installation motor, 16 small friction heads in casing
Into square arrangement in the casing, orientation and casing to handle direction parallel, after safety pad is inserted in small friction head
It is connected and fixed with casing inner plane projection screw with bolt, motor drives small friction head 10000 turns of high-speed rotations per minute, little
Type friction head is justified center and fixes a cylinder to round edge circle radius length, and cylinder head plane has a chisel edge raised, and chisel edge is raised long
Degree is small friction head radius, and contacting with coarse friction cloth carries out scraping extrusion friction；Based on cutaneous penetration killing cancer cell
In the stage, first with around, metastatic lesion portion and surrounding, Lymph Node Metastasis position and hematogenous metastasis position coat fluorine and urinate in carninomatosis stove portion
Pyrimidine topical agent, the therapeutic equipment of hand-held high-speed rotation extruding sliding friction carry out cutaneous penetration and kill based on cancer cell, recover
Wholistic therapy supplemented by function, then adjusts rotation direction and rotating speed, and the hand-held therapeutic equipment for rubbing static friction that slowly runs is upper
State position carry out promote drug absorption recover function based on, the wholistic therapy supplemented by cutaneous penetration.
Claims (1)
1. a kind of metastasis of cancer transdermal medicine for treating device, it be by casing, motor, small friction head, safety pad, coarse friction cloth,
Fixed cover, forward and reverse speed-regulating switch, fluorouracil topical agent composition, former carninomatosis stove portion and around, metastatic lesion portion and week
Enclose, Lymph Node Metastasis position and hematogenous metastasis position, the therapeutic equipment of hand-held high-speed rotation carries out killing cancer cell with cutaneous penetration and is
Wholistic therapy that is main, recovering supplemented by function, after treatment end, the hand-held therapeutic equipment for slowly running carries out recovering based on function, thoroughly
The wholistic therapy supplemented by cancer cell is killed in skin administration；It is characterized in that：Fixed installation motor in casing, 16 small friction heads into
In the casing, orientation and casing handle that direction is parallel to square arrangement, and safety pad is used after being inserted in small friction head
Bolt is connected and fixed with casing inner plane projection screw, and motor drives small friction head 10000 turns of high-speed rotations per minute, small-sized
Friction head is justified center and fixes a cylinder to round edge circle radius length, and cylinder head plane has a chisel edge raised, chisel edge projection length
It is small friction head radius, contacting with coarse friction cloth carries out scraping extrusion friction；Cutaneous penetration kill cancer cell based on rank
Section, first in carninomatosis stove portion with around, metastatic lesion portion and surrounding, Lymph Node Metastasis position and hematogenous metastasis position, coat fluorine urinate phonetic
Pyridine topical agent, the therapeutic equipment of hand-held high-speed rotation extruding sliding friction carry out cutaneous penetration and kill based on cancer cell, recover work(
Wholistic therapy supplemented by energy, then adjusts rotation direction and rotating speed, and the hand-held therapeutic equipment for rubbing static friction that slowly runs is above-mentioned
Position carry out promote drug absorption recover function based on, the wholistic therapy supplemented by cutaneous penetration.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611119507.4A CN106492343A (en) | 2016-12-08 | 2016-12-08 | Metastasis of cancer transdermal medicine for treating device |
| PCT/CN2017/103831 WO2018103433A1 (en) | 2016-12-08 | 2017-09-28 | Cancer metastasis transdermal drug delivery therapeutic device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611119507.4A CN106492343A (en) | 2016-12-08 | 2016-12-08 | Metastasis of cancer transdermal medicine for treating device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018103433A1 (en) * | 2016-12-08 | 2018-06-14 | 李复生 | Cancer metastasis transdermal drug delivery therapeutic device |
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