CN106491798A - A kind of chilblain Chinese medicine note and preparation method thereof - Google Patents
A kind of chilblain Chinese medicine note and preparation method thereof Download PDFInfo
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- CN106491798A CN106491798A CN201610980037.4A CN201610980037A CN106491798A CN 106491798 A CN106491798 A CN 106491798A CN 201610980037 A CN201610980037 A CN 201610980037A CN 106491798 A CN106491798 A CN 106491798A
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- A61K35/63—Arthropods
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- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention discloses a kind of chilblain Chinese medicine note and preparation method thereof, and including carrier and the ointment being arranged on carrier, carrier includes the internal layer of bonding, outer layer, arranges and remove wet layer between internal layer and outer layer, and ointment includes the raw material of following weight portion：35 parts of Camphora, 20 40 parts of Folium Artemisiae Argyi, 10 30 parts of Pericarpium Zanthoxyli, 5 15 parts of Exocarpium Benincasae, 5 15 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 20 30 parts of Mel, 40 60 parts of egg yolk, 10 20 parts of Radix Angelicae Sinensis, 10 20 parts of Oleum Terebinthinae.The each raw material dosage of the present invention is appropriate, and compatibility rationally, relieves the pain symptom of itching of chilblain, and there is soothing effect；Raw material type is few, and, up to 97%, up to 93%, therapeutic effect is notable for cure rate for treatment chilblain total effective rate.
Description
Technical field
The invention belongs to treating skin disease Prevention Technique field, more particularly to a kind of chilblain Chinese medicine note and preparation method thereof.
Background technology
Chilblain is that occur in tip position localized erythema diseases associated with inflammation after body is subject to cold invasion and attack, and common infringement is
The edematous erythema of limitation congestive mulberry protuberance, indefinite border, severe patient can occur vesicle, formed after rupture rotten to the corn or
Ulcer, has pigmentation or atrophic scar more afterwards, aggravates after itching and being heated, and symptom often occurs leaking cruelly aerial soft group
Knit, for example ear-lobe, particularly contact the soft tissue of the joint of ice-cold external substance, such as right finger joint.Chilblain is
The clinically commonly encountered diseases in winter, frequently-occurring disease, prurituss pain bring pain to patient, on the market the medicine of existing treatment chilblain
Though there is certain curative effect, work relatively slow, therapeutic effect is poor, and to the easy generation allergy of skin.
Application number CN201410124946.9 discloses a kind of plaster for preventing and treating chilblain, including upper strata stretch fabric
With lower floor's stretch fabric, two stretch fabric sizes and shape identical, both corresponding edges suture up and down and to form one and put medicine chamber；Upper strata
The centre of stretch fabric is provided with slide fastener, and the medicine chamber of putting is divided into multiple semiclosed put by many sewing threads perpendicular to slide fastener
Prescription unit, semiclosed the putting are placed with the two ends of medicated bag, upper strata stretch fabric and lower floor's stretch fabric in prescription unit and are provided with phase interworking
The alphabetical thread gluing of conjunction.The invention is disadvantageous in that：It is banded at chilblain symptom using stretch fabric, but the position of chilblain is simultaneously
It is not suitable for tying up, such as ear-lobe, and diverse location needs different size of plaster of arranging in pairs or groups, so the plaster makes not side
Just.
Application number CN201410475741.5 discloses one kind and treats chilblain external application medical ointment, including following weight content into
Point：Flos Carthami 10-20 parts, Ramulus Cinnamomi 15-20 parts, Herba Schizonepetae 10-20 parts, Pericarpium Zanthoxyli 20-30 parts, Fructus Capsici 1-5 parts, Rhizoma Alpiniae Officinarum 5-10 parts, Radix Curcumae
2-3 parts, vaseline 20-40 parts.The invention is disadvantageous in that：For the chilblain symptom festered is had occurred and that, will be containing peppery
The ointment of green pepper is applied on wound, there is sense of discomfort.
Content of the invention
In view of this, the purpose of the present invention is for the deficiencies in the prior art, there is provided a kind of chilblain Chinese medicine patch and its preparation
Method, each raw material dosage of the invention are appropriate, and compatibility rationally, relieves the pain symptom of itching of chilblain, and there is soothing effect；Raw material
Species is few, and, up to 97%, up to 93%, therapeutic effect is notable for cure rate for treatment chilblain total effective rate.
For reaching above-mentioned purpose, the present invention is employed the following technical solutions：
Chilblain Chinese medicine note, including carrier and the ointment being arranged on carrier, the carrier includes the internal layer of bonding, outer layer, described
Arrange between internal layer and outer layer and remove wet layer, the ointment includes the raw material of following weight portion：Camphora 3-5 parts, Folium Artemisiae Argyi 20-40 parts,
Pericarpium Zanthoxyli 10-30 parts, Exocarpium Benincasae 5-15 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 5-15 parts, Mel 20-30 parts, egg yolk 40-60 parts, Radix Angelicae Sinensis 10-20 parts, Lignum Pini Nodi
Oily 10-20 parts.
Further, the internal layer is non-woven fabrics, described except wet layer be calcium chloride or calcium sulfate, the outer layer is waterproof material
Material.
Further, the ointment includes the raw material of following weight portion：Camphora be 4 parts, 30 parts of Folium Artemisiae Argyi, 20 parts of Pericarpium Zanthoxyli, the winter
10 parts of melon skin, 10 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 25 parts of Mel, 50 parts of egg yolk, 15 parts of Radix Angelicae Sinensis, 15 parts of Oleum Terebinthinae.
Further, leaf of the Folium Artemisiae Argyi for Qi Ai.
A kind of preparation method of chilblain Chinese medicine note, comprises the following steps：
（1）By Camphora, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Angelicae Sinensis go the removal of impurity, after cleaning-drying standby, take the chicken after cleaning
The egg yolk of egg is standby；
（2）Camphora, Radix Angelicae Sinensis, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi) is weighed, the water of 15-20 times of medical material gross weight is added, 30- is soaked
After 60min, 2-4 hours are decocted, filter, obtain filtrate and filtering residue, standby；
（3）By step（2）In obtain filtrate slow fire heating, and in filtrate add Mel, be concentrated to give relative to the close of water
The thick paste for 1.36-1.40 is spent, standby；By step（2）In the filtering residue that obtains dry, be then ground to powder, in 60-65 DEG C of bar
Dry under part, reuse small fire and fry to brown color, obtain medicated powder, standby；
（4）By step（3）The thick paste that obtains, medicated powder mixing, and be added thereto to egg yolk and Oleum Terebinthinae, stirring 20-40min is to mixed
Close uniformly, obtain ointment, standby；
（5）Coating step first on the internal layer of carrier（3）In medicated powder, then coating step on medicated powder（3）In obtained thick
Cream, finally coating step on thick paste（4）The ointment for obtaining, obtains semi-finished product；Semi-finished product are stood, Chinese medicine patch is obtained final product.
Further, step（1）Middle egg is cleaned after sterilized, after broken shell using disposable syringe extract egg yolk
Standby.
Further, step（3）Described in dry 6-12h under the conditions of drying temperature 50-60 DEG C.
Further, step（3）Described in medicated powder particle diameter be 250-300 mesh.
Further, step（5）Described in stand be to be 50%-60%, stand 3- under the conditions of temperature 20-25 DEG C in humidity
5min.
The present invention ointment pharmacological action be：
Camphora：Property heat, acrid in the mouth, GUIXIN, spleen channel；For oral administration：Having one's ideas straightened out, it is dirty to ward off, external：Dehumidifying parasite killing, temperature is scattered, antipruritic, analgesia.This product
Hot dry strong, poisonous, external can dehumidify, and energy detoxicating and killing parasites, receive detumescence, antipruritic effect.This product is hot must to be dissipated, qi stagnation removing,
Reducing swelling and alleviating pain；Camphora is applied to skin and has clinically has analgesia, itching-relieving action with camphorated oil.
Folium Artemisiae Argyi：Bitter in the mouth, warm in nature, enter spleen, liver and kidney channel；Have recuperating depleted YANG, rationale blood, by raw, arresting bleeding and miscarriage prevention the effects such as；Tool
There is the antiabortive effect for only collapsing dispelling cold and removing dampness of regulating menstruation, hemostasis, and Folium Artemisiae Argyi has antibacterial and antivirus action.
Pericarpium Zanthoxyli：Acrid in the mouth, warm in nature, returns spleen, stomach, kidney channel；Have warming middle-JIAO to promote flow of QI, dispelling cold and removing dampness, stagnation resolving, the dyspepsia that disappears, logical three
Jiao, warming the spleen stomach, the right kidney gate of vitality is mended, ascarid, stopping leak is killed and is rushed down effect.
Exocarpium Benincasae：Sweet in the mouth, cold nature enter spleen, intestinal, warp；Have to dry and chase after the effect of wind, spleen reinforcing pathogenic fire purging.
Cortex cinnamomi japonici (Ramulus Cinnamomi)：Acrid in the mouth, warm in nature, enter the heart, liver,spleen,kidney four are passed through；There is warming the spleen stomach, warm Liver and kidney, cold-dispelling pain-relieving, dissipating blood stasis for subsidence of swelling
The effect of.For coldness and pain in the epigastrium, vomiting is had loose bowels, cold waist and knee acid, cold hernia stomachache, arthralgia due to cold-dampnes, the stagnant dysmenorrhea of the stasis of blood, dysentery, hemorrhoidal hamorrhage, fall
Beat and swell and ache.
Mel：Sweet in the mouth, mild-natured, return lung, spleen, large intestine channel；There is invigorating middle warmer, moisturize, pain relieving, detoxify；For the empty pain of gastral cavity abdomen, lung
Dry dry cough, dry constipation of intestines；External treatment skin infection is not held back, burn due to hot liquid or fire.
Egg yolk：It is rich in the trace element such as fatsoluble vitamin, monounsaturated fatty acid, phosphorus, ferrum, the work with Glycerin
With skin exquisiteness can be made glossy, dry skin and winter or the area for especially drying is especially suitable for.
Radix Angelicae Sinensis：Sweet in the mouth, warm in nature, Return liver, the heart, spleen channel；Have enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation the effect of.Can
For all cards of main blood deficiency, menoxenia, amenorrhea, dysmenorrhea, poly- lump in the abdomen knot, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine just
Weight, ulcer sores, injury from falling down after difficult, bloody dysentery.
Oleum Terebinthinae：Have and promote local blood circulation, alleviate swelling and slight analgesic effect；For mitigating myalgia, pass
Arthralgia, neuralgia and sprain.
The invention has the beneficial effects as follows：
1. the carrier of the present invention includes internal layer, outer layer and is located between internal layer and outer layer arranging except wet layer, and internal layer can be used
The non-woven fabrics of breathability, internal layer both sides are equipped with binding agent, binding agent using of the prior art, except wet layer can be used
Calcium chloride, calcium sulfate, outer layer can use waterproof material；In use, the position according to chilblain cuts relative the present invention
The internal layer and outer layer of size is answered, is placed between inner side and outer layer except wet layer, then by internal layer and outer layer by viscous on internal layer
Knot agent carries out bonding, and ointment is applied to after finishing bonding the another side of internal layer, and the binding agent by internal layer edge is sticked
In chilblain symptom position, the position that this structure design can be directed to chilblain is quick, rational the selection of material, and processing technology letter
Single.
2. Chinese medicine preparation treatment chilblain of the present invention, according to its cause of disease and clinical onset feature, its plaster is stopped with damp eliminating, detumescence
Itch and carry out prescription medicine for Therapeutic Method, with Camphora, Folium Artemisiae Argyi, three kinds of Chinese medicines of Pericarpium Zanthoxyli as monarch drug, Camphora be applied to skin have dehumidifying,
Antipruritic, analgesic efficacy, Folium Artemisiae Argyi and Pericarpium Zanthoxyli have rationale blood, by raw effect；In addition, Chinese medicine preparation of the present invention uses Fructus Benincasae
Skin, Cortex cinnamomi japonici (Ramulus Cinnamomi) auxiliary, the phenomenon for further improve patients symptomatic's skin turgor, being chapped from the cold, all medicines share is ministerial drug altogether；Additionally, Radix Angelicae Sinensis
There is thin blood, promoting blood circulation, the drug effect for effectively improving monarch drug and the effective drug duration for strengthening monarch drug, and Radix Angelicae Sinensis herb to have
Fragrant the characteristics of, is effectively nursed one's health to the penetrating odor of Camphora, is prevented from causing abnormal smells from the patient sense of discomfort in coating procedure, is adjuvant drug；
Oleum Terebinthinae is used as making medicine promote the blood circulation at symptom, and there is Oleum Terebinthinae volatility to be conducive to drug storage go directly focus, spy
Why it is not the chilblain to joint, Oleum Terebinthinae also helps the effect for improving rheumatic arthritis, antibacterial.The present invention uses honeybee
Honey, egg yolk are adjuvant, and Mel and egg yolk contain aminoacid, enzyme, hormone, vitamin and the sugar that can be absorbed by the body in a large number, has
Gentle skin and effect of nourishes rough skin, after preventing relieving itching and eliminating swelling, there is the phenomenon of fold, peeling in superficial skin, effectively improves this
The soothing effect of invention.
To sum up, the ointment for the treatment of chilblain disclosed by the invention, mutually supports between plurality of raw materials, mutually cooperates with, make drug effect
At through disease and realize internal and external application, shorten treatment cycle, improve therapeutic effect.
3. preparation method of plaster of the present invention is simple, using being cooked by slow fire each taste raw material of Chinese medicine so that having in raw material of Chinese medicine
Effect composition is at utmost leached, and obtains thick paste；Then using middle oven drying at low temperature, stir-fry medicinal residues, grinds to form medicated powder, finally will
Thick paste and medicated powder are used in mixed way, the comprehensive effective ingredient for remaining raw material of Chinese medicine of the Chinese medicine patch of preparation so that Chinese medicine patch has
Effect composition farthest can be absorbed by the patient.
In addition, this method is formed using traditional decoction and grinding compounding, obtained ointment Small side effects, to human body skin
Or wound does not have zest, short treating period, cure rate are high, and low cost, with wide market prospect.
4. the step of preparation method of the present invention（5）Middle layering sets gradually medicated powder, thick paste, ointment, is located at centre during use
The thick paste of layer can be diffused to the both sides of medicated powder and ointment, not only can improve the drug effect of the present invention, and symptom position
The perspiration discharged of capillary blood pore can also enter in carrier, and by absorbing to perspiration except wet layer with diffusion process, anti-
Only Chinese medicine patch sticks sense of discomfort present in process, with respect to the position that perspiration remains in chilblain symptom, effectively prevents a crease in the skin
Problem, improve ointment soothing effect.
In addition, the outer layer of carrier adopts the plastic film such as waterproof material, such as PA, PES, not only prevent outside moisture from entering and remove
In wet layer, and prevent the property of medicine of ointment outwards to volatilize, and then improve drug effect.
Specific embodiment
With reference to embodiment, the invention will be further described.
Embodiment one
A kind of chilblain Chinese medicine note, including carrier and the ointment being arranged on carrier, carrier includes internal layer, outer layer, internal layer and outer layer
Between arrange remove wet layer, internal layer is non-woven fabrics, except wet layer be calcium chloride, outer layer is waterproof material；Ointment is coated in internal layer, its
In, ointment includes the raw material of following weight portion：3 parts of Camphora, 20 parts of Folium Artemisiae Argyi, 10 parts of Pericarpium Zanthoxyli, 5 parts of Exocarpium Benincasae, 5 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Mel
20 parts, 40 parts of egg yolk, 10 parts of Radix Angelicae Sinensis, 10 parts of Oleum Terebinthinae.
A kind of preparation method of chilblain Chinese medicine note, comprises the following steps：
（1）By Camphora, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Angelicae Sinensis go the removal of impurity, after cleaning-drying standby, take the chicken after cleaning
The egg yolk of egg is standby；
（2）Camphora, Radix Angelicae Sinensis, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi) are weighed by formula and is mixed, add 15 times of medical material gross weights
Water, after immersion 30min, decocts 2 hours, filters, obtain filtrate and filtering residue, standby；
（3）By step（2）In obtain filtrate slow fire heating, and in filtrate add Mel, be concentrated to give relative to the close of water
The thick paste for 1.36 is spent, standby；By step（2）In the filtering residue that obtains dry, be then ground to the powder of 250 mesh, in 60 DEG C of bars
6h is dried under part, and is fried to brown color using small fire, obtain medicated powder, standby；
（4）By step（3）The thick paste that obtains, medicated powder mixing, and egg yolk and Oleum Terebinthinae is added thereto to using syringe, stir
20min obtains ointment to mix homogeneously, standby.
（5）Coating step first on the internal layer of carrier（3）In medicated powder, then coating step on medicated powder（3）In be obtained
Thick paste, last coating step on thick paste（4）The ointment for obtaining, obtains semi-finished product；Semi-finished product are stood, standing is in humidity
For 3min being stood under the conditions of 20 DEG C of 50%, temperature, obtain final product Chinese medicine patch.
Embodiment two
A kind of chilblain Chinese medicine note, including carrier and the ointment being arranged on carrier, carrier includes internal layer, outer layer, internal layer and outer layer
Between arrange remove wet layer, internal layer is non-woven fabrics, except wet layer be calcium chloride, outer layer is waterproof material；Ointment is coated in internal layer, its
In, ointment includes the raw material of following weight portion：3.5 parts of Camphora, 25 parts of Folium Artemisiae Argyi, 15 parts of Pericarpium Zanthoxyli, 6 parts of Exocarpium Benincasae, 6 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), honeybee
22 parts of honey, 45 parts of egg yolk, 12 parts of Radix Angelicae Sinensis, 10 parts of Oleum Terebinthinae.
A kind of preparation method of chilblain Chinese medicine note, comprises the following steps：
（1）By Camphora, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Angelicae Sinensis go the removal of impurity, after cleaning-drying standby, take the chicken after cleaning
The egg yolk of egg is standby；
（2）Camphora, Radix Angelicae Sinensis, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi) are weighed by formula and is mixed, add 16 times of medical material gross weights
Water, after immersion 35min, decocts 2 hours, filters, obtain filtrate and filtering residue, standby；
（3）By step（2）In obtain filtrate slow fire heating, and in filtrate add Mel, be concentrated to give relative to the close of water
The thick paste for 1.37 is spent, standby；By step（2）In the filtering residue that obtains dry, be then ground to the powder of 260 mesh, in 60 DEG C of bars
7h is dried under part, and is fried to brown color using small fire, obtain medicated powder, standby；
（4）By step（3）The thick paste that obtains, medicated powder mixing, and egg yolk and Oleum Terebinthinae is added thereto to using syringe, stir
25min obtains ointment to mix homogeneously, standby.
（5）Coating step first on the internal layer of carrier（3）In medicated powder, then coating step on medicated powder（3）In be obtained
Thick paste, last coating step on thick paste（4）The ointment for obtaining, obtains semi-finished product；Semi-finished product are stood, standing is in humidity
For 3.5min being stood under the conditions of 21 DEG C of 52, temperature, obtain final product Chinese medicine patch.
Embodiment three
A kind of chilblain Chinese medicine note, including carrier and the ointment being arranged on carrier, carrier includes internal layer, outer layer, internal layer and outer layer
Between arrange remove wet layer, internal layer is non-woven fabrics, except wet layer be calcium chloride, outer layer is waterproof material；Ointment is coated in internal layer, its
In, ointment includes the raw material of following weight portion：4 parts of Camphora, 25 parts of the leaf of Qi Ai, 15 parts of Pericarpium Zanthoxyli, 10 parts of Exocarpium Benincasae, 8 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi),
25 parts of Mel, 50 parts of egg yolk, 14 parts of Radix Angelicae Sinensis, 13 parts of Oleum Terebinthinae.
A kind of preparation method of chilblain Chinese medicine note, comprises the following steps：
（1）By Camphora, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Angelicae Sinensis go the removal of impurity, after cleaning-drying standby, take the chicken after cleaning
The egg yolk of egg is standby；
（2）Camphora, Radix Angelicae Sinensis, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi) are weighed by formula and is mixed, add 17 times of medical material gross weights
Water, after immersion 45min, decocts 3 hours, filters, obtain filtrate and filtering residue, standby；
（3）By step（2）In obtain filtrate slow fire heating, and in filtrate add Mel, be concentrated to give relative to the close of water
The thick paste for 1.38 is spent, standby；By step（2）In the filtering residue that obtains dry, be then ground to the powder of 270 mesh, in 62 DEG C of bars
8h is dried under part, and is fried to brown color using small fire, obtain medicated powder, standby；
（4）By step（3）The thick paste that obtains, medicated powder mixing, and egg yolk and Oleum Terebinthinae is added thereto to using syringe, stir
28min obtains ointment to mix homogeneously, standby.
（5）Coating step first on the internal layer of carrier（3）In medicated powder, then coating step on medicated powder（3）In be obtained
Thick paste, last coating step on thick paste（4）The ointment for obtaining, obtains semi-finished product；Semi-finished product are stood, standing is in humidity
For 4min being stood under the conditions of 22 DEG C of 53%, temperature, obtain final product Chinese medicine patch.
Example IV
A kind of chilblain Chinese medicine note, including carrier and the ointment being arranged on carrier, carrier includes internal layer, outer layer, internal layer and outer layer
Between arrange remove wet layer, internal layer is non-woven fabrics, except wet layer be calcium chloride, outer layer is waterproof material；Ointment is coated in internal layer, its
In, ointment includes the raw material of following weight portion：4 parts of Camphora, 30 parts of Folium Artemisiae Argyi, 20 parts of Pericarpium Zanthoxyli, 10 parts of Exocarpium Benincasae, 10 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), honeybee
25 parts of honey, 50 parts of egg yolk, 15 parts of Radix Angelicae Sinensis, 15 parts of Oleum Terebinthinae.
A kind of preparation method of chilblain Chinese medicine note, comprises the following steps：
（1）By Camphora, the leaf of Qi Ai, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Angelicae Sinensis go the removal of impurity, after cleaning-drying standby, first by egg
Ozone is cleaned and is used to surface sterilization, egg yolk is extracted using disposable syringe after broken shell standby；
（2）Camphora, Radix Angelicae Sinensis, the leaf of Qi Ai, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi) are weighed by formula and is mixed, add 17.5 times of medical material gross weights
The water of amount, after immersion 50min, decocts 3 hours, filters, obtain filtrate and filtering residue, standby；
（3）By step（2）In obtain filtrate slow fire heating, and in filtrate add Mel, be concentrated to give relative to the close of water
The thick paste for 1.38 is spent, standby；By step（2）In the filtering residue that obtains dry, be then ground to the powder of 300 mesh, in 65 DEG C of bars
9h is dried under part, and is fried to brown color using small fire, obtain medicated powder, standby；
（4）By step（3）The thick paste that obtains, medicated powder mixing, and egg yolk and Oleum Terebinthinae is added thereto to using syringe, stir
30min obtains ointment to mix homogeneously, standby.
（5）Coating step first on the internal layer of carrier（3）In medicated powder, then coating step on medicated powder（3）In be obtained
Thick paste, last coating step on thick paste（4）The ointment for obtaining, obtains semi-finished product；Semi-finished product are stood, standing is in humidity
For 4min being stood under the conditions of 22.5 DEG C of 55%, temperature, obtain final product Chinese medicine patch.
In the present embodiment, preparation method step（1）Sterilizing is carried out to egg surface using ozone, is prevented on Ovum crusta Gallus domesticuss
Escherichia coli, staphylococcus aureuses, the pathogenic bacterium such as Candida albicans affect the property of medicine of Chinese medicinal ointment, increase the absorption of its property of medicine
Rate.
Embodiment five
A kind of chilblain Chinese medicine note, including carrier and the ointment that is arranged on carrier, carrier includes packing ring, internal layer, outer layer, internal layer and
Arrange between outer layer and remove wet layer, packing ring is bonded in another lateral edges of internal layer, and the opposite side of packing ring is provided with binding agent, and internal layer is nothing
Cloth is spun, except wet layer is calcium chloride, outer layer is waterproof material；Ointment is coated in internal layer, and wherein, ointment includes the original of following weight portion
Material：4 parts of Camphora, 30 parts of the leaf of Qi Ai, 20 parts of Pericarpium Zanthoxyli, 10 parts of Exocarpium Benincasae, 10 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 5 parts of Aloe, 25 parts of Mel, egg yolk 50
Part, 15 parts of Radix Angelicae Sinensis, 15 parts of Oleum Terebinthinae.
A kind of preparation method of chilblain Chinese medicine note, comprises the following steps：
（1）By Camphora, the leaf of Qi Ai, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Angelicae Sinensis go the removal of impurity, after cleaning-drying standby, first by egg
Ozone is cleaned and is used to surface sterilization, egg yolk is extracted using disposable syringe after broken shell standby；
（2）Camphora, Radix Angelicae Sinensis, the leaf of Qi Ai, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi) are weighed by formula and is mixed, add 17.5 times of medical material gross weights
The water of amount, after immersion 50min, decocts 3 hours, filters, obtain filtrate and filtering residue, standby；
（3）By step（2）In obtain filtrate slow fire heating, and in filtrate add Mel, be concentrated to give relative to the close of water
The thick paste for 1.38 is spent, standby；By step（2）In the filtering residue that obtains dry, then crush and grind to form the powder of 300 mesh,
10h under the conditions of 65 DEG C, and fried to brown color using small fire, medicated powder is obtained, standby；
（4）By step（3）The thick paste that obtains, medicated powder mixing, and egg yolk and Oleum Terebinthinae, Zhi Houjia is added thereto to using syringe
Enter Aloe and 30min is stirred to mix homogeneously, obtain ointment, standby.
（5）Coating step first on the internal layer of carrier（3）In medicated powder, then coating step on medicated powder（3）In be obtained
Thick paste, last coating step on thick paste（4）The ointment for obtaining, obtains semi-finished product；Semi-finished product are stood, standing is in humidity
For 4min being stood under the conditions of 22.5 DEG C of 55%, temperature, obtain final product Chinese medicine patch.
In the present embodiment, packing ring is bonded in another lateral edges of internal layer, and the opposite side of packing ring is provided with binding agent, can during use
Chinese medicine patch is bonded at around chilblain skin by packing ring, present invention is especially suited for the position for attaching is difficult, such as ear-lobe, handss
Abdominal part, effectively prevention stick the problem generation that process Chinese medicinal ointment comes off from carrier；
In addition, preparation method step（3）First by drying after filtering residue crushed being ground, be conducive to the effect for improving grinding
Rate, and increase Aloe in adjuvant, there is special gel using Aloe, make obtained ointment shape more preferably, Er Qielu
Luxuriant growth further can be nourished to the skin at symptom, improve the soothing effect of the present invention.
Embodiment six
A kind of chilblain Chinese medicine note, including carrier and the ointment being arranged on carrier, carrier includes internal layer, outer layer, internal layer and outer layer
Between arrange remove wet layer, internal layer is non-woven fabrics, except wet layer be calcium sulfate, outer layer is waterproof material；Ointment is coated in internal layer, its
In, ointment includes the raw material of following weight portion：4 parts of Camphora, 35 parts of Folium Artemisiae Argyi, 25 parts of Pericarpium Zanthoxyli, 12 parts of Exocarpium Benincasae, 12 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), honeybee
25 parts of honey, 50 parts of egg yolk, 16 parts of Radix Angelicae Sinensis, 15 parts of Oleum Terebinthinae.
A kind of preparation method of chilblain Chinese medicine note, comprises the following steps：
（1）By Camphora, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Angelicae Sinensis go the removal of impurity, after cleaning-drying standby, take the chicken after cleaning
The egg yolk of egg is standby；
（2）Camphora, Radix Angelicae Sinensis, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi) are weighed by formula and is mixed, add 18 times of medical material gross weights
Water, after immersion 50min, decocts 3 hours, filters, obtain filtrate and filtering residue, standby；
（3）By step（2）In obtain filtrate slow fire heating, and in filtrate add Mel, be concentrated to give relative to the close of water
The thick paste for 1.38 is spent, standby；By step（2）In the filtering residue that obtains dry, be then ground to the powder of 300 mesh, in 60 DEG C of bars
10h is dried under part, and is fried to brown color using small fire, obtain medicated powder, standby；
（4）By step（3）The thick paste that obtains, medicated powder mixing, and egg yolk and Oleum Terebinthinae is added thereto to using syringe, stir
30min obtains ointment to mix homogeneously, standby.
（5）Coating step first on the internal layer of carrier（3）In medicated powder, then coating step on medicated powder（3）In be obtained
Thick paste, last coating step on thick paste（4）The ointment for obtaining, obtains semi-finished product；Semi-finished product are stood, standing is in humidity
For 4min being stood under the conditions of 24 DEG C of 57%, temperature, obtain final product Chinese medicine patch.
Embodiment seven
A kind of chilblain Chinese medicine note, including carrier and the ointment being arranged on carrier, carrier includes internal layer, outer layer, internal layer and outer layer
Between arrange remove wet layer, internal layer is non-woven fabrics, except wet layer be calcium sulfate, outer layer is waterproof material；Ointment is coated in internal layer, its
In, ointment includes the raw material of following weight portion：4.5 parts of Camphora, 38 parts of Folium Artemisiae Argyi, 28 parts of Pericarpium Zanthoxyli, 14 parts of Exocarpium Benincasae, 13 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi),
28 parts of Mel, 55 parts of egg yolk, 18 parts of Radix Angelicae Sinensis, 17 parts of Oleum Terebinthinae.
A kind of preparation method of chilblain Chinese medicine note, comprises the following steps：
（1）By Camphora, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Angelicae Sinensis go the removal of impurity, after cleaning-drying standby, take the chicken after cleaning
The egg yolk of egg is standby；
（2）Camphora, Radix Angelicae Sinensis, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi) are weighed by formula and is mixed, add 19 times of medical material gross weights
Water, after immersion 55min, decocts 3.5 hours, filters, obtain filtrate and filtering residue, standby；
（3）By step（2）In obtain filtrate slow fire heating, and in filtrate add Mel, be concentrated to give relative to the close of water
The thick paste for 1.39 is spent, standby；By step（2）In the filtering residue that obtains dry, be then ground to the powder of 300 mesh, in 63 DEG C of bars
11h is dried under part, and is fried to brown color using small fire, obtain medicated powder, standby；
（4）By step（3）The thick paste that obtains, medicated powder mixing, and egg yolk and Oleum Terebinthinae is added thereto to using syringe, stir
35min obtains ointment to mix homogeneously, standby.
（5）Coating step first on the internal layer of carrier（3）In medicated powder, then coating step on medicated powder（3）In be obtained
Thick paste, last coating step on thick paste（4）The ointment for obtaining, obtains semi-finished product；Semi-finished product are stood, standing is in humidity
For 4.5min being stood under the conditions of 24 DEG C of 58%, temperature, obtain final product Chinese medicine patch.
Embodiment eight
A kind of chilblain Chinese medicine note, including carrier and the ointment being arranged on carrier, carrier includes internal layer, outer layer, internal layer and outer layer
Between arrange remove wet layer, internal layer is non-woven fabrics, except wet layer be calcium sulfate, outer layer is waterproof material；Ointment is coated in internal layer, its
In, ointment includes the raw material of following weight portion：5 parts of Camphora, 40 parts of Folium Artemisiae Argyi, 30 parts of Pericarpium Zanthoxyli, 15 parts of Exocarpium Benincasae, 15 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), honeybee
30 parts of honey, 60 parts of egg yolk, 20 parts of Radix Angelicae Sinensis, 20 parts of Oleum Terebinthinae.
A kind of preparation method of chilblain Chinese medicine note, comprises the following steps：
（1）By Camphora, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Angelicae Sinensis go the removal of impurity, after cleaning-drying standby, take the chicken after cleaning
The egg yolk of egg is standby；
（2）Camphora, Radix Angelicae Sinensis, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi) are weighed by formula and is mixed, add 20 times of medical material gross weights
Water, after immersion 60min, decocts 4 hours, filters, obtain filtrate and filtering residue, standby；
（3）By step（2）In obtain filtrate slow fire heating, and in filtrate add Mel, be concentrated to give relative to the close of water
The thick paste for 1.40 is spent, standby；By step（2）In the filtering residue that obtains dry, be then ground to the powder of 300 mesh, in 65 DEG C of bars
12h is dried under part, and is fried to brown color using small fire, obtain medicated powder, standby；
（4）By step（3）The thick paste that obtains, medicated powder mixing, and egg yolk and Oleum Terebinthinae is added thereto to using syringe, stir
40min obtains ointment to mix homogeneously, standby.
（5）Coating step first on the internal layer of carrier（3）In medicated powder, then coating step on medicated powder（3）In be obtained
Thick paste, last coating step on thick paste（4）The ointment for obtaining, obtains semi-finished product；Semi-finished product are stood, standing is in humidity
For 5min being stood under the conditions of 25 DEG C of 60%, temperature, obtain final product Chinese medicine patch.
Clinical trial
First, case is tested
In recent years, face chilblain 249 is accepted for medical treatment altogether, and wherein male patient populations are 156, age gradient 3-72 year, female patient populations
For 93, age gradient is 4-65 year.
2nd, diagnostic criteria
Symptom includes：Extremity tip and exposure portion is apt to occur in, the patient brothers back side is common in, is distributed symmetrically, often have special rainbow
Film sample is damaged, and is found in sometimes face, buttockss, oral cavity etc..Show as that aubergine lump, Pi Wen are low, numb, heat is then to the cold
Itch, severe patient easily forms vesicle ulcer, after ulcer healing, leave atrophic cicatrix.
3rd, Therapeutic Method
Dry after skin is cleaned, the Chinese medicine patch of the present invention sticked on symptom position, every Chinese medicine patch drug effect continues 12 hours,
Five days be a course for the treatment of, clinical symptoms 1 course for the treatment of of lighter patient medication, 2 courses for the treatment of of heavier patient medication；Prohibit during treatment pungent,
Greasy, cold and cool food.
4th, the standard of curative effect evaluation
Cure：Each symptom all disappears, and chilblain skin is antipruritic, detumescence, the colour of skin are normal, without atrophy cicatrix.
Effective：Non-evident sympton and sign, relieving itching and eliminating swelling, but it is still redness at symptom.
Invalid：Subjective symptom and objective sign are without improvement.
5th, result
249 chilblain are treated, up to 97%, up to 93%, therapeutic effect is notable for cure rate for total effective rate.
Model case
Case 1：Lee, man, 3 years old, people from Henan Fangcheng, suffered from chilblain about one week at the winter in 2015, failed to understand in local repeatedly therapeutic effect
Aobvious, when going to a doctor to here, there is redness in patient's right hand middle finger joint, and with sufferings symptom.Using embodiments of the invention 4
External used medicine coat three days after, clinical symptom disappearance.The Effect of follow-up visit by telephone after two months that is discontinued did not recurred.
2. Dong, man, 16 years old, Tongbai in Henan Province people suffered from right hand hand side chilblain the year before, and after treatment, effect is not
Good, the winter in 2015 reappears chilblain in original position, and when going to a doctor to here, symptom is red and swollen, blister, and with pain symptom.
Coated after 1 course for the treatment of using the external used medicine of embodiments of the invention 4, clinical symptom disappearance.Be discontinued Effect of follow-up visit by telephone after two months
Do not recurred, skin scar phenomenon also do not occurred.
3. Lee so-and-so, man, 71 years old, Tongbai in Henan Province people, suffered from chilblain about ten days at the winter in 2015, to here medical when, patient
There is redness, is chapped from the cold in ears ear-lobe.Coated after 1 course for the treatment of using the external used medicine of embodiments of the invention 4, clinical symptoms disappear
Lose.The Effect of follow-up visit by telephone after two months that is discontinued did not recurred.
4. Ma, female, 23 years old, Nanyang, henan people came that I am gone to a doctor in the winter in 2014, and when going to a doctor, left symptom is that face is flushing
Swollen, stiff, local skin blacks.Coated after 2 courses for the treatment of using the external used medicine of embodiments of the invention 5, clinical symptom disappearance.
The Effect of follow-up visit by telephone after two months that is discontinued did not recurred.
5. Chen, female, 46 years old, Henan table mountain people from Lushan County came that I am gone to a doctor in the spring in 2016, when going to a doctor, left symptom
There is sufferings, ulcer for finger many places.Coated after 2 courses for the treatment of using the external used medicine of embodiments of the invention 5, clinical symptoms disappear
Lose, skin recovers as before.After being discontinued one month, Effect of follow-up visit by telephone did not recur.
Finally illustrate, only in order to technical scheme to be described and unrestricted, this area is common for above example
Other modifications or equivalent that technical staff is made to technical scheme, without departing from technical solution of the present invention
Spirit and scope, all should cover in the middle of scope of the presently claimed invention.
Claims (9)
1. chilblain Chinese medicine note, including carrier and the ointment being arranged on carrier, it is characterised in that the carrier includes the interior of bonding
Layer, outer layer, arrange between the internal layer and outer layer and remove wet layer, and the ointment includes the raw material of following weight portion：Camphora 3-5 parts,
Folium Artemisiae Argyi 20-40 parts, Pericarpium Zanthoxyli 10-30 parts, Exocarpium Benincasae 5-15 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 5-15 parts, Mel 20-30 parts, egg yolk 40-60 parts, Radix Angelicae Sinensis
10-20 parts, Oleum Terebinthinae 10-20 parts.
2. chilblain Chinese medicine note according to claim 1, it is characterised in that the internal layer is non-woven fabrics, described except wet layer be
Calcium chloride or calcium sulfate, the outer layer are waterproof material.
3. chilblain Chinese medicine note according to claim 1, it is characterised in that the ointment includes the raw material of following weight portion：
Camphora be 4 parts, 30 parts of Folium Artemisiae Argyi, 20 parts of Pericarpium Zanthoxyli, 10 parts of Exocarpium Benincasae, 10 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 25 parts of Mel, 50 parts of egg yolk, 15 parts of Radix Angelicae Sinensis, pine
15 parts of fuel-economizing.
4. chilblain Chinese medicine note according to claim 1, it is characterised in that leaf of the Folium Artemisiae Argyi for Qi Ai.
5. a kind of preparation method of the chilblain Chinese medicine note according to any one of claim 1-4, it is characterised in that including following
Step：
（1）By Camphora, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Angelicae Sinensis go the removal of impurity, after cleaning-drying standby, take the chicken after cleaning
The egg yolk of egg is standby；
（2）Camphora, Radix Angelicae Sinensis, Folium Artemisiae Argyi, Pericarpium Zanthoxyli, Exocarpium Benincasae, Cortex cinnamomi japonici (Ramulus Cinnamomi) is weighed, the water of 15-20 times of medical material gross weight is added, 30- is soaked
After 60min, 2-4 hours are decocted, filter, obtain filtrate and filtering residue, standby；
（3）By step（2）In obtain filtrate slow fire heating, and in filtrate add Mel, be concentrated to give relative to the close of water
The thick paste for 1.36-1.40 is spent, standby；By step（2）In the filtering residue that obtains dry, be then ground to powder, in 60-65 DEG C of bar
Dry under part, reuse small fire and fry to brown color, obtain medicated powder, standby；
（4）By step（3）The thick paste that obtains, medicated powder mixing, and be added thereto to egg yolk and Oleum Terebinthinae, stirring 20-40min is to mixed
Close uniformly, obtain ointment, standby；
（5）Coating step first on the internal layer of carrier（3）In medicated powder, then coating step on medicated powder（3）In obtained thick
Cream, finally coating step on thick paste（4）The ointment for obtaining, obtains semi-finished product；Semi-finished product are stood, Chinese medicine patch is obtained final product.
6. the preparation method of chilblain Chinese medicine note according to claim 5, it is characterised in that step（1）Middle egg is cleaned
After carry out disinfection, after broken shell using disposable syringe extract egg yolk standby.
7. the preparation method of chilblain Chinese medicine note according to claim 5, it is characterised in that step（3）Described in dry temperature
6-12h is dried under the conditions of 50-60 DEG C of degree.
8. the preparation method of chilblain Chinese medicine note according to claim 5, it is characterised in that step（3）Described in medicated powder
Particle diameter is 250-300 mesh.
9. the preparation method of chilblain Chinese medicine note according to claim 5, it is characterised in that step（5）Described in stand be
It is 50%-60%, stands 3-5min under the conditions of temperature 20-25 DEG C in humidity.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114277569A (en) * | 2021-02-20 | 2022-04-05 | 段清洌 | Moxa cotton, preparation method thereof, moxa cotton slow-release chest and abdomen underwear containing moxa cotton, and production method |
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| CN105963452A (en) * | 2016-06-24 | 2016-09-28 | 南阳医学高等专科学校第附属医院 | Traditional Chinese medicine patch for treating infantile cold cough and preparation method thereof |
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| CN114277569A (en) * | 2021-02-20 | 2022-04-05 | 段清洌 | Moxa cotton, preparation method thereof, moxa cotton slow-release chest and abdomen underwear containing moxa cotton, and production method |
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Application publication date: 20170315 |