CN106474413A - A kind of Orally administered composition for treating child's weakness of the spleen and stomach, eating accumulation, anorexia - Google Patents
A kind of Orally administered composition for treating child's weakness of the spleen and stomach, eating accumulation, anorexia Download PDFInfo
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Abstract
The present invention relates to a kind of Orally administered composition for treating child's weakness of the spleen and stomach, eating accumulation, anorexia, inappetence, diet minimizing, described compositionss, it is prepared from by following raw material of Chinese medicine medicine：Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus, the Radix Paeoniae Alba, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Aucklandiae, Fructus Amomi, Rhizoma Corydalis, Radix Glycyrrhizae Preparata.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, it is used for treating child's weakness of the spleen and stomach, eating accumulation, detests particularly to one kind
The Orally administered composition that food, inappetence, diet reduce.
Background technology
Infantile anorexia (anorexia) refers to that longer loss of appetite or disappearance, appetite are reduced to cardinal symptom, is
Common disease in children now.Severe patient can cause malnutrition and multivitamin and trace element deficiency, affects children
Growth promoter.
Symptom and sign
1. the age：The baby of less than 1 year old, particularly neonate has the low person of obvious appetite, mostly caused by disease, especially should
Note septicemia, tuberculosis, ricketss and various food deficiency disease etc..Child and Annual wool yield will pay special attention to various bad diet
The impact of the psychoneural factor such as custom and emotion.
2. home environment situation：The preferable children of domestic conditions, because too spoiling, too worry child health and nutrition,
Take trick, curse and beat, many to methods such as snacks, attempt allows and eats children more, and result is often run counter to desire；Some father and mother are inadequate to children
It is concerned about, affect children's emotion and appetite.
3. the degree of loss of appetite：Slight off feed is probably normal individual difference or the bad habit institute such as snacks are excessive
The presence of potential disease is often pointed out in cause, serious loss of appetite or refusing to eat.
4. have or not simultaneous phenomenon：Though there being slight off feed, children are active, happy, energetic asymptomatic person, mostly
Normally.With tired, lethargy, low grade fever person, polyphyly tuberculosis or other infection.With abdomen pain and the person of having blood in stool it should be noted that stomach, ten
Two Duodenalulcers, parasite etc..With bradykinesia, pachylosiies, hypohidrosis and dysplasia person are it should be noted that thyroid function is low
Under.With skeleton change system ricketss such as hyperhidrosis, beading of ribs, square volume, craniotabess.
Medication is treated
1. reasonable feeding：Conduct vigorous propaganda seientific child-bearing knowledge, accomplish reasonable feeding.Baby within 4 months preferably with
Pure breast feeding.The children of Pure breast feeding seldom have anorexia.Rationally add diatery supplement in order, must not act with undue haste.Children drink
Food, based on main non-staple food, does not disorderly add extra " nutraceutical ".
2. cultivate good dietetic hygiene habit：Regularly, press a feed, do not eat a piece (inclusion beverage) before meals, in order to avoid blood
Sugar raises impact appetite, eats fruit after meal, afternoon nap of wakeing up can be concentrated and be eaten a little cakes and confection.The head of a family is it is noted that frequent conversion is drunk
Food variety, meat and vegetables collocation, must not monophagia.Keep carefree feed emotion.Because of various reasons, even if having several times
Infantile appetite is bad, does not also worry, infantile appetite of must not threatening and intimidating, and also must not beg infantile appetite.One meal do not eat, need not
Misgivings, also must not be supplemented with snacks, the lower meal nature that is hungry can be eaten again.
3. Cure the Primary Disease：As the anorexia causing for general disease, after protopathy is cured, appetite can increase naturally.
4. disable antibiotic and the other drugs causing gastrointestinal reaction.
5. correct trace element deficiency：If there being zinc deficiency, oral zinc gluconate, daily 1～1.5mg/kg, 2 times/d are administered orally.
6. digester：Oral pepsin mixture or yeast tablet have certain effect to appetite stimulator.
7. medicine for stomach dynamic：As Domperidone (motilium), Lower esophageal ephincter tension force can be improved, promote gastric peristalsis, plus
Fast gastric emptying, can mitigate abdominal distention, prevent Nausea and vomiting, have preferable effect to the anorexia that gastrointestinal motility disorder causes.Dosage：
0.3mg/kg every time, 3 times/d are administered orally.The course for the treatment of 4 weeks.
8. hormonotherapy：General without application is contemplated that to serious intractable apositia：1. prednisone (prednisone).Often
Its 0.5mg/kg, 3 times/d are administered orally.2. low-dose insulin, for intractable anorexia, Insulin 3～6U is added on 10% glucose
250～500ml intravenous drip (1U insulin at least gives glucose 4g), all can increase appetite.
9. acupuncture and chiropractic therapy：There is certain effect.
10. anorexia nervosa treatment：First have to eliminate the various direct stimulation factors causing infant not peaceful.Change incorrect
Educational method, make infant produce good emotion.There is preferable effect with acupuncture cooperation verbal suggestion.Conventional acupuncture point is sleeping
2nd, tsu san li, connected valleys etc..
Abroad adopt antidepressants, amitriptyline (Amitriptyline), to improve the emotion of infant, improve infant
Interest to feed.Dosage：12.5～25mg/kg, is administered orally, 1 time every night, 0.5～1h clothes before sleeping.Typically after 6～12 days
Take effect.Additionally, antihistaminic and antiserotonin, Cyproheptadine (Cyproheptadine), can have one as appetite analeptic
Determine effect.Dosage：Daily 0.25mg/kg, divides 2～3 times and is administered orally.
The method of existing Chinese medicine infantile anorexia includes：
1. dyspepsia stagnation, incoordination between the spleen and stomach：Main symptom：Inappetence, Nausea and vomiting, told kill and devour, sour in the mouth smelly.Loose stool does not disappear
Change, nursing infant has milk lobe, or constipation.Distension and fullness in the abdomen, or have stomachache, agitation is cried well, and night sleeps unreal.Tongue is yellowish greasy, and rolling pulse has
Power.The rule for the treatment of：Dyspepsia and intestinal stasis relieving, invigorating the spleen and regulating the stomach.Prescription：Lenitive pill is added and subtracted.Common medicine：Herba Pogostemoniss, Pericarpium Citri Reticulatae, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Semen Raphani, sand
Core, Poria.Dysphoria, night are slept unreal：Plus Ramulus Uncariae Cum Uncis, Concha Margaritifera.Dry stool：Change burnt four celestial.Constipation：Plus Radix Et Rhizoma Rhei.
2. spleen is lacked of proper care by wet tired, transporting：Main symptom：It is more common in big child, once suffered from summer-heat damp cold, shallow complexion in the recent period, body is stranded
Weak, greasy taste in the mouth is dull, not yearningly, or has loose stool.Tongue is greasy in vain to be abound with, relaxed and soft pulse.The rule for the treatment of：Stomach function regulating in the spleen strengthening and damp drying, tune.Prescription：Three
Core Tonga subtracts.Common medicine：Semen Armeniacae Amarum, Semen Coicis, Fructus Amomi Rotundus, Pericarpium Citri Reticulatae, Talcum, Poria, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Fructus Amomi, Herba Pogostemoniss.
3. congenital defect, vigour are weak：Main symptom：Baby's premature labor, after life, sob is faint, and breath is humble, and skin is soft powerless,
Complexion HUANGBAI(sic), light red tongue, white and thin fur, thready and weak pulse.The rule for the treatment of：Stomach function regulating in invigorating the spleen and benefiting QI, tune.Prescription：SHENLING BAISHU SAN is added and subtracted.Conventional
Medicine：Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Fructus Amomi, stir-fry paddy Fructus Hordei Germinatus.
4. stagnate with the passing of time, cloudy liquid consume：Main symptom：Emaciated physique, inappetence, thirst and liking drink, two cheeks are rubescent, Shou Zuxin
Heat, tired urgency is cried well, unreal, the night sweat of night dormancy.Red tongue lacks tongue or strips off (geographic tongue), thready and rolling pulse.The rule for the treatment of：Nourishing YIN and clearing away heat, mind calming
Calm the nerves.Common medicine：The Radix Rehmanniae, Radix Scrophulariae, pollen, Herba Dendrobii, Pericarpium Citri Reticulatae, Fructus Amomi, Poria, Endothelium Corneum Gigeriae Galli.Dysphoria, night are slept unreal：Plus hook
Rattan, Concha Margaritifera.
5. liver-heat is insufficiency of the spleen：Main symptom：Become thin poor appetite, impatient cry well, night sleeps uneasiness, and body of the tongue is light red, white and thin fur, above old tooth on
Palate yellow, thready and rolling pulse.The rule for the treatment of：Liver heat removing spleen invigorating.Common medicine：Indigo Naturaliss, Radix Arnebiae (Radix Lithospermi), Massa Medicata Fermentata, Fructus Crataegi (parched to brown), Flos Caryophylli, Fructus Amomi.Tired urgency cries well,
Night sleeps uneasiness：Plus Ramulus Uncariae Cum Uncis, Concha Margaritifera.
Prior art such as Hubei College Of Traditional Chinese Medicine's journal, Hubei Journal of Traditional Chinese Medicine, Journal of Chinese Hospital Pharmacy etc. discloses one kind
The peaceful oral liquid of taste, its by:Fructus Crataegi (parching to brown) 75g, Massa Medicata Fermentata (parching to brown) 75g, Fructus Hordei Germinatus (parching to brown) 75g, Radix Paeoniae Alba 125g, Radix Codonopsis
75g, Poria 75g, the medicine such as the Rhizoma Atractylodis Macrocephalae (stir-fry) 42g forms.With JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) as monarch drug in side, i.e. the main meat that disappears of the sweet temperature of Fructus Crataegi (parched to brown) acid,
Massa Medicata Fermentata (parched to brown) master disappears wheaten food, and Fructus Hordei Germinatus (parched to brown) master disappears rice food.The Radix Paeoniae Alba, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae are ministerial drug altogether, and Radix Paeoniae Alba sour in the mouth is cold in nature, yin fluid astringing benefit
The moon, and can relieving spasm to stop pain；Radix Codonopsis sweet in the mouth is mild-natured, invigorating the spleen and replenishing QI, coordinates Poria, the Rhizoma Atractylodis Macrocephalae, makes invigorating the spleen and regulating the stomach, making source is enriched, main
Control infantile anorexia and belong to insufficiency of the spleen indigestion type person.
Other document discloses a kind of peaceful oral liquid of taste, with JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) as monarch drug, i.e. the main meat that disappears of the sweet temperature of Fructus Crataegi (parched to brown) acid
Food, Massa Medicata Fermentata (parched to brown) master disappears wheaten food, and Fructus Hordei Germinatus (parched to brown) master disappears rice food；The Radix Paeoniae Alba, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae are ministerial drug altogether, and Radix Paeoniae Alba sour in the mouth is cold in nature, holds back
Cloudy tonifying YIN, join Radix Glycyrrhizae more sour and sweet drugs can transforme into YIN, and can relieving spasm to stop pain, Radix Codonopsis sweet in the mouth, mild-natured, invigorating the spleen and replenishing QI, cooperation Poria, the Rhizoma Atractylodis Macrocephalae,
Radix Glycyrrhizae invigorating the spleen and regulating the stomach, changes source and enriches；The Radix Aucklandiae, Fructus Amomi, Rhizoma Corydalis are adjuvant drug, qi-regulating relieving distension, pain relieving of being amusing of whetting the appetite；Radix Glycyrrhizae sweet in the mouth,
Mild-natured, invigorating the spleen and replenishing QI, and energy coordinating the actions of various ingredients in a prescription, therefore be adjuvant.All formulas are matched, and work(can dyspepsia and intestinal stasis relieving, regulating QI to relieve pain, spleen invigorating benefit
Gas.
But formulation ratio and preparation method that above-mentioned document is not disclosed about, the present invention finds through research, above-mentioned
The not good impact child administration of formula mouthfeel, medicine stability is poor, and has gastrointestinal reaction.
The present invention on the basis of existing technology, is dug to drug ratio of the prior art and preparation method
Pick, development is a kind of to treat the ideal effective new Chinese medicine of infantile anorexia.
Content of the invention
The present invention relates to a kind of for treat child's weakness of the spleen and stomach, eating accumulation, anorexia, inappetence, appetite reduce
Orally administered composition, described compositionss, it is prepared from by following raw material of Chinese medicine medicine：Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus, the Radix Paeoniae Alba, Radix Codonopsis, Fu
Siberian cocklebur, the Rhizoma Atractylodis Macrocephalae, the Radix Aucklandiae, Fructus Amomi, Rhizoma Corydalis, Radix Glycyrrhizae Preparata.
The Orally administered composition of the present invention, is preferably prepared from by the raw material of Chinese medicine medicine of following weight proportion：
Fructus Crataegi (parching to brown) 10-18 weight portion, Massa Medicata Fermentata (parching to brown) 10-18 weight portion, Fructus Hordei Germinatus (parching to brown) 12-20 weight portion,
Radix Paeoniae Alba 20-28 weight portion, Radix Codonopsis 12-18 weight portion, Poria 8-18 weight portion, the Rhizoma Atractylodis Macrocephalae (stir-fry) 6-10 weight portion, Radix Aucklandiae 6-12 weight
Amount part, Fructus Amomi 2-8 weight portion, Rhizoma Corydalis (vinegar system) 10-18 weight portion, Radix Glycyrrhizae Preparata 8-15 weight portion.
Most preferably, described compositionss, are prepared from by the raw material of Chinese medicine medicine of following weight proportion：
Fructus Crataegi (parching to brown) 15 weight portion, Massa Medicata Fermentata (parching to brown) 15 weight portion, Fructus Hordei Germinatus (parching to brown) 15 weight portion, the Radix Paeoniae Alba 25 weight
Part, Radix Codonopsis 15 weight portion, Poria 15 weight portion, the Rhizoma Atractylodis Macrocephalae (stir-fry) 8.5 weight portion, the Radix Aucklandiae 8 weight portion, Fructus Amomi 6 weight portion, Rhizoma Corydalis
(vinegar system) 12 weight portion, Radix Glycyrrhizae Preparata 10 weight portion.
Orally administered composition of the present invention, can include any pharmaceutical dosage form for being administered orally, such as：Tablet, capsule,
Granule, oral liquid, drop pill, pill etc., currently preferred dosage form is oral liquid.
The present invention, when being prepared into the pharmaceutical dosage form for being administered orally, can add suitable medicine to be subjected to as needed
Carrier, such as Microcrystalline Cellulose, starch, dextrin, sucrose, stachyose, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, poly-
Ethylene glycol, Polyvinylpyrrolidone, Pulvis Talci, magnesium stearate, sorbitan mono-oleic acid ester, glycine, gelatin, glycerol, water, right
Nipagin A, LaspartylLphenylalanine methylester, sorbic acid, Tweenses.
The present invention further provides the preparation method of the present composition, methods described step is as follows：
Step 1, Fructus Amomi, the Radix Aucklandiae, Rhizoma Atractylodis Macrocephalae water extraction simultaneously collects volatile oil；
Step 2, is collected the medicinal residues medicinal liquid after volatile oil and is jointly added water to cook 1-3 time with remaining medical material, each 1-3 hour,
Decoction liquor filters, and concentrates, obtains concentrated solution；
Step 3, concentrated solution adds ethanol makes alcohol content reach 40-80%, and 8-96 hour is placed in cold preservation, filters after precipitate with ethanol, filter
Liquid decompression recycling ethanol is to no alcohol taste；Obtain no alcohol liquid；
Step 4, no alcohol liquid add step 1 gained volatile oil, mix with pharmaceutically acceptable carrier, are prepared into oral formulations
Compositionss.
Preferably, the preparation method of the present invention, step is as follows：
Step 1, Fructus Amomi, the Radix Aucklandiae, the Rhizoma Atractylodis Macrocephalae adds 8-40 times amount water, extracts and collects volatile oil；
Step 2, is collected the medicinal residues medicinal liquid after volatile oil and is jointly added water to cook 2-3 time with remaining medical material, add water 6-10 every time
Times, decocting time 1-3 hour, merge decoction liquor, filtration, concentrate；
Step 3, plus ethanol makes alcohol content reach 55-75%, cold preservation 10-48 hour, Precipitation, filtration, filtrate decompression
Reclaim ethanol to no alcohol taste, obtain no alcohol liquid
Step 4, adds volatile oil and proper amount of surfactant, adds taurine 1-2g, aspartoyl Phenylalanine first
Ester or appropriate sucralose, Preservative qs, are adjusted to total amount 1000ml, cold preservation with distilled water, filter,
Filtrate fill, sterilizing, thus obtaining the product.
The present invention has carried out many research to formula, technique on the basis of existing technology, and carries out contrast experiment,
Find that medicine of the present invention is better than prior art many-sided.As added taurine 1g to improve mouthfeel, stability improves.
Below by way of experimental data, beneficial effects of the present invention are described：
First, inventive formulation garbled data：
Experiment 1, the impact to small intestine movement of mice carbon powder propulsion rate
Experimental result is as follows：
Table 1
The present invention is found surprisingly that the Radix Aucklandiae in 1 group of the embodiment of the present invention, Fructus Amomi, Rhizoma Corydalis (vinegar system), the agent of Radix Glycyrrhizae Preparata
Amount controls in Radix Aucklandiae 6-12 weight portion, Fructus Amomi 2-8 weight portion, Rhizoma Corydalis (vinegar system) 10-18 weight portion, Radix Glycyrrhizae Preparata 8-15 weight portion
Ratio between excellent effect, other ratio effects are poor.
Experiment 2, the impact to syndrome of spleen-deficiency mouse small intestine carbon powder propulsion rate
Experimental result is as follows：
Table 2
The present invention is found surprisingly that the Radix Aucklandiae in 1 group of the embodiment of the present invention, Fructus Amomi, Rhizoma Corydalis (vinegar system), the agent of Radix Glycyrrhizae Preparata
Amount controls in Radix Aucklandiae 6-12 weight portion, Fructus Amomi 2-8 weight portion, Rhizoma Corydalis (vinegar system) 10-18 weight portion, Radix Glycyrrhizae Preparata 8-15 weight portion
Ratio between excellent effect, other ratio effects are poor.
2nd, preparation method screening experiment data of the present invention：
1st, efficacy experiment：Totally 348
Table 3
2nd, untoward reaction, totally 348 patients
Table 4
| Index 1 | Index 2 | Index 3 | Index 4 | |
| Diarrhoea | Respiratory tract infection | Erythra | Skin pruritus | |
| Embodiment 1 medicine | 1 | 1 | 1 | 1 |
| Comparative example 1 | 4 | 5 | 2 | 3 |
| Comparative example 2 | 3 | 4 | 3 | 6 |
| Comparative example 3 | 5 | 2 | 2 | 2 |
3rd, mouthfeel experiment：
Table 5
4th, medicine stability experiment：
Table 6
The present invention, after having carried out improvements over the prior art and having improved, has been also carried out many pharmacodynamic experiments,
Experimental result is as follows：
Experimental agents：
Positive control is the Chinese patent medicine of listing that certain contains the Chinese medicinal components such as Poria, Endothelium Corneum Gigeriae Galli (parched), and medicine of the present invention adopts
The medicine of the embodiment of the present invention 1 preparation is referred to as Massa Medicata Fermentata digestion promoting oral liquid.
Experiment 1, Massa Medicata Fermentata digestion promoting oral liquid is to normal and mice with spleen deficiency intestinal propulsion impact
Experimental technique：Kunming mouse 150, is divided into two batches, body weight 18-19g, male and female half and half.First 70 points 5
Group, packet situation is：1 Normal group, 2 positive controls, 3-5 Massa Medicata Fermentata digestion promoting oral liquid 11.7,5.8,2.9g/kg group；The
Two batches points 6 groups, i.e. 1 Normal group, 2 model of spleen deficiency groups, 3 insufficiency of the spleen+positive controls, 4-6 is insufficiency of the spleen+Massa Medicata Fermentata digestion promoting oral liquid
11.7th, 5.8,2.9g/kg make intemperance of taking food type spleen deficiency model, continuous 10 days, administration and test method two batches animal identical,
Following narration：The equal successive administration of two batches animal 5 days, fasting before not secondary administration can't help water 15 hours, and gavage is suspended to 5% carbon powder
Liquid (being prepared with 1% arabic gum) 0.2ml/10g.Put to death mice to dislocation after carbon powder 15 minutes.Take mouse small intestine from pylorus extremely
Return blind section, measurement small intestinal total length and carbon powder move ahead distance in enteral, calculate carbon powder propulsion rate.Group difference is compared in T inspection.Result
It is shown in Table 7, table 8.
Impact that table 7 Massa Medicata Fermentata digestion promoting oral liquid advances to small intestine movement of mice (%)
Note：Compare * p with Normal group<0.05 **p<0.01
Impact that table 8 Massa Medicata Fermentata digestion promoting oral liquid advances to spleen deficiency mouse small intestine (%)
Note：Compare * p with model of spleen deficiency group<0.05 **p<0.01
Result shows：Massa Medicata Fermentata digestion promoting oral liquid 11.7g/kg, 5.8g/kg dosage has to small intestine movement of mice and significantly pushes away
Enter effect；Massa Medicata Fermentata digestion promoting oral liquid 5.8g/kg, 2.9g/kg dosage significantly promotes to make to the small intestinal tool of spleen deficiency model mice
With being allowed to close to normal level, effect is better than positive controls.
Experiment 2, the impact to mouse small intestine absorption function and amylase activity for the Massa Medicata Fermentata digestion promoting oral liquid
Kunming mouse, body weight 18-20g, male and female half and half.It is randomly divided into 5 groups by body weight, that is,：1 Normal group, 2 is positive
Matched group, 3-5 Massa Medicata Fermentata digestion promoting oral liquid 11.7,2.9,0.73g/kg group, successive administration 5 days, water is can't help in fasting before last dose
18 hours, after last dose, 1 hour each group mice difference gavage was to 10%D- xylose 0.4ml/20g.Posterior orbit takes blood within 1 hour,
Prepare serum, colorimetry surveys diastatic activity in serum.Separately part serum is prepared nonprotein filtrate.O- toluidines improvement
Method measures D Xylose Content in serum, and computational methods are as follows.Group difference is compared in T inspection.The results are shown in Table 9
Table 9 Massa Medicata Fermentata digestion promoting oral liquid to mice xylose absorb and amylase activity impact (%)
Note：Compare * p with Normal group<0.05 **p<0.01
Result shows：11.7th, 2.9g/kg dosage Massa Medicata Fermentata digestion promoting oral liquid and certain contain the Chinese medicine group such as Poria, Endothelium Corneum Gigeriae Galli (parched)
That divides lists the Small Intestinal that Chinese patent medicine all can significantly increase mice, and has the effect improving amylase activity.
Experiment 3, the impact to spleen deficiency mice gastric emptying caused by intemperance of taking food for the Massa Medicata Fermentata digestion promoting oral liquid
Kunming mouse, body weight 19-21g, it is randomly divided into 6 groups by body weight, packet situation is shown in Table 10.Make spleen deficiency model same
Aforementioned.Successive administration 5 days, fasting before not secondary administration can't help water 18 hours, and latter 1 hour gavage of administration gives 0.05% phenol red solution
0.2ml/10g (1% arabic gum prepare), cuts stomach after ligation cardia after 20 minutes, pylorus, puts 40ml 0.1mol/L NaOH
In solution, shred, stand 60 minutes, take supernatant 5ml to add 20% trichloroacetic acid 0.5ml, 2500 revs/min are centrifuged 5 minutes, take
Clear liquid 1ml adds 0.5mol/L NaOH4ml colour developing, colorimetric at 560nm.Put to death immediately after separately taking 4 blank mouse stomaches phenol red and take
Stomach, same to pre-treatment, as zero point comparison.Gastric emptying rate computational methods are as follows, and group difference is compared in t inspection.The results are shown in Table 10
The impact to spleen deficiency mice gastric emptying for the table 10 Massa Medicata Fermentata digestion promoting oral liquid (%)
Note：Compare * p with model of spleen deficiency group<0.05 **p<0.01
Result shows：The each dosage group of Massa Medicata Fermentata digestion promoting oral liquid is respectively provided with obvious promotion to spleen deficiency model mice gastric emptying
Effect
Experiment 4, the impact to rat gastric secretion for the Massa Medicata Fermentata digestion promoting oral liquid
Healthy Wistar strain rats, body weight 180-200g, male and female half and half, divide 5 groups, i.e. 1 Normal group, 2 is positive right
According to group, 3-5 Massa Medicata Fermentata digestion promoting oral liquid 6.6,2.2,0.73g/kg group (9,3,1 times of quite clinical consumption per day), continuous gavage is given
Medicine 3 days, fasting before test can't help water 18 hours.Ether light anesthesia rat, routine disinfection, carefully lift stomach, tie at pylorus
Prick, the corresponding medicinal liquid of 1ml/100g of duodenum injection simultaneously, Normal group injects isometric(al) distilled water, sends back to after sewing-up cut
In cage, water is can't help in postoperative fasting, and after 4 hours, de- cervical vertebra puts to death animal, ligatures cardia, takes out stomach, collects gastric juice and is centrifuged in scale
Pipe, is centrifuged 10 minutes with 3000 revs/min, measures stomach liquid measure, with phenolphthalein one step titration measuring total acidity gastric juice, Mett method mensure
Pepsin activity.Computational methods are as follows.Group difference is compared in T inspection.
The NaOH amount X10 that total acidity (mEq/L)=titration consumes
Pepsin activity unit=meansigma methodss2×16
The impact to rat stomachial secretion for the table 11 Massa Medicata Fermentata digestion promoting oral liquid (%, n=10)
Note：Compare * p with Normal group<0.05 **p<0.01
Result shows：Massa Medicata Fermentata digestion promoting oral liquid 6.6,2.2g/kg dosage group have obvious increase pepsin activity
Effect
Specific embodiment
Further illustrate the present invention by the following examples.
Embodiment 1
Formula：
Fructus Crataegi (parching to brown) 15 weight portion, Massa Medicata Fermentata (parching to brown) 15 weight portion, Fructus Hordei Germinatus (parching to brown) 15 weight portion, the Radix Paeoniae Alba 25 weight
Part, Radix Codonopsis 15 weight portion, Poria 15 weight portion, the Rhizoma Atractylodis Macrocephalae (stir-fry) 8.5 weight portion, the Radix Aucklandiae 8 weight portion, Fructus Amomi 6 weight portion, Rhizoma Corydalis
(vinegar system) 12 weight portion, Radix Glycyrrhizae Preparata 10 weight portion
The preparation method of oral liquid, step is as follows：
Step 1, Fructus Amomi, the Radix Aucklandiae, the Rhizoma Atractylodis Macrocephalae adds 8-40 times amount water, extracts and collects volatile oil；
Step 2, is collected the medicinal residues medicinal liquid after volatile oil and is jointly added water to cook 2-3 time with remaining medical material, add water 6-10 every time
Times, decocting time 1-3 hour, merge decoction liquor, filtration, concentrate；
Step 3, plus ethanol makes alcohol content reach 55-75%, cold preservation 10-48 hour, Precipitation, filtration, filtrate decompression
Reclaim ethanol to no alcohol taste, obtain no alcohol liquid
Step 4, adds volatile oil and proper amount of surfactant
Step 5, plus taurine 1g, appropriate LaspartylLphenylalanine methylester, Preservative qs；
Step 6, the product mixing of step 3-5, it is adjusted to total amount 1000ml, cold preservation, filtration, filtrate fill with distilled water, go out
Bacterium obtains final product.
Embodiment 2
Formula：
Fructus Crataegi (parching to brown) 12 weight portion, Massa Medicata Fermentata (parching to brown) 12 weight portion, Fructus Hordei Germinatus (parching to brown) 12 weight portion, the Radix Paeoniae Alba 23 weight
Part, Radix Codonopsis 14 weight portion, Poria 14 weight portion, the Rhizoma Atractylodis Macrocephalae (stir-fry) 7 weight portion, the Radix Aucklandiae 7 weight portion, Fructus Amomi 4 weight portion, Rhizoma Corydalis
(vinegar system) 10 weight portion, Radix Glycyrrhizae Preparata 8 weight portion
The preparation method of oral liquid, step is as follows：
Step 1, Fructus Amomi, the Radix Aucklandiae, the Rhizoma Atractylodis Macrocephalae adds 8-40 times amount water, extracts and collects volatile oil；
Step 2, is collected the medicinal residues medicinal liquid after volatile oil and is jointly added water to cook 2-3 time with remaining medical material, add water 6-10 every time
Times, decocting time 1-3 hour, merge decoction liquor, filtration, concentrate；
Step 3, plus ethanol makes alcohol content reach 55-75%, cold preservation 10-48 hour, Precipitation, filtration, filtrate decompression
Reclaim ethanol to no alcohol taste, obtain no alcohol liquid
Step 4, adds volatile oil and proper amount of surfactant
Step 5, adds LaspartylLphenylalanine methylester and Preservative qs；
Step 6, the product mixing of step 3-5, it is adjusted to total amount 1000ml, cold preservation, filtration, filtrate fill with distilled water, go out
Bacterium obtains final product.
Embodiment 3
Formula：
Fructus Crataegi (parching to brown) 17 weight portion, Massa Medicata Fermentata (parching to brown) 17 weight portion, Fructus Hordei Germinatus (parching to brown) 17 weight portion, the Radix Paeoniae Alba 28 weight
Part, Radix Codonopsis 18 weight portion, Poria 18 weight portion, the Rhizoma Atractylodis Macrocephalae (stir-fry) 10 weight portion, the Radix Aucklandiae 10 weight portion, Fructus Amomi 8 weight portion, Rhizoma Corydalis
(vinegar system) 17 weight portion, Radix Glycyrrhizae Preparata 14 weight portion
The preparation method of oral liquid, step is as follows：
Step 1, Fructus Amomi, the Radix Aucklandiae, the Rhizoma Atractylodis Macrocephalae adds 8-40 times amount water, extracts and collects volatile oil；
Step 2, is collected the medicinal residues medicinal liquid after volatile oil and is jointly added water to cook 2-3 time with remaining medical material, add water 6-10 every time
Times, decocting time 1-3 hour, merge decoction liquor, filtration, concentrate；
Step 3, plus ethanol makes alcohol content reach 55-75%, cold preservation 10-48 hour, Precipitation, filtration, filtrate decompression
Reclaim ethanol to no alcohol taste, obtain no alcohol liquid
Step 4, adds volatile oil and proper amount of surfactant
Step 5, adds LaspartylLphenylalanine methylester and Preservative qs；
Step 6, the product mixing of step 3-5, it is adjusted to total amount 1000ml, cold preservation, filtration, filtrate fill with distilled water, go out
Bacterium obtains final product.
Comparative example 1
Formula：
Fructus Crataegi (parching to brown) 15 weight portion, Massa Medicata Fermentata (parching to brown) 15 weight portion, Fructus Hordei Germinatus (parching to brown) 15 weight portion, the Radix Paeoniae Alba 25 weight
Part, Radix Codonopsis 15 weight portion, Poria 15 weight portion, the Rhizoma Atractylodis Macrocephalae (stir-fry) 8.5 weight portion, the Radix Aucklandiae 8 weight portion, Fructus Amomi 6 weight portion, Rhizoma Corydalis
(vinegar system) 12 weight portion, Radix Glycyrrhizae Preparata 10 weight portion
The preparation method of oral liquid, step is as follows：
Step 1, above 11 tastes add 6-10 times of water, decoct 2-3 time, decocting time 1-3 hour, merge decoction liquor, filter, dense
Contracting；
Step 2, plus ethanol makes alcohol content reach 55-75%, cold preservation 10-48 hour, Precipitation, filtration, filtrate decompression
Reclaim ethanol to no alcohol taste, obtain no alcohol liquid
Step 3, adds surfactant, LaspartylLphenylalanine methylester and Preservative qs；
Step 4, the product mixing of step 1-3, it is adjusted to total amount 1000ml, cold preservation, filtration, filtrate fill with distilled water, go out
Bacterium obtains final product.
Comparative example 2
Formula：
Fructus Crataegi (parching to brown) 15 weight portion, Massa Medicata Fermentata (parching to brown) 15 weight portion, Fructus Hordei Germinatus (parching to brown) 15 weight portion, the Radix Paeoniae Alba 25 weight
Part, Radix Codonopsis 15 weight portion, Poria 15 weight portion, the Rhizoma Atractylodis Macrocephalae (stir-fry) 8.5 weight portion, the Radix Aucklandiae 8 weight portion, Fructus Amomi 6 weight portion, Rhizoma Corydalis
(vinegar system) 12 weight portion, Radix Glycyrrhizae Preparata 10 weight portion
The preparation method of oral liquid, step is as follows：
Step 1, above 11 tastes add 6-10 times of water, decoct 2-3 time, decocting time 1-3 hour, merge decoction liquor, filter, dense
Contracting；
Step 2, adds surfactant, LaspartylLphenylalanine methylester and Preservative qs；
Step 3, the product mixing of step 1-2, it is adjusted to total amount 1000ml, cold preservation, filtration, filtrate fill with distilled water, go out
Bacterium obtains final product.
Comparative example 3
Formula：
Fructus Crataegi (parching to brown) 15 weight portion, Massa Medicata Fermentata (parching to brown) 15 weight portion, Fructus Hordei Germinatus (parching to brown) 15 weight portion, the Radix Paeoniae Alba 25 weight
Part, Radix Codonopsis 15 weight portion, Poria 15 weight portion, the Rhizoma Atractylodis Macrocephalae (stir-fry) 8.5 weight portion, the Radix Aucklandiae 8 weight portion, Fructus Amomi 6 weight portion, Rhizoma Corydalis
(vinegar system) 12 weight portion, Radix Glycyrrhizae Preparata 10 weight portion
The preparation method of oral liquid, step is as follows：
Step 1, above 11 herbal medicines, plus 95% alcohol reflux of 10 times amount, extracting solution, filtration, reclaim ethanol extremely
No alcohol taste；
Step 2, adds surfactant, LaspartylLphenylalanine methylester, Preservative qs；
Step 3, the product mixing of step 1-2, it is adjusted to total amount 1000ml, cold preservation, filtration, filtrate fill with distilled water, go out
Bacterium obtains final product.
Claims (6)
1. a kind of Orally administered composition for treating child's weakness of the spleen and stomach, eating accumulation, anorexia, inappetence, diet minimizing, institute
State compositionss, be prepared from by the raw material of Chinese medicine medicine of following weight proportion：
Fructus Crataegi (parching to brown) 10-18 weight portion, Massa Medicata Fermentata (parching to brown) 10-18 weight portion, Fructus Hordei Germinatus (parching to brown) 12-20 weight portion, the Radix Paeoniae Alba
20-28 weight portion, Radix Codonopsis 12-18 weight portion, Poria 8-18 weight portion, the Rhizoma Atractylodis Macrocephalae (stir-fry) 6-10 weight portion, Radix Aucklandiae 6-12 weight portion,
Fructus Amomi 2-8 weight portion, Rhizoma Corydalis (vinegar system) 10-18 weight portion, Radix Glycyrrhizae Preparata 8-15 weight portion.
2. compositionss according to claim 1, are prepared from by the raw material of Chinese medicine medicine of following weight proportion：
Fructus Crataegi (parching to brown) 15 weight portion, Massa Medicata Fermentata (parching to brown) 15 weight portion, Fructus Hordei Germinatus (parching to brown) 15 weight portion, the Radix Paeoniae Alba 25 weight portion,
Radix Codonopsis 15 weight portion, Poria 15 weight portion, the Rhizoma Atractylodis Macrocephalae (stir-fry) 8.5 weight portion, the Radix Aucklandiae 8 weight portion, Fructus Amomi 6 weight portion, Rhizoma Corydalis (vinegar
System) 12 weight portions, Radix Glycyrrhizae Preparata 10 weight portion.
3. compositionss according to claim 1, described Orally administered composition, selected from tablet, capsule, granule, oral liquid,
Drop pill, pill.
4. compositionss according to claim 1, described Orally administered composition, selected from oral liquid.
5. the preparation method of the compositionss described in claim 1, methods described step is as follows：
Step 1, Fructus Amomi, the Radix Aucklandiae, Rhizoma Atractylodis Macrocephalae water extraction simultaneously collects volatile oil；
Step 2, is collected the medicinal residues medicinal liquid after volatile oil and is jointly added water to cook 1-3 time with remaining medical material, and each 1-3 hour decocts
Liquid filters, and concentrates, obtains concentrated solution；
Step 3, concentrated solution adds ethanol makes alcohol content reach 40-80%, and 8-96 hour is placed in cold preservation, filters after precipitate with ethanol, and filtrate subtracts
Push back receipts ethanol to no alcohol taste；Obtain no alcohol liquid；
Step 4, no alcohol liquid add step 1 gained volatile oil, mix with pharmaceutically acceptable carrier, are prepared into oral formulations combination
Thing.
6. preparation method according to claim 1, step is as follows：
Step 1, Fructus Amomi, the Radix Aucklandiae, the Rhizoma Atractylodis Macrocephalae adds 8-40 times amount water, extracts and collects volatile oil；
Step 2, is collected the medicinal residues medicinal liquid after volatile oil and is jointly added water to cook 2-3 time with remaining medical material, add water 6-10 times every time, decoct
Boil time 1-3 hour, merge decoction liquor, filtration, concentrate；
Step 3, plus ethanol makes alcohol content reach 55-75%, cold preservation 10-48 hour, Precipitation, filtration, filtrate decompression reclaims
Ethanol, to no alcohol taste, obtains no alcohol liquid
Step 4, adds volatile oil and proper amount of surfactant, adds taurine 1-2g, LaspartylLphenylalanine methylester or
Appropriate sucralose, Preservative qs, are adjusted to total amount 1000ml, cold preservation, filtration, filtrate fill, sterilizing, thus obtaining the product with distilled water.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109730981A (en) * | 2019-03-07 | 2019-05-10 | 张春梅 | For treating anorexia, dyspeptic Traditional Chinese medicine composition patch, preparation and its application |
| CN112870309A (en) * | 2021-04-16 | 2021-06-01 | 扬子江药业集团江苏龙凤堂中药有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating or improving gastrointestinal diseases |
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|---|---|---|---|---|
| CN101708306A (en) * | 2009-12-10 | 2010-05-19 | 蚌埠丰原涂山制药有限公司 | Chinese medicinal composition for treating gastropathy and preparation method thereof |
| CN101829302A (en) * | 2010-05-13 | 2010-09-15 | 四川大学华西医院 | Chinese herbal compound preparation for improving radiotherapy and chemotherapy digestive tract reaction |
| CN105362906A (en) * | 2015-11-29 | 2016-03-02 | 王宁 | Traditional Chinese medicine for treating spleen-stomach deficiency and food stagnation symptoms of children and method for preparing traditional Chinese medicine |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101708306A (en) * | 2009-12-10 | 2010-05-19 | 蚌埠丰原涂山制药有限公司 | Chinese medicinal composition for treating gastropathy and preparation method thereof |
| CN101829302A (en) * | 2010-05-13 | 2010-09-15 | 四川大学华西医院 | Chinese herbal compound preparation for improving radiotherapy and chemotherapy digestive tract reaction |
| CN105362906A (en) * | 2015-11-29 | 2016-03-02 | 王宁 | Traditional Chinese medicine for treating spleen-stomach deficiency and food stagnation symptoms of children and method for preparing traditional Chinese medicine |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109730981A (en) * | 2019-03-07 | 2019-05-10 | 张春梅 | For treating anorexia, dyspeptic Traditional Chinese medicine composition patch, preparation and its application |
| CN112870309A (en) * | 2021-04-16 | 2021-06-01 | 扬子江药业集团江苏龙凤堂中药有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating or improving gastrointestinal diseases |
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