CN106459123A - 用于改善甜味的含有甜叶悬钩子苷或α‑葡糖基甜叶悬钩子苷的新型物质混合物 - Google Patents
用于改善甜味的含有甜叶悬钩子苷或α‑葡糖基甜叶悬钩子苷的新型物质混合物 Download PDFInfo
- Publication number
- CN106459123A CN106459123A CN201580028334.2A CN201580028334A CN106459123A CN 106459123 A CN106459123 A CN 106459123A CN 201580028334 A CN201580028334 A CN 201580028334A CN 106459123 A CN106459123 A CN 106459123A
- Authority
- CN
- China
- Prior art keywords
- weight
- compound
- 4glc
- glc
- fructus rubi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 138
- 235000019605 sweet taste sensations Nutrition 0.000 title claims abstract description 32
- YWPVROCHNBYFTP-UHFFFAOYSA-N Rubusoside Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC1OC(CO)C(O)C(O)C1O YWPVROCHNBYFTP-UHFFFAOYSA-N 0.000 title description 2
- YWPVROCHNBYFTP-OSHKXICASA-N rubusoside Chemical compound O([C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YWPVROCHNBYFTP-OSHKXICASA-N 0.000 title description 2
- 230000002708 enhancing effect Effects 0.000 title 1
- 238000002360 preparation method Methods 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims description 105
- 229930182470 glycoside Natural products 0.000 claims description 101
- 150000002338 glycosides Chemical class 0.000 claims description 96
- -1 2,4 dihydro phenyl Chemical group 0.000 claims description 70
- 229930182478 glucoside Natural products 0.000 claims description 50
- 239000000126 substance Substances 0.000 claims description 49
- 150000008131 glucosides Chemical class 0.000 claims description 45
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 40
- 235000019640 taste Nutrition 0.000 claims description 39
- 150000001875 compounds Chemical class 0.000 claims description 38
- 239000000463 material Substances 0.000 claims description 33
- 238000009472 formulation Methods 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- 229920002472 Starch Polymers 0.000 claims description 27
- 239000008107 starch Substances 0.000 claims description 27
- 235000019698 starch Nutrition 0.000 claims description 27
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims description 26
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 20
- 238000000354 decomposition reaction Methods 0.000 claims description 19
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 17
- 229930195729 fatty acid Natural products 0.000 claims description 17
- 239000000194 fatty acid Substances 0.000 claims description 17
- 239000003205 fragrance Substances 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 15
- AIONOLUJZLIMTK-AWEZNQCLSA-N hesperetin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O)=CC(O)=C2C(=O)C1 AIONOLUJZLIMTK-AWEZNQCLSA-N 0.000 claims description 12
- FTODBIPDTXRIGS-UHFFFAOYSA-N homoeriodictyol Natural products C1=C(O)C(OC)=CC(C2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 FTODBIPDTXRIGS-UHFFFAOYSA-N 0.000 claims description 12
- VGEREEWJJVICBM-UHFFFAOYSA-N phloretin Chemical compound C1=CC(O)=CC=C1CCC(=O)C1=C(O)C=C(O)C=C1O VGEREEWJJVICBM-UHFFFAOYSA-N 0.000 claims description 12
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 claims description 11
- 239000000284 extract Substances 0.000 claims description 11
- AIONOLUJZLIMTK-UHFFFAOYSA-N hesperetin Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(O)=CC(O)=C2C(=O)C1 AIONOLUJZLIMTK-UHFFFAOYSA-N 0.000 claims description 11
- 235000010209 hesperetin Nutrition 0.000 claims description 11
- 229960001587 hesperetin Drugs 0.000 claims description 11
- 235000006092 Stevia rebaudiana Nutrition 0.000 claims description 9
- 150000004665 fatty acids Chemical class 0.000 claims description 9
- 150000002576 ketones Chemical class 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 9
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 150000001720 carbohydrates Chemical class 0.000 claims description 8
- 150000002989 phenols Chemical class 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 7
- 230000013595 glycosylation Effects 0.000 claims description 7
- 238000006206 glycosylation reaction Methods 0.000 claims description 7
- ZWTDXYUDJYDHJR-UHFFFAOYSA-N (E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)-2-propen-1-one Natural products OC1=CC(O)=CC=C1C=CC(=O)C1=CC=C(O)C=C1O ZWTDXYUDJYDHJR-UHFFFAOYSA-N 0.000 claims description 6
- YQHMWTPYORBCMF-UHFFFAOYSA-N Naringenin chalcone Natural products C1=CC(O)=CC=C1C=CC(=O)C1=C(O)C=C(O)C=C1O YQHMWTPYORBCMF-UHFFFAOYSA-N 0.000 claims description 6
- 239000000758 substrate Substances 0.000 claims description 6
- 235000014633 carbohydrates Nutrition 0.000 claims description 5
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims description 4
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims description 3
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims description 3
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims description 3
- 229940125904 compound 1 Drugs 0.000 claims description 3
- SZUVGFMDDVSKSI-WIFOCOSTSA-N (1s,2s,3s,5r)-1-(carboxymethyl)-3,5-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclopentane-1,2-dicarboxylic acid Chemical compound O=C([C@@H]1[C@@H]([C@](CC(O)=O)([C@H](C(=O)N(CCC)CC=2C=CC(OC=3C=CC=CC=3)=CC=2)C1)C(O)=O)C(O)=O)N(CCC)CC(C=C1)=CC=C1OC1=CC=CC=C1 SZUVGFMDDVSKSI-WIFOCOSTSA-N 0.000 claims description 2
- GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical compound C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 claims description 2
- QFLWZFQWSBQYPS-AWRAUJHKSA-N (3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acid Chemical compound CCCC(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(C)C)P(=O)(Oc1ccc(Cl)cc1)Oc1ccc(Cl)cc1 QFLWZFQWSBQYPS-AWRAUJHKSA-N 0.000 claims description 2
- UNILWMWFPHPYOR-KXEYIPSPSA-M 1-[6-[2-[3-[3-[3-[2-[2-[3-[[2-[2-[[(2r)-1-[[2-[[(2r)-1-[3-[2-[2-[3-[[2-(2-amino-2-oxoethoxy)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-[(2r)-2,3-di(hexadecanoyloxy)propyl]sulfanyl-1-oxopropan-2-yl Chemical compound O=C1C(SCCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NCC(=O)N[C@H](CO)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O)CC(=O)N1CCNC(=O)CCCCCN\1C2=CC=C(S([O-])(=O)=O)C=C2CC/1=C/C=C/C=C/C1=[N+](CC)C2=CC=C(S([O-])(=O)=O)C=C2C1 UNILWMWFPHPYOR-KXEYIPSPSA-M 0.000 claims description 2
- 229940125773 compound 10 Drugs 0.000 claims description 2
- 229940125797 compound 12 Drugs 0.000 claims description 2
- 229940126543 compound 14 Drugs 0.000 claims description 2
- 229940125758 compound 15 Drugs 0.000 claims description 2
- 229940125782 compound 2 Drugs 0.000 claims description 2
- 229940126214 compound 3 Drugs 0.000 claims description 2
- 229940125898 compound 5 Drugs 0.000 claims description 2
- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 claims description 2
- GLGNXYJARSMNGJ-VKTIVEEGSA-N (1s,2s,3r,4r)-3-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3h-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Chemical compound CCN1C(=O)CCCC2=C(OC)C(NC=3N=C(C(=CN=3)Cl)N[C@H]3[C@H]([C@@]4([H])C[C@@]3(C=C4)[H])C(N)=O)=CC=C21 GLGNXYJARSMNGJ-VKTIVEEGSA-N 0.000 claims 1
- 241000543392 Symplocos Species 0.000 claims 1
- 150000004880 oxines Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 abstract description 3
- 239000000047 product Substances 0.000 description 45
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 19
- 239000003921 oil Substances 0.000 description 18
- 235000019198 oils Nutrition 0.000 description 18
- 235000009508 confectionery Nutrition 0.000 description 16
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 15
- 235000013305 food Nutrition 0.000 description 15
- 239000000796 flavoring agent Substances 0.000 description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 14
- 241000196324 Embryophyta Species 0.000 description 13
- 235000013399 edible fruits Nutrition 0.000 description 13
- 235000000346 sugar Nutrition 0.000 description 13
- 229940112822 chewing gum Drugs 0.000 description 12
- 235000015218 chewing gum Nutrition 0.000 description 12
- 235000019634 flavors Nutrition 0.000 description 12
- 150000001299 aldehydes Chemical class 0.000 description 11
- 150000002148 esters Chemical class 0.000 description 11
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 10
- 239000002253 acid Substances 0.000 description 10
- 235000013361 beverage Nutrition 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 9
- 239000002562 thickening agent Substances 0.000 description 9
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 8
- 244000228451 Stevia rebaudiana Species 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- OBNCKNCVKJNDBV-UHFFFAOYSA-N ethyl butyrate Chemical compound CCCC(=O)OCC OBNCKNCVKJNDBV-UHFFFAOYSA-N 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- 210000000214 mouth Anatomy 0.000 description 8
- 235000013599 spices Nutrition 0.000 description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
- 241001092459 Rubus Species 0.000 description 7
- 239000000654 additive Substances 0.000 description 7
- 229940088598 enzyme Drugs 0.000 description 7
- 239000003292 glue Substances 0.000 description 7
- 235000019202 steviosides Nutrition 0.000 description 7
- 239000004375 Dextrin Substances 0.000 description 6
- 229920001353 Dextrin Polymers 0.000 description 6
- 241000628997 Flos Species 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- QUKGYYKBILRGFE-UHFFFAOYSA-N benzyl acetate Chemical compound CC(=O)OCC1=CC=CC=C1 QUKGYYKBILRGFE-UHFFFAOYSA-N 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 6
- 235000019425 dextrin Nutrition 0.000 description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 6
- SATCULPHIDQDRE-UHFFFAOYSA-N piperonal Chemical compound O=CC1=CC=C2OCOC2=C1 SATCULPHIDQDRE-UHFFFAOYSA-N 0.000 description 6
- 235000018102 proteins Nutrition 0.000 description 6
- 150000005846 sugar alcohols Chemical class 0.000 description 6
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 6
- 239000000606 toothpaste Substances 0.000 description 6
- 229940034610 toothpaste Drugs 0.000 description 6
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 5
- 229920002774 Maltodextrin Polymers 0.000 description 5
- 244000299461 Theobroma cacao Species 0.000 description 5
- 230000000996 additive effect Effects 0.000 description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 239000000975 dye Substances 0.000 description 5
- 239000003995 emulsifying agent Substances 0.000 description 5
- 239000000945 filler Substances 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 235000013336 milk Nutrition 0.000 description 5
- 239000008267 milk Substances 0.000 description 5
- 210000004080 milk Anatomy 0.000 description 5
- 239000002304 perfume Substances 0.000 description 5
- 210000000582 semen Anatomy 0.000 description 5
- 235000002639 sodium chloride Nutrition 0.000 description 5
- 235000020357 syrup Nutrition 0.000 description 5
- 239000006188 syrup Substances 0.000 description 5
- 239000002023 wood Substances 0.000 description 5
- YGWKXXYGDYYFJU-SSDOTTSWSA-N (+)-menthofuran Chemical compound C1[C@H](C)CCC2=C1OC=C2C YGWKXXYGDYYFJU-SSDOTTSWSA-N 0.000 description 4
- 239000001745 (6R)-3,6-dimethyl-4,5,6,7-tetrahydro-1-benzofuran Substances 0.000 description 4
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 4
- RXGUIWHIADMCFC-UHFFFAOYSA-N 2-Methylpropyl 2-methylpropionate Chemical compound CC(C)COC(=O)C(C)C RXGUIWHIADMCFC-UHFFFAOYSA-N 0.000 description 4
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 4
- 229930091371 Fructose Natural products 0.000 description 4
- 239000005715 Fructose Substances 0.000 description 4
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 4
- 239000005913 Maltodextrin Substances 0.000 description 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 4
- YGWKXXYGDYYFJU-UHFFFAOYSA-N Menthofuran Natural products C1C(C)CCC2=C1OC=C2C YGWKXXYGDYYFJU-UHFFFAOYSA-N 0.000 description 4
- 241001597008 Nomeidae Species 0.000 description 4
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 4
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 4
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 4
- 235000019219 chocolate Nutrition 0.000 description 4
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- UDGKKUWYNITJRX-UHFFFAOYSA-N davidigenin Chemical compound C1=CC(O)=CC=C1CCC(=O)C1=CC=C(O)C=C1O UDGKKUWYNITJRX-UHFFFAOYSA-N 0.000 description 4
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 4
- 239000003925 fat Substances 0.000 description 4
- IFYYFLINQYPWGJ-UHFFFAOYSA-N gamma-decalactone Chemical compound CCCCCCC1CCC(=O)O1 IFYYFLINQYPWGJ-UHFFFAOYSA-N 0.000 description 4
- UWKAYLJWKGQEPM-LBPRGKRZSA-N linalyl acetate Chemical compound CC(C)=CCC[C@](C)(C=C)OC(C)=O UWKAYLJWKGQEPM-LBPRGKRZSA-N 0.000 description 4
- 229940035034 maltodextrin Drugs 0.000 description 4
- KVWWIYGFBYDJQC-UHFFFAOYSA-N methyl dihydrojasmonate Chemical compound CCCCCC1C(CC(=O)OC)CCC1=O KVWWIYGFBYDJQC-UHFFFAOYSA-N 0.000 description 4
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 4
- 229920003052 natural elastomer Polymers 0.000 description 4
- 229920001194 natural rubber Polymers 0.000 description 4
- 239000004014 plasticizer Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 4
- 235000012239 silicon dioxide Nutrition 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- 235000010356 sorbitol Nutrition 0.000 description 4
- 229940013618 stevioside Drugs 0.000 description 4
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- 235000013311 vegetables Nutrition 0.000 description 4
- PHXATPHONSXBIL-UHFFFAOYSA-N xi-gamma-Undecalactone Chemical compound CCCCCCCC1CCC(=O)O1 PHXATPHONSXBIL-UHFFFAOYSA-N 0.000 description 4
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 3
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 3
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 3
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 3
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 3
- 239000005792 Geraniol Substances 0.000 description 3
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 3
- 239000004378 Glycyrrhizin Substances 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- MZSGWZGPESCJAN-MOBFUUNNSA-N Melitric acid A Natural products O([C@@H](C(=O)O)Cc1cc(O)c(O)cc1)C(=O)/C=C/c1cc(O)c(O/C(/C(=O)O)=C/c2cc(O)c(O)cc2)cc1 MZSGWZGPESCJAN-MOBFUUNNSA-N 0.000 description 3
- 108050004114 Monellin Proteins 0.000 description 3
- 235000017284 Pometia pinnata Nutrition 0.000 description 3
- 240000007653 Pometia tomentosa Species 0.000 description 3
- 239000004383 Steviol glycoside Substances 0.000 description 3
- 239000004376 Sucralose Substances 0.000 description 3
- 239000005844 Thymol Substances 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 3
- 229940007550 benzyl acetate Drugs 0.000 description 3
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 3
- 235000019658 bitter taste Nutrition 0.000 description 3
- RHDGNLCLDBVESU-UHFFFAOYSA-N but-3-en-4-olide Chemical compound O=C1CC=CO1 RHDGNLCLDBVESU-UHFFFAOYSA-N 0.000 description 3
- 235000013736 caramel Nutrition 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 235000000484 citronellol Nutrition 0.000 description 3
- 238000012937 correction Methods 0.000 description 3
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 3
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 229930004069 diterpene Natural products 0.000 description 3
- 235000013601 eggs Nutrition 0.000 description 3
- 229920001971 elastomer Polymers 0.000 description 3
- SBHXYTNGIZCORC-ZDUSSCGKSA-N eriodictyol Chemical compound C1([C@@H]2CC(=O)C3=C(O)C=C(C=C3O2)O)=CC=C(O)C(O)=C1 SBHXYTNGIZCORC-ZDUSSCGKSA-N 0.000 description 3
- TUJPOVKMHCLXEL-UHFFFAOYSA-N eriodictyol Natural products C1C(=O)C2=CC(O)=CC(O)=C2OC1C1=CC=C(O)C(O)=C1 TUJPOVKMHCLXEL-UHFFFAOYSA-N 0.000 description 3
- 235000011797 eriodictyol Nutrition 0.000 description 3
- SBHXYTNGIZCORC-UHFFFAOYSA-N eriodyctiol Natural products O1C2=CC(O)=CC(O)=C2C(=O)CC1C1=CC=C(O)C(O)=C1 SBHXYTNGIZCORC-UHFFFAOYSA-N 0.000 description 3
- 125000004494 ethyl ester group Chemical group 0.000 description 3
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 3
- CBOQJANXLMLOSS-UHFFFAOYSA-N ethyl vanillin Chemical compound CCOC1=CC(C=O)=CC=C1O CBOQJANXLMLOSS-UHFFFAOYSA-N 0.000 description 3
- 239000010642 eucalyptus oil Substances 0.000 description 3
- 229940044949 eucalyptus oil Drugs 0.000 description 3
- 235000019197 fats Nutrition 0.000 description 3
- QOLIPNRNLBQTAU-UHFFFAOYSA-N flavan Chemical compound C1CC2=CC=CC=C2OC1C1=CC=CC=C1 QOLIPNRNLBQTAU-UHFFFAOYSA-N 0.000 description 3
- 235000007983 food acid Nutrition 0.000 description 3
- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 description 3
- 229940113087 geraniol Drugs 0.000 description 3
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 3
- 229960004949 glycyrrhizic acid Drugs 0.000 description 3
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 3
- 235000019410 glycyrrhizin Nutrition 0.000 description 3
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 3
- 229920000591 gum Polymers 0.000 description 3
- 239000000413 hydrolysate Substances 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 3
- 229930007744 linalool Natural products 0.000 description 3
- 239000001630 malic acid Substances 0.000 description 3
- 235000011090 malic acid Nutrition 0.000 description 3
- 230000000873 masking effect Effects 0.000 description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 3
- JYVLIDXNZAXMDK-UHFFFAOYSA-N pentan-2-ol Chemical compound CCCC(C)O JYVLIDXNZAXMDK-UHFFFAOYSA-N 0.000 description 3
- 229940081310 piperonal Drugs 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 235000015067 sauces Nutrition 0.000 description 3
- 235000014214 soft drink Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 235000019411 steviol glycoside Nutrition 0.000 description 3
- 229930182488 steviol glycoside Natural products 0.000 description 3
- 150000008144 steviol glycosides Chemical class 0.000 description 3
- 235000019408 sucralose Nutrition 0.000 description 3
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 3
- 229960000790 thymol Drugs 0.000 description 3
- 239000004408 titanium dioxide Substances 0.000 description 3
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 3
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 3
- 235000012141 vanillin Nutrition 0.000 description 3
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 2
- GRWFGVWFFZKLTI-IUCAKERBSA-N (-)-α-pinene Chemical compound CC1=CC[C@@H]2C(C)(C)[C@H]1C2 GRWFGVWFFZKLTI-IUCAKERBSA-N 0.000 description 2
- YSCJAYPKBYRXEZ-HZPINHDXSA-N (2s,3s,4s,5r,6r)-6-[[(3s,4ar,6ar,6bs,8as,12as,14ar,14br)-4,4,6a,6b,11,11,14b-heptamethyl-8a-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3-hydroxy-4-[(2s,3r,4s, Chemical compound O([C@H]1[C@H](O)[C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2C1(C)C)C)(C)CC[C@]1(CCC(C[C@H]14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C(O)=O)[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O YSCJAYPKBYRXEZ-HZPINHDXSA-N 0.000 description 2
- NUFKRGBSZPCGQB-FLBSXDLDSA-N (3s)-3-amino-4-oxo-4-[[(2r)-1-oxo-1-[(2,2,4,4-tetramethylthietan-3-yl)amino]propan-2-yl]amino]butanoic acid;pentahydrate Chemical compound O.O.O.O.O.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C NUFKRGBSZPCGQB-FLBSXDLDSA-N 0.000 description 2
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 2
- OOCCDEMITAIZTP-QPJJXVBHSA-N (E)-cinnamyl alcohol Chemical compound OC\C=C\C1=CC=CC=C1 OOCCDEMITAIZTP-QPJJXVBHSA-N 0.000 description 2
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 2
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 2
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- GFAZHVHNLUBROE-UHFFFAOYSA-N 1-hydroxybutan-2-one Chemical class CCC(=O)CO GFAZHVHNLUBROE-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- GLCOTRLUPUIAFI-UHFFFAOYSA-N 2,3-dimethyl-2h-furan-5-one Chemical compound CC1OC(=O)C=C1C GLCOTRLUPUIAFI-UHFFFAOYSA-N 0.000 description 2
- HJFZAYHYIWGLNL-UHFFFAOYSA-N 2,6-Dimethylpyrazine Chemical compound CC1=CN=CC(C)=N1 HJFZAYHYIWGLNL-UHFFFAOYSA-N 0.000 description 2
- MOMFXATYAINJML-UHFFFAOYSA-N 2-Acetylthiazole Chemical group CC(=O)C1=NC=CS1 MOMFXATYAINJML-UHFFFAOYSA-N 0.000 description 2
- FLUWAIIVLCVEKF-UHFFFAOYSA-N 2-Methyl-1-phenyl-2-propanyl acetate Chemical compound CC(=O)OC(C)(C)CC1=CC=CC=C1 FLUWAIIVLCVEKF-UHFFFAOYSA-N 0.000 description 2
- RYVVJXGADODIJD-UHFFFAOYSA-N 2-hydroxyfuran-3-one Chemical compound OC1OC=CC1=O RYVVJXGADODIJD-UHFFFAOYSA-N 0.000 description 2
- HCFAJYNVAYBARA-UHFFFAOYSA-N 4-heptanone Chemical compound CCCC(=O)CCC HCFAJYNVAYBARA-UHFFFAOYSA-N 0.000 description 2
- OALYTRUKMRCXNH-UHFFFAOYSA-N 5-pentyloxolan-2-one Chemical compound CCCCCC1CCC(=O)O1 OALYTRUKMRCXNH-UHFFFAOYSA-N 0.000 description 2
- GHBSPIPJMLAMEP-UHFFFAOYSA-N 6-pentyloxan-2-one Chemical compound CCCCCC1CCCC(=O)O1 GHBSPIPJMLAMEP-UHFFFAOYSA-N 0.000 description 2
- 241000208140 Acer Species 0.000 description 2
- ROWKJAVDOGWPAT-UHFFFAOYSA-N Acetoin Chemical compound CC(O)C(C)=O ROWKJAVDOGWPAT-UHFFFAOYSA-N 0.000 description 2
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 240000004246 Agave americana Species 0.000 description 2
- 239000004377 Alitame Substances 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- 108010011485 Aspartame Proteins 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- ZCTQGTTXIYCGGC-UHFFFAOYSA-N Benzyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OCC1=CC=CC=C1 ZCTQGTTXIYCGGC-UHFFFAOYSA-N 0.000 description 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N Benzylformate Chemical compound O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 2
- 241000717739 Boswellia sacra Species 0.000 description 2
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 2
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 2
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 2
- 108010025880 Cyclomaltodextrin glucanotransferase Proteins 0.000 description 2
- BZKFMUIJRXWWQK-UHFFFAOYSA-N Cyclopentenone Chemical compound O=C1CCC=C1 BZKFMUIJRXWWQK-UHFFFAOYSA-N 0.000 description 2
- 240000004784 Cymbopogon citratus Species 0.000 description 2
- 235000017897 Cymbopogon citratus Nutrition 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 208000006558 Dental Calculus Diseases 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- NIQCNGHVCWTJSM-UHFFFAOYSA-N Dimethyl phthalate Chemical compound COC(=O)C1=CC=CC=C1C(=O)OC NIQCNGHVCWTJSM-UHFFFAOYSA-N 0.000 description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 2
- 239000005770 Eugenol Substances 0.000 description 2
- 239000001329 FEMA 3811 Substances 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 239000004863 Frankincense Substances 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 108010031186 Glycoside Hydrolases Proteins 0.000 description 2
- 102000005744 Glycoside Hydrolases Human genes 0.000 description 2
- 229920002907 Guar gum Polymers 0.000 description 2
- 239000000899 Gutta-Percha Substances 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 description 2
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 2
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 2
- BTJXBZZBBNNTOV-UHFFFAOYSA-N Linalyl benzoate Chemical compound CC(C)=CCCC(C)(C=C)OC(=O)C1=CC=CC=C1 BTJXBZZBBNNTOV-UHFFFAOYSA-N 0.000 description 2
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- UUQHKWMIDYRWHH-UHFFFAOYSA-N Methyl beta-orcinolcarboxylate Chemical group COC(=O)C1=C(C)C=C(O)C(C)=C1O UUQHKWMIDYRWHH-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 2
- 240000000342 Palaquium gutta Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 2
- NBBJYMSMWIIQGU-UHFFFAOYSA-N Propionic aldehyde Chemical compound CCC=O NBBJYMSMWIIQGU-UHFFFAOYSA-N 0.000 description 2
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 2
- 108010073771 Soybean Proteins Proteins 0.000 description 2
- 235000015125 Sterculia urens Nutrition 0.000 description 2
- 240000001058 Sterculia urens Species 0.000 description 2
- QFVOYBUQQBFCRH-UHFFFAOYSA-N Steviol Natural products C1CC2(C3)CC(=C)C3(O)CCC2C2(C)C1C(C)(C(O)=O)CCC2 QFVOYBUQQBFCRH-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- MOYAFQVGZZPNRA-UHFFFAOYSA-N Terpinolene Chemical compound CC(C)=C1CCC(C)=CC1 MOYAFQVGZZPNRA-UHFFFAOYSA-N 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000001361 adipic acid Substances 0.000 description 2
- 235000011037 adipic acid Nutrition 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 235000010419 agar Nutrition 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 239000000783 alginic acid Substances 0.000 description 2
- 229960001126 alginic acid Drugs 0.000 description 2
- 150000004781 alginic acids Chemical class 0.000 description 2
- 235000019409 alitame Nutrition 0.000 description 2
- 108010009985 alitame Proteins 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-UHFFFAOYSA-N alpha-D-glucopyranose Natural products OCC1OC(O)C(O)C(O)C1O WQZGKKKJIJFFOK-UHFFFAOYSA-N 0.000 description 2
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- PZZYQPZGQPZBDN-UHFFFAOYSA-N aluminium silicate Chemical compound O=[Al]O[Si](=O)O[Al]=O PZZYQPZGQPZBDN-UHFFFAOYSA-N 0.000 description 2
- 229910000323 aluminium silicate Inorganic materials 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 239000010692 aromatic oil Substances 0.000 description 2
- 239000000605 aspartame Substances 0.000 description 2
- 235000010357 aspartame Nutrition 0.000 description 2
- 229960003438 aspartame Drugs 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 235000013405 beer Nutrition 0.000 description 2
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 description 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
- AKGGYBADQZYZPD-UHFFFAOYSA-N benzylacetone Chemical compound CC(=O)CCC1=CC=CC=C1 AKGGYBADQZYZPD-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 235000008429 bread Nutrition 0.000 description 2
- 235000015155 buttermilk Nutrition 0.000 description 2
- XUPYJHCZDLZNFP-UHFFFAOYSA-N butyl butanoate Chemical compound CCCCOC(=O)CCC XUPYJHCZDLZNFP-UHFFFAOYSA-N 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- CRPUJAZIXJMDBK-UHFFFAOYSA-N camphene Chemical compound C1CC2C(=C)C(C)(C)C1C2 CRPUJAZIXJMDBK-UHFFFAOYSA-N 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 235000013877 carbamide Nutrition 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 235000013351 cheese Nutrition 0.000 description 2
- 229960005233 cineole Drugs 0.000 description 2
- 229940117916 cinnamic aldehyde Drugs 0.000 description 2
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 2
- 229940043350 citral Drugs 0.000 description 2
- 229930003633 citronellal Natural products 0.000 description 2
- 235000000983 citronellal Nutrition 0.000 description 2
- JOZKFWLRHCDGJA-UHFFFAOYSA-N citronellol acetate Chemical compound CC(=O)OCCC(C)CCC=C(C)C JOZKFWLRHCDGJA-UHFFFAOYSA-N 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
- 229940019836 cyclamen aldehyde Drugs 0.000 description 2
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 2
- 239000000551 dentifrice Substances 0.000 description 2
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 2
- PXLWOFBAEVGBOA-UHFFFAOYSA-N dihydrochalcone Natural products OC1C(O)C(O)C(CO)OC1C1=C(O)C=CC(C(=O)CC(O)C=2C=CC(O)=CC=2)=C1O PXLWOFBAEVGBOA-UHFFFAOYSA-N 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 229940095104 dimethyl benzyl carbinyl acetate Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 150000002118 epoxides Chemical class 0.000 description 2
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 description 2
- RGXWDWUGBIJHDO-UHFFFAOYSA-N ethyl decanoate Chemical compound CCCCCCCCCC(=O)OCC RGXWDWUGBIJHDO-UHFFFAOYSA-N 0.000 description 2
- PPXUHEORWJQRHJ-UHFFFAOYSA-N ethyl isovalerate Chemical compound CCOC(=O)CC(C)C PPXUHEORWJQRHJ-UHFFFAOYSA-N 0.000 description 2
- YYZUSRORWSJGET-UHFFFAOYSA-N ethyl octanoate Chemical compound CCCCCCCC(=O)OCC YYZUSRORWSJGET-UHFFFAOYSA-N 0.000 description 2
- FKRCODPIKNYEAC-UHFFFAOYSA-N ethyl propionate Chemical compound CCOC(=O)CC FKRCODPIKNYEAC-UHFFFAOYSA-N 0.000 description 2
- 229940073505 ethyl vanillin Drugs 0.000 description 2
- 229960002217 eugenol Drugs 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 235000013373 food additive Nutrition 0.000 description 2
- 239000002778 food additive Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 239000001530 fumaric acid Substances 0.000 description 2
- 229930182830 galactose Natural products 0.000 description 2
- IFYYFLINQYPWGJ-VIFPVBQESA-N gamma-Decalactone Natural products CCCCCC[C@H]1CCC(=O)O1 IFYYFLINQYPWGJ-VIFPVBQESA-N 0.000 description 2
- PHXATPHONSXBIL-JTQLQIEISA-N gamma-Undecalactone Natural products CCCCCCC[C@H]1CCC(=O)O1 PHXATPHONSXBIL-JTQLQIEISA-N 0.000 description 2
- 125000000457 gamma-lactone group Chemical group 0.000 description 2
- 229940020436 gamma-undecalactone Drugs 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 2
- HIGQPQRQIQDZMP-UHFFFAOYSA-N geranil acetate Natural products CC(C)=CCCC(C)=CCOC(C)=O HIGQPQRQIQDZMP-UHFFFAOYSA-N 0.000 description 2
- HIGQPQRQIQDZMP-DHZHZOJOSA-N geranyl acetate Chemical compound CC(C)=CCC\C(C)=C\COC(C)=O HIGQPQRQIQDZMP-DHZHZOJOSA-N 0.000 description 2
- 239000000174 gluconic acid Substances 0.000 description 2
- 235000012208 gluconic acid Nutrition 0.000 description 2
- 150000002337 glycosamines Chemical class 0.000 description 2
- 125000003147 glycosyl group Chemical group 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 2
- BPMFZUMJYQTVII-UHFFFAOYSA-N guanidinoacetic acid Chemical compound NC(=N)NCC(O)=O BPMFZUMJYQTVII-UHFFFAOYSA-N 0.000 description 2
- 235000010417 guar gum Nutrition 0.000 description 2
- 239000000665 guar gum Substances 0.000 description 2
- 229960002154 guar gum Drugs 0.000 description 2
- 229920000588 gutta-percha Polymers 0.000 description 2
- CATSNJVOTSVZJV-UHFFFAOYSA-N heptan-2-one Chemical compound CCCCCC(C)=O CATSNJVOTSVZJV-UHFFFAOYSA-N 0.000 description 2
- NGAZZOYFWWSOGK-UHFFFAOYSA-N heptan-3-one Chemical compound CCCCC(=O)CC NGAZZOYFWWSOGK-UHFFFAOYSA-N 0.000 description 2
- FTODBIPDTXRIGS-ZDUSSCGKSA-N homoeriodictyol Chemical compound C1=C(O)C(OC)=CC([C@H]2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 FTODBIPDTXRIGS-ZDUSSCGKSA-N 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- MLFHJEHSLIIPHL-UHFFFAOYSA-N isoamyl acetate Chemical compound CC(C)CCOC(C)=O MLFHJEHSLIIPHL-UHFFFAOYSA-N 0.000 description 2
- PQLMXFQTAMDXIZ-UHFFFAOYSA-N isoamyl butyrate Chemical compound CCCC(=O)OCCC(C)C PQLMXFQTAMDXIZ-UHFFFAOYSA-N 0.000 description 2
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 2
- ZYTMANIQRDEHIO-KXUCPTDWSA-N isopulegol Chemical compound C[C@@H]1CC[C@@H](C(C)=C)[C@H](O)C1 ZYTMANIQRDEHIO-KXUCPTDWSA-N 0.000 description 2
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 2
- 150000002596 lactones Chemical class 0.000 description 2
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- SDQFDHOLCGWZPU-UHFFFAOYSA-N lilial Chemical compound O=CC(C)CC1=CC=C(C(C)(C)C)C=C1 SDQFDHOLCGWZPU-UHFFFAOYSA-N 0.000 description 2
- UWKAYLJWKGQEPM-UHFFFAOYSA-N linalool acetate Natural products CC(C)=CCCC(C)(C=C)OC(C)=O UWKAYLJWKGQEPM-UHFFFAOYSA-N 0.000 description 2
- 235000004213 low-fat Nutrition 0.000 description 2
- 229940043353 maltol Drugs 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- NEDIAPMWNCQWNW-UHFFFAOYSA-N massoia lactone Chemical compound CCCCCC1CC=CC(=O)O1 NEDIAPMWNCQWNW-UHFFFAOYSA-N 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- VAMXMNNIEUEQDV-UHFFFAOYSA-N methyl anthranilate Chemical compound COC(=O)C1=CC=CC=C1N VAMXMNNIEUEQDV-UHFFFAOYSA-N 0.000 description 2
- 150000004702 methyl esters Chemical class 0.000 description 2
- NUKZAGXMHTUAFE-UHFFFAOYSA-N methyl hexanoate Chemical compound CCCCCC(=O)OC NUKZAGXMHTUAFE-UHFFFAOYSA-N 0.000 description 2
- ZGEGCLOFRBLKSE-UHFFFAOYSA-N methylene hexane Natural products CCCCCC=C ZGEGCLOFRBLKSE-UHFFFAOYSA-N 0.000 description 2
- 235000013379 molasses Nutrition 0.000 description 2
- ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 description 2
- 229940089953 neohesperidin dihydrochalcone Drugs 0.000 description 2
- 235000010434 neohesperidine DC Nutrition 0.000 description 2
- 235000019520 non-alcoholic beverage Nutrition 0.000 description 2
- VWMVAQHMFFZQGD-UHFFFAOYSA-N p-Hydroxybenzyl acetone Natural products CC(=O)CC1=CC=C(O)C=C1 VWMVAQHMFFZQGD-UHFFFAOYSA-N 0.000 description 2
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 description 2
- ZRSNZINYAWTAHE-UHFFFAOYSA-N p-methoxybenzaldehyde Chemical compound COC1=CC=C(C=O)C=C1 ZRSNZINYAWTAHE-UHFFFAOYSA-N 0.000 description 2
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000001814 pectin Substances 0.000 description 2
- XNLICIUVMPYHGG-UHFFFAOYSA-N pentan-2-one Chemical compound CCCC(C)=O XNLICIUVMPYHGG-UHFFFAOYSA-N 0.000 description 2
- MDHYEMXUFSJLGV-UHFFFAOYSA-N phenethyl acetate Chemical compound CC(=O)OCCC1=CC=CC=C1 MDHYEMXUFSJLGV-UHFFFAOYSA-N 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- ZQBAKBUEJOMQEX-UHFFFAOYSA-N phenyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OC1=CC=CC=C1 ZQBAKBUEJOMQEX-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- NJGBTKGETPDVIK-UHFFFAOYSA-N raspberry ketone Chemical compound CC(=O)CCC1=CC=C(O)C=C1 NJGBTKGETPDVIK-UHFFFAOYSA-N 0.000 description 2
- 229930188195 rebaudioside Natural products 0.000 description 2
- QSRAJVGDWKFOGU-WBXIDTKBSA-N rebaudioside c Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]1(CC[C@H]2[C@@]3(C)[C@@H]([C@](CCC3)(C)C(=O)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)CC3)C(=C)C[C@]23C1 QSRAJVGDWKFOGU-WBXIDTKBSA-N 0.000 description 2
- 235000020095 red wine Nutrition 0.000 description 2
- CZCBTSFUTPZVKJ-UHFFFAOYSA-N rose oxide Chemical compound CC1CCOC(C=C(C)C)C1 CZCBTSFUTPZVKJ-UHFFFAOYSA-N 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- 239000010670 sage oil Substances 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 235000013580 sausages Nutrition 0.000 description 2
- 235000011888 snacks Nutrition 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 229940083542 sodium Drugs 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- 235000011083 sodium citrates Nutrition 0.000 description 2
- 229960001462 sodium cyclamate Drugs 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 235000019710 soybean protein Nutrition 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 229940032084 steviol Drugs 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 239000001117 sulphuric acid Substances 0.000 description 2
- 235000011149 sulphuric acid Nutrition 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000003764 sweet protein Substances 0.000 description 2
- 229920003051 synthetic elastomer Polymers 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- 235000013616 tea Nutrition 0.000 description 2
- 150000003505 terpenes Chemical class 0.000 description 2
- 235000007586 terpenes Nutrition 0.000 description 2
- 229940116411 terpineol Drugs 0.000 description 2
- 235000010436 thaumatin Nutrition 0.000 description 2
- 239000000892 thaumatin Substances 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- RSJKGSCJYJTIGS-UHFFFAOYSA-N undecane Chemical compound CCCCCCCCCCC RSJKGSCJYJTIGS-UHFFFAOYSA-N 0.000 description 2
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 2
- WXETUDXXEZHSCS-MAVITOTKSA-N vertofix coeur Chemical compound C[C@@H]1CC[C@@]2(C(/CC3)=C\C(C)=O)[C@@H]3C(C)(C)[C@@H]1C2 WXETUDXXEZHSCS-MAVITOTKSA-N 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 239000009637 wintergreen oil Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- ZFNVDHOSLNRHNN-UHFFFAOYSA-N xi-3-(4-Isopropylphenyl)-2-methylpropanal Chemical compound O=CC(C)CC1=CC=C(C(C)C)C=C1 ZFNVDHOSLNRHNN-UHFFFAOYSA-N 0.000 description 2
- 239000000811 xylitol Substances 0.000 description 2
- 235000010447 xylitol Nutrition 0.000 description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
- 229960002675 xylitol Drugs 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- MHXCIKYXNYCMHY-AUSJPIAWSA-N (+)-lariciresinol Chemical compound C1=C(O)C(OC)=CC(C[C@@H]2[C@@H]([C@H](OC2)C=2C=C(OC)C(O)=CC=2)CO)=C1 MHXCIKYXNYCMHY-AUSJPIAWSA-N 0.000 description 1
- WTOYNNBCKUYIKC-JMSVASOKSA-N (+)-nootkatone Chemical compound C1C[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)CC(=O)C=C21 WTOYNNBCKUYIKC-JMSVASOKSA-N 0.000 description 1
- NZGWDASTMWDZIW-MRVPVSSYSA-N (+)-pulegone Chemical compound C[C@@H]1CCC(=C(C)C)C(=O)C1 NZGWDASTMWDZIW-MRVPVSSYSA-N 0.000 description 1
- QEBNYNLSCGVZOH-NFAWXSAZSA-N (+)-valencene Chemical compound C1C[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)CCC=C21 QEBNYNLSCGVZOH-NFAWXSAZSA-N 0.000 description 1
- MATGKVZWFZHCLI-LSDHHAIUSA-N (-)-matairesinol Chemical compound C1=C(O)C(OC)=CC(C[C@@H]2[C@H](C(=O)OC2)CC=2C=C(OC)C(O)=CC=2)=C1 MATGKVZWFZHCLI-LSDHHAIUSA-N 0.000 description 1
- GEWDNTWNSAZUDX-WQMVXFAESA-N (-)-methyl jasmonate Chemical compound CC\C=C/C[C@@H]1[C@@H](CC(=O)OC)CCC1=O GEWDNTWNSAZUDX-WQMVXFAESA-N 0.000 description 1
- RMLYXMMBIZLGAQ-UHFFFAOYSA-N (-)-monatin Natural products C1=CC=C2C(CC(O)(CC(N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-UHFFFAOYSA-N 0.000 description 1
- 239000001871 (1R,2R,5S)-5-methyl-2-prop-1-en-2-ylcyclohexan-1-ol Substances 0.000 description 1
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- ZHWLEUGSDGROJS-UHFFFAOYSA-N (2-tert-butylcyclohexyl) ethyl carbonate Chemical compound CCOC(=O)OC1CCCCC1C(C)(C)C ZHWLEUGSDGROJS-UHFFFAOYSA-N 0.000 description 1
- NIONDZDPPYHYKY-SNAWJCMRSA-N (2E)-hexenoic acid Chemical compound CCC\C=C\C(O)=O NIONDZDPPYHYKY-SNAWJCMRSA-N 0.000 description 1
- JZQKTMZYLHNFPL-BLHCBFLLSA-N (2E,4E)-deca-2,4-dienal Chemical compound CCCCC\C=C\C=C\C=O JZQKTMZYLHNFPL-BLHCBFLLSA-N 0.000 description 1
- 239000001890 (2R)-8,8,8a-trimethyl-2-prop-1-en-2-yl-1,2,3,4,6,7-hexahydronaphthalene Substances 0.000 description 1
- ZHHYXNZJDGDGPJ-BSWSSELBSA-N (2e,4e)-nona-2,4-dienal Chemical compound CCCC\C=C\C=C\C=O ZHHYXNZJDGDGPJ-BSWSSELBSA-N 0.000 description 1
- VYPONAGZHAJHGT-ZBJFTSOASA-N (2r)-2-[(z)-pent-2-enyl]-2,3-dihydropyran-6-one Chemical compound CC\C=C/C[C@@H]1CC=CC(=O)O1 VYPONAGZHAJHGT-ZBJFTSOASA-N 0.000 description 1
- SDOFMBGMRVAJNF-KVTDHHQDSA-N (2r,3r,4r,5r)-6-aminohexane-1,2,3,4,5-pentol Chemical compound NC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO SDOFMBGMRVAJNF-KVTDHHQDSA-N 0.000 description 1
- AOFUBOWZWQFQJU-SNOJBQEQSA-N (2r,3s,4s,5r)-2,5-bis(hydroxymethyl)oxolane-2,3,4-triol;(2s,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O.OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O AOFUBOWZWQFQJU-SNOJBQEQSA-N 0.000 description 1
- RMLYXMMBIZLGAQ-HZMBPMFUSA-N (2s,4s)-4-amino-2-hydroxy-2-(1h-indol-3-ylmethyl)pentanedioic acid Chemical compound C1=CC=C2C(C[C@](O)(C[C@H](N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-HZMBPMFUSA-N 0.000 description 1
- XKXZHTWOHXJEOL-UHFFFAOYSA-N (4R,5S,8S,9S,10S,13R)-16,17-Dihydroxykauran-19-oic acid beta-D-glucopyranosyl ester Natural products C1C(C(O)(CO)C2)CCC3C12CCC1C3(C)CCCC1(C)C(=O)OC1OC(CO)C(O)C(O)C1O XKXZHTWOHXJEOL-UHFFFAOYSA-N 0.000 description 1
- 239000001352 (6R)-6-pentyl-5,6-dihydropyran-2-one Substances 0.000 description 1
- YKSSSKBJDZDZTD-XVNBXDOJSA-N (E)-isoeugenyl benzyl ether Chemical compound COC1=CC(\C=C\C)=CC=C1OCC1=CC=CC=C1 YKSSSKBJDZDZTD-XVNBXDOJSA-N 0.000 description 1
- MTVBNJVZZAQKRV-BJMVGYQFSA-N (e)-2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol Chemical compound OCC(/C)=C/CC1CC=C(C)C1(C)C MTVBNJVZZAQKRV-BJMVGYQFSA-N 0.000 description 1
- DYLIWHYUXAJDOJ-OWOJBTEDSA-N (e)-4-(6-aminopurin-9-yl)but-2-en-1-ol Chemical compound NC1=NC=NC2=C1N=CN2C\C=C\CO DYLIWHYUXAJDOJ-OWOJBTEDSA-N 0.000 description 1
- RLWJIETUBNSFMD-VMPITWQZSA-N (e)-n-[2-(1,3-benzodioxol-5-yl)ethyl]-3-(3,4-dimethoxyphenyl)prop-2-enamide Chemical compound C1=C(OC)C(OC)=CC=C1\C=C\C(=O)NCCC1=CC=C(OCO2)C2=C1 RLWJIETUBNSFMD-VMPITWQZSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N 1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylic acid Chemical compound C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- VPKMGDRERYMTJX-CMDGGOBGSA-N 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-1-penten-3-one Chemical compound CCC(=O)\C=C\C1C(C)=CCCC1(C)C VPKMGDRERYMTJX-CMDGGOBGSA-N 0.000 description 1
- JCPGMXJLFWGRMZ-UHFFFAOYSA-N 1-(2-hydroxyphenyl)-3-phenylpropan-1-one Chemical compound OC1=CC=CC=C1C(=O)CCC1=CC=CC=C1 JCPGMXJLFWGRMZ-UHFFFAOYSA-N 0.000 description 1
- WCIQNYOXLZQQMU-UHFFFAOYSA-N 1-Phenylethyl propanoate Chemical compound CCC(=O)OC(C)C1=CC=CC=C1 WCIQNYOXLZQQMU-UHFFFAOYSA-N 0.000 description 1
- GODZNYBQGNSJJN-UHFFFAOYSA-N 1-aminoethane-1,2-diol Chemical compound NC(O)CO GODZNYBQGNSJJN-UHFFFAOYSA-N 0.000 description 1
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 239000001169 1-methyl-4-propan-2-ylcyclohexa-1,4-diene Substances 0.000 description 1
- BVCJCXDURKPQLB-UHFFFAOYSA-N 1-methylsulfanylhexan-1-ol Chemical class CCCCCC(O)SC BVCJCXDURKPQLB-UHFFFAOYSA-N 0.000 description 1
- 239000001351 1-phenylethyl propanoate Substances 0.000 description 1
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 1
- HVNICCSXGONRCB-UHFFFAOYSA-N 2,2-dimethylfuran-3-one Chemical compound CC1(C)OC=CC1=O HVNICCSXGONRCB-UHFFFAOYSA-N 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N 2,3,4,5-tetrahydroxypentanal Chemical compound OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 1
- BAMPVSWRQZNDQC-UHFFFAOYSA-N 2,4,5-trimethylthiazole Chemical class CC1=NC(C)=C(C)S1 BAMPVSWRQZNDQC-UHFFFAOYSA-N 0.000 description 1
- ARGCQEVBJHPOGB-UHFFFAOYSA-N 2,5-dihydrofuran Chemical compound C1OCC=C1 ARGCQEVBJHPOGB-UHFFFAOYSA-N 0.000 description 1
- LOVYCUYJRWLTSU-UHFFFAOYSA-N 2-(3,4-dichlorophenoxy)-n,n-diethylethanamine Chemical compound CCN(CC)CCOC1=CC=C(Cl)C(Cl)=C1 LOVYCUYJRWLTSU-UHFFFAOYSA-N 0.000 description 1
- 239000001278 2-(5-ethenyl-5-methyloxolan-2-yl)propan-2-ol Substances 0.000 description 1
- DNRJTBAOUJJKDY-UHFFFAOYSA-N 2-Acetyl-3,5,5,6,8,8-hexamethyl-5,6,7,8- tetrahydronaphthalene Chemical compound CC(=O)C1=C(C)C=C2C(C)(C)C(C)CC(C)(C)C2=C1 DNRJTBAOUJJKDY-UHFFFAOYSA-N 0.000 description 1
- OXQGTIUCKGYOAA-UHFFFAOYSA-N 2-Ethylbutanoic acid Chemical compound CCC(CC)C(O)=O OXQGTIUCKGYOAA-UHFFFAOYSA-N 0.000 description 1
- ZFFTZDQKIXPDAF-UHFFFAOYSA-N 2-Furanmethanethiol Chemical compound SCC1=CC=CO1 ZFFTZDQKIXPDAF-UHFFFAOYSA-N 0.000 description 1
- RUYNUXHHUVUINQ-UHFFFAOYSA-N 2-Methyl-3-furanthiol Chemical class CC=1OC=CC=1S RUYNUXHHUVUINQ-UHFFFAOYSA-N 0.000 description 1
- HSDXVAOHEOSTFZ-UHFFFAOYSA-N 2-Pentylpyridine Chemical class CCCCCC1=CC=CC=N1 HSDXVAOHEOSTFZ-UHFFFAOYSA-N 0.000 description 1
- MJTPMXWJHPOWGH-UHFFFAOYSA-N 2-Phenoxyethyl isobutyrate Chemical compound CC(C)C(=O)OCCOC1=CC=CC=C1 MJTPMXWJHPOWGH-UHFFFAOYSA-N 0.000 description 1
- RCSBILYQLVXLJG-UHFFFAOYSA-N 2-Propenyl hexanoate Chemical compound CCCCCC(=O)OCC=C RCSBILYQLVXLJG-UHFFFAOYSA-N 0.000 description 1
- QMIBAVZANYVPEF-UHFFFAOYSA-N 2-[[(benzhydrylamino)-(3,5-dichloroanilino)methylidene]amino]acetic acid Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)N=C(NCC(=O)O)NC1=CC(Cl)=CC(Cl)=C1 QMIBAVZANYVPEF-UHFFFAOYSA-N 0.000 description 1
- TXBCBTDQIULDIA-UHFFFAOYSA-N 2-[[3-hydroxy-2,2-bis(hydroxymethyl)propoxy]methyl]-2-(hydroxymethyl)propane-1,3-diol Chemical compound OCC(CO)(CO)COCC(CO)(CO)CO TXBCBTDQIULDIA-UHFFFAOYSA-N 0.000 description 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 1
- MOEFFSWKSMRFRQ-UHFFFAOYSA-N 2-ethoxyphenol Chemical compound CCOC1=CC=CC=C1O MOEFFSWKSMRFRQ-UHFFFAOYSA-N 0.000 description 1
- OFLXNHNYPQPQKW-UHFFFAOYSA-N 2-isopropyl-4-methylthiazole Chemical compound CC(C)C1=NC(C)=CS1 OFLXNHNYPQPQKW-UHFFFAOYSA-N 0.000 description 1
- OQVAOEIMSKZGAL-UHFFFAOYSA-N 2-methyl-3-methylsulfanylfuran Chemical compound CSC=1C=COC=1C OQVAOEIMSKZGAL-UHFFFAOYSA-N 0.000 description 1
- 125000004493 2-methylbut-1-yl group Chemical group CC(C*)CC 0.000 description 1
- FAYUQJQOHOTTKW-UHFFFAOYSA-N 2-methylfuran-3-one Chemical class CC1OC=CC1=O FAYUQJQOHOTTKW-UHFFFAOYSA-N 0.000 description 1
- DNOUKPGPAUUCPC-UHFFFAOYSA-N 2-methylsulfanylpropanal Chemical compound CSC(C)C=O DNOUKPGPAUUCPC-UHFFFAOYSA-N 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- JZQKTMZYLHNFPL-UHFFFAOYSA-N 2-trans-4-trans-decadienal Natural products CCCCCC=CC=CC=O JZQKTMZYLHNFPL-UHFFFAOYSA-N 0.000 description 1
- VMUXSMXIQBNMGZ-UHFFFAOYSA-N 3,4-dihydrocoumarin Chemical compound C1=CC=C2OC(=O)CCC2=C1 VMUXSMXIQBNMGZ-UHFFFAOYSA-N 0.000 description 1
- YLGCZMOAYIGIPX-UHFFFAOYSA-N 3,6-dimethylcyclohex-3-ene-1-carbaldehyde Chemical compound CC1CC=C(C)CC1C=O YLGCZMOAYIGIPX-UHFFFAOYSA-N 0.000 description 1
- SYANLIPWRAZCRF-UHFFFAOYSA-N 3-(1-hydroxycyclohexa-2,4-dien-1-yl)-1-phenylprop-2-en-1-one Chemical class C=1C=CC=CC=1C(=O)C=CC1(O)CC=CC=C1 SYANLIPWRAZCRF-UHFFFAOYSA-N 0.000 description 1
- URQMEZRQHLCJKR-UHFFFAOYSA-N 3-Methyl-5-propyl-2-cyclohexen-1-one Chemical compound CCCC1CC(C)=CC(=O)C1 URQMEZRQHLCJKR-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- SQMHGSIWNHEKQW-UHFFFAOYSA-N 3-benzyl-3-hydroxy-4-phenylbutan-2-one Chemical compound C=1C=CC=CC=1CC(O)(C(=O)C)CC1=CC=CC=C1 SQMHGSIWNHEKQW-UHFFFAOYSA-N 0.000 description 1
- OHCUKMQIGXRSDW-UHFFFAOYSA-N 3-ethyloctan-3-ylphosphonic acid Chemical compound CCCCCC(CC)(CC)P(O)(O)=O OHCUKMQIGXRSDW-UHFFFAOYSA-N 0.000 description 1
- ULUMEKOYNKRJKI-UHFFFAOYSA-N 3-ethylpyrazine Chemical compound CCC1=CN=C=C[N]1 ULUMEKOYNKRJKI-UHFFFAOYSA-N 0.000 description 1
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 description 1
- BGTBFNDXYDYBEY-FNORWQNLSA-N 4-(2,6,6-Trimethylcyclohex-1-enyl)but-2-en-4-one Chemical compound C\C=C\C(=O)C1=C(C)CCCC1(C)C BGTBFNDXYDYBEY-FNORWQNLSA-N 0.000 description 1
- PWASYRSZCSTUIW-UHFFFAOYSA-N 4-(2-methylpropoxy)benzaldehyde Chemical compound CC(C)COC1=CC=C(C=O)C=C1 PWASYRSZCSTUIW-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- ORMHZBNNECIKOH-UHFFFAOYSA-N 4-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde Chemical compound CC(C)(O)CCCC1=CCC(C=O)CC1 ORMHZBNNECIKOH-UHFFFAOYSA-N 0.000 description 1
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
- OSFGNTLIOUHOKN-UHFFFAOYSA-N 4-[benzyl(methyl)sulfamoyl]benzoic acid Chemical compound C=1C=C(C(O)=O)C=CC=1S(=O)(=O)N(C)CC1=CC=CC=C1 OSFGNTLIOUHOKN-UHFFFAOYSA-N 0.000 description 1
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 description 1
- DALUCNUGMDNXET-UHFFFAOYSA-N 5-Ethyl-2,4-dimethylthiazole Chemical compound CCC=1SC(C)=NC=1C DALUCNUGMDNXET-UHFFFAOYSA-N 0.000 description 1
- OUDFNZMQXZILJD-UHFFFAOYSA-N 5-methyl-2-furaldehyde Chemical compound CC1=CC=C(C=O)O1 OUDFNZMQXZILJD-UHFFFAOYSA-N 0.000 description 1
- DFZCBMOGIYUCLI-UHFFFAOYSA-N 5-methylfuran-3(2h)-one Chemical compound CC1=CC(=O)CO1 DFZCBMOGIYUCLI-UHFFFAOYSA-N 0.000 description 1
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 235000011470 Adenanthera pavonina Nutrition 0.000 description 1
- 240000001606 Adenanthera pavonina Species 0.000 description 1
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 229920000310 Alpha glucan Polymers 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 235000003092 Artemisia dracunculus Nutrition 0.000 description 1
- 240000001851 Artemisia dracunculus Species 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 description 1
- 241000193755 Bacillus cereus Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 235000021533 Beta vulgaris Nutrition 0.000 description 1
- 241000335053 Beta vulgaris Species 0.000 description 1
- 244000233287 Beta vulgaris ssp maritima Species 0.000 description 1
- 235000003854 Beta vulgaris ssp. maritima Nutrition 0.000 description 1
- MMGXGNVJAOFJNK-UHFFFAOYSA-N C(C)(=O)O.C1(=CC=CC=C1)OC(=O)Cl Chemical compound C(C)(=O)O.C1(=CC=CC=C1)OC(=O)Cl MMGXGNVJAOFJNK-UHFFFAOYSA-N 0.000 description 1
- RHFMUDZAXHQGJN-UHFFFAOYSA-N C(OC1=CC=CC=C1)(=O)Cl.C(CC(C)C)(=O)O Chemical compound C(OC1=CC=CC=C1)(=O)Cl.C(CC(C)C)(=O)O RHFMUDZAXHQGJN-UHFFFAOYSA-N 0.000 description 1
- CMDQXMQIBUOSDS-UHFFFAOYSA-N C1(=CC=CC=C1)O.BrC1=C(C=CC=C1)Cl Chemical compound C1(=CC=CC=C1)O.BrC1=C(C=CC=C1)Cl CMDQXMQIBUOSDS-UHFFFAOYSA-N 0.000 description 1
- OJRUSAPKCPIVBY-KQYNXXCUSA-N C1=NC2=C(N=C(N=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(CP(=O)(O)O)O)O)O)I)N Chemical compound C1=NC2=C(N=C(N=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(CP(=O)(O)O)O)O)O)I)N OJRUSAPKCPIVBY-KQYNXXCUSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 235000007571 Cananga odorata Nutrition 0.000 description 1
- 240000007436 Cananga odorata Species 0.000 description 1
- 241000644798 Canarium <sea snail> Species 0.000 description 1
- 240000005209 Canarium indicum Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- RPRPDTXKGSIXMD-UHFFFAOYSA-N Caproic acid n-butyl ester Natural products CCCCCC(=O)OCCCC RPRPDTXKGSIXMD-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 241001090476 Castoreum Species 0.000 description 1
- 241000218645 Cedrus Species 0.000 description 1
- 229920001412 Chicle Polymers 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- JOZKFWLRHCDGJA-LLVKDONJSA-N Citronellyl acetate Natural products CC(=O)OCC[C@H](C)CCC=C(C)C JOZKFWLRHCDGJA-LLVKDONJSA-N 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 235000019499 Citrus oil Nutrition 0.000 description 1
- 241000675108 Citrus tangerina Species 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 241000732800 Cymbidium Species 0.000 description 1
- CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 1
- MNQZXJOMYWMBOU-VKHMYHEASA-N D-glyceraldehyde Chemical compound OC[C@@H](O)C=O MNQZXJOMYWMBOU-VKHMYHEASA-N 0.000 description 1
- ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- QWIZNVHXZXRPDR-UHFFFAOYSA-N D-melezitose Natural products O1C(CO)C(O)C(O)C(O)C1OC1C(O)C(CO)OC1(CO)OC1OC(CO)C(O)C(O)C1O QWIZNVHXZXRPDR-UHFFFAOYSA-N 0.000 description 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 description 1
- 229930182832 D-phenylalanine Natural products 0.000 description 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
- UNXHWFMMPAWVPI-QWWZWVQMSA-N D-threitol Chemical compound OC[C@@H](O)[C@H](O)CO UNXHWFMMPAWVPI-QWWZWVQMSA-N 0.000 description 1
- 235000018783 Dacrycarpus dacrydioides Nutrition 0.000 description 1
- 244000288671 Dacrycarpus dacrydioides Species 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 235000018602 Elettaria cardamomum Nutrition 0.000 description 1
- 240000002943 Elettaria cardamomum Species 0.000 description 1
- DWONJCNDULPHLV-HOTGVXAUSA-N Enterodiol Chemical compound C([C@@H](CO)[C@H](CO)CC=1C=C(O)C=CC=1)C1=CC=CC(O)=C1 DWONJCNDULPHLV-HOTGVXAUSA-N 0.000 description 1
- AOJXPBNHAJMETF-UHFFFAOYSA-N Enterodiol Natural products OCC(Cc1ccc(O)cc1)C(CO)Cc2ccc(O)cc2 AOJXPBNHAJMETF-UHFFFAOYSA-N 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- YXAGIRHBJJLWHW-UHFFFAOYSA-N Ethyl 2-ethylhexanoate Chemical group CCCCC(CC)C(=O)OCC YXAGIRHBJJLWHW-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- ZFDIRQKJPRINOQ-HWKANZROSA-N Ethyl crotonate Chemical compound CCOC(=O)\C=C\C ZFDIRQKJPRINOQ-HWKANZROSA-N 0.000 description 1
- YIKYNHJUKRTCJL-UHFFFAOYSA-N Ethyl maltol Chemical compound CCC=1OC=CC(=O)C=1O YIKYNHJUKRTCJL-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 1
- 239000001512 FEMA 4601 Substances 0.000 description 1
- 239000001776 FEMA 4720 Substances 0.000 description 1
- 241000116713 Ferula gummosa Species 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- SNVFDPHQAOXWJZ-UHFFFAOYSA-N Furcelleran Chemical compound CCOC(=O)C1=C(C)NC(C=2C=CC=CC=2)=C(C(=O)OCC=2C=CC=CC=2)C1C#CC1=CC=CC=C1 SNVFDPHQAOXWJZ-UHFFFAOYSA-N 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- UXAIJXIHZDZMSK-FOWTUZBSSA-N Geranyl phenylacetate Chemical compound CC(C)=CCC\C(C)=C\COC(=O)CC1=CC=CC=C1 UXAIJXIHZDZMSK-FOWTUZBSSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- HYQNKKAJVPMBDR-HIFRSBDPSA-N Hernandulcin Chemical compound CC(C)=CCC[C@](C)(O)[C@@H]1CCC(C)=CC1=O HYQNKKAJVPMBDR-HIFRSBDPSA-N 0.000 description 1
- HYQNKKAJVPMBDR-UHFFFAOYSA-N Hernandulcin Natural products CC(C)=CCCC(C)(O)C1CCC(C)=CC1=O HYQNKKAJVPMBDR-UHFFFAOYSA-N 0.000 description 1
- 241000282375 Herpestidae Species 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- OUGPMNMLWKSBRI-UHFFFAOYSA-N Hexyl formate Chemical compound CCCCCCOC=O OUGPMNMLWKSBRI-UHFFFAOYSA-N 0.000 description 1
- 101000801619 Homo sapiens Long-chain-fatty-acid-CoA ligase ACSBG1 Proteins 0.000 description 1
- 235000014486 Hydrangea macrophylla Nutrition 0.000 description 1
- 244000267823 Hydrangea macrophylla Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- VHOQXEIFYTTXJU-UHFFFAOYSA-N Isobutylene-isoprene copolymer Chemical compound CC(C)=C.CC(=C)C=C VHOQXEIFYTTXJU-UHFFFAOYSA-N 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- BJIOGJUNALELMI-ONEGZZNKSA-N Isoeugenol Natural products COC1=CC(\C=C\C)=CC=C1O BJIOGJUNALELMI-ONEGZZNKSA-N 0.000 description 1
- AMIMRNSIRUDHCM-UHFFFAOYSA-N Isopropylaldehyde Chemical compound CC(C)C=O AMIMRNSIRUDHCM-UHFFFAOYSA-N 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- YVRYZXAHRGGELT-UHFFFAOYSA-N Lariciresinol Natural products C1=C2OCOC2=CC(C2C(C)C3(OC)C=C(CC=C)C(=O)CC3(O2)OC)=C1 YVRYZXAHRGGELT-UHFFFAOYSA-N 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 241000192132 Leuconostoc Species 0.000 description 1
- 241000192130 Leuconostoc mesenteroides Species 0.000 description 1
- BRHDDEIRQPDPMG-UHFFFAOYSA-N Linalyl oxide Chemical compound CC(C)(O)C1CCC(C)(C=C)O1 BRHDDEIRQPDPMG-UHFFFAOYSA-N 0.000 description 1
- 244000292467 Lippia dulcis Species 0.000 description 1
- 235000000144 Lippia dulcis Nutrition 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 102100033564 Long-chain-fatty-acid-CoA ligase ACSBG1 Human genes 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 240000002636 Manilkara bidentata Species 0.000 description 1
- 240000001794 Manilkara zapota Species 0.000 description 1
- 235000011339 Manilkara zapota Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 1
- WKSXRWSOSLGSTN-UHFFFAOYSA-N Methoxypyrazine Chemical compound COC1=CN=CC=N1 WKSXRWSOSLGSTN-UHFFFAOYSA-N 0.000 description 1
- KWKVAGQCDSHWFK-VNKDHWASSA-N Methyl sorbate Chemical compound COC(=O)\C=C\C=C\C KWKVAGQCDSHWFK-VNKDHWASSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 101710084933 Miraculin Proteins 0.000 description 1
- 235000009815 Momordica Nutrition 0.000 description 1
- 241000218984 Momordica Species 0.000 description 1
- 241000594464 Mycetia Species 0.000 description 1
- 241001057584 Myrrha Species 0.000 description 1
- 239000004384 Neotame Substances 0.000 description 1
- GLZPCOQZEFWAFX-JXMROGBWSA-N Nerol Natural products CC(C)=CCC\C(C)=C\CO GLZPCOQZEFWAFX-JXMROGBWSA-N 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241001495453 Parthenium argentatum Species 0.000 description 1
- 101000865553 Pentadiplandra brazzeana Defensin-like protein Proteins 0.000 description 1
- 241000199919 Phaeophyceae Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 235000008591 Pinus cembroides var edulis Nutrition 0.000 description 1
- 244000003118 Pinus cembroides var. edulis Species 0.000 description 1
- 241000209504 Poaceae Species 0.000 description 1
- 229920001100 Polydextrose Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- PXRCIOIWVGAZEP-UHFFFAOYSA-N Primaeres Camphenhydrat Natural products C1CC2C(O)(C)C(C)(C)C1C2 PXRCIOIWVGAZEP-UHFFFAOYSA-N 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 description 1
- 235000009984 Pterocarpus indicus Nutrition 0.000 description 1
- 244000086363 Pterocarpus indicus Species 0.000 description 1
- NZGWDASTMWDZIW-UHFFFAOYSA-N Pulegone Natural products CC1CCC(=C(C)C)C(=O)C1 NZGWDASTMWDZIW-UHFFFAOYSA-N 0.000 description 1
- 241000220324 Pyrus Species 0.000 description 1
- HELXLJCILKEWJH-SEAGSNCFSA-N Rebaudioside A Natural products O=C(O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HELXLJCILKEWJH-SEAGSNCFSA-N 0.000 description 1
- JVWLUVNSQYXYBE-UHFFFAOYSA-N Ribitol Natural products OCC(C)C(O)C(O)CO JVWLUVNSQYXYBE-UHFFFAOYSA-N 0.000 description 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
- OZNUPWACHHUIKC-UHFFFAOYSA-N Rubemamine Natural products C1=C(OC)C(OC)=CC=C1CCNC(=O)C=CC1=CC=C(OC)C(OC)=C1 OZNUPWACHHUIKC-UHFFFAOYSA-N 0.000 description 1
- 235000011034 Rubus glaucus Nutrition 0.000 description 1
- 244000235659 Rubus idaeus Species 0.000 description 1
- 235000009122 Rubus idaeus Nutrition 0.000 description 1
- YRTWNLRWBFWCGZ-UHFFFAOYSA-N S(=O)(=O)(O)CCC(CCC)=O Chemical class S(=O)(=O)(O)CCC(CCC)=O YRTWNLRWBFWCGZ-UHFFFAOYSA-N 0.000 description 1
- GRLJIIJNZJVMGP-UHFFFAOYSA-N S-Methyl butanethioate Chemical compound CCCC(=O)SC GRLJIIJNZJVMGP-UHFFFAOYSA-N 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N Salicylic acid Natural products OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 1
- 235000005794 Salvia japonica Nutrition 0.000 description 1
- 244000295490 Salvia japonica Species 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 239000004283 Sodium sorbate Substances 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 241000121220 Tricholoma matsutake Species 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- YPFDHNVEDLHUCE-UHFFFAOYSA-N Trimethylene glycol Natural products OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- VYPONAGZHAJHGT-UHFFFAOYSA-N Tuberolactone Natural products CCC=CCC1CC=CC(=O)O1 VYPONAGZHAJHGT-UHFFFAOYSA-N 0.000 description 1
- MUCRYNWJQNHDJH-OADIDDRXSA-N Ursonic acid Chemical compound C1CC(=O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C MUCRYNWJQNHDJH-OADIDDRXSA-N 0.000 description 1
- 241000792914 Valeriana Species 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 241000589636 Xanthomonas campestris Species 0.000 description 1
- 235000010688 Yerba dulce Nutrition 0.000 description 1
- 244000166283 Yerba dulce Species 0.000 description 1
- NIONDZDPPYHYKY-UHFFFAOYSA-N Z-hexenoic acid Natural products CCCC=CC(O)=O NIONDZDPPYHYKY-UHFFFAOYSA-N 0.000 description 1
- LMETVDMCIJNNKH-UHFFFAOYSA-N [(3,7-Dimethyl-6-octenyl)oxy]acetaldehyde Chemical compound CC(C)=CCCC(C)CCOCC=O LMETVDMCIJNNKH-UHFFFAOYSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 235000010358 acesulfame potassium Nutrition 0.000 description 1
- 229960004998 acesulfame potassium Drugs 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 229940022663 acetate Drugs 0.000 description 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- PYMYPHUHKUWMLA-VAYJURFESA-N aldehydo-L-arabinose Chemical compound OC[C@H](O)[C@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-VAYJURFESA-N 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 229910000318 alkali metal phosphate Inorganic materials 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- OOCCDEMITAIZTP-UHFFFAOYSA-N allylic benzylic alcohol Natural products OCC=CC1=CC=CC=C1 OOCCDEMITAIZTP-UHFFFAOYSA-N 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 108090000637 alpha-Amylases Proteins 0.000 description 1
- 102000004139 alpha-Amylases Human genes 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- WQZGKKKJIJFFOK-DVKNGEFBSA-N alpha-D-glucose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-DVKNGEFBSA-N 0.000 description 1
- XCPQUQHBVVXMRQ-UHFFFAOYSA-N alpha-Fenchene Natural products C1CC2C(=C)CC1C2(C)C XCPQUQHBVVXMRQ-UHFFFAOYSA-N 0.000 description 1
- 229940024171 alpha-amylase Drugs 0.000 description 1
- MVNCAPSFBDBCGF-UHFFFAOYSA-N alpha-pinene Natural products CC1=CCC23C1CC2C3(C)C MVNCAPSFBDBCGF-UHFFFAOYSA-N 0.000 description 1
- USMNOWBWPHYOEA-UHFFFAOYSA-N alpha-thujone Natural products CC1C(=O)CC2(C(C)C)C1C2 USMNOWBWPHYOEA-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000019824 amidated pectin Nutrition 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- 239000001181 artemisia dracunculus Substances 0.000 description 1
- 125000000254 aspartoyl group Chemical group 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 235000016302 balata Nutrition 0.000 description 1
- 235000013527 bean curd Nutrition 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
- 229960002903 benzyl benzoate Drugs 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- 108010019077 beta-Amylase Proteins 0.000 description 1
- NOPLRNXKHZRXHT-YFVJMOTDSA-N beta-Sinensal Chemical compound O=CC(/C)=C/CCC(/C)=C/CCC(=C)C=C NOPLRNXKHZRXHT-YFVJMOTDSA-N 0.000 description 1
- POIARNZEYGURDG-FNORWQNLSA-N beta-damascenone Chemical compound C\C=C\C(=O)C1=C(C)C=CCC1(C)C POIARNZEYGURDG-FNORWQNLSA-N 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 1
- BFAKENXZKHGIGE-UHFFFAOYSA-N bis(2,3,5,6-tetrafluoro-4-iodophenyl)diazene Chemical compound FC1=C(C(=C(C(=C1F)I)F)F)N=NC1=C(C(=C(C(=C1F)F)I)F)F BFAKENXZKHGIGE-UHFFFAOYSA-N 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 239000001055 blue pigment Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 235000013532 brandy Nutrition 0.000 description 1
- 235000015496 breakfast cereal Nutrition 0.000 description 1
- 235000010634 bubble gum Nutrition 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000012928 buffer substance Substances 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000010410 calcium alginate Nutrition 0.000 description 1
- 239000000648 calcium alginate Substances 0.000 description 1
- 229960002681 calcium alginate Drugs 0.000 description 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 1
- 239000001354 calcium citrate Substances 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- GUPPESBEIQALOS-ZVGUSBNCSA-L calcium;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Ca+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O GUPPESBEIQALOS-ZVGUSBNCSA-L 0.000 description 1
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 1
- 229930006739 camphene Natural products 0.000 description 1
- ZYPYEBYNXWUCEA-UHFFFAOYSA-N camphenilone Natural products C1CC2C(=O)C(C)(C)C1C2 ZYPYEBYNXWUCEA-UHFFFAOYSA-N 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000010628 chamomile oil Substances 0.000 description 1
- 235000019480 chamomile oil Nutrition 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- CCRCUPLGCSFEDV-UHFFFAOYSA-N cinnamic acid methyl ester Natural products COC(=O)C=CC1=CC=CC=C1 CCRCUPLGCSFEDV-UHFFFAOYSA-N 0.000 description 1
- WJSDHUCWMSHDCR-VMPITWQZSA-N cinnamyl acetate Natural products CC(=O)OC\C=C\C1=CC=CC=C1 WJSDHUCWMSHDCR-VMPITWQZSA-N 0.000 description 1
- NNWHUJCUHAELCL-UHFFFAOYSA-N cis-Methyl isoeugenol Natural products COC1=CC=C(C=CC)C=C1OC NNWHUJCUHAELCL-UHFFFAOYSA-N 0.000 description 1
- BJIOGJUNALELMI-ARJAWSKDSA-N cis-isoeugenol Chemical compound COC1=CC(\C=C/C)=CC=C1O BJIOGJUNALELMI-ARJAWSKDSA-N 0.000 description 1
- NNWHUJCUHAELCL-PLNGDYQASA-N cis-isomethyleugenol Chemical compound COC1=CC=C(\C=C/C)C=C1OC NNWHUJCUHAELCL-PLNGDYQASA-N 0.000 description 1
- 239000001507 cistus ladaniferus l. oil Substances 0.000 description 1
- 229940069078 citric acid / sodium citrate Drugs 0.000 description 1
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Substances 0.000 description 1
- 239000010500 citrus oil Substances 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 229910052570 clay Inorganic materials 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 229910052681 coesite Inorganic materials 0.000 description 1
- 235000016213 coffee Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 235000020057 cognac Nutrition 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 235000014510 cooky Nutrition 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 229960000956 coumarin Drugs 0.000 description 1
- 229910052906 cristobalite Inorganic materials 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 108010010165 curculin Proteins 0.000 description 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 125000000422 delta-lactone group Chemical group 0.000 description 1
- FYTRVXSHONWYNE-UHFFFAOYSA-N delta-octanolide Chemical compound CCCC1CCCC(=O)O1 FYTRVXSHONWYNE-UHFFFAOYSA-N 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- DMSHWWDRAYHEBS-UHFFFAOYSA-N dihydrocoumarin Natural products C1CC(=O)OC2=C1C=C(OC)C(OC)=C2 DMSHWWDRAYHEBS-UHFFFAOYSA-N 0.000 description 1
- XSNQECSCDATQEL-UHFFFAOYSA-N dihydromyrcenol Chemical compound C=CC(C)CCCC(C)(C)O XSNQECSCDATQEL-UHFFFAOYSA-N 0.000 description 1
- 229930008394 dihydromyrcenol Natural products 0.000 description 1
- 125000001891 dimethoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- FBSAITBEAPNWJG-UHFFFAOYSA-N dimethyl phthalate Natural products CC(=O)OC1=CC=CC=C1OC(C)=O FBSAITBEAPNWJG-UHFFFAOYSA-N 0.000 description 1
- 229960001826 dimethylphthalate Drugs 0.000 description 1
- 239000001177 diphosphate Substances 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 150000002019 disulfides Chemical class 0.000 description 1
- 150000004141 diterpene derivatives Chemical class 0.000 description 1
- WTOYNNBCKUYIKC-UHFFFAOYSA-N dl-nootkatone Natural products C1CC(C(C)=C)CC2(C)C(C)CC(=O)C=C21 WTOYNNBCKUYIKC-UHFFFAOYSA-N 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 239000004862 elemi Substances 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- HELXLJCILKEWJH-UHFFFAOYSA-N entered according to Sigma 01432 Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O HELXLJCILKEWJH-UHFFFAOYSA-N 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 description 1
- FTOZMXOHOKRHNL-UHFFFAOYSA-N ethyl 2,3-dihydroxypropanoate Chemical compound CCOC(=O)C(O)CO FTOZMXOHOKRHNL-UHFFFAOYSA-N 0.000 description 1
- HCRBXQFHJMCTLF-UHFFFAOYSA-N ethyl 2-methylbutyrate Chemical compound CCOC(=O)C(C)CC HCRBXQFHJMCTLF-UHFFFAOYSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 229940116333 ethyl lactate Drugs 0.000 description 1
- 229940093503 ethyl maltol Drugs 0.000 description 1
- 235000010944 ethyl methyl cellulose Nutrition 0.000 description 1
- TZMFJUDUGYTVRY-UHFFFAOYSA-N ethyl methyl diketone Natural products CCC(=O)C(C)=O TZMFJUDUGYTVRY-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000010643 fennel seed oil Substances 0.000 description 1
- 150000007946 flavonol Chemical class 0.000 description 1
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 1
- 235000011957 flavonols Nutrition 0.000 description 1
- 229940091249 fluoride supplement Drugs 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 description 1
- 229940107187 fructooligosaccharide Drugs 0.000 description 1
- 235000021433 fructose syrup Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 235000013569 fruit product Nutrition 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- LYINKTVZUSKQEQ-UHFFFAOYSA-N furan-3-one Chemical compound O=C1COC=C1 LYINKTVZUSKQEQ-UHFFFAOYSA-N 0.000 description 1
- MWFFRFMPYAKXEY-UHFFFAOYSA-N furan-3-thiol Chemical compound SC=1C=COC=1 MWFFRFMPYAKXEY-UHFFFAOYSA-N 0.000 description 1
- OALYTRUKMRCXNH-QMMMGPOBSA-N gamma-Nonalactone Natural products CCCCC[C@H]1CCC(=O)O1 OALYTRUKMRCXNH-QMMMGPOBSA-N 0.000 description 1
- IPBFYZQJXZJBFQ-UHFFFAOYSA-N gamma-octalactone Chemical compound CCCCC1CCC(=O)O1 IPBFYZQJXZJBFQ-UHFFFAOYSA-N 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 235000013531 gin Nutrition 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 235000012209 glucono delta-lactone Nutrition 0.000 description 1
- 239000000182 glucono-delta-lactone Substances 0.000 description 1
- 229960003681 gluconolactone Drugs 0.000 description 1
- 230000036252 glycation Effects 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 229960001867 guaiacol Drugs 0.000 description 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 1
- 229910000271 hectorite Inorganic materials 0.000 description 1
- 229940027278 hetastarch Drugs 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 1
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 239000000416 hydrocolloid Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- WPFVBOQKRVRMJB-UHFFFAOYSA-N hydroxycitronellal Chemical compound O=CCC(C)CCCC(C)(C)O WPFVBOQKRVRMJB-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 229920013818 hydroxypropyl guar gum Polymers 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 235000021539 instant coffee Nutrition 0.000 description 1
- 235000014109 instant soup Nutrition 0.000 description 1
- 235000020344 instant tea Nutrition 0.000 description 1
- 230000009878 intermolecular interaction Effects 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- 229940117955 isoamyl acetate Drugs 0.000 description 1
- 229940094941 isoamyl butyrate Drugs 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229940095045 isopulegol Drugs 0.000 description 1
- 239000001851 juniperus communis l. berry oil Substances 0.000 description 1
- BJHIKXHVCXFQLS-PQLUHFTBSA-N keto-D-tagatose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-PQLUHFTBSA-N 0.000 description 1
- 229940001447 lactate Drugs 0.000 description 1
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 1
- 229960000511 lactulose Drugs 0.000 description 1
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 1
- 235000006826 lariciresinol Nutrition 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 235000015122 lemonade Nutrition 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000020094 liqueur Nutrition 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 229920003008 liquid latex Polymers 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- IHKGGKRBWGTNNG-UHFFFAOYSA-N lugduname Chemical compound C=1C=CC=2OCOC=2C=1C/N=C(/NCC(=O)O)NC1=CC=C(C#N)C=C1 IHKGGKRBWGTNNG-UHFFFAOYSA-N 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- 235000000055 matairesinol Nutrition 0.000 description 1
- RNXYRAQIZQGUIK-UHFFFAOYSA-N matairesinol Natural products COc1cc(CC2OCC(=O)C2Cc3ccc(O)c(OC)c3)ccc1O RNXYRAQIZQGUIK-UHFFFAOYSA-N 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000008268 mayonnaise Substances 0.000 description 1
- 235000010746 mayonnaise Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- QWIZNVHXZXRPDR-WSCXOGSTSA-N melezitose Chemical compound O([C@@]1(O[C@@H]([C@H]([C@@H]1O[C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O)CO)CO)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QWIZNVHXZXRPDR-WSCXOGSTSA-N 0.000 description 1
- 239000001098 melissa officinalis l. leaf oil Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 235000011042 metatartaric acid Nutrition 0.000 description 1
- 239000001369 metatartaric acid Substances 0.000 description 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
- GEWDNTWNSAZUDX-UHFFFAOYSA-N methyl 7-epi-jasmonate Natural products CCC=CCC1C(CC(=O)OC)CCC1=O GEWDNTWNSAZUDX-UHFFFAOYSA-N 0.000 description 1
- 229940102398 methyl anthranilate Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- CCRCUPLGCSFEDV-BQYQJAHWSA-N methyl trans-cinnamate Chemical compound COC(=O)\C=C\C1=CC=CC=C1 CCRCUPLGCSFEDV-BQYQJAHWSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- SBENKNZHVXGNTP-UHFFFAOYSA-N methylconiferyl ether Natural products COCC=CC1=CC=C(O)C(OC)=C1 SBENKNZHVXGNTP-UHFFFAOYSA-N 0.000 description 1
- 229920003087 methylethyl cellulose Polymers 0.000 description 1
- JPTOCTSNXXKSSN-UHFFFAOYSA-N methylheptenone Chemical class CCCC=CC(=O)CC JPTOCTSNXXKSSN-UHFFFAOYSA-N 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- CAWHJQAVHZEVTJ-UHFFFAOYSA-N methylpyrazine Chemical compound CC1=CN=CC=N1 CAWHJQAVHZEVTJ-UHFFFAOYSA-N 0.000 description 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229930189775 mogroside Natural products 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- ZYTMANIQRDEHIO-UHFFFAOYSA-N neo-Isopulegol Natural products CC1CCC(C(C)=C)C(O)C1 ZYTMANIQRDEHIO-UHFFFAOYSA-N 0.000 description 1
- 235000019412 neotame Nutrition 0.000 description 1
- HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical compound CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 description 1
- 108010070257 neotame Proteins 0.000 description 1
- HIGQPQRQIQDZMP-FLIBITNWSA-N neryl acetate Chemical compound CC(C)=CCC\C(C)=C/COC(C)=O HIGQPQRQIQDZMP-FLIBITNWSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- NCPWFIVLKCFWSP-UHFFFAOYSA-N nona-2,4-dien-1-ol Chemical class CCCCC=CC=CCO NCPWFIVLKCFWSP-UHFFFAOYSA-N 0.000 description 1
- AMXYRHBJZOVHOL-UHFFFAOYSA-N nona-2,6-dien-1-ol Chemical class CCC=CCCC=CCO AMXYRHBJZOVHOL-UHFFFAOYSA-N 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 239000007968 orange flavor Substances 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000003534 oscillatory effect Effects 0.000 description 1
- 229930007459 p-menth-8-en-3-one Natural products 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001298 pelargonium graveolens oil Substances 0.000 description 1
- LHTVMBMETNGEAN-UHFFFAOYSA-N pent-1-en-1-ol Chemical compound CCCC=CO LHTVMBMETNGEAN-UHFFFAOYSA-N 0.000 description 1
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 1
- YWAKXRMUMFPDSH-UHFFFAOYSA-N pentene Chemical group CCCC=C YWAKXRMUMFPDSH-UHFFFAOYSA-N 0.000 description 1
- 239000007967 peppermint flavor Substances 0.000 description 1
- 150000007875 phellandrene derivatives Chemical class 0.000 description 1
- 229960000969 phenyl salicylate Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229940067107 phenylethyl alcohol Drugs 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 229910052615 phyllosilicate Inorganic materials 0.000 description 1
- 235000021110 pickles Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229930006728 pinane Natural products 0.000 description 1
- XOKSLPVRUOBDEW-UHFFFAOYSA-N pinane of uncertain configuration Natural products CC1CCC2C(C)(C)C1C2 XOKSLPVRUOBDEW-UHFFFAOYSA-N 0.000 description 1
- QPUMEZIFDXYGPG-UHFFFAOYSA-N piperazine 1H-pyrrole Chemical compound N1CCNCC1.N1C=CC=C1 QPUMEZIFDXYGPG-UHFFFAOYSA-N 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 235000013856 polydextrose Nutrition 0.000 description 1
- 239000001259 polydextrose Substances 0.000 description 1
- 229940035035 polydextrose Drugs 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001195 polyisoprene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 229940072033 potash Drugs 0.000 description 1
- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 description 1
- 235000010408 potassium alginate Nutrition 0.000 description 1
- 239000000737 potassium alginate Substances 0.000 description 1
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical compound [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 description 1
- 229940074439 potassium sodium tartrate Drugs 0.000 description 1
- 235000013606 potato chips Nutrition 0.000 description 1
- 235000008476 powdered milk Nutrition 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- XXRYFVCIMARHRS-UHFFFAOYSA-N propan-2-yl n-dimethoxyphosphorylcarbamate Chemical compound COP(=O)(OC)NC(=O)OC(C)C XXRYFVCIMARHRS-UHFFFAOYSA-N 0.000 description 1
- HUAZGNHGCJGYNP-UHFFFAOYSA-N propyl butyrate Chemical compound CCCOC(=O)CCC HUAZGNHGCJGYNP-UHFFFAOYSA-N 0.000 description 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 1
- 235000011962 puddings Nutrition 0.000 description 1
- GRWFGVWFFZKLTI-UHFFFAOYSA-N rac-alpha-Pinene Natural products CC1=CCC2C(C)(C)C1C2 GRWFGVWFFZKLTI-UHFFFAOYSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 235000019203 rebaudioside A Nutrition 0.000 description 1
- 239000001054 red pigment Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229930007790 rose oxide Natural products 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229930000308 sinensal Natural products 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 description 1
- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229960004249 sodium acetate Drugs 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 239000000176 sodium gluconate Substances 0.000 description 1
- 235000012207 sodium gluconate Nutrition 0.000 description 1
- 229940005574 sodium gluconate Drugs 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 235000011006 sodium potassium tartrate Nutrition 0.000 description 1
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 1
- 235000019250 sodium sorbate Nutrition 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- SKORRGYRKQDXRS-UHFFFAOYSA-M sodium;2-(4-methoxyphenoxy)propanoate Chemical compound [Na+].COC1=CC=C(OC(C)C([O-])=O)C=C1 SKORRGYRKQDXRS-UHFFFAOYSA-M 0.000 description 1
- 235000008983 soft cheese Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000021262 sour milk Nutrition 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- DSAJORLEPQBKDA-AWEZNQCLSA-N sterubin Chemical compound C1([C@@H]2CC(=O)C3=C(O)C=C(C=C3O2)OC)=CC=C(O)C(O)=C1 DSAJORLEPQBKDA-AWEZNQCLSA-N 0.000 description 1
- DSAJORLEPQBKDA-UHFFFAOYSA-N sterubin Natural products O1C2=CC(OC)=CC(O)=C2C(=O)CC1C1=CC=C(O)C(O)=C1 DSAJORLEPQBKDA-UHFFFAOYSA-N 0.000 description 1
- QFVOYBUQQBFCRH-VQSWZGCSSA-N steviol Chemical compound C([C@@]1(O)C(=C)C[C@@]2(C1)CC1)C[C@H]2[C@@]2(C)[C@H]1[C@](C)(C(O)=O)CCC2 QFVOYBUQQBFCRH-VQSWZGCSSA-N 0.000 description 1
- 229910052682 stishovite Inorganic materials 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 229930183612 suavioside Natural products 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- LBDVSPIQWSQRLB-UHFFFAOYSA-N sucrononic acid Chemical compound C=1C=C(C#N)C=CC=1\N=C(/NCC(=O)O)NC1CCCCCCCC1 LBDVSPIQWSQRLB-UHFFFAOYSA-N 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 235000010491 tara gum Nutrition 0.000 description 1
- 239000000213 tara gum Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 235000012976 tarts Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- CBDKQYKMCICBOF-UHFFFAOYSA-N thiazoline Chemical compound C1CN=CS1 CBDKQYKMCICBOF-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- BJIOGJUNALELMI-UHFFFAOYSA-N trans-isoeugenol Natural products COC1=CC(C=CC)=CC=C1O BJIOGJUNALELMI-UHFFFAOYSA-N 0.000 description 1
- ZFDIRQKJPRINOQ-UHFFFAOYSA-N transbutenic acid ethyl ester Natural products CCOC(=O)C=CC ZFDIRQKJPRINOQ-UHFFFAOYSA-N 0.000 description 1
- 230000006098 transglycosylation Effects 0.000 description 1
- 238000005918 transglycosylation reaction Methods 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 1
- 239000001393 triammonium citrate Substances 0.000 description 1
- 235000011046 triammonium citrate Nutrition 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
- QXJQHYBHAIHNGG-UHFFFAOYSA-N trimethylolethane Chemical compound OCC(C)(CO)CO QXJQHYBHAIHNGG-UHFFFAOYSA-N 0.000 description 1
- WCTNXGFHEZQHDR-UHFFFAOYSA-N valencene Natural products C1CC(C)(C)C2(C)CC(C(=C)C)CCC2=C1 WCTNXGFHEZQHDR-UHFFFAOYSA-N 0.000 description 1
- 235000017468 valeriana Nutrition 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000010679 vetiver oil Substances 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 229930007850 β-damascenone Natural products 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/36—Terpene glycosides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/84—Flavour masking or reducing agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/88—Taste or flavour enhancing agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01019—Cyclomaltodextrin glucanotransferase (2.4.1.19)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Seasonings (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明提供一种新的物质混合物,其作为香料制剂用于改善口服制剂的甜味。
Description
发明领域
本发明属于食品领域并且涉及新型物质混合物,其用作提高口服制剂甜味的香料制剂。
现有技术
悬钩子苷由植物甜茶(中国黑莓)的叶得到并且是不同二萜甜菊糖苷的复杂混合物。甜叶悬钩子苷用作不含卡路里的甜味剂,纯甜叶悬钩子苷的甜度为糖的200倍。中国黑莓原产于东南亚,其甜度长久已知。目前这种植物在中国的广西和广东地区大范围种植。
含有悬钩子苷作为甜味剂的产品在现有技术中充分已知。通过浓缩方法提高甜叶悬钩子苷含量的尝试同样已知。例如,甜叶悬钩子苷和甜菊醇糖甙的混合物及其作为甜味剂的用途记载于专利申请EP 2641479和WO 2012/177727。
WO 2013/133689的主题是纯化甜菊糖甙的色谱方法。
然而,市售可得悬钩子苷的特征在于它们都具备苦,有时涩的后味并且不充分的甜味效果,使其难以广泛使用。悬钩子苷可用于掩蔽不良的味道印象(EP 2.386.211),然而这种作用对其自身不起作用。使用悬钩子提取物的改良制剂已经记载于EP2.641.479,但是没有改善甜味性能。
之前,分离了α‐葡糖基甜叶悬钩子苷的单一物质并评估其味道(Ohtani.K.;Aikawa.Y.;Ishikawa.H.;Kasai.R.;Kitahata.S.;Mizutani.K.;Doi.S.;Nakaura.M.;Tanaka.O..Further study on the 1.4‐alpha‐transglucosylation of rubusosides.asweet steviol‐bisglucoside from Rubus suavissimus.Agric.Biol.Chem.1991.55.(2).449‐453),然而纯化直至得到单一物质相当复杂并且商业上不合理,从而无法应用。
进一步参考以下现有技术:
JP 2002 045145 A(TOYO SUGAR REFINING)公开了一种提供甜菊提取物的甜味混合物的方法,其主要含有甜菊醇糖甙、莱鲍迪甙A、莱鲍迪甙C、和卫矛醇甙A。在进行该方法中卫矛醇甙A的鼠李糖部分水解,产生甜叶悬钩子苷([0014]),其导致含有少量甜叶悬钩子苷的甜味混合物(表1)。该混合物表现出减小的苦味以及提高的甜味([0019])并因此可用于香料制剂([0035])。此外通过酶反应甜叶悬钩子苷转化为相应的葡糖基化产物([0024])。
出版物Agricultural and Biological Chemistry.Vol.48(10).p 2483‐2488(1984)公开了甜叶悬钩子苷转糖基反应的产物,其不仅含有在反应过程中产生的不同甜叶悬钩子苷‐糖苷,而且含有反应的甜叶悬钩子苷(2484页,第2段)。也记载了通过CGTase***生产糖基化产物并评估其甜味(2486页的实验部分和表1)。
EP 2386211 A1(SYMRISE)的主题是甜叶悬钩子苷以及含有甜叶悬钩子苷的混合物用于掩蔽、减小或抑制苦味、酸味和/或涩味感受的用途([0013]),而提到的混合物还含有一种或多种酚类化合物([0019])。
EP 2353403 A1(SYMRISE)公开了具备甜味的脱氧二氢查耳酮橙皮素用于影响味道强度,提高甜味物质的甜味印象并用于防止或掩蔽不良味道物质的不良味道印象的用途([0024])。
因此本发明的主题是提供新型物质混合物,其增强、改善或优化口服制剂的甜味。特别地,本发明的主题一方面在于通过自然(酶、发酵或烹饪)方法优化悬钩子苷的味道性能,从而得到新的香料制剂。本发明的另一个主题是通过自然方法制备α‐葡糖基甜叶悬钩子苷。由此得到的α‐葡糖基甜叶悬钩子苷,除了优化味道性能,其特征在于在其低浓度下的效率以及增强其他物质甜味的性能。
发明内容
本发明的主题是物质混合物,其含有1重量%至60重量%的至少一种通式(I)的化合物,其中m=n=0,
和至少一种通式(I)的其他化合物,其中m或n≥1,前提是m和n相互独立地为0至50。
在本发明的物质混合物中式(I)化合物优选为悬钩子苷和/或α‐葡糖基甜叶悬钩子苷。
悬钩子苷
悬钩子苷可以,由植物甜茶(中国黑莓)得到,例如EP 2236043,并且至少由甜叶悬钩子二萜苷组成,优选含量为1至100重量%,特别优选10‐95重量%,特别优选30‐75重量%,基于悬钩子苷总重量计,并且可以含有13种现有技术中已知的其他异构体和同系物中的一种或多种,如suavioside A、B和R1,但是部分是苦味(Hirono.S.;Chou.W.H.;Kasai.R.;Tanaka.O.;Tada.T..Sweet and bitter diterpene glucosides from leavesof Rubus suavissimus.Chemical&Pharmaceutical Bulletin 1990.38.(6).1743‐1744und Chou.G.;Xu. S.‐J.;Liu.D.;Koh.G.Y.;Zhang.J.;Liu.Z..Quantitative andFingerprint Analyses of Chinese Sweet Tea Plant(Rubus suavissimus S.Lee).J.Agric Food Chem.2009.57.1076‐1083.)。
所含悬钩子苷部分的区别在于种植区域和植物种类。在生产甜味物质混合物过程中,植物的甘草味道通过分离甜味成分及随后的组合物抵消。悬钩子物通常含有10%‐70%的甜叶悬钩子苷。甜叶悬钩子苷自身也可以通过酶致转变由甜菊糖甙得到,如记载于WO2013/133689。
在本发明中,与现有技术相反,在生产悬钩子苷的1,4‐糖基化碳水化合物,优选为淀粉的转糖基化反应中,优选使用α‐环糊精葡聚糖转移酶(CGTase)。由此可以改变甜菊提取物,从而如WO 2012 112180所记载产生α‐葡糖基甜菊糖甙。但是该反应仍未被用于生产根据本发明的具备改良味道的悬钩子提取物。因此本发明的另一个主题是一种生产根据本发明的物质混合物所含有的悬钩子苷的方法,包括在1,4‐糖基化碳水化合物,优选为糖类的转糖基化反应中使用α‐环糊精葡聚糖转移酶。
α‐葡糖基甜叶悬钩子苷
α‐葡糖基甜叶悬钩子苷是酶致、发酵或化学改性悬钩子苷,特别是通式(I)的甜叶悬钩子苷,并且除了甜叶悬钩子苷中已经含有的两个葡萄糖单元(m=n=0)还含有至少1至20,优选至少2至10并别特别是2至6个额外的葡萄糖单元,其中额外的葡萄糖单元优选为α‐1,4‐连接的D‐吡喃型葡萄糖。
令人惊讶地发现,根据本发明的具备通式(I)的化合物的物质混合物与单独的悬钩子苷相比不仅具备显著改善的甜味效果,而且特别适用于改善、增强和优化口服制剂的初始甜味和充实味道感受。此外还表现出改善的味道性能,特别是在甜度方面,含有本发明物质混合物的制剂与具备减少量的葡萄糖或其他甜味碳水化合物的制剂相比。特别地,令人惊讶地显现,根据本发明的物质混合物与酚类增甜香料物质以及淀粉降解产物结合可以减小和/或遮蔽悬钩子苷和/或α‐葡糖基甜叶悬钩子苷的部分不良的类甜味剂后味。
因此一个优选实施方案是含有至少一个式(I)化合物的根据本发明的物质混合物,其中m=n=0(=甜叶悬钩子苷)
进一步地优选实施方案中的根据本发明的物质混合物含有至少一个式(I)化合物,其中m和n相互独立地为0至50,并且其和m+n>0,m+n≤50。
因此,在优选实施方案中,根据本发明的物质混合物,其含有至少一个m=n=0的式(I)化合物,以及另一个式(I)化合物,其中m和n相互独立地为0至50,并且其和m+n>0,m+n≤50。
在本发明的另一个优选实施方案中,除了至少一个式(I)化合物,其中m和n相互独立地为0至50,并且在m=n=0的情况下,存在另一个m或n≥1的通式(I)的化合物,根据本发明的物质混合物还含有额外的淀粉降解产物。在本文中淀粉降解产物优选含有3至100个α‐1‐4‐连接的D‐吡喃型葡萄糖。
淀粉降解产物
在根据本发明的混合物中适当的淀粉降解产物用作载体物质。优选糊精或麦芽糊精,其分子尺寸介于低聚糖和淀粉之间。通常,它们以白色或淡黄色粉末形式存在。它们主要通过干燥加热(>150℃)或在酸作用下由小麦、土豆和玉米淀粉得到。自然界中由例如浸麻芽孢杆菌(Bacterium macerans)产生糊精。糊精同样通过使用淀粉酶由淀粉酶解产生。
特别适当的麦芽糊精具备约3至约20,优选约5至约15个葡萄糖当量(DE)。这是指干物质中还原糖的百分比。
在本发明的另一个优选实施方案中,根据本发明的物质混合物还额外含有一种或多种酚类天然产生的甜味增强香料物质,选自组包括橙皮素(Hesperetin)、根皮素(Phloretin)、1‐(2,4‐二氢‐苯基)‐3‐(3‐羟基‐4‐甲氧基‐苯基)‐丙‐1‐酮、7,3‐二氢‐4′甲氧基黄烷和5‐羟基‐4‐(4‐羟基‐3‐甲氧基‐苯基)‐7‐甲氧基‐2‐苯并二氢吡喃酮。
在本发明的物质混合物中式(I)化合物优选为悬钩子苷,其优选为甜叶悬钩子苷(m=n=0)或特别优选式(II)的一种α‐糖基化甜叶悬钩子苷
其中残基R1和R2为以下基团:
化合物 | 悬钩子苷 | R1 | R2 |
1 | 悬钩子三葡糖苷 | H‐ | Glcα1‐ |
2 | 悬钩子三葡糖苷 | Glcα1‐ | H‐ |
3 | 悬钩子四葡糖苷 | Glcα1‐ | Glcα1‐ |
4 | 悬钩子四葡糖苷 | ‐Glcα1‐4Glcα | H‐ |
5 | 悬钩子四葡糖苷 | H‐ | ‐Glcα1‐4Glcα |
6 | 悬钩子五葡糖苷 | ‐Glcα1‐4Glcα | Glcα1‐ |
7 | 悬钩子五葡糖苷 | Glcα1‐ | ‐Glcα1‐4Glcα |
8 | 悬钩子六葡糖苷 | ‐Glcα1‐4Glcα | ‐Glcα1‐4Glcα |
9 | 悬钩子五葡糖苷 | ‐Glcα1‐4Glcα1‐4Glcα | H‐ |
10 | 悬钩子五葡糖苷 | H‐ | ‐Glcα1‐4Glcα1‐4Glcα |
11 | 悬钩子六葡糖苷 | ‐Glcα1‐4Glcα1‐4Glcα | Glcα1‐ |
12 | 悬钩子六葡糖苷 | Glcα1‐ | ‐Glcα1‐4Glcα1‐4Glcα |
13 | 悬钩子七葡糖苷 | ‐Glcα1‐4Glcα | ‐Glcα1‐4Glcα1‐4Glcα |
14 | 悬钩子七葡糖苷 | ‐Glcα1‐4Glcα1‐4Glcα | ‐Glcα1‐4Glcα |
15 | 悬钩子八葡糖苷 | ‐Glcα1‐4Glcα1‐4Glcα | ‐Glcα1‐4Glcα1‐4Glcα |
明显地,化合物1至15和/或甜叶悬钩子苷的混合物同样可用并属于本发明。因此优选实施方案是含有至少一个式(I)化合物的物质混合物,其选自式(II)的化合物:
·悬钩子三葡糖苷(化合物1)
·悬钩子三葡糖苷(化合物2)
·悬钩子四葡糖苷(化合物3)
·悬钩子四葡糖苷(化合物4)
·悬钩子四葡糖苷(化合物5)
·悬钩子五葡糖苷(化合物6)
·悬钩子五葡糖苷(化合物7)
·悬钩子六葡糖苷(化合物8)
·悬钩子五葡糖苷(化合物9)
·悬钩子五葡糖苷(化合物10)
·悬钩子六葡糖苷(化合物11)
·悬钩子六葡糖苷(化合物12)
·悬钩子七葡糖苷(化合物13)
·悬钩子七葡糖苷(化合物14)
·悬钩子八葡糖苷(化合物15)
优选地根据本发明的物质混合物含有至少一个式(I)的化合物(α‐葡糖基甜叶悬钩子苷),其中优选具备以下组成的根据本发明的物质混合物:
(a1)1重量%至60重量%,优选15重量%至50重量%的甜叶悬钩子苷(m+n=0),
(a2)1重量%至30重量,优选5重量%至25重量%的具备共3个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=1),
(a3)1重量%至30重量%,优选5重量%至25重量%的具备共4个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=2),
(a4)1重量%至25重量%,优选5重量%至20重量%的具备共5个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=3),
(a5)0.1重量%至20重量%,优选1重量%至15重量%的具备共6个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=4),
(a6)0.05重量%至10重量%,优选0.5重量%至5重量%的具备共5个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=5),
(a7)0重量%至10重量%,优选1重量%至8重量%的甜菊单苷或其异构体,其中一种或多种甜菊单苷‐异构体相对于甜叶悬钩子苷的存在比例为100:1至1:100,
(a8)以及1重量%至90重量%,优选20重量%至80重量%的具备5至50(m+n在3至48之间),优选6至16糖苷单元(m+n在4至14之间)的较高α‐葡糖基甜叶悬钩子苷,
其中所有成分(a1)至(a8)的总量至少为80重量%,优选至少90重量%。10至20重量%的剩余量通常由水、甘油、淀粉降解产物、蛋白质、脂肪酸和/或脂肪酸酯构成。
特别优选根据本发明的含有式(I)α‐葡糖基甜叶悬钩子苷的物质混合物,其具备以下组成:
(a1)少于50重量%的甜叶悬钩子苷(m+n=0),
(a2)多于10重量%的具备共3个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=1),
(a3)多于15重量%的具备共4个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=2),
(a4)多于5重量%的具备共5个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=3),
(a5)少于6重量%的甜菊单苷,
其中所有成分(a1)至(a5)的总量至少为80重量%,优选至少90重量%。10至20重量%的剩余量通常由水、甘油、淀粉降解产物、蛋白质、脂肪酸和/或脂肪酸酯构成。
特别优选的根据本发明的含有式(I)α‐葡糖基甜叶悬钩子苷的物质混合物,其具备以下组成:
(a1)少于30重量%的甜叶悬钩子苷(m+n=0),
(a2)多于15重量%的具备共3个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=1),
(a3)多于18重量%的具备共4个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=2),
(a4)多于10重量%的具备共5个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=3),
(a5)少于2.5重量%甜菊单苷,
其中所有成分(a1)至(a5)的总量至少为80重量%,优选至少90重量%。10至20重量%的剩余量通常由水、甘油、淀粉降解产物、蛋白质、脂肪酸和/或脂肪酸酯构成。
优选地,本发明的物质混合物具备式(I)化合物成分与额外淀粉降解产物的重量比为1:99至99:1,优选5:95至75:25,特别优选25:75至75:25,并且非常特别优选5:95至25:75。
根据本发明的物质混合物的优选组成包括例如:
(a)1重量%至99重量%,优选5重量%至50重量%α‐葡糖基甜叶悬钩子苷,
(b)0.1重量%至15重量%,优选0.5重量%至10重量%淀粉降解产物,
其中成分(a)和(b)的总量至少为80重量%,优选至少90重量%。10至20重量%的剩余量通常由水、甘油、淀粉降解产物、蛋白质、脂肪酸和/或脂肪酸酯构成。
当所述物质混合物额外含有增甜的天然产生的酚类香料物质时,根据本发明的物质混合物具备式(I)化合物成分和额外淀粉降解产物(a+b)与酚类香料物质(c)的重量比为1:99至99:1,优选10:90至90:10,特别优选25:75至75:25,并且非常特别优选40:60至60:40。
根据本发明的物质混合物的优选组成包括例如:
(a)20重量%至50重量%,优选27重量%至43重量%α‐葡糖基甜叶悬钩子苷,
(b)0.1重量%至15重量%,优选0.5重量%至10重量%麦芽糊精,和
(c)40重量%至60重量%,优选45重量%至55重量%酚类天然产生的增甜香料物质,其中成分(a),(b)和(c)的总量至少为80重量%,优选至少90重量%。10至20重量%的剩余量通常由水、甘油、淀粉降解产物、蛋白质、脂肪酸和/或脂肪酸酯构成。
制备
根据本发明的物质混合物,含有式(I)组合物(α‐葡糖基甜叶悬钩子苷),其理论上已知并可以根据例如Ohtani.K.;Aikawa.Y.;Ishikawa.H.;Kasai.R.;Kitahata.S.;Mizutani.K.;Doi.S.;Nakaura.M.;Tanaka.O..Further study on the 1.4‐alpha‐transglucosylation of rubusoside.a sweet steviol‐bisglucoside from Rubussuavissimus.Agric.Biol.Chem.1991.55.(2).449‐453制备,其中
i)将悬钩子苷与α‐葡聚糖,优选淀粉,淀粉降解产物或环糊精与糖苷酶,优选α‐糖苷酶如例如α‐淀粉酶、α‐糖苷酶、β‐淀粉酶、环麦芽糊精葡聚糖转移酶或适当的微生物,其同源或异源表达这些酶(例如黄单胞杆菌(Xantomonas campestris)、酿酒酵母(Saccharomyces cerevisiae)或肠膜明串珠菌(Leuconostoc mensenteroides))在0℃至90℃,优选5℃至80℃,特别优选20℃至65℃下,优选在含水介质中混合0至48小时,优选0.1至24小时,特别优选0.5‐16小时,并且
ii)将得到的混合物惰化、巴氏杀菌或消毒,其中将其在常压或加压下加热5至500分钟至70℃至150℃,并且
iii)随后干燥得到的混合物,使用例如喷雾干燥、冻干、蒸馏干燥、带式干燥和
iv)任选进一步纯化该混合,使用例如层析法、分配法、膜法或结晶法。
口服制剂
本发明的另一个主题涉及口服制剂,其含有0.00001重量%至约2重量%的根据本发明的物质混合物。优选地根据本发明的物质混合物的含量为0.0001重量%至1.5重量%,优选0.001重量%至1重量%,特别优选0.01重量%至0.5重量%,并且特别优选0.05重量%至0.1重量%。
食品
含有根据本发明的物质混合物的口服制剂可以选自组包括
·烘焙产品,例如面包、干饼干、蛋糕、其他烤制产品,
·糖果产品(例如巧克力、巧克力棒产品、其他棒状产品、水果糖、硬和软焦糖、口香糖),
·酒精或无酒精饮料(例如咖啡、茶、冰茶、红酒、含红酒饮料、啤酒、含啤酒饮料、利口酒、杜松子酒、白兰地、含水果(碳酸)柠檬水、(碳酸)等张饮料、(碳酸)软饮、花蜜、汽酒、水果和植物果汁,
·水果或植物果汁制品,
·速溶饮品(例如速溶可可饮料、速溶茶饮料、速溶咖啡饮料、速溶水果饮料),
·肉制品(例如火腿、鲜香肠或未烹制的香肠制品、风干或腌制鱼或腌肉产品),
·蛋或蛋产品(蛋粉、蛋白、蛋黄)、谷物产品(例如早餐谷物、麦片棒、现成米产品),
·乳产品(例如乳饮、酪乳饮料、乳品冰淇淋、酸奶、克菲尔、新鲜奶酪、软奶酪、硬奶酪、干奶粉、乳清、乳清饮料、黄油、酪乳、含有部分或完全水解乳蛋白的产品),
·大豆蛋白或其他大豆成分的制品(例如豆奶和由其制得的产品、含有大豆蛋白的水果饮料、含有大豆卵磷脂的制品、发酵产品如豆腐或豆豉或由其制得的产品),
·其他植物蛋白源产品,例如燕麦蛋白饮料,
·水果制品(例如果酱、水果冰淇淋、水果酱、水果馅料),
·蔬菜制品(例如番茄酱、沙司、干燥蔬菜、冷冻蔬菜、熟菜、瓶装蔬菜),
·小吃(例如烤制或炸制薯片或土豆团产品、玉米或花生挤出物),
·脂肪和油产品或乳剂(例如蛋黄酱、加料蛋黄酱、调味料),
·其他现成餐食和汤(例如汤粉、即食汤、预煮汤),
·香料、香料混合物以及特别是在小吃领域使用的调味料。
特别优选的是糖果制品、乳制品,并且特别优选无酒精饮料,其中优选甜味饮料。
助剂和添加剂
上述口服制剂和食品通常还可以含有助剂和添加剂,特别包括甜味剂、食品酸、酸度调节剂、增稠剂,以及特别是其他香料物质。
A1.甜味剂
作为甜味剂或甜味道的添加剂首先考虑的是碳水化合物并且特别是糖,如蔗糖、海藻糖、乳糖、麦芽糖、松三糖、蜜三糖、帕拉金糖、乳果糖、D‐果糖、D‐葡萄糖、D‐半乳糖、L‐鼠李糖、D‐山梨糖、D‐甘露糖、D‐塔格糖、D‐***糖、L‐***糖、D‐核糖、D‐甘油醛、或麦芽糊精。同样适用的是含有这些物质的植物化合物,例如基于甜菜(海甜菜(Beta vulgarisssp.)、糖馏分、糖浆、糖蜜)、甘蔗糖(甘蔗(Saccharum officinarum ssp.)、糖蜜、甘蔗糖浆)、枫糖浆(Acer ssp.)或龙舌兰属植物(龙舌兰糖浆)。
也可以考虑的是
·合成的,即通常的酶制淀粉或糖水解物(转化糖、果糖糖浆);
·浓缩果汁(例如基于苹果或梨);
·糖醇(例如赤藓糖醇、苏糖醇、***糖醇、核糖醇、木糖醇、山梨糖醇、甘露醇、半乳糖醇、乳糖醇);
·蛋白质(例如奇果蛋白(Miraculin)、甜蛋白(Monellin)、奇异果甜蛋白(Thaumatin)、仙茅甜蛋白(Curculin)、甜味蛋白(Brazzein));
·甜味剂(例如,Magap、环己氨基磺酸钠、乙酰磺胺酸钾、新橙皮苷二氢查耳酮、糖精钠、阿斯巴甜(Aspartam)、超阿斯巴甜、纽甜(Neotam)、阿力甜(Alitam)、三氯蔗糖(Sucralose)、甜菊苷(甜菊糖苷)、瑞鮑迪甙(Rebaudioside)、Lugduname、Carrelame、Sucrononate、Sucrooctate、Monatin、叶甜素(phenylodulcin));
·甜味道氨基酸(例如甘氨酸、D‐亮氨酸、D‐苏氨酸、D‐天门冬氨酸、D‐苯丙氨酸、D‐色氨酸、L‐脯氨酸);
·其他甜味道小分子物质,如例如甜菊糖苷元(Hernandulcin)、二氢查耳酮糖苷(Dihydrochalconglykoside),特别是新橙皮苷二氢查耳酮和甘草甜素(glycyrrhizin)、甘草甜酸(glycyrrhetic acid)、其衍生物和盐,甘草提取物(光果甘草(Glycyrrhizzaglabra ssp.))、甜舌草(Lippia dulcis)提取物、苦瓜(Momordica ssp.)提取物或
·单个物质如例如罗汉果及由其得到的罗汉果苷(Mogroside)、Hydrangeadulcis或叶甜素提取物,
·Mycetia balansae(南岭华腺)的Balansins,如记载于WO 2012 164.062。
A2.食品酸
适当的食品酸式羧酸。在本发明中优选食品中允许的酸,特别是此处提到的那些:
E 260‐醋酸
E 270‐乳酸
E 290‐二氧化碳
E 296‐苹果酸
E 297‐富马酸
E 330‐柠檬酸
E 331‐柠檬酸钠
E 332‐柠檬酸钾
E 333‐柠檬酸钙
E 334‐酒石酸
E 335‐酒石酸钠
E 336‐酒石酸钾
E 337‐酒石酸钠‐钾
E 338‐磷酸
E 353‐偏酒石酸
E 354‐酒石酸钙
E 355‐己二酸
E 363‐琥珀酸
E 380‐柠檬酸三铵
E 513‐硫酸
E 574‐葡糖酸
E 575‐葡萄糖酸‐δ‐内酯
A3.酸度调节剂
酸度调节剂是食品添加剂,其保持酸度或碱度并从而保持食品所需pH值的稳定。其通常涉及有机酸及其盐,碳酸盐,偶尔也涉及无机酸及其盐。加入酸味调节剂部分增强了食品的稳定性和强度,得到想要的沉淀并改善防腐剂的作用。与酸化剂相反酸度调节剂不用于食品味道的改变。其作用基于在食品中形成缓冲体系,因此加入酸性或碱性物质时pH值不改变或仅细微改变。实例是
E 170 ‐碳酸钙
E 260–263‐乙酸和乙酸盐
E 270 ‐乳酸
E 296 ‐苹果酸
E 297 ‐富马酸
E 325–327‐乳酸盐(乳酸)
E 330–333‐柠檬酸和柠檬酸盐
E 334–337‐酒石酸和酒石酸盐
E 339–341‐正磷酸盐
E 350–352‐苹果酸盐(苹果酸)
E 450–452‐二、三或多磷酸盐
E 500–504‐碳酸盐(碳酸)
E 507 ‐盐酸和氯化物
E 513–517‐硫酸和硫酸盐
E 524–528‐氢氧化物
E 529–530‐氧化物
E 355–357‐己二酸和己二酸盐
E 574–578‐葡糖酸和葡糖酸盐
A4.增稠剂
增稠剂是首先与水结合的物质。通过去除未结合的水可增大粘稠度。由对任何各种增稠剂有代表性的浓度起,还出现网络效果,这大多导致稠度不成比例的增大。在这种情况下分子相互之间“交联”,即缠绕。大多数增稠剂涉及线性或支化大分子(例如多糖或蛋白质),它们能够通过分子间相互作用,如氢键、疏水相互作用或离子作用相互作用。增稠剂的极端情况是层状硅酸盐(膨润土、水辉石)或水合SiO2颗粒,它们以颗粒分散并能够以其类固体结构与水结合,或者基于所述的相互作用能够相互作用。实例是:
E 400 –褐藻酸
E 401 –褐藻酸钠
E 402 ‐褐藻酸钾
E 403 –褐藻酸铵
E 404 –海藻酸钙
E 405 –褐藻酸丙二醇
E 406 –琼脂
E 407 –卡拉胶、丹麦琼脂
E 407 –刺槐豆胶
E 412 –瓜尔胶
E 413 –胺黄树胶
E 414 –***树胶
E 415 –黄原胶
E 416 –刺梧桐树胶(印度胺黄树胶)
E 417 –塔拉胶(秘鲁刺梧桐树胶)
E 418 –结冷胶
E 440 –果胶、Opekta
E 440ii –酰胺化果胶
E 460 ‐微晶纤维素、纤维素粉末
E 461 –甲基纤维素
E 462 –乙基纤维素
E 463 –羟丙基纤维素
E 465 –甲基乙基纤维素
E 466 –羧甲基纤维素、羧甲基纤维素钠
A6.香料物质
根据本发明的口服制剂和食品可以含有一种或多种香料物质。典型实施例包括:苯乙酮、己酸烯丙酯、α‐紫罗兰酮、β‐紫罗兰酮、茴香醛、乙酸茴香酯、甲酸茴香酯、苯甲醛、苯并噻唑、乙酸苄酯、苄醇、苯甲酸苄酯、β‐紫罗兰酮、丁酸丁酯、己酸丁酯、丁烯夫内酯、香芹酮、莰烯、丁香烯、桉油醇、乙酸肉桂酯、柠檬醛、香茅醇、香茅醛、乙酸香茅酯、乙酸环己酯、伞花烃、damascone、癸内酯、二氢香豆素、氨基苯甲酸二甲酯、十二内酯、乙酸乙氧基乙酯、乙基丁酸、丁酸乙酯、癸酸乙酯、己酸乙酯、巴豆酸乙酯、乙基呋喃酮、乙基愈创木酚、异丁酸乙酯、异戊酸乙酯、乳酸乙酯、甲基丁酸乙酯、丙酸乙酯、桉树脑、丁香油酚、庚酸乙酯、4‐(对‐羟苯基)‐2‐丁酮、γ‐癸内酯、香叶醇、乙酸香叶酯、柚子醛(grapefruit aldehyde)、二氢茉莉酮酸甲酯(例如)、胡椒醛、2‐庚酮、3‐庚酮、4‐庚酮、反式‐2‐庚稀醛、顺式‐4‐庚稀醛、反式‐2‐已烯醛、顺式‐3‐已烯醇、反式‐2‐己烯酸、反式‐3‐己烯酸、顺式‐2‐乙酸己烯酯、顺式‐3‐乙酸己烯酯、顺式‐3‐己酸己烯酯、反式‐2‐己酸己烯酯、顺式‐3‐甲酸己烯酯、顺式‐2‐乙酸己酯、顺式‐3‐乙酸己酯、反式‐2‐乙酸己酯、顺式‐3‐甲酸己酯、对‐羟基苄基丙酮、异戊醇、异戊酸异戊酯、丁酸异丁酯、异丁醛、异丁香油酚甲醚、异丙基甲基噻唑、月桂酸、乙酰丙酸、芳樟醇、芳樟醇氧化物、乙酸芳樟酯、薄荷醇、薄荷呋喃、氨基苯甲酸甲酯、甲基丁醇、甲基丁酸、乙酸2‐甲基丁酯、己酸甲酯、肉桂酸甲酯、5‐甲基糠醛、3,2,2‐甲基环戊烯醇、6,5,2‐甲基庚烯酮、二氢茉莉酮酸甲酯、茉莉酮酸甲酯、甲基丁酸2‐甲酯、2‐甲基‐2‐戊烯酸、硫代丁酸甲酯、3,1‐甲基硫代己醇、乙酸3‐甲基硫代己酯、橙花醇、乙酸橙花酯、反,反‐2,4‐壬二烯醛、2,4‐壬二烯醇、2,6‐壬二烯醇、香柏酮、δ‐辛内酯、γ‐辛内酯、2‐辛醇、3‐辛醇、1,3‐辛烯醇、乙酸1‐辛酯、乙酸3‐辛酯、棕榈酸、三聚乙醛、非兰烯、戊二酮、乙酸苯基乙酯、苯基乙基醇、异戊酸苯基乙酯、胡椒醛、丙醛、丁酸丙酯、蒲勒酮、蒲勒醇、甜橙醛、硫醇、松油稀、松油醇、异松油烯、8,3‐硫代薄荷酮、4,4,2‐硫代甲基戊酮、麝香草酚、δ‐十一内酯、γ‐十一内酯、valencene、戊酸、香草醛、3‐羟基丁酮、乙基香草醛、异丁酸乙基香草酯(=3‐乙氧基‐4‐异丁氧基苯甲醛)、2,5‐二甲基‐4‐羟基‐3(2H)‐呋喃酮及其衍生物(优选环高呋喃酮(=2‐乙基‐4‐羟基‐5‐甲基‐3(2H)‐呋喃酮))、高呋喃酮(=2‐乙基‐5‐甲基‐4‐羟基‐3(2H)‐呋喃酮和5‐乙基‐2‐甲基‐4‐羟基‐3(2H)‐呋喃酮)、麦芽酚和麦芽酚衍生物(优选乙基麦芽酚)、香豆素及其衍生物、γ‐内酯(优选γ‐十一内酯、γ‐壬内酯、γ‐癸内酯)、δ‐内酯(优选4‐甲基‐δ‐癸内酯、马索亚内酯、δ‐癸内酯、tuberolactone)、山梨酸甲酯、双香草醛、4‐羟基‐2(或5)‐乙基‐5(或2)‐甲基‐3(2H) 呋喃酮、2‐羟基‐3‐甲基‐2‐环戊烯酮、3‐羟基‐4,5‐二甲基‐2(5H)‐呋喃酮、乙酸异戊酯、丁酸乙酯、丁酸正丁酯、丁酸异戊酯、3‐甲基‐丁酸乙酯、正己酸乙酯、正己酸烯丙酯、正己酸正丁酯、正辛酸乙酯、3‐甲基‐3‐苯基代去水甘油酸乙酯、2‐反‐4‐顺‐癸二烯乙酯、4‐(对‐羟苯基)‐2‐丁酮、1,1‐二甲氧基‐2,2,5‐三甲基‐4‐己烷、2,6‐二甲基‐5‐庚烯‐1‐醛和苯基已烯醛、2‐甲基‐3‐(甲基硫代)呋喃、2‐甲基‐3‐呋喃硫醇、双(2‐甲基‐3‐呋喃基)二硫醚、糠硫醇、甲基硫代丙醛、2‐乙酰基‐2‐噻唑啉、3‐巯基‐2‐戊酮、2.5‐二甲基‐3‐呋喃硫醇、2,4,5‐三甲基噻唑、2‐乙酰基噻唑、2,4‐二甲基‐5‐乙基噻唑、2‐乙酰基‐1‐吡珞啉、2‐甲基‐3‐乙基吡嗪、2‐乙基‐3,5‐二甲基吡嗪、2‐乙基‐3,6‐二甲基吡嗪、2,3‐二乙基‐5‐甲基吡嗪、3‐异丙基‐2‐甲氧基吡嗪、3‐异丁基‐2‐甲氧基吡嗪、2‐乙酰基吡嗪、2‐戊基吡啶、(E.E)‐2,4‐癸二烯醛、(E,E)‐2,4‐壬二烯醛、(E)‐2‐辛烯醛、(E)‐2‐壬烯醛、2‐十一烯醛、12‐甲基十三醛、1‐戊烯‐3‐酮、4‐羟基‐2,5‐二甲基‐3(2H)‐呋喃酮、愈创木酚、3‐羟基‐4,5‐二甲基‐2(5H)‐呋喃酮、3‐羟基‐4‐甲基‐5‐乙基‐2(5H)‐呋喃酮、肉桂醛、肉桂醇、水杨酸甲酯、异蒲勒醇以及(不具体列出)这些物质的立体异构体、对映异构体、结构异构体、非对映异构体、顺式/反式‐异构体或差向异构体。
特别优选赋予牛奶‐奶油和充实味道感受的香料物质(如例如二乙酰、乙偶姻或γ‐内酯)以及赋予甜味‐焦糖味道感受并且辅助糖性能的香料物质(如例如麦芽酚、香草醛、苯甲醛、呋喃酮、胡椒醛)。
A7.用于遮蔽不良味道印象的香料物质
根据本发明的口服制剂和食品还可以含有其他香料物质,其可以减小或抑制制剂不良(苦、涩、干、粉、金属、钙质、白垩)的味道或后味,所谓的味道校正剂。所述味道校正剂选自例如下表:克替醇(lactisole)、克替醇酯,如EP 2,292,224中所记载,钠盐(例如氯化钠、乳酸钠、柠檬酸钠、乙酸钠、葡萄糖酸钠)、羟基黄酮类,优选圣草酚(Eriodictyol)、Sterubin(圣草酚‐7‐甲醚)、高圣草酚(Homoeriodictyol)、及其钠盐、钾盐、钙盐、镁盐或锌盐(特别是记载于EP 1258200 A2的那些,其中公开的相关化合物通过引用成为本申请的一部分)、二香草醛(divanillinen)(特别是记载于WO 2004/078302中的那些,其中公开的相关化合物通过引用成为本申请的一部分)和4‐羟基二氢查耳酮(优选US 2008/0227867A1中记载的那些,其中公开的相关化合物通过引用成为本申请的一部分),特别是根皮素(Phloretin)和二羟苯基羟基丙酮(Davidigenin)、WO 2008/046895A1和EP 1989944A1中记载的鲜味组合物、EP 2064959 A1、EP 2135516A1或EP 2135516 A1中记载的鲜味组合物,特别优选Rubemamin和Rubescenamin、香兰木脂素,特别优选落叶松树脂醇或罗汉松树脂酚,如WO 2012 146,584所记载、enterodiol,如DE 102 012,214,560所记载、烷酰胺,特别是墙草碱,如EP 2,058,297、EP 1,977,655‐B1和EP 2,008,530‐B1中所记载、以及N‐癸二酰烯基氨基酸.如EP 2,597,082中所记载,及其混合物。
口腔和牙齿护理物
在一个优选实施方案中口服制剂可以选自组包括口腔和牙齿护理物,其也包括漱口水和口香糖。
其具体实例是牙膏、牙胶、牙粉、漱口水等。牙膏或牙霜通常是指水的凝胶型或膏型制剂、增稠剂、保湿剂、磨料或清洗体、表面活性剂、甜味剂、香料物质、除臭活性成分以及抵抗口腔和牙齿疾病的活性成分。在根据本发明的牙膏中可以使用所有常规的清洗体,如白垩、磷酸氢钙、不溶性偏磷酸钠、硅酸铝、焦磷酸钙、细分散合成树脂、硅酸、氧化铝和三水合氧化铝。
优选地适用于根据本发明牙膏的清洗体是细分散硅酸干凝胶、硅酸水凝胶、硅酸沉淀、三水合氧化铝和细分散的α‐氧化铝或这些清洗体的混合物,用量为牙膏的15至40重量%。作为保湿剂,主要考虑的是用量至多为50重量%的低分子量聚乙二醇、甘油、山梨糖醇或这些产品的混合物。在已知增稠剂中,适用的是增稠细分散硅酸凝胶和水胶体,如例如羧甲基纤维素、羟乙基纤维素、羟丙基瓜尔胶、羟乙基淀粉、聚乙烯吡咯烷酮、高分子量聚乙二醇、植物胶如黄芪胶、琼脂、角叉菜胶、***树胶、黄原胶和羧乙烯基聚合物(例如类)。除了薄荷呋喃和薄荷醇化合物的混合物,口腔和牙齿护理物可以特别含有表面活性成分,优选阴离子和非离子高泡表面活性剂,如上述物质,但特别是烷基醚硫酸盐、烷基多苷及其混合物。
其他常规牙膏添加剂是:
·防腐剂和抗微生物物质,如对羟基苯甲酸甲酯、乙酯或丙酯、山梨酸钠、苯甲酸钠、溴氯苯酚、水杨酸苯酯、麝香草酚等;
·抗垢有效成分,例如有机磷酸酯如1‐羟基乙烷‐1,1‐二膦酸、1‐膦酸丙烷‐1,2,3‐三羧酸和由例如US 3,488,419、DE 2224430 A1和DE 2343196 A1已知的那些;
·其他抗龋齿物质如例如氟化钠、单氟磷酸钠、氟化锡;
·甜味剂,如例如糖精钠、环己氨基磺酸钠、蔗糖、乳糖、麦芽糖、果糖或(L‐天门冬氨酰‐L‐苯丙氨酸甲酯)、甜叶菊提取物或其甜味成分,特别是瑞鲍迪甙;
·其他香料,如例如桉树油、大茴香籽油、茴香油、枯茗油、乙酸甲酯、肉桂醛、茴香脑、香草醛、麝香草酚以及这些物质和其他天然和合成香料的混合物;
·颜料如二氧化钛;
·染料;
·缓冲物质如例如伯‐、仲‐或叔的碱金属磷酸盐、柠檬酸/柠檬酸钠;
·治愈伤口和消炎物质,如例如尿囊素、尿素、薁、洋甘菊活性成分和乙酰水杨酸衍生物。
化妆品制剂的优选实施方案是水性、糊状分散体形式的牙膏,含有抛光剂、保湿剂、粘度调节剂并且任选含有其他常规成分,以及用量为0.5至2重量%的薄荷呋喃和薄荷醇化合物的混合物。
在漱口水中可能含有精油、乳化剂、收敛爽肤药物提取物、牙垢抑制、抗菌添加剂和味道校正剂等的各种浓度梯度的水醇溶液的结合。本发明的其他优选实施方案是水性或水醇溶液形式的漱口水,含有用量为0.5至2重量%的薄荷呋喃和薄荷醇化合物的混合物。对于使用前稀释的漱口水,相对于目的稀释比例的更高浓度可以产生充足的效果。
此外为了改善流动性能,可以使用助溶剂,例如乙醇、异丙醇或多元醇;这些物质主要对应于上述载体。可以考虑的多元醇优选具有2至15个碳原子和至少两个羟基。多元醇可以含有其他官能团,特别是氨基或由氮改性。典型实施例是
·甘油;
·烷二醇,如例如乙二醇、二乙二醇、丙二醇、丁二醇、己二醇以及平均分子量100至1000道尔顿的聚乙二醇;
·自缩合度为1.5至10的技术低聚甘油混合物,如双甘油含量为40至50重量%的技术双甘油混合物;
·羟甲基化合物,如特别是三羟甲基乙烷、三羟甲基丙烷、三羟甲基丁烷、季戊四醇和二季戊四醇;
·低烷基糖苷,特别是烷基中含有1至8个碳原子的那些,如例如甲基和丁基糖苷;
·含有5至12个碳原子的糖醇,如例如山梨糖醇或甘露醇;
·含有5至12个碳原子的糖类,如例如葡萄糖或蔗糖;
·氨基糖,如例如葡糖胺;
·二醇胺,如二乙醇胺或2‐氨基‐1,3‐丙二醇。
适当的防腐剂是例如苯氧基乙醇、甲醛溶液、苯甲酸酯类、戊二醇或山梨酸,及其名称为的银复合物,以及列于化妆品法规附录6,部分A和B的其他物质。
可以提及的芳香油是天然芳香剂与合成芳香剂的混合物。天然芳香剂是花(百合、薰衣草、玫瑰、茉莉、橙花、依兰)、茎和叶(天竺葵、广藿香、苦橙)、果实(茴香、胡荽、香菜、杜松)、果皮(佛手柑、柠檬、橙)、根(肉豆蔻、当归、芹菜、小豆蔻、木香、鸢尾、菖蒲)、木材(松木、檀香、愈创木、雪松木、花梨木)、草本植物和禾本植物(龙蒿、柠檬草、鼠尾草、百里香)、松针和树枝(云杉、冷杉、松树、矮松)、树脂和香脂(格蓬、榄香脂、安息香、没药、乳香、红没药)的提取物。此外可以考虑动物原料,例如麝猫香和海狸香。典型的合成芳香剂化合物是酯、醚、醛、酮、醇和烃类产物。酯类芳香剂化合物是例如乙酸苄酯,异丁酸苯氧基乙酯、环己基乙酸p‐叔丁酯、乙酸芳樟酯、乙酸二甲基苄基原酯(dimethyl benzyl carbinylacetate)、乙酸苯乙酯、苯甲酸芳樟酯、甲酸苄酯、苯基甘氨酸乙基甲酯、环己基丙酸烯丙酯、丙酸苏合香酯和水杨酸苄酯。醚类包括,例如苄基乙基醚;醛类包括,例如含有8至18个碳原子的直链烷醛、柠檬醛、香茅醛、香茅基氧基乙醛、仙客来醛、羟基香茅醛、铃兰醛和波洁红醛;酮类包括例如紫罗兰酮、α‐异甲基紫罗酮和甲基柏木酮;醇类包括茴香脑、香茅醇、丁香酚、异丁香酚、香叶醇、芳樟醇、苯乙醇和松油醇;烃类主要包括萜烯类和香脂类。然而,优选使用各种芳香剂化合物的混合物,它们一起产生相应的香味。其它适当的芳香油为通常用作芳香成分的挥发性较低的精油,例如鼠尾草油、甘菊油、丁香油、蜂花油、薄荷油、肉桂叶油、莱姆花油、杜松子油、香根草油、乳香油、白松香油、岩蔷薇油和熏衣草油。以下为单独或以混合形式优选使用的物质:佛手柑油、二氢月桂烯醇、铃兰醛、新铃兰醛、香茅醇、苯乙醇、α‐己基肉桂醛、香叶醇、苄丙酮、仙客来醛、芳樟醇、乙氧基甲氧基环十一烷、龙涎呋喃、吲哚、二氢茉莉酮酸甲酯(hedione)、sandelice、柑橘类精油、柑橘油、橙油、乙醇酸烯丙基戊酯、cyclovertal、醒目熏衣草油、鼠尾草油、大马酮、波旁香叶油、水杨酸环己酯、Vertofix Coeur、Iso‐E‐Super、Fixolide NP、evernyl、iraldein gamma、苯乙酸、乙酸香叶酯、乙酸苄酯、玫瑰醚、romilllate、2‐乙基‐己酸乙酯(irotyl)和2‐叔丁基环己基乙基碳酸酯(floramat)。
例如薄荷油、留兰香油、大茴香籽油、八角茴香油、枯茗油、桉树油、小茴香油、柠檬油、冬青油、丁香油、薄荷醇等可以用作香料。
口香糖
当口服制剂是口香糖时,它们通常含有水不溶性成分和水溶性成分。
水不溶性底物,也已知为“胶基”通常含有天然或合成弹性体、树脂、脂肪和油体、塑化剂、填料、染料以及任选蜡。底物在总制剂中的比例通常为5至95重量%,优选10至50重量%并且特别是20至35重量%。在本发明的典型实施方案中底物由20至60重量%的合成弹性体、0至30重量%的天然弹性体、5至55重量%的塑化剂、4至35重量%的填料以及少量添加剂如染料、抗氧化剂等构成,前提是少量的它们在所有情况下是水溶性。
适当的合成弹性体是例如平均分子量(根据GPC)为10000至100000,优选50000至80000的聚异丁烯,异丁烯‐异戊二烯共聚物(“丁基弹性体”)、苯乙烯‐丁二烯共聚物(苯乙烯:丁二烯比例如1:3至3:1)、平均分子量(根据GPC)为2000至90000,并且优选10000至65000的聚乙烯乙酸酯、聚异戊二烯、聚乙烯、乙酸乙烯酯‐月桂酸乙烯酯共聚物及其混合物。适当的天然弹性体实例是橡胶,例如烟熏乳胶或液态乳胶或银胶菊以及天然橡胶如节路顿胶、lechi caspi、派里罗胶(perillo)、香豆果胶(sorva)、二齿铁线子木胶(massaranduba balata)、巧克力铁线子木胶(massaranduba chocolate)、红檀木胶(nispero)、柔星丁哈胶(rosindinha)、糖胶树胶、古塔胶(gutta hang kang)及其混合物。合成和天然弹性体的选择及其混合比例主要根据口香糖是否会产生气泡(“泡泡糖”)。优选地,使用含有节路顿胶、chicle、香豆果胶和铁线子木胶的弹性体混合物。
在大多数情况下,弹性体很难加工或充分控制,因此已经证明有利的是使用特定的塑化剂,其当然必须特别满足允许作为食品添加剂的所有要求。在这方面主要考虑树脂酸的酯,例如低脂肪醇或多元醇与完全或部分硬化的单体或低聚树脂酸的酯。为此特别使用甲基、甘油或季戊四醇酯及其混合物。或者,也可以考虑萜烯树脂,其源自α‐蒎烯、β‐蒎烯、δ‐柠檬烯或其混合物。
碳酸镁或碳酸钙、磨碎的泡沫岩、硅酸盐,特别是硅酸镁或硅酸铝、黏土、矾土、滑石粉、二氧化钛、磷酸单钙、二钙或三钙以及纤维素聚合物用作填料或增稠剂。
适当的乳化剂是牛脂、硬化牛脂、硬化或部分硬化植物油、可可脂、偏甘油酯、卵磷脂、三醋精和含有6至22,优选12至18个碳原子的饱和或未饱和脂肪酸,及其混合物。
可以考虑用作染料和漂白剂的是例如允许用于食物调色的FD和C型植物和水果提取物以及二氧化钛。
底物组合物可以含有蜡或不含蜡;不含蜡组合物的实例可见于专利文件US 5,286,500,其内容在此通过引用明确纳入。
除了水不溶性胶基,口香糖制剂通常含有水溶性成分,其例如由软化剂、甜味剂、填料、味觉物质、味道增强剂、乳化剂、染料、酸化剂、抗氧化剂等构成,前提是这些成分具备至少充分的水溶性。根据特定代表物质的水溶性,单一成分可以属于水不溶相或者水溶性相。然而,也可以使用例如水溶性乳化剂和水不溶性乳化剂的结合,其中单一代表物质位于不同相。通常,水不溶成分构成制剂的5至95重量%,并且优选约20至80重量%。
将水溶性软化剂或塑化剂加入口香糖组合物用于改善咀嚼性和咀嚼感受,并且在混合物中用量通常为0.5至15重量%。典型实例是甘油、卵磷脂以及山梨糖醇、硬化淀粉水解物或玉米糖浆的水溶液。
可以考虑含糖或不含糖化合物作为甜味剂,其用量为5至95重量%,优选20至80重量%,并且特别是30至60重量%,基于口香糖组合物计。典型的糖类甜味剂是蔗糖、葡萄糖、麦芽糖、糊精、转化糖粉、果糖、果糖、半乳糖、玉米糖浆及其混合物。可以考虑山梨糖醇、甘露醇、木糖醇、硬化淀粉水解物、麦芽糖醇及其混合物作为糖替代物。此外定义为高强度人造甜味剂(HIAS)的物质单独或者作为混合物也可以作为添加剂,如例如三氯蔗糖、阿斯巴甜、醋磺内酯盐、阿力甜、糖精和糖精盐、环己氨磺酸及其盐、甘草甜素、二氢查儿酮、索马甜、莫耐林甜蛋白等。
特别地,为了生产低卡路里口香糖,适当的填料是例如聚葡萄糖、低聚果糖(raftilose)、菊粉(raftilin)、寡聚果糖(NutraFlora)、帕拉金寡糖(palatinoseoligosaaccharides)、瓜尔胶水解产物(SunFiber)和糊精。
额外的味觉物质的选择实际上是无限的,并且对于本发明在本质上不是至关重要的。通常所有味觉物质的总含量为0.1至15重量%,优选为0.2至5重量%,基于口香糖组合物计。其它适合的味觉物质是例如精油,合成香料等,如例如大茴香籽油、八角油、枯茗油、桉树油、茴香油、柑桔油、冬青油、丁香油等也可以在口腔和牙齿护理物中使用。
此外口香糖可以含有其他适用于牙齿护理,尤其是适用于抵抗牙斑和牙龈炎的助剂和添加剂,如洗必泰、CPC或三氯生。此外,可以存在pH调节剂(例如缓冲剂或尿素)、抗龋齿活性物质(例如磷酸盐或氟化物)、生物活性成分(抗体、酶、咖啡因、植物提取物),只要这些物质允许用于食物,并且不会以不想要的方式相互反应。
工业应用
本发明的其他主题是本发明的物质混合物用于制备香料制剂的用途。由此制得的香料制剂特别有利地用于改善、增强或传递甜味和/或用于遮蔽例如甜味剂,优选苦、涩和/或类甜味剂(后)味道的不良味道印象。
因此本发明的另一个主题是本发明的物质混合物用于改善、增强或传递甜味和/或用于遮蔽例如甜味剂,优选苦、涩和/或类甜味剂(后)味道的不良味道印象的用途。
此外本发明的主题是一种香料制剂,含有上述根据本发明的物质混合物。
特别地本发明涉及口服制剂,含有根据本发明的物质混合物或根据本发明的香料组合物,其含有根据本发明的物质混合物。
此外本发明涉及一种改善、增强或传递甜味或遮蔽选自苦、涩和/或类甜味剂(后)味道的不良味道印象的方法,包括以下步骤:
a)提供一种甜味剂,其在口中产生不良味道印象,
b)提供根据权利要求1至10任一项所述的物质混合物,
c)将步骤a)和b)的成分混合。
本发明的另一主题是一种用于口服制剂味道优化的方法,其特征在于,使用0.0001重量%至2重量%的混合物,其含有成分
(a)悬钩子苷和/或α‐葡糖基甜叶悬钩子苷,
(b)淀粉降解产物,和
(c)任选一种或多种酚类天然产生的甜味增强香料物质,选自组包括橙皮素、根皮素、1‐(2,4‐二氢‐苯基)‐3‐(3‐羟基‐4‐甲氧基‐苯基)‐丙‐1‐酮、7,3‐二氢‐4′甲氧基黄烷和5‐羟基‐4‐(4‐羟基‐3‐甲氧基‐苯基)‐7‐甲氧基‐2‐苯并二氢吡喃酮。
最后本发明涉及物质混合物,含有
(a)悬钩子苷和/或α‐葡糖基甜叶悬钩子苷,
(b)淀粉降解产物,和
(c)任选一种或多种酚类天然产生的甜味增强香料物质,选自组包括橙皮素、根皮素、1‐(2,4‐二氢‐苯基)‐3‐(3‐羟基‐4‐甲氧基‐苯基)‐丙‐1‐酮、7,3‐二氢‐4′甲氧基黄烷和5‐羟基‐4‐(4‐羟基‐3‐甲氧基‐苯基)‐7‐甲氧基‐2‐苯并二氢吡喃酮
作为香料制剂用作口服制剂的用途。
对于混合物的优选组成,优选使用和加入量以及香料物质的性能参考上文。
本发明的另一个主题是一种改善、增强或传递甜味或遮蔽选自苦、涩和/或类甜味剂(后)味道的不良味道印象的方法,包括以下步骤:
a)提供一种甜味剂,其在口中产生不良味道印象,
b)提供根据权利要求1至10任一项所述的物质混合物,
c)将步骤a)和b)的成分混合。
实施例
实施例1
α‐葡糖基甜叶悬钩子苷的制备式实例
以1:1比例称取由土豆得到的麦芽糊精和含有70%甜叶悬钩子苷的黑莓叶提取物。随后加入0.1M磷酸钠缓冲液,在pH7下搅拌至所有成分完全溶解。通过在每g底物中加入1.4KNU‐CP环麦芽糊精葡聚糖转移酶开始反应。随后在轻微振荡下将该混合物在50℃下温育15h,10分钟内加热至80℃并随后冻干。借助LC‐MS和AF4分析混合物。
表1
用作香料制剂的物质混合物的组成,含有α‐葡糖基甜叶悬钩子苷和淀粉降解产物(以面积%计)
实施例2
香料制剂
将以下成分混合以制备相应的香料制剂
表2
香料制剂(以重量%计)
实施例3
饮料制剂
使用不同的根据本发明的物质混合物制备软饮并在20℃下将产品放置40h。随后由8名受训测试者组成的评定组在0(不存在)至10(显著表达)的线性标度上评价味道性能(描述符:初始甜味、甜味强度、糖味/充实味道感受)。组成和结果在下表3中总结。实施方案1和2为根据本发明,实施方案V1、V2和V3用于对比。实施方案C对应于标准,即未加香料的产品的味道评估。
表3
软饮制剂的味道性能(以重量%计)
糖减少的对比样C明显地评价最差。与之相反样品2最好。加入少量的橙皮素(V1)无法改善味道值。两个根据本发明的实施方案1和2相对于糖变体(C)表现出改善的初始甜味,提高的甜味强度和改进的糖味/充实味道感受。与样品V2相比实施方案1表现出更高的甜味强度和初始甜味以及改善的充实味道感受。α‐葡糖基甜叶悬钩子苷和(2)的结合与仅含α‐葡糖基甜叶悬钩子苷(1)以及含有甜叶悬钩子苷和橙皮素的变体相比可以增强甜味强度和充实味道感受。另一方面在根据本发明的实施方案(2)中橙皮素与α‐葡糖基甜叶悬钩子苷的结合与甜叶悬钩子苷和橙皮素的结合相比可以遮蔽类甜味剂或类酒精后味。
实施例4至9:
下文中本发明借助其他制剂实施例进行说明:
实施例4
清爽饮料(以重量%)
按给定的顺序混合组分并加水至100%。将混合物加入玻璃瓶并加入碳酸。
实施例5
硬焦糖(以重量%计)
内含物 | A | B | C | D |
糖 | 74.50 | ‐ | ‐ | ‐ |
M型帕拉金糖醇(Palatinit) | ‐ | 74.00 | 75.50 | 75.00 |
柠檬酸 | 0.5 | 1.0 | 0.5 | ‐ |
黄色色素 | ‐ | 0.01 | ‐ | ‐ |
红色色素 | ‐ | ‐ | 0.01 | ‐ |
蓝色色素 | 0.01 | ‐ | ‐ | 0.01 |
胡椒薄荷香料 | 0.1 | ‐ | ‐ | 0.1 |
柑橘香料 | ‐ | 0.1 | ‐ | ‐ |
红莓香料 | ‐ | ‐ | 0.1 | ‐ |
实施例1的含有麦芽糊精的物质混合物C | 0.01 | 0.012 | 0.015 | 0.008 |
Balansin A | ‐ | 0.005 | 0.010 | 0.005 |
橙皮素 | 0.001 | 0.0005 | ||
根皮素 | ‐ | 0.002 | ‐ | ‐ |
水 | 加至100 | 加至100 | 加至100 | 加至100 |
1)Pure Circle公司的甜菊糖苷/麦芽糊精混合物(80:20)
实施例6
低脂酸奶(以重量%计)
实施例7
水果口香糖(以重量%计)
实施例8
无糖口香糖(以重量%计)
实施例9
布丁(以g计)
Claims (14)
1.物质混合物,含有1重量%至60重量%的至少一种通式(I)化合物,其中m=n=0
和至少一种通式(I)的其他化合物,其中m或n≥1,前提是m和n相互独立地为0至50。
2.根据权利要求1所述的混合物,含有至少一种式(I)化合物,其中m和n相互独立地为0至50并且其和m+n>0,m+n≤50。
3.根据权利要求1或2所述的混合物,其中混合物额外含有淀粉降解产物。
4.根据权利要求3所述的混合物,其中淀粉降解产物含有3至100个α‐1‐4‐连接D‐吡喃型葡萄糖基。
5.根据权利要求1至4任一项所述的混合物,其中混合物额外含有一种或多种酚类天然产生的甜味增强香料物质,选自组包括橙皮素、根皮素、1‐(2,4‐二氢‐苯基)‐3‐(3‐羟基‐4‐甲氧基‐苯基)‐丙‐1‐酮和5‐羟基‐4‐(4‐羟基‐3‐甲氧基‐苯基)‐7‐甲氧基‐2‐苯并二氢吡喃酮。
6.根据权利要求1至5任一项所述的混合物,含有
(a1)1重量%至60重量%的甜叶悬钩子苷(m+n=0),
(a2)1重量%至30重量的具备共3个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=1),
(a3)1重量%至30重量%的具备共4个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=2),
(a4)1重量%至25重量%的具备共5个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=3),
(a5)0.1重量%至20重量%的具备共6个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=4),
(a6)0.05重量%至10重量%的具备共5个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=5),
(a7)0重量%至10重量%的甜菊单苷或其异构体,其中一种或多种甜菊单苷‐异构体相对于甜叶悬钩子苷的存在比例为100:1至1:100,
(a8)以及1重量%至90重量%的具备8至50(m+n在6至48之间)的高α‐葡糖基甜叶悬钩子苷.
其中所有成分(a1)至(a8)的总量至少为80重量%,并且剩余量通常由水、甘油、淀粉降解产物、蛋白质、脂肪酸和/或脂肪酸酯构成。
7.根据权利要求1至5任一项所述的混合物,含有
(a1)少于50重量%的甜叶悬钩子苷(m+n=0),
(a2)多于10重量%的具备共3个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=1),
(a3)多于15重量%的具备共4个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=2),
(a4)多于5重量%的具备共5个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=3),
(a5)少于6重量%的甜菊单苷,
其中所有成分(a1)至(a5)的总量至少为80重量%,并且剩余量通常由水、甘油、淀粉降解产物、蛋白质、脂肪酸和/或脂肪酸酯构成。
8.根据权利要求1至5任一项所述的混合物,含有
(a1)少于30重量%的甜叶悬钩子苷(m+n=0),
(a2)多于15重量%的具备共3个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=1),
(a3)多于18重量%的具备共4个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=2),
(a4)多于10重量%的具备共5个葡糖单元的α‐葡糖基甜叶悬钩子苷(m+n=3),
(a5)少于2.5重量%甜菊单苷,
其中所有成分(a1)至(a5)的总量至少为80重量%,并且剩余量通常由水、甘油、淀粉降解产物、蛋白质、脂肪酸和/或脂肪酸酯构成。
9.根据权利要求1至8任一项所述的混合物,其中存在至少一个式(I)的化合物具备m或n≥1,其选自组包括
·悬钩子三糖苷(化合物1),其中R1和R2分别为H‐和Glcα1‐,
·悬钩子三糖苷(化合物2),其中R1和R2分别为Glcα1‐和H‐,
·悬钩子四糖苷(化合物3),其中R1和R2为Glcα1‐,
·悬钩子四糖苷(化合物4),其中R1和R2分别为‐Glcα1‐4Glcα和H‐,
·悬钩子四糖苷(化合物5),其中R1和R2分别为H‐和‐Glcα1‐4Glcα,
·悬钩子五糖苷(化合物6),其中R1和R2分别为‐Glcα1‐4Glcα和Glcα1‐,
·悬钩子五糖苷(化合物7),其中R1和R2分别为Glcα1‐和‐Glcα1‐4Glcα,
·悬钩子六糖苷(化合物8),其中R1和R2为2‐Glcα1‐4Glcα,
·悬钩子五糖苷(化合物9),其中R1和R2分别为‐Glcα1‐4Glcα1‐4Glcα和H‐,
·悬钩子五糖苷(化合物10),其中R1和R2分别为H‐和‐Glcα1‐4Glcα1‐4Glcα,
·悬钩子六糖苷(化合物11),其中R1和R2分别为‐Glcα1‐4Glcα1‐4Glcα和Glcα1‐,
·悬钩子六糖苷(化合物12),其中R1和R2分别为Glcα1‐和‐Glcα1‐4Glcα1‐4Glcα,
·悬钩子七糖苷(化合物13),其中R1和R2分别为‐Glcα1‐4Glcα和‐Glcα1‐4Glcα1‐4Glcα,
·悬钩子七糖苷(化合物14),其中R1和R2分别为‐Glcα1‐4Glcα1‐4Glcα和‐Glcα1‐4Glcα,
·悬钩子八糖苷(化合物15),其中R1和R2为‐Glcα1‐4Glcα1‐4Glcα。
10.根据权利要求1至9任一项所述的混合物用于制备香料制剂的用途。
11.根据权利要求1至9任一项所述的混合物用于改善、增强或传递甜味和/或用于遮蔽例如甜味剂,优选苦、涩和/或类甜味剂(后)味道的不良味道印象。
12.香料制剂,含有根据权利要求1至9任一项所述的混合物。
13.口服制剂,含有根据权利要求1至9任一项所述的混合物或根据权利要求12所述的香料制剂。
14.用于制备根据权利要求1至9任一项所述的物质混合物中的悬钩子苷的方法,包括在1,4‐糖基化碳水化合物,优选为糖类的转糖基化反应中使用α‐环糊精葡聚糖转移酶,其中反应底物是黑莓叶提取物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14172306.4 | 2014-06-13 | ||
EP14172306.4A EP2954785B1 (de) | 2014-06-13 | 2014-06-13 | Neue Stoffmischung zur Verbesserung des Süssgeschmacks enthaltend Rubusosid oder alpha-Glycosylrubusosid |
PCT/EP2015/063092 WO2015189346A1 (de) | 2014-06-13 | 2015-06-11 | Neue stoffmischung zur verbesserung des süssgeschmacks enthaltend rubusosid oder alpha-glycosylrubusosid |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106459123A true CN106459123A (zh) | 2017-02-22 |
Family
ID=50976469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201580028334.2A Pending CN106459123A (zh) | 2014-06-13 | 2015-06-11 | 用于改善甜味的含有甜叶悬钩子苷或α‑葡糖基甜叶悬钩子苷的新型物质混合物 |
Country Status (4)
Country | Link |
---|---|
US (1) | US10538548B2 (zh) |
EP (1) | EP2954785B1 (zh) |
CN (1) | CN106459123A (zh) |
WO (1) | WO2015189346A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105685760A (zh) * | 2013-12-23 | 2016-06-22 | 国际香料和香精公司 | 转葡糖基化甜茶提取物及其制备方法与用途 |
CN110024934A (zh) * | 2019-05-20 | 2019-07-19 | 北京清和传家餐饮管理有限责任公司 | 一种鲅鱼馅料的除臭保鲜方法 |
CN112074527A (zh) * | 2018-09-29 | 2020-12-11 | 弗门尼舍有限公司 | 萜烯糖苷衍生物及其用途 |
CN113556944A (zh) * | 2019-03-05 | 2021-10-26 | 西姆莱斯有限公司 | 包含d-阿洛酮糖和味道修饰化合物的混合物 |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2688836T3 (es) * | 2014-09-23 | 2018-11-07 | ADM WILD Europe GmbH & Co. KG | Modificación enzimática de hojas de zarzamora dulce |
US11344051B2 (en) * | 2015-04-03 | 2022-05-31 | Dsm Ip Assets B.V. | Steviol glycosides |
KR20190021194A (ko) | 2016-04-28 | 2019-03-05 | 시므라이즈 아게 | 염증 상태에 영향을 미치는 신규 화합물 및 이들의 혼합물 |
EP3448174A1 (en) | 2016-04-28 | 2019-03-06 | Symrise AG | Use of 3-(3-hydroxy-4-methoxy-phenyl)-1-(2,4,6-trihydroxy-phenyl)-propan-1-one |
CN116035154A (zh) * | 2016-12-30 | 2023-05-02 | 红牛有限公司 | 甜味组合物 |
WO2019170222A1 (en) | 2018-03-06 | 2019-09-12 | Symrise Ag | Encapsulated active substance deposition on hairs and textile |
WO2019174713A1 (en) | 2018-03-12 | 2019-09-19 | Symrise Ag | Active substance adhesive film |
WO2019179597A1 (en) | 2018-03-19 | 2019-09-26 | Symrise Ag | Water-soluble release forms for an active substance |
BR112020021624B1 (pt) | 2018-04-24 | 2024-02-06 | Symrise Ag | Cápsulas núcleo-casca, produto, processo para produzir as referidas cápsulas e uso dos mesmos |
EP3823455A1 (de) | 2018-07-16 | 2021-05-26 | Symrise AG | Zusammensetzung zur substitution von zucker in backwaren |
US20220071933A1 (en) | 2019-01-18 | 2022-03-10 | Symrise Ag | Combination remedy |
WO2023066457A1 (en) | 2021-10-19 | 2023-04-27 | Symrise Ag | Rubusoside glucosides |
DE102022002848A1 (de) * | 2022-08-05 | 2024-02-08 | Carsten Norbert Johann Detzer | Verfahren zur Herstellung eines Funktionspapier |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002045145A (ja) * | 2000-08-03 | 2002-02-12 | Toyo Seito Kk | 甘味料組成物およびその製造方法 |
US20110189108A1 (en) * | 2010-02-01 | 2011-08-04 | Symrise Ag | Use of 1-(2,4-dihydroxy-phenyl)-3-(3-hydroxy-4-methoxy-phenyl)-propan-1-one |
US20110293538A1 (en) * | 2010-05-11 | 2011-12-01 | Symrise Ag | Use of rubusoside for reducing or suppressing certain unpleasant taste impressions |
WO2012112180A1 (en) * | 2011-02-17 | 2012-08-23 | Purecircle Usa | Glucosyl stevia composition |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL149701C (nl) | 1965-12-08 | 1981-05-15 | Procter & Gamble | Werkwijze voor het bereiden van een tegen tandsteen werkzaam tandverzorgingsmiddel, dat als werkzaam bestanddeel een fosfonzuurderivaat bevat, alsmede gevormd tandverzorgingsmiddel. |
DE2224430C3 (de) | 1972-05-19 | 1980-10-09 | Henkel Kgaa, 4000 Duesseldorf | Zahnsteinbildung verhindernde Mund- und Zahnpflegemittel |
DE2343196C3 (de) | 1973-08-27 | 1980-01-10 | Henkel Kgaa, 4000 Duesseldorf | Aiacycloalkan-2^-diphosphonsäuren oder deren wasserlösliche Salze |
US5286500A (en) | 1992-03-03 | 1994-02-15 | Wm. Wrigley Jr. Company | Wax-free chewing gum base |
DE10122898A1 (de) | 2001-05-11 | 2002-11-14 | Haarmann & Reimer Gmbh | Verwendung von Hydroxyflavanonen zur Maskierung des bitteren Geschmacks |
DE10310204A1 (de) | 2003-03-08 | 2004-09-16 | Symrise Gmbh & Co. Kg | Verwendung von Divanillin als Aromastoff |
BRPI0613854B1 (pt) * | 2005-07-27 | 2015-08-11 | Symrise Ag | Uso de hesperetina para reforçar o sabor doce, preparação e processo para reforçar sabor doce |
EP2079322A1 (en) | 2006-10-18 | 2009-07-22 | Symrise GmbH & Co. KG | Substituted bicycloý4.1.0¨heptane-7-carboxylic acid amides and derivatives thereof as food flavor substances |
US8778987B2 (en) | 2007-03-13 | 2014-07-15 | Symrise Ag | Use of 4-hydroxychalcone derivatives for masking an unpleasant taste |
EP1977655B1 (de) | 2007-03-29 | 2011-05-18 | Symrise AG | Aromakompositionen von Alkamiden mit Hesperetin und/oder 4-Hydroxydihydrochalkonen und deren Salzen zur Verstärkung süßer sensorischer Eindrücke |
EP1989944B1 (de) | 2007-05-08 | 2010-06-02 | Symrise GmbH & Co. KG | Substituierte Cyclopropancarbonsäure(3-methyl-cyclohexyl)amide als Geschmacksstoffe |
DE502008002360D1 (de) | 2007-06-19 | 2011-03-03 | Symrise Ag | Aromakomposition zum Verringern oder Unterdrücken von unerwünschtem bitteren und adstringierenden Eindruck |
EP2064959B1 (de) | 2007-10-31 | 2012-07-25 | Symrise AG | Aromatische Neo-Menthylamide als Geschmacksstoffe |
US8828469B2 (en) | 2007-11-08 | 2014-09-09 | Symrise Ag | Use of alkamides for masking an unpleasant flavor |
EP2135516B1 (de) | 2008-06-13 | 2012-08-15 | Symrise AG | Neo-Menthylderivate als Geschmacksstoffe |
DE102009016171A1 (de) | 2009-04-03 | 2010-10-07 | Plantextrakt Gmbh & Co. Kg | Verfahren zur Herstellung einer Extraktionssubstanz aus Blättern der süßen Brombeere und deren Verwendung |
DE102009027744A1 (de) | 2009-07-15 | 2011-01-20 | Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke | Prekursor-Verbindungen von Süßrezeptor-Antagonisten zur Prävention oder Behandlung von Krankheiten |
EP2517574B1 (de) | 2011-04-29 | 2015-11-11 | Symrise AG | Bestimmte Vanillyllignane und deren Verwendung als Geschmacksverbesserer |
EP2529632B1 (de) | 2011-05-31 | 2013-08-28 | Symrise AG | Zimtsäureamide als würzige Geschmacksstoffe |
EP2529633B1 (de) | 2011-06-01 | 2014-08-06 | Symrise AG | Oral konsumierbare Zubereitungen umfassend bestimmte süß schmeckende Triterpene und Triterpenglycoside |
ES2713573T3 (es) | 2011-06-20 | 2019-05-22 | Purecircle Usa Inc | Composición de estevia |
WO2013133689A1 (en) | 2012-03-08 | 2013-09-12 | Purecircle Sdn Bhd | High-purity rubusoside and process for producing of the same |
EP2570036B1 (de) * | 2011-09-15 | 2014-06-18 | Symrise AG | Verwendung bestimmter Neoflavonoide zur Verstärkung und/oder Erzeugung eines süßen sensorischen Eindruckes |
EP2570035B1 (de) * | 2011-09-15 | 2014-06-18 | Symrise AG | Verwendung von Neoflavonoiden zur Geschmacksmodifizierung |
EP2597082A1 (de) | 2011-11-24 | 2013-05-29 | Symrise AG | Verbindungen zur Maskierung eines unangenehmen Geschmacks |
DE102012214560A1 (de) | 2011-12-02 | 2013-06-06 | Symrise Ag | Bestimmte Lignane und deren Verwendung als Geschmacksverbesserer |
EP2641479A1 (en) | 2012-03-20 | 2013-09-25 | Rudolf Wild GmbH & Co. KG | Composition comprising an extract from sweet blackberry leaves |
-
2014
- 2014-06-13 EP EP14172306.4A patent/EP2954785B1/de active Active
-
2015
- 2015-06-11 US US15/313,724 patent/US10538548B2/en active Active
- 2015-06-11 WO PCT/EP2015/063092 patent/WO2015189346A1/de active Application Filing
- 2015-06-11 CN CN201580028334.2A patent/CN106459123A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002045145A (ja) * | 2000-08-03 | 2002-02-12 | Toyo Seito Kk | 甘味料組成物およびその製造方法 |
US20110189108A1 (en) * | 2010-02-01 | 2011-08-04 | Symrise Ag | Use of 1-(2,4-dihydroxy-phenyl)-3-(3-hydroxy-4-methoxy-phenyl)-propan-1-one |
US20110293538A1 (en) * | 2010-05-11 | 2011-12-01 | Symrise Ag | Use of rubusoside for reducing or suppressing certain unpleasant taste impressions |
WO2012112180A1 (en) * | 2011-02-17 | 2012-08-23 | Purecircle Usa | Glucosyl stevia composition |
Non-Patent Citations (4)
Title |
---|
KAZUHIRO OHTANI,等: "Further Study on the 1,4-α-Transglucosylation of Rubusoside, a Sweet Steviol-Bisglucoside from Rubus suavissimus", 《AGRICULTURAL AND BIOLOGICAL CHEMISTRY》 * |
KAZUHIRO OHTANI,等: "Solubilization of steviolbioside and steviolmonoside with γ-cyclodextrin and its application to selective syntheses of better sweet glycosides from stevioside and rubusoside", 《CHEMICAL & PHARMACEUTICAL BULLETIN》 * |
KENJI MIZUTANI,等: "Study on Improvement of Sweetness of Steviol Bisglycosides: Selective Enzymic Transglucosylation of the 13-O-Glycosyl Moiety", 《AGRICULTURAL AND BIOLOGICAL CHEMISTRY》 * |
MUCHSIN DARISE,等: "Enzymic Transglucosylation of Rubusoside and the Structure-Sweetness relationship of Steviol-Bisglycosides", 《AGRIC. BIOL. CHEM.》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105685760A (zh) * | 2013-12-23 | 2016-06-22 | 国际香料和香精公司 | 转葡糖基化甜茶提取物及其制备方法与用途 |
CN112074527A (zh) * | 2018-09-29 | 2020-12-11 | 弗门尼舍有限公司 | 萜烯糖苷衍生物及其用途 |
CN113556944A (zh) * | 2019-03-05 | 2021-10-26 | 西姆莱斯有限公司 | 包含d-阿洛酮糖和味道修饰化合物的混合物 |
CN110024934A (zh) * | 2019-05-20 | 2019-07-19 | 北京清和传家餐饮管理有限责任公司 | 一种鲅鱼馅料的除臭保鲜方法 |
Also Published As
Publication number | Publication date |
---|---|
EP2954785B1 (de) | 2018-06-06 |
WO2015189346A8 (de) | 2016-02-25 |
US10538548B2 (en) | 2020-01-21 |
US20170190727A1 (en) | 2017-07-06 |
WO2015189346A1 (de) | 2015-12-17 |
EP2954785A1 (de) | 2015-12-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN106459123A (zh) | 用于改善甜味的含有甜叶悬钩子苷或α‑葡糖基甜叶悬钩子苷的新型物质混合物 | |
JP7087145B2 (ja) | 経口摂取又は経口使用のためのステビオールグリコシド化合物、組成物、及びステビオールグリコシド溶解度を増強するための方法 | |
CN103781367B (zh) | 包含一些甜味三萜类和三萜甙类的口服制剂 | |
CN101247734B (zh) | 橙皮素用于增强甜味的用途 | |
CN105636453B (zh) | 物质混合物 | |
JP6998884B2 (ja) | 経口摂取または経口使用のためのステビオール配糖体組成物 | |
TWI603680B (zh) | Mixture of spice extract oral composition | |
CN101801177A (zh) | 甜味剂组合物 | |
EP2196098B1 (de) | In Cellulose inkudierte Aromastoffe | |
JP7003249B2 (ja) | 芳香組成物 | |
US9629795B2 (en) | Substance mixtures | |
EP2730178A1 (de) | Zubereitungen zur oralen Aufnahme | |
CN108366597A (zh) | 物质混合物 | |
CN103635096B (zh) | 被包封的酸、其制备方法及包括所述被包封的酸的咀嚼型胶基糖 | |
EP2883459B1 (de) | Zubereitungen zur oralen Aufnahme | |
EP2865372B1 (de) | Wirkstoffkapseln | |
EP2926673B1 (de) | Stoffgemische | |
KR101771811B1 (ko) | 초피나무 추출물에 의한 고감미도 감미료의 정미 개선제 | |
JP2010265215A (ja) | メチオニナーゼ阻害剤 | |
JP2019208503A (ja) | 酸味増強剤、及びそれを含有する酸成分含有組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170222 |
|
RJ01 | Rejection of invention patent application after publication |