CN106421945A - Full-automatic blood cell separation machine system - Google Patents

Full-automatic blood cell separation machine system Download PDF

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Publication number
CN106421945A
CN106421945A CN201610788102.3A CN201610788102A CN106421945A CN 106421945 A CN106421945 A CN 106421945A CN 201610788102 A CN201610788102 A CN 201610788102A CN 106421945 A CN106421945 A CN 106421945A
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China
Prior art keywords
bag
blood
blood cell
separation
separation bag
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CN201610788102.3A
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Chinese (zh)
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CN106421945B (en
Inventor
丁国良
路志浩
董国明
宋奎良
魏静
巩成
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SHANDONG ZHONGBAOKANG MEDICAL IMPLEMENTS CO Ltd
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SHANDONG ZHONGBAOKANG MEDICAL IMPLEMENTS CO Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02Blood transfusion apparatus
    • A61M1/0272Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02Blood transfusion apparatus
    • A61M1/0209Multiple bag systems for separating or storing blood components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B5/00Other centrifuges
    • B04B5/12Centrifuges in which rotors other than bowls generate centrifugal effects in stationary containers

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)

Abstract

The invention relates to a full-automatic blood cell separation machine system, and belongs to the technical field of medical blood collection and separation device. The full-automatic blood cell separation machine system comprises a centrifugal cylinder, wherein a rotor is arranged in the centrifugal cylinder, the rotor penetrates the bottom of the centrifugal cylinder to connect with a centrifugal drive device, and a blood separation device is arranged on the rotor. The full-automatic blood cell separation machine system is simple in structure, convenient in movement and wide in application range.

Description

Automatic blood cell seperator system
Technical field
The present invention relates to a kind of automatic blood cell seperator system, belong to medical treatment blood collection separation equipment technology neck Territory.
Background technology
Component blood infusion is a kind of effective measures of Modern medical therapy, uses more prevalent in recent years clinically.Become Dividing blood to include red blood cell, blood platelet and blood plasma, various component bloods are because preservation condition requires height, and the holding time is short, acquisition condition Require harsher.The acquisition mode of current component blood is divided into two kinds:Machine list is adopted and collected by hand.Machine list adopt be utilize into The automatic blood cell seperator of mouth is acquired, and purity is high, once can gather the component blood of single part or double part, but Being due to the simple donor's quantity contributing component blood seldom, and import equipment being expensive, a lot of blood stations limit because of condition, Cannot be equipped with, therefore component blood collecting quantity can not meet far away the Treatment need of clinic.And collected by hand mode efficiency is low, become Dividing blood purity and collection rate not high, the centrifuge being used for gathering is bulky, and the collection time limit of component blood requires higher, Qualified component blood just must can be prepared after collecting whole blood finishes, if exceeding time limit, red blood cell and blood in 4~6 hours The quality of slurry can not meet the requirement of relevant national standard, and based on the restriction of equipment and acquisition condition, the collection of component blood can only Carry out inside blood station.
Both the above acquisition mode is all only limitted to carry out inside blood station.And the supply more than 90% of China's blood used in clinic comes Coming from street corner voluntary blood donation, the equipment volume owing to being used for carrying out blood separation is excessively huge, it is impossible to be placed in blood-collecting car enterprising Promoting circulation of blood liquid separates, and major part blood exceeds the collection time limit of some component blood, causes the significant wastage of component blood, in turn results in and face The wretched insufficiency of bed component blood.
Content of the invention
It is an object of the invention to provide a kind of automatic blood cell seperator system, simple in construction, conveniently moving, Neng Gouying For blood-collecting car, it is ensured that the collection time limit of component blood.
Automatic blood cell seperator system of the present invention, including:Concentrator bowl, is provided with rotor, rotor in concentrator bowl Run through connection centrifugal driving device bottom concentrator bowl;Rotor is provided with blood separating mechanism.
Centrifugal driving device drives rotor to rotate, blood separating mechanism work on rotor, completes blood and separates.
Preferably, blood separating mechanism includes the first separator, and the first separator includes first being located on rotor Peristaltic pump, first peristaltic pump the first end connection whole blood bag outlet, first peristaltic pump the second end connection separation bag entrance, also include red Cell storage bag, red cell preservation bag entrance connection separation bag first exports;Rotor center be provided with blood accommodate storehouse, whole blood bag and Red cell preservation bag is placed in receiving storehouse;Rotor side is provided with plate assembly, and separation bag is placed in plate assembly.
Preferably, blood separating mechanism also includes the second separator, and the second separator includes collecting bag, and collecting bag enters Mouth is exported by second wriggling this connection separation bag second, collecting bag outlet blood plasma storage bag.
Preferably, separation bag first outlet is positioned at separation bag side, and corresponding separation bag first exports, and is provided with the in separation bag One blocking-up wall wall, the first blocking-up wall and separation bag side surround red blood cell transfer passage.
Preferably, the first blocking-up wall is that bending first blocks wall.
Preferably, separation bag entrance be positioned at separation bag first export with second outlet between, separation bag entrance and separation bag It is provided with the second blocking-up wall between second outlet.
Preferably, the separation bag sidewall and second of corresponding separation bag the second outlet side blocks between wall, and built-in inserted plate is arranged First training dyke.
Preferably, it is provided with the 3rd blocking-up wall between collecting bag entrance and exit.
Preferably, collecting bag sidewall and the 3rd of corresponding collecting bag outlet side blocks wall, and built-in inserted plate is provided with the second water conservancy diversion Dam.
Preferably, between collecting bag and blood plasma storage bag, the pipeline of connection connects transfering bag by three-way connection.
Preferably, blood separating mechanism is symmetrical arranged two groups.
Preferably, plate assembly includes outer plate and built-in inserted plate, and built-in inserted plate is provided with plug, outer plate is correspondingly arranged slotting Hole, outer plate both sides are provided with clamp, and corresponding clamp, rotor side arranges draw-in groove.
Compared with prior art, the invention has the beneficial effects as follows:
(1) by arranging rotor, the first peristaltic pump and the second peristaltic pump and separation bag and collecting bag, secondary centrifuging is carried out Action, it is achieved that being performed fully automatic of collecting whole blood blood platelet process, it is to avoid collected by hand possible pollution, safer, Collecting efficiency is high, decreases the manipulation strength of staff;
(2) equipment is simple, can be able to be used in blood-collecting car with onboard, it is ensured that gather the time limit, gathers behaviour Make more flexible;
(3) consumables cost is cheap, can be accepted by most of blood stations.
Brief description
Fig. 1 is the structural representation of one embodiment of the invention,
Fig. 2 is the top view of Fig. 1,
Fig. 3 is that in Fig. 2, in blood separation, blood flows to schematic diagram,
Fig. 4 is the structural representation of the plate assembly of one embodiment of the invention,
Fig. 5 is Fig. 4 centerboard assembly assembled state figure,
Fig. 6 is the first training dyke working state schematic representation in first time centrifugal action,
Fig. 7 is the second training dyke working state schematic representation in second time centrifugal action,
Fig. 8 is blood separation principle schematic diagram,
Fig. 9 is blood separation consumptive material schematic diagram,
Figure 10 is first time centrifugal action flow chart,
Figure 11 is second time centrifugal action flow chart.
In figure:11st, the 17th, upper cover the 13rd, concentrator bowl the 15th, rotor centrifuges motor and the 18th, fixes seat the 19th, adjustable bottom feet the 21st, The 23rd, red blood cell storehouse, blood plasma storehouse the 25th, the first peristaltic pump the 27th, cut pipe valve the 29th, plate assembly the 31st, whole blood storehouse the 32nd, second wriggle Pump the 33rd, collecting bag the 34th, the second training dyke the 35th, separation bag the 36th, the first training dyke the 37th, transfering bag the 39th, blood plasma storage bag 41st, whole blood bag the 43rd, red cell preservation bag the 53rd, three-way connection the 55th, flow-stopping clip;
29.1st, built-in inserted plate the 29.2nd, plug the 29.3rd, clamp the 29.4th, outer plate;
33.1st, collecting bag entrance the 33.2nd, collecting bag outlet the 33.3rd, the 3rd blocking-up wall;
35.1st, separation bag second exports the 35.2nd, separation bag entrance the 35.3rd, separation bag first and exports the 35.4th, the first blocking-up Wall the 35.5th, the second blocking-up wall;
39.1st, blood plasma storage bag entrance;
41.1st, whole blood bag outlet;
43.1st, red cell preservation bag entrance.
In Fig. 3, arrow represents whole blood and the flow direction of each component blood;
Arrow in Fig. 6 represents the flow direction of Platelet-rich plasm in first time centrifugal action;
Arrow in Fig. 7 represents the flow direction of poor thrombocyte plasma in the second centrifugal action,
Arrow in Fig. 8 represents whole blood and the flow direction of individual component blood.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete Describe, it is clear that described embodiment is only a part of embodiment of the present invention, rather than whole embodiments wholely.Based on Embodiment in the present invention, it is every other that those of ordinary skill in the art are obtained under the premise of not making creative work Embodiment, broadly falls into the scope of protection of the invention.
As shown in Fig. 1~Figure 11, automatic blood cell seperator system of the present invention, it is characterised in that include:From Heart cylinder 13, is provided with rotor 15 in concentrator bowl 13, rotor 15 runs through connection centrifugal driving device bottom concentrator bowl 13;Set on rotor 15 Having blood separating mechanism, concentrator bowl 13 upper buckle is closed lid 11, in the inner chamber that rotor 15 is positioned at concentrator bowl 13 and upper cover 11 surrounds. Centrifugal driving device is arranged on fixing seat 18, is provided with adjustable bottom feet 19 bottom fixing seat 18.Centrifugal driving device can for from Electrocardiograph 17.
Blood separating mechanism includes the first separator, and the first separator includes the first peristaltic pump being located on rotor 15 25, the first peristaltic pump 25 first end connection whole blood bag outlet 41.1, the first peristaltic pump 25 second end connection separation bag entrance 35.2, Also including red cell preservation bag 43, red cell preservation bag entrance 43.1 connects separation bag first and exports 35.3;Rotor 15 center sets Having blood to accommodate storehouse, whole blood bag 41 and red cell preservation bag 43 are placed in receiving storehouse;It is the 21st, red that receiving storehouse can be divided into blood plasma storehouse Cell storehouse 23 and whole blood storehouse 31;In the course of work, whole blood bag 41 is placed in whole blood storehouse 31, and blood plasma storage bag 39 is placed into blood plasma In storehouse 21, red cell preservation bag 43 is placed in red blood cell storehouse 23.
Rotor 15 side is provided with plate assembly 29, and separation bag 35 is placed in plate assembly 29.
Blood separating mechanism also includes the second separator, and the second separator includes collecting bag 33, collecting bag entrance 33.1 connect separation bag second by the second peristaltic pump 32 exports 35.1, collecting bag outlet 33.2 connection blood plasma storage bag entrance 39.1.Separation bag first exports 35.3 and is positioned at separation bag 35 side, and corresponding separation bag first exports 35.3, is provided with in separation bag 35 First blocking-up wall 35.4, the first blocking-up wall 35.4 and separation bag 35 side surround red blood cell transfer passage.First blocking-up wall 35.4 Block wall for bending first.Separation bag entrance 35.2 be positioned at separation bag first export 35.3 and separation bag second export 35.1 it Between, separation bag entrance 35.2 and separation bag second export and are provided with the second blocking-up wall 35.5 between 35.1.Corresponding separation bag second goes out Between separation bag 35 sidewall of mouth 35.1 sides and the second blocking-up wall 35.5, built-in inserted plate 29.1 arranges the first training dyke 36.Collect It is provided with the 3rd blocking-up wall 33.3 between bag entrance 33.1 and collecting bag outlet 33.2.The collecting bag of corresponding collecting bag outlet 33.2 sides 33 sidewalls and the 3rd blocking-up wall 33.3, built-in inserted plate 29.1 is provided with the second training dyke 34.Collecting bag 33 and blood plasma storage bag 39 it Between connection pipeline connect transfering bag 37 by three-way connection 53.
Blood separating mechanism is symmetrical arranged two groups.
Plate assembly 29 includes outer plate 29.4 and built-in inserted plate 29.1, and built-in inserted plate 29.1 is provided with plug 29.2, outer plate Being correspondingly arranged jack on 29.4, outer plate 29.4 both sides are provided with clamp 29.3, corresponding clamp 29.3, and rotor 15 side is arranged to be inserted Groove.Centrifugal driving device can be centrifugal motor 17.
Present configuration is simply light and handy, can be placed on car application, can be applied directly on blood-collecting car, can want In the time limit asked, whole blood is separated, it is ensured that the collection time limit of component blood.
Operation principle:
(1) centrifugal process gathers component blood:General principle is centrifugation technique.Produce when centrifugation technique is to utilize objects at high speed to rotate Raw powerful centrifugal force, makes the suspended particulate being placed in rotary body that sedimentation or floating to occur so that some particulate condensation or with Other particles separate.
(2) secondary centrifuging method gathers blood platelet:Blood is mainly made up of red blood cell, leucocyte, blood platelet and blood plasma, wherein Red blood cell, leucocyte and blood platelet etc. are suspended in blood plasma, and under the influence of centrifugal force, the different haemocyte of proportion can produce point Layer.
The course of work:
Whole blood is after centrifuging first, and heavy red blood cell can be affixed to outer layer, and then sinks, light specific gravity rich in blood platelet Blood plasma PRP can be affixed to internal layer, and then floats.In like manner, in second time centrifugal process, heavy blood platelet can be affixed to outer layer, The poor blood plasma PPP of light specific gravity can be affixed to internal layer.
As shown in Figure 10, centrifugal action for the first time:
(1) opening all of flow-stopping clip 55, the flow-stopping clip 55 on transfering bag 37 is closed, and starts centrifugal motor 17, centrifugal Motor 17 starts running;After reaching requirement rotating speed, cut a pipe valve 27 open, then the first peristaltic pump 25 starts running, by whole blood from Whole blood bag 41 is pumped in separation bag 35;
(2) under the influence of centrifugal force, whole blood is first radially layered along centrifugal motor 17, internal layer be proportion little rich in Thrombocyte plasma PRP, outer layer is heavy leucocyte and red blood cell;
(3) under the continuation effect of centrifugal force, red blood cell sinks along outer layer, logical along the red blood cell conveying below separation bag 35 Road enters in red cell preservation bag 43;
As shown in figure 11, centrifugal action for the second time:
(4) Platelet-rich plasm PRP, under the effect of the second peristaltic pump 32, enters below the first training dyke 36 simultaneously In collecting bag 33, the second blocking-up wall 35.5 and the first training dyke 36 can prevent whole blood and red blood cell to be mixed into rich in blood platelet blood In slurry PRP;
(5) enter into the Platelet-rich plasm PRP in collecting bag 33, be layered under the influence of centrifugal force, internal layer For the little poor thrombocyte plasma PPP of proportion, outer layer is heavy blood platelet;
(6) under the continuation effect of centrifugal force, blood platelet sinks along outer layer, and poor thrombocyte plasma PPP is flowed into along pipeline In blood plasma storage bag 39;
Wherein transfering bag 37 uses for follow-up preparation cryoprecipitate;After preparation terminates, close all flow-stopping clips 55, take out once Property consumptive material, separation terminates.
As it is shown in figure 9, medical disposable material includes whole blood bag 41, red cell preservation bag 43, blood plasma storage bag 39, transfering bag 37, collecting bag 33, separation bag, connecting pipeline, flow-stopping clip, and it is located at whole blood bag the 41st, red cell preservation bag the 43rd, blood plasma storage bag 39th, the interface of transfering bag the 37th, collecting bag the 33rd, separation bag 35 entrance and exit.
Term is explained:PPP refers to poor thrombocyte plasma, and PRP refers to Platelet-rich plasm.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention Within god and principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Description to the direction of structure and relative position relation in the present invention, such as description upper and lower all around, not structure Become limitation of the present invention, only for convenience of description.

Claims (12)

1. an automatic blood cell seperator system, it is characterised in that include:Concentrator bowl (13), concentrator bowl is provided with in (13) Rotor (15), rotor (15) runs through concentrator bowl (13) bottom and connects centrifugal driving device;Rotor (15) is provided with blood and separates dress Put.
2. automatic blood cell seperator system according to claim 1, it is characterised in that blood separating mechanism includes One separator, the first separator includes the first peristaltic pump (25) being located on rotor (15), the first peristaltic pump (25) first End connection whole blood bag outlet (41.1), the first peristaltic pump (25) second end connection separation bag entrance (35.2), also include red blood cell Storage bag (43), red cell preservation bag entrance (43.1) connection separation bag first exports (35.3);Rotor (15) center is provided with blood Liquid accommodates storehouse, and whole blood bag (41) and red cell preservation bag (43) are placed in receiving storehouse;Rotor (15) side is provided with plate assembly (29), separation bag (35) is placed in plate assembly (29).
3. automatic blood cell seperator system according to claim 2, it is characterised in that blood separating mechanism also includes Second separator, the second separator includes collecting bag (33), and collecting bag entrance (33.1) is by the second peristaltic pump (32) even Logical separation bag second exports (35.1), collecting bag outlet (33.2) connection blood plasma storage bag entrance (39.1).
4. automatic blood cell seperator system according to claim 2, it is characterised in that separation bag first exports (35.3) being positioned at separation bag (35) side, corresponding separation bag first exports (35.3), is provided with the first blocking-up wall in separation bag (35) (35.4), the first blocking-up wall (35.4) and separation bag (35) side surround red blood cell transfer passage.
5. automatic blood cell seperator system according to claim 4, it is characterised in that the first blocking-up wall (35.4) is Bending first blocks wall.
6. automatic blood cell seperator system according to claim 3, it is characterised in that separation bag entrance (35.2) position Export (35.3) in separation bag first and separation bag second exports between (35.1), separation bag entrance (35.2) and separation bag second It is provided with the second blocking-up wall (35.5) between outlet (35.1).
7. automatic blood cell seperator system according to claim 6, it is characterised in that corresponding separation bag second exports (35.1) separation bag (35) sidewall and second of side blocks between wall (35.5), and built-in inserted plate arranges the first training dyke on (29.1) (36).
8. automatic blood cell seperator system according to claim 3, it is characterised in that collecting bag entrance (33.1) and It is provided with the 3rd blocking-up wall (33.3) between collecting bag outlet (33.2).
9. automatic blood cell seperator system according to claim 8, it is characterised in that corresponding collecting bag outlet (33.2) collecting bag (33) sidewall and the 3rd of side blocks wall (33.3), and built-in inserted plate (29.1) is provided with the second training dyke (34).
10. automatic blood cell seperator system according to claim 3, it is characterised in that collecting bag (33) and blood plasma The pipeline of connection between storage bag (39) is by three-way connection (53) connection transfering bag (37).
11. automatic blood cell seperator systems according to claim 1, it is characterised in that blood separating mechanism is symmetrical Arrange two groups.
12. automatic blood cell seperator systems according to claim 2, it is characterised in that plate assembly (29) includes Outer plate (29.4) and built-in inserted plate (29.1), built-in inserted plate (29.1) is provided with plug (29.2), and the upper correspondence of outer plate (29.4) sets Putting jack, outer plate (29.4) both sides are provided with clamp (29.3), and corresponding clamp (29.3) rotor (15) side arranges draw-in groove.
CN201610788102.3A 2016-08-31 2016-08-31 Automatic blood cell seperator system Active CN106421945B (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114110258A (en) * 2021-11-19 2022-03-01 山东中保康医疗器具有限公司 Blood pipeline attitude control device and blood separator with same
CN114289194A (en) * 2021-12-30 2022-04-08 昕慕(江苏)生物医药科技有限公司 Blood component separator and use method

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CN206372330U (en) * 2016-08-31 2017-08-04 山东中保康医疗器具有限公司 Automatic blood cell seperator system

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US4146172A (en) * 1977-10-18 1979-03-27 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing system
US5154716A (en) * 1990-11-06 1992-10-13 Miles Inc. Bottom blood bag separation system
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Publication number Priority date Publication date Assignee Title
CN114110258A (en) * 2021-11-19 2022-03-01 山东中保康医疗器具有限公司 Blood pipeline attitude control device and blood separator with same
CN114289194A (en) * 2021-12-30 2022-04-08 昕慕(江苏)生物医药科技有限公司 Blood component separator and use method

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