CN106421763A - Alimentary canal de-foaming agent - Google Patents
Alimentary canal de-foaming agent Download PDFInfo
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- CN106421763A CN106421763A CN201610937294.XA CN201610937294A CN106421763A CN 106421763 A CN106421763 A CN 106421763A CN 201610937294 A CN201610937294 A CN 201610937294A CN 106421763 A CN106421763 A CN 106421763A
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- infusion
- digestive tract
- weight portion
- dispelled
- excipient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
The invention aims to provide an alimentary canal de-foaming agent which comprises acid protease, pepper extractive, cuttlebone and excipients, wherein the optimal pH value of the acid protease is 1.0-5.5. The invention also discloses a preparation method for the alimentary canal de-foaming agent. The alimentary canal de-foaming agent has the beneficial effects that the cuttlebone can reduce the tension of local surface of the foam, damage the self-healing effect of the foam, break the foam, increase the definition of endoscopy and avoid the error of an inspection result; the pepper extractive is taken as a local anesthetic, has a better anesthetic effect, is capable of reversibly blocking the impulse conduction of the nerve trunk and reducing the excitability of the nerve trunk, and can relieve the pain of a patient in an endoscopy process; and the pepper extractive and the cuttlebone are combined for preparing the alimentary canal de-foaming agent, so that the degradation rate of the foam can be increased and the generation of the foam can be restrained.
Description
Technical field
The invention belongs to pharmaceutical technology field, especially relate to a kind of digestive tract and dispel infusion, for digestive endoscopy
With adjuvant drug before treatment or imaging examination.
Background technology
Digestive endoscopy refers to look at a kind of tubulose of gastrointestinal tract and abdominal visceral browser pathological changes under light is illuminated straight
Instrumental examination, the diagnosis for obtaining through other inspection methods can be both finally confirmed, can also make to be difficult to make a definite diagnosis through additive method
Early lesion made a definite diagnosis, particularly swollen to early gastrointestinal carcinoma discovery plays the role of uniqueness.But during diagnosis,
Due to there is a large amount of foams and mucus in digestive tract, cause the visual field unclear, the review time is long, increase patient suffering, and easily
Cause mistaken diagnosis and fail to pinpoint a disease in diagnosis, be also unfavorable for early diagnosiss and the discovery of digestive tract disease.
The digestive tract of prior art is dispelled more than infusion and is hydrolyzed mucus water using pepsin, trypsin or chain protease,
And simethicone is added as defoamer, to eliminate the mucus in digestive system and foam.Pepsin (English name：
Pepsin it is) a kind of digestible protein enzyme, secreted by the gastric chief cells (gastric chief cell) in stomach, work(
It is little fragments of peptides by the breaks down proteins in food that can be.Trypsin Trypsin (Parenzyme) is the one of protease
Kind, it is a kind of serine protein hydrolase for extracting from the pancreas of cattle, sheep, pig, only fracture lysine or arginine participate in being formed
Peptide bond, pH be 8.0, temperature be 37 DEG C when, the ability to function of trypsin solution is most strong.Chain protease be from streptococcus
A kind of serinase being separated in (Streptomyces griseus) and the mixture of acid protease.
Content of the invention
It is an object of the invention to provide a kind of stability height, can normal temperature storage, the holding time is long, and the removal of foam effect is good
Digestive tract is dispelled infusion
The technical scheme is that：
A kind of digestive tract is dispelled infusion, including acid protease, Fructus Zanthoxyli extract, Endoconcha Sepiae and excipient, acid protease
Optimum pH be 1.0-5.5.
Acid protease be a kind of can be in the enzyme of aminosal under sour environment.
The present invention hydrolyzes digestive tract mucus using acid protease, can be directed to the feature of digestive tract mucus, in acid bar
Many peptide bonds containing serine are targetedly hydrolyzed under part, and hydrolysis time is short, and effect is good.Can be by digestive tract within 5 minutes
Interior foam hydrolysis is complete.
The Endoconcha Sepiae, Chinese medicine name.For Sepiidae animal sepiella maindroni de Rochebrune Sepiella maindroni deRoehebrune
Or golden cuttlefish Sepia esculenta Hoyle dry inner shell.It is distributed in the ground such as Zhejiang, Fujian, Shandong.Stop with convergence
Blood, relieving leukorrhea by astringents, relieving gastric hyperacidity to alleviate stomachache, the effect of removing dampness sore.It is usually used in hematemesis and epistaxiss, metrorrhagia is had blood in stool, emission and spermatorrhea, red and white leukorrhea
Under, acid regurgitation of having a stomachache；External treatment bleeding due to trauma, eczema eczema, ulcer being unable to heal.Endoconcha Sepiae used by the present invention is irregular transparent sheet,
Tool stria, surface shows network structure, and the present invention adds Endoconcha Sepiae powder in infusion of dispelling, and can expand in the foam of stomach
Dissipate, during diffusion, in foam wall, duplicature is formed, the tension force of foam local surfaces can be reduced in this diffusion process, destroy bubble
The spontaneous recovery effect of foam, makes lather collapse, and Endoconcha Sepiae granule can also enter foam wall, foam is punctured, and improves the clear of endoscopy
Clear degree, it is to avoid inspection result goes wrong.
The Fructus Zanthoxyli extract is extracted for the peel of rutaceae Pericarpium Zanthoxyli Zanthoxylum bungeanum Maxim.
Thing, is brown ceramic powder, and taste is micro- sour, bitter, puckery, have draw moist.Warm in nature, acrid in the mouth.Warming middle-JIAO to relieve pain, killing parasites for relieving itching.For coldness and pain in the epigastrium,
Vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis；External treatment eczema itch.Fructus Zanthoxyli extract is applied to stomach can be had as local anesthetic
There is stronger anesthetic action, reversibly the dry conduction of impulse of block nerves and reduction nerve trunk irritability, reduce including patient
Pain during spectroscopy.Research worker of the present invention also finds to combine for digestive tract Fructus Zanthoxyli extract with Endoconcha Sepiae under study for action
Infusion of dispelling is not only able to improve the degradation rate of foam, additionally it is possible to suppress the generation of foam.
The excipient includes pH adjusting agent, and the pH adjusting agent is the one kind in carbonate, phosphate or borate
Or it is several.
In order to the acidity environment in digestive tract is further safeguarded, pH adjusting agent can be added in excipient.
Also include stabilizer in the excipient, the stabilizer is cyclodextrin and/or poloxamer.
Cyclodextrin and poloxamer are respectively macromolecular compound, can be by protease inclusion in cyclodextrin or pool Lip river sand
The center of nurse, is reduced protease and is exposed in external environment condition, while cyclodextrin and can also be combined with the active center of protease, make
The peptide chain of protease is firmly combined together by the activated three dimensional structure spatial stability of protease, strengthens stablizing for protease
Property, enables digestive tract infusion of dispelling to store under normal temperature condition, without the need for cryogenic storage facilities such as refrigerators, is very easy to practicality
Property, reduce use cost.
Digestive tract infusion of dispelling includes acid protease 20-30 weight portion, Fructus Zanthoxyli extract 5-15 weight portion, Endoconcha Sepiae
5-10 weight portion and excipient 40-80 weight portion.
Digestive tract infusion of dispelling includes acid protease 20-30 weight portion, Fructus Zanthoxyli extract 5-10 weight portion, Endoconcha Sepiae
5-8 weight portion and excipient 40-70 weight portion.
The granularity of the Endoconcha Sepiae is 100-800 mesh.
The granularity of the Endoconcha Sepiae is 300-500 mesh.
Research worker of the present invention find using granularity for 300-500 mesh Endoconcha Sepiae when, the removal of foam effect is best.
A kind of digestive tract is dispelled the preparation method of infusion, comprises the following steps：
(1) 100 mesh sieves are crossed load weighted acid protease, Fructus Zanthoxyli extract, Endoconcha Sepiae and excipient, mixes 15- afterwards
30min；
(2) mass concentration for adding acid protease, Pericarpium Zanthoxyli, Endoconcha Sepiae and excipient gross weight 5-15% weight portion is
50% alcoholic solution, continues mixing 20-50min；
(3) acid protease for mixing, Pericarpium Zanthoxyli, Endoconcha Sepiae and excipient are dry 20- under the conditions of 30-65 DEG C
60mim, obtains digestive tract and dispels infusion.
The preparation method process is simple, protease need not carry out physical separation using modes such as parcels with unclassified stores,
The protease that the digestive tract of the present invention is dispelled in infusion is directly mixed with unclassified stores, can simplify production technology and stream
Journey, reduces production cost.
The digestive tract of the present invention is dispelled infusion, and protease can effectively decompose the mucus in digestive tract, reduces because mucus exists
The generation of foam in digestive tract, therefore avoids the need for the flushing to mucus spume in digestive tract using traditional defoamer, can
Simplify endoscope diagnosis and treatment operating process, improve the definition in the visual field during endoscope diagnosis and treatment.
Specific embodiment
Embodiment 1
By 40 weight portion of acid protease, 30 weight portion of Fructus Zanthoxyli extract, 5 weight portion of Endoconcha Sepiae and 100 weight of excipient
Part mixes 15min after crossing 100 mesh sieves；Add the matter of acid protease, Pericarpium Zanthoxyli, Endoconcha Sepiae and 15% weight portion of excipient gross weight
Amount concentration is 50% alcoholic solution, continues mixing 50min；By the acid protease for mixing, Pericarpium Zanthoxyli, Endoconcha Sepiae and excipient
Dry 20mim under the conditions of 65 DEG C, obtain digestive tract and dispel infusion.
Embodiment 2
By 10 weight portion of acid protease, 5 weight portion of Fructus Zanthoxyli extract, 5 weight portion of Endoconcha Sepiae and 80 weight portion of excipient
100 mesh sieves are crossed, mixes 30min afterwards；Add the quality of acid protease, Pericarpium Zanthoxyli, Endoconcha Sepiae and 5% weight portion of excipient gross weight
Concentration is 50% alcoholic solution, continues mixing 30min；The acid protease for mixing, Pericarpium Zanthoxyli, Endoconcha Sepiae and excipient are existed
Dry 60mim under the conditions of 30 DEG C, obtain digestive tract and dispel infusion.
Embodiment 3
By 20 weight portion of acid protease, 15 weight portion of Fructus Zanthoxyli extract, 10 weight portion of Endoconcha Sepiae and 40 weight of excipient
Part crosses 100 mesh sieves, mixes 30min afterwards；Add acid protease, Pericarpium Zanthoxyli, Endoconcha Sepiae and 15% weight portion of excipient gross weight
Mass concentration is 50% alcoholic solution, continues mixing 50min；By the acid protease for mixing, Pericarpium Zanthoxyli, Endoconcha Sepiae and figuration
Agent dries 30mim under the conditions of 65 DEG C, obtains digestive tract and dispels infusion.
Embodiment 4
By 30 weight portion of acid protease, 10 weight portion of Fructus Zanthoxyli extract, 8 weight portion of Endoconcha Sepiae and 60 weight portion of excipient
100 mesh sieves are crossed, mixes 30min afterwards；Add the matter of acid protease, Pericarpium Zanthoxyli, Endoconcha Sepiae and 10% weight portion of excipient gross weight
Amount concentration is 50% alcoholic solution, continues mixing 30min；By the acid protease for mixing, Pericarpium Zanthoxyli, Endoconcha Sepiae and excipient
Dry 60mim under the conditions of 55 DEG C, obtain digestive tract and dispel infusion.
Embodiment 5
By 25 weight portion of acid protease, 10 weight portion of Fructus Zanthoxyli extract, 5 weight portion of Endoconcha Sepiae and 20 weight portion of excipient
100 mesh sieves are crossed, mixes 30min afterwards；Add the quality of acid protease, Pericarpium Zanthoxyli, Endoconcha Sepiae and 5% weight portion of excipient gross weight
Concentration is 50% alcoholic solution, continues mixing 50min；The acid protease for mixing, Pericarpium Zanthoxyli, Endoconcha Sepiae and excipient are existed
Dry 30mim under the conditions of 60 DEG C, obtain digestive tract and dispel infusion.1 hydrolysis rate of experimental example is tested
Test group：Embodiment 1 prepares digestive tract and dispels infusion
Matched group：The high definition scope for preparing according to 201210504348.5 embodiment of application for a patent for invention number 1 goes mucus to disappear
Bubble compound formulation
Experiment material：Mucin
Time：5min、10min、15min、30min、60min
1 different time experimental group of table and matched group are to mucinous degradation rate
| 5min | 10min | 15min | 30min | 60min | |
| Test group | 72% | 89% | 100% | 100% | 100% |
| Matched group | 18% | 31% | 42% | 58% | 73% |
Test result indicate that：Experimental group is to mucinous drop within the time of 5min, 10min, 15min, 30min, 60min
Solution rate is respectively higher than matched group.Therefore the present invention provide enteral digestion road dispel infusion to mucinous degraded have obviously
Advantage, degradation rate is very fast.
Above embodiments of the invention are described in detail, but the content have been only presently preferred embodiments of the present invention,
The practical range being not to be regarded as limiting the present invention.All impartial changes that is made according to the present patent application scope and improvement etc.,
Still all should belong within the patent covering scope of the present invention.
Claims (9)
1. a kind of digestive tract is dispelled infusion, it is characterised in that：Including acid protease, Fructus Zanthoxyli extract, Endoconcha Sepiae and excipient, acid
Property protease optimum pH be 1.0-5.5.
2. digestive tract according to claim 1 is dispelled infusion, it is characterised in that：The excipient includes pH adjusting agent, institute
State one or more that pH adjusting agent is in carbonate, phosphate or borate.
3. digestive tract according to claim 2 is dispelled infusion, it is characterised in that：Also include stabilizer, institute in the excipient
Stabilizer is stated for cyclodextrin and/or poloxamer.
4. the digestive tract according to claim 1-3 any one is dispelled infusion, it is characterised in that：The digestive tract is dispelled infusion bag
Include acid protease 10-40 weight portion, Fructus Zanthoxyli extract 5-30 weight portion, Endoconcha Sepiae 5-20 weight portion and excipient 20-100 weight
Amount part.
5. digestive tract according to claim 4 is dispelled infusion, it is characterised in that：Digestive tract infusion of dispelling includes acidic protein
Enzyme 20-30 weight portion, Fructus Zanthoxyli extract 5-15 weight portion, Endoconcha Sepiae 5-10 weight portion and excipient 40-80 weight portion.
6. digestive tract according to claim 5 is dispelled infusion, it is characterised in that：Digestive tract infusion of dispelling includes acidic protein
Enzyme 20-30 weight portion, Fructus Zanthoxyli extract 5-10 weight portion, Endoconcha Sepiae 5-8 weight portion and excipient 40-70 weight portion.
7. digestive tract according to claim 6 is dispelled infusion, it is characterised in that：The granularity of the Endoconcha Sepiae is 100-800
Mesh.
8. digestive tract according to claim 7 is dispelled infusion, it is characterised in that：The granularity of the Endoconcha Sepiae is 300-500
Mesh.
9. the digestive tract described in a kind of claim 1-8 any one is dispelled the preparation method of infusion, it is characterised in that：Including following
Step：
(1) 100 mesh sieves are crossed load weighted acid protease, Fructus Zanthoxyli extract, Endoconcha Sepiae and excipient, mixes 15- afterwards
30min；
(2) mass concentration for adding acid protease, Pericarpium Zanthoxyli, Endoconcha Sepiae and excipient gross weight 5-15% weight portion is 50%
Alcoholic solution, continues mixing 20-50min；
(3) acid protease for mixing, Pericarpium Zanthoxyli, Endoconcha Sepiae and excipient are dry 20-60mim under the conditions of 30-65 DEG C, obtains
Digestive tract is dispelled infusion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610937294.XA CN106421763A (en) | 2016-10-25 | 2016-10-25 | Alimentary canal de-foaming agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610937294.XA CN106421763A (en) | 2016-10-25 | 2016-10-25 | Alimentary canal de-foaming agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106421763A true CN106421763A (en) | 2017-02-22 |
Family
ID=58178338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610937294.XA Pending CN106421763A (en) | 2016-10-25 | 2016-10-25 | Alimentary canal de-foaming agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106421763A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1180419A (en) * | 1995-02-10 | 1998-04-29 | 英国国防部 | Liquid crystal devce alignment |
-
2016
- 2016-10-25 CN CN201610937294.XA patent/CN106421763A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1180419A (en) * | 1995-02-10 | 1998-04-29 | 英国国防部 | Liquid crystal devce alignment |
Non-Patent Citations (5)
| Title |
|---|
| 姚静: "《药物辅料应用指南》", 31 August 2011, 中国医药科技出版社 * |
| 张洪渊: "《生物化学》", 28 February 2006, 化学工业出版社 * |
| 赵光荣: "花椒浸液在上消化道内窥镜检查前的应用", 《中国中西医结合杂志》 * |
| 陆彬: "《药剂学》", 31 January 2003, 中国医药科技出版社 * |
| 高学敏: "《中药学》", 31 December 2002, 中国中医药出版社 * |
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Application publication date: 20170222 |
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