CN106421234A - 一种治疗肾脾两亏型胎动不安的中药 - Google Patents

一种治疗肾脾两亏型胎动不安的中药 Download PDF

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CN106421234A
CN106421234A CN201610897115.4A CN201610897115A CN106421234A CN 106421234 A CN106421234 A CN 106421234A CN 201610897115 A CN201610897115 A CN 201610897115A CN 106421234 A CN106421234 A CN 106421234A
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李姝�
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Shanxian Lingxiang Honeysuckle Planting Cooperative
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Abstract

本发明公开了中医药技术领域，特别涉及一种治疗肾脾两亏型胎动不安的中药。该治疗肾脾两亏型胎动不安的汤剂包括以下原料：菟丝子25份，白芍20份，黄芪20份，党参20份，茯苓10份，川续断10份，陈皮6份，半夏7份，益母草10份，紫草15份，山茱萸10份，罗布麻15份，苏梗15份，茜草炭15份，百里香15份。本发明采用的药材相辅相成，根据中医理论组方，按照一定的重量配比配制而成对治疗肾脾两亏型胎动不安具有显著的疗效，而且其安全可靠，无毒副作用。

Description

一种治疗肾脾两亏型胎动不安的中药
（一）技术领域
本发明涉及中医药技术领域，特别涉及一种治疗肾脾两亏型胎动不安的中药。
（二）背景技术
妊娠早期见恶心呕吐、头晕头重、恶闻食气或食入即吐，以致影响正常的生活、学习与工作的症状，称为妊娠恶阻。一般以妊娠6～12周多见，少数病例持续到妊娠后期。此病不仅影响母体健康，且累及胎儿的生长发育。中医认为，妊娠恶阻主要是气血不足，冲脉之气上逆，脾胃失和所致。
怀孕后***不时有少量出血并伴有腰酸腹痛，小腹下坠为主要临床症状的妇科病证，称为胎动不安。胎动不安常是小产、堕胎的先兆，需谨慎注意。胎动不安多是由于母体和胎元两方面导致的气血不调，胎元不固而引起的。
现有的保胎、安胎药物能够治疗胎动不安等病症，但无法达到对妊娠恶阻治疗的目的，而且见效慢，用药量大，服用次数频繁，对孕妇和胎儿有一定的影响。
（三）发明内容
本发明为了弥补现有技术的不足，提供了一种治疗肾脾两亏型胎动不安的中药。
本发明是通过如下技术方案实现的：
一种治疗肾脾两亏型胎动不安的中药，其特征在于：包括以下重量配比的原料：菟丝子20-30份，白芍25-35份，黄芪15-22份，党参15-22份，茯苓8-20份，川续断8-20份，陈皮5-10份，半夏5-10份，益母草8-20份，紫草10-20份，山茱萸8-15份，罗布麻10-20份，苏梗10-20份，茜草炭10-20份，百里香10-20份。
进一步，包括以下重量配比的原料：菟丝子25份，白芍20份，黄芪20份，党参20份，茯苓10份，川续断10份，陈皮6份，半夏7份，益母草10份，紫草15份，山茱萸10份，罗布麻15份，苏梗15份，茜草炭15份，百里香15份。
其中，所述中药为汤剂或口服液，将上述重量组份中药洗净除杂，按常规中药制剂方法制成汤剂。
以下是本发明原料的功效：
菟丝子：补肾益精，养肝明目，固胎止泄；主治腰膝酸痛，遗精，阳痿，早泄，不育，消渴，淋浊，遗尿，目昏耳鸣，胎动不安，流产，泄泻；
白芍：养血和营，缓急止痛，敛阴平肝；主治血虚寒热，脘腹疼痛，胁痛，肢体痉挛疼痛，痛经，***，崩漏，自汗，盗汗，下痢泄泻，头痛眩晕；
黄芪：益气升阳，固表止汗，利水消肿，托毒生肌；主治一切气虚血亏之证，如脾虚泄泻，肺虚咳嗽，脱肛，子宫下垂，自汗，盗汗，水肿，血痹，痈疽难溃或久溃不敛；
党参：健脾补肺，益气生津。主治脾胃虚弱，食少便溏，四肢乏力，肺虚咳喘，气短自汗，气血两亏诸症；
茯苓：主治：小便不利，水肿胀满，痰饮咳逆，呕吐，脾虚食少，泄泻，心悸不安，失眠健忘，遗精白浊；
川续断：补肝，强筋骨，定经络，止经中（筋骨）酸痛，安胎，治妇人白带，生新血，破瘀血，落死胎，止慢性支气管炎咳血，治赤白便浊；
陈皮：理气调中，降逆止呕，燥湿化痰。主治胸膈满闷，脘腹胀痛，不思饮食，呕吐，哕逆；咳嗽痰多；
半夏：燥湿化痰，降逆止呕，消痞散结；主治咳喘痰多，呕吐反胃，胸脘痞满，头痛眩晕，夜卧不安，瘿瘤痰核，痈疽肿毒；
益母草：活血调经，利尿消肿，清热解毒。主***，经闭，胎漏难产，胞衣不下，产后血晕，瘀血腹痛，跌打损伤，小便不利，水肿，痈肿疮疡；
紫草：凉血活血，解毒透疹；主治吐血，衄血，尿血，紫癜，斑疹，黄疸，痈疽，烫伤；
山茱萸：补益肝肾，收敛固脱；主治头晕目眩，耳聋耳鸣，腰膝酸软，遗精滑精，小便频数，虚汗不止，妇女崩漏；
罗布麻：清热，平肝，安神，利水；主治高血压病，眩晕，心痛，心悸，失眠，水肿尿少；
苏梗：理气宽中，止痛，安胎；用于胸膈痞闷，胃脘疼痛，嗳气呕吐，胎动不安；
茜草炭：茜草炒炭后寒性降低，性变收涩，止血作用增强。
本发明的有益效果是：本发明采用的药材相辅相成，根据中医理论组方，按照一定的重量配比配制而成用于治疗肾脾两亏型胎动不安具有显著的疗效，而且其安全可靠，具有清热解毒、健脾养胃、滋阴补肾的作用，无毒副作用。
（四）具体实施方式
实施例1：
菟丝子20g，白芍25g，黄芪15g，党参15g，茯苓8g，川续断8g，陈皮5g，半夏5g，益母草8g，紫草10g，山茱萸8g，罗布麻10g，苏梗10g，茜草炭10g，百里香10g。
将上述重量组份中药洗净除杂，加水提取2-3次，每次加水量相当于药材总重量的6-12倍，每次提取时间为1-3小时，合并提取液，滤过，口服，每日1次，每次200ml，7天为一疗程。
实施例2：
菟丝子30g，白芍35g，黄芪22g，党参22g，茯苓20g，川续断20g，陈皮10g，半夏10g，益母草20g，紫草20g，山茱萸15g，罗布麻20g，苏梗20g，茜草炭20g，百里香20g。
将上述重量组份中药洗净除杂，加水提取2-3次，每次加水量相当于药材总重量的6-12倍，每次提取时间为1-3小时，合并提取液，滤过，口服，每日1次，每次200ml，7天为一疗程。
实施例3：
菟丝子25g，白芍20g，黄芪20g，党参20g，茯苓10g，川续断10g，陈皮6g，半夏7g，益母草10g，紫草15g，山茱萸10g，罗布麻15g，苏梗15g，茜草炭15g，百里香15g。
将上述重量组份中药洗净除杂，加水提取2-3次，每次加水量相当于药材总重量的6-12倍，每次提取时间为1-3小时，合并提取液，滤过，口服，每日1次，每次200ml，7天为一疗程。

Claims (3)

1.一种治疗肾脾两亏型胎动不安的中药，其特征在于：包括以下重量配比的原料：菟丝子20-30份，白芍25-35份，黄芪15-22份，党参15-22份，茯苓8-20份，川续断8-20份，陈皮5-10份，半夏5-10份，益母草8-20份，紫草10-20份，山茱萸8-15份，罗布麻10-20份，苏梗10-20份，茜草炭10-20份，百里香10-20份。
2.根据权利要求1所述的治疗肾脾两亏型胎动不安的中药，其特征在于：包括以下重量配比的原料：菟丝子25份，白芍20份，黄芪20份，党参20份，茯苓10份，川续断10份，陈皮6份，半夏7份，益母草10份，紫草15份，山茱萸10份，罗布麻15份，苏梗15份，茜草炭15份，百里香15份。
3.根据权利要求1或2所述的治疗肾脾两亏型胎动不安的中药，其特征在于：所述中药为汤剂。
CN201610897115.4A 2016-10-14 2016-10-14 一种治疗肾脾两亏型胎动不安的中药 Pending CN106421234A (zh)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1565570A (zh) * 2003-07-05 2005-01-19 姚克敏 治疗胎漏、胎动不安制剂及其制备方法
CN102106984A (zh) * 2009-12-23 2011-06-29 廖益伦 一种用于治疗妊娠恶阻和胎动不安的药物组合物
CN102698184A (zh) * 2012-06-26 2012-10-03 刘天岐 砂仁止呕安胎丸

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1565570A (zh) * 2003-07-05 2005-01-19 姚克敏 治疗胎漏、胎动不安制剂及其制备方法
CN102106984A (zh) * 2009-12-23 2011-06-29 廖益伦 一种用于治疗妊娠恶阻和胎动不安的药物组合物
CN102698184A (zh) * 2012-06-26 2012-10-03 刘天岐 砂仁止呕安胎丸

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张良英: "《推崇景岳 善治经孕诸疾：张良英学术思想与临床经验集》", 31 January 2015, 中国中医药出版社 *

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Application publication date: 20170222