CN106417939B - A kind of application of N- carbamylglutamic acid in the feed that preparation promotes Lamb Growth - Google Patents
A kind of application of N- carbamylglutamic acid in the feed that preparation promotes Lamb Growth Download PDFInfo
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- CN106417939B CN106417939B CN201611126164.4A CN201611126164A CN106417939B CN 106417939 B CN106417939 B CN 106417939B CN 201611126164 A CN201611126164 A CN 201611126164A CN 106417939 B CN106417939 B CN 106417939B
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- lamb
- growth
- ncg
- ewe
- carbamylglutamic
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- 230000012010 growth Effects 0.000 title abstract description 31
- 238000002360 preparation method Methods 0.000 title abstract description 4
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Landscapes
- Fodder In General (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention relates to a kind of application of N- carbamylglutamic acid (N-carbamylglutamate, NCG) in the feed that preparation promotes Lamb Growth.By gavaging N- carbamylglutamic acid daily to lamb, or by adding N- carbamylglutamic acid in Ewe in suckling period TMR daily ration, the milk composition to improve ewe can promote Lamb Growth again to lamb lactation, reduce that lamb diarrhoea rate, collapse from physical exhaustion disease incidence.The application that present invention firstly provides N- carbamylglutamic acids in the drug or feed for promoting Lamb Growth can promote its growth and development, it is without side-effects, it can improve food conversion ratio, enhance animal body immune function, improve dam milk composition, trophic level is improved, and then improves the number of weaned of lamb.
Description
Technical field
The invention belongs to animal feed, it is related to the feed that a kind of N- carbamylglutamic acid promotes Lamb Growth in preparation
And its application.
Background technique
Lamb diarrhoea is the disease that one kind is common in sheep husbandry, causes there are many kinds of the reason of lamb diarrhoea, most common
Be that feeding management is improper, the diarrhea caused by supporting simple indigestion caused by Hang Li difference etc. of lamb.Clinically lamb
The disease incidence of diarrhea may be up to 30%, and case fatality rate is up to 20%, especially the lamb more susceptible disease of wean front and back.Diarrhea lamb is drawn
Dilute, thin, apathetic, loss of appetite, serious person 1-2d are dead.Clinically lamb diarrhoea is treated can fully recover mostly, but send out
Dehydration, loss of appetite caused by disease have but seriously affected the growth of lamb, lead to lamb slow growth, economic benefit decline.Separately
Outside, if feeding management is improper, lamb diarrhoea meeting recurrent exerbation, the medical expenses for treating generation increase aquaculture cost, make to support
Grow economic benefit reduction.Lamb collapse from physical exhaustion be occur on drylot feeding goat nursing period lamb in recent years one kind based on weak and limp symptom
The lamb disease of feature is wanted, nearly two annual morbidity of the disease increased significantly, the lamb hair especially in biggish scale sheep raising, family
Sick rate is higher, and the serious death rate is up to 40%-60% etc., causes great economic loss to sheep husbandry.So lamb is soft
Paralysis and diarrhea are huge to sheep husbandry harm, severely impact the development and economic benefit of sheep husbandry.Therefore it proposes targetedly pre-
Anti- method, the morbidity and mortality to collapse from physical exhaustion for reducing lamb with diarrhea, and then its number of weaned is improved to raising goat
The economic benefit of cultivation is of great significance.
The nutrition supply situation of ewe nursing period and the gestational period (especially latter half of gestation), to the growth and development of lamb, anti-
It only collapses from physical exhaustion and has played important role with diarrhea.Latter half of gestation embryo growth and development is fast, and the most weight of fetus is in latter half of gestation
It is formed.Therefore, the feeding management of this phase has the raising of the growth and development in fetus all one's life and entire production performance, economic benefit
Great influence.Ewe lamb birth weight produced meticulously after feeding is high, and body condition is healthy and strong, and premunition is strong.Ewe once occurs
Nutritional deficiency, then its lamb body condition produced is weaker, and malnutritive and diarrhea disease incidence is higher, such as egg contained in daily ration
The content of the nutriments such as white matter, vitamin is very few or the ratio of various nutriments is improper, not only influences the development of fetus,
It also results in after lamb birth that physique is small, constitution is poor, also influences the quality of colostrum, new-bom lamb is made to drink the colostrum less than high quality,
Enough maternal antibodies cannot be obtained, these two aspects all causes lamb autoimmunity low, the shadow vulnerable to outside environmental elements
It rings and diarrhea occurs.Ewe nursing period malnutrition causes galactosis deficiency, nutritional quality bad, and lamb does not have enough to eat, nutrition
Lack, resistance is poor, increases the morbidity and mortality of diarrhea.
Cud develops not perfect, gut development prematurity, function insufficiency, in early stage nursing period to lamb at birth
Nutrition supply mostly come from ewe milk, the nutritional ingredient and the output of milk of milk determine the growth and development state of lamb.
Lamb autoimmunity lacks, and new-bom lamb cannot be able to eat colostrum, growth retardation, vulnerable, itself rabbit epidemic disease power in time
It is low also easily to cause to collapse from physical exhaustion and diarrhea.Digestion power of the lamb to vegetable protein and long chain fatty acids in powered milk substitute and opening material
It is weak, when feed is nondigestible, of poor quality, Yi Fasheng indigestion and diarrhea.In addition, if lamb constitution is weak, weight is small, to the external world
The adaptive faculty of environment, the resistance to disease and the tolerance to milk quality are all poor, also easily cause diarrhea.
In short, lamb is caused to collapse from physical exhaustion or diarrhea, and then slow down the principal element of Lamb Growth are as follows: (1) ewe is pregnant
It is pregnent phase nutritional deficiency, leads to that institute's lambing sheep body condition is weak, birth weight is relatively low；(2) nursing period of ewe is malnutritive, reduces dairy products
Matter keeps lamb immunity power low；(3) lamb own growth and development is slow, to extraneous bad adaptability.So how effectively to solve
Problem above is an important factor for restricting sheep husbandry development.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of methods in feed for promoting Lamb Growth.
In order to solve the above technical problems, the technical solution adopted by the present invention is that:
A kind of application of N- carbamylglutamic acid in the feed for promoting Lamb Growth.
One of method of the application the following steps are included:
(1a) Ewe in suckling period fully mixed diet (TMR) feeding, free water are freely eaten；
(2a) lamb freely eats she-goat milk described in step (1a)；
(3a) lamb gavages N- carbamylglutamic acid (N-carbamylglutamate, NCG) daily, to reduce lamb abdomen
Rush down rate, collapse from physical exhaustion disease incidence, promotion Lamb Growth.
In step (3a), the amount for taking N- carbamylglutamic acid is that lamb age in days from 1 to 41 gavages 80- daily
120mg/ kg body weight (kg BW).
Described take is a point morning, evening each 1 time, and N- carbamylglutamic acid aqueous solution is injected lamb with the syringe without syringe needle
Sheep oral cavity.
Another method of the application the following steps are included:
(1b) Ewe in suckling period TMR Diet, free water are freely eaten, and feed and add N- ammonia in daily ration
Carbamylglutamic, to improve the milk composition of ewe；
(2b) lamb freely eats the milk of she-goat described in step (1b).
In step (1b), the additive amount of the N- carbamylglutamic acid is daily 1~3 gram of every ewe, preferably every
Daily 2~2.5 grams of ewe, can most effective promotion ewe, plasma amino acids level, improve milk performance, improve milk composition.
During the feeding method of the N- carbamylglutamic acid is Lamb, every natural gift are early, evening gavages 1 N- carbamylglutamic acid
Aqueous solution.
In step (1a) or (1b), the daily ration be include following substance mass percent composition: beanstalk
32.35%, corn 36.80%, wheat bran 10.73%, dregs of beans 16.80%, calcium monohydrogen phosphate 0.60%, sodium bicarbonate 0.12%, food
Salt 0.50%, premix 2.10%.The premix be every kilogram of fully mixed diet dry matter in provide: Fe 56mg, Cu
15mg, Zn 40mg, I 1mg, Mn 30mg, Se 0.2mg, Co 0.25mg, VA2150IU, VD 170IU, VE 13IU, quality
The Monensin 1.6g, sodium sulphate 10.1g that percentage is 2%.The dry matter of the fully mixed diet refers to not include premix
Fully mixed diet.
The study found that external source supplies dam arginine, nutritional ingredient and its metabolism in dam blood plasma can be effectively increased and produced
The level of object, to promote the growth and development of fetus.And to young animal, arginine is the condition for playing optimum growh performance
Property essential amino acid, promoting the synthesis of cub intestinal protein matter, improving intestinal immunity, inoxidizability and maintenance intestinal health etc.
Just all play a significant role.Arginine all plays non-in protein anabolism and polyamines and nitric oxide production synthesis
The physiology of normal important role, these products and body, metabolism and nutrition immune function are closely related, and arginine is promoting
It stayed into the synthesis of muscle internal protein, increase body nitrogen storage, enhance immunity of organisms, cell division, wound restores and hormone secretion
Etc. having important role in various physiology courses.Therefore, arginine supplement promotes its growth and development tool for alleviating lamb diarrhoea
It is significant.
Animal body arginine main source includes: (1) feed, the decomposition of (2) body protein, and (3) small intestine film carrier is thin
Born of the same parents synthesize arginine under catalytic action using other amino acid (glutamic acid, citrulling etc.) in body.Due to ammonia smart in small intestine
The decomposition of sour enzyme, only 60% arginine are able to enter blood circulation.Therefore feed is only relied on to provide and parent itself conjunction
It is (especially latter half of gestation) normal fetal growth and development between not being able to satisfy the gestational period at arginine.On ruminant, if
Major part is degraded in cud, cannot be introduced into small intestine and be absorbed by Direct-fed arginine.Moreover, arginine ruminate it is dynamic
The arginic high cost of high degradation rate and ruminally-protected in object cud limits its application in feed industry.Simultaneously
The side effect that arginine is directly fed is big, it is also possible to will lead to the reduction of other essential amino acids in blood plasma.So finding one kind
Arginine can effectively be supplemented on ruminant to promote the growth and development of lamb, reduce the method evidence to collapse from physical exhaustion with diarrhea rate
It is significant.
N- carbamylglutamic acid (N-carbamylglutamate, NCG) is arginine synthesis activator N-acetylglutamat
(NAG) analogue can synthesize the activity of rate-limiting enzyme carbamyl phosphate synthetase-I (CPS- I) by improving arginine
Come promote enterocyte arginine synthesize, therefore, NCG is a kind of arginine reinforcing agent.NCG long half time, about 8- in animal body
10 hours, arginic generation can promote by urea cycle, body arginine is made to maintain higher physiological concentration.Arginine
It can produce NO and polyamines (putrescine, spermidine, spermine), NO is in immune system, cardiovascular system, gastronintestinal system, genito-urinary system
System, respiratory system, peripheral neverous system, central nervous system etc. play an important role.Relative to arginine, NCG is in cud
In degradation rate it is extremely low.Different from NAG, NCG will not be decomposed by the deacylase of high activity in mammalian cell matter, this is special
Property makes it easier to play a role into cell mitochondrial.The present invention is by a large amount of it is demonstrated experimentally that NCG has in sheep produces
Following effect: (1) improve wet sheep milk composition, dramatically increase the content of amino acid in cream.(2) promote lamb intestinal growth,
Alleviate diarrhea, improve absorption of nutrient ingredients, promotes growth, improve the immunity of body.Using NCG as arginine reinforcing agent application
In animal experiment, degradation of the cud to NCG is avoided, breeding performonce fo animals can be significantly improved.Lamb feed NCG into
Row raising discovery, NCG can improve daily gain, alleviate diarrhea, prevent the syndrome that collapses from physical exhaustion, and then reduce the death of lamb；Moreover,
NCG can also effectively facilitate the development of stomach and intestine villus, increase the opposite specific gravity of the digestive organs such as gastrointestinal tract, and then accelerate to digest and assimilate
The acquisition of ability.
The utility model has the advantages that the application present invention firstly provides N- carbamylglutamic acid in the feed for promoting Lamb Growth
It can promote the growth and development of Lamb, it is without side-effects, amino acid content in blood can be improved, body's immunity is enhanced,
Improve breast milk composition and partial amino-acid content, reduction collapses from physical exhaustion and diarrhea rate.
Specific embodiment
According to following embodiments, the present invention may be better understood.However, as it will be easily appreciated by one skilled in the art that real
It applies content described in example and is merely to illustrate the present invention, without sheet described in detail in claims should will not be limited
Invention.
* or the different letters of mark indicate that group difference is significant (P < 0.05) in following embodiment, and t value is T test value.
Embodiment 1: N- carbamylglutamic acid is gavaged to lactation kidlet growth performance, blood parameters and diarrhea rate
Influence
Test material: it tests NCG used and is purchased from Asia-Pacific Xing Mu Science and Technology Ltd., production licence number is that Henan feeding adds
(2014) T05005, product purity 97%；
Experimental animal: 1 age in days boer goat × Haimen goat hybrid male lamb that 32 birth weight are close, health is disease-free is chosen
As test sheep, it is divided into control group (I group) and NCG group (II group), every group 16.In order to exclude the ewe output of milk and lactation lamb
Potential impact of the sheep number to lactation kidlet growth performance, every she-goat lactation 2 public lambs, and guarantee that every she-goat feeds
The public lamb of cream is divided into 2 different groups.Wet sheep list column is fed during feeding management and sample acquisition test, free water, from
By searching for food；Lamb Free nursing.According to sheep scheduling of production during test, expelling parasite, epidemic prevention are carried out to test lamb.
The nutritional need for the sock lamb that wet sheep TMR daily ration is recommended referring to NRC (2007) is prepared, and main composition is shown in Table 1,
Major Nutrient index is shown in Table 2.
1 wet sheep TMR daily ration of table composition
2 wet sheep TMR diets of different nutrition level of table
Experimental period: experimental period 40 days, lamb age in days from 1 to 41.
Experimental method: NCG group feeds the NCG of 100mg/kg BW daily；Divide morning, feed for evening each 1 time.NCG is mixed with warm water
Lamb oral cavity is slowly injected into the 5mL syringe without syringe needle afterwards；Control group only feeds isometric warm water in same time, does not fill
Feed NCG.
Lamb sampled plasma: when lamb 1,21 and 41 age in days, 5 lambs are randomly selected from every group, gavage NCG morning
After 2h or warm water, rear jugular vein blood collection 5mL is engraved on 3 000r/min centrifugation 8min in the heparin sodium anticoagulant tube of sterilizing, point
From blood plasma, frozen in -20 DEG C.
(1) lamb grows performance measurement:
Every group of lamb is in weighing 1 time on an empty stomach of 1,21 and 41 ages in days, and lamb is in fasting state when to guarantee weighing, and weighing is worked as
Lamb is embraced from wet sheep immediately after its blood sampling, is weighed after 12h.Average daily gain is calculated, formula is as follows: average daily gain
(kg/d)=(last weight-initial weight)/number of days.
As shown in Table 3, compared with the control group, 41 age in days weight of NCG group lamb improves 0.89kg (P < 0.05), and 21~41
Age in days and 1~41 age in days average daily gain significantly improve (P < 0.05)；But NCG is flat to 21 age in days weight of lamb and 1~21 age in days
Equal daily gain influences not significant (P > 0.05)；Relative to control group, NCG group lamb diarrhoea rate significantly reduces (P < 0.05).
Table 3 gavages influence of the NCG to lactation kidlet growth performance and diarrhea rate
Marking * indicates significant difference
(2) measurement of plasma biochemical index
Lamb 1,21 and 41 ages in days are acquired clinical with Vital Scientific after isolated plasma sample thaws in 4 DEG C
Chemical analyzer measure glucose (GLU), total protein (TP), albumin (ALB), urea nitrogen (UN), ammonia, triglycerides (TG),
The content of total cholesterol (TC).
As shown in Table 4,1 age in days plasma biochemical index of NCG group lamb and the significant indifference of control group (P > 0.05)；NCG group
41 age in days blood plasma TP and ALB content of lamb is significantly higher than control group (P < 0.05)；But ammonia in NCG group lamb 21 and 41 age in days blood plasma
(P < 0.05) is significantly reduced with UN content.
Table 4 gavages influence of the NCG to lactation kidlet plasma biochemical index
(3) measurement of blood plasma hormone content
41 age in days of lamb is acquired isolated plasma sample to thaw in 4 DEG C, (is stepped purchased from Shanghai card using ELISA kit
Easypro Biotechnology Co., Ltd) measurement blood plasma GH, insulin (Ins) and nitric oxide (NO) content.
As shown in Table 5, in 1 age in days NCG group lamb blood plasma Hormone traits compared with the control group without significant difference (P > 0.05)；
Relative to control group, GH, Ins and NO content significantly increase (P < 0.05) in the NCG group lamb blood plasma of 21 and 41 ages in days.
Table 5 gavages influence of the NCG to lactation kidlet blood plasma hormone and content of nitric oxide
(4) measurement of plasma amino acids level
41 age in days of lamb is acquired isolated plasma sample to thaw in 4 DEG C.When measurement, 0.3mL plasma sample and 10% are taken
Sulfosalicylic acid presses 1:3 dilution proportion, mixes, and 12 000r/min are centrifuged 30min at room temperature, supernatant is taken, with Hitachi L-8800
Automatic amino acid analyzer measurement.As shown in Table 6, compared with the control group, NCG group lamb plasma arginine, citrulling and bird ammonia
Acid content significantly increases (P < 0.05).
Table 6 gavages influence of the NCG to lactation kidlet plasma amino acids level
(5) influence of NCG groups of kidlet relative organ weights is gavaged
As shown in Table 7, after gavaging NCG, each relative organ weights of lamb are increased, wherein NCG group lamb spleen, small
Intestines and large intestine relative weight are all remarkably higher than control group (P < 0.05).
Table 7 gavages influence (g/kg) of the NCG to lactation kidlet relative organ weights
Embodiment 2:N- carbamylglutamic acid supplements nursing period goat daily ration arginine to the shadow of nursing period goat and lamb
It rings
Test material: it tests NCG used and is purchased from Asia-Pacific Xing Mu Science and Technology Ltd., production licence number is that Henan feeding adds
(2014) T05005, product purity 97%.
Experimental animal: 64 body conditions of selection are close, and bohr × Haimen goat of primiparity carries out feeding experiment；It is randomly divided into 4
Group, every group 16, respectively I, II, III, IV group；Eliminate the potential impact of gender and the growth of lambing lamb.In lactation goat
In the 42d of nursing period, nursing period daily ration is provided；Nursing period goat provides the diet containing 12.43MJ/kg and 15.85%CP, often
Its feeding is twice (07:00,17:00).Wet sheep list column is fed during feeding management and sample acquisition test, free water,
It is freely eaten.Lamb Free nursing.According to sheep scheduling of production during test, expelling parasite, epidemic prevention are carried out to test lamb.
Wet sheep basis nursing period diet nutrient ingredient is shown in Table 1, and Major Nutrient index is shown in Table 2.
0 (control group) of addition respectively, the NCG of 1,2 or 3g/d are added in every group of goat nursing period feeding daily ration of I~IV.
Experimental period: experimental period 42 days.
(1) influence of the feed addition NCG to goat dairy metabolin and amino acid content
Measurement result is shown in Table 8 at nursing period 21 days, fat, lactose and solid-not-fat (SNF) in milk sample, control group with
There is no the influence of conspicuousness between NCG group.Compared with the control group, the milk fat content for adding Group IV obviously increases (P <
0.05) II~IV group (addition NCG group) is compared with I group (control group), the putrescine in milk, and the content of spermine, spermidine is significant
Increase.
Influence of the 8 feed addition NCG of table to goat milk composition and newborn metabolin
Marking different letters indicates that group difference is significant (P < 0.05), and unmarked or mark same letter indicates that difference is not shown
It writes (P > 0.05), following table is same.
(2) influence of the feed addition carbamylglutamic (NCG) to amino acid concentration in nursing period goat milk
The concentration results of total amino acid (two kinds of protein bindings and freedom) at nursing period the 21st day are shown in Table 9:II~IV group
(addition NCG group) compared with I group (control group), the amino acid concentration in milk does not have the influence (P > 0.05) of conspicuousness.So
And Group IV, compared with Group I, there are alanine, threonine, glycine, phenylalanine, glutamic acid, serine, tyrosine contain
Measure increased trend (P < 0.10).
Influence of the 9 feed addition carbamylglutamic (NCG) of table to amino acid concentration in nursing period goat milk
The present invention by a large amount of experiments have shown that: add NCG in wet sheep daily ration, there is following make in sheep production
With: (1) improve wet sheep milk composition, dramatically increases the content of amino acid in cream；(2) promote lamb intestinal growth, alleviate abdomen
It rushes down, improves absorption of nutrient ingredients, promote growth, improve the immunity of body.Lamb feeds NCG, has in sheep production
Following effect: (1) improving Lamb daily gain, alleviates diarrhea, prevents the syndrome that collapses from physical exhaustion, and then reduce the death of lamb；(2) effectively
Promote the development of stomach and intestine villus, increases the opposite specific gravity of the digestive organs such as gastrointestinal tract, and then accelerate the acquisition of abilities of digestive and absorption.
Claims (1)
1. a kind of N- carbamylglutamic acid is improving the application in wet sheep milk composition；Characterized by comprising the following steps:
The feeding of (1b) Ewe in suckling period fully mixed diet, free water are freely eaten, and N- ammonia is added in the fully mixed diet of feeding
Carbamylglutamic to improve the milk composition of ewe, and then promotes the development of lamb；(2b) lamb freely eats institute in step (1b)
State the milk of she-goat；
In step (1b), the fully mixed diet includes the composition of the mass percent of following substance: beanstalk 32.35%, corn
36.80%, wheat bran 10.73%, dregs of beans 16.80%, calcium monohydrogen phosphate 0.60%, sodium bicarbonate 0.12%, salt 0.50%；Also wrap
Include premix 2.10%；The premix be every kilogram of fully mixed diet dry matter in provide: Fe56mg, Cu15mg,
Zn40mg, I1mg, Mn30mg, Se0.2mg, Co0.25mg, VA2150IU, VD170IU, VE13 IU, mass percent 2%
Monensin 1.6g, sodium sulphate 10.1g；In step (1b), the additive amount of the N- carbamylglutamic acid is fully mixed diet
In daily 1~3 gram of every ewe.
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