CN106399074A - Multiplex bioreactor system - Google Patents
Multiplex bioreactor system Download PDFInfo
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- CN106399074A CN106399074A CN201610389013.1A CN201610389013A CN106399074A CN 106399074 A CN106399074 A CN 106399074A CN 201610389013 A CN201610389013 A CN 201610389013A CN 106399074 A CN106399074 A CN 106399074A
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- bioreactor
- bioreactor system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/58—Reaction vessels connected in series or in parallel
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
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Abstract
The invention discloses a multiplex bioreactor system. The multiplex bioreactor system comprises an integrated cabinet, a processing device, and N sets of biological reaction monitoring devices arranged on the integrated cabinet, wherein N is greater than or equal to 2 and is a natural number; the biological reaction monitoring devices comprise bioreactors used for culturing microbes, and monitoring devices used for monitoring the bioreactors; the monitoring devices are electrically connected with the processing device and send the monitored experimental data to the processing device; the processing device comprises a display, and the experimental data monitored by the monitoring devices is simultaneously displayed on the display. Compared with the prior art, the multiplex bioreactor system has the advantages that the data in the plurality of microbial bioreactors is subjected to contrastive analysis through one processing device, so that the work efficiency is improved, and the monitored data can be sent to the display capable of simultaneously displaying the experimental data, so that an experimenter can rapidly and visually compare the experimental data.
Description
Technical field
The present invention relates to a kind of bioreactor system, particularly to a kind of multi-joint bioreactor system
System.
Background technology
Bioreactor refers to carry out cell proliferation or biochemical reaction with living cells or enzyme for biocatalyst
The equipment of control environment is provided.In biological biochemistry course of reaction, need in real-time monitoring bioreactor
Situation, gather substantial amounts of experimental data, thus carrying out data analysis contrast, draw optimum culture bar
Part.
Bioreactor of the prior art, is independent design, and each bioreactor is only capable of monitoring one
Individual incubation.But one complete cultivation cycle of part biological can be up to 1 month, if only with 1
Platform bioreactor is contrast experiment repeatedly, then cultivation cycle will be extremely very long.If experimenter uses many
Platform bioreactor is contrast experiment simultaneously, then need process to be all separately configured to every bioreactor and set
Standby, not only expensive, and also different bioreactors is all single reflection culture data and song
Line it is impossible to more same interface carry out parallel contrast, have a strong impact on the accuracy of Data Comparison.
Therefore, how to bioreactor within the shortest time, monitor in real time, quick obtain accurately real
Test data and show on same interface, facilitate experimenter's observed data result, draw the culture of optimum
Condition is the problem to be solved in the present invention.
Content of the invention
It is an object of the invention to provide a kind of multi-joint bioreactor system is so that experimenter passes through
One processing equipment is analyzed the training so that microorganism to the data in multiple stage microorganism reactor
Monitoring Data can be sent to and can show on the display of experimental data simultaneously by foster cycle time, side
Just experimenter quickly obtains accurate experimental data.
For solving above-mentioned technical problem, embodiments of the present invention provide a kind of multi-joint bioreactor
System, comprises：One integrated cabinet, processing equipment, a N are set on the biology on described integrated cabinet
Reaction monitoring equipment, N >=2 and N are natural number；Described biological respinse monitoring device comprises micro- for cultivating
The bioreactor of biology, the monitoring device for monitoring described bioreactor；Described each monitoring device
It is electrically connected with described processing equipment and send the experimental data being monitored to described processing equipment；
Described processing equipment comprises display, and shows described each monitoring device institute on the display simultaneously
The experimental data monitoring.
Embodiment of the present invention in terms of existing technologies, because multi-joint bioreactor system is by one
Individual integrated cabinet, a processing equipment and N are set on the biological respinse monitoring device on described integrated cabinet,
Composition.By a processing equipment, the data in multiple stage microorganism reactor is analyzed, improves
Operating efficiency, monitoring device sends the experimental data being monitored to processing equipment；Due to processing equipment
Comprise display, and show the experimental data that each monitoring device is monitored over the display simultaneously, enter
And facilitate the comparative experiments data of experimenter's quicklook.
In addition, described multi-joint bioreactor system also comprises the storage for storing described experimental data
Equipment, described storage device is electrically connected with described processing equipment.Can be stored in a large number by storage device
Experimental data so that processing equipment can fast and accurately obtain experimental data and record queries history number
According to.
In addition, described multi-joint bioreactor system also comprises communication apparatus, cloud server, movement
Terminal, described processing equipment is electrically connected with described communication apparatus and passes through described communication apparatus and will be monitored
To experimental data be uploaded in described cloud server, described mobile terminal read by wireless signal or
Download the experimental data in described cloud server.By communication apparatus by the experimental data being monitored
Reach in cloud server, mobile terminal is read by wireless signal or downloads the experiment in cloud server
Data, it is possible to achieve the remote monitoring of mobile terminal.
In addition, described mobile terminal is mobile phone and/or panel computer.When experimenter is not indoor in experiment,
Facilitate lab assistant to understand the related data in experiment whenever and wherever possible, simultaneously facilitate experimenter and carry.
In addition, described integrated cabinet is provided with the locating slot coordinating described bioreactor, described each biology
Reactor is located in described each locating slot respectively.For more firm being fixed on integrated cabinet of bioreactor,
Integrated cabinet is provided with the locating slot of cooperation bioreactor.
In addition, described monitoring device comprises the weighing device for weighing described bioreactor weight；
Described each weighing device is separately positioned on described each positioning trench bottom and is electrically connected with described processing equipment respectively
Connect.By weighing device, bioreactor is weighed, detection means obtains what bioreactor was weighed
Data, and then realize the monitoring to bioreactor weight.
In addition, described integrated cabinet surface is provided with respectively attachment material source, water source, power supply, source of the gas
Line concentration quick union, the material pipeline of described each bioreactor, water pipeline, electric line, gas pipeline divide
It is not connected with described line concentration quick union.Because integrated cabinet surface is provided with attachment material source, water respectively
Source, power supply, source of the gas line concentration quick union so that the material pipeline of each bioreactor, water pipeline,
Electric line, gas pipeline are connected with line concentration quick union respectively, need not secondary pipe arrangement, be easy to experimenter behaviour
Make, avoid live exposed pipeline simultaneously, make culture environment neat and tidy.
In addition, be fixed with described integrated cabinet coordinating the pipeline of described bioreactor, pump, instrument
Table, electric controling element.By being fixed with the cooperation pipeline of bioreactor, pump, instrument, electrically
Control element, can improve required life and nutritional condition for microorganism, provide a clean and tidy culture ring
Border.Simultaneously because integrated cabinet device height is integrated, reduce hold facility lab space.
In addition, the lower section of described integrated cabinet is provided with roller.When needing to shift integrated cabinet, due to collection
Become and carry roller below cabinet, facilitate experimenter to carry.
Brief description
Fig. 1 is the multi-joint bioreactor system structural representation in first embodiment of the invention；
Fig. 2 is the multi-joint bioreactor system connected mode schematic diagram in second embodiment of the invention.
Specific embodiment
For making the object, technical solutions and advantages of the present invention clearer, below in conjunction with accompanying drawing to this
Each embodiment of invention is explained in detail.However, those of ordinary skill in the art can manage
Solution, in each embodiment of the present invention, in order that reader more fully understands that the application proposes many skills
Art details.But, even if do not have these ins and outs and the many variations based on following embodiment and
Modification is it is also possible to realize each claim of the application technical scheme required for protection.
The first embodiment of the present invention is related to a kind of multi-joint bioreactor system.As shown in figure 1, should
Multi-joint bioreactor system is by 2, processing equipment 3 of an integrated cabinet and to be arranged on integrated cabinet 2
On biological respinse monitoring device composition.
Wherein, biological respinse monitoring device is by for cultivating the bioreactor 1 of microorganism and being used for supervising
The monitoring device 5 surveying bioreactor 1 forms；Each monitoring device 5 is processed by data wire connection respectively
Equipment 3, and the experimental data being monitored is sent to processing equipment 3；Processing equipment 3 is by different realities
Test data to show by display simultaneously.
By the above it is seen that, monitoring device 5 will monitor the experiment number that obtains of bioreactor 1
According to, processing equipment 3 is passed to by data wire, the experimental data in processing equipment 3, will by display
Experimental data is shown by the form of chart.And multi-joint bioreactor system can be biological by multiple stage
The experimental data of reactor 1 passes through a processing equipment 3 to the experiment number in multiple stage microorganism reactor 1
According to being analyzed, improve experimenter's operating efficiency, monitoring experimental data is sent to can be simultaneously
On the display of display experimental data, facilitate the comparative experiments data of experimenter's quicklook, Jin Erxuan
Go out the condition of culture of optimum.
Specifically, in the present embodiment, as shown in figure 1, integrated cabinet 2 upper surface is provided with multiple stage life
Thing reactor 1, is provided with material source capsule line, water source pipeline, power line, source of the gas on bioreactor 1
Pipe joint, wherein, the position coordinating bioreactor 1 in integrated cabinet 2 upper surface is provided with connection material
Source, water source, power supply, the line concentration quick union 4 of source of the gas, and processing equipment 3 pass through data wire with integrated
Monitoring device 5 on cabinet 2 is connected.
Further, in the present embodiment, due to every bioreactor 1 be required for independent and outer
The water, electricity, gas on boundary connect, and bother very much, and a large amount of relevant connection pipeline can only exposed outside,
Seem that culture environment is disorderly and unsystematic, in order to avoid the problems referred to above, can be by the pipe of cooperation bioreactor 1
Road, pump, instrument, electric controling element are fixedly mounted in integrated cabinet 2 so that integrated cabinet 2 equipment is high
Degree is integrated, reduces hold facility lab space, and then provides a clean and tidy culture for biological culture
Environment, can accomplish need not secondary pipe arrangement, it is to avoid live exposed pipeline phenomenon, is easy to experimenter's operation,
Make culture environment neat and tidy.It is noted that in experimentation, needing for bioreactor 1
Interior biological offer nutriment and necessary environmental condition, to ensure that biology can be with normal activity, in collection
Cabinet 2 surface is become to be provided with attachment material source, water source, power supply, the line concentration quick union 4 of source of the gas respectively,
When needing for biological offer nutriment and necessary environmental condition, only need to be by the thing of bioreactor 1
Expects pipe line, water pipeline, electric line, gas pipeline are connected with line concentration quick union 4 respectively, and nutriment is just
Can enter in bioreactor 1 by pipeline each on bioreactor 1, so that biology can be normal
Activity.Additionally, entering into nutriment in bioreactor 1 and gas is controlled by power switch
System.
It should be noted that for more firm being fixed on integrated cabinet 2 of bioreactor 1, integrated cabinet
2 locating slots being provided with cooperation bioreactor 1, wherein locating slot are a circular inner groovy, and depth is
Three centimetres, the top of groove is provided with the bracing frame that can adjust bioreactor 1 height, bracing frame with recessed
Groove is individual components.And in actual application process, in order to preferably fix bioreactor 1,
Support can also be integrally formed with groove, in the present embodiment, this process is not specifically explained
State.
In addition, in actual use, need integrated cabinet 2 is carried, in order to mitigate experiment people
Member's workload, the lower section of integrated cabinet 2 is increased roller 6, and wherein roller 6 is located at integrated cabinet 2 lower surface
Each angle on, when experimenter's transfer integrated cabinet 2, because integrated cabinet 2 lower section carries roller 6, rolling
Wheel 6 can drive integrated cabinet 2 mobile, and then facilitates experimenter's carrying integrated cabinet 2.
In real process, monitoring device 5 comprises the dress of weighing for weighing bioreactor 1 weight
Put；Each weighing device is directly connected to by data wire with processing equipment 3 respectively.By weighing device opposite
Thing reactor 1 is weighed, and obtains experimental data of weighing, and then realizes the monitoring to bioreactor 1.
It should be noted that do culture experiment need more bioreactor 1 when, can arbitrarily increase biology
The quantity of reactor 1, to obtain more comparative experimental data, wherein, in the present embodiment,
Preferably, bioreactor 1 is four, and it is placed side by side in the locating slot of integrated cabinet 2.Wherein,
The weight of bioreactor 1 is converted into electric signal by pressure sensor by weighing device, and electric signal is passed
To processing equipment 3, when processing equipment 3 receives electric signal, electric signal is transformed into the form of chart aobvious
Show and show on device.
In addition, in the present embodiment, experimenter needs substantial amounts of data to be contrasted, simultaneously in order to just
Check experimental data in experimenter, multi-joint bioreactor system has also installed additional and has been used for storing experimental data
Storage device, storage device is connected with processing equipment 3 by data wire, because storage device is permissible
Store substantial amounts of experimental data so that experimenter can fast and accurately obtain reality by processing equipment 3
Test data and query history record.
Second embodiment of the present invention is related to a kind of multi-joint bioreactor system.As shown in Fig. 2 this
The improvement further to first embodiment for the second embodiment of invention, it is mainly improved by, at this
In embodiment, multi-joint bioreactor system also comprises communication apparatus 8, cloud server 9, moves eventually
End 10.
In actual application, experimenter, due to being responsible for multiple laboratories, needs to each laboratory
Observed, due to experimenter's limited amount it is impossible to accomplish in real time to each bioreactor 1 data
Observed, experimenter understands the related data of experiment whenever and wherever possible for convenience, observed monitoring result,
Present embodiment, it is possible to achieve using the remote monitoring of mobile terminal 10.
Further, the experimental data that bioreactor 1 obtains, prison will be monitored by monitoring device 5
Survey device 5 and experimental data is passed to processing equipment 3 by data wire, because processing equipment 3 and communication set
Standby 8 are connected by data wire, and the experimental data that processing equipment 3 receives is passed to communication by data wire and set
Standby 8, the experimental data being monitored is uploaded in cloud server 9 final communication apparatus 8 in real time,
Experimenter by mobile phone wireless signal-obtaining or can download the up-to-date experiment number in cloud server 9
According to by the up-to-date experimental data of reading or download by the screen display of mobile phone out, as experiment people
When member needs the Laboratory Monitoring data monitoring a certain moment, only need to open mobile phone, experimental data is just permissible
It is clearly shown on mobile phone screen, within the shortest time, bioreactor 1 is monitored, quick acquisition
Accurately experimental data display on same interface, facilitate experimenter's observed data result and its change
Change, draw the condition of culture of optimum.It should be noted that in the present embodiment, in order to realize taking
Band property, the mobile device that mobile terminal 10 can be for mobile phone or panel computer with screen.
It will be understood by those skilled in the art that the respective embodiments described above are to realize the tool of the present invention
Body embodiment, and in actual applications, can to it, various changes can be made in the form and details, and not
Deviate the spirit and scope of the present invention.
Claims (9)
1. a kind of multi-joint bioreactor system is it is characterised in that comprise：One integrated cabinet, one
Processing equipment, N are set on the biological respinse monitoring device on described integrated cabinet, N >=2 and N is nature
Number；
Described biological respinse monitoring device comprise for cultivate microorganism bioreactor, be used for monitoring
The monitoring device of described bioreactor；
Described each monitoring device is electrically connected with described processing equipment and by the experimental data being monitored
Send to described processing equipment；
Described processing equipment comprises display, and shows described each monitoring on the display simultaneously
The experimental data that device is monitored.
2. multi-joint bioreactor system according to claim 1 is it is characterised in that described many
Connection bioreactor system also comprises the storage device for storing described experimental data, described storage device
It is electrically connected with described processing equipment.
3. multi-joint bioreactor system according to claim 1 is it is characterised in that described many
Connection bioreactor system also comprises communication apparatus, cloud server, mobile terminal, described processing equipment
It is electrically connected with described communication apparatus and by described communication apparatus, the experimental data being monitored is uploaded to
In described cloud server, described mobile terminal is read by wireless signal or downloads described cloud server
In experimental data.
4. multi-joint bioreactor system according to claim 3 is it is characterised in that described shifting
Dynamic terminal is mobile phone and/or panel computer.
5. multi-joint bioreactor system according to claim 1 is it is characterised in that described collection
Cabinet is become to be provided with the locating slot coordinating described bioreactor, described each bioreactor is located at described respectively
In each locating slot.
6. multi-joint bioreactor system according to claim 5 is it is characterised in that described prison
Survey device and comprise the weighing device for weighing described bioreactor weight；
Described each weighing device be separately positioned on described each positioning trench bottom and respectively with described processing equipment
It is electrically connected with.
7. multi-joint bioreactor system according to claim 1 is it is characterised in that described collection
Cabinet surface is become to be provided with attachment material source, water source, power supply, the line concentration quick union of source of the gas respectively, described
The material pipeline of each bioreactor, water pipeline, electric line, gas pipeline are connect soon with described line concentration respectively
Head connects.
8. multi-joint bioreactor system according to claim 1 is it is characterised in that described collection
Become to be fixed with cabinet and coordinate the pipeline of described bioreactor, pump, instrument, electric controling element.
9. multi-joint bioreactor system according to claim 1 is it is characterised in that described collection
The lower section becoming cabinet is provided with roller.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610389013.1A CN106399074A (en) | 2016-06-02 | 2016-06-02 | Multiplex bioreactor system |
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| CN201610389013.1A CN106399074A (en) | 2016-06-02 | 2016-06-02 | Multiplex bioreactor system |
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| CN106399074A true CN106399074A (en) | 2017-02-15 |
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| CN201610389013.1A Pending CN106399074A (en) | 2016-06-02 | 2016-06-02 | Multiplex bioreactor system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021240016A3 (en) * | 2020-05-29 | 2022-01-13 | Univercells Technologies Sa | System and method for the production of biomolecules |
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| WO2021240016A3 (en) * | 2020-05-29 | 2022-01-13 | Univercells Technologies Sa | System and method for the production of biomolecules |
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