CN106392332B - A kind of laser-graining method for improving medical implant surfaces cell adhesion - Google Patents
A kind of laser-graining method for improving medical implant surfaces cell adhesion Download PDFInfo
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- CN106392332B CN106392332B CN201610887356.0A CN201610887356A CN106392332B CN 106392332 B CN106392332 B CN 106392332B CN 201610887356 A CN201610887356 A CN 201610887356A CN 106392332 B CN106392332 B CN 106392332B
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- medical implant
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/36—Removing material
- B23K26/361—Removing material for deburring or mechanical trimming
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/60—Preliminary treatment
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/70—Auxiliary operations or equipment
Abstract
The invention discloses a kind of laser-graining methods for improving medical implant surfaces cell adhesion：(1), it carries out chemical cleaning successively to medical material surface to deoil, be cleaned again after mechanical grinding polishing or laser polishing；(2), the medical material after step (1) is cleaned is placed on the workbench of laser-processing system; set laser parameter; start laser-processing system; laser is made to be strafed on medical material surface with certain speed using vibration mirror scanning; the texturizing surfaces that laser ablation obtains finally are obtained on surface, process carries out under inert gas shielding；(3), the medical material after processing is cleaned.This method can be widely used in the medical implant of special-purpose by the method for the present invention, and the surface of implantation material is made to obtain better cell adherence performance, improves the medical effect of implantation material.
Description
Technical field
The present invention relates to a kind of laser-graining methods for improving medical implant surfaces cell adhesion.It can be by this method
It is widely used in the medical implant of special-purpose, the surface of implantation material is made to obtain better cell adherence performance, improves implantation
The medical effect of object belongs to material surface processing technique field.
Background technology
Short pulse laser technology with the feature of its ultrahigh peak power density, Superfast time resolution and high focusing power,
Medicine, microelectronics, micro-/multiple fields such as processing and material science of receiving are widely used.Short-pulse laser is micro-/receive plus
Work technology gradually takes by significant advantages such as its high machining resolution, minimum heat affected area and higher processing qualities
For traditional processing technology become solid material it is micro-/receive processing one of most efficient method.Short-pulse laser surface micro-/ nano line
Physics and chemistry be short-pulse laser it is micro-/receive the important applied field of manufacture, be the weight for preparing the functional material with special surface properties
Want method.An important factor for surface topography is the performances such as control solid material surface optics, wetting, chemistry, biology, mechanics.It adopts
A variety of microns, nano-scale structures can be prepared in material surface with short-pulse laser surface micro/nano structure technology, so as to change
Become the performances such as material surface optics, wetting, preparation such as superelevation light absorption, super-hydrophobic, automatically cleaning, corrosion protection, antifreeze, fungi-proofing, low
There is important application prospect on the surfaces such as flow resistance in fields such as sensor, solar collector, turbo blade, wing, radar communications.
The material surfaces microscopic appearance such as medical material, polymer has been demonstrated that growth feelings of the cell on its surface can be influenced
Condition, specific influencing mechanism is not completely clear and definite, but existing experiment confirms：Relative to even curface, surface irregularity it is micro-
Direction orientation of certain cells when material surface is grown, growth form, coverage rate etc. can be influenced by seeing structure.Using short
The method of pulse laser ablation can realize accurate texurization process to material surface, the material that makes that treated realize it is specific will
The cell adherence effect asked.
Invention content
The purpose of the present invention is to provide a kind of laser-graining methods for improving medical implant surfaces cell adhesion.
This method can be widely applied to the surface treatment of medical implant, and the cell adherence that making medical implant has particular requirement is imitated
Fruit.
A kind of flow such as Fig. 1 institutes for the laser-graining method for improving medical implant surfaces cell adhesion of the present invention
Show, mainly include the following steps：
(1) chemical cleaning is carried out successively to medical material surface to deoil, it is clear again after mechanical grinding polishing or laser polishing
It washes；
(2) medical material after step (1) is cleaned is placed on the workbench of laser-processing system, sets laser parameter,
Start laser-processing system, laser is made to be strafed on medical material surface with certain speed using vibration mirror scanning, finally obtained on surface
The texturizing surfaces that laser ablation obtains are obtained, process carries out under inert gas shielding；
(3) medical material after processing is cleaned.
Wherein, the medical material can be magnesium alloy, titanium alloy, steel, high molecular polymer；
Wherein, the laser parameter set in step (2) as：Optical maser wavelength is 193nm~1070nm, laser pulse width 50fs
~100ns, laser power are 1W~50W, and laser pulse frequency is 1kHz~1MHz；
Wherein, laser is made to be strafed on medical material surface with certain speed using vibration mirror scanning in step (2), speed is
0.2mm/s~3m/s.
Wherein, as shown in figure 3, making the line that laser is obtained in medical material ablated surface using vibration mirror scanning in step (2)
The microscopic appearance on physics and chemistry surface can be pit array, at a certain angle groove structure arranged in parallel, the staggered row of certain depth
The groove structure thrin of row, recess width are 1~500 μm, and groove spacing is 0~500 μm, and pit diameter can be 1~500
μm, pit spacing is 0~500 μm, and groove and pit depth are 1~100 μm.
A kind of laser-graining method for improving medical implant surfaces cell adhesion disclosed by the invention, opens one
The new medical material surface treatment method of kind, relative to original material surface, makes material surface regional area exist using laser
Moment is heated to quite high temperature and ablation, and material surface is made to form specific veining pattern according to being pre-designed, with
Reaching improves the cell adherence performance on Medical implants surface, is carved compared to untreated medical implant surfaces or machinery
The surface indentation drawn, the advantage of the invention is that：
(1)：This method utilizes laser direct writing system, can be by changing laser parameter such as frequency, sweep speed, power pair
Medical material ablated surface depth, track etc. are accurately controlled, and can obtain machining accuracy and the range of work much larger than existing
Reinforcement process.
(2)：This method utilizes laser direct writing system, and hardening is based on material at high temperature ablation, and heat affecting is small, processed material
Chemical change does not occur for matrix, can be applied to a variety of medical material materials.
(3)：This method process velocity faster, is expected to improve production efficiency in actual production.
Description of the drawings：
Fig. 1 show the method for the present invention flow chart.
Fig. 2 show laser-processing system schematic diagram.
Fig. 3 a, Fig. 3 b, Fig. 3 c show material surface pattern schematic diagram after laser surface strengthening.
Specific embodiment：
In the following with reference to the drawings and specific embodiments, the invention will be further described.
As shown in the figure, a kind of laser-graining side for improving medical implant surfaces cell adhesion disclosed by the invention
Method, as shown in Figure 1, specifically including following steps：
Deoil 1. pair medical material material surface carries out chemical cleaning successively, mechanical grinding polishing or laser polishing again after
Cleaning；
2. the medical material after step 1 is cleaned is placed on the workbench of laser-processing system, laser parameter is set, is started
Laser-processing system is made laser be strafed on medical material surface with certain speed, is finally swashed on surface using vibration mirror scanning
The texturizing surfaces that light ablation obtains, process carry out under inert gas shielding；
3. the medical material after pair processing cleans.
Wherein, the medical material can be magnesium alloy, titanium alloy, steel, high molecular polymer；
Wherein, the laser parameter set in step (2) as：Optical maser wavelength is 193nm~1070nm, laser pulse width 50fs
~100ns, laser power are 1W~50W, and laser pulse frequency is 1kHz~1MHz；
Wherein, laser is made to be strafed on medical material surface with certain speed using vibration mirror scanning in step (2), speed is
0.2mm/s~3m/s.
Wherein, as shown in figure 3, making the line that laser is obtained in medical material ablated surface using vibration mirror scanning in step (2)
The microscopic appearance on physics and chemistry surface is the pit array of certain depth, groove structure arranged in parallel, staggered at a certain angle
Groove structure thrin, recess width are 1~500 μm, and groove spacing is 0~500 μm, and pit diameter can be 1~500 μm,
Groove and pit depth are 1~100 μm.
Embodiment 1：
(1)：The TC4 titanium alloy pieces of 2mm thickness are taken, is placed in absolute alcohol and cleans, are cleaned again after mechanical grinding polishing.
(2)：By sample be placed in picosecond laser system of processing as shown in Figure 2 (use 1060nm wavelength optical fiber laser,
Pulsewidth 300ps) workbench on, setting laser power be 15W, frequency 500KHz, sweep speed 200mm/s, scan line
Spacing is 40 μm, and setting Scanning size is 15mm × 15mm, and scanning number of repetition is 5 times, starts laser-processing system and opens
Begin to process.
(3)：Titanium alloy block after processing is removed from workbench, is wiped and cleared up with absolute alcohol.
Embodiment 2：
(1)：The 316L stainless steel substrates of 2mm thickness are taken, is placed in absolute alcohol and cleans, it is clear again after mechanical grinding polishing
It washes.
(2)：By sample be placed in picosecond laser system of processing as shown in Figure 2 (use 1060nm wavelength optical fiber laser,
Pulsewidth 300ps) workbench on, setting laser power be 20W, frequency 100KHz, sweep speed 3000mm/s, scan line
Spacing is 70 μm, and setting Scanning size is 15mm × 15mm, and scanning number of repetition is 5 times, starts laser-processing system and opens
Begin to process.
(3)：Titanium alloy block after processing is removed from workbench, is wiped and cleared up with absolute alcohol.
Embodiment 3：
(1)：The Ni-Ti alloy sheets of 2mm thickness are taken, is placed in absolute alcohol and cleans, cleaned again after laser polishing.
(2)：Sample is placed in nanosecond laser system of processing as shown in Figure 2 and (uses the Nd of 532nm wavelength:YAG laser
Device, pulsewidth 34ns) workbench on, setting laser power be 30W, frequency 10KHz, sweep speed 500mm/s, scan line
Spacing is 100 μm, and setting Scanning size is 15mm × 15mm, and scanning number of repetition is 5 times, starts laser-processing system and opens
Begin to process.
(3)：Step 2 will be repeated after 90 degree of sample transposition.
(4)：Alloy sheet after processing is removed from workbench, is wiped and cleared up with absolute alcohol.
The technical means disclosed in the embodiments of the present invention is not limited to the technical means disclosed in the above technical means, and is further included
By more than technical characteristic arbitrarily the formed technical solution of combination.The scope of protection of present invention is defined with claims
Subject to range.
Claims (5)
1. a kind of laser-graining method for improving medical implant surfaces cell adhesion, is characterized in that：Include the following steps：
(1), it carries out chemical cleaning successively to medical material surface to deoil, be cleaned again after mechanical grinding polishing or laser polishing；
(2), the medical material after step (1) is cleaned is placed on the workbench of laser-processing system, sets laser parameter, is started
Laser-processing system is made laser be strafed on medical material surface with certain speed, is finally swashed on surface using vibration mirror scanning
The texturizing surfaces that light ablation obtains, process carry out under inert gas shielding；
(3), the medical material after processing is cleaned；
The laser parameter set in the step (2) as：Optical maser wavelength be 193nm~1070nm, laser pulse width for 50fs~
100ns, laser power are 15W~50W, and laser pulse frequency is 100kHz~1MHz.
2. a kind of laser-graining method for improving medical implant surfaces cell adhesion according to claim 1,
It is characterized in that：Laser is made to be strafed on medical material surface with certain speed using vibration mirror scanning in the step (2), speed is
0.2mm/s~3m/s.
3. a kind of laser-graining method for improving medical implant surfaces cell adhesion according to claim 1,
It is characterized in that：The medical material can be magnesium alloy, titanium alloy, steel, high molecular polymer.
4. a kind of laser-graining method for improving medical implant surfaces cell adhesion according to claim 1,
It is characterized in that：Make the texturizing surfaces that laser obtained in medical material ablated surface using vibration mirror scanning in the step (2)
Microscopic appearance is the pit array of certain depth, groove structure arranged in parallel, groove structure three staggered at a certain angle
One of person.
5. a kind of laser-graining method for improving medical implant surfaces cell adhesion according to claim 4,
It is characterized in that：The recess width is 1~500 μm, and groove spacing is 0~500 μm, and pit diameter is 1~500 μm, between pit
Away from being 0~500 μm, groove and pit depth are 1~100 μm.
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10966863B2 (en) * | 2018-01-08 | 2021-04-06 | EyeYon Medical Ltd. | Treatment to improve adhesive properties of corneal implant |
| CN110064104A (en) * | 2018-01-22 | 2019-07-30 | 南京农业大学 | A kind of surface has the medical use needle and preparation method thereof of micro-nano composite antibacterial texture |
| CN108555437A (en) * | 2018-05-09 | 2018-09-21 | 北京航空航天大学 | A kind of laser processing of orientation regulation and control biomedical metal material superficial cell growth |
| CN108754372A (en) * | 2018-06-13 | 2018-11-06 | 北京航空航天大学 | A kind of laser processing method improving magnesium alloy biocompatibility |
| US20220001081A1 (en) * | 2018-08-27 | 2022-01-06 | Ossio Ltd. | Surface treated biocomposite material, medical implants comprising same and methods of treatment thereof |
| CN109079446A (en) * | 2018-09-20 | 2018-12-25 | 北京航空航天大学 | A method of preparing antimicrobial surface on the medical instrument |
| CN111979501B (en) * | 2020-08-18 | 2021-09-24 | 新沂市锡沂高新材料产业技术研究院有限公司 | High-antibacterial-property medical metal glass and preparation method thereof |
| CN113798678A (en) * | 2021-10-18 | 2021-12-17 | 北京航空航天大学 | Method for inducing high-bioactivity surface of oral titanium alloy implant by laser |
| CN114769623B (en) * | 2022-06-20 | 2022-09-02 | 吉林大学 | Preparation method for manufacturing NiTi alloy super-hydrophilic surface by additive manufacturing |
| CN114769613B (en) * | 2022-06-21 | 2022-09-02 | 吉林大学 | Preparation method for manufacturing NiTi alloy super-hydrophobic surface through additive manufacturing |
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| JP2670420B2 (en) * | 1993-11-18 | 1997-10-29 | 株式会社吉田製作所 | Laser cutting equipment |
| US20040000540A1 (en) * | 2002-05-23 | 2004-01-01 | Soboyejo Winston O. | Laser texturing of surfaces for biomedical implants |
| DE10252529B3 (en) * | 2002-11-08 | 2004-08-19 | Rheinisch-Westfälisch- Technische Hochschule Aachen | Medical/dental hand instrument, for coating surfaces with a protective layer, has a ring jet for a flow of particles and a laser beam to deposit a molten flow on the surface |
| WO2007096484A2 (en) * | 2006-02-23 | 2007-08-30 | Picodeon Ltd Oy | Coating with carbon nitride and carbon nitride coated product |
| CN103200968B (en) * | 2010-10-29 | 2016-09-14 | 三菱电机株式会社 | Embedded material, implantation parts, implantation component manufacturing method, laser processing and laser processing device |
| CN104127911B (en) * | 2014-07-21 | 2015-11-11 | 华中科技大学 | A kind of take titanium alloy as the Biocomposite material preparation method of implantation body |
| CN104083802B (en) * | 2014-07-23 | 2015-08-05 | 江苏大学 | Improve the method for medical magnesium alloy surface medical bio anchoring strength of coating |
| CN104439956B (en) * | 2014-11-18 | 2017-04-19 | 清华大学 | Method for connecting materials difficult to connect through ultrafast lasers |
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