CN106389962A - Traditional Chinese medicinal composition for preventing and treating lamb colibacillosis, and preparation method and application thereof - Google Patents
Traditional Chinese medicinal composition for preventing and treating lamb colibacillosis, and preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicinal composition for preventing and treating lamb colibacillosis. The traditional Chinese medicinal composition for preventing and treating the lamb colibacillosis is prepared from the following components in parts by weight: 200+/-20 parts of radix pulsatilla, 100+/-10 parts of taraxaci herba, 100+/-10 parts of purslane herb, 180+/-10 parts of fructus evodiae, 100+/-10 parts of pericarpium papaveris, 60+/-5 parts of schisandrae chinensis fructus, 100+/-10 parts of charred hordei fructus germinatus, charred fructus crataegi and charred medicated leaven, 100+/-10 parts of poria cocos, and 60+/-5 parts of prepared liquorice roots. The invention also provides a preparation method and application thereof. The traditional Chinese medicinal composition for preventing and treating the lamb colibacillosis, and the preparation method and the application thereof have the advantages and beneficial effects that: 1, traditional Chinese medicine and veterinary medicine treatment methods and pure traditional Chinese components are adopted, a lamb is cured quickly after taking the above traditional Chinese medicines orally, and the traditional Chinese medicinal composition does not have a side effect and is beneficial to the growth of the lamb; 2, the traditional Chinese medicinal liquid disclosed by the invention is easy to blend, convenient to use and low in raw material cost, does not have toxic reaction after being used, is high in cure rate, does not have residue, and is an ideal medicine for preventing and treating the lamb colibacillosis.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, more particularly to a kind of Chinese medicine composition of preventing and treating lamb colibacillosiss
And its preparation method and application.
Background technology
Lamb colibacillosiss, also known as lamb coliform diarrhea or lamb Hakuri, are to be drawn by angstrom Xi Shi escherichia coli
A kind of acute infectious disease rising.This disease occurs, undernutrition, sheep hurdle poor with climatic environment humidity, hygienic conditions poor etc., and factor has
Close, this disease the most easily occurs during winter-spring season drylot feeding.Generally this cause of disease lamb resistance declines, and has licked the ewe milk of pollution
Head, utensil, article etc., pathogenic bacteria by stomach reach intestinal, amount reproduction in intestinal and cause enteric cavity liquid to gather in a large number, make intestinal
Chamber is expanded, and stimulates enterokinesia, causes diarrhoea, finally leads to death because dehydration, acidosis and electrolyte balance are disorderly.
The morbidity initial lassitude of lamb, appetite substantially goes down, and conjunctiva flushing, abdominal distention, grinds one's teeth in sleep, groan.Afterwards, arrange loose stool
Just it is in yellow pasty state, in indivedual sick sheep feces, carries mucus, blood or puss, in several cases feces, carry intestinal mucosa.Great majority
The sick sheep of symptom of diarrhea occurs, tail has edema phenomenon, indivedual ears edema.Clinically often it is divided into septic and enteritis type（Again
Claim dysentery type）Two kinds of pattern of syndrome.
Septic：Regular incidence is in the lamb of 2～3 week old.Sick sheep shows as lassitude, weakness, drowsiness, Kou Liupao
Foam, nose stream mucus, there is slight symptom of diarrhea, body temperature raises and reaches 41 DEG C～42 DEG C.Engender cranial nerve with PD
Symptom, visual disorder, blindly walk, head bends towards side and does circus movement, the behavior of grade of lurching, typically 2 after sick sheep is fallen ill
Dead in it or a couple of days.
Enteritis type（Also known as dysentery type）：The multiple newborn lamb being born in 2～8 ages in days.Sick sheep initial stage body temperature is usually increased to
41 DEG C about, after diarrhoea, body temperature can gradually decrease down normally, and originally feces are in light yellow, become atherosclerotic, are often accompanied by stench
Taste, develops into water sample canescence, the feces containing curdling block sample then, sometimes with the blood streak and foam, generally ill lamb anus
Door incontinence, pollution rear-guard and leg, show as extremely painful during defecation.When serious dehydration symptom in lamb, typically through 1
～3 days dead.
Primary disease has a strong impact on the growth promoter of lamb.Therefore, in production practices, the preventing and treating of lamb colibacillosiss should be by
It is considered as the most important thing of sheep raising Disease Prevention work.Lamb colibacillosiss, at present clinically mainly using antibiotic therapy, resist
Although raw element can suppress or kill many Escherichia coli, body intestinal in addition to Escherichia coli, also
Substantial amounts of non-pathogenic flora, they have very important effect to the eubolism of body, blindly using antibiotic
Also will suppress or kill many non-pathogenic floras, and destroy it and form structure, and have a strong impact on the digestive function of body and increase
The state of an illness；In addition it is also easy to produce Drug resistance using antibiotic in a large number for a long time.Abuse chemical medicine, antibiotic and monomer medicine, both produced without restraint
Polynary drug resistance and the super many drug-induced disease such as quick of receptor, cause animal products to pollute again, jeopardize human food's safe and sanitary.In
Medicine derives from animal, plant and mineral, and containing multiple biological effective components, wherein most of Chinese medicines are to be former with natural plants
Material, aboundresources, easily obtain, respond well, cheap, toxic and side effects are small, almost noresidue, no Drug resistance, not dirty
Dye environment.Therefore, substitute chemical medicine from Chinese medicine preparation, antibiotic is particularly important.
Content of the invention
The technical problem to be solved in the present invention is to overcome existing defect, there is provided a kind of cure rate is high, toxic and side effects are little,
It is not likely to produce the Chinese medicine composition of the preventing and treating lamb colibacillosiss of drug resistance；The present invention also provides its preparation method and application.
First purpose of the present invention is to provide a kind of Chinese medicine composition of preventing and treating lamb colibacillosiss, by following weight
The component preparation of part completes：200 ± 20 parts of the Radix Pulsatillae；100 ± 10 parts of Herba Taraxaci；100 ± 10 parts of Herba Portulacae；Fructus Evodiae 180 ±
10 parts；100 ± 10 parts of Pericarpium Papaveriss；60 ± 5 parts of Fructus Schisandrae Chinensis；100 ± 10 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)；100 ± 10 parts of Poria；Radix Glycyrrhizae Preparata 60 ± 5
Part.
Preferably, being completed by the component preparation of following weight portion：200 ± 10 parts of the Radix Pulsatillae；100 ± 5 parts of Herba Taraxaci；Horse
100 ± 5 parts of bitterroot；180 ± 5 parts of Fructus Evodiae；100 ± 5 parts of Pericarpium Papaveriss；60 ± 2 parts of Fructus Schisandrae Chinensis；100 ± 5 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)；Poria
100 ± 5 parts；60 ± 2 parts of Radix Glycyrrhizae Preparata.
Most preferably, completed by the component preparation of following weight portion：200 parts of the Radix Pulsatillae；100 parts of Herba Taraxaci；Herba Portulacae 100
Part；180 parts of Fructus Evodiae；100 parts of Pericarpium Papaveriss；60 parts of Fructus Schisandrae Chinensis；100 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)；100 parts of Poria；60 parts of Radix Glycyrrhizae Preparata.
Under above-mentioned each optimum condition, the prevention effect of the Chinese medicine composition obtaining steps up.With most preferred condition
Lower prevention effect is optimal.
Second object of the present invention is the preparation method providing above-mentioned Chinese medicine composition, is to mix each component of formula ratio
After conjunction, alcohol extraction is prepared from again for first water extraction.
Preferably, concrete preparation method is：After each component mixing of formula ratio, add 8-12 times of weight of medical material
Water, decocts 2 times, each 90-120 minute, collecting decoction, filtration, and filtrate standing takes supernatant, and is concentrated into relative density and is
1.00-1.10, plus ethanol to alcohol content 70-75%, places, and filters, reclaims ethanol, adding water to relative density is 1.00-1.10,
Sterilizing, thus obtaining the product；Preferably, alcohol extraction and add water to relative density be 1.00-1.10 after, add antifungus agent, such as add calcium propionate
2g/kg medicinal liquid or potassium sorbate 2g/kg medicinal liquid.
Third object of the present invention is to provide above-mentioned Chinese medicine composition in preparation prevention and/or treatment lamb escherichia coli
Application in the medicine of disease.
Fourth object of the present invention is to provide a kind of medicine, and the effective ingredient of described medicine is above-mentioned Chinese medicine composition
Thing.
Preferably, described medicine also includes medically acceptable adjuvant.
Preferably, the dosage form of described medicine is oral liquid.
Preferably, the using method of described medicine is：Therapeutic dose：Lamb, 1-3ml/kg BW, 1 time/d, be used in conjunction 5-7
My god；Preventive dose：Lamb, 2ml/kg BW, 1 time/d, be used in conjunction 5-7 days.
Lamb diarrhoea is multiple to be born in spring autumn and winter, lamb weakness of the spleen and stomach, and transportation capabilities are not strong, and mostly has greedy cool and enter
Situations such as scavenging sour food, therefore caused by thinking primary disease mainly due to experiencing the foul gas of cold-damp and unhygienic diet.Chinese veterinarian thinks
It is young that the generation of primary disease is mainly (1) lamb, weakness of the spleen and stomach, transportation capabilities strong it is impossible to received water paddy and transporting precise and tiny, water paddy
Stagnate, clear QI being mixed up with turbid QI, mix and under, then become have loose bowels.As《Jing Yue's complete work is had loose bowels》A piece is so-called：" have loose bowels originally, invariably due to spleen
Stomach ".(2) experience seasonal pathogen：In the season of autumn and winter, damp is rising, if it is inappropriate to take good care of oneself, experiences the foul pestilential pathogen of cold-damp, or because coveting cool dew
Place, cold-damp invade, exopathogen oxious gas, strongly fragrant hold back middle Jiao, taste all can be made injured, dysfunction of the spleen in transportation and transformation, disorder of QI movement, disorder in ascending and descending, pure and impure
Relevant, disorderly form in the intestines and stomach and have loose bowels.(3) feeding is unclean：Feeding is unclean, enters rotten deteriorating food of turning sour by mistake, or cold and cool feedstuff, energy loss
Imapirment of the spleen and stomach, pure and impure mutually mixing forms.
In sum, mainly because lamb internal organs are tender and lovely, shape gas does not fill or congenital malformation primary disease, and the nutrition day after tomorrow is not
Foot, leads to lamb weakness of the spleen and stomach and resistance to decline, and experiences wet foul gas, and the heresy of cold-damp pyretic toxicity is taken advantage of a weak point in opponent's defence and invaded taste, noxious dampness
Tired spleen, deficiency of spleen-QI and stomach-QI, hypoactivity of YANG in middle-JIAO, and cause mechanism of qi to stagnate, rise sending down the abnormal ascending QI disorderly, spleen main fortune transporting and sending up the lucid YANG, stomach receiving food and drink and drop
Turbid yin, in the present, void has cold, lifting dereliction of duty, therefore is lower profit stomachache, loss of appetite；There is obstacle in the digestive and absorptive functions of taste, clearly
Turbid regardless of mix and under, damp and hot tenesmus, intestine and small intestine is secreted and is not neglected one's duty, and water is wet a point profit can not to be formed and have loose bowels, therefore excrement is dilute, stench, or poison
In stagnant intestinal, so that intestinal QI and blood is blocked, turn to pus in vain, therefore dysentery color is white or band pus are white.Control suitable heat-clearing and toxic substances removing, promoting the circulation of blood dysentery relieving, convergence
Astringent or styptic treatment for spontaneous sweating, invigorating the spleen for eliminating dampness, stomach function regulating antidiarrheal.
Medicine of the present invention is to use Radix Pulsatillae heat clearing and damp drying, removing pathogenic heat from blood and toxic substance from the body, Herba Taraxaci heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, two medicines
Demonstrate,prove monarch drug for treating this.Herba Portulacae has functions that heat-clearing and toxic substances removing, dissipates blood detumescence, can control hematodiarrhoea pus and blood；Pericarpium Papaveriss relieving diarrhea with astringents,
Pain relieving；Fructus Schisandrae Chinensis sour in the mouth restrains relieving diarrhea with astringents, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) spleen benefiting and stimulating the appetite, promoting digestion and removing stagnation, removing dampness of inducing sweat, and promoting the circulation of qi helps digestion, spleen invigorating are opened
Stomach, wet antidiarrheal is transported in Poria spleen invigorating, and above five medicines are ministerial drug altogether.Fructus Evodiae pungent-warm cold expelling, warm liver stomach warming, the medicine preventing and treating bitter cold is upset one's stomach
The disadvantage of impairment of YANG, is for using corrigent.Radix Glycyrrhizae Preparata QI invigorating and middle emergency, and the poison of all medicines can be solved, and the pungent strong property of all medicines can be relaxed for making,
All medicines share, treating both the principal and secondary aspects of a disease, and healthy energy is unobstructed, then heresy is inverse removes certainly.
Medicine of the present invention is formed by traditional Chinese drug inspissations such as the Radix Pulsatillae, Herba Taraxaci, Herba Portulacae, Pericarpium Papaveriss, with invigorating the spleen to clear away damp pathogen, stomach function regulating
Removing toxic substances effects a permanent cure, promoting the circulation of blood dysentery relieving, the purpose that convergence is astringent or styptic treatment for spontaneous sweating, stomach function regulating antidiarrheal reaches treatment lamb colibacillosiss.The abundant reference of prescription
Chinese veterinarian's eight guiding principles for diagnosis, determining the pathogenesis of ZANG-FU disease based on the differentiation of symptoms and signs are theoretical, giving consideration to both the exterior and interior, and, with controlling, with YAOJING specially, compatibility is careful and precise, embodies medication and such as uses military forces for QI and blood,
The road used military forces is essence, and the road of medication is pure prescription characteristic.
Modern veterinary's pharmacological research and clinical prolonged application, it was verified that Chinese medicine has overall curative effect height, are not likely to produce
Drug resistance, residual is low, and the advantages of toxic and side effects are little, it has significant suppression to the growth of many bacteria pathogenies with breeding and makees
With even up to killing the pharmacological effect of cause of disease.The present invention according to lamb colibacillosiss the cause of disease, pathogenesis, clinical
Pathology and drug mechanism, carry out Chinese medicine compound preventing and treating lamb colibacillosiss, develop evident in efficacy, quality can
Lean on, apply convenient, cheap compound Chinese medicinal preparation, and popularization and application in sheep raising produces, it is good for for promoting sheep husbandry
Kang Fazhan has highly important economy and social meaning.
Advantages of the present invention and having the beneficial effect that：1st, the present invention adopts traditional Chinese medical science veterinary treatment, using pure Chinese medicine component, is administered orally
Following traditional Chinese medicines, lamb is cured soon after eating, and has no side effect, is conducive to the growth of lamb.2nd, the traditional Chinese medicine liquid modulation letter of the present invention
Single, easy to use, low raw-material cost, with rear non-toxic reaction, cure rate be also high, noresidue, is a kind of preferably to prevent and treat lamb
The medicine of sheep colibacillosiss.
The medicine of the present invention can directly gavage for lamb when specifically used.
The usage amount of the medicine of the present invention is：Therapeutic dose：Lamb, 1-3ml/kg BW（Optimum is 2ml/kg BW）、1
Secondary/d, it is used in conjunction 5-7 days；Preventive dose：Lamb, 2ml/kg BW, 1 time/d, be used in conjunction 7d.
Specific embodiment
Below example facilitates a better understanding of the present invention, but does not limit the present invention.Experiment in following embodiments
Method, if no special instructions, is conventional method.Test material used in following embodiments, if no special instructions, is city
Sell.
A kind of Chinese medicine composition of preventing and treating lamb colibacillosiss of the present invention, has been prepared by the component of following weight portion
Become：
200 ± 20 parts of the Radix Pulsatillae；100 ± 10 parts of Herba Taraxaci；100 ± 10 parts of Herba Portulacae；180 ± 10 parts of Fructus Evodiae；Pericarpium Papaveriss 100
± 10 parts；60 ± 5 parts of Fructus Schisandrae Chinensis；100 ± 10 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)；100 ± 10 parts of Poria；60 ± 5 parts of Radix Glycyrrhizae Preparata.
The preparation method of the Chinese medicine composition of preventing and treating lamb colibacillosiss of the present invention, comprises the following steps：
Take each component, the water of dosing 8-12 times of weight of material by weight, decoct 2 times, each 90-120 minute, collecting decoction,
Filtration, filtrate stands 12 hours, takes supernatant concentration to relative density to be 1.00～1.10, plus ethanol is to alcohol content 70-75%,
Place, filtration, reclaim ethanol, adding water to relative density is 1.00～1.10, adds calcium propionate 2g/kg medicinal liquid or potassium sorbate
2g/kg medicinal liquid, is mixed, and cools down 24h, filtration brown aseptic polyester bottles subpackage, 100 DEG C of flowing steam 50-60 minutes, obtains final product.
The usage amount of the medicine of the present invention is：Therapeutic dose：Lamb, 1-3ml/kg BW（Optimum is 2ml/kg BW）、1
Secondary/d, it is used in conjunction 5-7 days；Preventive dose：Lamb, 2ml/kg BW, 1 time/d, be used in conjunction 7d.
The Chinese medicine composition preparing within the above range all can effectively prevent and treat lamb colibacillosiss, takes above-mentioned
In the case of amount and Time of Administration, high dose（3ml/kg·BW）Cure rate more than 88.4%, middle dosage（2ml/kg·BW）
Cure rate more than 85.6%, low dosage（1ml/kg·BW）Cure rate more than 71.3%；In above-mentioned dose and taking
In the case of time, the sickness rate of middle dosage prevention group lamb colibacillosiss is less than 5%, and prevention group gives to treat after morbidity
Afterwards, cure rate is more than 84%.
It is below several preferred embodiments, wherein optimal with the therapeutic effect of the Chinese medicine preparation of embodiment 1 preparation.
Embodiment 1
A kind of formula of the Chinese medicine composition of preventing and treating lamb colibacillosiss of the present invention is as follows：
Radix Pulsatillae 200g；Herba Taraxaci 100 g；Herba Portulacae 100 g；Fructus Evodiae 180 g；Pericarpium Papaveriss 100 g；Fructus Schisandrae Chinensis 60 g；Burnt
Hydrargyri Oxydum Rubrum 100 g；Poria 100 g；Radix Glycyrrhizae Preparata 60 g.
A kind of preparation method of the Chinese medicine composition of preventing and treating lamb colibacillosiss of the present invention is：
Weigh each component of formula ratio, the water of 8 times of weight of dosing material, decoct 2 times, 90 minutes every time, collecting decoction, filtration, filter
Liquid stands 12 hours, takes supernatant concentration to relative density to be 1.05, plus ethanol, to alcohol content 70%, is placed, filtration, reclaims second
Alcohol, adding water to relative density is 1.05, adds calcium propionate 2g/kg medicinal liquid, is mixed, and cools down 24h, the filtration aseptic polyester bottles of brown
Subpackage, 100 DEG C of flowing steams 50 minutes, obtain final product.
Embodiment 2
A kind of formula of the Chinese medicine composition of preventing and treating lamb colibacillosiss of the present invention is as follows：
Radix Pulsatillae 210g；Herba Taraxaci 95g；Herba Portulacae 95g；Fructus Evodiae 185g；Pericarpium Papaveriss 95g；Fructus Schisandrae Chinensis 62g；JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 105g；
Poria 95g；Radix Glycyrrhizae Preparata 58g.
A kind of preparation method of the Chinese medicine composition of preventing and treating lamb colibacillosiss of the present invention is：
Take each component by weight, the water of 10 times of weight of dosing material, decoct 2 times, 100 minutes every time, collecting decoction, filtration,
Filtrate stands 12 hours, takes supernatant concentration to relative density to be 1.00, plus ethanol, to alcohol content 75%, is placed, filtration, reclaims
Ethanol, adding water to relative density is 1.00, adds potassium sorbate 2g/kg medicinal liquid, is mixed, and cools down 24h, and filtration is aseptic poly- with brown
Ester bottle subpackage, 100 DEG C of flowing steams 60 minutes, obtain final product.
Embodiment 3
A kind of formula of the Chinese medicine composition of preventing and treating lamb colibacillosiss of the present invention is as follows：
Radix Pulsatillae 190g；Herba Taraxaci 105g；Herba Portulacae 105g；Fructus Evodiae 175g；Pericarpium Papaveriss 105g；Fructus Schisandrae Chinensis 58g；JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)
95g；Poria 105g；Radix Glycyrrhizae Preparata 62g.
A kind of preparation method of the Chinese medicine composition of preventing and treating lamb colibacillosiss of the present invention is：
Take each component by weight, the water of 12 times of weight of dosing material, decoct 2 times, 120 minutes every time, collecting decoction, filtration,
Filtrate stands 12 hours, takes supernatant concentration to relative density to be 1.10, plus ethanol, to alcohol content 72%, is placed, filtration, reclaims
Ethanol, adding water to relative density is 1.10, adds calcium propionate 2g/kg medicinal liquid, is mixed, and cools down 24h, the filtration aseptic polyester of brown
Bottle subpackage, 100 DEG C of flowing steams 50 minutes, obtain final product.
Embodiment 4
A kind of formula of the Chinese medicine composition of preventing and treating lamb colibacillosiss of the present invention is as follows：
Radix Pulsatillae 180g；Herba Taraxaci 110g；Herba Portulacae 110g；Fructus Evodiae 170g；Pericarpium Papaveriss 90g；Fructus Schisandrae Chinensis 55g；JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)
110g；Poria 110g；Radix Glycyrrhizae Preparata 65g.
A kind of preparation method of the Chinese medicine composition of preventing and treating lamb colibacillosiss of the present invention is：
Take each component by weight, the water of 10 times of weight of dosing material, decoct 2 times, 110 minutes every time, collecting decoction, filtration,
Filtrate stands 12 hours, takes supernatant concentration to relative density to be 1.05, plus ethanol, to alcohol content 72%, is placed, filtration, reclaims
Ethanol, adding water to relative density is 1.00, adds potassium sorbate 2g/kg medicinal liquid, is mixed, and cools down 24h, and filtration is aseptic poly- with brown
Ester bottle subpackage, 100 DEG C of flowing steams 52 minutes, obtain final product.
Embodiment 5
A kind of formula of the Chinese medicine composition of preventing and treating lamb colibacillosiss of the present invention is as follows：
Radix Pulsatillae 220g；Herba Taraxaci 90g；Herba Portulacae 90g；Fructus Evodiae 190g；Pericarpium Papaveriss 110g；Fructus Schisandrae Chinensis 65g；JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 90g；
Poria 90g；Radix Glycyrrhizae Preparata 55g.
A kind of preparation method of the Chinese medicine composition of preventing and treating lamb colibacillosiss of the present invention is：
Take each component by weight, the water of 11 times of weight of dosing material, decoct 2 times, 100 minutes every time, collecting decoction, filtration,
Filtrate stands 12 hours, takes supernatant concentration to relative density to be 1.10, plus ethanol, to alcohol content 70%, is placed, filtration, reclaims
Ethanol, adding water to relative density is 1.10, adds calcium propionate 2g/kg medicinal liquid, is mixed, and cools down 24h, the filtration aseptic polyester of brown
Bottle subpackage, 100 DEG C of flowing steams 60 minutes, obtain final product.
Embodiment 6 Application Example
1）Therapeutic test：
The applicant has carried out, using random double blind test method, the lamb colibacillosiss treatment that various dose treats natural occurrence
Test, and be positive drug control group from colistin sulfate injection.Observe the present invention and lamb colibacillosiss are treated and make
With to inquire into the feasibility that it is applied in Production of Livestock and Poultry.
Therapeutic test to the lamb colibacillosiss of natural occurrence：By natural occurrence through clinical diagnosises and laboratory diagnosiss
The sick lamb being diagnosed as lamb colibacillosiss is randomly divided into 5 groups, every group 36.1-3 group is to be made using the embodiment of the present invention 1
Standby medication therapy groups（Set high, medium and low three groups of dosage respectively）；4th group is colistin sulfate injection positive drug control
Group；5th group is positive controls (infection, be not administered).It is individually insulated raising, the symptom of itemized record disease lamb, healing, death
Situations such as.
Medication, administration time：1 group of medicine：Every lamb feeds the medicine 3ml/ of the embodiment of the present invention 1 preparation every time
Kg BW, once a day, even feeds 7 days；2 groups of medicine：Every lamb feeds the medicine 2ml/ of the embodiment of the present invention 1 preparation every time
Kg BW, once a day, even feeds 7 days；3 groups of medicine：Every lamb feeds the medicine 1ml/ of the embodiment of the present invention 1 preparation every time
Kg BW, once a day, even feeds 7 days.Positive drug control group：Every lamb is daily using colistin sulfate injection (normally
Bright book use), it is used in conjunction 7 days；Positive controls：It is not administered.
Experimental result：
After treatment group medicine feed 24h, the spirit of medicine group disease lamb is better than positive controls, counts death toll, medicine after 36 h
The sick lamb of group is substantially fewer than positive controls death toll；Observe after 48h, different degrees of improvement in medicine each group, positive right
Still there is dead successively generation according to group.After 3d, the spirit of medicine group disease lamb, appetite take a favorable turn and (increase from sucking amount, feeding capacity
Go out), feces are normal.After 5d, medicine group disease lamb recovers normal.
Test statistics result shows, in 36 lambs of medicine high-dose therapy group of the present invention, there is 32 recoveries from illness, 4 are still drawn
Dilute, but there is no death, cure rate is 88.9%；In 36 lambs of middle dosage treatment group, there are 31 recoveries from illness, still have loose bowels, but do not have for 5
There is death, cure rate is 86.1%；In 36 lambs of low dose therapy group, there are 26 recoveries from illness, still have loose bowels for 8, dead 2, control
More rate is 72.2%；Colistin sulfate injection for treating group（Matched group）In 36 lambs, there are 26 recoveries from illness, still have loose bowels for 5, and
There are 5 death, cure rate is 72.2%；Positive controls（It is not administered）In 36 lambs, there are 24 still to have loose bowels, and have 12 extremely
Die.High, middle dosage treatment group mortality rate is 0.0%, and treatment group disease lamb, compared with matched group disease lamb, shows as symptom mitigation, disease
Journey shortens, and experiment proves that the high, medium and low dosage of the present invention has therapeutical effect, energy relief of symptoms to lamb colibacillosiss, reduces
Mortality rate, and high, middle dosage is reducing mortality rate, improves the effect that the aspects such as cure rate are superior to colistin sulfate injection.
Effect high, that the middle dosage present invention can reach survival rate of curing the disease, improve, and both zero differences in 0.05 level, therefore face
Bed can adopt middle dosage when using, so not only economic curative effect but also significantly.
2）Prophylactic tria
The Yang Chang occurring in epidemic situation, 120 health lamb that do not fall ill is randomly divided into 2 groups, every group 60, and the 1st group is that medicine is pre-
Anti- group；2nd group is matched group；1st group of every lamb gavages the medicine 2ml/kg BW of the embodiment of the present invention 1 preparation daily, even
Feed 7 days；2nd group without any medicine；Other measure of two groups of lambs is all normally sterilized immune programme for children by Yang Chang.
Result shows：The sickness rate of chemoprophylaxiss group lamb colibacillosiss is 3.0%, and matched group sickness rate is 75.0%,
And the spirit of medicine group morbidity lamb, appetite are all better than matched group, illness symptom is also light compared with matched group.Prevention group is given after morbidity
After treatment, cure rate is 86.0%；And matched group is 67.0%.
From the point of view of result of the test, the present invention has replenishing QI to invigorate the spleen removing dampness, strengthening vital QI to eliminate pathogenic factors, stomach function regulating antidiarrheal, restrains astringent or styptic treatment for spontaneous sweating, removing toxic substances
Arrange turbid, dispersing cold for relieving pain function.Do not find that this medicine has untoward reaction during clinical trial.High, medium and low dosage is big to lamb
Enterobacteria disease disease has preferable therapeutic effect.The therapeutic effect of low dose group is less than high, middle dose group, and middle and high dosage group is dead
Rate, cure rate and the total effective rate aspect of dying there are no significant difference.Should be according to the weight of the state of an illness and treatment cost it is proposed that clinical should
In order to middle and high dosage（Lamb 10-15ml）；Preferably, it is used in conjunction 7 days（For guaranteeing curative effect）.
The medicine of the present invention according to listing terms of packing, in temperature：40 DEG C ± 2 DEG C, relative humidity：Under the conditions of 75% ± 5%
Acceleration study 3 months, quality no significant change.In temperature：25 DEG C of ± 2 DEG C of relative humiditys：Long term test under the conditions of 60% ± 10%
24 months, quality no significant change.Above-mentioned result of the test shows, storage quality is stable under prescribed conditions for the medicine of the present invention.
Finally it should be noted that：The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention,
Although being described in detail to the present invention with reference to the foregoing embodiments, for a person skilled in the art, it still may be used
To modify to the technical scheme described in foregoing embodiments, or equivalent is carried out to wherein some technical characteristics.
All any modification, equivalent substitution and improvement within the spirit and principles in the present invention, made etc., should be included in the present invention's
Within protection domain.
Claims (10)
1. a kind of preventing and treating lamb colibacillosiss Chinese medicine composition it is characterised in that：Prepared by the component of following weight portion
Become：200 ± 20 parts of the Radix Pulsatillae；100 ± 10 parts of Herba Taraxaci；100 ± 10 parts of Herba Portulacae；180 ± 10 parts of Fructus Evodiae；Pericarpium Papaveriss 100
± 10 parts；60 ± 5 parts of Fructus Schisandrae Chinensis；100 ± 10 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)；100 ± 10 parts of Poria；60 ± 5 parts of Radix Glycyrrhizae Preparata.
2. Chinese medicine composition according to claim 1 it is characterised in that：Completed by the component preparation of following weight portion：In vain
200 ± 10 parts of father-in-law of head；100 ± 5 parts of Herba Taraxaci；100 ± 5 parts of Herba Portulacae；180 ± 5 parts of Fructus Evodiae；100 ± 5 parts of Pericarpium Papaveriss；Five
60 ± 2 parts of taste；100 ± 5 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)；100 ± 5 parts of Poria；60 ± 2 parts of Radix Glycyrrhizae Preparata.
3. Chinese medicine composition according to claim 2 it is characterised in that：Completed by the component preparation of following weight portion：In vain
200 parts of father-in-law of head；100 parts of Herba Taraxaci；100 parts of Herba Portulacae；180 parts of Fructus Evodiae；100 parts of Pericarpium Papaveriss；60 parts of Fructus Schisandrae Chinensis；JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)
100 parts；100 parts of Poria；60 parts of Radix Glycyrrhizae Preparata.
4. the arbitrary described Chinese medicine composition of claim 1-3 preparation method it is characterised in that：It is by each component of formula ratio
After mixing, alcohol extraction is prepared from again for first water extraction.
5. preparation method according to claim 4 it is characterised in that：Specifically preparation method is：Each component by formula ratio
After mixing, add the water of 8-12 times of weight of medical material, decoct 2 times, each 90-120 minute, collecting decoction, filtration, filtrate standing takes
Supernatant, and it is concentrated into relative density for 1.00-1.10, plus ethanol, to alcohol content 70-75%, is placed, and filters, reclaims ethanol, add water
It is 1.00-1.10 to relative density, sterilizing, thus obtaining the product；Preferably, alcohol extraction and add water to relative density be 1.00-1.10 after, plus
Enter antifungus agent, such as add calcium propionate 2g/kg medicinal liquid or potassium sorbate 2g/kg medicinal liquid.
6. the arbitrary described Chinese medicine composition of claim 1-3 is in the medicine of preparation prevention and/or treatment lamb colibacillosiss
In application.
7. a kind of medicine it is characterised in that：The effective ingredient of described medicine is the arbitrary described Chinese medicine composition of claim 1-3
Thing.
8. medicine according to claim 7 it is characterised in that：Described medicine also includes medically acceptable adjuvant.
9. the medicine according to claim 7 or 8 it is characterised in that：The dosage form of described medicine is oral liquid.
10. medicine according to claim 9 it is characterised in that：The using method of described medicine is：Therapeutic dose：Lamb, 1-
3ml/kg BW, 1 time/d, be used in conjunction 5-7 days；Preventive dose：Lamb, 2ml/kg BW, 1 time/d, be used in conjunction 5-7 days.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107495090A (en) * | 2017-07-29 | 2017-12-22 | 贵州省华腾农业科技有限公司 | A kind of myotonin deep process |
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| CN103394053A (en) * | 2013-07-18 | 2013-11-20 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition capable of preventing and treating piglet yellow and white scours as well as preparation and applications thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103394053A (en) * | 2013-07-18 | 2013-11-20 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition capable of preventing and treating piglet yellow and white scours as well as preparation and applications thereof |
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| CN107495090A (en) * | 2017-07-29 | 2017-12-22 | 贵州省华腾农业科技有限公司 | A kind of myotonin deep process |
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