CN106389702A - Traditional Chinese medicine for recovering symptoms of gynecological and obstetric surgery and preparation method of traditional Chinese medicine - Google Patents

Traditional Chinese medicine for recovering symptoms of gynecological and obstetric surgery and preparation method of traditional Chinese medicine Download PDF

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CN106389702A
CN106389702A CN201610791950.XA CN201610791950A CN106389702A CN 106389702 A CN106389702 A CN 106389702A CN 201610791950 A CN201610791950 A CN 201610791950A CN 106389702 A CN106389702 A CN 106389702A
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chinese medicine
traditional chinese
radix
recovering
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李琰珉
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Abstract

The invention discloses a traditional Chinese medicine for recovering symptoms of a gynecological and obstetric surgery and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine is prepared from herba saussureae involucratae, crocus sativus, semen pharbitidis, radix salviae miltiorrhizae, radix angelicae sinensis, herb of marginate rockbell, purslane speedwell herb, fructus aurantii, panax notoginseng, folium artemisiae argyi, cortex phellodendri, dried radix rehmanniae, fragrant sarcococca herb, trollius chinensis bunge, radix angelicae, root of gypsophila elegans, scandent schefflera stem and leaf, rhizoma corydalis and sucrose. The traditional Chinese medicine is prepared by the following steps: weighing the various traditional Chinese medicinal raw materials according to proportions; cleaning and drying the raw materials in the air; mixing and crushing the raw materials; decocting the crushed raw materials with the addition of water; conducting reflux extraction twice with the addition of an ethanol solution; combining and filtering extracting solutions, and concentrating a combined extracting solution so as to obtain clear paste; and adding the sucrose and uniformly mixing the materials so as to obtain the traditional Chinese medicine. The traditional Chinese medicine provided by the invention is applicable to the symptoms after the gynecological and obstetric surgery, and the traditional Chinese medicine is short in treatment course, rapid to take effects, free from toxic and side effects, wide in raw material sources and low in cost; drug mechanism can directly reach a focus, so as to obviously shorten the healing time of a wound after the surgery, inhibit bacteria, resist inflammation and alleviate pain and to avoid infection; the traditional Chinese medicine is effective on tonifying qi and promoting the generation of blood, clearing heat and alleviating pain, and controlling vomiting; and the traditional Chinese medicine is capable of effectively recovering the related symptoms after the gynecological and obstetric surgery and relieving pain of patients.

Description

A kind of Chinese medicine for recovering obstetrics and gynecology operation disease and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine for recovering obstetrics and gynecology operation disease and its preparation side Method.
Background technology
Abdominal is the conventional operation of department of obstetrics and gynecology, there are wound infection and healing problems.The lighter's subcutaneous fat liquefies And wound shallow-layer infection suppurates, severe one abdominal wound all splits, and uterine cavity infection and uterine incision split and cause massive hemorrhage, peritoneum Inflammation, septicemia etc., more severe patient jeopardizes patient vitals, and it is long to cause patient's hospital stayss, has increased financial burden, have impact on trouble The quality of life of person.Furthermore, easily occur losing blood with postoperative, vigour is impaired, vessels of the whole body being deficient in art, therefore many deficiency syndrome.In addition abdomen Swollen is also one of gynecologic surgery common sympton, can affect respiratory movement and veins of lower extremity backflow, and then induce pulmonary complication Formed with Lower Limb Thrombosis, make misery to patient, extend the hospital stayss.Therefore, timely and effectively prevention and treatment infection of incisional wound, mistake A series of post gynecologic operation disease such as blood body void and abdominal distention has important clinical meaning.
In tradition is controlled, usually oral drugs, intramuscular injection, application antibiotic or Chinese herbal medicine, oral drugs are to gastrointestinal Irritant, acupoint injection therapy patient is painful big, and patient is not often easily accepted by；Conventional antibiotic, side effect is larger, for body constitution Weak women is difficult to bear；The use of super other antibiotic only can increase side effects of pharmaceutical drugs and treatment cost, increases antibacterial Drug resistance, can not improve the time of wound healing, or even the confidence treated further can be defeated.Furthermore, women body itself Body void is weak, and long-term has no intention their physical recovery using antibiotic；And the fried complexity of Chinese herbal medicine, taste is not good, and curative effect is slow And unstable, after often having operation in patients, the several years is still in poor health, immunity degradation, easy secondary other diseases, and effect is undesirable.
Therefore it is badly in need of a kind of taking convenience, short treating period, instant effect, the medicinal application that has no toxic side effect in post gynecologic operation, It is easy to patient to recover and treat.
Content of the invention
It is an object of the invention to provide a kind of Chinese medicine for recovering obstetrics and gynecology operation disease and preparation method thereof, to solve The problem certainly proposing in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme：
A kind of Chinese medicine for recovering obstetrics and gynecology operation disease, is prepared from by the raw material of following weight portion：Herba Saussureae Involueratae 8～ 10 parts, 20～30 parts of Stigma Croci, 18～24 parts of morning glory, 10～12 parts of Radix Salviae Miltiorrhizae, 4～6 parts of Radix Angelicae Sinensis, 6～8 parts of Radix Wahlenbergiae Marginatae, Prunus persica f. compressa 12～16 parts of grass, 10～14 parts of Fructus Aurantii, 12～16 parts of Radix Notoginseng, 18～24 parts of Folium Artemisiae Argyi, 3～5 parts of Cortex Phellodendri, 5～7 parts of the Radix Rehmanniae, delicate fragrance 7～9 parts of osmanthus, 10～14 parts of globe-flower, 5～9 parts of the Radix Angelicae Dahuricae, 11～15 parts of Caulis et folium pavettae hongkongensis, 9～11 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), 6～10 parts of Rhizoma Corydalis, sugarcane 20～30 parts of sugar.
As the further scheme of the present invention：It is prepared from by the raw material of following weight portion：9 parts of Herba Saussureae Involueratae, Stigma Croci 25 Part, 21 parts of morning glory, 11 parts of Radix Salviae Miltiorrhizae, 5 parts of Radix Angelicae Sinensis, 7 parts of Radix Wahlenbergiae Marginatae, 14 parts of purslane speedwell Herba, 12 parts of Fructus Aurantii, 14 parts of Radix Notoginseng, Folium Artemisiae Argyi 21 Part, 4 parts of Cortex Phellodendri, 6 parts of the Radix Rehmanniae, 8 parts of Sarcococca ruscifolia Stapf, 12 parts of globe-flower, 7 parts of the Radix Angelicae Dahuricae, 13 parts of Caulis et folium pavettae hongkongensis, 10 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), 8 parts of Rhizoma Corydalis, 25 parts of sucrose.
A kind of preparation method of the described Chinese medicine for recovering obstetrics and gynecology operation disease, step is as follows：
(1) above-mentioned each raw material Chinese medicine is weighed by proportioning, clean and dry, mixing, it is ground into coarse fodder, cross 50～80 mesh sieves；
(2) add mixture in water, add the weight of water to be 6～8 times of crude drug gross weight, heated and boiled 50～ 60min, the volume fraction being subsequently adding 5～7 times of crude drug gross weight is 65% ethanol solution, reflux, extract, twice, every time Return time is 1～2h, and then united extraction liquid filter, filtrate recycling ethanol, and is concentrated into relative density when 50～54 DEG C Clear paste for 1.10～1.12；
(3) add sucrose mix homogeneously in above-mentioned body of paste, make final tcm product.
As the further scheme of the present invention：Described final tcm product is tablet, capsule, oral liquid, powder, pill Or syrup.
Compared with prior art, the invention has the beneficial effects as follows：
1st, Chinese medicine of the present invention is used for post gynecologic operation symptom, short treating period, instant effect, has no toxic side effect, raw material sources extensively, Low cost.
2nd, the Chinese medicine of the present invention is according to etiology and pathogenesis, and drug action mechanism can go directly focus, significantly shorten postoperative wound more The conjunction time, antibacterial anti-inflammatory ease pain, it is to avoid infection, reduce cicatrix rate, can QI invigorating and blood producing, tonifying speen and tonifying kidney, toxin expelling, clearing away heat to alleviate pain, Preventing or arresting vomiting, effectively recovers the associated conditions after obstetrics and gynecology operation, mitigates the misery of patient.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, Obviously, described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.Based in the present invention Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of not making creative work, all Belong to the scope of protection of the invention.
Embodiment 1
For recovering the Chinese medicine of obstetrics and gynecology operation disease, it is prepared from by the raw material of following weight portion：8 parts of Herba Saussureae Involueratae, hides 30 parts of Flos Carthami, 18 parts of morning glory, 12 parts of Radix Salviae Miltiorrhizae, 4 parts of Radix Angelicae Sinensis, 8 parts of Radix Wahlenbergiae Marginatae, 12 parts of purslane speedwell Herba, 14 parts of Fructus Aurantii, 12 parts of Radix Notoginseng, 24 parts of Folium Artemisiae Argyi, 3 parts of Cortex Phellodendri, 7 parts of the Radix Rehmanniae, 7 parts of Sarcococca ruscifolia Stapf, 14 parts of globe-flower, 5 parts of the Radix Angelicae Dahuricae, 15 parts of Caulis et folium pavettae hongkongensis, 9 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Rhizoma Corydalis 10 parts, 20 parts of sucrose.
The preparation process of the Chinese medicine of above-described embodiment is as follows：
(1) above-mentioned each raw material Chinese medicine is weighed by proportioning, clean and dry, mixing, it is ground into coarse fodder, cross 50 mesh sieves；
(2) add mixture in water, the weight of addition water is 6 times of crude drug gross weight, heated and boiled 50min, so The volume fraction of 5 times of crude drug gross weight of addition is 65% ethanol solution afterwards, and twice, each return time is reflux, extract, 1h, united extraction liquid then filter, filtrate recycling ethanol, and be concentrated into when 50 DEG C relative density be 1.10～1.12 clear Cream；
(3) sucrose and adjuvant are added in above-mentioned body of paste, and mix homogeneously, make capsule.
Embodiment 2
For recovering the Chinese medicine of obstetrics and gynecology operation disease, it is prepared from by the raw material of following weight portion：9 parts of Herba Saussureae Involueratae, hides 25 parts of Flos Carthami, 21 parts of morning glory, 11 parts of Radix Salviae Miltiorrhizae, 5 parts of Radix Angelicae Sinensis, 7 parts of Radix Wahlenbergiae Marginatae, 14 parts of purslane speedwell Herba, 12 parts of Fructus Aurantii, 14 parts of Radix Notoginseng, 21 parts of Folium Artemisiae Argyi, 4 parts of Cortex Phellodendri, 6 parts of the Radix Rehmanniae, 8 parts of Sarcococca ruscifolia Stapf, 12 parts of globe-flower, 7 parts of the Radix Angelicae Dahuricae, 13 parts of Caulis et folium pavettae hongkongensis, 10 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), unit 8 parts recklessly, 25 parts of sucrose.
The preparation process of the Chinese medicine of above-described embodiment is as follows：
(1) above-mentioned each raw material Chinese medicine is weighed by proportioning, clean and dry, mixing, it is ground into coarse fodder, cross 65 mesh sieves；
(2) add mixture in water, the weight of addition water is 7 times of crude drug gross weight, heated and boiled 55min, so The volume fraction of 6 times of crude drug gross weight of addition is 65% ethanol solution afterwards, and twice, each return time is reflux, extract, 1.5h, united extraction liquid then filter, filtrate recycling ethanol, and be concentrated into when 52 DEG C relative density be 1.10～1.12 clear Cream；
(3) add sucrose mix homogeneously in above-mentioned body of paste, make oral liquid.
Embodiment 3
For recovering the Chinese medicine of obstetrics and gynecology operation disease, it is prepared from by the raw material of following weight portion：10 parts of Herba Saussureae Involueratae, hides 20 parts of Flos Carthami, 24 parts of morning glory, 10 parts of Radix Salviae Miltiorrhizae, 6 parts of Radix Angelicae Sinensis, 6 parts of Radix Wahlenbergiae Marginatae, 16 parts of purslane speedwell Herba, 10 parts of Fructus Aurantii, 16 parts of Radix Notoginseng, 18 parts of Folium Artemisiae Argyi, 5 parts of Cortex Phellodendri, 5 parts of the Radix Rehmanniae, 9 parts of Sarcococca ruscifolia Stapf, 10 parts of globe-flower, 9 parts of the Radix Angelicae Dahuricae, 11 parts of Caulis et folium pavettae hongkongensis, 11 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), unit 6 parts recklessly, 30 parts of sucrose.
The preparation process of the Chinese medicine of above-described embodiment is as follows：
(1) above-mentioned each raw material Chinese medicine is weighed by proportioning, clean and dry, mixing, it is ground into coarse fodder, cross 80 mesh sieves；
(2) add mixture in water, the weight of addition water is 8 times of crude drug gross weight, heated and boiled 60min, so The volume fraction of 7 times of crude drug gross weight of addition is 65% ethanol solution afterwards, and twice, each return time is reflux, extract, 2h, united extraction liquid then filter, filtrate recycling ethanol, and be concentrated into when 54 DEG C relative density be 1.10～1.12 clear Cream；
(3) add sucrose mix homogeneously in above-mentioned body of paste, make syrup.
1st, safety research
The Chinese medicine of the present invention shows through safety toxicology test：LD50 is 11500mg/kg, Toxicological evaluation For nontoxic level, have no toxic side effect.
2nd, acute toxicity test
Above-mentioned laboratory sample is made suspension, be equivalent to the dosage of 350 times of clinical daily dosage to mouse stomach to Medicine, during observing, does not find that animal has any toxic reaction.Administration is observed for 20 days, none animal dead；At animal after death Dissect, its internal organs observes Non Apparent Abnormality.Experiment shows, gastric infusion does not measure the median lethal dose(LD 50) of the present invention, animal experiment Dosis tolerata be 300 times of clinical adult maximum dose daily.
3rd, long-term toxicity test for animals
Above-mentioned sample is supplied rat long term administration in 6 months for 15 times, 35 times, 70 times with clinical daily dosage, two dosage groups are big General activity after raticide, the mental status, hair, feces etc. are showed no obvious abnormalities；Peripheral hemogram before and after administration, including red thin Born of the same parents, platelet, hemoglobin, packed cell volume fluctuate all within normal range；Liver and kidney function index is showed no bright Development rings；In animal serum during off-test, the content of total protein, albumin, alkali phosphatase is no substantially poor compared with matched group Different；Electrocardioscopy is all no abnormal；Each main organs macroscopy has no the pathomorphisms such as obvious enlargement, hyperemia, necrosis Learn change；The weight coefficient of the organs such as the heart, liver, spleen, lung, kidney, thymus, adrenal gland no significant difference compared with matched group；Pathology Histological examination is showed no exception.These results suggest that the present invention is safer, no substantially poison is secondary in the range of institute's amount of reagent makees With.
4th, Pharmacodynamics experiment：
In the present invention, medicine opponent art knife abdominal part scratches the impact of mouse model
(1) scalpel abdominal part scratches the foundation of mouse model
Take healthy Kunming mouse 60, body weight 18-22g.Mouse web portion is scratched using scalpel after all mouse anesthesias Region 1cm × 1cm, depth lcm, fully expose wound surface, at random mice is divided into 3 groups, every group 20.
(2) packet administration and index determining
All groups are administered according to following dosage regimens：
Model control group：Outer painting normal saline；
Enoxacin group：Outer painting Enoxacin in Enoxacin Capsules；
Chinese medicine group of the present invention.
According to the dosage of 1g preparation/only, every 12h administration, observed result after 7 days, result be related to wound healing situation, Whole blood contrast viscosity, packed cell volume, erythrocyte sedimentation rate, clotting time, escherichia coli amount, euglobulin lysis time (ELT), fibrinolytic are lived Property, gonadal hormone estradiol (E2), follicle stimulating hormone (FSH).Discovery, every Comparative result matched group and enoxacin group after observation All have clear improvement and improve, improve rate about between 30-32%, the effect of heavy dose for the treatment of group is substantially.
5th, clinical practice
Case 1：Yuan, female, 42 years old, hysteromyoma was performed the operation, and abdominal distention, patient has Nausea and vomiting, that is, give after 48h The Chinese medicinal tablet two panels of the present invention, after 3h, patient feels enterokinesia, and after 5h, patient's abdominal distention, nausea mitigate, and abdominal distention is complete within second day Disappear.After continuous medication 3 days, They hurt pain disappears, and wound surface no infects, and heals after 5 days, has epidermis to produce, wound surface is repaiied substantially Multiple or whole reparations, and have rosy cheeks, somatosensory is good.
Case 2：Zhao, female, 50 years old, places panhysterectomy, abdominal distention stomachache occurs after 72h, toss about and feel uneasy, do not think to drink Food.Auscultation borborygmus are weak, that is, give the Chinese medicinal tablet two panels of the present invention, and after 3h, patient's sensation abdominal distention pain has mitigation, auscultation intestinal Ring sound strengthens, then medication two panels again after 6h, and patient's abdominal distention stomachache substantially mitigates, auscultation borborygmus loudness of a sound.After continuous medication 2 days, abdomen Swollen stomachache totally disappeared, and diet is normal；After 3 days, They hurt pain disappears, and wound surface no infects, and heals after 7 days, has epidermis to produce, wound surface Basic reparation or whole reparation, and have rosy cheeks, somatosensory is good.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie In the case of the spirit or essential attributes of the present invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power Profit requires rather than described above limits, it is intended that all in the implication and scope of the equivalency of claim by falling Change is included in the present invention.

Claims (4)

1. a kind of Chinese medicine for recovering obstetrics and gynecology operation disease is it is characterised in that be prepared from by the raw material of following weight portion： 8～10 parts of Herba Saussureae Involueratae, 20～30 parts of Stigma Croci, 18～24 parts of morning glory, 10～12 parts of Radix Salviae Miltiorrhizae, 4～6 parts of Radix Angelicae Sinensis, Radix Wahlenbergiae Marginatae 6～ 8 parts, 12～16 parts of purslane speedwell Herba, 10～14 parts of Fructus Aurantii, 12～16 parts of Radix Notoginseng, 18～24 parts of Folium Artemisiae Argyi, 3～5 parts of Cortex Phellodendri, the Radix Rehmanniae 5～7 Part, 7～9 parts of Sarcococca ruscifolia Stapf, 10～14 parts of globe-flower, 5～9 parts of the Radix Angelicae Dahuricae, 11～15 parts of Caulis et folium pavettae hongkongensis, 9～11 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Rhizoma Corydalis 6～ 10 parts, 20～30 parts of sucrose.
2. the Chinese medicine for recovering obstetrics and gynecology operation disease according to claim 1 is it is characterised in that by following weight portion Raw material be prepared from：9 parts of Herba Saussureae Involueratae, 25 parts of Stigma Croci, 21 parts of morning glory, 11 parts of Radix Salviae Miltiorrhizae, 5 parts of Radix Angelicae Sinensis, 7 parts of Radix Wahlenbergiae Marginatae, celestial 14 parts of Fructus Persicae grass, 12 parts of Fructus Aurantii, 14 parts of Radix Notoginseng, 21 parts of Folium Artemisiae Argyi, 4 parts of Cortex Phellodendri, 6 parts of the Radix Rehmanniae, 8 parts of Sarcococca ruscifolia Stapf, 12 parts of globe-flower, the Radix Angelicae Dahuricae 7 parts, 13 parts of Caulis et folium pavettae hongkongensis, 10 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), 8 parts of Rhizoma Corydalis, 25 parts of sucrose.
3. a kind of preparation method of the Chinese medicine for recovering obstetrics and gynecology operation disease as claimed in claim 1 or 2, its feature exists In step is as follows：
(1) above-mentioned each raw material Chinese medicine is weighed by proportioning, clean and dry, mixing, it is ground into coarse fodder, cross 50～80 mesh sieves；
(2) add mixture in water, the weight of addition water is 6～8 times of crude drug gross weight, heated and boiled 50～60min, The volume fraction being subsequently adding 5～7 times of crude drug gross weight is 65% ethanol solution, reflux, extract, twice, every time flow back when Between be 1～2h, united extraction liquid then filter, filtrate recycling ethanol, and be concentrated into when 50～54 DEG C relative density be 1.10 ～1.12 clear paste；
(3) add sucrose mix homogeneously in above-mentioned body of paste, make final tcm product.
4. the preparation method of the Chinese medicine for recovering obstetrics and gynecology operation disease according to claim 3 is it is characterised in that institute Stating final tcm product is tablet, capsule, oral liquid, powder, pill or syrup.
CN201610791950.XA 2016-08-31 2016-08-31 Traditional Chinese medicine for recovering symptoms of gynecological and obstetric surgery and preparation method of traditional Chinese medicine Pending CN106389702A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108671073A (en) * 2018-07-13 2018-10-19 贾方平 A kind of Chinese medicine and preparation method thereof for post gynecologic operation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103721075A (en) * 2014-01-26 2014-04-16 张丽娟 Traditional Chinese medicine for use after gynecologic surgery and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103721075A (en) * 2014-01-26 2014-04-16 张丽娟 Traditional Chinese medicine for use after gynecologic surgery and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108671073A (en) * 2018-07-13 2018-10-19 贾方平 A kind of Chinese medicine and preparation method thereof for post gynecologic operation

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