CN106389636A - Preparation method of traditional Chinese medicine capable of treating chronic diarrhea - Google Patents
Preparation method of traditional Chinese medicine capable of treating chronic diarrhea Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention discloses a preparation method of a traditional Chinese medicine capable of treating chronic diarrhea. The preparation method comprises the following steps:8-12 parts of prepared common monkshood daughter roots, 5-10 parts of Chinese magnoliavine fruits, 6-11 parts of cherokee rose fruits, 6-9 parts of semen plantaginis, 9-15 parts of atractylodes rhizomes, 4-8 parts of poria cocos, 9-15 parts of pilose asiabell roots, 6-10 parts of common aucklandia roots, 9-15 parts of psoralea corylifolia and 5-8 parts of cablin patchouli herbs are weighed in parts by weight; all the traditional Chinese medicinal materials are immersed in clear water or purified water; the immersed traditional Chinese medicinal materials and a medicinal liquid with the materials immersed are added to a decoction container and decocted together after the decoction container is covered. The preparation method has the beneficial effects that the traditional Chinese medicine is taken orally directly on the basis of the understanding and treatment principles of the chronic diarrhea symptom mechanism, performs elimination and reinforcement simultaneously, and has effects of tonifying qi, eliminating dampness and regulating the spleen and the stomach; the curative effect is remarkable, the quality is easy to control, the stability is good, and adverse reactions are avoided basically.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically, it is a kind of Chinese medicinal preparation method that can treat chronic diarrhea.
Background technology
Diarrhoea refers to that defecation frequency increases, and feces are thin, or even gushes as watery object plane speech.Clinically common dry intestinal disease
Disease.
At present, when people suffer from chronic diarrhea disease, in the city that medical condition is more flourishing, people are to control to hospital
Treat, typically all treated using Western medicine or have an injection, and in small towns, more particularly away from small towns, outlying village,
When people suffer from the disease of chronic diarrhea, because family income is low, living in penury, locality lacks medical condition if it is desired to control
Disease needs to spend the city that a lot of travelling expenses go medical condition more flourishing to go to seek medical advice, the medical expense of hospital and medical expenses in addition
Costliness, people often do not go sick treatment, give free rein to fully recover, some patients therefore delay therapic opportunity.
Content of the invention
Evident in efficacy, instant effect, good stability can treat chronic diarrhea it is an object of the invention to provide a kind of
Chinese medicinal preparation method.
The present invention is achieved through the following technical solutions：A kind of Chinese medicinal preparation method that can treat chronic diarrhea, including with
Under several steps：
Step S1：In parts by weight, weigh 8 ~ 12 parts of Radix Aconiti Lateralis Preparata, 5 ~ 10 parts of Fructus Schisandrae Chinensis, 6 ~ 11 parts of Fructus Rosae Laevigatae, 6 ~ 9 parts of Semen Plantaginiss,
9 ~ 15 parts of Rhizoma Atractylodis, 4 ~ 8 parts of Poria, 9 ~ 15 parts of Radix Codonopsis, 6 ~ 10 parts of the Radix Aucklandiae, 9 ~ 15 parts of Fructus Psoraleae, 5 ~ 8 parts of Herba Pogostemonis；
Step S2：By above-mentioned whole raw material of Chinese medicine medicines, clear water or pure water is used in advance to soak 30 minutes, water consumption for immersion is 0.9 ~
1.1L；
Step S3：The liquid medicine of the raw material of Chinese medicine medicine after soaking and its immersion is added in decocting container, adds a cover and jointly decoct；
Step S4：So that decocting container herb liquid is seethed with excitement with high heat, reuse slow fire and boil 15 ~ 20 minutes, 2 when boiling medicine, need to be stirred
~ 3 times；
Step S5：After the completion of decoction, plus proper amount of clear water or pure water did not had medicine, carried out second decoction, decocted duration and degree of heating method
Ibid, decocting time 15 ~ 20 minutes；
Step S6：Leach medicinal liquid, obtained medicinal liquid is endo-medicine.
Described step S3 includes following step：
Step S301：First Radix Aconiti Lateralis Preparata, Fructus Rosae Laevigatae, Semen Plantaginiss, Radix Codonopsis are added in decocting container and are decocted 10 minutes with small fire；
Step S302：Again Rhizoma Atractylodis, Poria, the Radix Aucklandiae, Fructus Psoraleae are added in decocting container and are decocted 10 minutes with small fire；
Step S303：Again Fructus Schisandrae Chinensis, Herba Pogostemonis are added in decocting container.
The decocting that decoction includes adding for the first time 10 times amount for three times boils 2 hours, and the decocting that second adds 8 times amount boils 1 hour, the
The decocting that three times add 6 times amount boils 1 hour.
Described decocting container is marmite, enamel ware or rustless steel, avoids and uses ironware.
Described Fructus Schisandrae Chinensis are Fructus Schisandrae Chinensis (processed with vinegar).
A kind of crude drug pharmacology of Chinese medicine composition treating chronic diarrhea of the present invention：
Radix Aconiti Lateralis Preparata：The pungent, sweet in the mouth of property, poisonous, return, the heart, kidney spleen channel.Recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, by wind-cold damp pathogen.For YANG-depletion
Collapse, cold weak pulse of limb, sexual impotence, cold womb, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, arthralgia due to cold-dampnes.
Fructus Schisandrae Chinensis：Warm in nature, sour in the mouth, sweet.Return lung warp, heart channel, kidney channel.The astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid of convergence, kidney calming.Belong to and receiving
Lung-intestine astringent medicinal under puckery medicine classification
Fructus Rosae Laevigatae：Mild-natured, sour in the mouth, sweet, puckery.Return kidney channel, bladder warp, large intestine channel.Controlling nocturnal emission with astringent drugs, reducing urination, astringing intestine to stop diarrhea, antidiarrheal.Belong to astringent medicinal
The astringent sperm contracting urine leukorrhagia stopping medicine of lower classification.
Semen Plantaginiss：Cold nature, sweet in the mouth.Return kidney channel, Liver Channel, lung meridian, small intestine meridian.Clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, dispel
Expectorant.Belong to the stranguria-relieving diuretic of classification under damp-clearing drug.
Rhizoma Atractylodis：Warm in nature, acrid in the mouth, hardship.Returns spleen warp, stomach, Liver Channel.Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.Belong to damp-resolving medicinal.
Poria：Mild-natured, sweet in the mouth, light.Thoughts of returning home warp, lung meridian, spleen channel, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Belong to promoting diuresis to eliminate damp pathogen
The edema-alleviating diuretic of medicine subordinate classification.
Radix Codonopsis：Mild-natured, sweet in the mouth.Returns spleen warp, lung meridian.Invigorating the spleen and replenishing QI, strengthening spleen and tonifying lung.Belong to the QI invigorating of qi-restoratives medicine subordinate classification
Medicine.
The Radix Aucklandiae：Warm in nature, acrid in the mouth, hardship.Returns spleen warp, stomach, large intestine channel, tri-jiao channel, gallbladder meridian.Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Belong to
QI regulating medicine.
Fructus Psoraleae：Warm in nature, acrid in the mouth, hardship.Return kidney channel, spleen channel.Warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.Belong to qi-restoratives medicine subordinate classification
Yang-tonifying drug.
Herba Pogostemonis：Slightly warm in nature, acrid in the mouth.Return stomach, spleen channel, lung meridian.Eliminating turbid pathogen with aromatics, the preventing or arresting vomiting that whets the appetite, deliver expelling summer-heat.Belong to removing dampness
Medicine.
The present invention compared with prior art, has advantages below and beneficial effect：
The present invention be based on to the understanding of chronic diarrhea symptom mechanism and Therapeutic Principle, the method using being directly administered orally, attack benefit and
Apply, there is the effect of QI invigorating removing dampness, function of spleen and stomach regulating, evident in efficacy, quality is easily controlled, good stability has no adverse reaction substantially.
Specific embodiment
With reference to embodiment, the present invention is described in further detail, but embodiments of the present invention not limited to this.
Embodiment 1：
A kind of Chinese medicine formula that can treat chronic diarrhea, including 8 ~ 12 parts of Radix Aconiti Lateralis Preparata in parts by weight, 5 ~ 10 parts of Fructus Schisandrae Chinensis,
6 ~ 11 parts of Fructus Rosae Laevigatae, 6 ~ 9 parts of Semen Plantaginiss, 9 ~ 15 parts of Rhizoma Atractylodis, 4 ~ 8 parts of Poria, 9 ~ 15 parts of Radix Codonopsis, 6 ~ 10 parts of the Radix Aucklandiae, Fructus Psoraleae 9 ~
15 parts, 5 ~ 8 parts of Herba Pogostemonis.
The method of the present embodiment medicine preparation, including following step：
Step S1：By above-mentioned whole raw material of Chinese medicine medicines, clear water or pure water is used in advance to soak 30 minutes, water consumption for immersion is 0.9 ~
1.1L；
Step S2：The liquid medicine of the raw material of Chinese medicine medicine after soaking and its immersion is added in decocting container, adds a cover and jointly decoct；
Step S3：So that decocting container herb liquid is seethed with excitement with high heat, reuse slow fire and boil 15 ~ 20 minutes, 2 when boiling medicine, need to be stirred
~ 3 times；
Step S4：After the completion of decoction, plus proper amount of clear water or pure water did not had medicine, carried out second decoction, decocted duration and degree of heating method
Ibid, decocting time 15 ~ 20 minutes；
Step S5：Leach medicinal liquid, obtained medicinal liquid is endo-medicine.
Embodiment 2：
In the present embodiment, described 8 parts of Radix Aconiti Lateralis Preparata, 5 parts of Fructus Schisandrae Chinensis, 6 parts of Fructus Rosae Laevigatae, 6 parts of Semen Plantaginiss, 9 parts of Rhizoma Atractylodis, 4 parts of Poria,
9 parts of Radix Codonopsis, 6 parts of the Radix Aucklandiae, 9 parts of Fructus Psoraleae, 5 parts of Herba Pogostemonis.
Embodiment 3：
In the present embodiment, described 10 parts of Radix Aconiti Lateralis Preparata, 7 parts of Fructus Schisandrae Chinensis, 7 parts of Fructus Rosae Laevigatae, 8 parts of Semen Plantaginiss, 12 parts of Rhizoma Atractylodis, Poria 6
Part, 12 parts of Radix Codonopsis, 8 parts of the Radix Aucklandiae, 10 parts of Fructus Psoraleae, 6 parts of Herba Pogostemonis.
Embodiment 4：
In the present embodiment, described 12 parts of Radix Aconiti Lateralis Preparata, 10 parts of Fructus Schisandrae Chinensis, 11 parts of Fructus Rosae Laevigatae, 9 parts of Semen Plantaginiss, 15 parts of Rhizoma Atractylodis, Poria
8 parts, 15 parts of Radix Codonopsis, 10 parts of the Radix Aucklandiae, 15 parts of Fructus Psoraleae, 8 parts of Herba Pogostemonis.
Toxicology test：
Acute toxicity test：
Experimental observation, because measuring LD50, therefore has carried out the mensure of maximum dosage-feeding.Chinese medicine compound prepared by embodiment 1
Mixture is dissolved in sterile saline, is configured to solution gavage mice, and result shows, raw with medicine maximum administration concentration 9.65
Medicine/ml, maximum administered volume 50ml/kg was administered twice to mouse stomach in 24 hours, and mice maximum dosage-feeding is 763.25g
Crude drug/kg, untoward reaction and death in animal, anatomic observation each internal organs no abnormality seen.
Long term toxicity test：
SD rat 80 is applied in this test, and Chinese medicine compound mixture prepared by embodiment 1 is dissolved in sterile saline, configuration
Become solution gavage, if matched group and 24g, 35g, 49g crude drug/kg dosage group, continuous gavage is administered 12 weeks, observes in the present invention
The impact to animal indices for the drug composition.Result of the test shows, successive administration 12 weeks, and the Chinese medicine composition of the present invention is to big
The body weight of Mus, food ration, peripheral hemogram, clotting time, electrocardiogram, organ index etc. all have no significant effect；Blood biochemical 12
Item index determining result, 12 weeks low dose group BiLi values of administration are higher than matched group（P<0.05)；Low dose group, middle dose group TP value
Higher than matched group（P<0.05), but all within normal physiologic range, other indexs compare no significant difference with matched group.Recover
Phase each administration group indices measured value compares equal no significant difference with matched group.Each group each internal organs gross examination of skeletal muscle no abnormality seen.
It is directed to the clinical statisticses data of various Chronic Diarrhea Patients using medicine of the present invention：
Through the Clinical practice of 200 patients, wherein male patient 127, female patient 73, medication age object 20 ~ 60 years old.Wherein
Minimum 21 years old, maximum 59 years old, 38 years old mean age；Slight chronic diarrhea disease 42, moderate chronic diarrheal disease 72, severe chronic
Diarrheal disease 36.
1st, Wang, man, native, 37 years old, native.In the case of no obvious inducement, diarrhoea, feed occurred before half a year
Obvious afterwards, diarrhoea number of times for up to 6 times, with borborygmus, no stomachache, abdominal distention, no Nausea and vomiting, no heating, fear of cold in weak, abdomen,
In half a year, body weight substantially mitigates 3kg.Take chronic diarrhea symptom after 3 courses for the treatment of orally using the prescription of the embodiment of the present invention 1 to disappear,
Energy makes moderate progress.
The above, be only presently preferred embodiments of the present invention, and not the present invention is done with any pro forma restriction, every according to
Any simple modification above example made according to the technical spirit of the present invention, equivalent variations, each fall within the protection of the present invention
Within the scope of.
Claims (5)
1. a kind of Chinese medicinal preparation method that can treat chronic diarrhea it is characterised in that：Including following step：
Step S1：In parts by weight, weigh 8 ~ 12 parts of Radix Aconiti Lateralis Preparata, 5 ~ 10 parts of Fructus Schisandrae Chinensis, 6 ~ 11 parts of Fructus Rosae Laevigatae, 6 ~ 9 parts of Semen Plantaginiss,
9 ~ 15 parts of Rhizoma Atractylodis, 4 ~ 8 parts of Poria, 9 ~ 15 parts of Radix Codonopsis, 6 ~ 10 parts of the Radix Aucklandiae, 9 ~ 15 parts of Fructus Psoraleae, 5 ~ 8 parts of Herba Pogostemonis；
Step S2：By above-mentioned whole raw material of Chinese medicine medicines, clear water or pure water is used in advance to soak 30 minutes, water consumption for immersion is 0.9 ~
1.1L；
Step S3：The liquid medicine of the raw material of Chinese medicine medicine after soaking and its immersion is added in decocting container, adds a cover and jointly decoct；
Step S4：So that decocting container herb liquid is seethed with excitement with high heat, reuse slow fire and boil 15 ~ 20 minutes, 2 when boiling medicine, need to be stirred
~ 3 times；
Step S5：After the completion of decoction, plus proper amount of clear water or pure water did not had medicine, carried out second decoction, decocted duration and degree of heating method
Ibid, decocting time 15 ~ 20 minutes；
Step S6：Leach medicinal liquid, obtained medicinal liquid is endo-medicine.
2. a kind of Chinese medicinal preparation method that can treat chronic diarrhea according to claim 1 it is characterised in that：Described
Step S3 includes following step：
Step S301：First Radix Aconiti Lateralis Preparata, Fructus Rosae Laevigatae, Semen Plantaginiss, Radix Codonopsis are added in decocting container and are decocted 10 minutes with small fire；
Step S302：Again Rhizoma Atractylodis, Poria, the Radix Aucklandiae, Fructus Psoraleae are added in decocting container and are decocted 10 minutes with small fire；
Step S303：Again Fructus Schisandrae Chinensis, Herba Pogostemonis are added in decocting container.
3. a kind of Chinese medicinal preparation method that can treat chronic diarrhea according to claim 1 it is characterised in that：Decoct three
The decocting of secondary inclusion first time plus 10 times amount boils 2 hours, and the decocting that second adds 8 times amount boils 1 hour, adds 6 times amount for the third time
Decocting boils 1 hour.
4. a kind of Chinese medicinal preparation method that can treat chronic diarrhea according to claim 3 it is characterised in that：Described
Decocting container is marmite, enamel ware or rustless steel, avoids and uses ironware.
5. a kind of Chinese medicinal preparation method that can treat chronic diarrhea according to claim 1 it is characterised in that：Described
Fructus Schisandrae Chinensis are Fructus Schisandrae Chinensis (processed with vinegar).
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2016
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|---|---|---|---|---|
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