CN106383464A - System for automatic pumping of liquid based on ARM single-chip microcomputer, control method, and application - Google Patents
System for automatic pumping of liquid based on ARM single-chip microcomputer, control method, and application Download PDFInfo
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- CN106383464A CN106383464A CN201610828010.3A CN201610828010A CN106383464A CN 106383464 A CN106383464 A CN 106383464A CN 201610828010 A CN201610828010 A CN 201610828010A CN 106383464 A CN106383464 A CN 106383464A
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- master controller
- position switch
- host computer
- motor
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/04—Programme control other than numerical control, i.e. in sequence controllers or logic controllers
- G05B19/042—Programme control other than numerical control, i.e. in sequence controllers or logic controllers using digital processors
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Abstract
The invention relates to a system for the automatic pumping of liquid based on an ARM single-chip microcomputer, a control method, and an application. The system comprises an upper computer, a main controller, an execution module, and a communication module. The main controller is connected with the upper computer and the execution module through the communication module. The main controller carries out the data exchange with the upper computer through the communication module, receives an instruction of the upper computer, and transmits the data of the execution module to the upper computer. The main controller carries out the data exchange with the execution module through the communication, carries out the parameter setting of the execution module through the received instruction of the upper computer, and controls the execution module to operate. The main controller reads the current position and operation state of the execution module, i.e., the data of the execution module. The system achieves the automatic pumping and pouring of liquid, guarantees that there is always liquid in an injector, and achieves the continuous and stable preparation of a microballoon. All operation parameters can be monitored and set through a computer. There is no need of human intervention in the whole process, and the system can carry out the recording of operation parameters in the operation process.
Description
Technical field
The present invention relates to a kind of system, control method and application automatically extracted based on ARM chip microcontroller liquid, especially
It is related to the application in the continuous preparation system of full-automatic microsphere, belong to Microfluidic droplet technical field.
Background technology
With respect to traditional material, microsphere has the advantages that little, big, good fluidity of specific surface area of granule etc. is unique, in addition,
Microsphere has low toxicity, efficient, slow release, long-acting characteristic in terms of drug release, has important meaning to improving utilization ratio of drug,
Become the ideal carrier of somatomedin, antibiotic, cancer therapy drug at present, received much concern.
Microfluidic droplet technology generally refers to each lead into two kinds of immiscible fluids as dispersion phase and continuous phase micro-
Fluidic chip, is accurately manipulated to the fluid entering microchannel, thus realizing the generation of drop, function, the liquid such as transporting, merge
Drip and can form microsphere by in-situ solidifying after generating.
Microfluidic droplet technology is the new method preparing microsphere that developed recently gets up, than conventional microsphere preparation side
Method, the Microsphere Size prepared using Microfluidic droplet technology is homogeneous, size tunable, sphericity are high.But existing using micro-fluidic liquid
The device that the technology of dripping prepares microsphere is to be connected with micro-fluidic chip using the syringe of different size, is driven by pushing syringe
Dynamic fluid enters micro-fluidic chip, as shown in figure 1, realizing generation and the in-situ solidifying of drop.The shortcoming of existing apparatus is microsphere
Yield is subject to syringe capacity impact very big, and the sample in syringe exhausts i.e. microsphere preparation and stops it is necessary to manually into syringe
Add sample and could continue to prepare microsphere it is impossible to the work of long-term continuous-stable is produced it is impossible to realize continuous automatic batch metaplasia, system
Whole human intervention is needed during standby.
Content of the invention
For the deficiencies in the prior art, the invention provides a kind of based on what ARM chip microcontroller liquid extracted automatically be
System；
Present invention also offers the method for work of said system and the application in the continuous preparation system of full-automatic microsphere.
The present invention realizes by main controller controls syringe and switching valve that sample automatically extracts and perfusion is it is ensured that syringe
In have liquid all the time, realize the preparation of microsphere continuous-stable, whole without human intervention.All of operational factor can be passed through upper
Machine is monitored and is given, and the operational factor in running can be recorded.
The technical scheme is that：
A kind of system automatically being extracted based on ARM chip microcontroller liquid, including host computer, master controller, performing module
And communication module, described master controller connects described host computer and described performing module respectively by described communication module；
Described master controller carries out data exchange by described communication module and described host computer, receives the finger of host computer
Order, and the data of described performing module is uploaded to described host computer；
Described master controller carries out data exchange by described communication module and described performing module, upper by receive
The instruction of machine, carries out parameter setting to described performing module, controls described performing module to run；Read described performing module current
Position, running status, i.e. the data of described performing module.
According to currently preferred, described master controller is stm32f407 series A RM single-chip microcomputer, described master controller bag
Include RCC clock module, the integrated 5 USART serial ports of described master controller；
Described performing module includes syringe, motor, switching valve, upper limit position switch, lower position switch, the described upper limit
Bit switch, described lower position switch are separately positioned on the top of described syringe, lower section, and described switching valve is arranged on described injection
The top of device, described motor is arranged on described syringe rear, for driving described syringe upstream or downstream, described step
The drive part of stepper motor is TB6560 motor special integrated circuit；
Described communication module includes RS485 serial ports, RS232 serial ports；
Described master controller carries out data friendship with described host computer by way of described RS232 serial ports is with MODBUS slave station
Change, described master controller is polled to described performing module, and the instruction of the change parameter that the host computer receiving is sent
It is sent to AVR 8 single-chip microcomputer MEGA16 of series, the poll that AVR 8 single-chip microcomputer MEGA16 of series send to described master controller refers to
Order is responded, and receives the parameter setting that described master controller sends, and realizes to the on off control of described motor, to described
The control of the switch of switching valve, the detection to described upper limit position switch and described lower position switch, up to described syringe
Speed and the control of downstream rate；
Described master controller read by way of described RS485 serial ports is with main website poll described motor start and stop,
The operation shape of the surplus of sample, the switch of described switching valve, described upper limit position switch, described lower position switch in described syringe
State, and the data of reading is sent to described host computer；
Described master controller passes through reserved powered memory in the RCC clock module that no write number of times limits and realizes to institute
State the real time record of sample surplus in syringe.To realize the function that after power down, current run location is not lost.
Master controller is stm32f407 series A RM single-chip microcomputer, and described master controller internal clock frequencies are up to 168MHz,
The integrated 5 USART serial ports of master controller, can easily and host computer and syringe realize number respectively by serial port drive chip
According to exchange.
According to currently preferred, model stm32f407 of described master controller.
According to currently preferred, described upper limit position switch and described lower position switch are correlation photoswitch.
When not, when spacing up and down, correlation photoswitch turns on and exports high level, when reaching spacing, correlation light
Electric switch is blocked output low level.
The control method of said system, concrete steps include：
(1) instruction is sent to described master controller by RS232 interface described in MODBUS agreement by described host computer；
(2) instruction that the host computer receiving transmits is sent to AVR 8 single-chip microcomputers of series by described master controller
The instruction that MEGA16, AVR 8 single-chip microcomputer MEGA16 of series send to described master controller responds, and receives described main control
The parameter setting that device sends, realize the on off control to described motor, the control of the switch to described switching valve, to described
Upper limit position switch and the detection of described lower position switch, the speed uplink to described syringe and the control of downstream rate；
(3) described master controller reads described motor, described by way of described RS485 serial ports is with main website poll
Syringe, the running status of described switching valve, described upper limit position switch and described lower position switch, including described motor
The surplus of sample, the switch of described switching valve, described upper limit position switch and described lower position switch in start and stop, described syringe
Detection, and the data being read is sent to described host computer by RS232 interface described in MODBUS agreement；
(4) when upper limit is detected, switching valve described in described main controller controls is opened, according to the lower scanning frequency setting
Degree extracts sample automatically, and when lower limit is detected, motor described in described main controller controls stops, and controls described switching
Valve cuts out, and the speed uplink according to setting is irrigated.
According to currently preferred, in described step (2), realize the on off control to described motor, specifically include：
The instruction that described AVR 8 single-chip microcomputer MEGA16 of series give according to described master controller, sends frequency by its internal PWM module
The pulse that rate is variable, dutycycle is constant gives described TB6560 motor special integrated circuit to control rotating speed, controls institute by I/O mouth
State motor traffic direction.
After system start-up, switching valve is closed, and the up perfusion of 4 motors, if be not detected by the upper limit during up
Position then keeps perfusion state, if upper limit is detected during up, corresponding switching valve is opened, the descending extraction of motor,
If being not detected by lower limit in extraction process, continuing to extract, if lower limit is detected, corresponding to switching valve and closing, time delay one
Fix time, the up perfusion of 4 motors, circulates this process, realizes automatically continuous microsphere preparation.
The application of said system, for the continuous preparation system of full-automatic microsphere.
Beneficial effects of the present invention are：
The present invention controls syringe and switching valve to realize the automatic extraction of liquid and perfusion it is ensured that beginning in syringe by CPU
There is liquid eventually, realize the preparation of microsphere continuous-stable.All of operational factor can be monitored by computer and be given.Whole nothing
Need human intervention, and the operational factor in running can be recorded.
Brief description
Fig. 1 is the device preparing microsphere in prior art using microflow control technique；
Fig. 2 is the structural representation of performing module of the present invention；
Fig. 3 is the structured flowchart of the system automatically being extracted based on ARM chip microcontroller liquid；
Fig. 4 is master controller, RS485 serial ports and performing module circuit connection diagram；
Fig. 5 is master controller, RS 232 serial ports and host computer circuit connection diagram；
Fig. 6 is the method for work schematic flow sheet of the system automatically being extracted based on ARM chip microcontroller liquid；
1st, host computer, 2, master controller, 3, performing module, 4, communication module, 5, syringe, 6, motor, 7, switching
Valve, 8, upper limit position switch, 9, lower position switch, 10, RS485 serial ports, 11, RS232 serial ports, 12, the special control of TB6560 motor
Chip, 13, RCC clock module.
Specific embodiment
With reference to Figure of description and embodiment, the present invention is further qualified, but not limited to this.
Embodiment 1
A kind of system automatically being extracted based on ARM chip microcontroller liquid, including host computer 1, master controller 2, execution mould
Block 3 and communication module 4, master controller 2 connects host computer 1 and performing module 4 respectively by communication module 3；
Model stm32f407 of master controller 2, master controller 2 includes RCC clock module 13, master controller 2 integrated 5
Individual USART serial ports；5 USART serial ports include UART1 serial ports, UART2 serial ports, UART3 serial ports, UART4 serial ports, UART5 string
Mouthful；As shown in Figure 3.
Performing module 3 includes syringe 5,4 motors 6, switching valve 7, upper limit position switch 8, lower position switch 9, on
Limit switch 8, lower position switch 9 are separately positioned on the top of syringe 5, lower section, and switching valve 7 is arranged on the top of syringe 5,
Motor 6 is arranged on syringe 5 rear, and for driving syringe 5 upstream or downstream, the drive part of motor 6 is
TB6560 motor special integrated circuit 12；As shown in Figure 2.
Communication module 4 includes RS485 serial ports 10, RS232 serial ports 11；
Master controller 2, RS485 serial ports 10 and performing module 3 circuit connection diagram are as shown in Figure 4；Wherein, RS485 serial ports 10
One end is passed through UE2 chip in master controller 2 and is connected with UART5 serial ports, and RS485 serial ports 10 other end connects performing module 3；
Master controller 2, RS232 serial ports 11 and host computer 1 circuit connection diagram are as shown in Figure 5；Wherein, RS232 serial ports 11 1
End is connected with UART1 serial ports in master controller 2 and UART2 serial ports, executes reception and the transmission of data, and RS232 serial ports 11 is another
End connects host computer 1 by com port, and the com port of host computer 1 is J1, J2 shown in Fig. 5；
Master controller 2 carries out data exchange, master control with host computer 1 by way of RS232 serial ports 11 is with MODBUS slave station
Device 2 processed is polled to performing module 3, and the instruction of the change parameter that the host computer receiving 1 is sent is sent to AVR series
The poll instruction that 8 single-chip microcomputer MEGA16, AVR 8 single-chip microcomputer MEGA16 of series send to master controller 2 responds, and receives
The parameter setting that master controller 2 sends, realize the on off control to motor 6, the control of the switch to switching valve 7, to upper
Limit switch 8 and the detection of lower position switch 9, the speed uplink to syringe 5 and the control of downstream rate；
Master controller 2 reads the start and stop of motor 6, in syringe 5 by way of RS485 serial ports 10 is with main website poll
The surplus of sample, the switch of switching valve 7, upper limit position switch 8, the running status of lower position switch 9, and the data reading is transmitted
To host computer 1；
Master controller 2 passes through reserved powered memory in the RCC clock module 13 that no write number of times limits and realizes to note
The real time record of the surplus of sample in emitter 5.To realize the function that after power down, current run location is not lost.
Master controller 2 is stm32f407 series A RM single-chip microcomputer, and master controller 2 internal clock frequencies are up to 168MHz, main
The integrated 5 USART serial ports of controller 2, can easily be realized with host computer 1 and syringe 5 respectively by serial port drive chip
Data exchange.
Upper limit position switch 8 and lower position switch 9 are correlation photoswitch.
When not, when spacing up and down, correlation photoswitch turns on and exports high level, when reaching spacing, correlation light
Electric switch is blocked output low level.
Embodiment 2
A kind of control method of the system automatically being extracted based on ARM chip microcontroller liquid described in embodiment 1, concrete step
Rapid inclusion：
(1) instruction is sent to master controller 2 by MODBUS agreement RS232 interface 11 by host computer 1；
(2) instruction that the host computer receiving 1 transmits is sent to AVR 8 single-chip microcomputer MEGA16 of series by master controller 2,
The instruction that AVR 8 single-chip microcomputer MEGA16 of series send to master controller 2 responds, and the parameter that reception master controller 2 sends sets
Fixed, realize the on off control to motor 6, the control of the switch to switching valve 7, to upper limit position switch 8 and lower position switch 9
Detection, the speed uplink to syringe 5 and the control of downstream rate；
(3) master controller 2 reads motor 6, syringe 5, switching by way of RS485 serial ports 10 is with main website poll
The running status of valve 7, upper limit position switch 8 and lower position switch 9, including in the start and stop of motor 6, syringe 5 sample remaining
Amount, the detection of the switch of switching valve 7, upper limit position switch 8 and lower position switch 9, and the data being read is assisted by MODBUS
View RS232 interface 11 sends host computer 1 to；
(4) when upper limit is detected, master controller 2 controls switching valve 7 to open, automatic according to the downstream rate setting
Extract sample, when lower limit is detected, master controller 2 controls motor 6 to stop, and controls switching valve 7 to close, according to setting
Good speed uplink is irrigated.
In step (2), realize the on off control to motor 6, specifically include：AVR 8 single-chip microcomputer MEGA16 roots of series
The instruction giving according to master controller 2, by its internal pulse that PWM module transmission frequency is variable, dutycycle is constant to TB6560
Motor special integrated circuit 12, to control rotating speed, controls motor 6 traffic direction by I/O mouth.
After system start-up, switching valve 7 is closed, and the up perfusion of 4 motors 6, if be not detected by during up
Spacing then holding perfusion state, if upper limit is detected during up, corresponding switching valve 7 is opened, and motor 6 is descending to be taken out
Taking, if being not detected by lower limit in extraction process, continuing to extract, if lower limit is detected, corresponding switching valve 7 is closed, and prolongs
When certain time, the up perfusion of 4 motors 6, circulate this process, realize automatically continuous microsphere preparation.As shown in Figure 6.
Embodiment 3
A kind of systematic difference automatically being extracted based on ARM chip microcontroller liquid described in embodiment 1, for automatically micro-
Ball is continuously prepared.
Claims (7)
1. a kind of system automatically being extracted based on ARM chip microcontroller liquid it is characterised in that include host computer, master controller,
Performing module and communication module, described master controller connects described host computer and described execution mould respectively by described communication module
Block；
Described master controller carries out data exchange by described communication module and described host computer, receives the instruction of host computer, and
The data of described performing module is uploaded to described host computer；
Described master controller carries out data exchange by described communication module and described performing module, by the host computer of reception
Instruction, carries out parameter setting to described performing module, controls described performing module to run；Read described performing module present bit
Put, running status, i.e. the data of described performing module.
2. a kind of system automatically being extracted based on ARM chip microcontroller liquid according to claim 1 it is characterised in that
Described master controller is stm32f407 series A RM single-chip microcomputer, and described master controller includes RCC clock module, described master controller
Integrated 5 USART serial ports；
Described performing module includes syringe, motor, switching valve, upper limit position switch, lower position switch, and described upper limit is opened
Close, described lower position switch is separately positioned on the top of described syringe, lower section, described switching valve is arranged on described syringe
Top, described motor is arranged on described syringe rear, for driving described syringe upstream or downstream, described stepping electricity
The drive part of machine is TB6560 motor special integrated circuit；
Described communication module includes RS485 serial ports, RS232 serial ports；
Described master controller carries out data exchange with described host computer by way of described RS232 serial ports is with MODBUS slave station,
Described master controller is polled to described performing module, and the instruction of the change parameter that the host computer receiving is sent sends
To AVR 8 single-chip microcomputer MEGA16 of series, the poll that AVR 8 single-chip microcomputer MEGA16 of series send to described master controller instruct into
Row response, receives the parameter setting that described master controller sends, and realizes to the on off control of described motor, to described switching
The control of the switch of valve, the detection to described upper limit position switch and described lower position switch, the speed uplink to described syringe
And the control of downstream rate；
Described master controller reads start and stop of described motor, described by way of described RS485 serial ports is with main website poll
The surplus of sample, the switch of described switching valve, described upper limit position switch, the running status of described lower position switch in syringe,
And the data of reading is sent to described host computer；
Described master controller passes through reserved powered memory in the RCC clock module that no write number of times limits and realizes to described note
The real time record of the surplus of sample in emitter.
3. a kind of system automatically being extracted based on ARM chip microcontroller liquid according to claim 1 and 2, its feature exists
In model stm32f407 of described master controller.
4. a kind of system automatically being extracted based on ARM chip microcontroller liquid according to claim 2 it is characterised in that
Described upper limit position switch and described lower position switch are correlation photoswitch.
5. the control method of a kind of system automatically being extracted based on ARM chip microcontroller liquid described in claim 2, its feature
It is, concrete steps include：
(1) instruction is sent to described master controller by RS232 interface described in MODBUS agreement by described host computer；
(2) instruction that the host computer receiving transmits is sent to AVR series 8 single-chip microcomputer MEGA16, AVR by described master controller
The instruction that 8 single-chip microcomputer MEGA16 of series send to described master controller responds, and receives the ginseng that described master controller sends
Number set, realize the on off control to described motor, the control of the switch to described switching valve, to described upper limit position switch
And detection, the speed uplink to described syringe and the control of downstream rate of described lower position switch；
(3) described master controller reads described motor, described injection by way of described RS485 serial ports is with main website poll
Device, the running status of described switching valve, described upper limit position switch and described lower position switch, including opening of described motor
Stop, the surplus of sample, the inspection of the switch of described switching valve, described upper limit position switch and described lower position switch in described syringe
Survey, and the data being read is sent to described host computer by RS232 interface described in MODBUS agreement；
(4) when upper limit is detected, switching valve described in described main controller controls is opened, according to the downstream rate setting certainly
Dynamic extraction sample, when lower limit is detected, motor described in described main controller controls stops, and controls described switching valve to close
Close, the speed uplink according to setting is irrigated.
6. the method for work of a kind of system automatically being extracted based on ARM chip microcontroller liquid according to claim 5, its
It is characterised by, in described step (2), realize the on off control to described motor, specifically include：Described AVR 8 lists of series
The instruction that piece machine MEGA16 gives according to described master controller, by its internal PWM module transmission frequency is variable, dutycycle is constant
Pulse give described TB6560 motor special integrated circuit to control rotating speed, by I/O mouth control described motor operation side
To.
7. a kind of systematic difference automatically being extracted based on ARM chip microcontroller liquid described in claim 2, for full-automatic
Microsphere is continuously prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610828010.3A CN106383464A (en) | 2016-09-18 | 2016-09-18 | System for automatic pumping of liquid based on ARM single-chip microcomputer, control method, and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610828010.3A CN106383464A (en) | 2016-09-18 | 2016-09-18 | System for automatic pumping of liquid based on ARM single-chip microcomputer, control method, and application |
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| CN106383464A true CN106383464A (en) | 2017-02-08 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610828010.3A Pending CN106383464A (en) | 2016-09-18 | 2016-09-18 | System for automatic pumping of liquid based on ARM single-chip microcomputer, control method, and application |
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Cited By (1)
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| CN107491007A (en) * | 2017-08-25 | 2017-12-19 | 广州中国科学院沈阳自动化研究所分所 | A kind of miniature constant current solution feed system in laboratory and control method |
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