CN106380620A - Preparation method of chitosan/ionic liquid composite membrane - Google Patents
Preparation method of chitosan/ionic liquid composite membrane Download PDFInfo
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- CN106380620A CN106380620A CN201610837458.1A CN201610837458A CN106380620A CN 106380620 A CN106380620 A CN 106380620A CN 201610837458 A CN201610837458 A CN 201610837458A CN 106380620 A CN106380620 A CN 106380620A
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- ionic liquid
- composite membrane
- shitosan
- liquid composite
- chitosan
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/28—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/16—Nitrogen-containing compounds
- C08K5/34—Heterocyclic compounds having nitrogen in the ring
- C08K5/3442—Heterocyclic compounds having nitrogen in the ring having two nitrogen atoms in the ring
- C08K5/3445—Five-membered rings
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2201/00—Foams characterised by the foaming process
- C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
- C08J2201/048—Elimination of a frozen liquid phase
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2201/00—Properties
- C08L2201/06—Biodegradable
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/16—Applications used for films
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- Polymers & Plastics (AREA)
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Abstract
The invention discloses a preparation method of a chitosan/ionic liquid composite membrane. The preparation method comprises the following steps: firstly adding chitosan in an acetic acid solution, and stirring at room temperature; then dropwise adding an ionic liquid solution in a prepared chitosan solution, and stirring at room temperature; finally carrying out dialysis treatment and freeze drying on an obtained colloid, thus obtaining the chitosan/ionic liquid composite membrane. The chitosan/ionic liquid composite membrane prepared by the invention has better mechanical performance and better heavy metal ion and anionic dye adsorption performance, has the advantages of good biocompatibility, controllable degradation performance and the like, is a biodegradable composite material having great development potential, and can be widely applied to the fields of food, medicine science and the like.
Description
Technical field
The invention belongs to biological medical polymer material technical field is and in particular to a kind of shitosan/ionic liquid is combined
The preparation method of film.
Background technology
Shitosan, also known as chitosan, is to be obtained through deacetylation by the chitin that nature is widely present
's.Shitosan has following characteristic：Biocompatibility preferably, and can be biodegradable, and catabolite is nontoxic.Shitosan these
Premium properties by all trades and professions extensive concern, in the application study of the numerous areas such as medicine, food, biochemistry and biomedical engineering
Achieve major progress.
Ionic liquid itself, as a kind of environmental protection catalyst and reaction dissolvent, has non-volatile, good conduction
The advantages of property, wider electrochemical window and selective dissolution ability, it is constantly subjected to the attention of Chinese scholars.Meanwhile, ion
The architectural feature of liquid itself, can give other materials some unique performances.Ionic liquid closes in organic catalysis at present
It is used widely in the fields such as one-tenth, electrochemistry formated, biochemistry.
Content of the invention
It is an object of the invention to provide a kind of preparation method of shitosan/ionic liquid composite membrane, its preparation condition letter
Just, process is simple；Gained composite membrane has the advantages that good mechanical property, good biocompatibility, degradation property are controlled, is a kind of tool
The biodegradable composite of the potentiality that grow a lot, can be used as food fresh keeping, biological antibiotic and anti-biotic material, extensively uses
In fields such as food, medical science, agricultural, commodity.
For achieving the above object, the present invention adopts the following technical scheme that：
A kind of preparation method of shitosan/ionic liquid composite membrane, it comprises the following steps：
（1）1.5-2.0 g shitosan is added in the acetic acid solution that 50mL volumetric concentration is 1%, room temperature magnetic agitation 4-10
h；
（2）The ionic liquid solution that 120mL concentration is 10-20 mg/mL is added drop-wise to step（1）In gained chitosan solution, room
Warm magnetic agitation 2-10 h；
（3）By step（2）The colloid obtaining freeze-drying after dialysis treatment, obtains final product described shitosan/ionic liquid composite membrane.
Step（2）In ionic liquid used be imidazoles villaumite, can be 1- carboxymethyl -3- methylimidazole villaumite.
Prepared shitosan/ionic liquid composite membrane is used as food fresh keeping material or anti-biotic material.
The beneficial effects of the present invention is：
（1）Evaporate film casting method compared to solution, preparation method of the present invention can make solvent thoroughly discharge, make product purer；And adopt
Carry out process to be also beneficial to film surface and be internally formed loose structure with freeze-drying, this not only can strengthen the mechanical performance of film,
Also good gas permeability and degradation property can be made it have, thus can be used as food fresh keeping material or anti-biotic material.
（2）Preparation condition of the present invention is easy, process is simple it is easy to operation, equipment cheap it is easy to promote.
（3）The present invention raw materials used shitosan abundance, has good biocompatibility.
（4）Shitosan prepared by the present invention/ionic liquid composite membrane has excellent stability, good mechanical performance
And biocompatibility.
（5）Shitosan prepared by the present invention/ionic liquid composite membrane be a kind of tool grow a lot potentiality can be biological
The composite of degraded, it has the advantages that good biocompatibility, degradation property are controlled, can be used as food fresh keeping, biological antibiotic
And anti-biotic material, it is widely used in the fields such as food, medical science, agricultural, commodity.
Brief description
Fig. 1 is the SEM figure of shitosan/ionic liquid composite membrane prepared by embodiment 1.
Fig. 2 is shitosan/ionic liquid composite membrane prepared by embodiment 1 to anionic dye（Sodium indigotindisulfonate）Suction
Attached ability measurement result.
Fig. 3 is the anti-microbial property test result of shitosan/ionic liquid composite membrane prepared by embodiment 2-4.
Specific embodiment
In order that content of the present invention easily facilitates understanding, with reference to specific embodiment to of the present invention
Technical scheme is described further, but the present invention is not limited only to this.
Embodiment 1
（1）1.5g shitosan is added in the acetic acid solution that 50mL volumetric concentration is 1%, room temperature magnetic agitation 4 h；
（2）1- carboxymethyl -3- methylimidazole villaumite the ionic liquid solution that 120mL concentration is 10 mg/mL is added drop-wise to step
（1）In gained chitosan solution, room temperature magnetic agitation 2 h；
（3）By step（2）The colloid obtaining freeze-drying after dialysis treatment, obtains final product shitosan/ionic liquid composite membrane.
Embodiment 2
（1）1.6 g shitosans are added in the acetic acid solution that 50mL volumetric concentration is 1%, room temperature magnetic agitation 6 h；
（2）1- carboxymethyl -3- methylimidazole villaumite the ionic liquid solution that 120mL concentration is 12 mg/mL is added drop-wise to step
（1）In gained chitosan solution, room temperature magnetic agitation 4 h；
（3）By step（2）The colloid obtaining freeze-drying after dialysis treatment, obtains final product shitosan/ionic liquid composite membrane.
Embodiment 3
（1）1.8 g shitosans are added in the acetic acid solution that 50mL volumetric concentration is 1%, room temperature magnetic agitation 8 h；
（2）1- butyl -3- methylimidazole villaumite the ionic liquid solution that 120mL concentration is 16 mg/mL is added drop-wise to step（1）
In gained chitosan solution, room temperature magnetic agitation 8 h；
（3）By step（2）The colloid obtaining freeze-drying after dialysis treatment, obtains final product shitosan/ionic liquid composite membrane.
Embodiment 4
（1）2.0 g shitosans are added in the acetic acid solution that 50mL volumetric concentration is 1%, room temperature magnetic agitation 10 h；
（2）1- pi-allyl -3- methylimidazole villaumite the ionic liquid solution that 120mL concentration is 20 mg/mL is added drop-wise to step
（1）In gained chitosan solution, room temperature magnetic agitation 10 h；
（3）By step（2）The colloid obtaining freeze-drying after dialysis treatment, obtains final product shitosan/ionic liquid composite membrane.
1. the shitosan prepared by pair embodiment 1-4/thickness of ionic liquid composite membrane, mechanical strength, elongation at break
It is measured, the results are shown in Table 1.
Table 1
2. shitosan/ionic liquid composite membrane the field emission scanning electron microscope prepared by embodiment 1（FESEM）Carry out pattern table
Levy, its result is shown in Fig. 1.As shown in figure 1, film surface is in honeycomb structure, this not only contributes to the enhancing of film mechanical strength, also favorably
In the gas permeability improving film, film can be made to have good fresh-keeping effect, also can give its degradation property so as to can be by micro- in nature
The biological catabolism with animal and plant body.
3. shitosan/ionic liquid composite membrane prepared by embodiment 1 is immersed certain density indigo disulfonic acid sodium solution
In, stirring at normal temperature 180min, and separated in time sampling, with dye strength in ultraviolet specrophotometer measurement solution, measure
Its absorption property to sodium indigotindisulfonate, result is shown in Fig. 2.As seen from Figure 2, with the prolongation of process time, in solution
The content of sodium indigotindisulfonate substantially reduce it was demonstrated that shitosan of the present invention/ionic liquid composite membrane anionic dye is had good
Good adsorption effect.
4. choose Escherichia coli（E. coli, ATCC090401）As model, embodiment 2- is characterized using inhibition zone method
Shitosan prepared by 4/ionic liquid composite membrane suppresses the performance of germ contamination, and result is shown in Fig. 3.As seen from Figure 3, diaphragm week
Enclose that inhibition zone is fairly obvious, show that shitosan of the present invention/ionic liquid composite membrane has good fungistatic effect, be used as
Anti-biotic material.
The foregoing is only presently preferred embodiments of the present invention, all impartial changes done according to scope of the present invention patent with
Modify, all should belong to the covering scope of the present invention.
Claims (6)
1. a kind of shitosan/ionic liquid composite membrane preparation method it is characterised in that：Comprise the following steps：
（1）Add chitosan in the acetic acid solution that volumetric concentration is 1%, room temperature magnetic agitation；
（2）Ionic liquid solution is added drop-wise to step（1）In gained chitosan solution, room temperature magnetic agitation；
（3）By step（2）The colloid obtaining freeze-drying after dialysis treatment, obtains final product described shitosan/ionic liquid composite membrane.
2. according to claim 1 shitosan/ionic liquid composite membrane preparation method it is characterised in that：Step（1）In
The consumption of shitosan is 1.5-2.0 g, and the consumption of acetic acid solution is 50mL.
3. according to claim 1 shitosan/ionic liquid composite membrane preparation method it is characterised in that：Step（1）Magnetic force
The time of stirring is 4-10 h.
4. according to claim 1 shitosan/ionic liquid composite membrane preparation method it is characterised in that：Step（2）Institute
The concentration stating ionic liquid solution is 10-20 mg/mL, and addition is 120mL；
Ionic liquid used is imidazoles villaumite.
5. according to claim 1 shitosan/ionic liquid composite membrane preparation method it is characterised in that：Step（2）In
The time of room temperature magnetic agitation is 2-10 h.
6. a kind of shitosan/ionic liquid composite membrane of method as claimed in claim 1 preparation it is characterised in that：For conduct
Food fresh keeping material or anti-biotic material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610837458.1A CN106380620A (en) | 2016-09-21 | 2016-09-21 | Preparation method of chitosan/ionic liquid composite membrane |
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|---|---|---|---|
| CN201610837458.1A CN106380620A (en) | 2016-09-21 | 2016-09-21 | Preparation method of chitosan/ionic liquid composite membrane |
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| CN201610837458.1A Pending CN106380620A (en) | 2016-09-21 | 2016-09-21 | Preparation method of chitosan/ionic liquid composite membrane |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106824113A (en) * | 2017-03-07 | 2017-06-13 | 辽宁大学 | A kind of preparation and its application of glyoxaline ion liquid modification of chitosan adsorbent |
| CN108148212A (en) * | 2018-01-23 | 2018-06-12 | 青岛科技大学 | A kind of preparation method of chitosan bacteriostatic film and products thereof |
| CN112058103A (en) * | 2020-08-21 | 2020-12-11 | 齐齐哈尔大学 | Cellulose grafted carboxymethyl imidazole chloride salt gas separation membrane and preparation method thereof |
| CN115368600A (en) * | 2022-08-08 | 2022-11-22 | 贵州大学 | Preparation method and application of chitosan proton type ionic liquid water-soluble film |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101503530A (en) * | 2009-01-16 | 2009-08-12 | 西北师范大学 | Chitosan / ion liquid conductive compound film and preparation thereof |
| CN102168323A (en) * | 2011-02-24 | 2011-08-31 | 天津工业大学 | Method for preparing chitosan and chitin functional materials by taking ionic liquid as solvent |
| CN103409849A (en) * | 2013-07-15 | 2013-11-27 | 东华大学 | Method for preparing chitosan hollow fiber membrane through treating composite ionic liquid as solvent |
| CN104927070A (en) * | 2015-03-12 | 2015-09-23 | 青岛科技大学 | Preparation method of chitosan membrane |
-
2016
- 2016-09-21 CN CN201610837458.1A patent/CN106380620A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101503530A (en) * | 2009-01-16 | 2009-08-12 | 西北师范大学 | Chitosan / ion liquid conductive compound film and preparation thereof |
| CN102168323A (en) * | 2011-02-24 | 2011-08-31 | 天津工业大学 | Method for preparing chitosan and chitin functional materials by taking ionic liquid as solvent |
| CN103409849A (en) * | 2013-07-15 | 2013-11-27 | 东华大学 | Method for preparing chitosan hollow fiber membrane through treating composite ionic liquid as solvent |
| CN104927070A (en) * | 2015-03-12 | 2015-09-23 | 青岛科技大学 | Preparation method of chitosan membrane |
Non-Patent Citations (2)
| Title |
|---|
| YUBING XIONG ET AL.: "Preparation and characterization of conductive chitosan–ionic liquid composite membranes", 《POLYM ADVANCED TECHNOLOGIES》 * |
| 蔡立芳,何领好,宋锐: "离子液体/壳聚糖复合膜的制备及性能研究", 《郑州轻工业学院学报(自然科学版)》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106824113A (en) * | 2017-03-07 | 2017-06-13 | 辽宁大学 | A kind of preparation and its application of glyoxaline ion liquid modification of chitosan adsorbent |
| CN106824113B (en) * | 2017-03-07 | 2020-03-03 | 辽宁大学 | Preparation and application of imidazole ionic liquid modified chitosan adsorbent |
| CN108148212A (en) * | 2018-01-23 | 2018-06-12 | 青岛科技大学 | A kind of preparation method of chitosan bacteriostatic film and products thereof |
| CN108148212B (en) * | 2018-01-23 | 2020-11-27 | 青岛科技大学 | Preparation method of chitosan antibacterial film and product thereof |
| CN112058103A (en) * | 2020-08-21 | 2020-12-11 | 齐齐哈尔大学 | Cellulose grafted carboxymethyl imidazole chloride salt gas separation membrane and preparation method thereof |
| CN112058103B (en) * | 2020-08-21 | 2022-06-21 | 齐齐哈尔大学 | Cellulose grafted carboxymethyl imidazole chloride salt gas separation membrane and preparation method thereof |
| CN115368600A (en) * | 2022-08-08 | 2022-11-22 | 贵州大学 | Preparation method and application of chitosan proton type ionic liquid water-soluble film |
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