CN106376930A - 一种治疗慢性腹泻的营养药膳粉及其制备方法 - Google Patents
一种治疗慢性腹泻的营养药膳粉及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗慢性腹泻的营养药膳粉及其制备方法,该营养药膳粉由中药组分和食粉按质量比1:(1.5‑2)组成;所述中药组分由以下重量份的原料制成:黄芪15‑20份、党参8‑15份、炒白术10‑15份、干姜10‑15份、血藤5‑10份、五味子8‑15份、甘草8‑15份;所述食粉由以下重量份的原料制成:谷粉20‑30份;山楂20‑25份、茯苓15‑20份、大枣10‑15份;动物肝粉15‑30份;复合水溶性维生素3‑6份。本发明的营养药膳粉中,各原料组方合理,配伍科学,特别适合慢性腹泻患者使用,疗效确切,安全无毒副作用。
Description
技术领域
本发明涉及一种治疗慢性腹泻的营养药膳粉及其制备方法。
背景技术
慢性腹泻是临床上的常见病,属于中医“久泻”,“泄泻”。相当于西医所说的慢性肠炎,非特异性结肠炎等。其病程长、症状反复发作,常因饮食不当,秋季加重,缠绵难愈的特点。久泻不愈,耗损气血,致使脾肾虚弱,即西医营养不良症,重者累及其他脏器,严重影响着病人的生活质量。
目前,对于慢性腹泻症,西药对症治疗,以抗生素控制感染为主,而抗生素药物存有一定的不良反应,不易长期应用,其治疗期间可有效的控制腹泻症,而停药后易复发。在中药治疗方面,中医应对慢性腹泻,以辩证施治的方法,在服药期间有一定的效果,而多数患者难以久服中药剂,同样存在停药后易复发的问题。本发明研制的“一种治疗慢性腹泻的营养药膳粉”,经资料检索查新,尚未见有“治养结合”类报道。
发明内容
本发明的目的是提供一种治疗慢性腹泻的营养药膳粉,该营养药膳粉是由中药组分和药膳粉组成,以“治养结合”作为其成方原则,旨在对慢性腹泻(脾肾虚型泄泻)进行营养食疗调理,以提高对其病症的治疗疗效,降低副作用,提高患者的生活质量。
本发明的另一目的是提供上述营养药膳粉的制备方法。
为实现上述目的,本发明采用下述技术方案:
一种治疗慢性腹泻的营养药膳粉,由中药组分和食粉按质量比1:(1.5-2)组成;
所述中药组分由以下重量份的原料制成:
黄芪15-20份、党参8-15份、炒白术10-15份、干姜10-15份、血藤5-10份、五味子8-15份、甘草8-15份;
所述食粉由以下重量份的原料制成:
谷粉20-30份;山楂20-25份、茯苓15-20份、大枣10-15份;动物肝粉15-30份;复合水溶性维生素3-6份;
所述谷粉选自小麦粉、黄豆粉、玉米粉、大米粉、小米粉、燕麦粉中的一种或多种。
所述山楂、茯苓和大枣均为药食两用品。
所述复合水溶性维生素由以下重量百分比的组分复配而成:
维生素B1 20-40%、维生素B215-30%、维生素B6 10-25%、维生素C 20-25%;
所述动物肝粉,由猪肝、或羊肝动物肝脏,经常规方法制备而成。
动物肝粉主要提供人体必需的维生素A、维生素E等脂溶性维生素。
本发明的营养食疗机理:
本发明的营养药膳粉是在中医药及药食同源理论的理论指导下,根据临床工作经验,结合营养学、食物成分表,辩证施治而研究设计了“治养结合”的方案。
针对脾肾虚的症状发明设计营养药膳粉组方,目的是针对性选以药物功效发挥健脾和益气、扶正的作用;以营养药膳,提高免疫的功能,增强健脾止泻功效。
本发明的治疗慢性腹泻的营养药膳粉并非是中药组分和食粉的简单叠加,而是在中医辨证施膳及营养学的理论指导下,将中药组分和食粉科学配伍,制成一种既有药物功效,又有食品营养功效的特殊功能食品。
本发明的中药材组分、配伍,遵照中医药学相须、相使、相畏、相杀、相恶、相反的配伍,及制备原则,同时,参照现代制备工艺,将中药材、食物等,分别以水煮方法、烘焙方法、粉碎方法等,以最大限度的提取出有效成分并保证有效成分的活性,从而保证产品的临床效果。
本发明通过将多味中药与食物进行配伍,已达到药借食性,食助药力相互协同发挥健脾补肾、和胃、化湿止泻的作用,充分发挥了治养结合的优势。
所选用的中药材原料,其药理分析如下:
黄芪:甘,微温。归肺、脾经。补气升阳,固表止汗,利水消肿,生津养血,行滞通痹,托毒排脓,敛疮生肌。用于气虚乏力,食少便溏,中气下陷,久泻脱肛,便血崩漏,表虚自汗,气虚水肿,内热消渴,血虚萎黄,半身不遂,痹痛麻木,痈疽难溃,久溃不敛。
党参:甘,平。归脾、肺经。健脾益肺,养血生津。用于脾肺气虚,食少倦怠,咳嗽虚喘,气血不足,面色萎黄,心悸气短,津伤口渴,内热消渴。
白术:苦、甘,温。归脾、胃经。健脾益气,燥湿利水,止汗,安胎。用于脾虚食少,腹胀泄泻,痰饮眩悸,水肿,自汗,胎动不安。
甘草:甘,平。归心、肺、脾、胃经。补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。
干姜:为姜科植物姜Zingiber oj-jicinale Rosc.的干燥根茎。温中散寒,回阳通脉,温肺化饮;用于脘腹冷痛,呕吐泄泻,肢冷脉微,寒饮喘咳。
五味子:为木兰科植物五味子Schisandra chinensis(Turcz.)Baill.的干燥成熟果实。习称“北五味子”。酸、甘,温。归肺、心、肾经。收敛固涩,益气生津,补肾宁心。用于久嗽虚喘,梦遗滑精,遗尿尿频,久泻不止,自汗盗汗,津伤口渴,内热消渴,心悸失眠。
血藤:为木兰科植物翼梗五味子或华中五味子的藤茎或根。养血消瘀,理气化湿。治痨伤吐血,肢节酸疼,心胃气痛,脚气痿痹,***,跌打损伤。
所选用的药膳粉的原料,其食疗性能分析如下:
山楂:是药材又是食品,酸、甘,微温。归脾、胃、肝经。消食健胃,行气散瘀,化浊降脂。用于肉食积滞,胃脘胀满,泻痢腹痛,瘀血经闭,产后瘀阻,心腹刺痛,胸痹心痛,疝气疼痛,高脂血症。焦山楂消食导滞作用增强。用于肉食积滞,泻痢不爽。
茯苓:是药材又属菌类食品,甘、淡,平。归心、肺、脾、肾经。利水渗湿,健脾,宁心。用于水肿尿少,痰饮眩悸,脾虚食少,便溏泄泻,心神不安,惊悸失眠。
大枣:是药材又是食品,甘,温。归脾、胃、心经。补中益气,养血安神。用于脾虚食少,乏力便溏,妇人脏躁。
谷粉:甘,平。补脾益气、血,安五脏。
动物肝脏:其性温,甘,归肝经。市售产品肝粉。营养成分富含有脂溶性维生素A。维持机体正常免疫功能,促进组织修复,抗氧化,防癌抗癌等功能。
复合维生素类属水溶性,是人体必需的营养元素,由以下重量百分比的组分复配而成:
维生素B1 30%、维生素B2 30%、维生素B6 20%、维生素C 20%。
维生素C:具有抗氧化,促进***形成,提高免疫功能,解毒防癌。
维生素B2:参与生物氧化与能量代谢,维持皮肤黏膜完整性,抗氧化等。
维生素B6:参与物质代谢,维持免疫与神经***功能等。
维生素B1:增加免疫细胞数量从而提高免疫功能。
对于本发明的药膳粉而言,由谷粉、复合维生素和动物肝粉等原料组成,具有增强健脾止泻,提高免疫的功能;其中,通过维生素剂的添加,能够保证人体生理需要量,弥补腹泻患者禁忌水果等寒性食物而导致的维生素等营养元素的亏乏,维生素能增强免疫、促进肠道功能修复起到及其重要的作用。
本发明的营养药膳粉中,药汁、药粉、食粉各原料组分是一个有机的整体,缺一不可。发明人在研发过程中发现,减少或替换上述营养药膳粉中的任何一种原料组分,则营养药膳粉整体的作用效果显著降低;在本发明的营养药膳粉组方的基础上再增加其他的原料组分,营养药膳粉的整体效果并未有明显的改善,甚至有营养药膳粉的整体效果降低的情况出现。
本发明还提供上述营养药膳粉的制备方法,步骤如下:
(1)中药汁的制备:
将黄芪、党参、炒白术、干姜、血藤、五味子和甘草混合,加水煎煮,滤过,合并滤液,浓缩至相对密度为1.1-1.2(50℃测);
(2)将谷粉、山楂、茯苓、大枣分别炒制,然后与中药汁、动物肝粉和复合水溶性维生素混合均匀,干燥,粉碎,即得营养药膳粉。
步骤(1)中,加水煎煮的方法为:加水煎煮两次,第一次加10倍重量的水,煎煮2小时;第二次加6倍重量的水,煎煮1.5小时。
步骤(2)中,所述谷粉的制备方法为:将谷物原料清洗后,加水浸泡30-45分钟,沥干,粉碎,然后进行糊化处理,糊化温度为70-80℃,时间为3-5分钟,干燥,粉碎,过80-100目筛,即得谷粉。通过对谷粉进行糊化处理,可以使原料中所含的淀粉充分糊化,并使产品中所含的蛋白质变性,更易消化吸收。
上述营养药膳粉在制备治疗慢性腹泻的药物制剂、或在制备改善慢性腹泻的保健品或特殊营养食品中的应用也是本发明保护的范围。
本发明还提供一种改善慢性腹泻的特殊医学用途功能食品,以上述营养药膳粉为有效成分。
本发明的有益效果:
(1)本发明的“营养药膳粉”,不同于单用药物治疗,又不同于单纯米粥调养,而是从整体出发,根据患者久泻体虚的症状,辩证选择健脾补肾,益气养血止泻的中药及药食两用之品,辅助谷物增强健脾功效,同时添加营养制剂纠正其久泻丢失及限食水果而致缺乏的维生素等,患者在食用营养药膳的同时不仅获取营养物质,而且摄取了具有治疗作用的药物,利于患者康复。
通过对本发明“营养药膳粉”的应用观察显示,综合调治比单一的中药或西药治疗优越,且无不良反应,患者乐意接受。因此,本发明的治养结合类营养药膳粉,具有临床进一步应用研究的意义和价值。
(2)本发明的营养药膳粉中,各原料组方合理,配伍科学,药物之间共同发挥了健脾补肾、温中和胃、化湿止泻的作用,具有明显的增效作用,充分发挥了相须相使的配伍关系。
(3)本发明的营养药膳粉特别适合慢性腹泻病人使用,营养药膳粉中的食物具有健脾养胃,固肠止泻之功能,能“益气止泻,补中益气,暖脾胃,止虚寒泄痢”。本发明食粉中的经炒烘干处理后,可以治疗腹泻,能够健脾补肾、增强其固肠止泻的功能;同时还可以降低肠道的抗淀粉性,益于肠道吸收。通过实际应用观察,收到了良好的效果。营养药膳粉的组合,药疗加食疗的协同作用,达到了治养结合的效果,慢性腹泻病人临床试验表明,本发明的营养药膳粉对慢性腹泻的治愈率高,而且复发率低。
具体实施方式
下面通过具体实例对本发明进行进一步的阐述,应该说明的是,下述实施例仅是为了解释本发明,并不对其内容进行限定。
实施例1:治疗慢性腹泻的营养药膳粉的制备
配方:由中药组分和食粉按重量比1:1.5组成。
其中,中药组分的原料组成为:
黄芪18份、党参12份、炒白术12份、干姜12份、血藤8份、五味子12份、甘草12份。
食粉的原料组成为:
谷粉25份;山楂22份、茯苓18份、大枣12份;动物肝粉25份;复合水溶性维生素4份。
谷粉为小麦粉,制备方法为:将小麦清洗后,加水浸泡30-45分钟,沥干,粉碎,然后进行糊化处理,糊化温度为70-80℃,时间为3-5分钟,干燥,粉碎,过80目筛,即得。
动物肝粉为猪肝粉,常规的市售产品。
复合水溶性维生素是由以下重量百分比的组分复配而成:
维生素B1 30%、维生素B2 30%、维生素B6 20%、维生素C 20%。
制备方法:
(1)将黄芪、党参、炒白术、干姜、血藤、五味子和甘草混合,加水煎煮两次,第一次加10倍重量的水,煎煮2小时;第二次加6倍重量的水,煎煮1.5小时,滤过,合并滤液,浓缩至相对密度为1.1-1.2(50℃测),制得中药汁;
(2)将谷粉、山楂、茯苓、大枣分别炒制,然后与中药汁、动物肝粉和复合水溶性维生素混合均匀,干燥,粉碎,即得营养药膳粉。
实施例2:治疗慢性腹泻的营养药膳粉的制备
配方:由中药组分和食粉按重量比1:2组成。
其中,中药组分的原料组成为:
黄芪15份、党参15份、炒白术10份、干姜15份、血藤5份、五味子15份、甘草8份。
食粉的原料组成为:
谷粉20份;山楂25份、茯苓15份、大枣15份;动物肝粉15份;复合水溶性维生素6份。
谷粉为小麦粉,制备方法同实施例1。
动物肝粉和复合维生素同实施例1。
制备方法同实施例1。
实施例3:改善慢性腹泻的特殊医学用途功能食品的制备
按实施例1或实施例2的方法制备成营养药膳粉,再加入甜味剂,经模压成型,制成快速、方便食品,便于外出携带食用。
对比例1:
本发明人在研发过程中对营养药膳粉的药物组分中具有相近药性的多味原料药进行了配伍关系的考察和药效的研究,结果发现,即使某几味原料药之间的药性相似,但与其他不同的原料药配伍使用后,其药效效果差别显著。例如:将实施例1配方中具有健脾益肺、补气升阳功效的黄芪和党参替换为具有相似功效的人参和当归,将白术替换为茯苓;按实施例1的制备方法制备。
以常规方法建立小鼠腹泻模型,考察本发明实施例1和对比例1的营养药膳粉对慢性腹泻的治疗效果,动物试验表明,本发明实施例1制备的营养药膳粉对于小鼠慢性腹泻模型的治疗效果要显著优于对比例1。说明本发明的营养药膳粉符合中药的配伍关系,各组分之间具有协同促进作用,并非是具有相似药性的原料药的简单替换和组合。
对比例2:
中药组合物中各原料药的药量是标识药力的,即使方剂的药物组成相同,但若药物的用量各不相同,其药力则有大小之分,配伍关系则有君臣佐使之变,从而其功主治则各有所异。本发明人在研发过程中对中药组合物中的各个原料的含量进行了考察和药效的研究,结果发现,不合适的原料配比关系,其药效效果差别显著。例如:将实施例1中黄芪的用量调整为10份,党参的用量调整为20份,血藤的用量调整为5份,其他原料的用量同实施例1,并按实施例1的方法制备。
以常规方法建立小鼠腹泻模型,考察本发明实施例1和对比例2的营养药膳粉对慢性腹泻的治疗效果,动物试验表明,本发明实施例1的营养药膳粉对于慢性腹泻小鼠动物模型的治疗效果要显著优于对比例2。说明本发明的营养药膳粉中各原料药的用量并非是常规的调整所能得到的,本发明的原料组方中,各原料药材的用量配比是根据其药材特性、君臣佐使配伍等各种考虑因素决定的,对于药物组方的整体药效起到非常重要的作用。
动物试验(止泻试验):
1.试验方法:
选用健康成年昆明小鼠50只,雌雄各半,体重20±2g。试验前将动物称重,编号,随机分成空白对照组、对照组、试验1组和试验2组。
建立番泻叶致小鼠腹泻模型,即每只小鼠每天采用4g/(kg.d)的剂量连续灌胃番泻叶7天,然后再给药观察各组药物对番泻叶致小鼠腹泻的抑制作用,通过一定时间内观察小鼠湿粪的总粒数作为研究评价指标。
分别将实施例1-2制备的营养药膳粉配制成浓度为3mg/ml的水溶液,将市售的黄连素也配制成浓度为3mg/ml的水溶液,试验1组-试验2组分别按2ml/20g体重灌胃由实施例1-2的营养药膳粉配制成的浓度为3mg/ml的水溶液,对照组按2ml/20g体重灌胃黄连素水溶液,空白对照组灌胃相同体积的蒸馏水,灌胃4小时后单独观察每只小鼠的湿粪计数,以湿粪排出粒数的多少表示腹泻程度,记录各小鼠给药后4小时内的湿粪总数,并计算各药物对番泻叶所致的小鼠腹泻抑制率。
腹泻抑制率的计算公式为:
2.试验结果:
各组治疗后的湿粪计数变化的结果见表1。
表1:各组治疗后的湿粪计数
组别 | 动物数 | 湿粪个数 | 抑制率(%) |
空白对照组 | 10 | 8.2±2.1 | - |
试验1组 | 10 | 2.8±1.6 | 65.85 |
试验2组 | 10 | 2.9±1.8 | 64.63 |
对照组 | 10 | 5.4±2.3 | 34.15 |
由表1可以看出,本发明制备的营养药膳粉的止泻效果显著,对于湿粪的抑制率明显高于对照组。
安全性试验:
急性毒性试验:将本发明实施例1的营养药膳粉与基础日粮混合,制成饲料,取昆明小鼠20只,按250g(营养药膳粉)/kg/d的剂量,连续给药本发明实施例1制备的营养药膳粉7天,无一动物死亡。
长期毒性试验:将本发明实施例1的营养药膳粉与基础日粮混合,制成饲料,取SD大鼠20只,按25g(营养药膳粉)/kg/d的剂量,连续给药本发明实施例1制备的营养药膳粉30天,心、肝、脾、肺、肾等器官未见异常。试验结果表明本发明制备的营养药膳粉安全无毒副作用。
临床试验:
本发明的营养药膳粉对慢性腹泻的治疗效果,可以通过下述临床病例观察得到进一步的证实。
1.临床资料:
以120例已确诊的慢性腹泻患者为观察对象,进行***临床观察,其中男性65例,女性55例,年龄45-80岁,将其随机分为两组,治疗组和对照组,两组在性别、年龄、病程等方面无显著差异。
2.治疗方法:
治疗组给予本发明实施例1制备的营养药膳粉,每天2次,早晚各一次,每次26克,开水冲服;
对照组给予补脾益肠丸(市售产品),每次6克,每天3次。
两组均以15天为一个疗程,4个疗程后评定疗效,停药15天后,根据复发率评定其长期疗效。
3.疗效评价标准:
痊愈:大便正常,腹痛肠鸣和发热等其他症状消失,临床检验正常,停药15天后无复发;
好转:大便次数明显减少,腹痛肠鸣和发热等其他症状改善,停药15天后偶尔复发;
无效:症状未见改善。
4.治疗结果:
治疗组和对照组的治疗结果见表2。
表2:
由表2可以看出,本发明实施例1制备的营养药膳粉能够有效地改善慢性腹泻的主要症状,1-2个疗程起效,食用3-4疗程症状消失,有较好的临床疗效;与对照组药物补脾益肠丸比较,差异显著,且复发率低。
典型病例:
李某,女,年龄63岁,于2015年5月门诊营养咨询。患者自述腹痛腹泻10多年,每日排稀便3~4次,为稀糊样,有时黏液便,伴有乏力,食欲不振,膳食寒性食物症状加重;曾患有子宫肌瘤及卵巢切除术9年、10年,并有萎缩性胃炎。现易出汗,失眠,畏寒,近三年来,出现黎明泄症状,曾就诊西医服用西药治疗效果不明显;服用中医汤剂及参苓白术丸成药等均有一定的效果,但停药后不久又出现腹胀、痛泻症状。其舌质淡、苔薄少。大便检查为稀糊便,余阴性。符合中医肾虚泄泻症状,给予本发明实施例2制备的营养药膳粉,每日早晚各1次,每次26克,以中药液冲为药粥服食,服用营养药膳粉治疗30天后,黎明泄症状,改善为午间及晚间各排便1次,偶见有每日排便3次,失眠、出汗、腹痛症状明显减轻。微调药材后继续服用营养药膳粉治疗20天后,大便成型1~2次,多数症状消失,仍时有腹隐痛症状。又微调中药材,继续营养食疗30天后,腹隐痛及其他症状消失。初期营养食疗期间,限制生冷性及厚味食物,后期可适量选食柿饼、鲜枣等果品,未引发腹痛、腹泻症状。随访1年后,其症状未复发。
Claims (8)
1.一种治疗慢性腹泻的营养药膳粉,其特征在于,由中药组分和食粉按质量比1:(1.5-2)组成;
所述中药组分由以下重量份的原料制成:
黄芪15-20份、党参8-15份、炒白术10-15份、干姜10-15份、血藤5-10份、五味子8-15份、甘草8-15份;
所述食粉由以下重量份的原料制成:
谷粉20-30份;山楂20-25份、茯苓15-20份、大枣10-15份;动物肝粉15-30份;复合水溶性维生素3-6份。
2.如权利要求1所述的营养药膳粉,其特征在于,所述谷粉选自小麦粉、黄豆粉、玉米粉、大米粉、小米粉、燕麦粉中的一种或多种。
3.如权利要求1所述的营养药膳粉,其特征在于,所述复合水溶性维生素由以下重量百分比的组分复配而成:
维生素B1 20-40%、维生素B215-30%、维生素B6 10-25%、维生素C 20-25%。
4.如权利要求3所述的营养药膳粉,其特征在于,所述复合水溶性维生素由以下重量百分比的组分复配而成:
维生素B1 30%、维生素B2 30%、维生素B6 20%、维生素C 20%。
5.权利要求1-4任一项所述的营养药膳粉的制备方法,其特征在于,步骤如下:
(1)中药汁的制备:
将黄芪、党参、炒白术、干姜、血藤、五味子和甘草混合,加水煎煮,滤过,合并滤液,浓缩至相对密度为1.1-1.2(50℃测);
(2)将谷粉、山楂、茯苓、大枣分别炒制,然后与中药汁、动物肝粉和复合水溶性维生素混合均匀,干燥,粉碎,即得营养药膳粉。
6.如权利要求5所述的制备方法,其特征在于,步骤(2)中,所述谷粉的制备方法为:将谷物原料清洗后,加水浸泡30-45分钟,沥干,粉碎,然后进行糊化处理,糊化温度为70-80℃,时间为3-5分钟,干燥,粉碎,过80-100目筛,即得谷粉。
7.权利要求1至4任一项所述的营养药膳粉在制备改善慢性腹泻的保健品或特殊医学用途功能食品中的用途。
8.一种改善慢性腹泻的特殊医学用途功能食品,其特征在于,以权利要求1至3任一项所述的营养药膳粉为有效成分。
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