CN106362199A - Medical adhesive with good antibacterial property and preparation method of medical adhesive - Google Patents
Medical adhesive with good antibacterial property and preparation method of medical adhesive Download PDFInfo
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- CN106362199A CN106362199A CN201610934945.XA CN201610934945A CN106362199A CN 106362199 A CN106362199 A CN 106362199A CN 201610934945 A CN201610934945 A CN 201610934945A CN 106362199 A CN106362199 A CN 106362199A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/104—Gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
The invention discloses a medical adhesive with good antibacterial properties and a preparation method of the medical adhesive. The medical adhesive is prepared from the following raw materials in parts by weight: 30-50 parts of alpha-cyan crylic acid ethyoxyl ethyl ester, 20-25 parts of hydroxypropyl methacrylate, 10-15 parts of epoxy resin, 2-6 parts of pentaerythritol, 1-4 parts of squalane, 6-9 parts of trilaurylamine, 8-12 parts of sepiolite powder, 3-10 parts of sodium alginate, 2-8 parts of glutamine, 2-5 parts of diethylenetriamine, 1-4 parts of sodium silicate, 2-5 parts of calcium oxide, 1-2 parts of rosin, 4-6 parts of gelatin, 4-8 parts of an astragalus extract, 3-5 parts of aluminum silicate ceramic fiber, 3-5 parts of a retarder and 1-3 parts of an antibacterial agent. The medical adhesive disclosed by the invention is good in antibacterial property, high in viscosity, safe and stable and good in antibacterial effect.
Description
Technical field
The present invention relates to biomedical materials field, it is related specifically to the strong adhesive of medical of antibiotic property and its preparation side
Method.
Background technology
Adhesive of medical, in general has treatment and auxiliary therapeutic action, or can process medical supplies and medical auxiliary
The glue class of material is referred to as adhesive of medical.Adhesive of medical belongs to biomedical specific functionality binding agent, except having generally
Splicing function and mechanics function outside, also should have Biomedical function, in the world for manufacture with human physiological environment (
Tissue and blood etc.) medical supplies that contact are referred to as bio-medical engineering material.Preferably adhesive of medical should be expired
Foot: 1. safe and nontoxic, no carcinogenic, teratogenesis, mutagenesis;2. bonding strength is good;3. can quick with tissue glued joint under normal temperature and pressure;
4. good biocompatibility;5. itself is aseptic and energy is antibacterial;When 6. solidifying, caloric value is few, in order to avoid scalded tissue;7. it is difficult to form blood
Bolt;8. can gradually degrade in tissue, absorb, drain.
Adhesive of medical species is various at present, of many uses, has broad prospects, but all kinds of binding agent always has endless
The place of people's will, but still need to solve a lot of problems, this will lean on further effort to explore and develop.For example, cyanoacrylate
Class compound has the advantages that it is unique when using as adhesive of medical, but remains on and there are some very important asking
Inscribe although the bonding time is short, but glue-line fragility is big, unavoidably produces formaldehyde during decomposition;Tooth binding agent is easily subject to temperature, strong
Degree, the impact of physiological environment factor and be easily caused cementation loosely etc..And a kind of withered dose of preferable medical adhesive is in a humid environment
In the presence of in dense lipoid, adhesive power will height, binding agent and its catabolite should be nontoxic, not carcinogenic, teratogenesis, cause prominent
Become, do not have and exempt from originality.For soft tissue adhesives it is therefore desirable to complete biodegradable, and absorbed, metabolism goes out in vitro, also simultaneously
There is antibacterial and sterilization capability, requirements above can be reached and widely used binding agent seldom major part is also in research and development rank
Section is in addition it is also necessary to people further make great efforts to explore and develop, and it is current for reducing its side effect to greatest extent with modified method
The focus of adhesive of medical research.
Content of the invention
For solving above-mentioned technical problem, the present invention provides strong adhesive of medical of a kind of antibiotic property and preparation method thereof, leads to
Cross and be combined using specified raw material, coordinate corresponding production technology, the strong adhesive of medical of the antibiotic property obtaining, its viscosity
High, safety and stability, has antibacterial effect, disclosure satisfy that the requirement of industry, have preferable application prospect.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of strong adhesive of medical of antibiotic property, is prepared by the raw materials in: ethoxy ethyl ester alpha-cyanoacrylate 30-
50 parts, Hydroxypropyl methacrylate 20-25 part, epoxy resin 10-15 part, tetramethylolmethane 2-6 part, squalane 1-4 part, three Laurels
Amine 6-9 part, sepiolite powder 8-12 part, sodium alginate 3-10 part, L-Glutamine 2-8 part, diethylenetriamine 2-5 part, sodium silicate 1-4
Part, calcium oxide 2-5 part, Colophonium 1-2 part, gelatin 4-6 part, Radix Astragali extract 4-8 part, alumina-silicate ceramic fibre 3-5 part, retarder
3-5 part, antibacterial 1-3 part.
Preferably, described retarder be tartaric acid, gluconic acid, salicylic acid, any one in sodium lignin sulfonate.
Preferably, described antibacterial is selected from chitosan polysaccharide, Oleum Ricini, benzyldimethyldodecylammonium base chlorination
Any one or a few in ammonium, isopropanol.
The preparation method of the strong adhesive of medical of described antibiotic property, comprises the following steps:
(1) weigh each raw material according to weight portion；
(2) by ethoxy ethyl ester alpha-cyanoacrylate, Hydroxypropyl methacrylate, epoxy resin, sepiolite powder, gelatin, the Radix Astragali
Extract, alumina-silicate ceramic fibre mixing, are added in ultrasonic disintegrator, and grinding time is 20-40 minute, and supersonic frequency is
220-250kw；
(3) the Ultrasonic Pulverization thing in step (2) is sieved, remove bulky grain, cross mesh size and be 50-100 μm；
(4) sieving of step (3) is placed in mixing and blending machine, sequentially adds squalane, sodium alginate, glutamy simultaneously
Amine, calcium oxide, sodium silicate, Colophonium, mix homogeneously at a temperature of 360-400 DEG C, add tetramethylolmethane, March after being cooled to room temperature
Osmanthus amine, diethylenetriamine, retarder, obtain whole batch mixing, are subsequently placed in drying baker and are dried, and are cooled to room temperature；
(5) by the whole batch mixing injection banbury after cooling, it is simultaneously introduced antibacterial, the response time is 45-60 minute, reaction temperature
Spend for 180-220 DEG C；
(6) reactant in step (5) is cooled to room temperature as under inert gas environment；
(7) by the refrigerant of step (6) through ultraviolet irradiation sterilizing after subpackage, seal, be packaged to be finished product.
Preferably, described noble gases are nitrogen.
Compared with prior art, its advantage is the present invention:
(1) the strong adhesive of medical of the antibiotic property of the present invention, with ethoxy ethyl ester alpha-cyanoacrylate, methacrylic acid hydroxypropyl
Ester, epoxy resin, sepiolite powder, gelatin, Radix Astragali extract, alumina-silicate ceramic fibre be main component, by add squalane,
Sodium alginate, L-Glutamine, calcium oxide, sodium silicate, Colophonium, tetramethylolmethane, Alamine 304, diethylenetriamine, retarder, antibacterial
Agent, be aided with the techniques such as Ultrasonic Pulverization, screening of sieving, high-temperature stirring, cool drying, high temperature banburying, irradiation sterilization so that preparation and
The strong adhesive of medical of antibiotic property becoming, its viscosity is high, safety and stability, has antibacterial effect, disclosure satisfy that the requirement of industry, tool
There is preferable application prospect.
(2) the strong adhesive of medical raw material of the antibiotic property of the present invention is cheap, process is simple, is suitable to heavy industrialization fortune
With practical.
Specific embodiment
With reference to specific embodiment, the technical scheme of invention is described in detail.
Embodiment 1
(1) 30 parts of ethoxy ethyl ester alpha-cyanoacrylate, 20 parts of Hydroxypropyl methacrylate, epoxy resin are weighed according to weight portion
10 parts, 2 parts of tetramethylolmethane, 1 part of squalane, 6 parts of Alamine 304,8 parts of sepiolite powder, 3 parts of sodium alginate, 2 parts of L-Glutamine, two
2 parts of ethylene triamine, 1 part of sodium silicate, 2 parts of calcium oxide, 1 part of Colophonium, 4 parts of gelatin, 4 parts of Radix Astragali extract, alumina-silicate ceramic fibre 3
Part, 3 parts of tartaric acid, 1 part of chitosan polysaccharide；
(2) by ethoxy ethyl ester alpha-cyanoacrylate, Hydroxypropyl methacrylate, epoxy resin, sepiolite powder, gelatin, the Radix Astragali
Extract, alumina-silicate ceramic fibre mixing, are added in ultrasonic disintegrator, and grinding time is 20 minutes, and supersonic frequency is
220kw；
(3) the Ultrasonic Pulverization thing in step (2) is sieved, remove bulky grain, cross mesh size and be 50 μm；
(4) sieving of step (3) is placed in mixing and blending machine, sequentially adds squalane, sodium alginate, glutamy simultaneously
Amine, calcium oxide, sodium silicate, Colophonium, mix homogeneously at a temperature of 360 DEG C, add tetramethylolmethane, three Laurels after being cooled to room temperature
Amine, diethylenetriamine, tartaric acid, obtain whole batch mixing, are subsequently placed in drying baker and are dried, and are cooled to room temperature；
(5) by the whole batch mixing injection banbury after cooling, it is simultaneously introduced chitosan polysaccharide, the response time is 45 points
Clock, reaction temperature is 180 DEG C；
(6) reactant in step (5) is cooled to room temperature as under nitrogen environment；
(7) by the refrigerant of step (6) through ultraviolet irradiation sterilizing after subpackage, seal, be packaged to be finished product.
The performance test results of the strong adhesive of medical of prepared antibiotic property are as shown in table 1.
Embodiment 2
(1) 35 parts of ethoxy ethyl ester alpha-cyanoacrylate, 22 parts of Hydroxypropyl methacrylate, epoxy resin are weighed according to weight portion
12 parts, 3 parts of tetramethylolmethane, 2 parts of squalane, 7 parts of Alamine 304,10 parts of sepiolite powder, 5 parts of sodium alginate, 4 parts of L-Glutamine,
3 parts of diethylenetriamine, 2 parts of sodium silicate, 3 parts of calcium oxide, 1 part of Colophonium, 4 parts of gelatin, 5 parts of Radix Astragali extract, aluminum silicate ceramic are fine
4 parts of dimension, 4 parts of gluconic acid, 2 parts of Oleum Ricini；
(2) by ethoxy ethyl ester alpha-cyanoacrylate, Hydroxypropyl methacrylate, epoxy resin, sepiolite powder, gelatin, the Radix Astragali
Extract, alumina-silicate ceramic fibre mixing, are added in ultrasonic disintegrator, and grinding time is 25 minutes, and supersonic frequency is
230kw；
(3) the Ultrasonic Pulverization thing in step (2) is sieved, remove bulky grain, cross mesh size and be 70 μm；
(4) sieving of step (3) is placed in mixing and blending machine, sequentially adds squalane, sodium alginate, glutamy simultaneously
Amine, calcium oxide, sodium silicate, Colophonium, mix homogeneously at a temperature of 370 DEG C, add tetramethylolmethane, three Laurels after being cooled to room temperature
Amine, diethylenetriamine, gluconic acid, obtain whole batch mixing, are subsequently placed in drying baker and are dried, and are cooled to room temperature；
(5) by the whole batch mixing injection banbury after cooling, it is simultaneously introduced Oleum Ricini, the response time is 50 minutes, reaction temperature
For 190 DEG C；
(6) reactant in step (5) is cooled to room temperature as under nitrogen environment；
(7) by the refrigerant of step (6) through ultraviolet irradiation sterilizing after subpackage, seal, be packaged to be finished product.
The performance test results of the strong adhesive of medical of prepared antibiotic property are as shown in table 1.
Embodiment 3
(1) 45 parts of ethoxy ethyl ester alpha-cyanoacrylate, 24 parts of Hydroxypropyl methacrylate, epoxy resin are weighed according to weight portion
14 parts, 5 parts of tetramethylolmethane, 3 parts of squalane, 8 parts of Alamine 304,11 parts of sepiolite powder, 8 parts of sodium alginate, 6 parts of L-Glutamine,
4 parts of diethylenetriamine, 3 parts of sodium silicate, 4 parts of calcium oxide, 2 parts of Colophonium, 5 parts of gelatin, 7 parts of Radix Astragali extract, aluminum silicate ceramic are fine
4 parts of dimension, 4 parts of salicylic acid, 2 parts of benzyldimethyldodecylammonium ammonium chloride；
(2) by ethoxy ethyl ester alpha-cyanoacrylate, Hydroxypropyl methacrylate, epoxy resin, sepiolite powder, gelatin, the Radix Astragali
Extract, alumina-silicate ceramic fibre mixing, are added in ultrasonic disintegrator, and grinding time is 35 minutes, and supersonic frequency is
240kw；
(3) the Ultrasonic Pulverization thing in step (2) is sieved, remove bulky grain, cross mesh size and be 90 μm；
(4) sieving of step (3) is placed in mixing and blending machine, sequentially adds squalane, sodium alginate, glutamy simultaneously
Amine, calcium oxide, sodium silicate, Colophonium, mix homogeneously at a temperature of 390 DEG C, add tetramethylolmethane, three Laurels after being cooled to room temperature
Amine, diethylenetriamine, salicylic acid, obtain whole batch mixing, are subsequently placed in drying baker and are dried, and are cooled to room temperature；
(5) by the whole batch mixing injection banbury after cooling, it is simultaneously introduced benzyldimethyldodecylammonium ammonium chloride, response time
For 55 minutes, reaction temperature was 210 DEG C；
(6) reactant in step (5) is cooled to room temperature as under nitrogen environment；
(7) by the refrigerant of step (6) through ultraviolet irradiation sterilizing after subpackage, seal, be packaged to be finished product.
The performance test results of the strong adhesive of medical of prepared antibiotic property are as shown in table 1.
Embodiment 4
(1) 50 parts of ethoxy ethyl ester alpha-cyanoacrylate, 25 parts of Hydroxypropyl methacrylate, epoxy resin are weighed according to weight portion
15 parts, 6 parts of tetramethylolmethane, 4 parts of squalane, 9 parts of Alamine 304,12 parts of sepiolite powder, 10 parts of sodium alginate, 8 parts of L-Glutamine,
5 parts of diethylenetriamine, 4 parts of sodium silicate, 5 parts of calcium oxide, 2 parts of Colophonium, 6 parts of gelatin, 8 parts of Radix Astragali extract, aluminum silicate ceramic are fine
5 parts of dimension, 5 parts of sodium lignin sulfonate, 3 parts of isopropanol；
(2) by ethoxy ethyl ester alpha-cyanoacrylate, Hydroxypropyl methacrylate, epoxy resin, sepiolite powder, gelatin, the Radix Astragali
Extract, alumina-silicate ceramic fibre mixing, are added in ultrasonic disintegrator, and grinding time is 40 minutes, and supersonic frequency is
250kw；
(3) the Ultrasonic Pulverization thing in step (2) is sieved, remove bulky grain, cross mesh size and be 100 μm；
(4) sieving of step (3) is placed in mixing and blending machine, sequentially adds squalane, sodium alginate, glutamy simultaneously
Amine, calcium oxide, sodium silicate, Colophonium, mix homogeneously at a temperature of 400 DEG C, add tetramethylolmethane, three Laurels after being cooled to room temperature
Amine, diethylenetriamine, sodium lignin sulfonate, obtain whole batch mixing, are subsequently placed in drying baker and are dried, and are cooled to room temperature；
(5) by the whole batch mixing injection banbury after cooling, it is simultaneously introduced isopropanol, the response time is 60 minutes, reaction temperature
For 220 DEG C；
(6) reactant in step (5) is cooled to room temperature as under nitrogen environment；
(7) by the refrigerant of step (6) through ultraviolet irradiation sterilizing after subpackage, seal, be packaged to be finished product.
The performance test results of the strong adhesive of medical of prepared antibiotic property are as shown in table 1.
Comparative example 1
(1) 30 parts of ethoxy ethyl ester alpha-cyanoacrylate, 20 parts of Hydroxypropyl methacrylate, epoxy resin are weighed according to weight portion
10 parts, 2 parts of tetramethylolmethane, 1 part of squalane, 6 parts of Alamine 304,3 parts of sodium alginate, 2 parts of L-Glutamine, 2 parts of diethylenetriamine,
1 part of sodium silicate, 1 part of Colophonium, 4 parts of gelatin, 4 parts of Radix Astragali extract, 3 parts of alumina-silicate ceramic fibre, 3 parts of tartaric acid, deacetylated shell
1 part of polysaccharide polysaccharide；
(2) by ethoxy ethyl ester alpha-cyanoacrylate, Hydroxypropyl methacrylate, epoxy resin, gelatin, Radix Astragali extract, silicon
Sour aluminum ceramic fibre mixing, is added in ultrasonic disintegrator, and grinding time is 20 minutes, and supersonic frequency is 220kw；
(3) the Ultrasonic Pulverization thing in step (2) is sieved, remove bulky grain, cross mesh size and be 50 μm；
(4) sieving of step (3) is placed in mixing and blending machine, sequentially adds squalane, sodium alginate, glutamy simultaneously
Amine, sodium silicate, Colophonium, mix homogeneously at a temperature of 360 DEG C, add tetramethylolmethane, Alamine 304, divinyl after being cooled to room temperature
Triamine, tartaric acid, obtain whole batch mixing, are subsequently placed in drying baker and are dried, and are cooled to room temperature；
(5) by the whole batch mixing injection banbury after cooling, it is simultaneously introduced chitosan polysaccharide, the response time is 45 points
Clock, reaction temperature is 180 DEG C；
(6) reactant in step (5) is cooled to room temperature as under nitrogen environment；
(7) by the refrigerant of step (6) through ultraviolet irradiation sterilizing after subpackage, seal, be packaged to be finished product.
The performance test results of the strong adhesive of medical of prepared antibiotic property are as shown in table 1.
Comparative example 2
(1) 50 parts of ethoxy ethyl ester alpha-cyanoacrylate, 25 parts of Hydroxypropyl methacrylate, epoxy resin are weighed according to weight portion
15 parts, 6 parts of tetramethylolmethane, 4 parts of squalane, 9 parts of Alamine 304,12 parts of sepiolite powder, 10 parts of sodium alginate, 8 parts of L-Glutamine,
5 parts of calcium oxide, 2 parts of Colophonium, 6 parts of gelatin, 8 parts of Radix Astragali extract, 5 parts of alumina-silicate ceramic fibre, 5 parts of sodium lignin sulfonate, different
3 parts of propanol；
(2) by ethoxy ethyl ester alpha-cyanoacrylate, Hydroxypropyl methacrylate, epoxy resin, sepiolite powder, gelatin, the Radix Astragali
Extract, alumina-silicate ceramic fibre mixing, are added in ultrasonic disintegrator, and grinding time is 40 minutes, and supersonic frequency is
250kw；
(3) the Ultrasonic Pulverization thing in step (2) is sieved, remove bulky grain, cross mesh size and be 100 μm；
(4) sieving of step (3) is placed in mixing and blending machine, sequentially adds squalane, sodium alginate, glutamy simultaneously
Amine, calcium oxide, Colophonium, mix homogeneously at a temperature of 400 DEG C, add tetramethylolmethane, Alamine 304, lignin after being cooled to room temperature
Sodium sulfonate, obtains whole batch mixing, is subsequently placed in drying baker and is dried, and is cooled to room temperature；
(5) by the whole batch mixing injection banbury after cooling, it is simultaneously introduced isopropanol, the response time is 60 minutes, reaction temperature
For 220 DEG C；
(6) reactant in step (5) is cooled to room temperature as under nitrogen environment；
(7) by the refrigerant of step (6) through ultraviolet irradiation sterilizing after subpackage, seal, be packaged to be finished product.
The performance test results of the strong adhesive of medical of prepared antibiotic property are as shown in table 1.
Adhesive of medical strong for the prepared antibiotic property of embodiment 1-4 and comparative example 1-2 is carried out adhesion strength, Intradermal thorn
Sharp property test, scratch test and stretching this several performance tests of shearing strength.
Table 1
| Adhesion strength (n) | Intradermal zest is tested | Scratch test | Stretching shearing strength (mpa) | |
| Embodiment 1 | 74.22 | Qualified | Qualified | 35.6 |
| Embodiment 2 | 71.85 | Qualified | Qualified | 36.4 |
| Embodiment 3 | 76.89 | Qualified | Qualified | 36.2 |
| Embodiment 4 | 72.64 | Qualified | Qualified | 35.9 |
| Comparative example 1 | 50.83 | Qualified | Qualified | 12.5 |
| Comparative example 2 | 47.67 | Qualified | Qualified | 17.1 |
The strong adhesive of medical of the antibiotic property of the present invention, with ethoxy ethyl ester alpha-cyanoacrylate, Hydroxypropyl methacrylate, ring
Oxygen tree fat, sepiolite powder, gelatin, Radix Astragali extract, alumina-silicate ceramic fibre are main component, by adding squalane, Sargassum
Sour sodium, L-Glutamine, calcium oxide, sodium silicate, Colophonium, tetramethylolmethane, Alamine 304, diethylenetriamine, retarder, antibacterial,
It is aided with the techniques such as Ultrasonic Pulverization, screening of sieving, high-temperature stirring, cool drying, high temperature banburying, irradiation sterilization so that being prepared from
The strong adhesive of medical of antibiotic property, its viscosity is high, safety and stability, has antibacterial effect, disclosure satisfy that the requirement of industry, have
Preferably application prospect.The adhesive of medical raw material that the antibiotic property of the present invention is strong is cheap, process is simple, is suitable to heavy industrialization
With practical.
The foregoing is only embodiments of the invention, not thereby limit the present invention the scope of the claims, every using this
Equivalent structure or equivalent flow conversion that bright description is made, or directly or indirectly it is used in other related technology necks
Domain, is included within the scope of the present invention.
Claims (5)
1. a kind of strong adhesive of medical of antibiotic property it is characterised in that: be prepared by the raw materials in: alpha-cyanoacrylate
Ethoxy ethyl ester 30-50 part, Hydroxypropyl methacrylate 20-25 part, epoxy resin 10-15 part, tetramethylolmethane 2-6 part, spiny dogfish
Alkane 1-4 part, Alamine 304 6-9 part, sepiolite powder 8-12 part, sodium alginate 3-10 part, L-Glutamine 2-8 part, diethylenetriamine
2-5 part, sodium silicate 1-4 part, calcium oxide 2-5 part, Colophonium 1-2 part, gelatin 4-6 part, Radix Astragali extract 4-8 part, aluminum silicate ceramic
Fiber 3-5 part, retarder 3-5 part, antibacterial 1-3 part.
2. the strong adhesive of medical of antibiotic property according to claim 1 it is characterised in that: described retarder be tartaric acid,
Any one in gluconic acid, salicylic acid, sodium lignin sulfonate.
3. the strong adhesive of medical of antibiotic property according to claim 1 it is characterised in that: described antibacterial be selected from deacetylated
Any one or a few in chitosan polysaccharide, Oleum Ricini, benzyldimethyldodecylammonium ammonium chloride, isopropanol.
4. the preparation method according to the strong adhesive of medical of the arbitrary described antibiotic property of claims 1 to 3 is it is characterised in that wrap
Include following steps:
(1) weigh each raw material according to weight portion；
(2) by ethoxy ethyl ester alpha-cyanoacrylate, Hydroxypropyl methacrylate, epoxy resin, sepiolite powder, gelatin, the Radix Astragali
Extract, alumina-silicate ceramic fibre mixing, are added in ultrasonic disintegrator, and grinding time is 20-40 minute, and supersonic frequency is
220-250kw；
(3) the Ultrasonic Pulverization thing in step (2) is sieved, remove bulky grain, cross mesh size and be 50-100 μm；
(4) sieving of step (3) is placed in mixing and blending machine, sequentially adds squalane, sodium alginate, glutamy simultaneously
Amine, calcium oxide, sodium silicate, Colophonium, mix homogeneously at a temperature of 360-400 DEG C, add tetramethylolmethane, March after being cooled to room temperature
Osmanthus amine, diethylenetriamine, retarder, obtain whole batch mixing, are subsequently placed in drying baker and are dried, and are cooled to room temperature；
(5) by the whole batch mixing injection banbury after cooling, it is simultaneously introduced antibacterial, the response time is 45-60 minute, reaction temperature
Spend for 180-220 DEG C；
(6) reactant in step (5) is cooled to room temperature as under inert gas environment；
(7) by the refrigerant of step (6) through ultraviolet irradiation sterilizing after subpackage, seal, be packaged to be finished product.
5. the strong adhesive of medical of antibiotic property according to claim 4 preparation method it is characterised in that: described indifferent gas
Body is nitrogen.
Priority Applications (1)
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| CN201610934945.XA CN106362199A (en) | 2016-11-01 | 2016-11-01 | Medical adhesive with good antibacterial property and preparation method of medical adhesive |
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| CN201610934945.XA CN106362199A (en) | 2016-11-01 | 2016-11-01 | Medical adhesive with good antibacterial property and preparation method of medical adhesive |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107890584A (en) * | 2017-11-29 | 2018-04-10 | 广西众昌树脂有限公司 | Medical adhesive composition |
| CN108686257A (en) * | 2018-06-21 | 2018-10-23 | 浙江派菲特新材料科技有限公司 | A kind of high anti-microbial property adhesive of medical |
| CN113572319A (en) * | 2021-07-08 | 2021-10-29 | 江苏集萃安泰创明先进能源材料研究院有限公司 | Radial amorphous iron core and preparation method thereof |
| CN114467973A (en) * | 2022-01-07 | 2022-05-13 | 台山市新建业（药用）五金包装有限公司 | Nano-silver antibacterial material for food-grade and/or medical-grade packaging material and preparation method thereof |
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| CN104399113A (en) * | 2014-11-25 | 2015-03-11 | 苏州市贝克生物科技有限公司 | Adhesive for soft tissues and preparation method of adhesive |
| CN104704073A (en) * | 2012-05-18 | 2015-06-10 | 3M创新有限公司 | Adhesive articles for medical applications |
| CN105194723A (en) * | 2015-09-25 | 2015-12-30 | 苏州蔻美新材料有限公司 | Antibacterial orthopedic adhesive and preparation method thereof |
| CN105963767A (en) * | 2014-11-07 | 2016-09-28 | 吴杰 | Preparation method for medical adhesive adopting medical macromolecular material |
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| CN104704073A (en) * | 2012-05-18 | 2015-06-10 | 3M创新有限公司 | Adhesive articles for medical applications |
| CN105963767A (en) * | 2014-11-07 | 2016-09-28 | 吴杰 | Preparation method for medical adhesive adopting medical macromolecular material |
| CN104399113A (en) * | 2014-11-25 | 2015-03-11 | 苏州市贝克生物科技有限公司 | Adhesive for soft tissues and preparation method of adhesive |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107890584A (en) * | 2017-11-29 | 2018-04-10 | 广西众昌树脂有限公司 | Medical adhesive composition |
| CN108686257A (en) * | 2018-06-21 | 2018-10-23 | 浙江派菲特新材料科技有限公司 | A kind of high anti-microbial property adhesive of medical |
| CN113572319A (en) * | 2021-07-08 | 2021-10-29 | 江苏集萃安泰创明先进能源材料研究院有限公司 | Radial amorphous iron core and preparation method thereof |
| CN114467973A (en) * | 2022-01-07 | 2022-05-13 | 台山市新建业（药用）五金包装有限公司 | Nano-silver antibacterial material for food-grade and/or medical-grade packaging material and preparation method thereof |
| CN114467973B (en) * | 2022-01-07 | 2024-05-14 | 台山市新建业（药用）五金包装有限公司 | Nano silver antibacterial material for food-grade and/or medical-grade packaging materials and preparation method thereof |
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