CN106361758B - A kind of compound ivermectin praziquantel two-arch tunnel emulsion and preparation method thereof - Google Patents
A kind of compound ivermectin praziquantel two-arch tunnel emulsion and preparation method thereof Download PDFInfo
- Publication number
- CN106361758B CN106361758B CN201610773785.5A CN201610773785A CN106361758B CN 106361758 B CN106361758 B CN 106361758B CN 201610773785 A CN201610773785 A CN 201610773785A CN 106361758 B CN106361758 B CN 106361758B
- Authority
- CN
- China
- Prior art keywords
- praziquantel
- emulsion
- ivermectin
- arch tunnel
- emulsifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A kind of compound ivermectin praziquantel two-arch tunnel emulsion, the weight of every 100g emulsion forms are as follows: 0.1~2g of ivermectin, 0.1~25g of praziquantel, 0.01~3g of Arecoline hydrobromide, 1~10g of solvent naphtha, 0.1~5g of cosolvent, 20~30g of emulsifier, 10~20g of assistant for emulsifying agent, surplus are deionized water.Emulsion prepared by the present invention, pest-resistant spectrum is wide, significant in efficacy, can both be used with injecting after oil dilution when use, drinking water or injecting after can also being diluted with water uses, according to clinical concrete condition flexible choice.The present invention further discloses preparation method simultaneously, and process operability is strong, is conducive to conversion.
Description
Technical field
The invention belongs to veterinary medicine technical fields, and in particular to a kind of compound ivermectin praziquantel two-arch tunnel emulsion
And preparation method thereof.
Background technique
Animal parasitosis is common transmittable disease during livestock and poultry cultivation, and wherein nematode, tapeworm, fluke and insects are parasitic
Worm incidence rate almost accounts for 80% or more, is veterinary clinic common disease and frequently-occurring disease.After livestock and poultry infect helminth, polypide is in host
Breeding in vivo, development, absorb animal endotrophic, and the nutrition that animal eats is utilized by helminth, and appearance is thin, and nutrition is not
It is good, seriously affect Production of Livestock and Poultry level.Some insects helminths can also cause part other than causing raising poultry nutritive bad
It festers, bleeding, serious secondary infection, and other epidemic diseases can be broken out, seriously threaten livestock birds health.
For the generation of prevention and control parasitic disease, need periodically to carry out expelling parasite to animal in production, health expelling parasite needs wide
The anthelmintic of spectrum, but the drug that few all types helminths are all killed at present.Therefore, generally mostly cooperated using several drugs
Use, such as drive nematode, the ivermectin of insect and the praziquantel of expelling tenia, fluke are used cooperatively, curative effect highly significant and when
Under a kind of popular expelling parasite scheme.
Ivermectin belongs to Avermectins nematocide, mainly enhancing invertebrate nerve synapse caudacoria to chlorine from
The permeability of son finally makes the neural paralysis of polypide and lethal so that block nerves signal transmits.Insecticidal action mainly passes through two
Different approach is planted to enhance neu to chloride ion permeability, one is inhibiting by enhancing invertebrate peripheral nerve
The release of neurotransmitter GABA；The second is causing the chloride channel controlled by glutamic acid open.Since mammal does not have
The chloride channel of glutamic acid control, therefore mammal is used comparatively safe.Ivermectin is to nematode, insects helminth
With efficiently killing effect, and dosage is seldom, and per kilogram of body weight about 2~3mg can reach ideal effect.
Praziquantel is clinically common expelling tenia, Trematoda drug, and appearance is white or off-white powder, and bitter, which has, to be drawn
It is moist.After taking, blood fluke in host can be made to generate spastic paralysis and fall off, and migrate to liver.To most of tapeworms
Adult and prematurity polypide are effective, in addition minimum to animal toxicity, are highly desirable drugs.Its pest-resistant mechanism is to blood fluke
There is the effect of 5-TH sample, causes polypide spastic paralysis；Polypide sarcoplasm film can be influenced to calcium ion permeability simultaneously, be calcium ion
Interior stream increases, and keeps polypide dead.Praziquantel toxicity is also very low, and application is safe.
Currently, praziquantel dosage form is concentrated mainly on tablet, pulvis, liquid preparation is fewer, has in document to liquid dosage form
The report of research, but universal drugloading rate is not high, and clinically the compound praziquantel liquid preparation of high-content is in great demand, Yi Wei
Though rhzomorph has liquid preparation, single use is only effective to nematode and insects helminth, if being able to cooperate anti-tapeworm and fluke
Praziquantel use, a drug, a variety of polypides all kill, certainly will have a wide range of applications.
For above situation, need one kind that can compound ivermectin praziquantel together in the market, and stability is strong,
Drugloading rate high liquid preparation is covered the shortage.
Summary of the invention
The purpose of the present invention is to provide a kind of compound ivermectin praziquantel two-arch tunnel emulsions, while providing its preparation
Method is another goal of the invention of the invention.
Based on above-mentioned purpose, the present invention is adopted the following technical scheme that: a kind of compound ivermectin praziquantel two-arch tunnel cream
Agent, the weight composition of every 100g emulsion are as follows: 0.1~2g of ivermectin, 0.1~25g of praziquantel, Arecoline hydrobromide 0.01~
3g, 1.0~10g of solvent naphtha, 0.1~5g of cosolvent, 20~30g of emulsifier, 10~20g of assistant for emulsifying agent, surplus are deionized water.
Preferably, the weight composition of every 100g emulsion are as follows: 0.5~1g of ivermectin, 5~20g of praziquantel, hydrobromic acid betel nut
1.0~2g of alkali, 3~8g of solvent naphtha, 2~4g of cosolvent, 23~28g of emulsifier, 12~18g of assistant for emulsifying agent, surplus are deionization
Water.
Preferably, the weight composition of every 100g emulsion are as follows: ivermectin 1g, praziquantel 15g, Arecoline hydrobromide 1.5g,
Solvent naphtha 6g, cosolvent 3g, emulsifier 25g, assistant for emulsifying agent 15g, surplus are deionized water.
Preferably, the solvent naphtha is ethyl acetate, in isopropyl myristate, injection soybean oil, ethyl oleate
One or two kinds of mixtures.
Preferably, the cosolvent is N, N- dimethyl propylene alkenyl urea.
Preferably, the emulsifier be one of Tween-81, Tween-40, Tween-80 in Arlacel-80, Arlacel-85
A kind of compounding after mixed surfactant.
Preferably, the assistant for emulsifying agent be dehydrated alcohol, 1,2-PD, polyethylene glycol 200 or glycerine one kind or
Two kinds of mixtures.
Preferably, the deionized water is sterile deionized water.
The preparation method of the compound ivermectin praziquantel two-arch tunnel emulsion, comprising the following steps: (a) is first by her
Dimension rhzomorph, praziquantel are mixed with solvent naphtha, sequentially add cosolvent, emulsifier mixes to obtain system 1；(b) by Arecoline hydrobromide
It is dissolved in deionized water, assistant for emulsifying agent mixing is added, obtains system 2；(c) system 1 is heated to 60~80 DEG C, delayed at this temperature
Slow that system 2 is added, stirring while adding, system is by dilute retrogradation, after system 2 is added completely into, continue to stir and maintain temperature 60~
80 DEG C of at least 30min, stop stirring later, and standing is cooled to room temperature to obtain the final product.
Reasonable recipe of the present invention has pest-resistant spectrum width, Nemata, tapeworms, suction for livestock and poultry inside and outside parasitic treatments
Insects and insects helminth kill effect, and use is safe, curative for effect.
The non-oil-in-water type of emulsion feature prepared by the present invention nor water-in-oil type, but the bicontinuous that grease dissolves each other, face
Bed in use, can with oil dilution after injection, after can also being diluted with water drinking-water or injection, can according to clinic need with
Machine strain.
In prescription of the present invention, each component is in the effect wherein played are as follows:
1) ivermectin, praziquantel and the Arecoline hydrobromide selected are directed to Nemata as pharmaceutical composition, ivermectin
It is very strong that effect is killed with insects helminth, and praziquantel kills effect ideal, hydrobromic acid betel nut to tapeworms and Trematoda
Alkali can assist killing helminth, and prescription expelling parasite spectrum is wide, and especially to the regular expelling parasite health care of livestock and poultry, clinical effectiveness is significant；
2) present invention selection Tweens and spans surfactant are used cooperatively, and are because both surfactants are matched
Under conjunction, it is especially advantageous for forming stable two-arch tunnel emulsion；
3) N that the present invention selects, N- dimethyl propylene alkenyl urea are cosolvent, can increase drug solubility, prevent high load medicine
There is drug precipitation phenomenon in later period placement process in the praziquantel of amount, and the selection of cosolvent is also prescription wound of the invention
New point.
Other than prescription advantage, simple process of the invention does not need to introduce complicated equipment, general veterinary drug enterprises
The workshop GMP can produce, therefore production cost is low, be conducive to a wide range of popularization of drug.
Compared with prior art, the present invention passing through the improvement of prescription and technique, the technical effect reached are as follows: firstly, this hair
Bright emulsion pest-resistant spectrum is wide, and use is safe, and property is stablized, significant in efficacy；Secondly, emulsion prepared by the present invention is two-arch tunnel,
, can be with injection after oil dilution when clinical use, drinking-water or injection after can also being diluted with water can be according to clinical needs
It adjusts to changed conditions, it is easy to use.Furthermore preparation process strong operability of the invention, utilizes conversion.
Detailed description of the invention
Fig. 1 is the electron micrograph of two-arch tunnel emulsion made from the embodiment of the present invention 1；(HV=80.0kv,
Direct Mag:5000x).
Specific embodiment
The present invention will be illustrated by embodiment below, but these specific embodiments do not limit this hair in any way
Bright protection scope.
Embodiment 1-10
To keep specification succinct, it is double to provide compound ivermectin praziquantel described in embodiment 1-10 in the form of a table below
The weight of continuous phase emulsion forms, and is specifically shown in Table 1.
The preparation method of compound ivermectin praziquantel two-arch tunnel emulsion described in embodiment 1-10, including following step
It is rapid:
(a) ivermectin, praziquantel and solvent naphtha are uniformly mixed, cosolvent is added and stirs evenly, adds emulsifier
It stirs evenly, obtains system 1；
(b) Arecoline hydrobromide is dissolved in deionized water, adds assistant for emulsifying agent, stirred evenly, obtain system 2；
(c) system 1 is heated to 70 DEG C, and maintains constant temperature, be slowly added to system 2 at this time, stirring while adding, system is by dilute
Retrogradation continues to stir and maintains temperature 70 C 40min after being added to system 2, stops stirring later, and standing is cooled to room
Temperature to obtain the final product.
In other embodiments, it as long as the temperature of system meets between 60~80 DEG C in step (c), is added to system 2
After continue to time at least 30min effect of the invention can be achieved.
The weight of 1 embodiment 1-10 of table forms (total 100g)
。
Test example
The product property of 1 product of the present invention of test example and stability test
Electronic Speculum observation is scanned to the product of embodiment 1-10 preparation, as shown in Figure 1, it will be seen from figure 1 that the present invention
Emulsion obtained is in water phase and oily phase two-arch tunnel distribution.
The appearance for the product that the present invention obtains is the uniform faint yellow or yellow liquid of quality, to the embodiment of the present invention 1-
10 are sampled, and carry out room temperature respectively to each embodiment, 40 DEG C of high temperature and humidity are placed, 4 DEG C of low temperature are placed and -20 DEG C cold
Freeze and place, and separately sampled observation character when 0d, 15d, 30d, 90d and 180d, as a result, it has been found that, the product that each embodiment obtains
Situation is precipitated without layering and drug, there is preferable stability.
The safety testing of 2 product of the present invention of test example
The safety used below by way of clinical trial verifying drug.
Kun Ming mice 80 for choosing 20g or so, points 4 groups, every group 20, first group is control group, the 2nd, 3,4 group
For high, medium and low dosage group of the invention.By taking embodiment 1 as an example, respectively to every stomach-filling stoste of the 2nd, 3,4 group of mouse, 2 times it is dilute
Liquid and 4 times of dilution 0.5ml are released, control group stomach-filling the same dose of physiological saline are observed continuously one week after application, and record each
Drinking-water, the diet, death, clinical manifestation of mouse are organized, dissect is carried out within the 8h if having dead mouse after death, if without dead
It dies, randomly selects 2 for every group after experiment, dissect after cervical dislocation is lethal is observed the lesion situation of each organ and is damaged
Situation simultaneously records.
Experimental result:
1. each group mouse drinking-water, diet are all normal, indifference；
2. each group mouse does not occur death；
3. each group mouse is without poisoning clinical manifestation；
4. three groups of mouse dissects are normal, each organ is not damaged and other fouling characteristics；
The result shows that: two-arch tunnel ivermectin praziquantel emulsion good security of the invention.
3 pharmacodynamic test of test example
Somewhere morbidity warren, 3 monthly age New Zealand rabbits play expelling parasite needle since breeding environment is poor not in time after wean, then
In addition ambient humidity is big, temperature is high, causes in rabbit group that acarid disease is high-incidence, and main physical signs show as having bulk incrustation inside auricle,
Some are serious to be immediately seen from the outside even without breaking auricle into two with one's hands.Due to itching, rabbit frequently grabs ear with foot, causes to fester, pole
Easy secondary infection, and due to hypoimmunity, environmental condition is poor, and also suspecting has the mixed sense of other kinds of helminth.Choose the state of an illness
Similar rabbit 60, random point 3 groups, every group 20.First group is control group, and 1ml physiological saline is subcutaneously injected in every neck,
Second group is common ivermectin injection drug control group, and every is injected ivermectin injection by 3mg/kg, and third group is
Medicine group of the invention, two-arch tunnel emulsion of the present invention prepared by embodiment 1, with the calculating of ivermectin amount, the agent of 3mg/kg
Amount, neck subcutaneous injection.After a week, it is primary to repeat medication.After treatment, the daily performance for observing rabbit and acarid incrustation fall off
Situation, and record, it the results are shown in Table shown in 2.
Evaluation criterion:
Dead: experimental animal occurs dead during finger to finger test, and -1 point；
Invalid: after referring to medication, though experimental animal does not occur death, Symptoms and sign do not have improvement sign, and 0 point；
Lapse to: after referring to medication, experimental animal Symptoms and sign are obviously improved, and rabbit no longer acutely grabs auricle, auricle
Inside incrustation obviously becomes smaller, but does not completely disappear also, in convalescence, 1 point；
Recovery from illness: after referring to medication, experimental animal fully recovers, and all behaviors and sign indifference before the onset, in auricle
It forms a scab and completely falls off disappearance, 2 points；
Total effective rate: the ratio of the experimental animal number and this group of experimental animal sum that lapse to and fully recover after referring to medication ×
100%；
2 pharmacodynamic test result of table
。
Test result: control group does not have to any drug, and in the case where leaning on animal itself resistance completely, endoparasite is cured
Hair is serious；Common ivermectin injection group, lapses to rate 40%, cure rate 45%, total effective rate 85%, and emulsion group of the present invention lapses to
Rate 20%, cure rate 75%, total effective rate 95%, hence it is evident that be better than common ivermectin injection group.
Conclusion (of pressure testing): the treatment of compound ivermectin praziquantel two-arch tunnel emulsion of the invention to animal epizoon
With significant curative effect.
Claims (7)
1. a kind of compound ivermectin praziquantel two-arch tunnel emulsion, which is characterized in that the weight of every 100g emulsion forms are as follows: she
Tie up 0.1~2g of rhzomorph, 0.1~25g of praziquantel, 0.01~3g of Arecoline hydrobromide, 1.0~10g of solvent naphtha, cosolvent 0.1~
5g, 20~30g of emulsifier, 10~20g of assistant for emulsifying agent, surplus are deionized water；The emulsifier be Tween-81, Tween-40,
One of Tween-80 compounded with one of Arlacel-80, Arlacel-85 after mixed surfactant；The cosolvent is N,
N- dimethyl propylene alkenyl urea.
2. compound ivermectin praziquantel two-arch tunnel emulsion as described in claim 1, which is characterized in that every 100g emulsion
Weight composition are as follows: 0.5~1g of ivermectin, 5~20g of praziquantel, 1.0~2g of Arecoline hydrobromide, 3~8g of solvent naphtha, hydrotropy
2~4g of agent, 23~28g of emulsifier, 12~18g of assistant for emulsifying agent, surplus are deionized water.
3. compound ivermectin praziquantel two-arch tunnel emulsion as claimed in claim 2, which is characterized in that every 100g emulsion
Weight composition are as follows: ivermectin 1g, praziquantel 15g, Arecoline hydrobromide 1.5g, solvent naphtha 6g, cosolvent 3g, emulsifier 25g,
Assistant for emulsifying agent 15g, surplus are deionized water.
4. compound ivermectin praziquantel two-arch tunnel emulsion a method according to any one of claims 1-3, which is characterized in that described molten
Agent oil is the mixture of one or both of ethyl acetate, isopropyl myristate, injection soybean oil, ethyl oleate.
5. compound ivermectin praziquantel two-arch tunnel emulsion a method according to any one of claims 1-3, which is characterized in that described to help
Emulsifier is one or two kinds of mixtures of dehydrated alcohol, 1,2- propylene glycol, polyethylene glycol 200 or glycerine.
6. compound ivermectin praziquantel two-arch tunnel emulsion a method according to any one of claims 1-3, which is characterized in that described to go
Ionized water is sterile deionized water.
7. the preparation method of any compound ivermectin praziquantel two-arch tunnel emulsion of claim 1-3, feature exist
In, comprising the following steps: (a) first mixes ivermectin, praziquantel and solvent naphtha, sequentially adds cosolvent, emulsifier mixing
Obtain system 1；(b) Arecoline hydrobromide is dissolved in deionized water, assistant for emulsifying agent mixing is added, obtains system 2；(c) system 1 is added
Heat is to 60~80 DEG C, at this temperature, is slowly added to system 2, and stirring while adding, system is added completely by dilute retrogradation to system 2
Afterwards, continue to stir and maintain 60~80 DEG C of at least 30min of temperature, stop stirring later, standing is cooled to room temperature to obtain the final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610773785.5A CN106361758B (en) | 2016-08-31 | 2016-08-31 | A kind of compound ivermectin praziquantel two-arch tunnel emulsion and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610773785.5A CN106361758B (en) | 2016-08-31 | 2016-08-31 | A kind of compound ivermectin praziquantel two-arch tunnel emulsion and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106361758A CN106361758A (en) | 2017-02-01 |
| CN106361758B true CN106361758B (en) | 2019-02-12 |
Family
ID=57902377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610773785.5A Active CN106361758B (en) | 2016-08-31 | 2016-08-31 | A kind of compound ivermectin praziquantel two-arch tunnel emulsion and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106361758B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1568938A (en) * | 2003-07-22 | 2005-01-26 | 范敏华 | Nanometer emulsion and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6343802B2 (en) * | 2013-07-03 | 2018-06-20 | ポーラ化成工業株式会社 | Skin cleansing composition |
-
2016
- 2016-08-31 CN CN201610773785.5A patent/CN106361758B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1568938A (en) * | 2003-07-22 | 2005-01-26 | 范敏华 | Nanometer emulsion and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 关于驱虫药药效的对比试验;哈得力·阿扎太等;《当代畜牧》;20141031;第90-91页 |
| 复方伊维菌素和吡喹酮纳米乳的制备与质量评价;汤佳莘等;《西北农林科技大学学报（ 自然科学版）》;20140228;第42卷(第2期);第35-40页 |
| 微乳及微乳制剂的研究;史同瑞等;《上海畜牧兽医通讯》;20051231(第5期);第10-11页 |
| 难溶性药物给药策略的研究;何洪等;《中医临床研究》;20111231;第3卷(第2期);第17-18页 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106361758A (en) | 2017-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60019435T2 (en) | THERAPEUTIC APPLICATION OF POLYMERS CONTAINING GAMMA HYDROXYBUTYRATE | |
| Ottesen et al. | Ivermectin in human medicine | |
| CN105792829A (en) | Treatment of papulopustular rosacea with ivermectin | |
| CN103461360B (en) | The preparation method of a kind of Avermectin and griseofulvin composite pesticidal nanoemulsion | |
| EP1850830A1 (en) | Method for production of a preparation of a solid dmso-containing silicone oil emulsion for the binding of reactive oxygen compounds in human and animal bodies | |
| EP0764022B1 (en) | Agonists and antagonists of the nicotinic acetylcholine receptors of insects to control endoparasites | |
| CN101011408A (en) | Animal-used compound preparation for treating parasitic disease in or out of livestock and fowl body and preparation method thereof | |
| CN104288222B (en) | A kind of Nano medication for treating cow endometritis and preparation method thereof | |
| CN106361758B (en) | A kind of compound ivermectin praziquantel two-arch tunnel emulsion and preparation method thereof | |
| CN103830170A (en) | Ivermectin in-vivo gel injection and preparation method thereof | |
| CN102283856B (en) | Veterinary compound ivermectin liposome medicine and preparation method thereof | |
| Lunestad et al. | Veterinary drug use in aquaculture | |
| EP1103181A1 (en) | Combination of N-phenyl-N'-benzoyl urea derivatives and avermectine compounds for parasite control | |
| CN101590016A (en) | A kind of ivermectin emulsion for injection and preparation method thereof | |
| WO1995005181A2 (en) | Drug for parasitic control of animals | |
| CN107375311A (en) | Liquiritin treats the pharmaceutical applications of neurogenic pain | |
| Maravi et al. | Therapeutic management of chronic generalized demodicosis in dogs | |
| KR101650043B1 (en) | Composition for Exterminating Scutica in Fishes Containing Mebendazole | |
| CN101987108A (en) | Compound injection for repelling internal and external parasites of animal bodies and preparation method thereof | |
| CN103478144B (en) | A kind of Avermectin and griseofulvin composite pesticidal nanoemulsion | |
| CN108295119A (en) | Special pest repellant of a kind of largemouth bass cultivation and preparation method thereof | |
| DE1667891A1 (en) | New therapeutic compositions with analgesic activity | |
| CN106821975A (en) | A kind of Mo Naitaier oral liquids and its preparation method and application | |
| RU2762565C1 (en) | Medicinal product for treating parasitoses of fur-bearing animals | |
| CN103565787B (en) | A kind of pharmaceutical composition containing Furanodiene. and pharmaceutical applications thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |