CN106361468B - A kind of Bone Defect Repari system of big stage bone defect - Google Patents
A kind of Bone Defect Repari system of big stage bone defect Download PDFInfo
- Publication number
- CN106361468B CN106361468B CN201610740327.1A CN201610740327A CN106361468B CN 106361468 B CN106361468 B CN 106361468B CN 201610740327 A CN201610740327 A CN 201610740327A CN 106361468 B CN106361468 B CN 106361468B
- Authority
- CN
- China
- Prior art keywords
- bone defect
- braced frame
- bone
- big stage
- convex body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2875—Skull or cranium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30576—Special structural features of bone or joint prostheses not otherwise provided for with extending fixation tabs
- A61F2002/30578—Special structural features of bone or joint prostheses not otherwise provided for with extending fixation tabs having apertures, e.g. for receiving fixation screws
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30971—Laminates, i.e. layered products
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
Abstract
The present invention provides a kind of Bone Defect Repari system of big stage bone defect, including braced frame and bone renovating material, it is equipped with grid on the support frame, convex body is equipped in the outside of braced frame, screw hole is equipped on convex body, screw is connected in screw hole, the material of braced frame is polymerization macromolecule material or metal material, bone renovating material embeds braced frame, the main component of bone renovating material is collagen, calcium salt and growth factor, the load-bearing of braced frame, supporting role and bone renovating material promote the effect of osteanagenesis to combine, realize the bony union of big stage bone defect；Braced frame, convex body and screw are all made of the compound of polyactide copolymer or blend high molecular material and magnesium salts, or the metal material production of magnesium, magnesium base alloy, these materials human body memory over time, can be degraded automatically disappearance by human body, it avoids in long-term existence human body and generates adverse reaction, or even the danger infected occur.
Description
Technical field
The invention belongs to bone defect healing field more particularly to a kind of Bone Defect Repari systems of big stage bone defect.
Background technique
The reparation of bulk bone defect caused by congenital osteopathy, wound, infection or tumour resected bone etc. and reconstruction one
It is directly the problem and research hotspot of field of orthopaedics.Although traditional autologous bone transplanting skeletonization effect is good, bone resource is less, it is difficult to
The bone defect of larger area is repaired, and complicated for operation, allogenic bone transplantation, artificial substituent's displacement, Limb lengthening Transfer have all existed
Clinically applied, but all had some limitations, for example, due to titanium alloy web plate have good biocompatibility,
The advantages that non-toxic and high-intensitive, is widely used in the clinical application to skull reparation, but in human body due to titanium alloy
It can not be degraded, patient often has heavier sense of insecurity, especially for the patient of big stage bone defect, large area titanium alloy
Constriction can make patient cause headache, it is dizzy, be afraid of vibration and to syndromes such as the rejections of titanium alloy, overlong time may
The problems such as causing infection；And in children's skull repair process, because children's skull is in the stage of development, skull can be continuous
Growth changes, and since titanium alloy web plate will not increase, will cause children's skull asymmetry, causes to the brain development of children
It influences.
Summary of the invention
The present invention provides a kind of Bone Defect Repari system that is light, promoting osteanagenesis, degradable big stage bone defect.
In order to solve the above technical problems, the technical solution adopted by the present invention is that: a kind of Bone Defect Repari system of big stage bone defect
System, including braced frame and bone renovating material are equipped with grid in the braced frame, are equipped in the outside of the braced frame
Convex body is equipped with screw hole on the convex body, screw is connected in the screw hole, the material of the braced frame is
Polymerization macromolecule material or metal material, the bone renovating material embed the braced frame, bone renovating material and the branch
The shape of support frame frame is identical, and the main component of the bone renovating material is collagen, calcium salt and growth factor.
Further, the material of the convex body and the screw is polymerization macromolecule material or metal material.
Further, the polymerization macromolecule material is the compound of polyactide copolymer or blend and magnesium salts.
Further, the metal material is magnesium or magnesium base alloy.
Further, the shape of the braced frame can be planar as, tubulose or irregular polyhedrons.
It further, further include porous insulation film, the porous insulation film is covered on the outer surface of the bone renovating material.
Further, the porous insulation film with a thickness of 0.5mm-2mm, aperture 5um-100um.
Further, the convex body is no less than 3.
Further, the cylinder vertical with the braced frame is provided on the apex angle of the grid, the cylinder is in
Reversed acanthoid.
Further, the length of the cylinder is in 2mm-10mm, diameter 2mm-5mm.
Compared with prior art, the present invention has the advantage that is with beneficial effect: 1, utilizing braced frame and Bone Defect Repari material
Expect the Bone Defect Repari system of embedding, the load-bearing of braced frame, supporting role and bone renovating material promote the effect of osteanagenesis, and existing
The reparation of big stage bone defect is compared in technology using titanium alloy web plate, alleviate patient due to head weight and bring
Constriction reduces the convalescence of patient in conjunction with the facilitation of bone renovating material；2, braced frame, convex body and screw are adopted
With polyactide copolymer or the metal material of blend high molecular material and magnesium salts compound or magnesium, magnesium base alloy, these materials
Human body memory over time, can be degraded automatically by human body disappearances, avoid in long-term existence human body and generate it is bad instead
It answers, or even the danger infected occurs.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of the braced frame of the Bone Defect Repari system of big stage bone defect of the present invention.
Fig. 2 is a kind of decomposition texture schematic diagram of the Bone Defect Repari system of big stage bone defect of the present invention.
Fig. 3 is a kind of embedding structural schematic diagram of the Bone Defect Repari system of big stage bone defect of the present invention.
In figure: 1- braced frame；2- bone renovating material；3- grid；4- convex body；5- screw hole；6- screw；7- porous insulation
Film；8- cylinder.
Specific embodiment
It elaborates with reference to the accompanying drawing to a specific embodiment of the invention.
As shown in Figure 1, Figure 2 and Figure 3, a kind of Bone Defect Repari system of big stage bone defect, including braced frame 1 and Bone Defect Repari
Material 2 is equipped with grid 3 in the braced frame 1, convex body 4 is equipped in the outside of the braced frame 1, on the convex body 4
Equipped with screw hole 5, screw 6 is connected in the screw hole 5, the material of the braced frame 1 is polymerization macromolecule material
Material or metal material, the bone renovating material 2 embed the braced frame 1, bone renovating material 2 and the braced frame 1
Shape is identical, and the main component of the bone renovating material 2 is collagen, calcium salt and growth factor, is incited somebody to action using bone renovating material 2
Bone Defect Repari system of the structure that braced frame 1 embeds as big stage bone defect, wherein braced frame 1 is mainly used for load-bearing and branch
Support effect, can be the geometry of single-layer or multi-layer, and 1 material of braced frame is polymerization macromolecule material or metal material,
Middle polymerization macromolecule material is the compound of polyactide copolymer or blend and magnesium salts, wherein the poly- molecular weight for handing over rouge is higher than
20KDa, magnesium salts are magnesium carbonate or magnesium phosphate, and metal material is mainly magnesium or magnesium base alloy, these materials can play very well
Supporting role, and can be degraded by human body, and human body is not injured；Bone renovating material 2, which has, promotes bone again well
Raw ability, its main component are collagen, calcium salt and growth factor, and wherein collagen is I type and/or type III glue
Former albumen, calcium salt are hydroxyapatite or calcium phosphate, and growth factor is Nell-1 albumen, therefore can be used as bone renovating material
Substance has allogeneic decalcified bone matrix, bone- xenograft decalcified bone matrix etc..The convex body 4 and screw 6 can consolidate braced frame 1
It is scheduled on bone defect position, the diameter of screw 6 is between 0.5mm-5mm, and length is between 1mm-50mm, the convex body 4 and described
The material of screw 6 is polymerization macromolecule material or metal material, can degrade and disappear in human body as braced frame 1.
Further, the shape of the braced frame 1 can be planar as, tubulose or irregular polyhedrons, braced frame 1
Shape can be corresponding from the shape of different bone defects, be not limited to any shape, and bone renovating material 2 and support
The shape of frame 1 is identical, can satisfy and carries out Bone Defect Repari to the case of big stage bone defect of different shapes.
It further, further include porous insulation film 7, the porous insulation film 7 is covered on the appearance of the bone renovating material 2
Face, the porous insulation film 7 with a thickness of 0.5mm-2mm, aperture 5um-100um, the main function of porous insulation film 7 be by
Soft tissue is isolated with bone tissue, prevents from occupying the growth position of bone tissue since soft tissue growth is too fast, in addition, porous
Barrier film 7 is the wherein collagen egg by collagen or collagen and polysaccharide or collagen, polysaccharide and calcium salt Material cladding
White is I-type collagen, and polysaccharide is chitosan, and calcium salt is hydroxyapatite or calcium phosphate, and therefore, porous insulation film 7 also can quilt
Human body is degraded.
Further, the convex body 4 is no less than 3, guarantees that braced frame 1 can be good at being fixed on bone defect position.
Further, the cylinder 8 vertical with the braced frame 1, the cylinder are provided on the apex angle of the grid 3
8 be in reversed acanthoid, the length of the cylinder 8 in 2mm-10mm, diameter 2mm-5mm, when bone renovating material 2 to braced frame 1 into
When row embedding, cylinder 8 has certain reinforcement effect to bone renovating material 2.
When carrying out Bone Defect Repari to patient using this big stage Bone Defect Repari system, bone renovating material 2 and braced frame 1 are carried out
Embedding, is produced the big stage Bone Defect Repari system being consistent with patient trauma's area, is consolidated using the screw 6 on convex body 4 to it
It is fixed, porous insulation film is covered in the outer surface of bone renovating material 2, achievees the purpose that soft tissue and bone tissue is isolated, by one section
Time, under the facilitation of bone renovating material 2, the osteanagenesis of patient trauma position, wound healing, the braced frame of patient's body
1, convex body 4, screw 6 and porous insulation film 8 can decompose disappearance in human body, and will not cause harm to the human body.
One embodiment of the present invention has been described in detail above, but the content is only preferable implementation of the invention
Example, should not be considered as limiting the scope of the invention.It is all according to all the changes and improvements made by the present patent application range
Deng should still be within the scope of the patent of the present invention.
Claims (9)
1. a kind of Bone Defect Repari system of big stage bone defect, it is characterised in that: including braced frame (1) and bone renovating material (2),
Grid (3) are equipped on the braced frame (1), convex body (4) are equipped in the outside of the braced frame (1), in the convex body
(4) screw hole (5) are equipped with, screw (6) are connected in the screw hole (5), the material of the braced frame is poly-
High molecular material or metal material, the bone renovating material is closed to embed the braced frame, the bone renovating material with it is described
The shape of braced frame is identical, and the main component of the bone renovating material is collagen, calcium salt and growth factor；
It is provided on the apex angle of the grid (3) cylinder vertical with the braced frame (1) (8), the cylinder (8) is in
Thorn-like.
2. a kind of Bone Defect Repari system of big stage bone defect according to claim 1, it is characterised in that: the convex body (4)
Material with the screw (6) is polymerization macromolecule material or metal material.
3. a kind of Bone Defect Repari system of big stage bone defect according to claim 1 or 2, it is characterised in that: the polymerization
High molecular material is the compound of polyactide copolymer or blend and magnesium salts.
4. a kind of Bone Defect Repari system of big stage bone defect according to claim 1 or 2, it is characterised in that: the metal
Material is magnesium or magnesium base alloy.
5. a kind of Bone Defect Repari system of big stage bone defect according to claim 1, it is characterised in that: the braced frame
(1) shape is curved, tubulose or irregular polyhedrons.
6. a kind of Bone Defect Repari system of big stage bone defect according to claim 1, it is characterised in that: further include porous resistance
Diaphragm (7), the porous insulation film (7) are covered on the outer surface of the bone renovating material (2).
7. a kind of Bone Defect Repari system of big stage bone defect according to claim 6, it is characterised in that: the porous insulation
Film (7) with a thickness of 0.3mm-2mm, aperture 5um-100um.
8. a kind of Bone Defect Repari system of big stage bone defect according to claim 1, it is characterised in that: the convex body (4)
No less than 3.
9. a kind of Bone Defect Repari system of big stage bone defect according to claim 8, it is characterised in that: the cylinder (8)
Length in 2mm-10mm, diameter 2mm-5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610740327.1A CN106361468B (en) | 2016-08-26 | 2016-08-26 | A kind of Bone Defect Repari system of big stage bone defect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610740327.1A CN106361468B (en) | 2016-08-26 | 2016-08-26 | A kind of Bone Defect Repari system of big stage bone defect |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106361468A CN106361468A (en) | 2017-02-01 |
| CN106361468B true CN106361468B (en) | 2019-01-15 |
Family
ID=57903398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610740327.1A Active CN106361468B (en) | 2016-08-26 | 2016-08-26 | A kind of Bone Defect Repari system of big stage bone defect |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106361468B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022508798A (en) * | 2018-10-16 | 2022-01-19 | オスディーサイン アーベー | Implants to fill boreholes in bone and methods to fill boreholes in bone |
| CN115154654A (en) * | 2022-06-28 | 2022-10-11 | 广东健齿生物科技有限公司 | Oral bone tissue repair system |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101474430A (en) * | 2009-01-13 | 2009-07-08 | 武汉大学 | Tissue regeneration membrane with bioactivity and preparation method thereof |
| US20120310365A1 (en) * | 2011-05-30 | 2012-12-06 | 3Dceram | Reinforced biocompatible ceramic implant and manufacturing method thereof |
| CN103857351A (en) * | 2011-08-22 | 2014-06-11 | 奥斯设计公司 | Implants and methods of using the implants to fill holes in bone tissue |
| WO2016024248A1 (en) * | 2014-08-14 | 2016-02-18 | Ossdsign Ab | Bone implants for correcting bone defects |
| CN206214171U (en) * | 2016-08-26 | 2017-06-06 | 天津市赛宁生物工程技术有限公司 | A kind of Bone Defect Repari device |
-
2016
- 2016-08-26 CN CN201610740327.1A patent/CN106361468B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101474430A (en) * | 2009-01-13 | 2009-07-08 | 武汉大学 | Tissue regeneration membrane with bioactivity and preparation method thereof |
| US20120310365A1 (en) * | 2011-05-30 | 2012-12-06 | 3Dceram | Reinforced biocompatible ceramic implant and manufacturing method thereof |
| CN103857351A (en) * | 2011-08-22 | 2014-06-11 | 奥斯设计公司 | Implants and methods of using the implants to fill holes in bone tissue |
| WO2016024248A1 (en) * | 2014-08-14 | 2016-02-18 | Ossdsign Ab | Bone implants for correcting bone defects |
| CN206214171U (en) * | 2016-08-26 | 2017-06-06 | 天津市赛宁生物工程技术有限公司 | A kind of Bone Defect Repari device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106361468A (en) | 2017-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Bendtsen et al. | Development of a novel alginate‐polyvinyl alcohol‐hydroxyapatite hydrogel for 3D bioprinting bone tissue engineered scaffolds | |
| CN106236326B (en) | Big stage Bone Defect Repari system | |
| Lee et al. | The effect of bacterial cellulose membrane compared with collagen membrane on guided bone regeneration | |
| JP5527760B2 (en) | Collagen / hydroxyapatite composite skeleton and method for producing the same | |
| EP1275405B1 (en) | Implant with porous protein matrix and process for its production | |
| JP5930476B2 (en) | Production of regenerative tissue scaffolds | |
| CN101020082B (en) | Bone repairing material and its prepn process and use | |
| TWI436779B (en) | Biodegradable filler for restoration of alveolar bones | |
| CN107050519B (en) | Preparation method of multilayer absorbable biological membrane | |
| CN104971380A (en) | Acellular matrix repairing gel and new method for preparing the same | |
| CN102188754B (en) | Nanometer pore hydroxyl calcium phosphate/aquogel materials | |
| CN102380129B (en) | Sodium hyaluronate and KGM porous bracket material and method for preparing same | |
| CN106361468B (en) | A kind of Bone Defect Repari system of big stage bone defect | |
| JP5879459B2 (en) | Dehydrated partially purified bone replacement material containing hydrophilic phosphate groups | |
| CN114504677B (en) | 3D printing skull repairing titanium mesh and preparation method thereof | |
| ITMI20092073A1 (en) | COMPOSITE BIO-MIMETIC MATERIALS, RELATED PREPARATION PROCESS AND THEIR USE FOR THE IMPLEMENTATION OF MONO-, BI- OR MULTI-LAYER STRUCTURES FOR THE REGENERATION OF BONE, CARTILAGE OR OSTEOCARTILAGE | |
| Yu et al. | Mineralized collagen/Mg–Ca alloy combined scaffolds with improved biocompatibility for enhanced bone response following tooth extraction | |
| CN106860917B (en) | Individualized 3D who contains mosaic structure prints bone tissue engineering support | |
| CN106730011A (en) | A kind of xenogenesis acellular nerve graft thing with prevention tissue adhesion function and preparation method thereof | |
| CN114452441A (en) | Skull repairing polyether-ether-ketone material and preparation method thereof | |
| CN105536047A (en) | Skull repair material and preparation method for same | |
| CN206214171U (en) | A kind of Bone Defect Repari device | |
| CN206214236U (en) | A kind of megastage Bone Defect Repari device | |
| CN208864880U (en) | A kind of assembly type cellular bone tissue engineering scaffold | |
| CN108744065A (en) | A kind of tissue recovery support and its preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |