CN106348545A - Integrated treatment process for clindamycin hydrochloride production wastewater - Google Patents
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F9/00—Multistage treatment of water, waste water or sewage
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- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/02—Treatment of water, waste water, or sewage by heating
- C02F1/04—Treatment of water, waste water, or sewage by heating by distillation or evaporation
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/02—Treatment of water, waste water, or sewage by heating
- C02F1/04—Treatment of water, waste water, or sewage by heating by distillation or evaporation
- C02F1/048—Purification of waste water by evaporation
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- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
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- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/38—Treatment of water, waste water, or sewage by centrifugal separation
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- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
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- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/72—Treatment of water, waste water, or sewage by oxidation
- C02F1/722—Oxidation by peroxides
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- C02F2103/00—Nature of the water, waste water, sewage or sludge to be treated
- C02F2103/34—Nature of the water, waste water, sewage or sludge to be treated from industrial activities not provided for in groups C02F2103/12 - C02F2103/32
- C02F2103/343—Nature of the water, waste water, sewage or sludge to be treated from industrial activities not provided for in groups C02F2103/12 - C02F2103/32 from the pharmaceutical industry, e.g. containing antibiotics
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2305/00—Use of specific compounds during water treatment
- C02F2305/02—Specific form of oxidant
- C02F2305/026—Fenton's reagent
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- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
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- C02F3/28—Anaerobic digestion processes
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- C02F3/30—Aerobic and anaerobic processes
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Abstract
The invention discloses an integrated treatment process for clindamycin hydrochloride production wastewater. The process comprises the following steps: performing triple-effect evaporation and concentration on the clindamycin hydrochloride production wastewater, performing centrifugal separation, feeding coarse salts produced by centrifugal separation into a salt refining workshop, collecting the mother solution to be used for extracting phosphate, and repeatedly performing dissolution, evaporation and centrifugal separation on the coarse salts in the salt refining workshop, thereby obtaining high-purity chlorine salts; washing by ethanol, thereby obtaining the finished chlorine salts; collecting the produced mother solution to be used for extracting phosphate; performing evaporation and concentration on the phosphate mother solution, centrifuging and washing, thereby obtaining the phosphate; rectifying the scrubbing solution, recycling the methanol, feeding the distillation residues into a hazardous waste treatment center, merging the foul condensate produced by multiple-effect evaporation and crystallization mother liquor produced by centrifugal separation, homogenizing, and performing anaerobic and aerobic biological treatment and advanced treatment. The method provided by the invention is an integrated method for combining multiple-effect evaporation, methanol rectification and biological treatment and has the characteristics of reasonable resource utilization, low cost, simplicity and convenience in operation, stable operation and the like.
Description
Technical field
The invention belongs to technical field of waste water processing is and in particular to a kind of Clindamycin Hydrochloride produces the integrated process of waste water
Technique.
Background technology
Also known as clindamycin, this production waste water is mainly included in its building-up process Clindamycin Hydrochloride (clindamycin)
The mother solution of formation, equipment flushing water etc., mainly contain the part material in production process and intermediate product, such as glycerol, acetone, second
Alcohol, ammonia, phosphorus oxychloride, dichloroethanes, pyridine, dmf, tetracycline, lincomycin and residual fraction Clindamycin Hydrochloride, Organic substance
Content is very high, and cod is up to 70000～80000mg/l, and salinity is up to 15%, belongs to the organic work of high concentration of typical difficult degradation
Industry waste water.
From research data both domestic and external, the processing method of antibiotic waste water includes: physico-chemical process, biochemical process and multiple
The group technology of method, various methods have advantage and the deficiency of its own.The physical chemistry method master processing for antibiotic waste water
Have: precipitation, burning, membrance separation, light degradation and electrolysis etc. although materilization freatment method is respectively provided with certain treatment effect,
But some needs add a large amount of chemical agents so that processing cost improve, complex operation；The a large amount of by-product of some generations, place
Reason is improper to easily cause secondary pollution, therefore all limits their application to a certain extent.Biological treatment mainly has aerobic
Biological treatment, anaerobic bio-treated and anaerobic-aerobic combined treatment process.Biological treatment clearance is higher, and operating cost is low, surely
Fixed, but because synthesis class antibiotic industrial waste water is high salt, high concentrated organic wastewater, directly biological treatment need to be entered to former waste liquid
Ten times of row or even the dilution of Radix Achyranthis Bidentatae, clear water, power consumption are very big, lead to operating cost very high, can not meet increasingly strict place
Reason requires.
Content of the invention
For problems of the prior art, the present invention provides a kind of Clindamycin Hydrochloride to produce the integrated process of waste water
Technique, is capable of efficient process Clindamycin Hydrochloride waste water, while ensureing efficient clearance, makes waste water in processing procedure
The utilization of waste as resource of middle generation, final discharged wastewater met the national standard.
For solving above-mentioned technical problem, the present invention employs the following technical solutions:
A kind of Clindamycin Hydrochloride produces the integrated treatment process of waste water, and step is as follows:
(1) Clindamycin Hydrochloride produces waste water using the concentrated mother liquor obtaining after three-effect evaporation and condensation and foul condensate, wherein dense
Contracting mother solution centrifugation, salt refining workshop sent into by the crude salt that centrifugation is produced, and the mother solution that centrifugation produces collects
For extracting phosphate；
(2) in salt refining workshop, crude salt repeatedly dissolved, evaporates, centrifugation, obtaining high-purity villaumite, after methanol washing
Obtain finished product villaumite (nacl), the mother solution of generation collects for extracting phosphate, and cleaning mixture rectification is reclaimed methanol loop and made
With；
(3) mother solution producing step (1) and step (2) is evaporated concentrating, and obtains crystalline mother solution and phosphoric acid after centrifugation
Salt, phosphate obtains finished product phosphate (na after methanol washing3po4), cleaning mixture rectification is reclaimed methanol loop and is used, and still residue send
To useless processing center of endangering；
(4) foul condensate that described step (1) triple effect evaporation produces and the crystalline mother solution of step (3) centrifugation generation merge all
Carry out anaerobic bio-treated, Aerobic biological process and advanced treating successively after matter.
Crude salt in described step (2) needs to carry out 2～3 re-dissolved, evaporation, centrifugations, obtains after methanol washing
Obtain finished product villaumite.
In described step (2), crude salt is in subtractive process, controls steam pressure 0.18～0.22mpa, 70～80 DEG C of temperature,
When density reaches 1.38～1.40, it is centrifuged.
The mother solution in described step (3) producing step (1) and step (2) is evaporated concentrating, is centrifuged acquisition phosphate
The same step of method (2) in crude salt process for purification.
Clindamycin Hydrochloride waste water after described step (4) desalination adopts abr anaerobic treatment, and the time of staying is little for 16 ~ 24
When.
Waste water after anaerobic treatment for the described step (4) carries out a/o biological treatment, and the time of staying is 96 ~ 120 hours,
Wherein a pool volume is the 30% ~ 40% of o pool volume.
Advanced treating in described step (4) aoxidizes for fenton, and the dosage of every liter of water is h2o20.6ml～1.2ml,
feso4·7h2O is 0.6g～1.5g.
The concrete principle that the Clindamycin Hydrochloride of the present invention produces the integrated treatment process of waste water is as follows:
For Clindamycin Hydrochloride waste water, using triple effect evaporation processing method, due to heat energy has been used repeatedly, significantly drop
Low grade fever energy input decreases expense cost it is not necessary to add reagent.
After crude product salt is completely dissolved, controls steam pressure 0.18～0.22mpa, 70～80 DEG C of temperature in the kettle, start dense
Contracting, concentrates the later stage, every 30min detection density, when density p=1.38～1.40, starts centrifugation, obtains low-purity chlorine
Salt；After low-purity villaumite is completely dissolved, controls steam pressure 0.18～0.22mpa, 70～80 DEG C of temperature in the kettle, start dense
Contracting, concentrates the later stage, every 30min detection density, when density p=1.38～1.40, starts centrifugation, obtains high-purity chloro
Salt.Phosphate mother solution is processed using same step, can obtain low-purity phosphate.
The solid salt obtaining through evaporation, centrifugation, need to obtain dry through methanol washing to remove the Organic substance adhering to thereon
Net finished product salt, using methanol washing kettle during methanol washing, once extracts 1000l methanol and enters in washing kettle, open stirring, side
Stirring side is added thereto to 1000kg solid salt, after stirring 1 hour, centrifugation, and obtain finished product salt, this desalting refinement mistake after being dried
Journey, the purity of sodium phosphate can reach 60% ~ 70%, nacl and can reach 99.5%, finally can achieve salt resource reutilization, and rectification is washed
Liquid reclaims methanol, controls 65～70 DEG C of temperature, starts to concentrate methanol, concentrates the later stage, every 30min detectable concentration, when concentration≤
When 5%, steam off valve, stop concentrating, still residue is transported to the useless processing center of danger after collecting.
The crystalline mother solution of the foul condensate of multiple-effect evaporation generation and centrifugation generation carries out aerobic-anaerobic after merging homogenizing
Biological treatment, this biologic treating technique is abr anaerobism, a/o is aerobic, finally carries out advanced treating, using fenton oxidation technology.
For above-mentioned bioremediation, the special structure of abr reactor, is complete with respect to the fluidised form in single lattice region
Mixed flow, is plug-flow for whole reactor again, and this special hydraulics are so that system has good impact resistance energy
Power so as to have stable treatment effect, due to upward flow relatively under to the sectional area of stream little, thus the speed in upward flow
Fast, so that anaerobic sludge effectively and rapidly can be contacted with sewage, pollutant can be accelerated to contact with antibacterial, carry
The high capacity utilization of system, accordingly can greatly reduce reaction dead zone, during operation, the dead band of abr system can control
Less than 37%, but the dead band of common anaerobic filter up to 50% ~ 93%；And this special fluidised form is more conducive to anaerobic grain sludge
Formation, through abr section, its hydraulic detention time be 16～24h when, the clearance of cod can reach 90%～92%.
After abr anaerobic bio-treated, waste water carries out a/o Aerobic Process for Treatment again.A/o technique will be good to leading portion anoxia section and back segment
Oxygen section is cascaded, and a section do is not more than 0.2mg/l, o section do=2～4mg/l.In anoxia section heterotrophic bacteria by the shallow lake in sewage
The suspended contaminant such as powder, fiber, carbohydrate and dissolved organic matter are hydrolyzed to organic acid, so that larger molecular organicses is decomposed into
Small organic molecule, insoluble Organic substance changes into dissolved organic matter, when these products entrance through anaerobic hydrolysis are aerobic
When pond carries out Aerobic Process for Treatment, the biodegradability of sewage and the utilization ratio of oxygen can be improved；Heterotrophic bacteria will be organic to protein, fat etc.
Thing carries out ammonification (n in organic chain or the amino in aminoacid) and dissociates ammonia (nh3、nh4 +), under sufficient oxygen supply condition, from
The Nitrification of bacteria is by nh3- n(nh4 +) it is oxidized to no3 -, a pond, under anoxic conditions, heterotrophic bacteria are back to by backflow control
Denitrification by no3 -It is reduced to molecular nitrogen (n2) complete c, n, o circulation in ecology, realize the innoxious place of sewage
Reason.This technology has that efficiency high, flow process be simple, anoxic denitrification process has higher degradation efficiency to pollutant and anoxia/
The features such as resistance to overload shock ability of aerobic process is strong.
A/o reactor residence time is 96 ~ 120 hours, and a pool volume is the 30% ~ 40% of o pool volume.Cod volumetric loading=1
~1.25kgcod/(m3.d), through a/o Aerobic Process for Treatment cod clearance up to 94% ~ 96%.
Again through fenton oxidation processes, fenton oxidation processes principle is h to waste water after above-mentioned a/o Aerobic Process for Treatment2o2?
fe2+Catalytic action under decompose and produce oh, its oxidizing potential reaches 2.8v, and it passes through the approach such as electron transfer by Organic substance oxygen
Change and resolve into small molecule inorganic matters.Meanwhile, fe2+It is oxidized to fe3+Produce coagulating sedimentation, remove suspended organic matter.Fenton tries
Agent has oxidation and two kinds of effects of coagulation in water process.
Beneficial effects of the present invention: this integrated treatment process adopts triple effect evaporation to remove according to the feature of chemosynthesis pharmacy
A large amount of salinities in waste water, make the salinity in waste water meet the needs of biological treatment.After the salt of removing is washed with methanol, resource
Comprehensive utilization, reduces the amount of landfill of solid waste, adopts anaerobic-aerobic treatment technology through the waste water of above-mentioned pretreatment, removes
Most of Organic substance, the waste water after biological treatment finally carries out fenton oxidation, and the method that the present invention provides is multiple-effect evaporation, first
Alcohol rectification and a kind of integrated approach of biological treatment combination, it has resource rational utilization, low cost, easy and simple to handle, operation
The features such as stablize, the removal of the pollutant such as cod, tp, tn, up to more than 96%, meets scientific development concepts.
Brief description
Fig. 1 is the process chart of the specific embodiment of the invention.
Specific embodiment
With reference to specific embodiment, the present invention will be further described.It should be understood that following examples are merely to illustrate this
Invention can make one according to the content of foregoing invention not for limiting the scope of the present invention, the person skilled in the art in this field
Nonessential improvement and adjustment a bit.
The integrated treatment process that a kind of Clindamycin Hydrochloride of the present invention is produced waste water is applied to certain pharmacy corporation, obtains
Preferable effect.
This Clindamycin Hydrochloride waste water takes from Henan enterprise Clindamycin Hydrochloride workshop.This enterprise's hydrochloric acid crin is mould
Element production technology be with lincomycin hydrochloride as raw material, add with chloro agent and, make chloro substituted hydroxy group, through alkalize, water
Solution, extract, become salt, concentrations, prepared after crystallization.Its technique waste water water-quality constituents is complicated, and organic concentration is high, difficult degradation and having
Harmful toxic matter is many, and waste water is in goldenrod and has intense stimulus abnormal smells from the patient, belongs to the larger high-concentration organic industrial waste water of intractability.
Embodiment 1
For the water quality characteristicses of Clindamycin Hydrochloride waste water, apply the integrated processing method of the present invention, each process can be reached single
First stable operation, standard water discharge discharge, the process target of economical and efficient, concrete process method step is as follows:
(1) the production waste water of Clindamycin Hydrochloride and other cleaning waste water mixed collections be directly by being pumped to sewage disposal system,
Sewage is first carried out three-effect evaporation and condensation by this sewage disposal system, and centrifugation goes out saliferous Organic substance again；
(2), in salt refining workshop, after crude product salt is completely dissolved, control steam pressure 0.18～0.22mpa, temperature in the kettle 70～
80 DEG C, start to concentrate, concentrate the later stage, every 30min detection density, when density p=1.38～1.40, start centrifugation, obtain
Obtain low-purity villaumite；After low-purity villaumite is completely dissolved, control steam pressure 0.18～0.22mpa, temperature in the kettle 70～80
DEG C, start to concentrate, concentrate the later stage, every 30min detection density, when density p=1.38～1.40, centrifugation, obtain high-purity
Degree villaumite；Because when temperature rising is evaporated, na3po4Dissolubility can significantly raise, although therefore solvent reduce
It is can't to separate out crystallization immediately, and the solubility with temperature of nacl liter High variation is inconspicuous, therefore solvent reduces, can be preferential
Separate out the crystalline solid of nacl, by this method, nacl can be purified, separate in salt-mixture, the purity of nacl can
Reach 99.5%；
(3) phosphate mother solution is processed using same step, can obtain low-purity phosphate, obtains through evaporation, centrifugation
The solid salt obtaining, need to obtain clean finished product salt na through methanol washing to remove the Organic substance adhering to thereon3po4, na3po4's
Purity is up to 60%～70%；Nacl can be used for the preparation of lincomycin, na again3po4Can be used for the fertilising in phosphorus deficiency soil；
(4) triple effect evaporation produces foul condensate and the crystalline mother solution that centrifugation produces finally carry out aerobic detesting after merging homogenizing
Oxygen is carried out a biological disposal upon, and this biologic treating technique is abr anaerobism, a/o is aerobic and fenton oxidation processes；The time of staying of abr section is
The clearance of 16h, cod can reach 90% removal to 5000mg/l；The time of staying of a/o Aerobic Process for Treatment is 96h, and wherein a pond holds
Long-pending 30%, the cod clearance being o pool volume, up to 94%, can remove to 300mg/l；Fenton aoxidizes cod clearance up to 60%,
Wherein every liter water need to add h2o2For 0.6ml, feso4·7h2O is 1.5g, and cod can remove to 120mg/l.
Embodiment 2
Concrete process method step is as follows:
(1) the production waste water of Clindamycin Hydrochloride and other cleaning waste water mixed collections be directly by being pumped to sewage disposal system,
Sewage is first carried out three-effect evaporation and condensation by this sewage disposal system, and centrifugation goes out saliferous Organic substance again；
(2), in salt refining workshop, after crude product salt is completely dissolved, control steam pressure 0.18～0.22mpa, temperature in the kettle 70～
80 DEG C, start to concentrate, concentrate the later stage, every 30min detection density, when density p=1.38～1.40, start centrifugation, obtain
Obtain low-purity villaumite；After low-purity villaumite is completely dissolved, control steam pressure 0.18～0.22mpa, temperature in the kettle 70～80
DEG C, start to concentrate, concentrate the later stage, every 30min detection density, when density p=1.38～1.40, centrifugation, obtain high-purity
Degree villaumite；Because when temperature rising is evaporated, na3po4Dissolubility can significantly raise, although therefore solvent reduce
It is can't to separate out crystallization immediately, and the solubility with temperature of nacl liter High variation is inconspicuous, therefore solvent reduces, can be preferential
Separate out the crystalline solid of nacl, by this method, nacl can be purified, separate in salt-mixture, the purity of nacl can
Reach 99.5%；
(3) phosphate mother solution is processed using same step, can obtain low-purity phosphate, obtains through evaporation, centrifugation
The solid salt obtaining, need to obtain clean finished product salt na through methanol washing to remove the Organic substance adhering to thereon3po4, na3po4's
Purity is up to 60%～70%；Nacl can be used for the preparation of lincomycin, na again3po4Can be used for the fertilising in phosphorus deficiency soil；
(4) triple effect evaporation produces foul condensate and the crystalline mother solution that centrifugation produces finally carry out aerobic detesting after merging homogenizing
Oxygen is carried out a biological disposal upon, and this biologic treating technique is abr anaerobism, a/o is aerobic and fenton oxidation processes；The time of staying of abr section is
The clearance of 20h, cod can reach 91% removal to 4500mg/l；The time of staying of a/o Aerobic Process for Treatment is 112h, and wherein a pond holds
Long-pending 35%, the cod clearance being o pool volume, up to 95%, can remove to 225mg/l；Fenton aoxidizes cod clearance up to 62%,
Wherein every liter water need to add h2o2For 0.8ml, feso4·7h2O is 1.3g, and cod can remove to 85.5mg/l.
Embodiment 3
Concrete process method step is as follows:
(1) the production waste water of Clindamycin Hydrochloride and other cleaning waste water mixed collections be directly by being pumped to sewage disposal system,
Sewage is first carried out three-effect evaporation and condensation by this sewage disposal system, and centrifugation goes out saliferous Organic substance again；
(2), in salt refining workshop, after crude product salt is completely dissolved, control steam pressure 0.18～0.22mpa, temperature in the kettle 70～
80 DEG C, start to concentrate, concentrate the later stage, every 30min detection density, when density p=1.38～1.40, start centrifugation, obtain
Obtain low-purity villaumite；After low-purity villaumite is completely dissolved, control steam pressure 0.18～0.22mpa, temperature in the kettle 70～80
DEG C, start to concentrate, concentrate the later stage, every 30min detection density, when density p=1.38～1.40, centrifugation, obtain high-purity
Degree villaumite；Because when temperature rising is evaporated, na3po4Dissolubility can significantly raise, although therefore solvent reduce
It is can't to separate out crystallization immediately, and the solubility with temperature of nacl liter High variation is inconspicuous, therefore solvent reduces, can be preferential
Separate out the crystalline solid of nacl, by this method, nacl can be purified, separate in salt-mixture, the purity of nacl can
Reach 99.5%；
(3) phosphate mother solution is processed using same step, can obtain low-purity phosphate, obtains through evaporation, centrifugation
The solid salt obtaining, need to obtain clean finished product salt na through methanol washing to remove the Organic substance adhering to thereon3po4, na3po4's
Purity is up to 60%～70%；Nacl can be used for the preparation of lincomycin, na again3po4Can be used for the fertilising in phosphorus deficiency soil；
(4) triple effect evaporation produces foul condensate and the crystalline mother solution that centrifugation produces finally carry out aerobic detesting after merging homogenizing
Oxygen is carried out a biological disposal upon, and this biologic treating technique is abr anaerobism, a/o is aerobic and fenton oxidation processes；The time of staying of abr section is
The clearance of 24h, cod can reach 92% removal to 4000mg/l；The time of staying of a/o Aerobic Process for Treatment is 120h, and wherein a pond holds
Long-pending 40%, the cod clearance being o pool volume, up to 96%, can remove to 160mg/l；Fenton aoxidizes cod clearance up to 65%,
Wherein every liter water need to add h2o2For 1.2ml, feso4·7h2O is 0.6g, and cod can remove to 56mg/l.
The following is the long-term detection data of enterprise:
After pretreatment, enter biochemical system index:
Final cod, bod, tp, tn, ss clearance of this method of wastewater treatment can reach more than 96%.
Above work process and result show, the set of each physical chemistry method that the present invention adopts, and can cross and give full play to respectively
The advantage of individual processing unit, reduces operating cost while ensureing efficient degradation rate to greatest extent, is processing hydrochloric acid gram
Woods mycin waste water aspect has certain advantage.
It should be pointed out that the above specific embodiments can make those skilled in the art be more fully appreciated by this
Bright creation, but limit the invention never in any form.Although above-mentioned elaborate to the present invention, not limited to this,
Those skilled in the art can modify according to the principle of the present invention, and therefore, all principles according to the present invention are carried out
Various modifications all should be understood to fall into protection scope of the present invention.
Claims (7)
1. a kind of Clindamycin Hydrochloride produces the integrated treatment process of waste water it is characterised in that step is as follows:
(1) Clindamycin Hydrochloride produces waste water using the concentrated mother liquor obtaining after three-effect evaporation and condensation and foul condensate, wherein dense
Contracting mother solution centrifugation, salt refining workshop sent into by the crude salt that centrifugation is produced, and the mother solution that centrifugation produces collects
For extracting phosphate；
(2) in salt refining workshop, crude salt repeatedly dissolved, evaporates, centrifugation, obtaining high-purity villaumite, after methanol washing
Obtain finished product villaumite, the mother solution of generation collects for extracting phosphate, and cleaning mixture rectification is reclaimed methanol loop and used；
(3) mother solution producing step (1) and step (2) is evaporated concentrating, and obtains crystalline mother solution and phosphoric acid after centrifugation
Salt, phosphate obtains finished product phosphate after methanol washing, and cleaning mixture rectification is reclaimed methanol loop and used, and still residue delivers to the useless place of danger
Reason center；
(4) foul condensate that described step (1) triple effect evaporation produces and the crystalline mother solution of step (3) centrifugation generation merge all
Carry out anaerobic bio-treated, Aerobic biological process and advanced treating successively after matter.
2. Clindamycin Hydrochloride according to claim 1 produce waste water integrated treatment process it is characterised in that: described step
Suddenly the crude salt in (2) needs to carry out 2～3 re-dissolved, evaporation, centrifugations, obtains finished product villaumite after methanol washing.
3. Clindamycin Hydrochloride according to claim 1 produce waste water integrated treatment process it is characterised in that: described step
Suddenly in (2), crude salt, in subtractive process, controls steam pressure 0.18～0.22mpa, 70～80 DEG C of temperature, and density reaches 1.38～
When 1.40, it is centrifuged.
4. Clindamycin Hydrochloride according to claim 1 produce waste water integrated treatment process it is characterised in that: described step
Suddenly the mother solution in (3) producing step (1) and step (2) is evaporated concentrating, is centrifuged the acquisition same step of phosphatic method (2)
The process for purification of middle crude salt.
5. Clindamycin Hydrochloride according to claim 1 produce waste water integrated treatment process it is characterised in that: described step
Suddenly the Clindamycin Hydrochloride waste water after (4) desalination adopts abr anaerobic treatment, and the time of staying is 16 ~ 24 hours.
6. Clindamycin Hydrochloride according to claim 1 produce waste water integrated treatment process it is characterised in that: described step
Suddenly (4) waste water after anaerobic treatment carries out a/o biological treatment, and the time of staying is 96 ~ 120 hours, and wherein a pool volume is o
The 30% ~ 40% of pool volume.
7. Clindamycin Hydrochloride according to claim 1 produce waste water integrated treatment process it is characterised in that: described step
Suddenly the advanced treating in (4) aoxidizes for fenton, and the dosage of every liter of water is h2o20.6ml～1.2ml, feso4·7h2O is
0.6g～1.5g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610978603.8A CN106348545B (en) | 2016-11-08 | 2016-11-08 | A kind of integrated treatment process of Clindamycin Hydrochloride production waste water |
Applications Claiming Priority (1)
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| CN108059308A (en) * | 2017-12-28 | 2018-05-22 | 郑州大学 | A kind of clindamycin wastewater preprocessing process |
| CN109231664A (en) * | 2018-09-19 | 2019-01-18 | 河南慧锦药业有限公司 | A kind of comprehensive processing technique of high salinity and high COD pharmacy waste water |
| CN110066077A (en) * | 2019-06-11 | 2019-07-30 | 泉州南京大学环保产业研究院 | A kind of processing method of cymoxanil agricultural chemicals waste water |
| CN111875138A (en) * | 2020-07-22 | 2020-11-03 | 关向辉 | System and method for treating wastewater containing pyridine and derivatives thereof |
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