CN106334040A - Medicinal composition for treating wind-heat type common cold, preparation method thereof and preparation - Google Patents

Medicinal composition for treating wind-heat type common cold, preparation method thereof and preparation Download PDF

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Publication number
CN106334040A
CN106334040A CN201610795111.5A CN201610795111A CN106334040A CN 106334040 A CN106334040 A CN 106334040A CN 201610795111 A CN201610795111 A CN 201610795111A CN 106334040 A CN106334040 A CN 106334040A
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preparation
parts
root
pharmaceutical composition
weight
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赵冬生
方从彬
方存杰
孙明哲
孙延标
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Anhui Runsheng Pharmaceutical Ltd By Share Ltd
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Anhui Runsheng Pharmaceutical Ltd By Share Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/346Platycodon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488Pueraria (kudzu)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535Perilla (beefsteak plant)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634Forsythia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
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  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a medicinal composition for treating wind-heat type common cold, a preparation method thereof and a preparation. The medicinal composition is prepared from the following raw materials in parts by weight: 5 to 12 parts of juncus roemerianus, 1 to 5 parts of the root of kudzu vine, 2 to 6 parts of astragalus membranaceus, 3 to 10 parts of holy basil, 1 to 5 parts of black cohosh, 5 to 12 parts of fructus forsythia, 3 to 10 parts of platycodon grandiflorum, 0.3 to 2 parts of panax notoginseng, 5 to 12 parts of folia perillae acutae and 5 to 12 parts of artemisia apiacea. The raw materials supplement each other to have a significant curative effect of treating the wind-heat type common cold; furthermore, side effects are avoided and the price is low.

Description

The pharmaceutical composition for the treatment of anemopyretic cold, its preparation method and preparation
Technical field
The present invention relates to treatment anemopyretic cold field, more particularly, to a kind of pharmaceutical composition treating anemopyretic cold, its system Preparation Method and preparation.
Background technology
Anemopyretic cold is caused by heresy criminal's table of wind-heat, lung qi are become estranged.Symptoms are heating weight, micro- foul wind, distending pain in the head, have Sweat, red swelling and pain of throat, cough, phlegm stick or yellow, the yellow tears of nasal obstruction, thirst and liking drink, the tip of the tongue side are red, the thin micro- in vain Huang of tongue.Anemopyretic cold It is more common in summer and autumn, caused by affection of exogenous wind-heat.The traditional Chinese medical science thinks, the table caused by anemopyretic cold is the heresy experiencing wind-heat is demonstrate,proved.Treatment wind-heat Flu medicine used be mostly chemicals and antibiotic although curative effect is fast, but toxic and side effect is big, long-term taking body is easy Produce drug resistance.
Content of the invention
In view of this, it is an object of the invention to provide a kind of pharmaceutical composition treating anemopyretic cold, its preparation method and Preparation, solves the big technical problem of current poisonous side effect of medicine.
To achieve these goals, the following technical scheme of present invention offer:
A kind of pharmaceutical composition treating anemopyretic cold, including the raw material of following parts by weight:
Preferably, including the raw material of following parts by weight:
Present invention also offers the preparation method of the pharmaceutical composition of above-mentioned treatment anemopyretic cold, comprise the following steps:
A) take black cohosh root, perilla leaf, pseudo-ginseng, sweet wormwood and holy basil to be immersed in water, decoct, filter, obtaining a mixture Matter;
B) take rush, the root of kudzu vine, the Radix Astragali, balloonflower root and the capsule of weeping forsythia to put in water and carry out decocting, filter, obtain b compounding substances;
C) after a compounding substances, b compounding substances being mixed, concentrate, be dried, pulverize, that is, obtain pharmaceutical composition.
Preferably, decocting time described in step a) is 2~4h;Decocting time described in step b) is 6~8h.
Present invention also offers a kind of preparation, by the pharmaceutical composition of above-mentioned treatment anemopyretic cold and pharmaceutically acceptable Auxiliary material is made.
Preferably, described preparation is granule, capsule, tablet, pill, oral liquid or syrup.
Preferably, described auxiliary material includes antiplastering aid and controlled release agent.
Preferably, described antiplastering aid is plant amylum.
Preferably, described plant amylum is in starch from sweet potato, cornstarch, green starch, farina, Rhizoma Nelumbinis starch One or more.
Preferably, described controlled release agent is acetate succinate or odium stearate.
A kind of pharmaceutical composition treating anemopyretic cold, its preparation method and preparation that the present invention provides, this drug regimen Thing include the rush of 5~12 weight portions, the root of kudzu vine of 1~5 weight portion, the Radix Astragali of 2~6 weight portions, the zero of 3~10 weight portions Mound perfume, the black cohosh root of 1~5 weight portion, the capsule of weeping forsythia of 5~12 weight portions, the balloonflower root of 3~10 weight portions, the three of 0.3~2 weight portion 7th, the perilla leaf of 5~12 weight portions, the sweet wormwood of 5~12 weight portions, above-mentioned raw materials complement each other to treatment anemopyretic cold have aobvious The curative effect writing, and have no side effect, cheap.
Specific embodiment
In order to further appreciate that the present invention, with reference to embodiment, the preferred embodiments of the invention are described, but It is it should be appreciated that these descriptions are simply to further illustrate the features and advantages of the present invention rather than to patent requirements of the present invention Limit.
The invention provides a kind of pharmaceutical composition treating anemopyretic cold, including the raw material of following parts by weight:
Rush has functions that clearing away the heart-fire.In the present invention, the parts by weight of rush are 5~12 parts;In the present invention Embodiment in, the parts by weight of rush are 8~10 parts.
The root of kudzu vine has has expelling pathogenic factors from muscles and skin to bring down a fever, and promoting eruption promotes the production of body fluid to quench thirst, effect of Shengyang Zhixie.In the present invention, the weight of the root of kudzu vine Number is 1~5 part;In an embodiment of the present invention, the parts by weight of the root of kudzu vine are 2~3 parts.
The Radix Astragali has the effects such as enhancing body's immunity, resisting stress.In the present invention, the parts by weight of the Radix Astragali are 2~6 Part;In an embodiment of the present invention, the parts by weight of the Radix Astragali are 3~5 parts.
Holy basil has functions that wind-dispelling.In the present invention, the parts by weight of holy basil are 3~10 parts;The present invention's In other embodiment, the parts by weight of holy basil are 5~7 parts.
Black cohosh root has the endocrine effect of regulation.In the present invention, the parts by weight of black cohosh root are 1~5 part;At this In bright other embodiment, the parts by weight of black cohosh root are 2~3 parts.
The capsule of weeping forsythia has heat-clearing, removing toxic substances, dissipating bind, effect of detumescence.In the present invention, the parts by weight of the capsule of weeping forsythia are 5~12 parts; In other embodiments of the invention, the parts by weight of the capsule of weeping forsythia are 8~10 parts.
Balloonflower root has a surname's lung, profit pharynx, eliminating the phlegm, effect of apocenosis.In the present invention, the parts by weight of balloonflower root are 3~10 parts; In an embodiment of the present invention, the parts by weight of balloonflower root are 5~8 parts.
Pseudo-ginseng has dissipate stasis of blood hemostasis, the effect of detumescence ding-tong.In the present invention, the parts by weight of pseudo-ginseng are 0.3~2 part; In an embodiment of the present invention, the parts by weight of pseudo-ginseng are 0.5~1 part.
Perilla leaf has the effect of reason lung resolving sputum.In the present invention, the parts by weight of perilla leaf are 5~12 parts;At this In bright embodiment, the parts by weight of perilla leaf are 8~10 parts.
Sweet wormwood has clearing deficient heat, clear heat preventing malaria, effect of dehumidifying desinsection.The parts by weight of sweet wormwood are 5~12 parts;At this In inventive embodiment, the parts by weight of sweet wormwood are 8~10 parts.
The present invention provide treatment anemopyretic cold pharmaceutical composition, by using rush, the root of kudzu vine, the Radix Astragali, holy basil, The pharmaceutical composition that black cohosh root, the capsule of weeping forsythia, balloonflower root, pseudo-ginseng, perilla leaf and sweet wormwood prepare has extraordinary treatment to anemopyretic cold Imitate, and curative effect is stablized, had no side effect, and is suitable to Long-Time Service.
The present invention is not particularly limited to the source of all raw materials, is commercially available.
Present invention also offers a kind of preparation method of the pharmaceutical composition treating anemopyretic cold, comprise the following steps:
A) take black cohosh root, perilla leaf, the capsule of weeping forsythia, sweet wormwood and holy basil to be immersed in water, decoct, filter, obtaining a mixture Matter;
B) take rush, the root of kudzu vine, the Radix Astragali, balloonflower root and pseudo-ginseng to put in water and carry out decocting, filter, obtain b compounding substances;
C) after a compounding substances, b compounding substances being mixed, concentrate, be dried, pulverize, that is, obtain pharmaceutical composition.
The source of all raw materials of the present invention is not particularly limited, and is commercially available.
Wherein, rush, the root of kudzu vine, the Radix Astragali, holy basil, black cohosh root, the capsule of weeping forsythia, balloonflower root, pseudo-ginseng, perilla leaf and sweet wormwood be all ibid Described, will not be described here.
In the present invention, black cohosh root, perilla leaf, pseudo-ginseng, sweet wormwood and holy basil are immersed in water, decoct, filter, obtain a Compounding substances.In an embodiment of the present invention, decocting time is 2~4h.
In the present invention, rush, the root of kudzu vine, the Radix Astragali, balloonflower root and the capsule of weeping forsythia are put into and are carried out in water decocting, filter, and obtain b mixing Material;In an embodiment of the present invention, decocting time is 6~8h.
The short black cohosh root of decocting time, perilla leaf, pseudo-ginseng, sweet wormwood, holy basil can be with the rush of decocting time length, Pueraria lobotas Root, the Radix Astragali, balloonflower root, the property of medicine of the capsule of weeping forsythia complement each other so that pharmaceutical composition has very high curative effect, and curative effect is stable, no There is toxic and side effect.
Obtain a compounding substances, after b compounding substances, be mixed uniformly, concentrate, be dried, pulverize, obtain pharmaceutical composition.
The preparation method of the pharmaceutical composition for the treatment of hot blast flu that the present invention provides, by raw material is separately decocted, can To make full use of the property of medicine of medicinal material so that medicinal material is best to the curative effect of anemopyretic cold, and curative effect is stablized, is had no side effect, and is suitable to grow Phase uses.
Present invention also offers a kind of preparation, by pharmaceutical composition and the pharmaceutically acceptable auxiliary material for the treatment of anemopyretic cold Make.
Wherein, pharmaceutical composition ibid, will not be described here.
In an embodiment of the present invention, preparation is granule, capsule, tablet, pill, oral liquid or syrup.
In an embodiment of the present invention, auxiliary material includes antiplastering aid and controlled release agent;In present invention others embodiment, resist Stick is plant amylum;In a further embodiment, plant amylum is selected from starch from sweet potato, cornstarch, green starch, potato One or more of starch, Rhizoma Nelumbinis starch.
In order that the drug effect of preparation has stable persistence, in an embodiment of the present invention, controlled release agent is acetate succinate Acid esters or odium stearate.
The preparation that the present invention provides, said preparation has extraordinary curative effect to anemopyretic cold, and efficacy stability is persistently, does not have poison Side effect.
In order to further illustrate the present invention, the medicine group of the treatment anemopyretic cold present invention being provided with reference to embodiment Compound, its preparation method and preparation are described in detail, but they can not be interpreted as limiting the scope of the present invention.
In following examples raw material used be commercially available.
Embodiment 1
Weigh raw material: 50g rush, the 10g root of kudzu vine, the 30g Radix Astragali, 50g holy basil, 20g black cohosh root, 80g by following weight The capsule of weeping forsythia, 100g balloonflower root, 5g pseudo-ginseng, 120g perilla leaf and 100g sweet wormwood.
A) take black cohosh root, perilla leaf, pseudo-ginseng, sweet wormwood and holy basil to be immersed in water, after decocting 3h, filter, obtain a mixing Material;
B) take rush, the root of kudzu vine, the Radix Astragali, balloonflower root and the capsule of weeping forsythia to put in water and carry out decocting 7h, filter, obtain b compounding substances;
C) after a compounding substances, b compounding substances being mixed, concentrate, be dried, pulverize, that is, obtain pharmaceutical composition;
Add 33g cornstarch and 16.7g acetate succinate in pharmaceutical composition, make granule.
Embodiment 2
Weigh raw material: 80g rush, the 40g root of kudzu vine, the 40g Radix Astragali, 60g holy basil, 30g black cohosh root, 100g by following weight The capsule of weeping forsythia, 50g balloonflower root, 10g pseudo-ginseng, 90g perilla leaf and 80g sweet wormwood.
A) take black cohosh root, perilla leaf, pseudo-ginseng, sweet wormwood and holy basil to be immersed in water, after decocting 3h, filter, obtain a mixing Material;
B) take rush, the root of kudzu vine, the Radix Astragali, balloonflower root and the capsule of weeping forsythia to put in water and carry out decocting 6h, filter, obtain b compounding substances;
C) after a compounding substances, b compounding substances being mixed, concentrate, be dried, pulverize, that is, obtain pharmaceutical composition;
Add 34.4g green starch and 11.5 acetate succinates in pharmaceutical composition, make pill.
Embodiment 3
Weigh raw material by following weight: 100g rush, the 50g root of kudzu vine, the 60g Radix Astragali, 100g holy basil, 10g black cohosh root, The 90g capsule of weeping forsythia, 30g balloonflower root, 20g pseudo-ginseng, 100g perilla leaf and 120g sweet wormwood.
A) take black cohosh root, perilla leaf, pseudo-ginseng, sweet wormwood and holy basil to be immersed in water, after decocting 3h, filter, obtain a mixing Material;
B) take rush, the root of kudzu vine, the Radix Astragali, balloonflower root and the capsule of weeping forsythia to put in water and carry out decocting 8h, filter, obtain b compounding substances;
C) after a compounding substances, b compounding substances being mixed, concentrate, be dried, pulverize, that is, obtain pharmaceutical composition;
Add 40g starch from sweet potato and 16g odium stearate in pharmaceutical composition, make oral liquid.
Embodiment 4
Weigh raw material: 90g rush, the 30g root of kudzu vine, the 20g Radix Astragali, 70g holy basil, 40g black cohosh root, 120g by following weight The capsule of weeping forsythia, 80g balloonflower root, 3g pseudo-ginseng, 80g perilla leaf and 90g sweet wormwood.
A) take black cohosh root, perilla leaf, pseudo-ginseng, sweet wormwood and holy basil to be immersed in water, after decocting 3h, filter, obtain a mixing Material;
B) take rush, the root of kudzu vine, the Radix Astragali, balloonflower root and the capsule of weeping forsythia to put in water and carry out decocting 7h, filter, obtain b compounding substances;
C) after a compounding substances, b compounding substances being mixed, concentrate, be dried, pulverize, that is, obtain pharmaceutical composition;
Add 373g Rhizoma Nelumbinis starch and 12.4g acetate succinate in pharmaceutical composition, make capsule.
Embodiment 5
Weigh raw material: 120g rush, the 20g root of kudzu vine, the 50g Radix Astragali, 30g holy basil, 50g black cohosh root, 50g by following weight The capsule of weeping forsythia, 70g balloonflower root, 7g pseudo-ginseng, 50g perilla leaf and 50g sweet wormwood.
A) take black cohosh root, perilla leaf, pseudo-ginseng, sweet wormwood and holy basil to be immersed in water, after decocting 2h, filter, obtain a mixing Material;
B) take rush, the root of kudzu vine, the Radix Astragali, balloonflower root and the capsule of weeping forsythia to put in water and carry out decocting 7h, filter, obtain b compounding substances;
C) after a compounding substances, b compounding substances being mixed, concentrate, be dried, pulverize, that is, obtain pharmaceutical composition;
Add 32.4g farina and 16.2g odium stearate in pharmaceutical composition, make tablet.
First, safety testing:
The product mix grind into powder of Example 1~5.
Using the medicinal powder of above-mentioned gained as trial drug, with the small white mouse of body weight 18-20g male and female half and half as experimental animal, Totally 150, be divided into 5 groups, respectively the medicine of gavage variable concentrations, concentration be respectively 10mg/ml, 40mg/ml, 60mg/ml, 80mg/ml, 100mg/ml, administered volume is 40ml/kg, to gastric infusion in mouse one day 3 times, accumulation gastric infusion volume For 100ml/kg.Observe 7, have no overt toxicity reaction and the reaction of pawpaw enteron aisle.Through visually observing after dissection, main organs Non Apparent Abnormality.
The small white mouse of body weight 18-20g male and female half and half is experimental animal, totally 80, is divided into two groups, carries out long term toxicity examination Test, one group of administration concentration is 60mg/ml, and administered volume is 40ml/kg;Another group is isopyknic distilled water, continuously gavages 3 Individual month, carry out long term toxicity test.Long term toxicity test result shows, the general behavior activity of experimental animal is with body weight increase just Often, to hematological indices, the organ coefficient of hepatic and renal function and main organs all has no significant effect, and the no obvious pathology of main organs damages Wound, shows that medicine is non-toxic.
2nd, the preparation that embodiment 1~5 obtains is carried out clinical testing, result is as follows:
1st, experimenter selects: selects the anemopyretic cold patient totally 600 that in March, 2011~certain hospital accepts for medical treatment so far, wherein Male patient 285, female patient 315.
2nd, packet design: all patients are randomly divided into six groups, respectively experimental group 1, experimental group 2, experimental group 3, experimental group 4th, experimental group 5 and control group, each 100, six groups of patients, in the aspects such as age, the state of an illness no significant difference, have comparativity.Wherein Experimental group 1~5 is respectively using the preparation of embodiment 1~5 preparation.
3rd, instructions of taking: experimental group 1~5 takes the preparation of various formulations respectively, three times a day, 2 tablets once, and warm is taken 10 days.Control group uses other drugs (as medicines such as compound acetaminophen alkyl amines).
4th, curative effect judging standard
Cure: patient's anemopyretic cold symptom disappears, body surface recovers normal;
Effective: patient's anemopyretic cold symptom gradually mitigates or symptom disappears;
Invalid: anemopyretic cold symptom no takes a turn for the better;
Total effective rate=(curing number of cases+effective number of cases)/case load.
5th, result is as shown in table 1
Table 1 experimental group 1~5 and the treatment results of control group
Above a kind of pharmaceutical composition treating anemopyretic cold, its preparation method and the preparation that the present invention provides is carried out Detailed introduction, specific case used herein is set forth to the principle of the present invention and embodiment, above example Explanation be only intended to help understand the method for the present invention and its core concept it is noted that common for the art For technical staff, under the premise without departing from the principles of the invention, the present invention can also be carried out with some improvement and modify, these Improve and modify and also fall in the protection domain of the claims in the present invention.

Claims (10)

1. a kind of pharmaceutical composition treating anemopyretic cold is it is characterised in that include the raw material of following parts by weight:
2. pharmaceutical composition as claimed in claim 1 is it is characterised in that include the raw material of following parts by weight:
3. a kind of as claimed in claim 1 or 2 treatment anemopyretic cold pharmaceutical composition preparation method it is characterised in that Comprise the following steps:
A) take black cohosh root, perilla leaf, pseudo-ginseng, sweet wormwood and holy basil to be immersed in water, decoct, filter, obtaining a compounding substances;
B) take rush, the root of kudzu vine, the Radix Astragali, balloonflower root and the capsule of weeping forsythia to put in water and carry out decocting, filter, obtain b compounding substances;
C) after a compounding substances, b compounding substances being mixed, concentrate, be dried, pulverize, that is, obtain pharmaceutical composition.
4. preparation method as claimed in claim 3 is it is characterised in that decocting time described in step a) is 2~4h;Step b) Described in decocting time be 6~8h.
5. a kind of preparation is it is characterised in that the treatment pharmaceutical composition of anemopyretic cold described in claim 1 or 2 and pharmacy Upper acceptable auxiliary material is made.
6. preparation as claimed in claim 5 it is characterised in that described preparation be granule, capsule, tablet, pill, oral Liquid or syrup.
7. preparation as claimed in claim 5 is it is characterised in that described auxiliary material includes antiplastering aid and controlled release agent.
8. preparation as claimed in claim 7 is it is characterised in that described antiplastering aid is plant amylum.
9. preparation as claimed in claim 8 is it is characterised in that described plant amylum is selected from starch from sweet potato, cornstarch, mung bean One or more of starch, farina, Rhizoma Nelumbinis starch.
10. preparation as claimed in claim 7 is it is characterised in that described controlled release agent is acetate succinate or odium stearate.
CN201610795111.5A 2016-08-31 2016-08-31 Medicinal composition for treating wind-heat type common cold, preparation method thereof and preparation Pending CN106334040A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1425449A (en) * 2003-01-09 2003-06-25 鲁南制药股份有限公司 Traditional Chinese medicine composition for curing wind-heat type cold and its preparing method
CN102429980A (en) * 2011-12-14 2012-05-02 钟跃平 Cold granules and preparation method thereof
CN105770074A (en) * 2016-04-20 2016-07-20 山东明仁福瑞达制药股份有限公司 Traditional Chinese medicine composition for treating wind-heat common cold and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1425449A (en) * 2003-01-09 2003-06-25 鲁南制药股份有限公司 Traditional Chinese medicine composition for curing wind-heat type cold and its preparing method
CN102429980A (en) * 2011-12-14 2012-05-02 钟跃平 Cold granules and preparation method thereof
CN105770074A (en) * 2016-04-20 2016-07-20 山东明仁福瑞达制药股份有限公司 Traditional Chinese medicine composition for treating wind-heat common cold and preparation method thereof

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