CN106309736A - Anti-fatigue traditional Chinese medicine composition as well as preparation method and application thereof - Google Patents
Anti-fatigue traditional Chinese medicine composition as well as preparation method and application thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention disclsoes an anti-fatigue traditional Chinese medicine composition as well as a preparation method and application thereof. The anti-fatigue traditional Chinese medicine composition provided by the invention is prepared from the following medicinal raw materials in parts by weight: 20-50 parts of phyllanfhus fruits, 20-50 parts of radix astragali seu hedysari and 10-30 parts of wolfberry fruits. The anti-fatigue traditional Chinese medicine composition provided by the invention can be used for remarkably alleviating a fatigue state, particularly the fatigue state of an organism under a low-air-pressure environment.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, the Chinese medicine composition of a kind of resisting fatigue, further relate to this Chinese drug-treated group
The preparation method of compound and purposes.
Background technology
Fatigue is the physiological phenomenon of a kind of complexity, body under certain condition, due to long-time or overwrought muscle power
Or mental activity and the labor efficiency that causes tends to decline, may result in work efficiency reduces, and mistake and accident increases.After tired generation
If can not get recovering in time, gradually accumulating, also resulting in overwork, make body generation endocrine regulation, immunity degradation, even
Organic disease occurs, becomes the key factor threatening human health.
Except the fatigue on ordinary meaning, plateau low pressure also cause body to occur fatigue symptom, work capacity substantially drop
Low.Plateau elevation typically at more than 3000m, great majority without altitutde training humans and animals arrive this height of 3000m with
After, due to decrease in oxygen partial pressure in atmospheric pressure, low-oxygen environment toleration is reduced by body, it is difficult to adapts to and causes anoxia, all can go out
Now obvious fatigue symptom and sign；Exceeding this height, the adaptive change of the aspects such as physiology, biochemistry and form will become
More come substantially, and there is obvious biological property.Under hypobaric, the work capacity of body can be generally reduced, seriously
Person is little to do the operation of high intensity.
The existing multiple medicine with fatigue alleviating effect and health food in the market, and the most expensive.Literary composition
Offer research report plurality of Chinese compound recipe and be respectively provided with certain resisting fatigue effect.The China of Application No. 201110007916.6 is specially
Profit application discloses a kind of pharmaceutical composition with antifatigue effect, by the Radix Astragali, Radix Ginseng, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Rhizoma Cyperi and Fructus Lycii
Form in Chinese medicine.The Chinese patent application of Application No. 200810033746.7 discloses a kind of anti-fatigue Chinese medicinal composition, contains
There are pharmaceutically acceptable carrier and the raw medicinal material of effective dose or its water extract or aqueous organic solvent extract, described
Raw medicinal material contains selected from Herba Epimedii, Cordyceps, Cornu Cervi Pantotrichum, the Cortex Eucommiae, Fructus Corni, Fructus Lycii, Radix Dipsaci, Rhizoma Cibotii, Radix Ginseng, the West
Ginseng, the Radix Astragali, Colla Corii Asini, Radix Rehmanniae Preparata, Fructus Mori, Folium Isatidis, Fructus Forsythiae, Radix Glycyrrhizae, Flos Chrysanthemi Indici, Cortex Moutan, Folium Ginkgo or Stigma Croci multiple
Medical material or their water extract or the extract of aqueous organic solvent.Above-mentioned pharmaceutical composition is respectively provided with certain resisting fatigue
Effect, but not for the fatigue symptom under hypobaric.
Accordingly, it would be desirable to one have definite resisting fatigue effect reliably, particularly have under hypobaric definite anti-
The Chinese medicine composition of tired effect.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition, this Chinese medicine composition has significant resisting fatigue effect, special
It not that hypobaric has significant resisting fatigue effect.
It is a further object of the present invention to provide the preparation method of this Chinese medicine composition.
Another object of the present invention is to provide the Chinese medicine preparation containing this Chinese medicine composition.
It is yet another object of the invention to provide the purposes of this Chinese medicine composition.
It is an object of the invention to be achieved through the following technical solutions.
The present invention provides a kind of Chinese medicine composition for resisting fatigue, and described compositions is by the component including following crude drug
Make:
Fructus Phyllanthi 20～50 weight portion, the Radix Astragali 20～50 weight portion and Fructus Lycii 10～30 weight portion.
The Chinese medicine composition of the present invention, it is preferable that said composition is made up of the component including following crude drug:
Fructus Phyllanthi 25～45 weight portion, the Radix Astragali 30～45 weight portion and Fructus Lycii 15～30 weight portion.
The Chinese medicine composition of the present invention, it is preferable that said composition is made up of the component including following crude drug:
Fructus Phyllanthi 30 weight portion, the Radix Astragali 35 weight portion and Fructus Lycii 25 weight portion；Or
Fructus Phyllanthi 32.5 weight portion, the Radix Astragali 37.5 weight portion and Fructus Lycii 20 weight portion；Or
Fructus Phyllanthi 37.5 weight portion, the Radix Astragali 37.5 weight portion and Fructus Lycii 25 weight portion.
The Chinese medicine composition of the present invention, it is preferable that described component only includes described crude drug.
The present invention also provides for the preparation method of described Chinese medicine composition.Preferably, described preparation method is selected from being pulverized and mixed
Method, water extraction method or ethanol water extraction method.
According to an embodiment of the invention, described preparation method includes: Fructus Phyllanthi, the Radix Astragali and Fructus Lycii are pulverized,
Mix homogeneously, obtains described Chinese medicine composition.
According to another implementation of the invention, described preparation method comprises the steps:
(1) by Fructus Phyllanthi, the Radix Astragali and Fructus Lycii use water heating and refluxing extraction or supersound extraction 1～5 times, add every time based on
Fructus Phyllanthi, the Radix Astragali and the water of the 1 of Fructus Lycii gross weight～20 times amount, extract 0.5～5 hour every time, filters, and filtrate merges；
(2) described filtrate is concentrated.
According to yet further embodiment of the invention, described preparation method comprises the steps:
(1) Fructus Phyllanthi, the Radix Astragali and Fructus Lycii are heated to reflux or supersound extraction 1～5 times, add every time based on Fructus Phyllanthi,
The Radix Astragali and the ethanol water that concentration is 20～100vol% of the 1 of Fructus Lycii gross weight～20 times amount, extract 0.5～5 every time
Hour, to filter, filtrate merges；
(2) described filtrate is concentrated.
The present invention also provides for the Chinese medicine preparation of a kind of resisting fatigue, and described Chinese medicine preparation comprises above-mentioned Chinese medicine composition, and wraps
Containing pharmaceutically acceptable adjuvant.
The present invention also provides for described Chinese medicine composition for preparing prevention or the medicine of fatigue alleviating or the use of health food
On the way.
Effect experiment confirms, uses Fructus Phyllanthi, the Radix Astragali and this three tastes crude drug of Fructus Lycii, and with the special ratios of the present invention
After compatibility, the Chinese medicine composition prepared can prevent fatigue, and can rapidly, fatigue alleviating state effectively, particularly prevent
Fatigue state with the body alleviated under plateau low pressure environment.
Detailed description of the invention
Below in conjunction with concrete real-time mode, the present invention is described in more detail, but protection scope of the present invention does not limit
In this.
In the present invention, the concentration of ethanol water refers to the concentration expressed in percentage by volume of wherein ethanol, i.e. vol%.In the present invention,
When the concentration of described ethanol water is 100vol%, refer to dehydrated alcohol.
" pharmaceutically acceptable " of the present invention means that it can be used for preparing medicine or preparation, and it is the most safe and nontoxic
And neither or not the most not undesirable other side, and include its for veterinary use and mankind's medicine
It is acceptable that thing uses.
In the present invention, described Fructus Phyllanthi is that Euphorbiaceae (Euphorbiaceae) Leafflower (Phyllanthus) fallen leaves fill
Wood or the dry mature fruit of dungarunga Fructus Phyllanthi Phyllanthus emblica L..The described Radix Astragali is that leguminous plant Mongolia is yellow
Stilbene Astragalus membranaceus (Fisch.) Bge.var.Mongholicus (Bge.) Hsiao or Radix Astragali
The dry root of Astragalus membranaceus (Fisch.) Bge..Described Fructus Lycii, also known as Fructus Lycii, is plant of Solanaceae Ningxia
The dry mature fruit of Fructus Lycii Lycium barbarum L..
<Chinese medicine composition>
The Chinese medicine composition of the present invention, is made up of the component including the crude drug of Fructus Phyllanthi, the Radix Astragali and Fructus Lycii, three
The weight proportion of person is Fructus Phyllanthi 20～50 weight portion, the Radix Astragali 20～50 weight portion and Fructus Lycii 10～30 weight portion.These three kinds
Crude drug has significant resisting fatigue effect with the Chinese medicine composition that described proportioning is made, and particularly has under hypobaric
Significantly resisting fatigue effect.One according to the present invention preferred embodiment, and the Chinese medicine composition of the present invention is as follows by including
The component of the crude drug of weight proportion is made: Fructus Phyllanthi 25～45 weight portion, the Radix Astragali 30～45 weight portion and Fructus Lycii 15～30
Weight portion.A preferred embodiment according to the present invention, the Chinese medicine composition of the present invention is by including following weight proportion
The component of crude drug make: Fructus Phyllanthi 30～40 weight portion, the Radix Astragali 35～40 weight portion and Fructus Lycii 18～28 weight portion.
According to an embodiment of the invention, the Chinese medicine composition of the present invention is by the crude drug including following weight proportion
Component make: Fructus Phyllanthi 30 weight portion, the Radix Astragali 35 weight portion and Fructus Lycii 25 weight portion.
According to another embodiment of the present invention, the Chinese medicine composition of the present invention is by the crude drug including following weight proportion
Component make: Fructus Phyllanthi 32.5 weight portion, the Radix Astragali 37.5 weight portion and Fructus Lycii 20 weight portion.
According to yet another embodiment of the present invention, the Chinese medicine composition of the present invention is by the crude drug including following weight proportion
Component make: Fructus Phyllanthi 37.5 weight portion, the Radix Astragali 37.5 weight portion and Fructus Lycii 25 weight portion.
In addition to Fructus Phyllanthi, the Radix Astragali and Fructus Lycii, the Chinese medicine composition of the present invention prepare raw material can containing or not
Containing other Pharmaceutical ingredients.According to an embodiment of the invention, the Chinese medicine composition of the present invention, its Pharmaceutical ingredients is only by upper
State the Fructus Phyllanthi of weight proportion, the Radix Astragali and Fructus Lycii composition, and do not comprise other Pharmaceutical ingredients.
In the present invention, described Fructus Phyllanthi, the Radix Astragali and Fructus Lycii all can use health product or processed product.According to the present invention one
Embodiment, the described Radix Astragali is Radix Astragali or Radix Astragali Preparata, preferably Radix Astragali Preparata.
<preparation method>
The Chinese medicine composition of the present invention can use the method for being pulverized and mixed, water extraction method or ethanol water extraction method to be prepared into
Arrive.
Described is pulverized and mixed method, is Fructus Phyllanthi, the Radix Astragali, Fructus Lycii to be pulverized, and mix homogeneously obtains described Chinese medicine composition
Thing.Specifically, mix homogeneously after Fructus Phyllanthi, the Radix Astragali and Fructus Lycii individually can being pulverized, or by Fructus Phyllanthi, the Radix Astragali and Fructus Lycii
Pulverize again after sub-mix homogeneously, obtain the Chinese medicine composition of the present invention.The particle diameter of described pulverizing is as the criterion with applicable preparation.
Described water extraction method can be selected from infusion method, decocting method, heating and refluxing extraction method or ultrasonic extraction.According to
An embodiment of the invention, described water extraction method is Fructus Phyllanthi, the Radix Astragali, Fructus Lycii to be extracted respectively, filters, by filtrate
Merge, concentrate, be dried alternatively, obtain the Chinese medicine composition of the present invention.According to another implementation of the invention, institute
Stating water extraction method is to use water extraction after Fructus Phyllanthi, the Radix Astragali, Fructus Lycii mixing, filters, filtrate is concentrated, do alternatively
Dry, obtain the Chinese medicine composition of the present invention.
According to an embodiment of the invention, described preparation method comprises the steps:
(1) by Fructus Phyllanthi, the Radix Astragali and Fructus Lycii use water heating and refluxing extraction or supersound extraction 1～5 times, add every time based on
Fructus Phyllanthi, the Radix Astragali and the water of the 1 of Fructus Lycii gross weight～20 times amount, extract 0.5～5 hour every time, filters, and filtrate is merged；
(2) described filtrate is concentrated, obtain described Chinese medicine composition.
In step (1), it is preferable that extraction time is 1～3 time, more preferably 2～3 times；The weight every time adding water is remaining
5～12 times of Gan Zi, the Radix Astragali and Fructus Lycii gross weight, more preferably 6～10 times；Extraction time is 0.5～3 hour every time, more
It is preferably 1～2 hour.
According to an embodiment of the invention, in step (1), by Fructus Phyllanthi, the Radix Astragali and Fructus Lycii heating and refluxing extraction 1
～3 times, add based on Fructus Phyllanthi, the Radix Astragali and the water of the 5 of Fructus Lycii gross weight～12 times amount every time, extract 0.5～3 little every time
Time.
In the present invention, it is preferable that in step (1), extract after Fructus Phyllanthi, the Radix Astragali and Fructus Lycii are soaked, during immersion
Between be 0.2～2 hour, more preferably 0.5～1 hour.
In the present invention, described ethanol water extraction method can be selected from infusion process, heating and refluxing extraction method, supersound extraction
Method or percolation.The concentration of described ethanol water is 20～100vol%, preferably 30～95vol%, more preferably 40
～75vol%, it is further preferably 50～75vol%.According to an embodiment of the invention, described ethanol water extraction method
It is that Fructus Phyllanthi, the Radix Astragali, Fructus Lycii are extracted respectively, filters, filtrate is merged, concentrate, be dried alternatively, obtain the present invention
Chinese medicine composition.According to another implementation of the invention, described ethanol water extraction method be by Fructus Phyllanthi, the Radix Astragali,
Extract with ethanol water after Fructus Lycii mixing, filter, filtrate is concentrated, is dried alternatively, obtains the Chinese medicine of the present invention
Compositions.
According to one embodiment of the present invention, described extracting method comprises the steps:
(1) Fructus Phyllanthi, the Radix Astragali and Fructus Lycii are heated to reflux or supersound extraction 1～5 times, add every time based on Fructus Phyllanthi,
The Radix Astragali and the ethanol water that concentration is 20～100% of the 1 of Fructus Lycii gross weight～20 times amount, extract 0.5～5 little every time
Time, filter, filtrate is merged；
(2) described filtrate is concentrated, obtain described Chinese medicine composition.
In step (1), it is preferable that extraction time is preferably 1～4 time, more preferably 2～3 times；The ethanol water every time added
The concentration of solution is 40～75vol%, more preferably 50～75vol%；The weight of the ethanol water every time added is emblic
Son, the Radix Astragali and 2～15 times of Fructus Lycii gross weight, more preferably 5～15 times；Extraction time is 1～3 hour every time, more preferably
It it is 1～2 hour.
According to an embodiment of the invention, in step (1), Fructus Phyllanthi, the Radix Astragali and Fructus Lycii are heated to reflux or super
Sound extracts 1～4 time, add every time concentration based on Fructus Phyllanthi, the Radix Astragali and the 2 of Fructus Lycii gross weight～15 times amount be 40～
The ethanol water of 75vol%, extracts 1～3 hour every time.
In the present invention, in step (1), it is preferable that Fructus Phyllanthi, the Radix Astragali and Fructus Lycii are added after ethanol water soaks and carries
Taking, soak time is 0.2～2 hour, more preferably 0.5～1 hour.
In above-mentioned water extraction method and ethanol water extraction method, described Fructus Phyllanthi, the Radix Astragali and Fructus Lycii can directly with
Decoction pieces feeds intake, it is possible to feed intake after suitably pulverizing again.
Should be appreciated that above-mentioned embodiment is only currently preferred preparation method, and the preparation method of the present invention is also
It is not limited to embodiment given above.The Chinese medicine composition of the crude drug composition preparation of all employing present invention, due to its raw material
The property of medicine of medicine, compatibility relationship are constant, are respectively provided with the effect of prevention and fatigue alleviating.
<Chinese medicine preparation>
The Chinese medicine preparation of the present invention is the preparation using above-mentioned Chinese medicine composition to prepare as Pharmaceutical ingredients.Specifically,
The Chinese medicine preparation of the present invention contains above-mentioned Chinese medicine composition, especially with the Chinese drug-treated group using the preparation method of the present invention to prepare
Compound, can contain or not contain other Pharmaceutical ingredients, and containing pharmaceutically acceptable adjuvant.In the present invention, described pharmacy
Those known in above acceptable adjuvant can be field, include but not limited to starch, Icing Sugar, dextrin, lactose, microcrystalline cellulose
Element, mannitol, water, vegetable oil etc..The pharmaceutical dosage forms of the present invention is not particularly limited.
According to an embodiment of the invention, described Chinese medicine preparation is medicinal tea, such as by Fructus Phyllanthi, the Radix Astragali, Fructus Lycii
Son encloses tea bag by metering after being pulverized and mixed, and makes the resisting fatigue medicinal tea of teabag form.
According to another implementation of the invention, described Chinese medicine preparation is that granule, tablet (include buccal tablet, chew
Sheet), pill (including drop pill) or capsule, Chinese medicine composition therein can use form of extract, for example with the present invention
Water extraction method or the Chinese medicine composition for preparing of ethanol water extraction method.
According to the another embodiment of the present invention, the Chinese medicine preparation of the present invention be beverage, decoction, oral liquid, mixture or
Syrup, Chinese medicine composition therein can use form of extract, and water extraction method or ethanol water for example with the present invention carry
Follow the example of the Chinese medicine composition prepared.
<pharmaceutical applications>
The Chinese medicine composition of the present invention can be used for preparation prevention or the medicine of fatigue alleviating or health food, especially for
Tired medicine under preparation prevention or alleviation hypobaric or health food.Confirmed by effect experiment, employing Fructus Phyllanthi,
The Radix Astragali and Fructus Lycii are as crude drug, and use the Chinese medicine composition that the weight proportion of the present invention prepares, and have significantly
Resisting fatigue effect, particularly has significant resisting fatigue effect, hence it is evident that be better than three and be used alone under hypobaric.Separately
Outward, the crowd on entrance plateau is by taking the Chinese medicine composition of the present invention for the first time, its tolerance degree to plateau low pressure environment
Crowd apparently higher than non-drug administration.
Below in conjunction with specific embodiment, the present invention is further illustrated, but protection scope of the present invention is not limited to
This.
Embodiment 1
Take Fructus Phyllanthi 37.5 weight portion, the Radix Astragali 37.5 weight portion and Fructus Lycii 25 weight portion, supersound extraction 3 times, add every time
The concentration of 13 times amount entering crude drug gross weight is 55vol% ethanol water, extracts 40min every time, filters, and filtrate merges,
Rotary evaporation concentrates.
Embodiment 2
Take Fructus Phyllanthi 37.5 weight portion, the Radix Astragali 37.5 weight portion and Fructus Lycii 25 weight portion, soak 30min post-heating
Reflux, extract, 2 times, each amount of water is 10 times amount of crude drug gross weight, and each extraction time is 2 hours, filters, filtrate
Merging, rotary evaporation concentrates.
Embodiment 3
Take Fructus Phyllanthi 25 weight portion, the Radix Astragali 30 weight portion and Fructus Lycii 15 weight portion, supersound extraction 3 times, add former every time
The ethanol water that concentration is 70vol% of 8 times amount of material medicine gross weight, extracts 1 hour for the 1st time, the 2nd, 3 each extractions
40min, filters, and filtrate merges, and concentrates.
Embodiment 4
Take Fructus Phyllanthi 30 weight portion, the Radix Astragali 40 weight portion and Fructus Lycii 18 weight portion, heating and refluxing extraction 3 times, add every time
Entering the ethanol water that concentration is 70vol% of 10 times amount of crude drug gross weight, extract 50min every time, filter, filtrate is closed
And, concentrate.
Embodiment 5
Take Fructus Phyllanthi 20 weight portion, the Radix Astragali 50 weight portion and Fructus Lycii 10 weight portion, use 20 times of crude drug gross weight
Amount concentration is that the ethanol water percolation of 70vol% extracts 6 hours, is concentrated by percolate.
Embodiment 6
Take Fructus Phyllanthi 30 weight portion, the Radix Astragali 35 weight portion, Fructus Lycii 25 weight portion, be crushed to 24 mesh respectively, mix homogeneously,
Obtain the Chinese medicine composition of the present invention.
Embodiment 7
Taking Fructus Phyllanthi 32.5 weight portion, the Radix Astragali 37.5 weight portion and Fructus Lycii 20 weight portion, add water heating and refluxing extraction 3
Secondary, add 15 times amount water of crude drug gross weight every time, extract 1 hour every time, filter, filtrate merges；Described filtrate is concentrated.
Embodiment 8
The Chinese medicine composition of embodiment 7 is dried, pulverizes, then weighs 18 weight portions, add soluble starch 82 weight
Part, microcrystalline Cellulose and lactose are appropriate, mix homogeneously, and less than 80 DEG C hot air dryings remove a small amount of moisture, then add wetting agent
(90vol% ethanol water) makes soft material, makes wet grain with squash type comminutor, is dried granulate, makes granule.
Embodiment 9
The Chinese medicine composition of embodiment 3 is dried, pulverizes, then weighs 20 weight portions, add sterilized water 80 weight portion, fill
Divide and dissolve, add the tween 80 of 1.0wt%, the potassium sorbate of 0.15wt% and stevioside appropriate, mix homogeneously, filters, system
Become oral liquid.
Embodiment 10
The Chinese medicine composition of embodiment 6 is enclosed tea pouch, obtains bag tea agent.
Following concrete effect experiment proves that the pharmaceutical composition of the present invention has resisting fatigue effect.
<laboratory animal, medicine and environment>
The laboratory animal, medicine and the simulation lower pressure environment that use in mouse swimming test are specific as follows:
Laboratory animal:
Below in experiment, the mice of employing is healthy kunming mice, LAF/SPF rank, and body weight 18～22g is reached by Chengdu
Large bio tech ltd provides.Experimental situation is: temperature 24 ± 0.5 DEG C, and humidity is maintained at 60 ± 2%, room light line traffic control
System is in normal circadian rhythm (bright light during morning 8), and animal freely obtains food and water.
Experimental agents:
(1) Chinese medicine composition 1 of the present invention: the weight portion of embodiment 1 is operated in grams, it is thus achieved that concentrate,
Then take the 3/5 of this concentrate, be settled to 200ml with distilled water, to obtain final product.
(2) Chinese medicine composition 2 of the present invention: the weight portion of embodiment 2 is operated in grams, it is thus achieved that concentrate,
Then take the 3/5 of this concentrate, be settled to 200ml with distilled water, to obtain final product.
(3) Fructus Phyllanthi extracting solution: take Fructus Phyllanthi 60g, soaks 30min post-heating reflux, extract, 2 times, and each adds water
Amount is 600ml, 2 hours each extraction times, filters, and filtrate merges, and rotary evaporation concentrates, and is settled to 200ml with distilled water, i.e.
?.
(4) Radix Astragali extractive solution: take Radix Astragali 60g, soaks 30min post-heating reflux, extract, 2 times, and each amount of water is
600ml, 2 hours each extraction times, filters, and filtrate merges, and rotary evaporation concentrates, and is settled to 200ml with distilled water, to obtain final product.
(5) Fructus Lycii extracting solution: take Fructus Lycii 60g, soaks 30min post-heating reflux, extract, 2 times, and each adds water
Amount is 600ml, 2 hours each extraction times, filters, and filtrate merges, and rotary evaporation concentrates, and is settled to 200ml with distilled water, i.e.
?.
Experimental situation:
Simulation lower pressure environment: use the vacuum desiccator of top tool rubber stopper, its rubber stopper makes a call to two holes, and rubber is passed through in a hole
Sebific duct connects vacuum pump, and another hole connects air by rubber tube, pipe clamp control air turnover amount, bleed and make vacuum meter pointer
Reach 0.03～0.035mPa and balance as standard, the lower pressure environment caused with this simulated high altitude lower pressure environment or other reasons.
<mouse forced swimming>
1. experimental technique
Taking kunming mice 70, be randomly divided into 7 groups, often group 10, each group is as follows:
Normal pressure blank group: under atmospheric pressure environment, every day gavage 20ml/kg normal saline；
Low pressure+blank group: under lower pressure environment, every day gavage 20ml/kg normal saline；
Low pressure+Chinese medicine composition of the present invention 1 group (be called for short the present invention 1 group): under lower pressure environment, every day gavage 20ml/kg this
Invention Chinese medicine composition 1；
Low pressure+Chinese medicine composition of the present invention 2 groups (be called for short the present invention 2 groups): under lower pressure environment, every day gavage 20ml/kg this
Invention Chinese medicine composition 2；
Low pressure+emblic subgroup: under lower pressure environment, every day gavage 20ml/kg Fructus Phyllanthi extracting solution；
Low pressure+Radix Astragali group: under lower pressure environment, every day gavage 20ml/kg Radix Astragali extractive solution；
Low pressure+Fructus Lycii subgroup: under lower pressure environment, every day gavage 20ml/kg Fructus Lycii extracting solution.
Above-mentioned mouse stomach dosage 20ml/kg, the crude drug amount that equivalent 6g/kg, i.e. mice every kg body weight is administered is 6g.Folding
The crude drug amount synthesizing the administration that people's consumption is 24g/50kg, i.e. people every 50kg body weight is 24g.
After each group gavage every day, in addition to normal pressure blank group, other each group is placed in simulating raising in lower pressure environment, the
Within 3 days, press above-mentioned dosage gastric infusion, after being administered 60min, mice is placed in lower pressure environment in the 1000ml beaker filling water, negative
The lead of weight own body weight 5%, water temperature is room temperature, carries out swimming test.10 seconds can not emersion water with the whole submerged of head
Face is that power exhausts state, records each group and starts to power to exhaust the time of state as mice swimming time from swimming, takes in each group
Meansigma methods.
2. experimental result
Experimental result is as shown in table 1.
Table 1 low pressure mouse anti-reflecting fatigue Effect study experimental result
Note: compare with low pressure blank group, * P ＜ 0.05**P ＜ 0.01；
Compare with the present invention 1 group, △ P ＜ 0.05, △ △ P ＜ 0.01.
From experimental data statistical result, compared with low pressure blank group, the mice trip of each administration group and normal pressure blank group
The swimming time all has pole significance to improve (P ＜ 0.01)；The mice swimming time of emblic subgroup, Radix Astragali group and Fructus Lycii subgroup is the most notable
Less than the present invention 1 group (P ＜ 0.05)；The present invention 1 group there was no significant difference with the mice swimming time of the present invention 2 groups.
The present invention is not limited to above-mentioned embodiment, in the case of without departing substantially from the flesh and blood of the present invention, and this area skill
Art personnel it is contemplated that any deformation, improve, replace and each fall within the scope of the present invention.
Claims (10)
1. the Chinese medicine composition of a resisting fatigue, it is characterised in that described compositions is made up of the component including following crude drug:
Fructus Phyllanthi 20～50 weight portion, the Radix Astragali 20～50 weight portion and Fructus Lycii 10～30 weight portion.
Chinese medicine composition the most according to claim 1, it is characterised in that said composition is by the component including following crude drug
Make: Fructus Phyllanthi 25～45 weight portion, the Radix Astragali 30～45 weight portion and Fructus Lycii 15～30 weight portion.
Chinese medicine composition the most according to claim 1, it is characterised in that described compositions is by the group including following crude drug
Divide and make:
Fructus Phyllanthi 30 weight portion, the Radix Astragali 35 weight portion and Fructus Lycii 25 weight portion；Or
Fructus Phyllanthi 32.5 weight portion, the Radix Astragali 37.5 weight portion and Fructus Lycii 20 weight portion；Or
Fructus Phyllanthi 37.5 weight portion, the Radix Astragali 37.5 weight portion and Fructus Lycii 25 weight portion.
4. according to the Chinese medicine composition described in any one of claims 1 to 3, it is characterised in that described component only includes described
Crude drug.
5. according to the preparation method of the Chinese medicine composition described in any one of Claims 1 to 4, it is characterised in that described preparation
Method is selected from being pulverized and mixed method, water extraction method or ethanol water extraction method.
Preparation method the most according to claim 5, it is characterised in that described preparation method includes: by Fructus Phyllanthi, the Radix Astragali and
Fructus Lycii is pulverized, and mix homogeneously obtains described Chinese medicine composition.
Preparation method the most according to claim 5, it is characterised in that described preparation method comprises the steps:
(1) by Fructus Phyllanthi, the Radix Astragali and Fructus Lycii use water heating and refluxing extraction or supersound extraction 1～5 times, add based on emblic every time
Son, the Radix Astragali and the water of the 1 of Fructus Lycii gross weight～20 times amount, extract 0.5～5 hour every time, filters, and filtrate is merged；
(2) described filtrate is concentrated.
Preparation method the most according to claim 5, it is characterised in that described preparation method comprises the steps:
(1) Fructus Phyllanthi, the Radix Astragali and Fructus Lycii are heated to reflux or supersound extraction 1～5 times, add based on Fructus Phyllanthi, the Radix Astragali every time
With the ethanol water that concentration is 20～100vol% of 1～20 times amount of Fructus Lycii gross weight, extract 0.5～5 hour every time,
Filter, filtrate is merged；
(2) described filtrate is concentrated.
9. the Chinese medicine preparation of a resisting fatigue, it is characterised in that described Chinese medicine preparation comprises any one of Claims 1 to 4 institute
The Chinese medicine composition stated, and comprise pharmaceutically acceptable adjuvant.
10. the Chinese medicine composition described in any one of Claims 1 to 4 is for preparing prevention or the medicine of fatigue alleviating or health care food
The purposes of product.
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| CN111298020A (en) * | 2020-03-31 | 2020-06-19 | 刘敏如女科医系研究院(深圳)有限公司 | Traditional Chinese medicine composition with anti-fatigue effect and preparation method and application thereof |
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| CN102940733A (en) * | 2012-09-03 | 2013-02-27 | 吉林一正药业集团有限公司 | Composition for relieving physical fatigue and preparation method and application thereof |
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| CN109393283A (en) * | 2018-12-26 | 2019-03-01 | 同药集团大同制药有限公司 | Using Radix Astragali as the preparation method of the anti-Fatigue Composition of major ingredient |
| CN111298020A (en) * | 2020-03-31 | 2020-06-19 | 刘敏如女科医系研究院(深圳)有限公司 | Traditional Chinese medicine composition with anti-fatigue effect and preparation method and application thereof |
| CN111298020B (en) * | 2020-03-31 | 2021-12-17 | 刘敏如女科医系研究院(深圳)有限公司 | Traditional Chinese medicine composition with anti-fatigue effect and preparation method and application thereof |
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