CN106267458A - Flow regulator, fluid infusion device and manufacture method thereof - Google Patents
Flow regulator, fluid infusion device and manufacture method thereof Download PDFInfo
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- CN106267458A CN106267458A CN201510270538.9A CN201510270538A CN106267458A CN 106267458 A CN106267458 A CN 106267458A CN 201510270538 A CN201510270538 A CN 201510270538A CN 106267458 A CN106267458 A CN 106267458A
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Abstract
The invention provides in the fluid infusion device for patient is administered use flow regulator, with flow regulator for the fluid infusion device that patient is administered and their manufacture method.Wherein, flow regulator comprises the steps that the inlet duct connected for multiple fluid passages of conveyance fluid, the outlet conduit exported by the fluid in multiple fluid passages and the flow selection mechanism between the outlet and outlet conduit of multiple fluid passages with the entrance of multiple fluid passages, wherein, the flow that multiple fluid passages are configured to make to flow through the part or all of fluid passage in the plurality of fluid passage is different from each other, and flow selection mechanism is configured to select the segment fluid flow passage in multiple fluid passage to connect with outlet conduit.Implement said apparatus, equipment and method, it is possible to the flow of convection cell passage selects, it is thus achieved that multiple different flow selects.
Description
Technical field
The present invention relates to field of fluid, in particular to one for patient is administered
Fluid infusion device in the flow regulator that uses and with the fluid infusion of described flow regulator
Equipment and their manufacture method.
Background technology
Diabetes are a kind of metabolic diseases being characterized with hyperglycemia.Hyperglycemia is typically due to insulin and divides
Secrete defect or its biological agent is impaired, or both comprehensive functions cause.Long-term existence in diabetics body
Hyperglycemia can cause multiple organ (such as, eye, kidney, heart, blood vessel, nervous system etc.)
Chronic lesion, dysfunction.
Diabetes clinical diagnosis can be divided into type 1 diabetes and type 2 diabetes mellitus.Type 1 diabetes, also referred to as islets of langerhans
Element dependent diabetes, patient condition typically occurs in child or adolescent's period, is a kind of by congenital family
The disease of race's heredity.Type 1 diabetes belongs to a kind of autoimmune disease, and the immune system of health is to internal
The β cell producing insulin makes attack, ultimately results in and internal cannot produce insulin.This kind of patient needs
Want the blood sugar level in the islets of langerhans usually control volume of injection of exogenous.Type 1 diabetes patient is it is generally required to 24 is little
Time carrying electronic formula insulin pump in treatment, such as, Medtronic Minimed series insulin pump.2 type glycosurias
Disease, also referred to as non-insulin-dependent diabetes mellitus, general patient is adult, particularly obese people, its
Disease can cause becoming thin.The possible cause of disease includes: insulin resistant, makes health can not be efficiently used pancreas
Island element；The minimizing of insulin secretion, it is impossible to needed for meeting health.Type 2 diabetes mellitus patient in early days can be led to
Cross the mode of making the life better (such as, health diet, moderate exercise, safe fat-reducing, give up smoking and avoid second hand smoking
Deng) control, even cure diabetes.
The existing insulin pump being suitable for type 2 diabetes mellitus patient has electronic type and two kinds of insulin pumps of mechanical type,
Two kinds of insulin pumps are required for optimized integration amount injection simultaneously and two kinds of infusion of insulin sides of bolus quantities injection
Formula.For electronic type insulin pump, basic crack injection is advanced generally by step motor control screw mandrel,
Push directly on piston and carry out medicine conveying.And for mechanical insulin pump, basic crack injection is usually logical
Cross various means and reduce the fluid flow flowed out from medicine bag, realize continuous micro infusion by limiting flow.
But, conventional mechanical insulin pump generally only has the speed controlling of a kind of basic crack injection, it is impossible to full
Foot one day different periods of diabetics, or the demand that difference catering structure every day is to insulin intake.
Summary of the invention
For solving above-mentioned technical problem, the invention provides a kind of at the stream for patient is administered
In body infusion apparatus use flow regulator, with described flow regulator infusion apparatus and
Manufacture method, is configured to the flow of the segment fluid flow passage in multiple fluid passages or whole fluid passage
Different from each other, then the flow by being arranged between outlet and the outlet conduit of multiple fluid passage selects
Mechanism selects the segment fluid flow passage of multiple fluid passages to connect with outlet conduit, utilizes mechanical structure to obtain
Obtain multiple different flow to select.
First aspect according to embodiment of the present invention, it is provided that a kind of for patient is administered
The flow regulator used in fluid infusion device, this device comprises the steps that multiple fluid passage, is used for
Conveyance fluid and the segment fluid flow passage being configured to make to flow through in the plurality of fluid passage or all fluid
The flow of the fluid of passage is different from each other；Inlet duct, connects with the entrance of the plurality of fluid passage,
For described fluid is delivered to the plurality of fluid passage；Outlet conduit, for by the plurality of fluid
The fluid output of conveying in passage；Flow selection mechanism, be arranged in the outlet of the plurality of fluid passage with
Between described outlet conduit and be configured to select the segment fluid flow passage in the plurality of fluid passage and institute
State outlet conduit connection.
In some embodiments, the plurality of fluid passage may be disposed in single layer of chips.Chip is permissible
Being made up of the material of such as glass, resin or other macromolecular materials etc, the shape of chip can also be
Varied, such as, rectangle, square, circular etc..And, the fluid passage on chip can be passed through
The cutting mode such as (such as, cut etc.) or etching makes, and such as, is cut into the opening of groove-like
Formula passage.Certainly, fluid passage can also is that the enclosed channel embedding chip.The width of fluid passage
Or the degree of depth can be in the scope of 5 μm to 100 μm.Multiple fluid passages can be with various different on chip
Mode is arranged, and such as, the orthoscopic that multiple passages can be parallel on chip is arranged, multiple passages
Can also arrange in chip upper curve formula or coiling, be that concentric discs is around cloth with the center of chip for the center of circle
Put, arrange radially along radial direction for the center of circle with the center of chip, it is also possible to the center of chip with
Outer is some center of circle layout etc. radially.According to fluid passage arrangement on chip, can
Correspondingly to arrange entrance and exit position and the passage length etc. of multiple fluid passage.
In some embodiments, described flow selection mechanism comprises the steps that channel connection parts, described
In single layer of chips and be positioned on the outlet of the plurality of fluid passage, having can be by the plurality of fluid
Multiple selector channels that the outlet of passage connects with described outlet conduit respectively；Channel switching parts, with institute
State channel connection parts to engage, and be configured to selectively turn on or close described selector channel.
In some embodiments, the plurality of selector channel can be disposed on described channel connection parts
On multiple through holes, such as, the quantity of through hole can be equal with the quantity of selector channel.
In some embodiments, described channel switching parts comprise the steps that diaphragm seal, are covered in described logical
On multiple through holes of road communication means；Multiple select buttons are corresponding with the plurality of through hole and be positioned at institute
State on diaphragm seal, each in the plurality of select button have with on described channel connection parts
The protuberance of through hole coupling, and described protuberance is configured to engage with described through hole and leads to described to close
The connection of fluid passage corresponding to hole and described outlet conduit or can from the release of described through hole or depart from
Open the connection of the fluid passage corresponding with described through hole and described outlet conduit.
In some embodiments, described channel switching parts comprise the steps that diaphragm seal, are covered in described logical
On the through hole of road communication means；Select slide block, be positioned on described diaphragm seal, have and described passage
The protuberance of the through hole coupling in communication means, wherein, described selection slide block is configured to be pressed in described diaphragm seal
Upper slip is so that described protuberance can engage to close the fluid passage corresponding with described through hole with described through hole
Connection with described outlet conduit or can be from the release of described through hole or depart to open and described through hole pair
The fluid passage answered and the connection of described outlet conduit.
In some embodiments, the quantity of the protuberance of described selection slide block can be less than described fluid passage
Quantity.
In some embodiments, the plurality of fluid passage can be configured to outlet and is positioned at described single layer of chips
Circular surface circumference on.
In some embodiments, described flow selection mechanism comprises the steps that selection dish, covers described monolayer
The plurality of fluid passage on chip, has round-shaped, at the circle on a surface of circle selection dish
Have on week respectively with multiple through holes of the outlet of the plurality of fluid passage, diaphragm seal, be covered in
On described selection dish, select knob, be positioned on described diaphragm seal, have corresponding with described selection dish
Round-shaped, the circumference that circle selects knob has the protuberance mated with described through hole, described outlet
Pipeline runs through described diaphragm seal by described selection knob and the vented liquid with described selection dish connects, its
Described in select knob to be configured to rotate so that described protuberance is pressed into described logical together with described diaphragm seal
The fluid communication of hole outlet with described outlet conduit to close the fluid passage corresponding with described through hole, its
Described in the quantity of protuberance less than the quantity of described traffic channel.
In some embodiments, described selection knob can have storage described diaphragm seal, described selection dish
Recess with described chip.
In some embodiments, the plurality of fluid passage can be respectively arranged on multilayer chiop, such as,
Can arrange a fluid passage on one layer of chip, fluid passage can be with various different on chip
Mode is arranged.
In some embodiments, described multilayer chiop can be coated with on layer chip stacked together and each
Barrier film.
In some embodiments, described inlet duct can run through in one end of the multilayer chiop of described stacking
Described multilayer chiop connects with the entrance with the plurality of fluid passage with described barrier film.
In some embodiments, described flow selection mechanism comprises the steps that hollow penetrating member, described in
The cardinal extremity of empty penetrating member connects with described outlet conduit, and the sidewall of front end has opening；Select slide block,
Fix with the cardinal extremity of described hollow penetrating member, be configured to be slided so that described hollow penetrating member
Front-end selectivity pierce through the barrier film on described multilayer chiop so that described opening and the plurality of fluid lead to
A fluid passage connection in road.
In some embodiments, described hollow penetrating member can form as one with described outlet conduit,
Such as, the hollow penetrating member on the sidewall of front end with opening can either serve as outlet conduit, also can
Enough parts as flow selection mechanism.
In some embodiments, described chip is arranged the opposite side of fluid passage can have bellmouth,
Described inlet duct carries to the plurality of fluid passage with the state being stuck in described bellmouth through flexible ball
Fluid.
In some embodiments, in the plurality of fluid passage, the flow of fluid can be by the length of fluid passage
One or more in degree, shape of cross section or cross-sectional area determines.
In some embodiments, the plurality of fluid passage can be formed on chip by cutting or etching.
In some embodiments, described fluid can include insulin.
Second aspect according to embodiment of the present invention, it is provided that a kind of being used for flow regulator
The fluid infusion device being administered patient, this equipment comprises the steps that (such as, housing may be adapted to housing
It is worn on patient skin so that patient's portable use, or can be worn on belt, be placed in pocket)；
Reservoir, is positioned at described housing, for storing the fluid of infusion；Conveying assembly, is positioned at described housing
In and connect with described reservoir fluid, the fluid in described reservoir is delivered to injecting assembly；
Injecting assembly, is positioned at described housing and connects with described conveying assembly, for by described conveying assembly
The fluid of output connects with described Patient Fluid via the entry needle extended from described housing；Wherein, institute
State conveying assembly and include flow regulator recited above, the inlet duct of described flow regulator with
Described reservoir connects, and described outlet conduit connects with described injecting assembly.
The third aspect according to embodiment of the present invention, it is provided that a kind of for manufacturing for patient is entered
The method of the flow regulator used in the fluid infusion device that row is administered, the method comprises the steps that offer
For multiple fluid passages of conveyance fluid, wherein, the plurality of fluid passage is configured to make to flow through described
Segment fluid flow passage or the flow of the fluid of whole fluid passage in multiple fluid passages are different from each other；Carry
For the inlet duct for described fluid being delivered to the plurality of fluid passage, wherein, described inlet tube
Road connects with the entrance of the plurality of fluid passage；There is provided for by conveying in the plurality of fluid passage
The outlet conduit of fluid output；Arrange between outlet and described outlet conduit in the plurality of fluid passage
Flow selection mechanism, wherein, described flow selection mechanism is configured to select in the plurality of fluid passage
Segment fluid flow passage connects with described outlet conduit.
Fourth aspect according to embodiment of the present invention, it is provided that a kind of for manufacturing with Flow-rate adjustment dress
The method of the fluid infusion device for patient is administered put, the method comprises the steps that offer housing,
Providing a store for the reservoir of the fluid of infusion, wherein, described reservoir is positioned at described housing；Carry
The infusion assembly of injecting assembly, wherein, described conveying group it is delivered to for the fluid in described reservoir
Part is positioned at described housing and connects with described reservoir fluid；There is provided for by defeated for described conveying assembly
The injecting assembly that the fluid gone out connects with described Patient Fluid via the entry needle extended from described housing,
Wherein, described injecting assembly is positioned at described housing；Wherein, described conveying assembly includes above-mentioned flow
Adjusting means, the inlet duct of described flow regulator connects with described reservoir, described outlet conduit
Connect with described injecting assembly.
Said apparatus, equipment and the method that embodiment of the present invention provides, by by multiple fluid passages
Part or all of fluid passage in the flow of fluid be configured to different from each other and utilize flow selection mechanism
A part of fluid passage therein is selected to connect with outlet conduit, it is possible to obtain multiple different flow and select.
Accompanying drawing explanation
Fig. 1 is the conceptual schematic view of the flow regulator according to embodiment of the present invention；
Fig. 2 is the structural representation of the flow regulator according to first embodiment of the invention；
Fig. 3 is the decomposition view of the flow regulator shown in Fig. 2；
Fig. 4 is the schematic diagram of the fluid passage according to one embodiment of the present invention；
Fig. 5 a to Fig. 5 c is the slip schematic diagram selecting slide block according to one embodiment of the present invention；
Fig. 6 a is the structural representation of the flow regulator according to second embodiment of the invention；
Fig. 6 b is the stream used in the fluid infusion device for being administered patient shown in Fig. 6 a
Quantity regulating device is along the diametric sectional view of A-A '；
Fig. 7 is the flow used in the fluid infusion device for being administered patient shown in Fig. 6 a
The decomposition view of adjusting means；
Fig. 8 is the layout schematic diagram of the fluid passage according to second embodiment of the invention；
Fig. 9 a is the structural representation of the selection dish according to second embodiment of the invention；
Fig. 9 b is that the selection dish shown in Fig. 9 a is along the diametric sectional view of B-B '；
Figure 10 is the upward view selecting knob according to second embodiment of the invention；
Figure 11 is setting at the fluid infusion for being administered patient according to third embodiment of the invention
The structural representation of the flow regulator of standby middle use；
Figure 12 is the stream used in the fluid infusion device for being administered patient shown in Figure 11
The decomposition view of quantity regulating device；
Figure 13 is the stream used in the fluid infusion device for being administered patient shown in Figure 11
The sectional view of quantity regulating device；
Figure 14 is the layout schematic diagram of the fluid passage according to one embodiment of the present invention；
Figure 15 is the layout schematic diagram of the fluid passage according to one embodiment of the present invention；
Figure 16 be according to embodiment of the present invention with flow regulator for patient is administered
The schematic diagram of fluid infusion device；
Figure 17 be according to one embodiment of the present invention for manufacture at the stream for patient is administered
The method schematic diagram of the flow regulator used in body infusion apparatus；
Figure 18 be according to one embodiment of the present invention for manufacture with flow regulator for right
The method schematic diagram of the infusion apparatus that patient is administered.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearer, below in conjunction with accompanying drawing to this
Bright it is described in further detail.It should be noted that the present invention is not limited to parts structure shown in the drawings
Make and/or arrange, without departing from the case in the spirit of the invention, it is also possible to the various embodiment party to the present invention
Formula carries out various different combination.
Seeing Fig. 1, Fig. 1 is defeated at the fluid for being administered patient according to embodiment of the present invention
The conceptual schematic view of the flow regulator used in note equipment.Flow regulator 1 comprises the steps that multiple
Inlet duct 12 (such as, the thorn of hollow that fluid passage 11 connects with the entrance of the plurality of fluid passage
Wear parts etc.), by multiple fluid passages fluid export outlet conduit 13 (such as, the thorn of hollow
Wear parts etc.) and the flow choosing that is arranged between outlet and the outlet conduit 13 of multiple fluid passage 11
Select a good opportunity structure 14.Wherein, fluid can include the fluid media (medium) of such as insulin, analgesics etc, and flow is
Flowing through the Fluid Volume of the cross section of fluid passage in unit interval, Fluid Volume can calculate with volume.
When infusion fluid is insulin, the unit of flow can be unit/hour (unit/hour), wherein,
Unit/hour in unit and the substitution ratio of milliliter be 100:1, say, that 1 milliliter is 100 units.
Multiple fluid lines 11 entrance receive inlet duct 12 conveying fluid and fluid in each fluid passage
Middle circulation, and be configured to make to flow through the segment fluid flow passage of the plurality of fluid passage or all fluid lead to
The flow in road is different from each other.For example, it is possible to by multiple (such as, more than or equal to 2) fluid passage
Flow be configured to all differ, or can by the part in multiple fluid passages (such as, wherein
2,3,4 or more) be configured to different from each other.Flow selection mechanism 14 is arranged on many
Between outlet and the outlet conduit 13 of individual fluid passage 11, its entrance goes out with multiple fluid passage 11
Mouth fluid communication, outlet is in fluid communication with outlet conduit 13, is configurable to select multiple fluid passage
Segment fluid flow passage (fluid passage that such as, 1,2,3 or more flow differ) with
Outlet conduit is in fluid communication, thus obtains multiple different flow and select.
[the first embodiment]
Fig. 2 is setting at the fluid infusion for being administered patient according to first embodiment of the invention
The structural representation of the flow regulator of standby middle use；Fig. 3 be shown in Fig. 2 for patient is entered
The decomposition view of the flow regulator used in the fluid infusion device that row is administered.Flow regulator 100
Fluid passage 101, inlet duct 102, outlet conduit 103, channel connection parts 104, close can be included
Sealer 105 and select button 106.Wherein, multiple fluid passages 101 are to be arranged in rectangle in parallel
Single layer of chips 107 on, have embed chip groove-like structure, top be coated with cover plate 108 with will stream
Body passage 101 is closed with extraneous.Such as, chip 107 can be by such as glass, resin or other high scores
The material of sub-material etc is made, fluid passage 201 can by cutting (such as, cut) or
Etching mode is formed on chip 107.Multiple fluid passages 101 on chip 107 except using
Outside above-mentioned parallel form is arranged, it is also possible to use the form wriggled to arrange.Embodiments of the present invention
Multiple fluid passages arrangement form on chip is not defined.Fluid in each fluid passage 101
Flow can by the one in the length of fluid passage, cross-sectional area or shape of cross section, the two or
Three determines.Inlet duct 102 can pass through the through hole 1081 on cover plate 108 at fluid channel inlet end
The common fluid communication of multiple fluid passages 101 with on chip 107.
Channel connection parts 104 are bearing on chip 107 and are positioned on the outlet of fluid passage 101,
Such as, it is mountable to cover on the cover plate 108 of fluid passage 101, cover plate 108 has and fluid
The through hole 1082 of the positions and dimensions coupling that passage 101 respectively exports, channel connection parts 104 are via through hole
1082 connect with fluid passage 101.Channel connection parts 104 have going out fluid passage 101 respectively
Multiple through holes 1041 that mouth connects with outlet conduit 103, such as, the quantity of through hole 1041 and fluid passage
The quantity of 101 is equal.Through hole 1041 can select the cylindricality through hole of upper and lower surface equal diameters,
Can also select the through hole in that side of contact diaphragm seal 105 with bowl-like depression, such shape sets
Count and can strengthen sealing property further when select button closes through hole.Channel connection parts 104 also can set
Putting the recess 1042 all connected with multiple through holes 1041, outlet conduit 103 can pass through flexible block 109 (example
As, silica gel block) insert recess 1042, thus connect with through hole 1041 fluid on channel connection parts 104
Logical.
Diaphragm seal 105 (such as, pellosil) is covered on the through hole 1041 of channel connection parts 104,
The sealing closed can be strengthened when the through hole 1041 of select button 106 closing passage communication means 104.
Multiple select buttons 106 be arranged on diaphragm seal 105 and with the through hole 1041 of channel connection parts 104
Correspondence in quantity and position.Each button in multiple select buttons 106 can have and channel connection portion
The protuberance 1061 (such as, salient point) of through hole 1041 coupling of part 104, such as, size or vpg connection
Coupling.Such as, user and/or patient can press a select button 106 with by the protuberance 1031 of this button
It is pressed into through hole 1041 corresponding with this protuberance on channel connection parts 104 together with diaphragm seal 105, from
And close the fluid passage 101 of this through hole 1041 correspondence and the fluid communication of outlet conduit 103.Such as,
User can also lift a button in multiple select button 106 with by the protuberance 1061 of this button from this
The through hole 1041 that protuberance is corresponding discharges or makes protuberance 1061 depart from from the through hole 1041 that this protuberance is corresponding,
Thus the fluid passage 101 of this through hole 1041 correspondence is turned on outlet conduit 103.It is to say, use
Family is by selecting the different select button of pressing can obtain multiple different flow, and flow selects operation letter
Single, quick, it is simple to user uses under several scenes (such as, outdoor activity scene etc.).
The flow summation that flow is multiple fluid passages on X and chip in the fluid passage closed is Y
When, the button corresponding by this fluid passage on pressing select button carrys out closing passage communication means
The through hole that this fluid passage upper is corresponding, can obtain the flow of (Y-X) at outlet conduit.Due on chip
The flow of multiple fluid passages is different from each other, say, that the value of X is variable, then logical
Cross and select different buttons (fluid passages that corresponding closedown is different) can obtain different at select button
Flow.By select button open a fluid passage connect with outlet conduit when, can obtain
The flow that flow is this fluid passage opened.
Flow for fluid passage a part of in multiple fluid passages is different from each other, and remainder fluid leads to
The situation that road flow is identical, that portion that on channel connection parts, the quantity of through hole can be different from each other with flow
The quantity of shunting body passage is identical, corresponding select button may select the passage closed or open be flow that
These those different fluid passages.
[deformation of the first embodiment]
Mode except selecting diaphragm seal to coordinate with multiple select buttons realizes through hole on channel connection parts
Switch, it is also possible to use diaphragm seal with selection slide block mode realize.For diaphragm seal and selection slide block
Embodiment, diaphragm seal is covered on the through hole of channel connection parts, select slide block be positioned at diaphragm seal
On, there is the protuberance mated with the through hole on channel connection parts, and can be configured to be pressed in sealing
Slide on film so that protuberance is pressed into the through hole on channel connection parts together with diaphragm seal, thus close this and lead to
The fluid communication of fluid passage corresponding to hole and outlet conduit, it is also possible to be configured to protuberance from channel connection
Release in through hole on parts is so that fluid passage corresponding to this through hole connects with outlet conduit.
Select slide block can have one or more protuberance (such as, salient point) on the surface of contact diaphragm seal,
Can be slided selection slide block by user and/or patient by the way of sliding shoe or sliding bar, so that thereon
Protuberance is pressed into different through holes together with diaphragm seal, and selectivity is closed fluid corresponding to different through holes and led to
Road and the fluid communication of outlet conduit, or, or remove to open and this through hole from through hole release by protuberance
Corresponding fluid passage and the connection of outlet conduit.
When being connected with unlatching from through hole release by protuberance, selectable flow is opened
Or the flow sum of passage corresponding to multiple through hole.For protuberance being pressed into the through hole situation with closedown connection,
When on selection slide block, the quantity of salient point is 1, obtainable flow is chosen as multiple fluid passages on chip
Flow summation deduct the flow of 1 fluid passage selecting to close.Selecting the quantity of salient point on slide block is 2
Time, obtainable flow is chosen as the flow summation of multiple fluid passages on chip and deducts select to close 2
The flow of individual fluid passage.When the salient point of selection slide block is other quantity, by that analogy.Preferably, choosing
Select the quantity quantity less than fluid passage of slide block upper convex portion, such as, few 1.At other embodiments
In, select fewer than the quantity of fluid passage 2 of the quantity of slide block upper convex portion, or 3, etc..
Fig. 4 is the schematic diagram of the fluid passage according to one embodiment of the present invention.Fig. 5 a to Fig. 5 c is root
The slip schematic diagram selecting slide block according to one embodiment of the present invention.As shown in Figure 4, with insulin
As a example by conveying, 3 fluid passages 401,402 and 403, the flow of the fluid flow through inside them is respectively
It is 40 units/sky, 20 units/sky, 20 units/sky.Shown in as shown in Figure 5 a to 5 c, select the convex of slide block
Point is 2, fewer than the quantity of fluid passage 1, selects slide block when shown in Fig. 5 a, selects
Slide block closes the through hole on the channel connection parts of passage 401 and 402 correspondence, passage 403 and outlet
Pipeline communication, obtainable flow is 20 units/sky；Slide block is selected to slide down to figure along the direction of diagram
State shown in 5b, selects slide block to close leading on the channel connection parts of passage 402 and 403 correspondence
Hole, passage 401 connects with outlet conduit, and obtainable flow is 40 units/sky；Select slide block along diagram
Direction slide down to the state shown in Fig. 5 c, select slide block to close the passage of passage 403 correspondence even
Through hole on logical parts, passage 401 connects with outlet conduit with 402, and obtainable flow is (40+20)
Unit/sky.
[the second embodiment]
In the embodiment shown in Fig. 2 and Fig. 3, chip has the surface of rectangle, multiple fluid passage
In the square surface of chip, orthoscopic is arranged in parallel, and chip can also have various difform surface
(such as, circular etc.) and fluid passage can also use diversified layout (such as, spiral,
Radial radiation layout etc.).
Fig. 6 a is setting at the fluid infusion for being administered patient according to second embodiment of the invention
The structural representation of the flow regulator of standby middle use；Fig. 6 b be shown in Fig. 6 a for patient
The flow regulator used in the fluid infusion device being administered is along the diametric sectional view of A-A '；
Fig. 7 is the Flow-rate adjustment used in the fluid infusion device for being administered patient shown in Fig. 6 a
The decomposition view of device；Fig. 8 is the layout schematic diagram of the fluid passage according to second embodiment of the invention；
Fig. 9 a is the structural representation of the selection dish according to second embodiment of the invention；Fig. 9 b is shown in Fig. 9 a
Selection dish along the diametric sectional view of B-B '；Figure 10 is the selection according to second embodiment of the invention
The upward view of knob.
As shown in Fig. 6 to Figure 10, flow regulator 200 can include fluid passage 201, inlet duct
202, outlet conduit 203, selection dish 204, diaphragm seal 205, selection knob 206.Fig. 8 shows stream
The arrangement of body passage, multiple fluid passages 201 on the chip 207 have circular surface with circle
The center of circle on surface is that concentric circles is arranged, the common entrance in multiple fluid passages 201 is arranged on circular surface
The center of circle, four outlets are respectively provided with circumferentially, spaced 90 degree.Can be according to fluid passage dish
Around length or channel cross-sectional area limit inner fluid passage flow.Fluid passage on chip except use
Outside mode shown in Fig. 8 is arranged, it is also possible to adopt layout in other ways, such as, fluid passage is common
Same entrance may be disposed at the position in the deviation circular surface center of circle, and each outlet is arranged on circumference, along this position
Put curvilinear layout fluid passage (such as, shown in Figure 14), or along the center of circle to each outlet radial direction in
Radial layout fluid passage (such as, as shown in figure 15).
On chip 207, the opposite side of layout fluid passage 201 (is core from the point of view of the direction shown in Fig. 6 b
The lower section of sheet 207) bellmouth 2071, inlet duct 202 (such as, the penetrating member of hollow) can be set
Can be stuck in bellmouth 2071 through flexible ball 208 (such as, silica-gel sphere), insert fluid passage 201
Common entrance, to multiple fluid passages 201 conveyance fluid.By flexible ball 208 and bellmouth 2071
Laminating can strengthen sealing.
Selection dish 204 has corresponding with circular chip 207 round-shaped, covers circular chip 207
Multiple fluid passages 201.The circumference of selection dish 204 circular surface has and is arranged on circular chip 207 circle
Multiple through holes 2041 of the outlet of each fluid passage 201 on week.As shown in figures 9 a and 9b,
Through hole 2041 can be the through hole at upper surface with bowl-like depression.In other embodiments, through hole can
To be the cylindrical hole of upper and lower surface equal diameters.
It is coated with diaphragm seal 205 on selection dish 204, is to select knob 206 on diaphragm seal 205.Choosing
Select knob 206 and there is the circular surface corresponding with selection dish 204, the circumference of this circular surface has with
The protuberance 2061 of through hole 2041 coupling of selection dish 204, such as, positions and dimensions is designed to block
The salient point of the through hole shown in Fig. 9 a and Fig. 9 b.The home position selecting the circular surface of knob 206 also has
There are the through hole 2062 allowing outlet conduit 203 (such as, the penetrating member of hollow) to pass in and out, outlet conduit
203 can run through diaphragm seal 205 via through hole 2062, with through hole 2041 fluid on selection dish 204 even
Logical.Such as, outlet conduit 203 can be inserted into the circle centre position being positioned at selection dish 204 and each with on circumference
Through hole 2041 all connects the recess 2042 of (such as, can be connected) by the mode such as groove or pipeline, thus
Make the fluid passage connection that outlet conduit 203 is corresponding with through hole 2041 on selection dish 204.
Select position and through hole 2041 position circumferentially on selection dish 204 of the protuberance 25 of knob 206
Put correspondence and size can blocking via hole 2041.Knob 206 is selected to be configured to be rotated to drive it
On protuberance 2061 circumferentially move, select protuberance 2061 together with close by the radian that circumferentially rotates
Sealer 205 is pressed into the one or more through holes 22 on selection dish 204 together, thus it is right to close through hole 2041
The outlet of the fluid passage answered and the fluid communication of outlet conduit 203.Wherein, knob 206 epirelief is selected
The number (such as, the protuberance number shown in Fig. 9 is 3) in portion 2061 can be less than the number of fluid passage
(such as, the fluid passage number shown in Fig. 8 is 4).It that case, can obtain at outlet conduit
Flow corresponding to fluid passage that flow is connection.By knob will be selected to rotate different radian, optional
Select the through hole that the fluid passage being intended to close is corresponding on selection dish, thus obtain different flows and select.
In the flow regulator 200 shown in Fig. 6 b, select knob 206 to have and can receive diaphragm seal
205, the recess 2063 of selection dish 204 and chip 207.The basal surface of recess 2063 is and selection dish 204
The circular surface corresponding with chip 207 size, at the protuberance provided circumferentially about 2061 of this circular surface.Choosing
The recess arrangement selecting knob 206 can reduce the overall dimensions of flow regulator, allows whole device more step up
Gather, also allow for device miniaturization.But, in other embodiments, selection knob may be designed as not to be had
There are storage diaphragm seal, selection dish or a recess of chip, but are directly mounted at the profile on diaphragm seal and are
Cylindrical knob.
[the 3rd embodiment]
As it was previously stated, multiple fluid passages may be disposed in single layer of chips, it is possible to be arranged at multilayer laminated
On chip.Such as, multiple fluid passages can be respectively arranged on multilayer chiop, can set on one layer of chip
Putting a fluid passage, the fluid passage on every layer of chip can be to passage length, cross-sectional area or transversal
One in the shape of face, the two or three are configured.Additionally, fluid passage can be to cut on chip
Cut or etch the groove of formation, it is also possible to be the tube shaped embedding chip.For the passage of form of grooves,
Multilayer chiop can cover barrier film (such as, pellosil etc.) on chip stacked together and each, thus
Block the fluid in passage to flow out.Inlet duct can the multilayer chiop of stacking one end (such as, with enter
One end that mouthful pipeline is corresponding) run through the barrier film on multilayer chiop and chip, thus with on each layer chip
The entrance connection of each fluid passage.
Figure 11 is setting at the fluid infusion for being administered patient according to third embodiment of the invention
The structural representation of the flow regulator of standby middle use；Figure 12 be shown in Figure 11 for patient
The decomposition view of the flow regulator used in the fluid infusion device being administered；Figure 13 is Figure 11
The section view of the shown flow regulator used in the fluid infusion device for patient is administered
Figure.Flow regulator 300 shown in Figure 11 can include multiple fluid passage 301 (being illustrated as 3),
Inlet duct 302 (such as, the penetrating member of hollow), outlet conduit 303 and selection slide block 304.3
Individual fluid circulation 301 is separately positioned on 3 layers of chip 305, and these 3 layers of chips can form a chipset.
Fluid passage 301 is form of grooves passage at chip 305, is also covered with barrier film 306 on chip 305,
For example, it may be pellosil etc., the fluid in block fluid passage 301 is flowed out by chip 305.Enter
Mouth pipeline 302 can run through each layer chip 305 and barrier film thereon at the arrival end of fluid passage 301
306, to fluid passage conveyance fluid.For example, it is possible on barrier film 306 with the entrance of fluid passage 301
Corresponding position arranges the hole more slightly larger than the entrance hole diameter of fluid passage 301, and fluid can via this some holes certainly
By the fluid passage flowing into each layer.Cover plate 307 can also be covered on the superiors' barrier film 306 of chipset,
Cover plate 307 has through hole 3071, exit passageway 303 in the outlet side of the fluid passage 301 of chipset
Chipset can be inserted via the through hole 3071 on cover plate 307, thus flow with each fluid passage of chipset
Body connects.
Can have opening on the sidewall of outlet conduit 303 (such as, the penetrating member of hollow) front end, select
Slide block 304 can be fixed with the cardinal extremity of outlet conduit 303, and be configured to be slided so that
The front-end selectivity of outlet conduit 303 pierces through the barrier film 306 on multilayer chiop, so that outlet conduit 303
The opening of front end connects with a fluid passage in multiple fluid passages.Fluid passage due to each layer
Flow is different, and the selection slide block 304 that slides controls outlet conduit 303 and pierces through the chipset of stacking, makes front end
Opening connect with the fluid passage in chipset one layer of chip, can obtain this layer of chip fluid lead to
The flow that road is corresponding.Such as, in the embodiment shown in Figure 13, outlet conduit 303 inserts chipset
The fluid passage of the superiors, then the flow that the fluid passage of the superiors' chip is corresponding can be obtained.
In the above-described embodiment, selecting slide block is to coordinate with outlet conduit to realize flow selection.At other
In some embodiments, it is also possible to realize flow by selecting slide block and single hollow penetrating member to coordinate
Selecting, in such embodiment, outlet conduit can be to be not designed to the penetrating member form of hollow.
The cardinal extremity of hollow penetrating member (such as, the pin of hollow) can connect with outlet conduit, the sidewall of front end
On be designed with opening.Hollow can be made by the selection slide block that the cardinal extremity slided with hollow penetrating member is fixed
The penetrating member front end outlet side selectivity in fluid passage pierces through the barrier film of multilayer chiop, so that front
Opening on the wall of side and the outlet of the fluid passage of one layer of chip in multilayer chiop, it is thus achieved that this fluid
The flow that passage is corresponding.
Embodiment of the present invention additionally provide a kind of with flow regulator for patient is administered
Fluid infusion device, this fluid infusion device can include housing, and such as, housing may be adapted to be worn on trouble
Person's skin is so that patient's portable use, or can be worn on belt, be placed in pocket；It is positioned at housing
In and for storing the reservoir of fluid of infusion；It is positioned at housing and the fluid with reservoir connects
Logical conveying assembly, conveying assembly is for being delivered to injecting assembly by the fluid in reservoir；It is positioned at housing
In and with conveying assembly fluid communication injecting assembly, for by conveying assembly export fluid via from
The entry needle that housing extends connects with Patient Fluid.Wherein, infusion assembly can include having the most
Planting the flow regulator that embodiment describes, wherein, the inlet duct of flow regulator can be with storage
Liquid device connects, and outlet conduit is in fluid communication with injecting assembly.Figure 16 is the band according to embodiment of the present invention
There is the schematic diagram of the fluid infusion device for patient is administered of flow regulator.Fluid infusion
Equipment 400 can include that select button 402 that shell 401, opening from shell 401 extend is (such as,
Can be the select button 106 in flow regulator 100).Reservoir, defeated can be received in housing 401
Sending component and injecting assembly etc., wherein, the surface of housing 401 can have transparent form 403, and it is permissible
Allow user to check the memory state of fluid in reservoir through shell 401, facilitate user to understand storage in time
The conveying condition of fluid in liquid device；Conveying assembly can include for the assembly of basic crack injection with for pill
The assembly of amount injection, correspondingly, can arrange at housing 401 and control the injection button 404 that bolus quantities is injected
With SR 405；Injecting assembly can include the entry needle that can connect with Patient Fluid, and this entry needle can
Control by being arranged at the entry needle firing button 406 of housing 401.Additionally, housing 401 also can be arranged
Start pin 407, for controlling the startup of fluid infusion device 400.The fluid that embodiment of the present invention provides
Infusion apparatus has flow and selects function, can pass through select button, selects slide block or select the machineries such as knob
Mode selects different flow quickly and easily.When infusion fluid is insulin, can facilitate
User and/or patient according to one day different periods or difference catering structure every day quickly to infusion of insulin
Flow selects.And, the above-mentioned flow infusion apparatus of the present invention can by mechanical mechanism be only
Various flow rate selection can be carried out, compared with electronic type infusion apparatus power-actuated with needs, it is possible to significantly drop
The manufacturing cost of low infusion apparatus.
Embodiment of the present invention additionally provides a kind of defeated at the fluid for being administered patient for manufacturing
The method of the flow regulator used in note equipment.Figure 17 is the use according to one embodiment of the present invention
In the method manufacturing the flow regulator used in the fluid infusion device for patient is administered
Schematic diagram, the method comprises the steps that step S101, it is provided that for multiple fluid passages of conveyance fluid, its
In, segment fluid flow passage that these fluid passages can be configured to make to flow through in these fluid passages or all flow
The flow of the fluid of body passage is different from each other；Step S102, it is provided that be used for delivering the fluid to multiple fluid
The inlet duct of passage, wherein, inlet duct connects with the entrance of multiple fluid passages；Step S103,
There is provided for the outlet conduit by the fluid output of conveying in multiple fluid passages；Step S104, multiple
Arranging flow selection mechanism between outlet and the outlet conduit of fluid passage, wherein, flow selection mechanism is joined
It is set to select the segment fluid flow passage in multiple fluid passage to connect with outlet conduit.
Embodiments of the present invention additionally provide a kind of for manufacturing with the stream for being administered patient
The method of the fluid infusion device of quantity regulating device.Figure 18 be according to one embodiment of the present invention for
Manufacture the method signal of the fluid infusion device for patient is administered with flow regulator
Figure, the method comprises the steps that step S201, it is provided that housing, step S202, it is provided that for storing infusion
The reservoir of fluid, wherein, reservoir is positioned at housing；Step S203, it is provided that for by reservoir
Fluid be delivered to the infusion assembly of injecting assembly, wherein, conveying assembly is positioned at housing and and liquid storage
Device is in fluid communication；Step S204, it is provided that for the fluid that conveying assembly exports is extended via from housing
The injecting assembly that connects with Patient Fluid of entry needle, wherein, injecting assembly is positioned at housing.Wherein,
Conveying assembly can include the flow regulator of above-mentioned various embodiment, wherein, flow regulator
Inlet duct connects with reservoir, and outlet conduit is in fluid communication with injecting assembly.
Although it should be pointed out that, each side of said apparatus, equipment and method etc. is in a specific sequence
Arrange with specific structure and be described, but this is only used for illustrating, and the present invention does not constitute restriction,
Claimed theme is not limited to described order and structure is arranged.Those skilled in the art should manage
Solve, without departing from essence of the present invention when, can to invention, various modification can be adapted, and can enter
Row equivalent.Therefore, the theme that the present invention is claimed is not limited to disclosed above being embodied as
Mode, may also include all technical schemes falling into claims and the technology being equal to therewith
Scheme.Additionally, in the claims, except as otherwise noted, all of term should by broadest reasonably
The meaning understands.
Claims (22)
1. the flow regulator used in the fluid infusion device for patient is administered,
It is characterized in that, including:
Multiple fluid passages, for conveyance fluid, and are configured to make to flow through in the plurality of fluid passage
Segment fluid flow passage or the flow of whole fluids of fluid passage different from each other；
Inlet duct, connects with the entrance of the plurality of fluid passage, is used for delivering the fluid to described many
Individual fluid passage；
Outlet conduit, for by the fluid output of conveying in the plurality of fluid passage；
Flow selection mechanism, is arranged between the outlet of the plurality of fluid passage and described outlet conduit,
And it is configured to select the segment fluid flow passage in the plurality of fluid passage to connect with described outlet conduit.
Device the most according to claim 1, it is characterised in that the plurality of fluid passage is arranged at
In single layer of chips.
Device the most according to claim 2, it is characterised in that described flow selection mechanism includes:
Channel connection parts, in described single layer of chips and be positioned on the outlet of the plurality of fluid passage,
Have and multiple selections that the outlet of the plurality of fluid passage connects with described outlet conduit respectively can be led to
Road；
Channel switching parts, engage with described channel connection parts, and are configured to optionally
It is turned on and off described selector channel.
Device the most according to claim 3, it is characterised in that the plurality of selector channel is configuration
Multiple through holes on described channel connection parts.
Device the most according to claim 4, it is characterised in that described channel switching parts include:
Diaphragm seal, is covered on multiple through holes of described channel connection parts；
Multiple select buttons, corresponding with the plurality of through hole and be positioned on described diaphragm seal, the plurality of
Each in select button has the protuberance mated with the through hole on described channel connection parts, and joins
It is set to engage to close the fluid passage corresponding with described through hole and described outlet conduit with described through hole
Connection or can from the release of described through hole with open the fluid passage corresponding with described through hole with described go out
The connection of mouth pipeline.
Device the most according to claim 4, it is characterised in that described channel switching parts include:
Diaphragm seal, is covered on the through hole of described channel connection parts；
Select slide block, be positioned on described diaphragm seal, have and the through hole on described channel connection parts
The protuberance joined, wherein, described selection slide block is configured to be pressed on described diaphragm seal slip so that described protuberance
Can engage to close the company of the fluid passage corresponding with described through hole and described outlet conduit with described through hole
Lead to or can discharge to open the fluid passage corresponding with described through hole and described outlet from described through hole
The connection in road.
Device the most according to claim 6, it is characterised in that the number of the protuberance of described selection slide block
Amount is less than the quantity of described fluid passage.
Device the most according to claim 2, the plurality of fluid passage is configured to outlet and is positioned at described
On the circumference of the circular surface of single layer of chips.
Device the most according to claim 8, it is characterised in that described flow selection mechanism includes:
Selection dish, covers the plurality of fluid passage in described single layer of chips, has round-shaped,
Have on the circumference on one surface of circular selection dish respectively with the outlet of the plurality of fluid passage
Multiple through holes,
Diaphragm seal, is covered on described selection dish,
Select knob, be positioned on described diaphragm seal, have corresponding with described selection dish round-shaped,
The circumference that circle selects knob have the protuberance mated with the through hole on described selection dish, described outlet
Pipeline runs through described diaphragm seal by described selection knob and the vented liquid with described selection dish connects,
Wherein, described selection knob is configured to rotate so that described protuberance is pressed together with described diaphragm seal
Enter described through hole thus close the fluid of the fluid passage corresponding with described through hole and described outlet conduit even
Logical, the quantity of described protuberance is less than the quantity of described fluid passage.
Device the most according to claim 9, it is characterised in that described selection knob has storage institute
State diaphragm seal, described selection dish and the recess of described chip.
11. devices according to claim 1, it is characterised in that the plurality of fluid passage sets respectively
It is placed on multilayer chiop.
12. devices according to claim 11, it is characterised in that described multilayer chiop is layered in one
Rise and be coated with barrier film on each layer chip.
13. devices according to claim 12, it is characterised in that described inlet duct is at described layer
One end of folded multilayer chiop run through described multilayer chiop and described barrier film with the plurality of fluid passage
Entrance connects.
14. devices according to claim 13, it is characterised in that described flow selection mechanism includes:
Hollow penetrating member, the cardinal extremity of described hollow penetrating member connects with described outlet conduit, front end
There is on sidewall opening；
Select slide block, fix with the cardinal extremity of described hollow penetrating member, be configured to be slided so that institute
State hollow penetrating member front-end selectivity pierce through the barrier film on described multilayer chiop so that described opening with
A fluid passage connection in the plurality of fluid passage.
15. devices according to claim 14, it is characterised in that described hollow penetrating member and institute
State outlet conduit to form as one.
16. according to Claim 8 to the device described in any one in 10, it is characterised in that described chip
The opposite side of upper layout fluid passage has bellmouth, and described inlet duct is to be stuck in institute through flexible ball
State the state of bellmouth to the plurality of fluid passage conveyance fluid.
17. according to the device described in any one in claim 1 to 15, it is characterised in that the plurality of
In fluid passage, the flow of fluid is by the length of fluid passage, shape of cross section or cross-sectional area
Person or many persons determine.
18. according to the device described in any one in claim 2 to 15, it is characterised in that the plurality of
Fluid passage is formed on chip by cutting or etching.
19. according to the device described in any one in claim 1 to 15, it is characterised in that described fluid
Including insulin.
20. 1 kinds of fluid infusion device being used for patient is administered with flow regulator, its
It is characterised by, including:
Housing；
Reservoir, is positioned at described housing, for storing the fluid of infusion；
Conveying assembly, is positioned at described housing and connects with described reservoir fluid, for by described storage
Fluid in liquid device is delivered to injecting assembly；
Injecting assembly, is positioned at described housing and connects with described conveying assembly, for by described conveying
The fluid of assembly output connects with described Patient Fluid via the entry needle extended from described housing；
Wherein, described conveying assembly includes the flow regulator described in claim 1 to 19 any one,
The inlet duct of described flow regulator connects with described reservoir, described outlet conduit and described injection
Assembly connects.
21. 1 kinds for manufacturing the flow used in the fluid infusion device for being administered patient
The method of adjusting means, it is characterised in that including:
Thering is provided the multiple fluid passages for conveyance fluid, wherein, the plurality of fluid passage is configured to make
Flow through the flow of fluid of the segment fluid flow passage in the plurality of fluid passage or whole fluid passage each other
Different；
Inlet duct for delivering the fluid to the plurality of fluid passage, wherein, described entrance are provided
Pipeline connects with the entrance of the plurality of fluid passage；
There is provided for the outlet conduit by the fluid output of conveying in the plurality of fluid passage；
Between outlet and described outlet conduit in the plurality of fluid passage, flow selection mechanism is set, its
In, described flow selection mechanism is configured to select the segment fluid flow passage in the plurality of fluid passage and institute
State outlet conduit connection.
22. 1 kinds for manufacturing the fluid infusion being used for being administered patient with flow regulator
The method of equipment, it is characterised in that including:
Housing is provided,
Providing a store for the reservoir of the fluid of infusion, wherein, described reservoir is positioned at described housing；
The fluid in described reservoir is provided to be delivered to the infusion assembly of injecting assembly, wherein, described
Conveying assembly is positioned at described housing and connects with described reservoir fluid；
There is provided for fluid that described conveying assembly is exported via the entry needle extended from described housing with
The injecting assembly of described Patient Fluid connection, wherein, described injecting assembly is positioned at described housing；
Wherein, described conveying assembly includes the flow regulator described in claim 1 to 19 any one,
The inlet duct of described flow regulator connects with described reservoir, described outlet conduit and described injection
Assembly connects.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510270538.9A CN106267458A (en) | 2015-05-25 | 2015-05-25 | Flow regulator, fluid infusion device and manufacture method thereof |
| PCT/CN2016/083282 WO2016188425A1 (en) | 2015-05-25 | 2016-05-25 | Flow regulating device, fluid infusion apparatus, and manufacturing method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510270538.9A CN106267458A (en) | 2015-05-25 | 2015-05-25 | Flow regulator, fluid infusion device and manufacture method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106267458A true CN106267458A (en) | 2017-01-04 |
Family
ID=57393776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510270538.9A Pending CN106267458A (en) | 2015-05-25 | 2015-05-25 | Flow regulator, fluid infusion device and manufacture method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN106267458A (en) |
| WO (1) | WO2016188425A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112723477A (en) * | 2020-12-25 | 2021-04-30 | 珠海格力电器股份有限公司 | Diversion structure, soft water system and regeneration method |
| CN112794407A (en) * | 2020-12-25 | 2021-05-14 | 珠海格力电器股份有限公司 | Flow guide part, softening system and regeneration recovery method |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230123308A1 (en) * | 2021-10-15 | 2023-04-20 | Repro-Med Systems, Inc. | System and method for configurable flow controller |
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| WO2016188425A1 (en) | 2016-12-01 |
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