CN106266947A - 用于治疗骨质增生的药物 - Google Patents

用于治疗骨质增生的药物 Download PDF

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CN106266947A
CN106266947A CN201610752577.7A CN201610752577A CN106266947A CN 106266947 A CN106266947 A CN 106266947A CN 201610752577 A CN201610752577 A CN 201610752577A CN 106266947 A CN106266947 A CN 106266947A
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黄佩丽
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Abstract

本发明公开了一种用于治疗骨质增生的药物，由下述重量份配比的原料制成：桃仁8‑12份、红花3‑7份、知母8‑12份、杜仲12‑18份、川芎3‑7份、赤芍8‑12份、鳖甲10‑15份、莪术8‑12份、鸡血藤12‑18份、丹参12‑18份、穿山甲8‑12份、威灵仙12‑18份、淫羊藿12‑18份、巴戟天12‑18份、甘草3‑7份，丝瓜络4‑8份、乳香3‑7份、没药3‑7份、钩藤8‑12份、黄柏8‑12份。本发明药物选取20种天然中药科学配伍，配方简单，各原料药协同作用起到化瘀驱邪、舒筋通络的效果，见效快，标本兼治，无毒副作用，而且其制备方法简单、服用方便，成本低。有效率达95.6％以上。

Description

用于治疗骨质增生的药物
技术领域
本发明涉及中药，具体是一种用于治疗骨质增生的药物。
背景技术
骨质增生症多发于中年以上。一般认为由于中年以后体质虚弱及退行性变；长期站立或行走及长时间的持于某种姿势，由于肌肉的牵拉或撕脱、出血，血肿机化，形成刺状或唇样的骨质增生；骨刺对软组织产生机械性的刺激和外伤后软组织损伤、出血、肿胀而致。骨质增生症属中医的"痹证"范畴，亦称"骨痹"。中医认为本病与外伤、劳损、瘀血阻络、感受风寒湿邪、痰湿内阻、肝肾亏虚等有关。由于骨质增生可发生于全身各部，临床表现也就错综复杂，但治则总以补肾健骨、扶正祛邪、活血化瘀、软坚消肿、疏通经络等法为要。
目前，骨质增生的发病率较高，治疗也有多种方式，以药物治疗为主，治疗骨质增生的西药，效果不理想，且有一定的副作用，中药方面则较少，多以一些传统经方辩证治疗，效果也不甚理想。
发明内容
本发明的目的是提供一种疗效好、成本低、无毒副作用的治疗骨质增生的药物。
实现本发明目的的技术方案是：
一种用于治疗骨质增生的药物，由下述重量份配比的原料制成：
桃仁8-12份、红花3-7份、知母8-12份、杜仲12-18份、川芎3-7份、赤芍8-12份、鳖甲10-15份、莪术8-12份、鸡血藤12-18份、丹参12-18份、穿山甲8-12份、威灵仙12-18份、淫羊藿12-18份、巴戟天12-18份、甘草3-7份，丝瓜络4-8份、乳香3-7份、没药3-7份、钩藤8-12份、黄柏8-12份。
上述用于治疗骨质增生的药物，各原料的最佳重量份配比为：
桃仁10份、红花5份、知母10份、杜仲15份、川芎5份、赤芍10份、鳖甲12份、莪术10份、鸡血藤15份、丹参15份、穿山甲10份、威灵仙15份、淫羊藿15份、巴戟天15份、甘草5份，丝瓜络6份、乳香5份、没药5份、钩藤10份、黄柏10份。
所述的原料药材在中药店及市场有售。
本发明药物的制备方法如下：
(1)按重量份配比称取各原料药，将全部原料药粉碎成粗粉，一起混合置于容器中，加入原料量3-5倍浓度为50-60％的乙醇浸渍4-6天后，过滤去渣，滤液减压回收乙醇至无醇味，得浓缩液80-100份，备用；
(2)在步骤(1)制得的浓缩液中加入900-1000份水和0.6-1份山梨酸钾，搅匀、静置20-30h，过滤，得滤液，备用；
(3)另用80-100份蔗糖，加100-120份水煮沸40-50min，过滤，备用；
(4)将步骤(2)和(3)的滤液混合置于容器内，加800-1000份水，冷却后装瓶、密封后进行灭菌处理，制成产品。
本发明中，各原料药的药理、功效如下：
桃仁：具有活血祛瘀，润肠通便，止咳平喘的功效。用于经闭痛经，瘕瘕痞块，肺痈肠痈，跌扑损伤，肠燥便秘，咳嗽气喘。
红花：具有活血通经，散瘀止痛之功效。用于经闭，痛经，恶露不行，症瘕痞块，胸痹心痛，瘀滞腹痛，胸胁刺痛，跌扑损伤，疮疡肿痛。
知母：清热泻火，滋阴润燥。热病烦渴，肺热燥咳，骨蒸潮热，内热消渴，肠燥便秘。
杜仲：有补益肝肾、强筋壮骨、调理冲任、固经安胎的功效。可治疗肾阳虚引起的腰腿痛或酸软无力，肝气虚引起的胞胎不固，阴囊湿痒等症。
川芎：是一种中药植物，常用于活血行气，祛风止痛，川芎辛温香燥，走而不守，既能行散，上行可达巅顶；又入血分，下行可达血海。活血祛瘀作用广泛，适宜瘀血阻滞各种病症；祛风止痛，效用甚佳，可治头风头痛、风湿痹痛等症。
赤芍：清热凉血，散瘀止痛。用于热人营血，温毒发斑，吐血衄血，目赤肿痛，肝郁胁痛，经闭痛经，瘾瘕腹痛，跌扑损伤，痈肿疮疡。
鳖甲：具有滋阴潜阳，退热除蒸,软坚散结之功效。常用于阴虚发热，骨蒸劳热,阴虚阳亢,头晕目眩，虚风内动，经闭，癥瘕，久疟疟母。
莪术：主治“气血凝滞，心腹胀痛，症瘕，积聚，宿食不消，妇女血瘀经闭，跌打损伤作痛。
鸡血藤：具有活血补血，调经止痛，舒筋活络之功效。用于***，痛经，经闭，风湿痹痛，麻木瘫痪，血虚萎黄。
丹参：具有活血祛瘀，通经止痛，清心除烦，凉血消痈之功效。用于胸痹心痛，脘腹胁痛，瘕瘕积聚，热痹疼痛，心烦不眠，***，痛经经闭，疮疡肿痛。
穿山甲：具有活血消症，通经下乳，消肿排脓，搜风通络的功效。用于经闭癓瘕，乳汁不通，痈肿疮毒，风湿痹痛，中风瘫痪，麻木拘挛。
威灵仙：有祛风湿，通经络的作用。用于风湿痹痛，肢体麻木，筋脉拘挛，屈伸不利。
淫羊藿：滋阴补阳，壮阳强身，主治阳萎早泄，腰酸腿痛，四肢麻木，半身不遂，神经衰弱，健忘，耳鸣，目眩等症。
巴戟天：有补肾阳，强筋骨，祛风湿之功效。常用于用于阳痿遗精，宫冷***，***，少腹冷痛，风湿痹痛，筋骨痿软。
甘草：具有补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药之功效。常用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
丝瓜络：有祛风，通络，活血，下乳的功效。用于治疗痹痛拘挛、胸胁胀痛、乳汁不通，乳痈肿痛。
乳香：活血行气止痛，消肿生肌。用于胸痹心痛，胃脘疼痛，痛经经闭，产后瘀阻，症瘕腹痛，风湿痹痛，筋脉拘挛，跌打损伤，痈肿疮疡。
没药：具有散瘀定痛，消肿生肌之功效。常用于胸痹心痛，胃脘疼痛，痛经经闭，产后瘀阻，癥瘕腹痛，风湿痹痛，跌打损伤，痈肿疮疡等病症的治疗。
钩藤：具有息风定惊，清热平肝之功效。常用于肝风内动，惊痫抽搐，高热惊厥，感冒夹惊，小儿惊啼，妊娠子痫，头痛眩晕。
黄柏：有清热燥湿，泻火除蒸，解毒疗疮的功效。用于湿热泻痢，黄疸尿赤，带***痒，热淋涩痛，脚气痿蹙，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹湿疮。盐黄柏滋阴降火。用于阴虚火旺，盗汗骨蒸。
本发明药物选取20种天然中药科学配伍，配方简单，各原料药协同作用起到化瘀驱邪、舒筋通络的效果，见效快，标本兼治，无毒副作用，而且其制备方法简单、服用方便，成本低。
具体实施方式
下面结合实施例对本发明内容作进一步的说明，但不是对本发明的限定。
实施例1
一种用于治疗骨质增生的药物，由下述重量份配比的原料制成：
桃仁8kg、红花3kg、知母8kg、杜仲12kg、川芎3kg、赤芍8kg、鳖甲10kg、莪术8kg、鸡血藤12kg、丹参12kg、穿山甲8kg、威灵仙12kg、淫羊藿12kg、巴戟天12kg、甘草3kg，丝瓜络4kg、乳香3kg、没药3kg、钩藤8kg、黄柏8kg。
本发明药物的制备方法如下：
(1)按重量份配比称取各原料药，将全部原料药粉碎成粗粉，一起混合置于容器中，加入原料量3倍浓度为50％的乙醇浸渍4天后，过滤去渣，滤液减压回收乙醇至无醇味，得浓缩液80kg，备用；
(2)在步骤(1)制得的浓缩液中加入900kg水和0.6kg山梨酸钾，搅匀、静置20h，过滤，得滤液，备用；
(3)另用80kg蔗糖，加100kg水煮沸40kgmin，过滤，备用；
(4)将步骤(2)和(3)的滤液混合置于容器内，加800kg水，冷却后装瓶、密封后进行灭菌处理，制成产品。
实施例2
一种用于治疗骨质增生的药物，由下述重量份配比的原料制成：
桃仁10kg、红花5kg、知母10kg、杜仲15kg、川芎5kg、赤芍10kg、鳖甲12kg、莪术10kg、鸡血藤15kg、丹参15kg、穿山甲10kg、威灵仙15kg、淫羊藿15kg、巴戟天15kg、甘草5kg，丝瓜络6kg、乳香5kg、没药5kg、钩藤10kg、黄柏10kg。
本发明药物的制备方法如下：
(1)按重量份配比称取各原料药，将全部原料药粉碎成粗粉，一起混合置于容器中，加入原料量4倍浓度为55％的乙醇浸渍5天后，过滤去渣，滤液减压回收乙醇至无醇味，得浓缩液90kg，备用；
(2)在步骤(1)制得的浓缩液中加入950kg水和0.8kg份山梨酸钾，搅匀、静置25h，过滤，得滤液，备用；
(3)另用90kg蔗糖，加110kg水煮沸45min，过滤，备用；
(4)将步骤(2)和(3)的滤液混合置于容器内，加900kg水，冷却后装瓶、密封后进行灭菌处理，制成产品。
实施例3
一种用于治疗骨质增生的药物，由下述重量份配比的原料制成：
桃仁12kg、红花7kg、知母12kg、杜仲18kg、川芎7kg、赤芍12kg、鳖15kg、莪术12kg、鸡血藤18kg、丹参18kg、穿山甲12kg、威灵仙18kg、淫羊藿18kg、巴戟天18kg、甘草7kg，丝瓜络8kg、乳香7kg、没药7kg、钩藤12kg、黄柏12kg。
本发明药物的制备方法如下：
(1)按重量份配比称取各原料药，将全部原料药粉碎成粗粉，一起混合置于容器中，加入原料量5倍浓度为60％的乙醇浸渍6天后，过滤去渣，滤液减压回收乙醇至无醇味，得浓缩液100kg，备用；
(2)在步骤(1)制得的浓缩液中加入1000kg水和1kg山梨酸钾，搅匀、静置30h，过滤，得滤液，备用；
(3)另用100kg蔗糖，加120kg水煮沸50min，过滤，备用；
(4)将步骤(2)和(3)的滤液混合置于容器内，加1000kg水，冷却后装瓶、密封后进行灭菌处理，制成产品。
为了进一步证明本发明中药的临床疗效，选择收治患者中的90例，对本发明药物的疗效进行临床观察。年龄45-70岁，随机分为3组，每组为30例，分别为实验组1-3组。
实验组1-3组分别服用实施例1-3的药物，每日3次，每次内服3g，20天为一个疗程，连续服用2个疗程。其中显效85例，有效86例，治愈83例，无效4例，治愈率92.2％，有效率95.6％。

Claims (7)

1.一种用于治疗骨质增生的药物，其特征是：由下述重量份配比的原料制成：
桃仁8-12份、红花3-7份、知母8-12份、杜仲12-18份、川芎3-7份、赤芍8-12份、鳖甲10-15份、莪术8-12份、鸡血藤12-18份、丹参12-18份、穿山甲8-12份、威灵仙12-18份、淫羊藿12-18份、巴戟天12-18份、甘草3-7份，丝瓜络4-8份、乳香3-7份、没药3-7份、钩藤8-12份、黄柏8-12份。
2.根据权利要求1所述的用于治疗骨质增生的药物，其特征是：各原料的重量份配比为：
桃仁10份、红花5份、知母10份、杜仲15份、川芎5份、赤芍10份、鳖甲12份、莪术10份、鸡血藤15份、丹参15份、穿山甲10份、威灵仙15份、淫羊藿15份、巴戟天15份、甘草5份，丝瓜络6份、乳香5份、没药5份、钩藤10份、黄柏10份。
3.如权利要求1所述的用于治疗骨质增生的药物的制备方法，其特征是：具体步骤如下：
(1)按重量份配比称取各原料药，将全部原料药粉碎成粗粉，一起混合置于容器中，加入原料量3-5倍浓度为50-60％的乙醇浸渍4-6天后，过滤去渣，滤液减压回收乙醇至无醇味，得浓缩液80-100份，备用；
(2)在步骤(1)制得的浓缩液中加入900-1000份水和0.6-1份山梨酸钾，搅匀、静置20-30h，过滤，得滤液，备用；
(3)另用80-100份蔗糖，加100-120份水煮沸40-50min，过滤，备用；
(4)将步骤(2)和(3)的滤液混合置于容器内，加800-1000份水，冷却后装瓶、密封后进行灭菌处理，制成产品。
4.根据权利要求3所述的用于治疗骨质增生的药物的制备方法，其特征是：所述步骤(1)中加入的乙醇的浓度为50-60％。
5.根据权利要求3所述的用于治疗骨质增生的药物的制备方法，其特征是：所述步骤(2)中水的加入量为900-1000份，山梨酸钾的加入量为0.6-1份。
6.根据权利要求3所述的用于治疗骨质增生的药物的制备方法，其特征是：所述步骤(3)中的蔗糖的量为80-100份，水的量为100-120份。
7.根据权利要求3所述的用于治疗骨质增生的药物的制备方法，其特征是：所述步骤(4)中水的加入量为800-1000份。
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104000933A (zh) * 2014-06-21 2014-08-27 徐显廷 一种治疗骨质增生的中药口服液
CN105106876A (zh) * 2015-10-12 2015-12-02 刘杰 用于治疗早期骨质增生的药物
CN105106579A (zh) * 2015-10-12 2015-12-02 刘杰 用于治疗后期骨质增生的药物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104000933A (zh) * 2014-06-21 2014-08-27 徐显廷 一种治疗骨质增生的中药口服液
CN105106876A (zh) * 2015-10-12 2015-12-02 刘杰 用于治疗早期骨质增生的药物
CN105106579A (zh) * 2015-10-12 2015-12-02 刘杰 用于治疗后期骨质增生的药物

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