CN106266947A - 用于治疗骨质增生的药物 - Google Patents
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Abstract
本发明公开了一种用于治疗骨质增生的药物,由下述重量份配比的原料制成:桃仁8‑12份、红花3‑7份、知母8‑12份、杜仲12‑18份、川芎3‑7份、赤芍8‑12份、鳖甲10‑15份、莪术8‑12份、鸡血藤12‑18份、丹参12‑18份、穿山甲8‑12份、威灵仙12‑18份、淫羊藿12‑18份、巴戟天12‑18份、甘草3‑7份,丝瓜络4‑8份、乳香3‑7份、没药3‑7份、钩藤8‑12份、黄柏8‑12份。本发明药物选取20种天然中药科学配伍,配方简单,各原料药协同作用起到化瘀驱邪、舒筋通络的效果,见效快,标本兼治,无毒副作用,而且其制备方法简单、服用方便,成本低。有效率达95.6%以上。
Description
技术领域
本发明涉及中药,具体是一种用于治疗骨质增生的药物。
背景技术
骨质增生症多发于中年以上。一般认为由于中年以后体质虚弱及退行性变;长期站立或行走及长时间的持于某种姿势,由于肌肉的牵拉或撕脱、出血,血肿机化,形成刺状或唇样的骨质增生;骨刺对软组织产生机械性的刺激和外伤后软组织损伤、出血、肿胀而致。骨质增生症属中医的"痹证"范畴,亦称"骨痹"。中医认为本病与外伤、劳损、瘀血阻络、感受风寒湿邪、痰湿内阻、肝肾亏虚等有关。由于骨质增生可发生于全身各部,临床表现也就错综复杂,但治则总以补肾健骨、扶正祛邪、活血化瘀、软坚消肿、疏通经络等法为要。
目前,骨质增生的发病率较高,治疗也有多种方式,以药物治疗为主,治疗骨质增生的西药,效果不理想,且有一定的副作用,中药方面则较少,多以一些传统经方辩证治疗,效果也不甚理想。
发明内容
本发明的目的是提供一种疗效好、成本低、无毒副作用的治疗骨质增生的药物。
实现本发明目的的技术方案是:
一种用于治疗骨质增生的药物,由下述重量份配比的原料制成:
桃仁8-12份、红花3-7份、知母8-12份、杜仲12-18份、川芎3-7份、赤芍8-12份、鳖甲10-15份、莪术8-12份、鸡血藤12-18份、丹参12-18份、穿山甲8-12份、威灵仙12-18份、淫羊藿12-18份、巴戟天12-18份、甘草3-7份,丝瓜络4-8份、乳香3-7份、没药3-7份、钩藤8-12份、黄柏8-12份。
上述用于治疗骨质增生的药物,各原料的最佳重量份配比为:
桃仁10份、红花5份、知母10份、杜仲15份、川芎5份、赤芍10份、鳖甲12份、莪术10份、鸡血藤15份、丹参15份、穿山甲10份、威灵仙15份、淫羊藿15份、巴戟天15份、甘草5份,丝瓜络6份、乳香5份、没药5份、钩藤10份、黄柏10份。
所述的原料药材在中药店及市场有售。
本发明药物的制备方法如下:
(1)按重量份配比称取各原料药,将全部原料药粉碎成粗粉,一起混合置于容器中,加入原料量3-5倍浓度为50-60%的乙醇浸渍4-6天后,过滤去渣,滤液减压回收乙醇至无醇味,得浓缩液80-100份,备用;
(2)在步骤(1)制得的浓缩液中加入900-1000份水和0.6-1份山梨酸钾,搅匀、静置20-30h,过滤,得滤液,备用;
(3)另用80-100份蔗糖,加100-120份水煮沸40-50min,过滤,备用;
(4)将步骤(2)和(3)的滤液混合置于容器内,加800-1000份水,冷却后装瓶、密封后进行灭菌处理,制成产品。
本发明中,各原料药的药理、功效如下:
桃仁:具有活血祛瘀,润肠通便,止咳平喘的功效。用于经闭痛经,瘕瘕痞块,肺痈肠痈,跌扑损伤,肠燥便秘,咳嗽气喘。
红花:具有活血通经,散瘀止痛之功效。用于经闭,痛经,恶露不行,症瘕痞块,胸痹心痛,瘀滞腹痛,胸胁刺痛,跌扑损伤,疮疡肿痛。
知母:清热泻火,滋阴润燥。热病烦渴,肺热燥咳,骨蒸潮热,内热消渴,肠燥便秘。
杜仲:有补益肝肾、强筋壮骨、调理冲任、固经安胎的功效。可治疗肾阳虚引起的腰腿痛或酸软无力,肝气虚引起的胞胎不固,阴囊湿痒等症。
川芎:是一种中药植物,常用于活血行气,祛风止痛,川芎辛温香燥,走而不守,既能行散,上行可达巅顶;又入血分,下行可达血海。活血祛瘀作用广泛,适宜瘀血阻滞各种病症;祛风止痛,效用甚佳,可治头风头痛、风湿痹痛等症。
赤芍:清热凉血,散瘀止痛。用于热人营血,温毒发斑,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,瘾瘕腹痛,跌扑损伤,痈肿疮疡。
鳖甲:具有滋阴潜阳,退热除蒸,软坚散结之功效。常用于阴虚发热,骨蒸劳热,阴虚阳亢,头晕目眩,虚风内动,经闭,癥瘕,久疟疟母。
莪术:主治“气血凝滞,心腹胀痛,症瘕,积聚,宿食不消,妇女血瘀经闭,跌打损伤作痛。
鸡血藤:具有活血补血,调经止痛,舒筋活络之功效。用于***,痛经,经闭,风湿痹痛,麻木瘫痪,血虚萎黄。
丹参:具有活血祛瘀,通经止痛,清心除烦,凉血消痈之功效。用于胸痹心痛,脘腹胁痛,瘕瘕积聚,热痹疼痛,心烦不眠,***,痛经经闭,疮疡肿痛。
穿山甲:具有活血消症,通经下乳,消肿排脓,搜风通络的功效。用于经闭癓瘕,乳汁不通,痈肿疮毒,风湿痹痛,中风瘫痪,麻木拘挛。
威灵仙:有祛风湿,通经络的作用。用于风湿痹痛,肢体麻木,筋脉拘挛,屈伸不利。
淫羊藿:滋阴补阳,壮阳强身,主治阳萎早泄,腰酸腿痛,四肢麻木,半身不遂,神经衰弱,健忘,耳鸣,目眩等症。
巴戟天:有补肾阳,强筋骨,祛风湿之功效。常用于用于阳痿遗精,宫冷***,***,少腹冷痛,风湿痹痛,筋骨痿软。
甘草:具有补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药之功效。常用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。
丝瓜络:有祛风,通络,活血,下乳的功效。用于治疗痹痛拘挛、胸胁胀痛、乳汁不通,乳痈肿痛。
乳香:活血行气止痛,消肿生肌。用于胸痹心痛,胃脘疼痛,痛经经闭,产后瘀阻,症瘕腹痛,风湿痹痛,筋脉拘挛,跌打损伤,痈肿疮疡。
没药:具有散瘀定痛,消肿生肌之功效。常用于胸痹心痛,胃脘疼痛,痛经经闭,产后瘀阻,癥瘕腹痛,风湿痹痛,跌打损伤,痈肿疮疡等病症的治疗。
钩藤:具有息风定惊,清热平肝之功效。常用于肝风内动,惊痫抽搐,高热惊厥,感冒夹惊,小儿惊啼,妊娠子痫,头痛眩晕。
黄柏:有清热燥湿,泻火除蒸,解毒疗疮的功效。用于湿热泻痢,黄疸尿赤,带***痒,热淋涩痛,脚气痿蹙,骨蒸劳热,盗汗,遗精,疮疡肿毒,湿疹湿疮。盐黄柏滋阴降火。用于阴虚火旺,盗汗骨蒸。
本发明药物选取20种天然中药科学配伍,配方简单,各原料药协同作用起到化瘀驱邪、舒筋通络的效果,见效快,标本兼治,无毒副作用,而且其制备方法简单、服用方便,成本低。
具体实施方式
下面结合实施例对本发明内容作进一步的说明,但不是对本发明的限定。
实施例1
一种用于治疗骨质增生的药物,由下述重量份配比的原料制成:
桃仁8kg、红花3kg、知母8kg、杜仲12kg、川芎3kg、赤芍8kg、鳖甲10kg、莪术8kg、鸡血藤12kg、丹参12kg、穿山甲8kg、威灵仙12kg、淫羊藿12kg、巴戟天12kg、甘草3kg,丝瓜络4kg、乳香3kg、没药3kg、钩藤8kg、黄柏8kg。
本发明药物的制备方法如下:
(1)按重量份配比称取各原料药,将全部原料药粉碎成粗粉,一起混合置于容器中,加入原料量3倍浓度为50%的乙醇浸渍4天后,过滤去渣,滤液减压回收乙醇至无醇味,得浓缩液80kg,备用;
(2)在步骤(1)制得的浓缩液中加入900kg水和0.6kg山梨酸钾,搅匀、静置20h,过滤,得滤液,备用;
(3)另用80kg蔗糖,加100kg水煮沸40kgmin,过滤,备用;
(4)将步骤(2)和(3)的滤液混合置于容器内,加800kg水,冷却后装瓶、密封后进行灭菌处理,制成产品。
实施例2
一种用于治疗骨质增生的药物,由下述重量份配比的原料制成:
桃仁10kg、红花5kg、知母10kg、杜仲15kg、川芎5kg、赤芍10kg、鳖甲12kg、莪术10kg、鸡血藤15kg、丹参15kg、穿山甲10kg、威灵仙15kg、淫羊藿15kg、巴戟天15kg、甘草5kg,丝瓜络6kg、乳香5kg、没药5kg、钩藤10kg、黄柏10kg。
本发明药物的制备方法如下:
(1)按重量份配比称取各原料药,将全部原料药粉碎成粗粉,一起混合置于容器中,加入原料量4倍浓度为55%的乙醇浸渍5天后,过滤去渣,滤液减压回收乙醇至无醇味,得浓缩液90kg,备用;
(2)在步骤(1)制得的浓缩液中加入950kg水和0.8kg份山梨酸钾,搅匀、静置25h,过滤,得滤液,备用;
(3)另用90kg蔗糖,加110kg水煮沸45min,过滤,备用;
(4)将步骤(2)和(3)的滤液混合置于容器内,加900kg水,冷却后装瓶、密封后进行灭菌处理,制成产品。
实施例3
一种用于治疗骨质增生的药物,由下述重量份配比的原料制成:
桃仁12kg、红花7kg、知母12kg、杜仲18kg、川芎7kg、赤芍12kg、鳖15kg、莪术12kg、鸡血藤18kg、丹参18kg、穿山甲12kg、威灵仙18kg、淫羊藿18kg、巴戟天18kg、甘草7kg,丝瓜络8kg、乳香7kg、没药7kg、钩藤12kg、黄柏12kg。
本发明药物的制备方法如下:
(1)按重量份配比称取各原料药,将全部原料药粉碎成粗粉,一起混合置于容器中,加入原料量5倍浓度为60%的乙醇浸渍6天后,过滤去渣,滤液减压回收乙醇至无醇味,得浓缩液100kg,备用;
(2)在步骤(1)制得的浓缩液中加入1000kg水和1kg山梨酸钾,搅匀、静置30h,过滤,得滤液,备用;
(3)另用100kg蔗糖,加120kg水煮沸50min,过滤,备用;
(4)将步骤(2)和(3)的滤液混合置于容器内,加1000kg水,冷却后装瓶、密封后进行灭菌处理,制成产品。
为了进一步证明本发明中药的临床疗效,选择收治患者中的90例,对本发明药物的疗效进行临床观察。年龄45-70岁,随机分为3组,每组为30例,分别为实验组1-3组。
实验组1-3组分别服用实施例1-3的药物,每日3次,每次内服3g,20天为一个疗程,连续服用2个疗程。其中显效85例,有效86例,治愈83例,无效4例,治愈率92.2%,有效率95.6%。
Claims (7)
1.一种用于治疗骨质增生的药物,其特征是:由下述重量份配比的原料制成:
桃仁8-12份、红花3-7份、知母8-12份、杜仲12-18份、川芎3-7份、赤芍8-12份、鳖甲10-15份、莪术8-12份、鸡血藤12-18份、丹参12-18份、穿山甲8-12份、威灵仙12-18份、淫羊藿12-18份、巴戟天12-18份、甘草3-7份,丝瓜络4-8份、乳香3-7份、没药3-7份、钩藤8-12份、黄柏8-12份。
2.根据权利要求1所述的用于治疗骨质增生的药物,其特征是:各原料的重量份配比为:
桃仁10份、红花5份、知母10份、杜仲15份、川芎5份、赤芍10份、鳖甲12份、莪术10份、鸡血藤15份、丹参15份、穿山甲10份、威灵仙15份、淫羊藿15份、巴戟天15份、甘草5份,丝瓜络6份、乳香5份、没药5份、钩藤10份、黄柏10份。
3.如权利要求1所述的用于治疗骨质增生的药物的制备方法,其特征是:具体步骤如下:
(1)按重量份配比称取各原料药,将全部原料药粉碎成粗粉,一起混合置于容器中,加入原料量3-5倍浓度为50-60%的乙醇浸渍4-6天后,过滤去渣,滤液减压回收乙醇至无醇味,得浓缩液80-100份,备用;
(2)在步骤(1)制得的浓缩液中加入900-1000份水和0.6-1份山梨酸钾,搅匀、静置20-30h,过滤,得滤液,备用;
(3)另用80-100份蔗糖,加100-120份水煮沸40-50min,过滤,备用;
(4)将步骤(2)和(3)的滤液混合置于容器内,加800-1000份水,冷却后装瓶、密封后进行灭菌处理,制成产品。
4.根据权利要求3所述的用于治疗骨质增生的药物的制备方法,其特征是:所述步骤(1)中加入的乙醇的浓度为50-60%。
5.根据权利要求3所述的用于治疗骨质增生的药物的制备方法,其特征是:所述步骤(2)中水的加入量为900-1000份,山梨酸钾的加入量为0.6-1份。
6.根据权利要求3所述的用于治疗骨质增生的药物的制备方法,其特征是:所述步骤(3)中的蔗糖的量为80-100份,水的量为100-120份。
7.根据权利要求3所述的用于治疗骨质增生的药物的制备方法,其特征是:所述步骤(4)中水的加入量为800-1000份。
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CN105106876A (zh) * | 2015-10-12 | 2015-12-02 | 刘杰 | 用于治疗早期骨质增生的药物 |
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