CN106266898A - A kind of vital energy benefiting and the kidney invigorating, the compound preparation and preparation method thereof of defying age - Google Patents
A kind of vital energy benefiting and the kidney invigorating, the compound preparation and preparation method thereof of defying age Download PDFInfo
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Abstract
The invention discloses compound preparation of a kind of vital energy benefiting and the kidney invigorating, defying age and preparation method thereof, specifically, this compound preparation is made up of adjuvant by weight and following Chinese medicinal components: 23 parts of Radix Ginsengs, 20 30 parts of Rhizoma Polygonatis, 20 30 portions of Rhizoma Polygonati Odorati, 20 30 parts of Semen Ziziphi Spinosaes, 46 parts of Poria, 46 parts of Cordyceps militaris (L.) Link., 23 portions of Semen Armeniacae Amarums, 23 parts of Radix Platycodoniss, 23 parts of Flos Chrysanthemi, 23 parts of Fructus Alpiniae Oxyphyllae and 10 20 parts of Fructus Lycii.The method preparing this compound preparation, including pulverizing, ethanol water extraction, blend step.This compound preparation is natural health care, and comprehensive supplementing QI and nourishing YIN, the kidney invigorating lung moistening, peaceful gas are calmed the nerves, without any side effects.The main pharmacodynamics composition of this compound preparation includes saponin, crude polysaccharides, total flavones and alkaloid, supplements and complements each other, and the internal metabolic balance of concertedness ground regulation, promotes the metabolism of body cell, and being eaten for a long time can effectively vital energy benefiting and the kidney invigorating, defying age.
Description
Technical field
The present invention relates to Chinese medicine compound field, be specifically related to a kind of vital energy benefiting and the kidney invigorating, the compound preparation of defying age and preparation thereof
Method.
Background technology
Traditional Chinese medical science the kidney invigorating refers to that the dialectical theory utilizing the traditional Chinese medical science exclusive goes to carry out nourishing kidney.The kidney invigorating refer to by diet, build up one's health by taking tonic,
The means such as body building, the qigong, acupuncture, massage reach to change the state suffered from a deficiency of the kidney.The traditional Chinese medical science is thought, suffer from a deficiency of the kidney point deficiency of the kidney yin and kidney yang
Void, will do different diagnosis and treatment according to different symptoms.This is different from the disease in doctor trained in Western medicine.Sometimes traditional Chinese medical science the kidney invigorating is only one
Prevention process, both can be physics nourishing can also be medicine nourishing.QI invigorating is applicable to internal injury overstrain or sick prolonged deficiency is thin, and sees gas
Short lazy speech, pale complexion, the diseases such as Mental fatigue is unable, wasting.
The aging of cell is closely related with apoptosis.Think in the industry at present, cause apoptotic main extraneous factor
May be free radical, free radical be attacked biomembrane, polyunsaturated fatty acid, DNA, protein and other biological macromole and is caused
Oxidative damage be to cause organism aging process and the principal element of many senile disease.Main free radical in human body is hydroxyl radical free radical
And ultra-oxygen anion free radical.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention aims to provide a kind of vital energy benefiting and the kidney invigorating, the answering of defying age
Square preparation.
The purpose of the present invention realizes by the following technical solutions:
A kind of vital energy benefiting and the kidney invigorating, the compound preparation of defying age, be made up of adjuvant by weight and following Chinese medicinal components: 2-
3 portions of Radix Ginsengs, 20-30 part Rhizoma Polygonati, 20-30 part Rhizoma Polygonati Odorati, 20-30 part Semen Ziziphi Spinosae, 4-6 part Poria, 4-6 part Cordyceps militaris (L.) Link., 2-3 part hardship Fructus Prunis
Core, 2-3 part Radix Platycodonis, 2-3 part Flos Chrysanthemi, 2-3 part Fructus Alpiniae Oxyphyllae and 10-20 part Fructus Lycii.
As preferably, this compound preparation is made up of adjuvant by weight and following Chinese medicinal components: 2-3 part Radix Ginseng, 23-
27 parts of Rhizoma Polygonatis, 23-27 part Rhizoma Polygonati Odorati, 23-27 part Semen Ziziphi Spinosae, 4-6 part Poria, 4-6 part Cordyceps militaris (L.) Link., 2-3 part Semen Armeniacae Amarum, 2-3 part Fructus Citri tangerinaes
Stalk, 2-3 part Flos Chrysanthemi, 2-3 part Fructus Alpiniae Oxyphyllae and 13-17 part Fructus Lycii.
As preferably, this compound preparation is made up of adjuvant by weight and following Chinese medicinal components: 2.5 parts of Radix Ginsengs, 25
Part Rhizoma Polygonati, 25 parts of Rhizoma Polygonati Odorati, 25 parts of Semen Ziziphi Spinosaes, 5 parts of Poria, 5 parts of Cordyceps militaris (L.) Link., 2.5 parts of Semen Armeniacae Amarums, 2.5 parts of Radix Platycodoniss, 2.5 parts of Hang Bai
Chrysanthemum, 2.5 parts of Fructus Alpiniae Oxyphyllae and 15 parts of Fructus Lycii.
As preferably, described adjuvant is maltodextrin and Mel.
As preferably, the number of described maltodextrin is 6-10 part, and the number of Mel is 0.1-0.2 part.
The method that another object of the present invention is to provide above-mentioned compound preparation, comprises the following steps:
1) pulverizing: by the Radix Ginseng of formula ratio, Poria and Cordyceps militaris (L.) Link. pulverizing；
2) cream processed: take the Rhizoma Polygonati of formula ratio, Rhizoma Polygonati Odorati, Semen Ziziphi Spinosae, Semen Armeniacae Amarum, Radix Platycodonis, Flos Chrysanthemi, Fructus Alpiniae Oxyphyllae and Fructus Lycii mixed
Closing, add 8-12 times of ethanol water of material cumulative volume after mixing, infusion is extracted, and collects extracting solution, and concentrating under reduced pressure obtains extractum,
Vacuum drying, pulverizes；
3) mixing: by step 1) fine powder that obtains after pulverizing and step 2) pulverize after the fine powder that obtains, add adjuvant, mixing
Uniformly, compound preparation is obtained.
As preferably, step 1) in, cross 80 mesh sieves after pulverizing.
As preferably, step 2) in, being concentrated into relative density is 1.25-1.30.
As preferably, step 2) in, the operation temperature of concentrating under reduced pressure is 70-80 DEG C, and pressure is 0.06-0.08Mpa.
As preferably, step 2) in, in ethanol water, the volume accounting of ethanol is 10%-20%.
In this compound preparation, the sweet micro-hardship of Radix Ginseng, tepor.Return spleen, lung, the heart, kidney channel.Having strongly invigorating primordial QI, multiple arteries and veins takes off admittedly,
Invigorating the spleen to benefit the lung, promotes the production of body fluid and nourishes blood, the function of Fructus Alpiniae Oxyphyllae of calming the nerves.The main active ingredient of Radix Ginseng is Radix Ginseng total saponins, and it can help to people
The performance of the phagocytic function of body macrophage, regulates internal metabolism state, improves the metaboilic level of body, and vital energy benefiting and the kidney invigorating also resists
Old and feeble.
Rhizoma Polygonati sweet in the mouth, property is put down.Return spleen, lung, kidney channel.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, effect of kidney tonifying.Rhizoma Polygonati is at Gu
In generation, is considered the medicinal plants of " alive for evermore and life lengthening ".The principle active component of Rhizoma Polygonati is polygonatum polysaccharide, polygonatum polysaccharide
Also can significantly improve the phagocytic activity of macrophage, regulate internal metabolism state, improve the metaboilic level of body, Rhizoma Polygonati can also
Eliminate internal free radical, reduce the content of malonaldehyde, vital energy benefiting and the kidney invigorating defying age in hippocampal tissue.
Rhizoma Polygonati and Radix Ginseng complement each other, and Radix Ginseng is tonified Qi of the kidney, Rhizoma Polygonati nourishing YIN and moistening the lung, concertedness ground the kidney invigorating and defying age.Separately
Outward, Radix Ginseng mainly provides Radix Ginseng total saponins active component, and Rhizoma Polygonati mainly provides polygonatum polysaccharide active component, common in terms of two
Effect, to improve the anti-aging effects of this compound preparation.
Rhizoma Polygonati Odorati, property is sweet, is slightly cold.Attach to the lung and stomach meridians.Nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.Hinder for lung stomach-Yin, cough caused by dryness-heat, dry pharynx
Thirsty, interior-heat is quenched one's thirst.Containing polytype chemical composition in Rhizoma Polygonati Odorati, such as steroidal saponin, flavone, alkaloid, sterol and polysaccharide
Deng.Rhizoma Polygonati Odorati can the effectively thymus of mice and the atrophy of spleen.Fragrant solomonseal rhizome polyoses and the effect of polygonatum polysaccharide concertedness ground, can improve body
Middle SOD activity, strengthens the Scavenging activity to free radical, anti-lipid peroxidation, reduces the content of malonaldehyde, thus the most anti-ageing
Always.
Semen Ziziphi Spinosae sugariness is put down, and enters the heart, spleen, liver, gallbladder meridian.Nourishing the liver, mind calming, calm the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitate with fear seized with terror
Sad, excessive thirst, sweating due to debility.The main pharmacological components of Semen Ziziphi Spinosae includes jujuboside, flavonoid and alkaloids.Poria is dry, light,
Taste is put down.GUIXIN, lung, spleen, kidney channel.There is promoting diuresis to eliminate damp pathogen, spleen invigorating, the function of mind calming.Its main pharmaceutical component is pachyman,
Body's immunity, the metaboilic level of regulation body can be effectively facilitated.Semen Ziziphi Spinosae, Poria supplement and complement each other with Radix Ginseng, can effectively promote
Enter body allay excitement calm the nerves, tranquilizing soporific, thus effectively defying age.
Cordyceps militaris (L.) Link. is Ascomycota, meat seat mesh, Cordyceps Cordycepps, the type sepecies of Cordyceps.Its effective ingredient includes ucleosides
Compound, Cordyceps polysaccharide, aminoacid sugar alcohol and sterol, it has the metabolic balance in efficiency balance adjustment body, vital energy benefiting and the kidney invigorating.
Semen Armeniacae Amarum is bitter, tepor；Slightly poisonous.Sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood
Empty Tianjin is withered, dryness of the intestine constipation.Radix Platycodonis bitter in the mouth is pungent, property is put down.Enter lung, stomach warp.Open lung qi dispersing gas, evacuation of pus of eliminating the phlegm.Control exogenous cough, swelling throat
Bitterly, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery is suffered from abdominal pain.Semen Armeniacae Amarum principle active component is amygdaloside, the principle active component of Radix Platycodonis
Platycodin, platycodon root polysaccharide and flavone, the immunologic function of its concertedness ground regulation body, slow down aging.
Flos Chrysanthemi sweet in the mouth, bitter in the mouth, be slightly cold.Return lung, Liver Channel.Dissipate wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy
Dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.Fructus Alpiniae Oxyphyllae is pungent, taste temperature.Enter spleen, kidney channel.Warming the spleen, warming the kidney, solid and gas, arresting seminal emission.Control cold air abdomen
Bitterly, invasion by pathogenic cold vomit and diarrhoea, many salivas, seminal emission, dribbling urination, night many urine.The pharmacology effective ingredient predominantly total flavones of Flos Chrysanthemi and waving
Hair oil, the antioxidation of Fructus Alpiniae Oxyphyllae is mainly composed of total phenols, total ketone with old and feeble, and it all can be effectively improved the antioxidation energy of body
Power, delays the cell ageing that free radical causes.
Fructus Lycii sweet in the mouth, property is put down, is returned liver, kidney channel.There is invigorating the liver and kidney, improving eyesight, effect of lung moistening.Medicine main in Fructus Lycii
Effect composition lycium barbarum polysaccharide also can delaying cell aging effectively.
Compared to existing technology, the beneficial effects of the present invention is:
This compound preparation is natural health care, with Radix Ginseng, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Semen Ziziphi Spinosae, Poria, Cordyceps militaris (L.) Link., Semen Armeniacae Amarum,
Radix Platycodonis, Flos Chrysanthemi, Fructus Alpiniae Oxyphyllae and Fructus Lycii are primary raw material, and comprehensive supplementing QI and nourishing YIN, the kidney invigorating lung moistening, peaceful gas are calmed the nerves, secondary without any poison
Effect.The main pharmacodynamics composition of this compound preparation includes saponin, crude polysaccharides, total flavones and alkaloid, supplements and complements each other, concertedness ground
Regulating internal metabolic balance, promote the metabolism of body cell, being eaten for a long time can effectively vital energy benefiting and the kidney invigorating, defying age.
Detailed description of the invention
Below, in conjunction with detailed description of the invention, the present invention is described further:
The present invention provides the compound preparation of a kind of vital energy benefiting and the kidney invigorating, defying age, by adjuvant by weight and following Chinese medicine
Component is made: 2-3 part Radix Ginseng, 20-30 part Rhizoma Polygonati, 20-30 part Rhizoma Polygonati Odorati, 20-30 part Semen Ziziphi Spinosae, 4-6 part Poria, 4-6 part pupa worm
Grass, 2-3 part Semen Armeniacae Amarum, 2-3 part Radix Platycodonis, 2-3 part Flos Chrysanthemi, 2-3 part Fructus Alpiniae Oxyphyllae and 10-20 part Fructus Lycii.In this formula, adjuvant
For maltodextrin and Mel.
Raw material employed in the present invention all can obtain by the way of commercially available.In detailed description below, all in
Medicine component all meets the Pharmacopoeia of the People's Republic of China one middle respective standard requirement of version in 2010.
Embodiment 1
A kind of vital energy benefiting and the kidney invigorating, the compound preparation of defying age, be made up of following components by weight: 2.5 parts of Radix Ginsengs, 25
Part Rhizoma Polygonati, 25 parts of Rhizoma Polygonati Odorati, 25 parts of Semen Ziziphi Spinosaes, 5 parts of Poria, 5 parts of Cordyceps militaris (L.) Link., 2.5 parts of Semen Armeniacae Amarums, 2.5 parts of Radix Platycodoniss, 2.5 parts of Hang Bai
Chrysanthemum, 2.5 parts of Fructus Alpiniae Oxyphyllae, 15 parts of Fructus Lycii, 7 parts of maltodextrins, 0.15 part of Mel.
The method preparing this compound preparation, comprises the following steps:
1) pulverizing: by 2.5kg Radix Ginseng, 5kg Poria and 5kg Cordyceps militaris (L.) Link. pulverizing, crosses 80 mesh sieves；
2) cream processed: take 25kg Rhizoma Polygonati, 25kg Rhizoma Polygonati Odorati, 25kg Semen Ziziphi Spinosae, 2.5kg Semen Armeniacae Amarum, 2.5kg Radix Platycodonis, 2.5kg Hang Bai
Chrysanthemum, 2.5kg Fructus Alpiniae Oxyphyllae and the mixing of 15kg Fructus Lycii, endure at twice with 10 times of ethanol waters of material cumulative volume after mixing
Boiling extraction, united extraction liquid, 70-80 DEG C is concentrated into mastic relative density as 1.25-with the pressure of 0.06-0.08Mpa
1.30, obtain extractum, vacuum drying, pulverize；In this ethanol water, the volume accounting of ethanol is 15%；
3) mixing: by step 1) fine powder that obtains after pulverizing and step 2) pulverize after the fine powder that obtains mix with 0.15kg Mel
Close, add 7kg maltodextrin, mix homogeneously, obtain compound preparation.
Embodiment 2
A kind of vital energy benefiting and the kidney invigorating, the compound preparation of defying age, be made up of following components by weight: 2 parts of Radix Ginsengs, 30 parts
Rhizoma Polygonati, 20 parts of Rhizoma Polygonati Odorati, 20 parts of Semen Ziziphi Spinosaes, 6 parts of Poria, 4 parts of Cordyceps militaris (L.) Link., 3 parts of Semen Armeniacae Amarums, 2 parts of Radix Platycodoniss, 2 parts of Flos Chrysanthemi, 3 parts of benefits
Intelligence core, 20 parts of Fructus Lycii, 6 parts of maltodextrins, 0.12 part of Mel.
The method preparing this compound preparation, comprises the following steps:
1) pulverizing: by 2kg Radix Ginseng, 6kg Poria and 4kg Cordyceps militaris (L.) Link. pulverizing, crosses 80 mesh sieves；
2) cream processed: take 30kg Rhizoma Polygonati, 20kg Rhizoma Polygonati Odorati, 20kg Semen Ziziphi Spinosae, 3kg Semen Armeniacae Amarum, 2kg Radix Platycodonis, 2kg Flos Chrysanthemi, 3kg
Fructus Alpiniae Oxyphyllae and the mixing of 20kg Fructus Lycii, carry out infusion extraction at twice with 10 times of ethanol waters of material cumulative volume after mixing,
United extraction liquid, 70-80 DEG C is concentrated into mastic relative density as 1.25-1.30 with the pressure of 0.06-0.08Mpa, obtains leaching
Cream, vacuum drying, pulverize；In this ethanol water, the volume accounting of ethanol is 15%；
3) mixing: by step 1) fine powder that obtains after pulverizing and step 2) pulverize after the fine powder that obtains mix with 1.2kg Mel
Close, add 6kg maltodextrin, mix homogeneously, obtain compound preparation.
Embodiment 3
A kind of vital energy benefiting and the kidney invigorating, the compound preparation of defying age, be made up of following components by weight: 3 parts of Radix Ginsengs, 20 parts
Rhizoma Polygonati, 30 parts of Rhizoma Polygonati Odorati, 20 parts of Semen Ziziphi Spinosaes, 4 parts of Poria, 6 parts of Cordyceps militaris (L.) Link., 2 parts of Semen Armeniacae Amarums, 3 parts of Radix Platycodoniss, 3 parts of Flos Chrysanthemi, 2 parts of benefits
Intelligence core, 20 parts of Fructus Lycii, 8 parts of maltodextrins, 0.2 part of Mel.
The method preparing this compound preparation, comprises the following steps:
1) pulverizing: by 3kg Radix Ginseng, 4kg Poria and 6kg Cordyceps militaris (L.) Link. pulverizing, crosses 80 mesh sieves；
2) cream processed: take 20kg Rhizoma Polygonati, 30kg Rhizoma Polygonati Odorati, 20kg Semen Ziziphi Spinosae, 2kg Semen Armeniacae Amarum, 3kg Radix Platycodonis, 3kg Flos Chrysanthemi, 2kg
Fructus Alpiniae Oxyphyllae and the mixing of 20kg Fructus Lycii, carry out infusion extraction at twice with 10 times of ethanol waters of material cumulative volume after mixing,
United extraction liquid, 70-80 DEG C is concentrated into mastic relative density as 1.25-1.30 with the pressure of 0.06-0.08Mpa, obtains leaching
Cream, vacuum drying, pulverize；In this ethanol water, the volume accounting of ethanol is 15%；
3) mixing: by step 1) fine powder that obtains after pulverizing and step 2) pulverize after the fine powder that obtains mix with 0.2kg Mel
Close, add 8kg maltodextrin, mix homogeneously, obtain compound preparation.
Comparative example
A kind of vital energy benefiting and the kidney invigorating, the compound preparation of defying age, be made up of following components by weight: 2.5 parts of Radix Ginsengs, 25
Part Rhizoma Polygonati, 25 parts of Rhizoma Polygonati Odorati, 25 parts of Semen Ziziphi Spinosaes, 5 parts of Poria, 5 parts of Cordyceps militaris (L.) Link., 2.5 parts of Semen Armeniacae Amarums, 2.5 parts of Radix Platycodoniss, 2.5 parts of Hang Bai
Chrysanthemum, 2.5 parts of Fructus Alpiniae Oxyphyllae, 15 parts of Fructus Lycii, 7 parts of maltodextrins, 0.15 part of Mel.
The method preparing this compound preparation, comprises the following steps:
1) pulverizing: by 2.5kg Radix Ginseng, 5kg Poria and 5kg Cordyceps militaris (L.) Link. pulverizing, crosses 80 mesh sieves；
2) cream processed: take 25kg Rhizoma Polygonati, 25kg Rhizoma Polygonati Odorati, 25kg Semen Ziziphi Spinosae, 2.5kg Semen Armeniacae Amarum, 2.5kg Radix Platycodonis, 2.5kg Hang Bai
Chrysanthemum, 2.5kg Fructus Alpiniae Oxyphyllae and the mixing of 15kg Fructus Lycii, carry out infusion extraction twice with 10 times of moisture of material cumulative volume after mixing,
United extraction liquid, 70-80 DEG C is concentrated into mastic relative density as 1.25-1.30 with the pressure of 0.06-0.08Mpa, obtains leaching
Cream, vacuum drying, pulverize；
3) mixing: by step 1) fine powder that obtains after pulverizing and step 2) pulverize after the fine powder that obtains mix with 0.15kg Mel
Close, add 7kg maltodextrin, mix homogeneously, obtain compound preparation.
The compound preparation obtaining embodiment 1-3 and comparative example 1, its dosage form is granule, and preparation packing specification is
1g/ bag, it is recommended that day dose 3, the most three times a day, each 1 bag, adult's body weight press 60kg calculating, and equivalent dosage is 0.05g/
kg.bw。
Detection embodiment
The compound preparation that embodiment 1-3 and comparative example obtain is light yellow particulate powder, and free from extraneous odour is visible by naked eyes
Impurity.
1. functional component inspection
By Ministry of Public Health " health food detection and assessment technique specification " 2003 editions, embodiment 1-3 and comparative example are carried out always
Saponin, crude polysaccharides, the detection of Flavonoid Content, its result is as shown in the table:
Table 1 functional component is checked
As shown in Table 1, the compound preparation that the present invention provides contains can effectively regulate internal metabolism balance, eliminate free radical
Plurality of active ingredients, it is possible to vital energy benefiting and the kidney invigorating, defying age.Comparative example puies forward mode, the dissolution of each effective ingredient and reality only with water
Execute example 1-3 and compare the most relatively fewer, illustrate that the preparation method that the present invention provides can effectively facilitate effective one-tenth with pharmacological action
The dissolution divided.
2. sanitary microorganism detection
By the requirement of GB16740-1997, it is total that the compound preparation obtaining embodiment 1-3 and comparative example 1 carries out bacterium colony
Number, coliform group count, mycete, yeast, gold-coloured staphylococci, Salmonella, shigella, Hemolytic streptococcus health micro-
Biological detection, its result is as shown in the table.
Table 2 sanitary microorganism detects
As seen from the above table, the preparation method that the present invention provides, process control is strong, is difficult to microbial contamination.Embodiment
The sanitary microorganism index of the compound preparation that 1-3 and comparative example obtain is satisfied by the requirement of GB16740-1997.
3. Toxicological evaluation
The compound preparation obtaining embodiment 1-3 and comparative example 1 carries out acute oral toxicity test, genetoxic examination
Test, the sanitary microorganism of 30 days feeding trials of mice detects, and its result is as shown in the table:
Table 3 safety Toxicological Assessment
As seen from the above table, the compound preparation that embodiment 1-3 and comparative example obtain all belongs to non-toxic type, without mutagenicity, greatly
30 days feeding trials of Mus maximum without agent is human body recommended amounts more than 80 times.
4. efficacy test
The compound preparation obtaining embodiment 1 carries out efficacy test, arranges 0.5g/kg.bw, 1.0g/kg.bw and 4.0g/
The low, medium and high dosage of kg.bw, carries out mice (Balb/c) 30 days by corresponding 10 times of recommended dose, 20 times and 80 times respectively
Lymphocyte transformation experiment (mtt assay) and serolysin test, with aquesterilisa gavage as matched group.
The body weight of mice is affected by table 4 compound preparation
In the gavages of 30 days are tested, the compound preparation of each dosage group, to the body weight gains of mice, spleen/body weight ratio, breast
Gland/body weight ratio, compared with matched group, all without significant difference (P > 0.05).
Table 5 lymphocyte transformation test
In lymphocyte transformation test, 1.0g/kg.bw with 4.0g/kg.bw dosage group compared with control group mice, its
There were significant differences for optical density value (P < 0.05).
Table 6 serolysin test
In serolysin test, each dosage group mice has significantly relative to matched group, the antibody product in Mice Body
Difference (P < 0.05), 1.0g/kg.bw and 4.0g/kg.bw dosage group difference more significant (P < 0.01).What i.e. the present invention provided answers
Square preparation, does not has harmful effect to the body weight gains of mice, spleen/body weight ratio, thymus/body weight ratio, and this compound preparation is pushing away
Recommend use under dosage and may be considered comparatively safe.This compound preparation can effectively facilitate the lymphocyte transformation of mice, promotes
The generation of internal serum sanguinin, can effectively regulate the immune metabolic balance in Mice Body, thus the cell improving body is the oldest
Metabolic capacity, effective slow down aging.
It addition, it will be apparent to those skilled in the art that can technical scheme as described above and design, make other
Various corresponding changes and deformation, and all these change and deformation all should belong to the protection of the claims in the present invention
Within the scope of.
Claims (10)
1. a vital energy benefiting and the kidney invigorating, the compound preparation of defying age, it is characterised in that by adjuvant by weight and following Chinese drug-treated group
Point make: 2-3 part Radix Ginseng, 20-30 part Rhizoma Polygonati, 20-30 part Rhizoma Polygonati Odorati, 20-30 part Semen Ziziphi Spinosae, 4-6 part Poria, 4-6 part Cordyceps militaris (L.) Link.,
2-3 part Semen Armeniacae Amarum, 2-3 part Radix Platycodonis, 2-3 part Flos Chrysanthemi, 2-3 part Fructus Alpiniae Oxyphyllae and 10-20 part Fructus Lycii.
Compound preparation the most according to claim 1, it is characterised in that by adjuvant by weight and following Chinese medicinal components
Make: 2-3 part Radix Ginseng, 23-27 part Rhizoma Polygonati, 23-27 part Rhizoma Polygonati Odorati, 23-27 part Semen Ziziphi Spinosae, 4-6 part Poria, 4-6 part Cordyceps militaris (L.) Link., 2-
3 portions of Semen Armeniacae Amarums, 2-3 part Radix Platycodonis, 2-3 part Flos Chrysanthemi, 2-3 part Fructus Alpiniae Oxyphyllae and 13-17 part Fructus Lycii.
Compound preparation the most according to claim 1, it is characterised in that by adjuvant by weight and following Chinese medicinal components
Make: 2.5 parts of Radix Ginsengs, 25 parts of Rhizoma Polygonatis, 25 portions of Rhizoma Polygonati Odorati, 25 parts of Semen Ziziphi Spinosaes, 5 parts of Poria, 5 parts of Cordyceps militaris (L.) Link., 2.5 portions of Semen Armeniacae Amarums, 2.5
Part Radix Platycodonis, 2.5 parts of Flos Chrysanthemi, 2.5 parts of Fructus Alpiniae Oxyphyllae and 15 parts of Fructus Lycii.
4. according to the compound preparation described in any one of claim 1-3, it is characterised in that described adjuvant is maltodextrin and honeybee
Honey.
Compound preparation the most according to claim 4, it is characterised in that the number of described maltodextrin is 6-10 part, Mel
Number be 0.1-0.2 part.
6. the method for the compound preparation of preparation such as any one of claim 1-5, it is characterised in that comprise the following steps:
1) pulverizing: by the Radix Ginseng of formula ratio, Poria and Cordyceps militaris (L.) Link. pulverizing；
2) cream processed: take the Rhizoma Polygonati of formula ratio, Rhizoma Polygonati Odorati, Semen Ziziphi Spinosae, Semen Armeniacae Amarum, Radix Platycodonis, Flos Chrysanthemi, Fructus Alpiniae Oxyphyllae and Fructus Lycii mixing,
Adding 8-12 times of ethanol water of material cumulative volume after mixing, infusion is extracted, and collects extracting solution, and concentrating under reduced pressure obtains extractum, very
Sky dry, pulverize；
3) mixing: by step 1) fine powder that obtains after pulverizing and step 2) pulverize after the fine powder that obtains, add adjuvant, mixing is all
Even, obtain compound preparation.
7. method as claimed in claim 6, it is characterised in that step 1) in, cross 80 mesh sieves after pulverizing.
8. method as claimed in claim 6, it is characterised in that step 2) in, being concentrated into relative density is 1.25-1.30.
9. method as claimed in claim 6, it is characterised in that step 2) in, the operation temperature of concentrating under reduced pressure is 70-80 DEG C,
Pressure is 0.06-0.08Mpa.
10. method as claimed in claim 6, it is characterised in that step 2) in, in ethanol water, the volume accounting of ethanol
For 10%-20%.
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| CN107184798A (en) * | 2017-05-04 | 2017-09-22 | 杭州本草养正堂生物科技有限公司 | A kind of tonifying Qi relieving mental strain and strengthening the kidney, the compound preparation of anti-aging and preparation method thereof |
| CN107569638A (en) * | 2017-09-13 | 2018-01-12 | 广州堂本生物科技有限公司 | Composition with strengthen immunity effect and its preparation method and application |
| CN108114222A (en) * | 2018-02-12 | 2018-06-05 | 董峰 | Chinese medicine composition that a kind of air making-up and spleen enlivening is nourishing liver and kidney and preparation method thereof |
| CN108478739A (en) * | 2018-04-26 | 2018-09-04 | 了凡善源中医药科技（嘉兴）有限公司 | A kind of health products and preparation method thereof adjusting equilibrium between yin and yang |
| CN108853466A (en) * | 2018-09-29 | 2018-11-23 | 河南五极中医药研究院 | Tonifying kidney and strengthening yang Chinese medicine composition of integration of drinking and medicinal herbs and preparation method thereof |
| CN109105819A (en) * | 2018-09-03 | 2019-01-01 | 圣原健康产业有限公司 | Enriching yin invigorating the spleen composition and its preparation method and application |
| CN112137088A (en) * | 2020-09-24 | 2020-12-29 | 琛蓝(美国)营养制品股份有限公司 | Compound composition with antioxidant and anti-aging effects and preparation method and application thereof |
| CN114748602A (en) * | 2022-05-06 | 2022-07-15 | 四川必信科技有限公司 | Cordyceps militaris double-ginseng tablet capable of tonifying kidney and strengthening vitality |
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| CN107184798A (en) * | 2017-05-04 | 2017-09-22 | 杭州本草养正堂生物科技有限公司 | A kind of tonifying Qi relieving mental strain and strengthening the kidney, the compound preparation of anti-aging and preparation method thereof |
| CN107569638A (en) * | 2017-09-13 | 2018-01-12 | 广州堂本生物科技有限公司 | Composition with strengthen immunity effect and its preparation method and application |
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| CN108853466A (en) * | 2018-09-29 | 2018-11-23 | 河南五极中医药研究院 | Tonifying kidney and strengthening yang Chinese medicine composition of integration of drinking and medicinal herbs and preparation method thereof |
| CN112137088A (en) * | 2020-09-24 | 2020-12-29 | 琛蓝(美国)营养制品股份有限公司 | Compound composition with antioxidant and anti-aging effects and preparation method and application thereof |
| CN114748602A (en) * | 2022-05-06 | 2022-07-15 | 四川必信科技有限公司 | Cordyceps militaris double-ginseng tablet capable of tonifying kidney and strengthening vitality |
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