CN106266558A - A kind of Halth-care composition of resisting fatigue and preparation method thereof - Google Patents
A kind of Halth-care composition of resisting fatigue and preparation method thereof Download PDFInfo
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- CN106266558A CN106266558A CN201610723840.XA CN201610723840A CN106266558A CN 106266558 A CN106266558 A CN 106266558A CN 201610723840 A CN201610723840 A CN 201610723840A CN 106266558 A CN106266558 A CN 106266558A
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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Abstract
The invention discloses a kind of Halth-care composition with anti-fatigue effect, described compositions is made up of the raw material containing the Radix Astragali, Radix Angelicae Sinensis, Radix Puerariae, Fructus Lycii, Rhizoma Polygonati, Fructus Hippophae and Punica granatum L. extract, this Halth-care composition kidney tonifying and enriching blood, replenishing QI to invigorate the spleen, lung moistening, dredging the meridian, can abundant alleviating physical fatigue.The present invention also provides for the preparation method of described Halth-care composition.
Description
Technical field
The invention belongs to field of health care products, be specifically related to Halth-care composition of a kind of resisting fatigue and preparation method thereof.
Background technology
Fatigue is a subjective sensation symptom, refers to that a kind of asthenia, energy are not or the used-up sensation in the whole body.Someone
Fatigue is divided into mental fatigue and two aspects of physical fatigue, and mental fatigue is a kind of amotivational subjective sensation with vigilance,
Showing as having one's head in the clouds, do things and be difficult to focus on even thinking deeply difficulty, forgetful, desire declines, error-prone in work, work
Degradation under efficiency.Physical fatigue is to feel that muscle lacks energy or strength, holds after often showing as carrying out certain physical exertion
Fatiguability, or fatigue be difficult to disappear, affect daily life and work the most to some extent.Clinically, physical fatigue and brain
Power fatigue influences each other, and fatigue is the symptom that common, non-specific, coverage is the widest, can be the master of multiple disease
Want symptom or the simultaneous phenomenon of a lot of disease.
Tired existence, can produce a series of clinical symptoms: muscle power and energy or overweight the caused essence of mental workload
God is sleepy, be short of physical strength, in the heart agitation, muscular soreness, lumbar and back pain, chest is uncomfortable, feel dizzy, headache and insomnia, irritated easy
Anger, depressive anxiety, thought difficulty concentration, forgetful, sexual hypofunction etc., eventually affect daily life, working and learning.
The existing bimillennium history of the understanding of Fatigue by Traditional Chinese Medicine, the rationale with extensive knowledge and profound scholarship and the method for the treatment of set up
Experience.Ancient Chinese medicine already has realized that fatigue the most so-called " overwork ".The classical works of the traditional Chinese medical science have many to " tired
Labor " and the discussion of " asthenia card ", as " interior through Plain Questions " is sayed: " overexertion leading to consumption of QI ", " miscellaneous diseases extensively want an asthenia piece " speech " do not stop by work
Then shape is empty ", " your jade letter outline gold collects literary composition " speech " its essence and blood of Lao Zebilao is also ", " impairment of QI must and smart " etc..For etiology and pathogenesis and
Dialectical treatment aspect, the traditional Chinese medical science also has the most penetrating discussion." Plain Questions logical comments deficiency and excess opinion " by the etiology and pathogenesis of asthenia brilliantly
It is summarised as " lack of vital essence resulting in deficiency syndrome "." Plain Questions six saves state of internal organs opinion " cloud " liver person, source of endurance." " difficult through 14 difficult " stand with five serious conditions of leprosy involving five ZANG-organs
Opinion, details clinical manifestation and the Therapeutic Principle of five serious conditions of leprosy involving five ZANG-organs." Medical Treasures of the Golden Chamber arthralgia due to stagnation of blood spleen fatiguing disease " points out that treatment should stress temperature compensation spleen
Kidney.Bright figured woven silk material stone " reason empty unit mirror " is for discussing the monograph of asthenia, in treatment, advocate qi-restoratives from lung, spleen, kidney three is dirty starts with.Cause
This has close pass according to Traditional Chinese medical theory determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, " physical fatigue " morbidity with the function of the internal organs such as liver,spleen,kidney, lung
System, treatment is when to adjust assisting vehicle body function, to dredge mechanism of qi, making negative and positive of qi and blood tend to normal is principle with balance, thus reaches
Restorative purpose.
At present, on domestic market, the health food with alleviating physical fatigue as major function of circulation is more, and formula is the most
Plant various.The health food with alleviating physical fatigue as major function of approved mainly has: president's board American ginseng capsule, section person of outstanding talent
It female board piece recovering capsule, the good chewable tablet of health field board three, Kang Fu carrys out board American ginseng capsule, Kang Fu carrys out board Radix Panacis Quinquefolii buccal tablets etc..Above-mentioned
Product mainly uses Radix Panacis Quinquefolii to be raw material, and Radix Panacis Quinquefolii saponin is one of topmost effective ingredient in Radix Panacis Quinquefolii, is also that physiology is lived
The most significant material of property.Radix Panacis Quinquefolii saponin can be divided into three major types group: Ra group, Rb group (include Ro, Ra1, Ra2, Ra3, Rb1,
Several hypotype such as Rb2, Rb3, Rc, Rd) and Rg group (including six hypotypes of Re, Rg1, Rg2, Rg3, Rh1, Rh2).Correlational study table
Bright, in this three major types group, several monomer physiologically actives of Ra group are more weak, and the physiologically active of Rb group and Rg group is the strongest.
Radix Panacis Quinquefolii is listed in rare Chinese medicine, at alleviating physical fatigue, safeguards that healthy aspect has played positive effect.But it is western
Radix Panacis Quinquefolii price is higher, and the crowd of taking can cause higher financial burden, and therefore market in urgent need resisting fatigue is effective, and price is excellent
The health product of favour.
Summary of the invention
For solving above-mentioned technical problem, an object of the present invention there are provided the health product group of a kind of effective resisting fatigue
Compound, its resisting fatigue effect is notable, and cost is relatively low.
The two of the object of the invention are to provide the preparation method of this Halth-care composition.
The three of the purpose of the present invention are to provide a kind of preparation containing this Halth-care composition.
The above-mentioned purpose of the present invention is achieved through the following technical solutions:
The Halth-care composition of a kind of resisting fatigue, by containing the Radix Astragali, Radix Angelicae Sinensis, Radix Puerariae, Fructus Lycii, Rhizoma Polygonati, Fructus Hippophae and Punica granatum L.
The raw material of extract is made.
Wherein, the Radix Astragali is leguminous plant Radix Astagali Astragalus membranaceus (Fisch.)
Bge.var.mongholicus (Bge.) Hsiao's or Radix Astragali Astragalus membranaceus (Fisch.) Bge.
Dry root.Warm in nature, sweet in the mouth, return lung, spleen channel.Can invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis granulation promoting etc..
When the dry root being classified as umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor are sweet, pungent,
Temperature, returns liver, the heart, spleen channel.Motherland's medical science is thought, when being classified as the panacea of blood man, have replenishing and activating blood, menstruction regulating and pain relieving, moisturize laxation,
Granulation promoting is good for the function of bone.
Radix Puerariae is the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi.Its sweet in the mouth is pungent cool in nature, enters
Spleen, stomach warp, its gas is gently clear, yang invigorating expelling pathogenic factors from muscles, and relieving restlessness of promoting the production of body fluid is quenched the thirst, and kind wine of controlling amasss, for medicinal and edible plant.
Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Nature and flavor are sweet, flat, return
Liver, kidney channel.
Rhizoma Polygonati is liliaceous plant P. kingianum Polygonalum kingianum Coll.et Hemsl., Rhizoma Polygonati
Polygonatum sibiricum Red. or the dry rhizome of Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.Nature and flavor
Sweet, flat, return spleen, lung, kidney channel.Can boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.
Fructus Hippophae is the dry mature fruit of Elaeangnaceae plant Fructus Hippophae Hippophae rhamnoides L..Nature and flavor acid,
Puckery, warm.According to motherland's theory of medicine, Fructus Hippophae has the pharmacology merits such as sharp lung, yang invigorating, spleen invigorating, nourishing the stomach, blood circulation promoting and blood stasis dispelling, dephlogistication and promoting nuscle growth
Effect.
Punica granatum L. extract is the fruit extract of Punica granatum L., and Punica granatum L. (Punica granatuml L.) is perennial fallen leaves fruit
Tree, belongs to Punicaceae Punica species.
The compositions of the present invention is by the raw material containing the Radix Astragali, Radix Angelicae Sinensis, Radix Puerariae, Fructus Lycii, Rhizoma Polygonati, Fructus Hippophae and Punica granatum L. extract
Make.The Radix Astragali, warm, sweet, to return lung, spleen channel, focus on invigorating QI to consolidate the body surface resistance, yang invigorating benefit is defended；Radix Angelicae Sinensis, sweet, pungent, warm, return liver, the heart, spleen channel, weight
In replenishing and activating blood；Radix Puerariae expelling pathogenic factors from muscles promotes the production of body fluid；It is aided with the Fructus Hippophae rich in abundant nutrition materials such as vitamin, mineral, several amino acids
And Punica granatum L. extract, many medicines share, and play tune tonifying five ZANG-organs, Yin-nourishing and Yang-supporting altogether, make essence, gas, blood, body fluid raw active, and row is strong, and
The nourishing on both side of kidney yang, kidney yin, kidney tonifying and enriching blood, replenishing QI to invigorate the spleen, lung moistening, dredging the meridian are reached；Focus on again tune assisting vehicle body
The nutrient substance such as the aminoacid of needs, mineral, vitamin, thus can reach the merit of alleviating physical fatigue.
What the compositions of the present invention was selected is all the raw material of common par, and for needs, long-term taking person greatly reduces economy
Burden, and the medical material of regulation yang blood and qi etc. is pressed reasonable manner compatibility by the present inventor, and the product obtained is through merit
Energy effect verification experimental verification, its resisting fatigue effect is equivalent to even better than contain the product of rare medicinal herbs Radix Panacis Quinquefolii, the particularly present invention
Compositions very big on the impact of blood lactase acid level after motion, with matched group comparing difference highly significant (P < 0.01), can make
Mice keeps relatively stable blood lactase acid level before and after motion, thus can deduce that the compositions of the present invention is by promoting sugar
Energy needed for the aerobic glycolysis supply body movement of unit, thus avoid the sense of aching that health brings by high-intensity exercise, especially
It is applicable to the resisting fatigue needs of players.
As the preferred technical scheme of one, described Halth-care composition is made up of the raw material containing following weight portion: yellow
Stilbene 300～400 parts, Radix Angelicae Sinensis 250～350 parts, Radix Puerariae 100～200 parts, Fructus Lycii 200～300 parts, Rhizoma Polygonati 250～350 parts, sand
Spine 50～150 parts, Punica granatum L. extract 0～100 parts.
As preferably, described compositions is made up of the raw material containing following weight portion: the Radix Astragali 320～360 parts, Radix Angelicae Sinensis 270
～320 parts, Radix Puerariae 120～280 parts, Fructus Lycii 220～280 parts, Rhizoma Polygonati 280～320 parts, Fructus Hippophae 80～120 parts, Punica granatum L. extraction
Thing 20～80 parts.
As preferably, described compositions is made up of the raw material containing following weight portion: the Radix Astragali 350 parts, Radix Angelicae Sinensis 300 parts, Pueraria lobota
Root 150 parts, Fructus Lycii 250 parts, Rhizoma Polygonati 300 parts, Fructus Hippophae 100 parts, Punica granatum L. extract 50 parts.
The described raw material Radix Astragali, Radix Angelicae Sinensis, Radix Puerariae, Fructus Lycii, Rhizoma Polygonati, Fructus Hippophae and Punica granatum L. extract directly can be drunk with soak by water
With, it is also possible to first 6 kinds are made the compositions that extract mixes with Punica granatum L. extract and makes the product being easy to carry about with one and conveniently taking
Product.
As preferably, the described raw material Radix Astragali, Radix Angelicae Sinensis, Radix Puerariae, Fructus Lycii, Rhizoma Polygonati and Fructus Hippophae are made extract；More preferably,
The Radix Astragali, Radix Angelicae Sinensis, Rhizoma Polygonati, Fructus Lycii are made water extract, Radix Puerariae, Fructus Hippophae are made alcohol extraction thing；More preferably, described alcohol extraction
Thing is 70% ethanol extraction.
As preferably, described compositions and some pharmaceutical adjuncts are made the preparation being easy to carry about with one and conveniently taking, such as sheet
Agent, pill, capsule, granule, powder etc., preferably capsule.
Conventional formulation adjuvant of the present invention, including filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent,
Correctives, preservative, substrate etc..Filler includes: dextrin, starch, pregelatinized Starch, lactose, mannitol, chitin, crystallite
Cellulose, sucrose etc.；Disintegrating agent includes: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crosslinked polyethylene pyrrole
Pyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.；Lubricant includes: magnesium stearate, lauryl sulphate acid
Sodium, Pulvis Talci, silicon dioxide etc.；Suspending agent includes: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl first
Base cellulose etc.；Binding agent includes: starch slurry, polyvinylpyrrolidone, hydroxypropyl methyl cellulose etc.；Sweeting agent includes: sugar
Essence sodium, Aspartane, sucrose, cyclamate, enoxolone etc.；Correctives includes: sweeting agent and various essence；Preservative includes:
Parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the eucalyptus oil of acetic acid chloroethene etc.；Substrate bag
Include: PEG6000, PEG4000, insect wax etc..In some embodiments of the invention, compositions being made capsule, adjuvant includes 10-
The dextrin of 50 weight portions, the magnesium stearate of 0-10 weight portion；Preferably include the dextrin of 20 weight portions, the magnesium stearate of 2 weight portions.
The compositions of the present invention can be prepared by following methods:
1) take the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Polygonati, Fructus Lycii, add 6-10 times amount soak by water, extract 1-4 time, extract 1-5h every time, filter
Crossing, merging filtrate, concentrating under reduced pressure obtains thick extractum；
2) taking Radix Puerariae, Fructus Hippophae, with 8-15 times amount 50%-90% ethanol extraction, filter, merging filtrate, concentrating under reduced pressure obtains thick
Extractum；
3) by step 1) and 2) extractum merge, be dried, obtain dry extract, by dry extract pulverize, sieve, obtain fine powder mixing
Thing；
4) take Punica granatum L. extract, sieve, obtain fine powder；
5) by step 3) and 4) fine powder be sufficiently mixed, obtain compositions.
As preferably, described step 1) add 8 times amount soak by water, to extract 2 times, each extraction time is 2h.
As preferably, described step 2) ethanol extraction with 70% 2 times, each 1.5h, ethanol consumption is 10 times for the first time
Amount, ethanol consumption is 8 times amount for the second time.
As preferably, described step 3) and 4) cross 80 mesh sieves.
The beneficial effects of the present invention is: this product is with integration of edible and medicinal herbs raw material prescription, and function is lasting, nontoxic secondary work
With, play integrally-regulated advantage, improve the ability of patient's body fatigue resistance；The present invention focuses on the whole structure of formula, prescription
Scientific and reasonable, adjust tonifying five ZANG-organs, supplement the essence of body, gas, blood, body fluid, comprehensive alleviating physical fatigue, be suitable to tired crowd long-term
Take, prepare safely and effectively health product with lower-cost raw material, inexpensive；And by promoting the aerobic glycolysis of glycogen
Energy needed for supply body movement, reduces the level of blood lactase acid after moving, thus avoids high-intensity exercise to bring health
Ache sense, be particularly well-suited to the resisting fatigue needs of players.
Detailed description of the invention
Below by way of detailed description of the invention, the foregoing of the present invention is described in further detail.But should be by
This is interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to Examples below.All technology realized based on foregoing of the present invention
Belong to the scope of the present invention.
Table 1 formula
| Material name | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 |
| The Radix Astragali | 350g | 350g | 300g | 400g | 360g | 340g |
| Radix Angelicae Sinensis | 350g | 300g | 350g | 320g | 320g | 320g |
| Radix Puerariae | 200g | 150g | 250g | 280g | 220g | 140g |
| Fructus Lycii | 250g | 300g | 200g | 280g | 250g | 230g |
| Rhizoma Polygonati | 300g | 250g | 350g | 320g | 320g | 310g |
| Fructus Hippophae | 100g | 150g | 100g | 140g | 100g | 120g |
| Punica granatum L. extract | 50g | 55g | 100g | 40g | 100g | 100g |
Wherein, Punica granatum L. extract is purchased from Xi'an Ao Jing development in science and technology company limited.
Above formula material can directly be drunk by soak by water, it is also possible to is prepared as the preparation being easy to carry and taking.Below
The preparation of the preparation being easy to carry by enforcement explanation and take.
The preparation of compositions
Embodiment 1
Raw material is prepared according to the formula of embodiment 1 in table 1.
By the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Polygonati, Fructus Lycii water extraction, specifically using soak by water 2 times, each amount of water is 8 times amount,
Every time decocting time is 2h, filters, merging filtrate, and at 70～80 DEG C, vacuum is to be concentrated into relative density under the conditions of 0.08Mpa
It is 1.25～1.30 (60 DEG C), obtains thick extractum I；
By Radix Puerariae, Fructus Hippophae with 70% ethanol extraction 2 times, each 1.5h, add that ethanol is pharmaceutical decocting piece for the first time 10 times
Amount, second time adds 8 times amount, filters, merging filtrate, and at 60 DEG C, vacuum is to be concentrated into relative density under the conditions of 0.08Mpa to be
1.25～1.30 (50 DEG C), obtain thick extractum II；
Being merged by thick extractum I and II, be dried, obtain dry extract, dry extract Universalpulverizer is pulverized, and crosses 80 mesh sieves,
Obtain fine powder A；
Take Punica granatum L. extract and cross 80 mesh sieves, obtain fine powder B.
Fine powder A and fine powder B is sufficiently mixed and i.e. obtains Halth-care composition.
Embodiment 2-6
Preparing raw material according to the formula of embodiment 2-6 in table 1, other steps are same as embodiment 1.
The preparation of health product capsule
Embodiment 7
Take dextrin and cross 80 mesh sieves, obtain fine powder C；
Fine powder C is added in three-dimensional motion mixer with fine powder A and B of embodiment 1 gained and mixes 20min, then 2g is hard
Fatty acid magnesium adds mixer mixing 20min, then in the workshop meeting GMP, uses capsule filling machine to fill capsule, and specification is
0.45g/ grain, obtains the health product capsule with anti-fatigue effect.
Embodiment 8-12
Compositions fine powder prepared by embodiment 2-6 is prepared health product capsule according to embodiment 7 method.
Anti-fatigue effect is tested
Embodiment 13
1, material and method
1.1 samples: the health product capsule being prepared into the present invention according to embodiment 1 and embodiment 7 is sample 1, and content is
Brown ceramic powder, human body recommended amounts every day is 2.7g/60kg.bw.The presidential board American ginseng capsule conduct produced by Beijing Tongrentang
Sample 2, human body recommended amounts every day is 2-4g/60kg.bw.
1.2 laboratory animals: the male mice in kunming 280 provided by institute of lab animals of Sichuan Academy of Medical Sciences
Only, body weight 19-22g, the quality certification number is SCXK (river) 2004-16, SPF level；Experimental animal room is SPF level, uses credit number
For the real dynamic pipe 043 in river, temperature 20-25 DEG C, relative humidity 40-70%.
1.3 dosage choice: laboratory sample 1 and sample 2 are all provided with 450mg/kg.bw, 900mg/kg.bw, 1350mg/kg.bw
Three dosage groups (being about respectively equivalent to the 10 of human body recommended amounts, 20,30 times), weigh 5.63g, 11.25g, 16.88g respectively
Sample 1 and sample 2, respectively add distilled water and be settled to 250ml mixing, be finished and join.Separately set negative control group, often group 40
Animal, is divided into experiment one, two, three, four groups.
1.4 key instruments and reagent: CX4 automatic clinical chemistry analyzer, SBA-40C type bio-sensing analyser, electronics sky
Flat, agitator, swimming trunk, homogenizer, stopwatch, urea kit, anthrone reagent, hemolytic agent, trichloroacetic acid, Glucose standards are molten
Liquid, lactate standard solution.
1.5 experimental technique
1.5.1 with distillation water as solvent preparation tested material, by 20ml/kg.bw per os gavage mice respectively, one is given every day
Secondary, give 30 days continuously.
1.5.2 swimming with a load attached to the body experiment: test after a treated animal last gives tested material 30min, in rat-tail root load 5%
The microfuse of body weight, puts into water temperature 25 ± 1.0 DEG C by mice, the swimming trunk went swimming of depth of water 30cm, and record mice is from swimming
Start to the dead time, calculate the swimming time of mice.
1.5.3 serum urea measure: test two treated animal lasts to tested material 30rnin after, mice is put into temperature 30 DEG C
Water in swimming with a load attached to the body 90min, after rest 60min, pull out eyeball blood sampling 0.5ml, take serum by test kit description operate, use
The CX4 automatic clinical chemistry analyzer of Beckman Coulter Inc. of U.S. production and Guangzhou Biao Jia Science and Technology Ltd. provide
Kit measurement serum urea content.
1.5.4 hepatic glycogen measure: test three treated animal lasts to tested material 30min after, immediately put to death animal take liver warp
Blot with filter paper after normal saline rinsing, accurately weigh l00mg liver, by " health food inspection and assessment technique specification "
Anthrone method in (version in 2003) measures the content of hepatic glycogen.
1.5.5 blood lactase acid measure: test four treated animal lasts to sample 30min after, do not bear a heavy burden in the water middle reaches of temperature 30 DEG C
Stop after swimming l0min.Plasma lactate method: after 0min and swimming, the rest 20min 20u l. that respectively takes a blood sample divides before swimming, after swimming
Jia Ru be after the concussion mixing of 50ul hemolytic agent, then with SBA-40C type bio-sensing analysis-e/or determining.Measurement result is multiplied by dilution times
Several 3.5 are Serum lactic acid content.
1.6 experimental data statistics: experimental data statistics uses SPSS 11.0for windows software kit to process.Data warp
Homogeneity test of variance, variance is neat, carries out variance analysis, if P value is less than 0.05, then compares two-by-two by Dunnett method: if side
Difference is uneven, then carry out data conversion, the most uneven, uses rank test instead, if P value is less than 0.05, then enters by Dunnett's T3 method
Row compares two-by-two.
2. result
The impact on Mouse Weight of 2.1 samples:
From table 2,3,4, the original body mass of three dosage groups and control group mice is through homogeneity test of variance, and variance is neat,
And the results of analysis of variance (P > 0.05) illustrates that the original body mass between each treated animal is equilibrium.The mid-term of three dosage treated animals
Body weight compared with matched group, all without significant difference (P > 0.05), illustrates sample and the reference substance body to mice with end body weight
Weight does not produce impact.
The original body mass of mice respectively organized by table 2
The body weight in mid-term of mice respectively organized by table 3
The body weight in latter stage of mice respectively organized by table 4
The impact on the mice burden swimming time of 2.2 samples:
From table 5, the walking weight load of 1,2 three dosage group mices of sample has extended compared with matched group,
And in addition to sample 2 low dose group there was no significant difference (P>0.05), the walking weight load of each dosage group significantly extend (P<
0.05), the diversity highly significant (P < 0.01) of especially sample 1.
The impact on the mice burden swimming time of table 5 sample
Note: * compared with matched group, P < 0.05；* compared with matched group, P < 0.01.
2.3 samples are on the impact of serum urea after mouse movement:
From table 6,1 three dosage group mices of sample have notable difference compared with serum urea after matched group motion,
And difference highly significant (P < 0.01), the high dose group of sample 2 has significant difference (P < 0.05).
Table 6 sample is on the impact of serum urea after mouse movement
Note: * compared with matched group, P < 0.05；* compared with matched group, P < 0.01.
The impact on Mouse Liver glycogen of 2.4 samples:
From table 7, the hepatic glycogen content of 1 three dosage group mices of sample compared with matched group, have significant difference (P <
0.05), particularly middle high dose group difference highly significant (P < 0.01), the hepatic glycogen content of sample 2 high dose group significantly rises
High (P < 0.05).
The impact on Mouse Liver glycogen of table 7 sample
Note: * compared with matched group, P < 0.05；* compared with matched group, P < 0.01.
2.5 samples are on the impact of blood lactase acid level after mouse movement:
From table 8, area and matched group phase under the blood lactase acid level curve after 1 three dosage group mouse movements of sample
Ratio, lactate level significance reduces (P<0.01), although and sample 2 compares with matched group and decreases, but without significant difference (P>
0.05)。
Table 8 sample is on the impact of blood lactase acid level after mouse movement
Note: * * compared with matched group, P < 0.01.
3. brief summary
After continuous 30 days per os gavages of the health product capsule of the present invention give animal, the weight of animals is had no significant effect.Three
The serum urea of individual dosage group significantly reduces, and serum urea measurement result is positive；Walking weight load significantly extends, swimming with a load attached to the body
Swimming experimental result is positive；Hepatic glycogen content dramatically increases, and hepatic glycogen measurement result is positive；Blood lactase acid area under curve is the most non-
Often being substantially less than matched group, blood lactase acid measurement result is positive.Animal is had and significantly alleviates muscle power by this capsule as can be seen here
Fatigue function.
The invention is not limited in aforesaid detailed description of the invention.The present invention expands to any disclose in this manual
New feature or any new combination, and the arbitrary new method that discloses or the step of process or any new combination.
Claims (10)
1. the Halth-care composition of a resisting fatigue, it is characterised in that described compositions is by the raw material system containing following weight portion
Become: the Radix Astragali 300～400 parts, Radix Angelicae Sinensis 250～350 parts, Radix Puerariae 100～200 parts, Fructus Lycii 200～300 parts, Rhizoma Polygonati 250～350
Part, Fructus Hippophae 50～150 parts, Punica granatum L. extract 0～100 parts.
2. the Halth-care composition of resisting fatigue as claimed in claim 1, it is characterised in that described compositions is by containing following weight
The raw material of amount part is made: the Radix Astragali 320～360 parts, Radix Angelicae Sinensis 300～350 parts, Radix Puerariae 140～280 parts, Fructus Lycii 230～300 parts,
Rhizoma Polygonati 280～320 parts, Fructus Hippophae 100～150 parts, Punica granatum L. extract 40～100 parts.
3. the Halth-care composition of resisting fatigue as claimed in claim 1, it is characterised in that described compositions is by containing following weight
Amount part raw material make: the Radix Astragali 350 parts, Radix Angelicae Sinensis 350 parts, Radix Puerariae 200 parts, Fructus Lycii 250 parts, Rhizoma Polygonati 300 parts, Fructus Hippophae 100 parts,
Punica granatum L. extract 50 parts.
4. the Halth-care composition of resisting fatigue as claimed in claim 1, it is characterised in that by the described Radix Astragali, Radix Angelicae Sinensis, Radix Puerariae,
Fructus Lycii, Rhizoma Polygonati and Fructus Hippophae are prepared as extract.
5. the Halth-care composition of resisting fatigue as claimed in claim 4, it is characterised in that described extract refer to by the Radix Astragali,
Radix Angelicae Sinensis, Rhizoma Polygonati, Fructus Lycii make water extract, and Radix Puerariae, Fructus Hippophae are made alcohol extraction thing.
6. the Halth-care composition of resisting fatigue as claimed in claim 5, it is characterised in that described alcohol extraction thing is 70% ethanol
Extract.
7. the preparation containing the Halth-care composition of the resisting fatigue described in claim 1-6 any one, it is characterised in that institute
Stating preparation is capsule.
8. preparation as claimed in claim 7, it is characterised in that described preparation includes the dextrin of 10-50 weight portion, 0-10 weight
The magnesium stearate of part；The most described preparation includes the dextrin of 20 weight portions, the magnesium stearate of 2 weight portions.
9. the method preparing the Halth-care composition of resisting fatigue described in claim 1-6 any one, including walking as follows
Rapid:
Take the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Polygonati, Fructus Lycii, add 6-10 times amount soak by water, extract 1-4 time, extract 1-5h every time, filter, merge
Filtrate, concentrating under reduced pressure obtains thick extractum；
Taking Radix Puerariae, Fructus Hippophae, with 8-15 times amount 50%-90% ethanol extraction, filter, merging filtrate, concentrating under reduced pressure obtains thick extractum；
By step 1) and 2) extractum merge, be dried, obtain dry extract, by dry extract pulverize, sieve, obtain fine powder mixture；
Take Punica granatum L. extract, sieve, obtain fine powder；
By step 3) and 4) fine powder be sufficiently mixed, obtain compositions.
10. preparation method as claimed in claim 9, it is characterised in that
Described step 1) add 8 times amount soak by water, to extract 2 times, each extraction time is 2h；
Described step 2) ethanol extraction with 70% 2 times, each 1.5h, ethanol consumption is 10 times amount, for the second time ethanol for the first time
Consumption is 8 times amount；
Described step 3) and 4) cross 80 mesh sieves.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107048129A (en) * | 2017-05-11 | 2017-08-18 | 广州善康生物科技有限公司 | A kind of antifatigue crocodile polypeptide beverage |
| CN108452190A (en) * | 2018-06-27 | 2018-08-28 | 桐城市泰安中药材种植专业合作社 | A kind of anti-fatigue health-product containing and its processing method |
| CN108902417A (en) * | 2018-09-21 | 2018-11-30 | 苏州经贸职业技术学院 | A kind of health protection tea of antifatigue and increasing immune power and preparation method thereof |
| CN111973708A (en) * | 2020-08-07 | 2020-11-24 | 盈姿生物科技(上海)有限公司 | Traditional Chinese medicine capsule for relieving physical fatigue and preparation method thereof |
| CN112401246A (en) * | 2020-11-20 | 2021-02-26 | 江阴天江药业有限公司 | Liquid beverage capable of tonifying qi, tonifying kidney and resisting fatigue and preparation method thereof |
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- 2016-08-25 CN CN201610723840.XA patent/CN106266558A/en active Pending
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107048129A (en) * | 2017-05-11 | 2017-08-18 | 广州善康生物科技有限公司 | A kind of antifatigue crocodile polypeptide beverage |
| CN108452190A (en) * | 2018-06-27 | 2018-08-28 | 桐城市泰安中药材种植专业合作社 | A kind of anti-fatigue health-product containing and its processing method |
| CN108902417A (en) * | 2018-09-21 | 2018-11-30 | 苏州经贸职业技术学院 | A kind of health protection tea of antifatigue and increasing immune power and preparation method thereof |
| CN111973708A (en) * | 2020-08-07 | 2020-11-24 | 盈姿生物科技(上海)有限公司 | Traditional Chinese medicine capsule for relieving physical fatigue and preparation method thereof |
| CN112401246A (en) * | 2020-11-20 | 2021-02-26 | 江阴天江药业有限公司 | Liquid beverage capable of tonifying qi, tonifying kidney and resisting fatigue and preparation method thereof |
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