CN106266332A - A kind of oral liquid with effect for reducing blood fat - Google Patents
A kind of oral liquid with effect for reducing blood fat Download PDFInfo
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- CN106266332A CN106266332A CN201610854591.8A CN201610854591A CN106266332A CN 106266332 A CN106266332 A CN 106266332A CN 201610854591 A CN201610854591 A CN 201610854591A CN 106266332 A CN106266332 A CN 106266332A
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- hyperlipidemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
The invention belongs to pharmaceutical technology field, especially treat medicine or the health product of hyperlipidemia.The technical problem to be solved, is to provide a kind of Chinese medicine compound having effect for reducing fat, and makes the oral liquid be easy to carry with and use at any time, can be prepared as concentrated solution or non-concentrated liquid.Preferably it is made up of the crude drug of following weight parts: JINHUA Flos Camelliae Japonicae 45 parts, leaf of Camellia nitidissima Chi 80 parts, Folium Crataegi 65 parts, Herb Gynostemmae Pentaphylli 32 parts, Rhizoma Alismatis 12 parts, Fructus Momordicae 10 parts.The pharmacological results shows, oral liquid of the present invention has an effect of TG and TC in the hyperlipidemia wistar rat blood serum reducing high lipid food induction, and can suppress the rising of LDL C, has positive Regulating Blood Lipid Effect.
Description
Technical field
The invention belongs to pharmaceutical technology field, especially treat medicine or the health product of hyperlipidemia.
Background technology
Hyperlipidemia is also known as disorders of lipid metabolism or dyslipidemia.Can behave as hypercholesterolemia, hypertriglyceridemia or
Mix type hyperlipidemia.In recent years, along with aged tendency of population increases the weight of the change with dietary habit, the people suffering from hyperlipidemia more comes
The most, and have the trend that low age falls ill.
If, there is certain side effect, at present even more pacifying in the drug main Western medicine of clinical treatment hyperlipidemia
Full statins also has the risk of myalgia and rhabdomyolysis.And need long-time treatment.Therefore hyperlipemia
Modern medical therapy be one long-term, the most expensive and have the task of certain security risk.Comparatively speaking, Chinese medicine pair
The treatment and prevention of hyperlipidemia all have good effect, and much Chinese medicine uses through hundreds of more than one thousand years, is proved to side effect
The least.
Chinese medicine is thought, it should main treat hyperlipidemia in terms of two: the first is radically reformed, will be too much in human body
Fat-removal, and keep the lipometabolic normal operation of human body, conventional has soothing the liver promoting diuresis, dispelling phlegm and eliminating dampness method, activating blood and removing stasis Method
Deng；It two is to consolidate, and the basic pathogenesis of hyperlipidemia is deficiency in origin and excess in superficiality, phlegm-dampness stagnation, deficiency of spleen and stomach, conventional useful of the method that consolidates
Gas is invigorated blood circulation, invigorating the spleen for eliminating dampness, kidney tonifying are let out turbid.The present invention is made in consideration the two aspect.
Camellia nitidissima Chi Camellia nitidissima be Theaceae Theaceae Camellia Camellia evergreen shrubs or
Dungarunga, its flower and leaf are Zhuang nationality in Guangxi traditional medication among the people, according to " Guangxi Chinese crude drug standard ", the note such as " modern Compendium of Materia Medica "
Carry, can be used for preventing and treating pharyngolaryngitis, nephritis, dysentery, tumor, have blood in stool, the disease such as hypertension and menoxenia." strong medicine a collection of selected materials " is recorded
The nature and flavor of JINHUA Flos Camelliae Japonicae and leaf are: flower: Tiao Long road, hemostasis.For hypertension, hyperlipidemia, have blood in stool, metrorrhagia；Leaf: micro-hardship, puckery,
Flat.Flower and the function of leaf: Tiao Long road, adjust anus, water channel, heat clearing away poison, dehumidifying poison.For pharyngalgia, edema, hypertension, hyperlipidemia,
The diseases such as jaundice.Owing to Camellia nitidissima Chi is always famous and precious plant, holding at high price, to the exploitation band of follow-up Related product of flower
Carry out no small cost pressure.Prior art for Camellia nitidissima Chi deep processing and exploitation is mainly by lyophilizing or vacuum drying skill at present
Art, is prepared as scented tea by flower, but the flower of the condition difference such as broken, too small, irregular is often dropped, additionally, for leaf
Utilizing, seldom, these are all unfavorable for making full use of resource prior art report.
Folium Crataegi be rosaceous plant Fructus Pyri Pashiae Crataegus pinnatifida Bge.var.major N.E.Br. or
The dried leaves of Fructus Crataegi Crataegus pinnatifida Bge.." Chinese Pharmacopoeia " (2015 editions) record Folium Crataegi nature and flavor with return
Warp: acid, flat, return Liver Channel.Its function with cure mainly as blood circulation promoting and blood stasis dispelling, regulate the flow of vital energy and promote blood circulation, change turbid blood fat reducing.For qi depression to blood stasis, the thoracic obstruction heart
Bitterly, chest distress, palpitation and amnesia, vertigo and tinnitus, hyperlipemia.Relative to the fruit of Fructus Crataegi, Folium Crataegi also has good fall
Blood fat function and good mouthfeel, and cost is much lower.
Herb Gynostemmae Pentaphylli is the herb of cucurbitaceous plant Gynostemma pentaphyllum (Thunb.) Makino, calls five
Pawl gold dragon, snake king, comospore Herb Gynostemmae Pentaphylli." strong medicine a collection of selected materials " records the nature and flavor of Herb Gynostemmae Pentaphylli: bitter, micro-sweet, cool.Function is: tune anus,
Air flue, heat clearing away poison, qi-restoratives, anticancer.Weak for body void, the disease such as hypertension, hyperlipidemia, cough.
Rhizoma Alismatis is the dry tuber of Notes On Alism At Aceae Alisma orientale (Sam.) Juzep.." Chinese Pharmacopoeia "
(2015 editions) record the nature and flavor of Folium Crataegi with return through: sweet, light, cold.Return kidney, bladder warp.Its function with cure mainly as promoting diuresis to eliminate damp pathogen,
Expel the heat-evil, change turbid blood fat reducing.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipemia.
Fructus Momordicae is cucurbitaceous plant Siraitia grosvenorii (Swingle) C.Jeffrey ex Lu et
The dry fruit of Z.Y.Zhang, another name draws Chinese fruit, Herba Cardiospermi Halicacabi, Semen Momordicae." Chinese Pharmacopoeia " (2015 editions) record Fructus Momordicae
Nature and flavor with return through: sweet, cool.Return lung, large intestine channel.Function with cure mainly: clearing heat and moistening lung, relieving sore throat to recover voice, laxation relieving constipation.Dry for lung-heat
Cough, pharyngalgia aphonia, dryness of the intestine constipation.This is had the most supplementary by " Guangxi characteristic Chinese herbal medicine ": cures mainly lung-heat phlegm-fire cough, only reduces phlegm
Cough.
In prior art, Chinese traditional medicines depressing lipid compound recipe use mostly form with granule, some be made as tablet or
Teabag, use the most inconvenience: tablet need use water help swallow, granule and teabag need hot water, stirring and long time
Between wait.The youngster being accustomed to fast pace life often feels to facilitate not, is even reluctant to use.Comparatively speaking, oral liquid
Form is the most easy-to-use, even if also can plug and play when not having water or take the vehicles such as subway, bus.Fully cater to
The behavioral characteristic of younger generation people " impunity just sees the mobile phone, and remembers and just can drink ".
In the present patent application, Camellia nitidissima Chi, Folium Crataegi, Rhizoma Alismatis, Herb Gynostemmae Pentaphylli all have effect for the treatment of hyperlipidaemic conditions, they
Pharmacological mechanism and action target spot are incomplete same, share can the formation of the unnecessary blood fat of multiple blocking-up, reduce lipids contents,
The benefit effect of effective superposition.Herb Gynostemmae Pentaphylli and Fructus Momordicae more have heat-clearing and toxic substances removing, thirst-quenching summer-heat relieving, sore-throat relieving tonifying the lung, the merit of flavor adjustment concurrently
Really.
Summary of the invention
The technical problem to be solved, is to provide a kind of Chinese medicine compound having effect for reducing fat, and make be easy to
The oral liquid that body carries and uses at any time, can be prepared as concentrated solution or non-concentrated liquid.
The technical scheme is that
The square foundation of the present composition is made up of the crude drug of following weight parts:
JINHUA Flos Camelliae Japonicae 60-120 part, Folium Crataegi 40-90 part, Herb Gynostemmae Pentaphylli 25-45 part, Rhizoma Alismatis 6-18 part, Fructus Momordicae 5-20 part.
Can also be made up of the crude drug of following weight parts:
Leaf of Camellia nitidissima Chi 80-160 part, Folium Crataegi 40-90 part, Herb Gynostemmae Pentaphylli 25-45 part, Rhizoma Alismatis 6-18 part, Fructus Momordicae 5-20 part.
Can also be made up of the crude drug of following weight parts:
JINHUA Flos Camelliae Japonicae 30-60 part, leaf of Camellia nitidissima Chi 50-100 part, Folium Crataegi 40-90 part, Herb Gynostemmae Pentaphylli 25-45 part, Rhizoma Alismatis 6-18
Part, Fructus Momordicae 5-20 part.
The present composition can adjust the composition of crude drug as the case may be in square foundation, preferably by following weight parts
Crude drug make:
JINHUA Flos Camelliae Japonicae 45 parts, leaf of Camellia nitidissima Chi 80 parts, Folium Crataegi 65 parts, Herb Gynostemmae Pentaphylli 32 parts, Rhizoma Alismatis 12 parts, Fructus Momordicae 10 parts.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1
Step 1: clean, weigh JINHUA Flos Camelliae Japonicae 60 parts, Folium Crataegi 40 parts, Herb Gynostemmae Pentaphylli 25 parts, Rhizoma Alismatis 6 parts, Fructus Momordicae 5 parts.
Step 2: add the soak by water secondary of 6 times of weight, each 2 hours, filter, discard filtering residue, merging filtrate, subtract at 70 DEG C
Pressure is concentrated into heat and surveys the concentrated solution that relative density is 1.08～1.20, places refrigerator cold-storage overnight, crosses leaching supernatant, or does not puts
Put after refrigerator is directly centrifuged and take supernatant.
Step 3: the supernatant of step 2 gained adds the 60-90% ethanol water (volume of supernatant volume 20-40%
Percentage ratio, lower same) carry out precipitate with ethanol, take supernatant after being centrifuged.
Step 4: add appropriate flavoring agent, stabilizer, antioxidant, regulating acid agent after the supernatant concentration of step 3 gained, carry out
Get product after fill, sterilization.Can not also concentrate, directly be prepared as the finished product that concentration is diluter.
Embodiment 2
Step 1,2 with embodiment 1.
Step 3: the supernatant of step 2 gained adds appropriate emulsifying agent and clarifier, stirs 10 minutes under room temperature, after being centrifuged
Take supernatant.
Step 4 is with embodiment 1.
Embodiment 3
Step 1: clean, weigh JINHUA Flos Camelliae Japonicae 120 parts, Folium Crataegi 90 parts, Herb Gynostemmae Pentaphylli 45 parts, Rhizoma Alismatis 18 parts, Fructus Momordicae 20
Part.
Remaining step is with embodiment 1.
Embodiment 4
Step 1: clean, weigh leaf of Camellia nitidissima Chi 80 parts, Folium Crataegi 40 parts, Herb Gynostemmae Pentaphylli 25 parts, Rhizoma Alismatis 6 parts, Fructus Momordicae 5 parts.
Remaining step is with embodiment 1.
Embodiment 5
Step 1: clean, weigh JINHUA Flos Camelliae Japonicae 30 parts, leaf of Camellia nitidissima Chi 50 parts, Folium Crataegi 40 parts, Herb Gynostemmae Pentaphylli 25 parts, Rhizoma Alismatis 6
Part, Fructus Momordicae 5 parts.
Remaining step is with embodiment 2.
Embodiment 6
Step 1: clean, weigh JINHUA Flos Camelliae Japonicae 60 parts, leaf of Camellia nitidissima Chi 100 parts, Folium Crataegi 90 parts, Herb Gynostemmae Pentaphylli 45 parts, Rhizoma Alismatis
18 parts, Fructus Momordicae 20 parts.
Remaining step is with embodiment 2.
Embodiment 7
Step 1: clean, weigh JINHUA Flos Camelliae Japonicae 45 parts, leaf of Camellia nitidissima Chi 80 parts, Folium Crataegi 65 parts, Herb Gynostemmae Pentaphylli 32 parts, Rhizoma Alismatis 12
Part, Fructus Momordicae 10 parts.
Remaining step is with embodiment 2.
Embodiment 8
Take 20 mices and carry out maximum dosage-feeding test, converse rat experiment dosage.Take 4 week old male wistar
Rat 40, adaptability take at random by body weight after feeding 30 high lipid foods (1% cholesterol, 10% Adeps Sus domestica, 10% yolk powder and
79% normal feedstuff) feed, remaining 10 for Normal group, give common rat feed.Fed with high is taken after 3 weeks
Rat, is randomly divided into model group, oral liquid group of the present invention, positive controls (atorvastatin), often group 10 by body weight.Normally
Matched group gives normal saline, and model group, oral liquid group of the present invention, positive controls continuation high lipid food are fed, and continuous 4
Week.
After last is administered, fasting can't help water 12 hours, and animal is with abdominal aortic blood about 10 after 2% pentobarbital sodium anesthesia
Milliliter, left at room temperature 1 hour, 4000rpm is centrifuged 10 minutes, collects supernatant, i.e. serum, measures four blood lipids index (sweet
Oil three fat TG, serum total cholesterol TC, HDL-C HDL-C, low-density lipoprotein cholesterol LDL-C), operation
Carry out by test kit description method.Experimental data is usedRepresent, use Graphpad-Prism 6.02 to carry out adding up credit
Analysis, t inspection investigation group difference, P ＜ 0.05 is for having statistical significance.Result is as shown in table 1 below:
Table 1 oral liquid of the present invention on the impact of four blood lipids index of hyperlipemia rat (n=10,)
Note: compared with model group,*P ＜ 0.05,**P ＜ 0.01
Visible, model group, after the high fat being carried out continuously 7 weeks is fed, compares with model group, oral liquid group LDL-of the present invention
C, TG and TC content substantially reduces (P ＜ 0.01 or P ＜ 0.05), and HDL-C does not then have significant difference.Result shows, the present invention
Oral liquid has the effect of TG and TC in the hyperlipidemia wistar rat blood serum reducing high lipid food induction, and can suppress LDL-C
Rising, have positive Regulating Blood Lipid Effect.
Claims (5)
1. having an oral liquid for effect for reducing blood fat, its feature is, is made up of the crude drug of following weight parts: JINHUA Flos Camelliae Japonicae
60-120 part, Folium Crataegi 40-90 part, Herb Gynostemmae Pentaphylli 25-45 part, Rhizoma Alismatis 6-18 part, Fructus Momordicae 5-20 part.
2. having an oral liquid for effect for reducing blood fat, its feature is, is made up of the crude drug of following weight parts: leaf of Camellia nitidissima Chi
80-160 part, Folium Crataegi 40-90 part, Herb Gynostemmae Pentaphylli 25-45 part, Rhizoma Alismatis 6-18 part, Fructus Momordicae 5-20 part.
3. having an oral liquid for effect for reducing blood fat, its feature is, is made up of the crude drug of following weight parts: JINHUA Flos Camelliae Japonicae
30-60 part, leaf of Camellia nitidissima Chi 50-100 part, Folium Crataegi 40-90 part, Herb Gynostemmae Pentaphylli 25-45 part, Rhizoma Alismatis 6-18 part, Fructus Momordicae 5-20 part.
4. oral liquid as claimed in claim 3, its feature is, is made up of the crude drug of following weight parts: JINHUA Flos Camelliae Japonicae 45 parts,
Leaf of Camellia nitidissima Chi 80 parts, Folium Crataegi 65 parts, Herb Gynostemmae Pentaphylli 32 parts, Rhizoma Alismatis 12 parts, Fructus Momordicae 10 parts.
5. oral liquid purposes in terms of the medicine or health product for the treatment of hyperlipidemia as described in claim 1 to 4.
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| CN201610854591.8A CN106266332A (en) | 2016-09-27 | 2016-09-27 | A kind of oral liquid with effect for reducing blood fat |
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| CN201610854591.8A CN106266332A (en) | 2016-09-27 | 2016-09-27 | A kind of oral liquid with effect for reducing blood fat |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109221551A (en) * | 2018-11-20 | 2019-01-18 | 广西中医药大学 | A kind of reducing blood lipid antioxidant health-care tea and preparation method thereof |
| CN109464609A (en) * | 2018-11-20 | 2019-03-15 | 广西中医药大学 | Composition and preparation method thereof with effect for reducing blood fat |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103719496A (en) * | 2013-12-31 | 2014-04-16 | 青岛恒波仪器有限公司 | Hawthorn leaf health-care tea for reducing fat and losing weight and preparation method thereof |
-
2016
- 2016-09-27 CN CN201610854591.8A patent/CN106266332A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103719496A (en) * | 2013-12-31 | 2014-04-16 | 青岛恒波仪器有限公司 | Hawthorn leaf health-care tea for reducing fat and losing weight and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张萍: "金花茶的花提取物降血脂作用研究", 《中国优秀硕士学位论文全文数据库-医药卫生科技辑》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109221551A (en) * | 2018-11-20 | 2019-01-18 | 广西中医药大学 | A kind of reducing blood lipid antioxidant health-care tea and preparation method thereof |
| CN109464609A (en) * | 2018-11-20 | 2019-03-15 | 广西中医药大学 | Composition and preparation method thereof with effect for reducing blood fat |
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Application publication date: 20170104 |