CN106264791B - The method for carrying medicine aorta petal is prepared based on 3D printing and carries medicine aorta petal - Google Patents
The method for carrying medicine aorta petal is prepared based on 3D printing and carries medicine aorta petal Download PDFInfo
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- CN106264791B CN106264791B CN201610649999.1A CN201610649999A CN106264791B CN 106264791 B CN106264791 B CN 106264791B CN 201610649999 A CN201610649999 A CN 201610649999A CN 106264791 B CN106264791 B CN 106264791B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y50/00—Data acquisition or data processing for additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
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- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a kind of prepared based on 3D printing to carry the method for medicine aorta petal and carries medicine aorta petal, solves to need long-term anticoagulant therapy and the bad technical problem of durability present in existing prosthetic valve replacement.Including：Obtain aorta petal medical image data；Aorta petal medical image data based on acquisition, establishes aorta petal threedimensional model；Based on aorta petal threedimensional model, 3D printing carries medicine aorta petal entity；Wherein, carrying medicine aorta petal entity includes annulus entity and leaflet entity；Carry medicine aorta petal entity leaflet physically, 3D printing has the drug-loaded layer of drug-loaded microporous structure；Using droplet ejection technology, anticoagulation is sprayed in the drug-loaded microporous structure of drug-loaded layer, and growth factor is sprayed in the region of the non-drug-loaded microporous structure of drug-loaded layer, is formed and carries medicine aorta petal.The aorta petal printed has drug slow release function, highly bionical, can improve biocompatibility.
Description
Technical field
The invention belongs to human body implanted medical device technical field, is to be related to one kind to prepare based on 3D printing specifically
Carry the method for medicine aorta petal and carry medicine aorta petal.
Background technology
Cardiac valves is to ensure that the critical biological valve of directed flow is capable of in blood circulation, its fine structure, possesses tune
The important physiological function in blood direction is penetrated in control, while flexible motion and bears the kinetic characters such as hydraulic pressure height.
Lesion once occurs for cardiac valves, will change human bloodstream, can threat to life when serious.Valvulopathy is mesh
One of preceding most common three big heart disease, wherein aortic valve disease are one kind of valvulopathy, and palpitaition, the heart can be caused to twist
The symptoms such as pain.
Aortic valve disease is mainly treated by prosthetic valve replacement at present.It is bioengineered tissue to build cardiac valves
And one of focus of regenerative medicine research.The replacement valve clinically used mainly has mechanical prosthetic valve and bioprosthetic valves, but two kinds of valves
The defects of in clinical practice all there is being difficult to overcome.Long-term use of anticoagulation is needed after mechanical prosthetic valve replacement heart valve, it is no
Thrombus and embolism then can be formed because anti-freezing is improper；Though durability be present not without long-term anticoagulant therapy after bioprosthetic valves implantation
Good problem, it is postoperative that thing valvular calcification easily occurs and decays, cause the valve of implantation to produce dysfunction, patient needs to be implanted into again
New valve.
The content of the invention
This application provides a kind of method and load medicine aorta petal that load medicine aorta petal is prepared based on 3D printing, solve existing
Having needs long-term anticoagulant therapy and the bad technical problem of durability present in prosthetic valve replacement.
In order to solve the above technical problems, the application is achieved using following technical scheme：
A kind of method for being prepared based on 3D printing and carrying medicine aorta petal is proposed, including：Obtain aorta petal medical image number
According to；Aorta petal medical image data based on acquisition, establishes aorta petal threedimensional model；Based on the aorta petal three-dimensional mould
Type, 3D printing carry medicine aorta petal entity；Wherein, the load medicine aorta petal entity includes annulus entity and leaflet entity；
Physically, 3D printing has the drug-loaded layer of drug-loaded microporous structure to the leaflet for carrying medicine aorta petal entity；Using droplet ejection
Technology, anticoagulation is sprayed in the drug-loaded microporous structure of the drug-loaded layer, and growth factor is sprayed in the drug-loaded layer
Non- drug-loaded microporous structure region, formed carry medicine aorta petal.
Further, after aorta petal medical image data is obtained, methods described also includes：According to aorta petal
It can analyze and obtain the gradient function analyze data of aorta petal；Before then 3D printing carries medicine aorta petal entity, methods described is also
Including：The aorta petal threedimensional model is layered, slicing treatment；By the gradient in the layering, slicing treatment
Functional analysis data are converted to the gray value of color；Gray value based on color, calculate and medicine aorta petal reality is carried described in 3D printing
The component ratio of the first printed material and the second printed material needed for body；Then the 3D printing carries medicine aorta petal entity, tool
Body is：First printed material and second printed material are controlled according to the component ratio output printing load medicine master
Arterial valve entity.
Further, first printed material and second printed material are that polyurethane and ethene-vinyl acetate are total to
Polymers.
Further, after aorta petal threedimensional model is established, methods described also includes：Based on contact mechanics, stress,
The analysis checking of hemodynamics and printing compatible degree, is modified to the aorta petal threedimensional model.
Further, the control first printed material and second printed material are defeated according to the component ratio
Go out, be specially：First printed material and second printed material is controlled to be exported according to the component ratio to blending room；
The heating-up temperature for controlling the blending room is 160 DEG C -250 DEG C, to change the viscosity of intermingling material；By the intermingling material after heating
By being extruded after screw extruding through printing head.
Further, using droplet ejection technology, anticoagulation is sprayed in the drug-loaded microporous structure of the drug-loaded layer,
And spray growth factor when the region of the non-drug-loaded microporous structure of the drug-loaded layer, control the growth factor not cover
The anticoagulation.
Further, the print thickness of the drug-loaded layer is 0.1mm-0.5mm.
Further, the drug-loaded microporous spacing structure is distributed in the drug-loaded layer；Printing is described to have load medicine micro-
During the drug-loaded layer of pore structure, the printing of the drug-loaded microporous structure is highly 0.2-0.9mm, thickness 0.1-0.3mm.
Further, the anticoagulation is warfarin, and the growth factor is fibroblast growth factor.
A kind of load medicine aorta petal is proposed, is prepared using the method that load medicine aorta petal is prepared based on 3D printing.Institute
Stating the method based on 3D printing preparation load medicine aorta petal includes：Obtain aorta petal medical image data；Master based on acquisition
Arterial valve medical image data, establish aorta petal threedimensional model；Based on the aorta petal threedimensional model, 3D printing carries medicine master
Arterial valve entity；Wherein, the load medicine aorta petal entity includes annulus entity and leaflet entity；In the load medicine aorta petal
Physically, 3D printing has the drug-loaded layer of drug-loaded microporous structure to the leaflet of entity；Using droplet ejection technology, anticoagulation is sprayed
The non-drug-loaded microporous structure in the drug-loaded layer is sprayed in the drug-loaded microporous structure of the drug-loaded layer, and by growth factor
Region, formed and carry medicine aorta petal.
Compared with prior art, the advantages of the application and good effect is：What the application proposed prepares load based on 3D printing
The method and load medicine aorta petal of medicine aorta petal, the load medicine of aortic valve replacement is printed for actively using 3D printing technique
Arteries and veins valve entity, and anticoagulant and Porcine HGF are ejected into respectively using piezoelectricity droplet electrojet technology and carry medicine actively
In the microcellular structure of the drug-loaded layer of arteries and veins valve entity and in the region surface of non-microcellular structure, finally obtain and carry medicine aorta petal；Carry
The drug-loaded layer of medicine aorta petal entity is printed by polyurethane and ethylene-vinyl acetate copolymer composite, and it is anti-to possess carrying
The microcellular structure of solidifying medicine, the anticoagulant in micropore can slowly discharge, and play the effect of anti-freezing；Load medicine beyond microcellular structure
The Porcine HGF of layer area spray, cell can be promoted to carry the growth of medicine aorta petal, improve biocompatibility；This its
In, also from bionical angle, with reference to the gradient analysis data to aorta petal, it is copolymerized by polyurethane and ethene-vinyl acetate
The load medicine aorta petal entity that thing different ratio makes to print has functionally gradient, more meets human physiological structure.The method system
The load medicine aorta petal of work has functionally gradient and drug slow release function concurrently, while can improve biocompatibility, highly bionical, solves
The problem of existing machinery valve long-term anti-freezing and bad bioprosthetic valves durability.And this preparation method can be quick by 3D printing
Shaping, possesses personalized bionical performance, and manufacturing process is simple, can reduce cost of manufacture.
After the detailed description of the application embodiment is read in conjunction with the figure, other features and advantage of the application will become more
Add clear.
Brief description of the drawings
Fig. 1 is the method flow diagram that load medicine aorta petal is prepared based on 3D printing that the application proposes；
Fig. 2 is the structure chart for the load medicine aorta petal that the application proposes；
Fig. 3 is the print structure figure for the load medicine aorta petal that the application proposes；
Fig. 4 is the printing equipment figure for the load medicine aorta petal entity that printing the application proposes.
Embodiment
The embodiment of the application is described in more detail below in conjunction with the accompanying drawings.
The application aims to provide a kind of method and load medicine aorta petal for being prepared based on 3D printing and carrying medicine aorta petal, solves
Long-term anticoagulant therapy and the bad technical problem of durability are needed present in existing prosthetic valve replacement.
As shown in figure 1, the method that load medicine aorta petal is prepared based on 3D printing that the application proposes, is comprised the following steps：
Step S11：Obtain aorta petal medical image data.
Substantial amounts of Healthy Volunteers aortic valve iconography data are gathered, build the statistics mould of aortic valve in normal
Type.
Step S12：Aorta petal medical image data based on acquisition, establishes aorta petal threedimensional model.
Intend the image processing techniques of implant structure Computer Aided Design by 3D, to intending 3D printing aortic valve according to symmetrical
Principle, normal configuration fitting theory carry out Computer Aided Design, obtain aorta petal threedimensional model.
Step S13：Based on aorta petal threedimensional model, 3D printing carries medicine aorta petal entity.
Printing is carrying medicine aorta petal entity as shown in Fig. 2 including annulus entity 21 and leaflet entity 22.Designing
After the threedimensional model of aorta petal, it is layered, slicing treatment, by being carried out to aorta petal threedimensional model file at layering
Reason, after having obtained each layer profile information to be filled, is filled, it is swept using the parallel shuttle-scanning mode of uninterrupted formula
Retouching the generating process in path includes following steps：Scan line determines；Scan line asks friendship with profile；Intersection point is classified and sequence；
Transition wire curve matching；Generate intersection point pairing；Store scan line.
The position that can also be associated to aorta petal carries out computer simulation contact mechanics, stress, hemodynamics and beaten
Compatible degree analysis checking is printed, threedimensional model is modified.
And then packet sequencing is carried out to the triangle surface of threedimensional model file, triangle surface be grouped matrix and
The foundation of active triangle surface table, in less scope, establish local triangle surface adjoining topological relation.
Step S14：State carry medicine aorta petal entity leaflet physically, 3D printing has the load medicine of drug-loaded microporous structure
Layer.
As shown in figure 3, leaflet is physically printed with the drug-loaded layer in drug-loaded microporous structure 32 using 3D printing technique
31。
Step S15：Using droplet ejection technology, anticoagulation is sprayed in the drug-loaded microporous structure of drug-loaded layer, and will
Growth factor is sprayed in the region of the non-drug-loaded microporous structure of drug-loaded layer, is formed and is carried medicine aorta petal.
Using droplet ejection technology, and anticoagulation 33 is ejected into by precise control system the drug-loaded microporous of drug-loaded layer 31
In structure 32, drug-loaded microporous spacing structure is distributed in drug-loaded layer.On drug-loaded layer 31 on the region of non-drug-loaded microporous structure
One layer of growth factor 34 of precise Printing is accurately sprayed using droplet ejection technology, but growth factor does not cover anticoagulant.Here
Anticoagulation be warfarin, growth factor is fibroblast growth factor.
It is above-mentioned, the load medicine aorta petal entity of aortic valve replacement is printed for using 3D printing technique, and use
Anticoagulant and Porcine HGF are ejected into the drug-loaded layer for carrying medicine aorta petal entity by piezoelectricity droplet electrojet technology respectively
Microcellular structure in and non-microcellular structure region surface on, finally obtain carry medicine aorta petal；Carry medicine aorta petal entity
Drug-loaded layer is printed by polyurethane and ethylene-vinyl acetate copolymer composite, possesses the microcellular structure of carrying anticoagulation, micro-
Anticoagulant in hole can slowly discharge, and play the effect of anti-freezing；The cell of drug-loaded layer area spray beyond microcellular structure
Growth factor, cell can be promoted to carry the growth of medicine aorta petal, improve biocompatibility, it is long-term to solve existing machinery valve
The problem of anti-freezing and bad bioprosthetic valves durability.
In the embodiment of the present application, possesses bionical performance in load medicine aorta petal for make to print, according to substantial amounts of normal
Volunteer's aorta petal iconography data, build the statistical models of normal human's aorta petal, analysis aorta petal difference portion
Bit architecture difference, aorta petal functionally gradient distributed data can be obtained, the load medicine active printed according to functionally gradient distribution
Arteries and veins valve entity has functionally gradient, more meets human physiological structure.
Specifically, after step S11 obtains aorta petal medical image data, obtained always according to aorta petal performance evaluation
To the gradient function analyze data of aorta petal；Based on this, gradient function analyze data is converted in layering, slicing treatment
The gray value of color；The gray value of color is then based on, 3D printing is calculated and carries medicine actively
The component ratio of the first printed material and the second printed material needed for arteries and veins valve entity；Medicine sustainer is carried in 3D printing
During valve entity, control the first printed material and the second printed material to export printing according to component ratio and carry medicine aorta petal entity.
Specifically, the first printed material and the second printed material as shown in figure 4, be loaded in two barrels 41 and 42 respectively
In, the first printed material and the second printed material here are polyurethane and ethylene-vinyl acetate copolymer, control first respectively
Printed material and the second printed material are exported to blending room 43 from the charging aperture of two barrels according to component ratio；Control blending room
Heating-up temperature be 160 DEG C -250 DEG C, to change the viscosity of intermingling material；Finally the intermingling material after heating is squeezed by screw rod
Extruded after pressure through printing head 44, successively print aorta petal annulus entity and leaflet entity.
It is above-mentioned, from bionical angle, with reference to the gradient analysis data to aorta petal, pass through polyurethane and ethyl vinyl acetate
The load medicine aorta petal entity that ethylene copolymer different ratio makes to print has functionally gradient, more meets human physiological structure,
So that carrying medicine aorta petal has functionally gradient and drug slow release function concurrently, while biocompatibility can be improved, it is highly bionical, and make
Personalized bionical performance can be possessed, and manufacturing process is simple, can reduce and be fabricated to by 3D printing rapid shaping by making method
This.
Based on the method set forth above for being prepared based on 3D printing and carrying medicine aorta petal, the application also proposes a kind of load medicine master
Arterial valve, prepared using the method that load medicine aorta petal is prepared based on 3D printing.
Described in detail below with a specific embodiment and prepare the method system for carrying medicine aorta petal using based on 3D printing
It is standby to carry medicine aorta petal.
Making material：The printed material that annulus entity and leaflet entity use is copolymerized for polyurethane and ethene-vinyl acetate
Thing, polyurethane component ratio are 20%-98%, and corresponding ethylene-vinyl acetate copolymer ratio is 80%-2%.
Drug-loaded microporous structural material on the drug-loaded layer of leaflet is polyurethane and ethylene-vinyl acetate copolymer composite
Polyurethane component ratio 20%-98%, corresponding ethylene-vinyl acetate copolymer ratio 80%-2%.
The drug-loaded layer anticoagulant of leaflet uses warfarin, drug-loaded layer thickness 0.1-0.5mm；Leaflet growth factor layer grows
The factor uses fibroblast growth factor, growth factor thickness degree 0.1-0.3mm.
Print specifications：Aorta petal integrative-structure, annulus are circular configuration, and three leaflets are located at irregular three inside annulus
Angular structure.Mm-the 15mm of annulus wall thickness 1, the mm -38mm of internal diameter 10.Leaflet thickness 2-15mm, leaflet length 4mm-19 mm.
Drug-loaded microporous the structure height 0.2-0.9mm, thickness 0.1-0.3mm being spaced apart in drug-loaded layer.
Carry the shaping of medicine aorta petal：Annulus entity and leaflet physical layer 3D printing are integrally formed.Physical print is based on function
Gradient is carried out, printing head pressure 50-600kPa, 50-200 μm of nozzle diameter.Leaflet physically prints drug-loaded layer and carries medicine
Microcellular structure is used to load anticoagulant and growth factor, printing head pressure 180kPa, 100 μm of jet diameters.Anticoagulant
By accurately controlling piezoelectricity microsphere sprayer head to spurt into anticoagulation in drug-loaded microporous structure；Growth factor is by accurately controlling piezoelectricity
Microsphere sprayer head spurts into fibroblast growth factor in the region of the non-drug-loaded microporous structure of drug-loaded layer, ensures growth factor not
Cover anticoagulant.Piezoelectricity droplet ejection pressure 10-200kPa, 80-120 μm of jet diameters.
It should be noted that it is limitation of the present invention that described above, which is not, the present invention is also not limited to the example above,
The variations, modifications, additions or substitutions that those skilled in the art are made in the essential scope of the present invention, also should
Belong to protection scope of the present invention.
Claims (10)
1. the method for carrying medicine aorta petal is prepared based on 3D printing, it is characterised in that including：
Obtain aorta petal medical image data；
Aorta petal medical image data based on acquisition, establishes aorta petal threedimensional model；
Based on the aorta petal threedimensional model, 3D printing carries medicine aorta petal entity；Wherein, the load medicine aorta petal entity
Including annulus entity and leaflet entity；
In the leaflet for carrying medicine aorta petal entity physically, 3D printing has the drug-loaded layer of drug-loaded microporous structure；
Using droplet ejection technology, anticoagulation is sprayed in the drug-loaded microporous structure of the drug-loaded layer, and by growth factor
Spray in the region of the non-drug-loaded microporous structure of the drug-loaded layer, formed and carry medicine aorta petal.
2. according to claim 1 prepare the method for carrying medicine aorta petal based on 3D printing, it is characterised in that is led obtaining
After arterial valve medical image data, methods described also includes：
The gradient function analyze data of aorta petal is obtained according to aorta petal performance evaluation；
Before then 3D printing carries medicine aorta petal entity, methods described also includes：
The aorta petal threedimensional model is layered, slicing treatment；
The gradient function analyze data is converted to the gray value of color in the layering, slicing treatment；
Gray value based on color, calculate the first printed material described in 3D printing needed for load medicine aorta petal entity and second dozen
Print the component ratio of material；
Then the 3D printing carries medicine aorta petal entity, is specially：Control first printed material and the second printing material
Material is according to the component ratio output printing load medicine aorta petal entity.
3. according to claim 2 prepare the method for carrying medicine aorta petal based on 3D printing, it is characterised in that described the
One printed material and second printed material are polyurethane and ethylene-vinyl acetate copolymer.
4. according to claim 1 prepare the method for carrying medicine aorta petal based on 3D printing, it is characterised in that is led establishing
After arterial valve threedimensional model, methods described also includes：
Based on contact mechanics, stress, hemodynamics and the analysis checking for printing compatible degree, the aorta petal threedimensional model is entered
Row amendment.
5. according to claim 2 prepare the method for carrying medicine aorta petal based on 3D printing, it is characterised in that the control
First printed material and second printed material export according to the component ratio, are specially：
First printed material and second printed material is controlled to be exported according to the component ratio to blending room；
The heating-up temperature for controlling the blending room is 160 DEG C -250 DEG C, to change the viscosity of intermingling material；
By the intermingling material after heating by being extruded after screw extruding through printing head.
6. according to claim 1 prepare the method for carrying medicine aorta petal based on 3D printing, it is characterised in that using micro-
Spraying technique is dripped, anticoagulation is sprayed in the drug-loaded microporous structure of the drug-loaded layer, and growth factor is sprayed in described
During the region of the non-drug-loaded microporous structure of drug-loaded layer, the growth factor is controlled not cover the anticoagulation.
7. according to claim 1 prepare the method for carrying medicine aorta petal based on 3D printing, it is characterised in that the load medicine
The print thickness of layer is 0.1mm-0.5mm.
8. according to claim 1 prepare the method for carrying medicine aorta petal based on 3D printing, it is characterised in that the load medicine
Microcellular structure interval is distributed in the drug-loaded layer；When there is the drug-loaded layer of drug-loaded microporous structure described in printing, the load medicine
The printing of microcellular structure is highly 0.2-0.9mm, thickness 0.1-0.3mm.
9. according to claim 1 prepare the method for carrying medicine aorta petal based on 3D printing, it is characterised in that the anti-freezing
Medicine is warfarin, and the growth factor is fibroblast growth factor.
10. one kind carries medicine aorta petal, it is characterised in that using as described in any one of the claim 1-9 claim based on
The method that 3D printing prepares load medicine aorta petal is prepared.
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| CN106726009A (en) * | 2017-03-06 | 2017-05-31 | 董念国 | Sustainer intervenes valve manufacture method |
| CN109481085A (en) * | 2018-12-25 | 2019-03-19 | 天津市胸科医院 | A kind of intervention valve being applied with drug |
| CN111284000A (en) * | 2020-02-20 | 2020-06-16 | 清华大学 | Medicine-carrying heart valve based on biological 3D printing and manufacturing method thereof |
| CN113101014B (en) * | 2021-04-21 | 2022-07-01 | 山东大学 | Manufacturing method of artificial heart valve stent |
| CN114041905A (en) * | 2021-10-08 | 2022-02-15 | 吉林大学 | Acetabulum periphery bone integration bionic acetabulum reconstruction prosthesis and design method thereof |
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| CN102886076B (en) * | 2012-09-27 | 2017-03-22 | 深圳清华大学研究院 | Bone repair porous bracket and rapid forming method |
| CN102860890B (en) * | 2012-10-14 | 2014-12-17 | 梁春永 | Composite medicine carrying vessel stent and preparation method thereof |
| DE102013103499A1 (en) * | 2013-04-08 | 2014-10-09 | Phitea GmbH | Flexible woven adjustable cavity support |
| US10409235B2 (en) * | 2014-11-12 | 2019-09-10 | Siemens Healthcare Gmbh | Semantic medical image to 3D print of anatomic structure |
| CN104667345B (en) * | 2015-01-30 | 2017-02-22 | 深圳迈普再生医学科技有限公司 | Cranioplasty prosthesis with biological activity and preparation method of cranioplasty prosthesis |
| CN105031718B (en) * | 2015-08-27 | 2018-04-13 | 华南理工大学 | Bone repair porous composite scaffold based on 3D-Bioplotter printing technology and preparation method thereof |
| CN105415687B (en) * | 2015-12-22 | 2018-04-27 | 吉林大学 | A kind of Alternative 3D printing method |
| CN105435308B (en) * | 2015-12-23 | 2018-10-26 | 天津幂方科技有限公司 | A kind of breast prosthetic implant three-dimensional structure and its quick forming method |
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