CN106264513A - External counterpulsation technology is utilized to evaluate the method and system of cerebral-vessel imaging function - Google Patents
External counterpulsation technology is utilized to evaluate the method and system of cerebral-vessel imaging function Download PDFInfo
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Abstract
This application provides the method evaluating individual cerebral-vessel imaging function, comprise the following steps: a) the described individual external counterpulsation that applies is operated；B), before counterpulsation operates in vitro, during external counterpulsation operation and after external counterpulsation operation, described individuality is carried out seriality monitoring of blood pressure and cerebral blood flow velocity monitoring；And c) record blood pressure change that described individual response operates in external counterpulsation and cerebral blood flow velocity changes, and evaluate the cerebral-vessel imaging function of described individuality based on this.Present invention also provides the system implementing described method.
Description
Technical field
The application relates generally to medical field.More specifically, this application provides utilize external
Counterpulsation technology evaluates the method and system of cerebral-vessel imaging function.
Background of invention
External counterpulsation (External counterpulsation, ECP) is a kind of noninvasive in order to increase organ
The method of blood perfusion, its effect in terms for the treatment of has obtained the confirmation of Study of evidence based medicine.Mesh
Before, external counterpulsation has been included in treatment ischemic heart by China, the U.S. and some European countries the most
Sick treatment guidelines.Present inventor has carried out external counterpulsation treatment cerebral infarction
Test, and confirm that it can improve the clinical prognosis of acute stroke patients.
Cerebral-vessel imaging (Cerebral autoregulation, CA) ability refers to normal condition hypencephalon
Blood vessel possesses the ability maintaining cerebral blood flow relative constancy in certain blood pressure range.At present, comment
Valency cerebral-vessel imaging method mainly includes that blood pressure is automatically adjusted and cerebrovascular motor reaction
(cerebrovascular reactivity, CR) two aspects.Wherein, blood pressure is automatically adjusted and includes static regulation
(static CA, sCA) and dynamically regulation (dynamic CA, dCA) two kinds of appraisal procedures: the former is first
Measure basis arteriotony and cerebral blood flow velocity, after using such as vaso-excitor material thing, measure blood pressure and adjust
Arteriotony after control and cerebral blood flow velocity；The latter exits suddenly after then using burst blood pressure cuff inflation,
Utilize the change of TCD dynamic monitoring cerebral blood flow velocity, compare arteriotony and cerebral blood flow blood pressure.
Above appraisal procedure needs the general status of patient good.But, for such as suffering from brain diseases (example
As, apoplexy or cerebral trauma) patient, the application of above appraisal procedure will be restricted.And thing
Often with greater need for this type of patient being made commenting of timely, correct cerebral-vessel imaging function in reality
Valency.
New application outside exploitation external counterpulsation wipes out and treat insect pests and plant diseases treatment functions in medical domain is promising,
Simultaneously also a need in the art for the new method and system evaluating cerebral-vessel imaging function.
Summary of the invention
First aspect, this application provides the method evaluating individual cerebral-vessel imaging function, bag
Include following steps:
A) the described individual external counterpulsation that applies is operated；
B) before counterpulsation operates in vitro, during external counterpulsation operation and after external counterpulsation operation, right
Described individuality carries out seriality monitoring of blood pressure and cerebral blood flow velocity monitoring；And
C) record blood pressure change that described individual response operates in external counterpulsation and cerebral blood flow velocity changes
Become, and evaluate the cerebral-vessel imaging function of described individuality based on this.
In some embodiments, individuality is brain diseases patient.
In some embodiments, individuality is patients with cerebral injury or patients with cerebral apoplexy.
In some embodiments, individuality is acute stroke patients.
In some embodiments, individuality is the patient without clear-headed consciousness.
In some embodiments, external counterpulsation operation includes: at the diastole initial stage to individuality
Limbs portion adds malleation, and releases pressurization at end diastole.
In some embodiments, limbs are lower limb.
In some embodiments, pressurized portion is shank, thigh and/or buttocks.
In some embodiments, make to add malleation triggering Tong Bu with R ripple by electrocardiogram monitoring.
In some embodiments, the malleation applied is 0.02-0.04Mpa.
In some embodiments, adding malleation step is to connect according to shank, thigh, the order of buttocks
Continue and pressurize successively.
In some embodiments, seriality monitoring of blood pressure is based on volume-compensation method.
In some embodiments, cerebral blood flow velocity monitoring is based on Doppler Sonography, such as through cranium
Doppler Sonography.
In some embodiments, if the cerebral blood flow velocity of individuality is not with in response to external counterpulsation
Arteriotony is changed significantly and changes and keep or close to baseline values, it indicates that individual cerebral blood flow is certainly
Dynamic regulatory function is normal.
In some embodiments, if the cerebral blood flow velocity of individuality is with moving in response to external counterpulsation
Arteries and veins blood pressure increases and significantly changes, such as basic with blood pressure synchronous change, it indicates that individual
Cerebral-vessel imaging function is impaired.
Second aspect, this application provides for evaluate individual cerebral-vessel imaging function and is
System, comprising:
External counterpulsation apparatus, it is configured to be enough in and applies external counterpulsation operation to individuality；With
Monitoring device, it is configured to be enough in and individuality carries out seriality monitoring of blood pressure and brain blood
Flow Velocity is monitored.
In some embodiments, system also includes analytical equipment, its be configured to based on from
Blood pressure change that the data analysis individual response that monitoring device obtains operates in external counterpulsation and cerebral blood flow
Rapid change.
In some embodiments, system also includes evaluating apparatus, its be configured to based on from
Blood pressure change and cerebral blood flow velocity that analytical equipment obtains change the cerebral-vessel imaging evaluating individuality
Function.
In some embodiments, analytical equipment and/or evaluating apparatus are integrated in prison as functional module
Survey in device.
In some embodiments, external counterpulsation apparatus includes can putting on outside individual limbs
Capsule and being configured to makes described capsule expand or the pressure control device of emptying.
In some embodiments, external counterpulsation apparatus also includes electrocardiograph monitoring device.
In some embodiments, the device for seriality monitoring of blood pressure is based on cubage compensation
Method.
In some embodiments, the device for cerebral blood flow velocity monitoring is Doppler Sonography instrument,
Such as through cranium Doppler Sonography instrument.
In some embodiments, if the cerebral blood flow velocity of individuality is not with in response to external counterpulsation
Arteriotony is changed significantly and changes and keep or close to baseline values, it indicates that individual cerebral blood flow is certainly
Dynamic regulatory function is normal.
In some embodiments, if the cerebral blood flow velocity of individuality is with moving in response to external counterpulsation
Arteries and veins blood pressure increases and significantly changes, such as basic with blood pressure synchronous change, it indicates that individual
Cerebral-vessel imaging function is impaired.
Accompanying drawing explanation
Some specific embodiments of the application are embodied in accompanying drawing, wherein:
Fig. 1 illustrates exemplary operation principle and the equipment of external counterpulsation technology；
Fig. 2 illustrates the example devices for seriality monitoring of blood pressure and use state；
Fig. 3 illustrates the example devices for cerebral blood flow velocity monitoring；
Fig. 4 illustrates the exemplary operation state of the present processes and system；
Fig. 5 illustrates in an exemplary embodiment, normal healthy controls patient and patients with cerebral apoplexy
Arteriotony (mm Hg) is for the response of external counterpulsation.
Fig. 6 illustrates in an exemplary embodiment, normal healthy controls patient and patients with cerebral apoplexy (bag
Include focus bilateral) cerebral blood flow velocity (cm/s) for the response of external counterpulsation.
Fig. 7 illustrates in an exemplary embodiment, and patients with cerebral apoplexy is in response to the blood of external counterpulsation
The graph of a relation that pressure and cerebral blood flow velocity change.
Detailed description of the invention
In order to show feature and the advantage of the application further, below to some specific embodiments
It is described.Should be appreciated that following description is for illustration purposes only, and be not with any side
Formula is any limitation as.It is also understood that the technical characteristic combining the description of a certain embodiment is also applied for
Other embodiments, and can combine one with the technical characteristic combining the description of other embodiments
Rise, unless otherwise mentioned or can be made other from context and judge.
As described in " background of invention " part, current existing evaluation cerebral-vessel imaging function
Method, such as static regulation (static CA, sCA) and dynamically regulation (dynamic CA, dCA),
Application under the conditions of some can be restricted.Such as, such method be directed to use with vaso-excitor material thing,
CO2Or stock blood pressure cuff etc., this may reduce brain blood perfusion, then for such as apoplexy
Or the crowd of the brain disorder such as cerebral trauma, implement such test and can produce greater risk.
For such technical problem, external counterpulsation technology is innovatively introduced by present inventor
In the evaluation of cerebral-vessel imaging function, thus complete every invention of the application, its advantage
One or more including in following:
(1) non-invasive operation, safety and compliance are good；
(2) cerebral blood perfusion is not reduced, it is provided that brain is protected；
(3) individual test subjects is required low, it is not necessary to carry out too much cooperating with on one's own initiative.
First aspect, this application provides the method evaluating individual cerebral-vessel imaging function, bag
Include following steps:
A) the described individual external counterpulsation that applies is operated；
B) before counterpulsation operates in vitro, during external counterpulsation operation and after external counterpulsation operation, right
Described individuality carries out seriality monitoring of blood pressure and cerebral blood flow velocity monitoring；And
C) record blood pressure change that described individual response operates in external counterpulsation and cerebral blood flow velocity changes
Become, and evaluate the cerebral-vessel imaging function of described individuality based on this.
In some embodiments, external counterpulsation operation includes: at the diastole initial stage to individuality
Limbs portion adds malleation, and releases pressurization at end diastole.In some embodiments,
Limbs are lower limb.In some embodiments, pressurized portion is shank, thigh and/or buttocks.?
In some embodiments, make to add malleation triggering Tong Bu with R ripple by electrocardiogram monitoring.Real at some
Executing in scheme, the malleation applied is 0.02-0.04Mpa.In some embodiments, just add
Pressure step is to pressurize the most successively according to shank, thigh, the order of buttocks.
Fig. 1 illustrates exemplary operation principle and the equipment of external counterpulsation technology.Photo in Fig. 1
Show the equipment of external counterpulsation technology, mainly include platform and the electrocardioscanner couched for individuality,
The air bag of thigh, shank and the buttocks that can put on individuality, air bag and electromagnetism it is provided with on platform
Valve and gas tank communicate, and are inflated air bag mechanically and aerofluxus.In Fig. 1 two of upper left
Figure describes the working method of air bag, wherein at the diastole initial stage, according to shank to thigh to buttocks
The order in portion, pressurizes to air bag successively, is then emptied by air bag at end diastole simultaneously
Decompression.The waveform below electrocardiogram in Fig. 1 refers to that arteries and veins monitors external counterpulsation treatment waveform, arrow
Represent and start to start external counterpulsation treatment at diastole.
As nonrestrictive example, the external counterpulsation technology utilizing the equipment in Fig. 1 can be as follows
Implement:
Make experimenter lie low on platform, tie up with air bag at its thigh, shank and buttocks, work as heart
During diastole, synchronize to trigger by ecg-r wave, make to be centered around the airbag aeration of leg and buttocks, right
Limbs add malleation 0.02～0.04MPa, the diastole initial stage in turn stress on shank, thigh and
Buttocks, produces relaxing period supercharging ripple (diastolic augmentation, DA), releases in diastasis
All pressure, to drive blood to aortic regurgitation, stay the lower limb vascular bed of sky to accept the heart simultaneously
Dirty output, thus unloading after-contraction pressure (systolic unloading, SU) and cardiac afterload
(cardiac afterload) is minimized.In vitro during counterpulsation, double pulsatile blood flows are unique blood
Hydromechanics feature, can improve mean arterial pressure, increases the hemoperfusion of histoorgan, simultaneously
Also improve blood flow shearing stress.
In some embodiments, seriality monitoring of blood pressure is based on volume-compensation method.This type sets
For utilizing volume-compensation method to realize non-invasive blood pressure measure continuously, it is technically based on working as arterial blood
When pipe is in load condition due to External Force Acting, impressed pressure is equal to arterial pressure, blood vessel diameter
Will not change with fluctuation of blood pressure, blood vessel is in constant volume state.Utilizing volume-compensation method even
During continuous measurement blood pressure, in certain scope, change arteriotony, the amplitude of pulse can be measured simultaneously
Change with blood pressure.Exemplary continuous blood pressure monitoring equipment is as shown in Figure 2.
In some embodiments, cerebral blood flow velocity monitoring is based on Doppler Sonography, such as through cranium
Doppler Sonography.It is commonly used in the art monitoring for cerebral blood flow velocity through cranium Doppler Sonography
Equipment, its operation principle is as known in the art.Further, through cranium Doppler Sonography instrument and its
He can be used for the equipment commercially existing ripe product of cerebral blood flow velocity monitoring, and exemplary sets
For as shown in Figure 3.
In some embodiments, monitoring of blood pressure and cerebral blood flow velocity are monitored through external counterpulsation
All the time.In particular embodiments, counterpulsation can be recorded and start front baseline values, counterpulsation process
In, counterpulsation terminates blood pressure and the cerebral blood flow velocity of latter 1-5 minute.Fig. 4 illustrates the present processes
Exemplary operation state with system.
Before operating according to external counterpulsation, during external counterpulsation operation and after external counterpulsation operation, right
Described individuality carries out the data obtained by seriality blood pressure and cerebral blood flow velocity monitoring, can analyze
Go out the individual blood pressure in response to external counterpulsation operation and cerebral blood flow velocity change, according to these data then
Individual cerebral-vessel imaging function can be made an appraisal.
In some embodiments, if the cerebral blood flow velocity of individuality is not with in response to external counterpulsation
Arteriotony is changed significantly and changes and keep or close to baseline values, it indicates that individual cerebral blood flow is certainly
Dynamic regulatory function is normal.For the normally functioning individuality of cerebral-vessel imaging, tremulous pulse
Blood pressure can have the rising of certain amplitude due to external counterpulsation operation, but cerebral blood flow velocity can't
Therefore suffer from significantly affecting.
In some embodiments, if the cerebral blood flow velocity of individuality is with moving in response to external counterpulsation
Arteries and veins blood pressure increases and significantly changes, such as basic with blood pressure synchronous change, it indicates that individual
Cerebral-vessel imaging function is impaired.Such as, individuality parafunctional for cerebral-vessel imaging
For, arteriotony can have the rising of certain amplitude due to external counterpulsation operation, cerebral blood flow simultaneously
Speed can raise along with arteriotony and essentially simultaneously raise.
Additionally, inventors herein have recognized that, the change symbol of the individual blood pressure that external counterpulsation is caused
Close the blood pressure scope that normal cerebral-vessel imaging function can regulate and control, thus external counterpulsation
Be suitable for evaluate cerebral-vessel imaging function, this be also the application technology design a part.
Second aspect, this application provides for evaluate individual cerebral-vessel imaging function and is
System, comprising:
External counterpulsation apparatus, it is configured to be enough in and applies external counterpulsation operation to individuality；With
Monitoring device, it is configured to be enough in and individuality carries out seriality monitoring of blood pressure and brain blood
Flow Velocity is monitored.
In some embodiments, system also includes analytical equipment, its be configured to based on from
Blood pressure change that the data analysis individual response that monitoring device obtains operates in external counterpulsation and cerebral blood flow
Rapid change.
In some embodiments, system also includes evaluating apparatus, its be configured to based on from
Blood pressure change and cerebral blood flow velocity that analytical equipment obtains change the cerebral-vessel imaging evaluating individuality
Function.
Should be appreciated that above-mentioned analytical equipment and evaluating apparatus are not necessary to the system of the application.
Such as, analysis process can complete by means of single computer, and evaluation procedure can also be by
Physician in view analysis result artificially judges.In some embodiments, for the integration of system
Property and the purpose of ease of use, be integrated in analytical equipment and/or evaluating apparatus as functional module
In monitoring device.
In some embodiments, external counterpulsation apparatus includes can putting on outside individual limbs
Capsule and being configured to makes described capsule expand or the pressure control device of emptying.
In some embodiments, external counterpulsation apparatus also includes electrocardiograph monitoring device.
In some embodiments, the device for seriality monitoring of blood pressure is based on cubage compensation
Method.
In some embodiments, the device for cerebral blood flow velocity monitoring is Doppler Sonography instrument,
Such as through cranium Doppler Sonography instrument.
In some embodiments, if the cerebral blood flow velocity of individuality is not with in response to external counterpulsation
Arteriotony is changed significantly and changes and keep or close to baseline values, it indicates that individual cerebral blood flow is certainly
Dynamic regulatory function is normal.
In some embodiments, if the cerebral blood flow velocity of individuality is with moving in response to external counterpulsation
Arteries and veins blood pressure increases and significantly changes, such as basic with blood pressure synchronous change, it indicates that individual
Cerebral-vessel imaging function is impaired.
External counterpulsation apparatus mentioned above and the operation principle of monitoring device are those skilled in the art
Known, and the most all have commercially produced product to sell at present.By reading the public affairs of the application
Open content, it will be appreciated by those skilled in the art that the enforcement of every invention of the application is not relying on
In certain types of external counterpulsation apparatus and monitoring device, and it is critical only that by external counterpulsation technology with
Seriality monitoring of blood pressure and cerebral blood flow velocity monitoring combine adjusts automatically for evaluating individual cerebral blood flow
Joint function.Therefore, various types of external counterpulsation apparatus and monitoring device can be applied well
In the application.
Embodiment
Research individuality
Recruitment standard: with the narrow and good temporo window of intracranial vessel, and in morbidity 7 days
Patients with acute ischemic cerebral stroke.
Exclusion standard: the heart source property apoplexy caused by atrial fibrillation and valvular heart disease；Warp
The cerebral hemorrhage that brain CT confirms；Arteriovenous malformotion, arteriovenous fistula and aneurysm；Hypertension (is shunk
Pressure > 180mm Hg or diastolic pressure > 100mm Hg)；Serious symptomatic peripheral angiopathy；Both
Toward having cerebral hemorrhage or malignant tumor history；And the evidence of the systemic disease deposited such as renal failure (flesh
Acid anhydride>300mmol/L), thrombocytopenia (platelet count<100000/mm3)；Dementia and bosom
Pregnant.
Simultaneously recruit the age more than 45 years old without cardiovascular and cerebrovascular disease and the healthy will of any risk factor
Hope person does matched group.
This research obtains the approval of ethics committee, and participates in patient and the health of this research
Comparison individuality all endorsed Written informed consent.
Experimental facilities and method
External counterpulsation equipment: (China's Foshan City's Chinese Medical Instruments is limited for external counterpulsation MC3 model
Company), processing pressure scope 150mm Hg-262.5mm Hg.
Cerebral blood flow velocity monitoring device: TCD monitoring uses ST3TCD system
(Spencer Technologies,Seattle,WA)。
Seriality blood pressure monitoring device: Task Force Monitor 3040i instrument (CNSystems
Medizintechnik AG, Graz, Austria).
Experimenter's (including patients with cerebral apoplexy and comparison individuality) is made to lie on external counterpulsation treatment bed, at it
Thigh, shank and buttocks are tied up with counterpulsation equipment air bag, by two 2-MHz ultrasonic Doppler transducer peaces
Being contained on the fixable helmet, the bilateral temporo window 50-65mm degree of depth patient searches middle cerebral artery
M1 section, and seriality blood pressure monitoring device is connected on experimenter.
When diastole, synchronize to trigger by ecg-r wave, make to be centered around the gas of leg and buttocks
Capsule is inflated, and limbs adds 150mmHg (～0.02MPa) malleation, in turn adds at the diastole initial stage
It is pressed on shank, thigh and buttocks, produces relaxing period supercharging ripple (diastolic augmentation, DA),
Release all pressure in diastasis, to drive blood to aortic regurgitation, stay under sky simultaneously
Limb vascular bed accepts cardiac output, thus unloading after-contraction pressure (systolic unloading, SU) and
Cardiac afterload (cardiac afterload) is minimized.
Monitoring external counterpulsation treatment before baseline, external counterpulsation process time and external counterpulsation treatment after bilateral
Middle cerebral artery cerebral blood flow velocity value, each period monitors 3 minutes respectively；Meanwhile, continuous record
Pressure value.
Fig. 5 and Fig. 6 shows that the external counterpulsation startup mean arterial pressure value of latter 3 minutes and brain move
Normal pulse equal cerebral blood flow velocity value.As it is shown in figure 5, through external counterpulsation process after, apoplexy patient and
The mean arterial pressure of normal healthy controls person all has and raises responsively.Visible by Fig. 6, for apoplexy
Patient, external counterpulsation processes and causes the average cerebral blood flow velocity of apoplexy stove homonymy and apoplexy stove offside equal
Occur；By contrast, external counterpulsation processes the average cerebral blood flow velocity for normal healthy controls person does not has
Impact, the average cerebral blood flow velocity after external counterpulsation processes remains at baseline values.
Mean arterial pressure that apoplexy patient processes in response to external counterpulsation and the change of average cerebral blood flow velocity
Change graph of a relation to be showed in further in Fig. 7.As it is shown in fig. 7, for apoplexy patient, its in response to
External counterpulsation process mean arterial pressure change and average cerebral blood flow velocity (include apoplexy stove homonymy and in
Wind stove offside) change and substantially synchronize, and trend is close, and this shows in these patients,
Cerebrovascular maintain in certain blood pressure range cerebral blood flow relative constancy ability (that is, cerebral blood flow from
Dynamic regulating power) receive destruction.By contrast, as described above, external counterpulsation processes for strong
The average cerebral blood flow velocity of health collator does not affect.
By above-mentioned it is experimentally confirmed that the provided herein external counterpulsation technology that utilizes evaluates cerebral blood flow
The method and system of automatic regulation function is successful.
It will be appreciated by those skilled in the art that in the case of without departing from the spirit and scope of the application,
The embodiment described herein can be changed and changes, or with in other pertinent literature
Technical scheme or technical characteristic are combined, thus obtain other technical scheme, and these schemes are also
Including within the scope of the present application.In detail in the claims, the term used should not be construed
For claim being limited to the detailed description of the invention disclosed in present specification and claims, and
Complete together with the equivalent required by claim of all possible embodiment should be interpreted as including
Portion's scope.Therefore, claim is not limited by the disclosure.
Claims (10)
1. the method evaluating individual cerebral-vessel imaging function, comprises the following steps:
A) the described individual external counterpulsation that applies is operated；
B) before counterpulsation operates in vitro, during external counterpulsation operation and after external counterpulsation operation, right
Described individuality carries out seriality monitoring of blood pressure and cerebral blood flow velocity monitoring；And
C) record blood pressure change that described individual response operates in external counterpulsation and cerebral blood flow velocity changes
Become, and evaluate the cerebral-vessel imaging function of described individuality based on this.
2. the method for claim 1, wherein said individuality is brain diseases patient, appoints
Selection of land is patients with cerebral injury or patients with cerebral apoplexy, such as acute stroke patients.
3. method as claimed in claim 1 or 2, the operation of wherein said external counterpulsation includes:
Malleation is added to the limbs portion of described individuality at the diastole initial stage, and at end diastole
Release and pressurize, the most optionally,
Described limbs are lower limb；And/or
Make to add malleation triggering Tong Bu with R ripple by electrocardiogram monitoring；And/or
Described malleation is 0.02-0.04Mpa；And/or
The described malleation step that adds is to pressurize the most successively according to shank, thigh, the order of buttocks.
4. the method as according to any one of claim 1-3, wherein
Described seriality monitoring of blood pressure is based on volume-compensation method, and/or
The monitoring of described cerebral blood flow velocity is based on through cranium Doppler Sonography.
5. the method as according to any one of claim 1-4, if the cerebral blood flow of wherein individuality
Speed is not changed significantly with the arteriotony in response to external counterpulsation and changes and keep or close to baseline water
Flat, it indicates that individual cerebral-vessel imaging function is normal；If the cerebral blood flow velocity of individuality with
Arteriotony in response to external counterpulsation increases and significantly changes, and such as substantially synchronizes with blood pressure
Change, it indicates that individual cerebral-vessel imaging function is impaired.
6. for evaluating the system of individual cerebral-vessel imaging function, comprising:
External counterpulsation apparatus, it is configured to be enough in and applies external counterpulsation operation to individuality；With
Monitoring device, it is configured to be enough in and individuality carries out seriality monitoring of blood pressure and brain blood
Flow Velocity is monitored.
7. system as claimed in claim 6, also includes analytical equipment, and it is configured to base
In the blood pressure change that the data analysis individual response obtained from described monitoring device operates in external counterpulsation
Change with cerebral blood flow velocity.
8. system as claimed in claim 7, also includes evaluating apparatus, and it is configured to base
Change in the blood pressure change obtained from described analytical equipment and cerebral blood flow velocity and evaluate individual cerebral blood flow
Automatic regulation function, the most optionally,
Described analytical equipment and/or described evaluating apparatus are integrated in described monitoring device as functional module
In.
9. the system as according to any one of claim 6-8, wherein said external counterpulsation apparatus bag
Include and can put on individual capsule limbs outside and be configured to make described capsule expand or empty
Pressure control device, the most optionally,
Described external counterpulsation apparatus also includes electrocardiograph monitoring device.
10. the system as according to any one of claim 6-9, wherein
Device for seriality monitoring of blood pressure is based on volume-compensation method；And/or
Device for cerebral blood flow velocity monitoring is through cranium Doppler Sonography instrument.
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| CN110384485A (en) * | 2019-07-23 | 2019-10-29 | 中山大学附属第八医院（深圳福田） | The detection method and device that body haemodynamics responds in external counterpulsation treatment |
| CN110495864A (en) * | 2019-08-02 | 2019-11-26 | 深圳市德胜医疗科技有限公司 | Human vas blood flow convergent force and Diastolic Force measuring method and device |
| CN111048203A (en) * | 2019-11-22 | 2020-04-21 | 中国科学院深圳先进技术研究院 | Brain blood flow regulator evaluation device |
| CN112754521A (en) * | 2021-01-12 | 2021-05-07 | 上海交通大学 | Method and system for evaluating brain blood flow automatic regulation capability |
| CN113925484A (en) * | 2021-09-26 | 2022-01-14 | 深圳市千帆电子有限公司 | Method and system for measuring blood flow dynamics |
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| WENHUA LIN等: ""External Counterpulsation Augments Blood Pressure and Cerebral Flow Velocities in Ischemic Stroke Patients With Cerebral Intracranial Large Artery Occlusive Disease"", 《STROKE》 * |
| 林文华等: "体外反搏治疗的脑血流增益作用与缺血性脑卒中患者", 《中华医学会第十七次全国神经病学术会议》 * |
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| CN109771245A (en) * | 2019-02-18 | 2019-05-21 | 中山大学附属第一医院 | The method and system of individual function of vascular endothelium is evaluated using external counterpulsation technology |
| CN110384485A (en) * | 2019-07-23 | 2019-10-29 | 中山大学附属第八医院（深圳福田） | The detection method and device that body haemodynamics responds in external counterpulsation treatment |
| CN110495864A (en) * | 2019-08-02 | 2019-11-26 | 深圳市德胜医疗科技有限公司 | Human vas blood flow convergent force and Diastolic Force measuring method and device |
| CN110495864B (en) * | 2019-08-02 | 2022-04-05 | 深圳市德胜医疗科技有限公司 | Method and device for measuring human blood vessel blood flow contraction force and relaxation force |
| CN111048203A (en) * | 2019-11-22 | 2020-04-21 | 中国科学院深圳先进技术研究院 | Brain blood flow regulator evaluation device |
| CN111048203B (en) * | 2019-11-22 | 2020-11-27 | 中国科学院深圳先进技术研究院 | Brain blood flow regulator evaluation device |
| CN112754521A (en) * | 2021-01-12 | 2021-05-07 | 上海交通大学 | Method and system for evaluating brain blood flow automatic regulation capability |
| CN113925484A (en) * | 2021-09-26 | 2022-01-14 | 深圳市千帆电子有限公司 | Method and system for measuring blood flow dynamics |
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