CN106262638A - A kind of flavouring agent - Google Patents
A kind of flavouring agent Download PDFInfo
- Publication number
- CN106262638A CN106262638A CN201610624900.2A CN201610624900A CN106262638A CN 106262638 A CN106262638 A CN 106262638A CN 201610624900 A CN201610624900 A CN 201610624900A CN 106262638 A CN106262638 A CN 106262638A
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- China
- Prior art keywords
- casing
- flavouring agent
- tank body
- plate
- vibrations
- Prior art date
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- 239000000796 flavoring agent Substances 0.000 title claims abstract description 41
- 235000013355 food flavoring agent Nutrition 0.000 title claims abstract description 41
- 210000000582 semen Anatomy 0.000 claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 9
- 244000268590 Euryale ferox Species 0.000 claims abstract description 6
- 235000006487 Euryale ferox Nutrition 0.000 claims abstract description 6
- 240000008669 Hedera helix Species 0.000 claims abstract description 6
- 240000000851 Vaccinium corymbosum Species 0.000 claims abstract description 6
- 235000003095 Vaccinium corymbosum Nutrition 0.000 claims abstract description 6
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims abstract description 6
- 235000021014 blueberries Nutrition 0.000 claims abstract description 6
- 229940079593 drug Drugs 0.000 claims abstract description 6
- 230000036039 immunity Effects 0.000 claims abstract description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 30
- 239000000741 silica gel Substances 0.000 claims description 28
- 229910002027 silica gel Inorganic materials 0.000 claims description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 23
- 239000000243 solution Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 239000007788 liquid Substances 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 16
- 239000012141 concentrate Substances 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 11
- 238000007790 scraping Methods 0.000 claims description 9
- 238000010790 dilution Methods 0.000 claims description 8
- 239000012895 dilution Substances 0.000 claims description 8
- 239000002184 metal Substances 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000012535 impurity Substances 0.000 claims description 7
- 239000012567 medical material Substances 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 5
- 229920005989 resin Polymers 0.000 claims description 5
- 230000033228 biological regulation Effects 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims description 4
- 238000012360 testing method Methods 0.000 claims description 4
- 230000008602 contraction Effects 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 235000013305 food Nutrition 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 2
- 229960001866 silicon dioxide Drugs 0.000 description 23
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 238000001035 drying Methods 0.000 description 7
- 239000002253 acid Substances 0.000 description 6
- 108010062580 Concanavalin A Proteins 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000003304 gavage Methods 0.000 description 4
- 210000004698 lymphocyte Anatomy 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000002304 perfume Substances 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 235000013599 spices Nutrition 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 2
- LAZPBGZRMVRFKY-HNCPQSOCSA-N Levamisole hydrochloride Chemical group Cl.C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 LAZPBGZRMVRFKY-HNCPQSOCSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000012531 culture fluid Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 2
- 229940114124 ferulic acid Drugs 0.000 description 2
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 2
- 235000001785 ferulic acid Nutrition 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000013558 reference substance Substances 0.000 description 2
- 230000003393 splenic effect Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229960003734 levamisole hydrochloride Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000004988 splenocyte Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/56—Mixers with shaking, oscillating, or vibrating mechanisms having a vibrating receptacle provided with stirring elements, e.g. independent stirring elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0261—Solvent extraction of solids comprising vibrating mechanisms, e.g. mechanical, acoustical
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B11/00—Machines or apparatus for drying solid materials or objects with movement which is non-progressive
- F26B11/18—Machines or apparatus for drying solid materials or objects with movement which is non-progressive on or in moving dishes, trays, pans, or other mainly-open receptacles
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
- F26B21/004—Nozzle assemblies; Air knives; Air distributors; Blow boxes
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
- F26B21/06—Controlling, e.g. regulating, parameters of gas supply
- F26B21/10—Temperature; Pressure
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/04—Agitating, stirring, or scraping devices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a kind of flavouring agent, extracted by following bulk drugs weight and be prepared from: blue berry 20g, Fructus Capsici 15g, Rhizoma Zingiberis Recens 10g, Fructus Chaenomelis 10g, Rhizoma Dioscoreae 6g, Semen Euryales 8g, Semen Lablab Album 20g, Radix Angelicae Sinensis 30g, Rhizoma Cyperi 10g, Bulbus Allii 15g, there is raising immunity.
Description
Technical field
The present invention relates to food extractive technique field, be specifically related to a kind of flavouring agent and flavouring agent.
Background technology
Flavouring agent extracting method in prior art, technique is coarse, backward, and impurity is many, and active constituent content is low, causes patient
Consumption is excessive, it has not been convenient to take, and has had a strong impact on this product and has applied in culinary art.
Summary of the invention
Goal of the invention: in order to solve the problems referred to above, it is an object of the invention to provide a kind of flavouring agent.
Technical scheme: it is an object of the invention to by following scheme realization:
A kind of flavouring agent, is extracted by following bulk drugs weight and is prepared from: blue berry 20g, Fructus Capsici 15g, Rhizoma Zingiberis Recens
10g, Fructus Chaenomelis 10g, Rhizoma Dioscoreae 6g, Semen Euryales 8g, Semen Lablab Album 20g, Radix Angelicae Sinensis 30g, Rhizoma Cyperi 10g, Bulbus Allii 15g, preparation method is: material of getting it filled
Adding the water of 10 times of weight of medical material, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of 8 times of weight of medical material, decoct 1 little
Time, medicinal liquid leaches, and merges twice decoction liquor, and being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the volume basis of alcohol content
Than reaching 75%, stirring, standing, filtration, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, makes
Refine with silica gel, in advance selected silica gel is loaded in resin column, after purified for described concentrated solution water being diluted, by instead simultaneously
Phase silicagel column, removes the impurity in liquid, collects whole effluent, continues to concentrate, is dried by concentrated solution, pelletizes, obtain tune
Taste substance granule.
Described flavouring agent, silica gel specific surface described in preparation method is 300～500m2/g, and pore volume is 0.70～0.90ml/
G, after described dilution, concentrated solution is by the separation of reverse phase silica gel post, eluting, to only going out water colorless.
Described flavouring agent, concentrates in said extracted method and uses device, including tank body, be arranged on the charging on described tank body
Mouth and the discharge nozzle being arranged on described tank base, be provided with discharge valve and filter, at described tank body on described discharge nozzle
Inside it is provided with shaft, described shaft is provided with stirring paddle, be provided with at the top of described tank body and be connected with described shaft
Stirring motor, the diapire in described tank body be provided with vibrations chamber, be provided with jolting plate at described vibrations intracavity, at described jolting plate
And being provided with electromagnetic shaker between described vibrations chamber, the sidewall in described tank body is provided with cavity, the end face at described jolting plate sets
Having scraper plate, be provided with telescopic cylinder between described scraper plate and described cavity, described scraper plate is real under the effect of described telescopic cylinder
The now scraping to jolting plate surface, is provided with the discharging opening being connected with described discharge nozzle at the center of described jolting plate.
Described flavouring agent, in said extracted method, jolting plate described in enrichment facility is provided with close with the junction in described vibrations chamber
Envelope bonding jumper, is provided with the shake control device being connected with described electromagnetic shaker, the end of scraper plate described in enrichment facility on described tank body
Portion is provided with metal scraping layer, and described metal scraping layer is pressed on described jolting plate, is provided with flexible with described on described tank body
The extension and contraction control button that cylinders connects, is provided with water tester in tank body described in enrichment facility, is provided with in described discharge nozzle
Cooler.
Described flavouring agent, is dried in said extracted method and uses device, including casing, be arranged on the material in described casing
Frame and the blast pipe and the discharge pipe that are arranged on described casing top, it is characterised in that: it is provided with in the sidewall of described casing and institute
State the air intake passage that blast pipe is connected, the sidewall of described casing is provided with the air holes being connected with described air intake passage, institute
State discharge pipe through described casing roof connection casing in casing outside, in the sidewall of described casing, be additionally provided with homoiothermic chamber
And sterilization chamber, it being provided with electrical heating block at described homoiothermic intracavity, described air intake passage is arranged through described regulation chamber and sterilization chamber,
It is provided with rotating drum in the diapire of described casing, in described rotating drum, is provided with electric rotating machine, the main shaft of described electric rotating machine and institute
Stating material frame to be connected, be provided with vibrations groove in described material frame, the end face at described material frame is provided with and holds plate, described
Hold and be provided with shaking device between plate and described vibrations groove.
Described flavouring agent, is dried in said extracted method and uses shaking device described in device to include driving motor, be arranged on
Eccentric on described driving electric machine main shaft, the wheel limit of described eccentric be pressed on described in hold the bottom center of plate, described
Holding and be provided with extension spring between the bottom of plate and the diapire of described vibrations groove, described extension spring symmetry centered by described eccentric sets
Put.
Described flavouring agent, is dried in said extracted method in using casing described in device and is provided with temperature sensor, described
The control of the driver being connected with described temperature sensor, described driver and described electrical heating block it is provided with in the sidewall of casing
End is connected, and is additionally provided with chamber door on described casing.
Described flavouring agent improves the application in immunity food in preparation suppression.
In prior art, the original extracting method of flavouring agent, technique is coarse, backward, and impurity is many, causes patient's consumption excessive,
Being inconvenient to take, ferulaic acid content prepared by the present invention increases, and content is high.Concentrator simple in construction in the present invention, operation
Convenient, it is provided with jolting plate and electromagnetic shaker, and is additionally provided with scraper plate and the telescopic cylinder being connected with described scraper plate, can effectively prevent
Tank base is lumpd, and is greatly improved the efficiency of heating surface to a certain extent, efficiently solves in conventional art Chinese medicinal concentration equipment and holds
Luming bottom easily occurring and affect the technical deficiency of the efficiency of heating surface, stability in use is good and the suitability strong, the effective ingredient of medicine
Stablize and be not destroyed.This drying equipment structure is simple, simple and quick, and it uses wall box to blow, and is additionally arranged
Electrical heating block, can be adjusted according to the temperature in case, thus ensure that the stability of baking temperature, and be provided with electric rotating
Machine and shaking device, can rotate and shake holding plate while heating, thus can prevent medicine local desiccation, thus
Dry efficiency can be improved to a certain extent, solve the technical deficiency that the drying device drying efficiency of conventional art is low.
Accompanying drawing explanation
In order to make present disclosure be more likely to be clearly understood, below according to specific embodiment and combine accompanying drawing, right
The present invention is described in further detail, wherein:
Fig. 1 is the structural representation of enrichment facility of the present invention.
Fig. 2 is the structural representation of drying device of the present invention.
Detailed description of the invention
Form by the following examples, is described in further detail the foregoing of the present invention again, but should be by this
Being interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to Examples below, all technology realized based on foregoing of the present invention are equal
Belong to the scope of the present invention.
Embodiment 1
Take blue berry 20g, Fructus Capsici 15g, Rhizoma Zingiberis Recens 10g, Fructus Chaenomelis 10g, Rhizoma Dioscoreae 6g, Semen Euryales 8g, Semen Lablab Album 20g, Radix Angelicae Sinensis 30g, perfume (or spice)
Attached 10g, Bulbus Allii 15g, add the water of 10 times of weight, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add 8 times of weight of medical material
Water, decocts 1 hour, and medicinal liquid leaches, and merges twice decoction liquor, and being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes alcohol content
Percent by volume reach 75%, stirring, stand, filter, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol,
Obtain concentrated solution, use silica gel to refine, obtain effluent, continue to concentrate, concentrated solution is dried, granulation, obtain flavouring agent granule.
Described flavouring agent, described silica gel process for purification is: load in resin column by selected silica gel in advance, simultaneously by described
After the dilution of concentrated solution purified water, by reverse phase silica gel post, remove the impurity in liquid, collect whole effluent.
Described flavouring agent, described silica gel specific surface is 300m2/ g, pore volume is 0.90ml/g, and after described dilution, concentrated solution leads to
Cross the separation of reverse phase silica gel post, eluting, to only going out water colorless.
See Fig. 1: described flavouring agent, concentrate for above-mentioned three times and use device, including tank body 1, be arranged on entering on described tank body 1
Expect mouth 2 and be arranged on the discharge nozzle 3 bottom described tank body 1, described discharge nozzle 3 is provided with discharge valve 4 and filter 5,
It is provided with shaft 6 in described tank body 1, described shaft 6 is provided with stirring paddle 7, be provided with described at the top of described tank body 1
The stirring motor 8 that shaft 6 is connected, the diapire in described tank body 1 is provided with vibrations chamber 9, is provided with shake in described vibrations chamber 9
Dynamic plate 10, is provided with electromagnetic shaker 11 between described jolting plate 10 and described vibrations chamber 9, jolting plate can be made to shake by electromagnetic shaker
Dynamic, thus can effectively prevent drug particles from concentrating on jolting plate, thus can prevent drug particles from luming on jolting plate, in institute
Stating the sidewall in tank body 1 and be provided with cavity 12, the end face at described jolting plate 10 is provided with scraper plate 13, at described scraper plate 13 with described
It is provided with telescopic cylinder 14 between cavity 12, telescopic cylinder can be controlled as required, make scraper plate scrape on the surface of jolting plate, from
And the drug particles that part concentrates at jolting plate surface scrapes, described scraper plate 13 realizes under the effect of described telescopic cylinder 14
Scraping to jolting plate 10 surface, is provided with the discharging opening 15 being connected with described discharge nozzle 3 at the center of described jolting plate 10.
It is provided with sealing metal bar 16 in the junction of described jolting plate 10 with described vibrations chamber 9, described tank body is provided with
The shake control device 17 being connected with described electromagnetic shaker.
Be provided with metal scraping layer 18 in the bottom of described scraper plate, described metal scraping layer is pressed on described jolting plate,
Described tank body is provided with the extension and contraction control button 19 being connected with described telescopic cylinder.
In described tank body, it is provided with water tester 21, in described discharge nozzle, is provided with cooler 20.
See Fig. 2: described flavouring agent, above-mentioned dry use device, including casing 1, be arranged on the material frame in described casing 1
2 and be arranged on blast pipe 3 and the discharge pipe 4 at described casing 1 top, it is provided with in the sidewall of described casing 1 and described blast pipe 3
The air intake passage 5 being connected, is provided with the air holes 6 being connected with described air intake passage 5, fresh air inlet on the sidewall of described casing 1
It is arranged on sidewall, it is ensured that the uniformity of ventilation, and the contact area with medicine can be greatly improved, described discharge pipe
4, through outside with casing 1 in the roof connection casing 1 of described casing 1, are additionally provided with homoiothermic chamber 7 He in the sidewall of described casing 1
Sterilization chamber 8, is provided with electrical heating block 9 in described homoiothermic chamber 7, and being provided with electrical heating block can enter the temperature of blast pipe as required
Row regulation, it is ensured that the stability of baking temperature, described air intake passage 5 is arranged, described through described regulation chamber 7 and sterilization chamber 8
It is provided with rotating drum 10 in the diapire of casing 1, in described rotating drum 10, is provided with electric rotating machine 11, the main shaft of described electric rotating machine 11
Being connected with described material frame 2, be provided with vibrations groove 12 in described material frame 2, the end face at described material frame 2 is provided with and holds
Plate 13, is provided with shaking device 14 described holding between plate 13 and described vibrations groove 12.
Described shaking device 14 includes driving motor 141, is arranged on the eccentric 142 on described driving motor 141 main shaft,
The wheel limit of described eccentric 142 holds the bottom center of plate 13 described in being pressed on, in the described bottom holding plate 13 and described shake
Being provided with extension spring 15 between the diapire of dynamic groove 12, described extension spring is symmetrical arranged centered by described eccentric, passes through in use
Compressing of eccentric makes to hold plate rising, when the recess of eccentric compresses and holds plate, holds plate and resets under the effect of extension spring,
Make the disengaging of thing material fall again after holding plate in dropping process and hold the vibrations realizing material on plate.
In described casing 1, it is provided with temperature sensor 16, is provided with in the sidewall of described casing and described temperature sensor
The driver 17 being connected, described driver is connected with the control end of described electrical heating block.Temperature passes dry device and driver is
Existing prior art on market, it has only to when using and connecting connect according to corresponding connection description.
Embodiment 2
Take blue berry 20g, Fructus Capsici 15g, Rhizoma Zingiberis Recens 10g, Fructus Chaenomelis 10g, Rhizoma Dioscoreae 6g, Semen Euryales 8g, Semen Lablab Album 20g, Radix Angelicae Sinensis 30g, perfume (or spice)
Attached 10g, Bulbus Allii 15g, add the water of 10 times of weight, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add 8 times of weight of medical material
Water, decocts 1 hour, and medicinal liquid leaches, and merges twice decoction liquor, and being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes alcohol content
Percent by volume reach 75%, stirring, stand, filter, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol,
Obtain concentrated solution, use silica gel to refine, obtain effluent, continue to concentrate, concentrated solution is dried, granulation, obtain flavouring agent granule.
Described flavouring agent, described silica gel process for purification is: load in resin column by selected silica gel in advance, simultaneously by described
After the dilution of concentrated solution purified water, by reverse phase silica gel post, remove the impurity in liquid, collect whole effluent.
Described a kind of flavouring agent, described silica gel specific surface is 500m2/g, and pore volume is 0.70ml/g, concentrates after described dilution
Liquid is separated by reverse phase silica gel post, eluting, to only going out water colorless.
Concentrate with drying equipment ibid.
Embodiment 3
Take blue berry 20g, Fructus Capsici 15g, Rhizoma Zingiberis Recens 10g, Fructus Chaenomelis 10g, Rhizoma Dioscoreae 6g, Semen Euryales 8g, Semen Lablab Album 20g, Radix Angelicae Sinensis 30g, perfume (or spice)
Attached 10g, Bulbus Allii 15g, add the water of 10 times of weight, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add 8 times of weight of medical material
Water, decocts 1 hour, and medicinal liquid leaches, and merges twice decoction liquor, and being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes alcohol content
Percent by volume reach 75%, stirring, stand, filter, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol,
Obtain concentrated solution, use silica gel to refine, obtain effluent, continue to concentrate, concentrated solution is dried, granulation, obtain flavouring agent granule.
Described flavouring agent, described silica gel process for purification is: load in resin column by selected silica gel in advance, simultaneously by described
After the dilution of concentrated solution purified water, by reverse phase silica gel post, remove the impurity in liquid, collect whole effluent.
Described flavouring agent, described silica gel specific surface is 400m2/g, and pore volume is 0.80ml/g, and after described dilution, concentrated solution leads to
Cross the separation of reverse phase silica gel post, eluting, to only going out water colorless.
Concentrate with drying equipment ibid.
Embodiment 4: ferulaic acid content determination experiment research data in flavouring agent of the present invention
1.1 Experimental agents: flavouring agent of the present invention: prepare by embodiment 1-3 method.Matched group is with reference to embodiment 1, uses
Common concentration is prepared with drying means, takes the flavouring agent granule that said method prepares.
1.2 instruments: high performance liquid chromatograph system includes high performance liquid chromatograph (Waters 515)；P200 high-pressure pump；
Waters 2487 UV-detector and GJ605 type high pressure six-way injection valve；Chromatographic column be BDS HYPERSIL-C18 (4.6mm ×
250mm, 5 μm)；Data acquisition and process use HS Data Processing in Chromatography Workstation V4.0+ (Hangzhou English spectrum science and technology)
1.3 condition determinations: measure according to high performance liquid chromatography (general rule 0512).Chromatographic condition and system suitability with
Octadecylsilane chemically bonded silica is filler；With methanol-water (60:40) for flowing phase；Detection wavelength is 250nm；Theoretical plate
Number is calculated by ferulic acid peak should be not less than 2000.Take ferulic acid reference substance appropriate, accurately weighed, add methanol and make every lml containing 5ug
Solution, to obtain final product.The preparation of need testing solution takes this product under content uniformity item, finely ground, takes about 0.5g, accurately weighed, puts
In 25ml measuring bottle, add methanol 20ml, supersound process (power 250W, frequency 40kHz) 30 minutes, let cool, add methanol to scale, shake
Even, filter, take subsequent filtrate, to obtain final product.Precision draws reference substance solution and need testing solution each 20ul injection chromatograph of liquid respectively,
Measure, to obtain final product.
1.4 experimental result
Ferulaic acid content measurement result in flavouring agent prepared by each embodiment
| Sample source | Ferulaic acid content (%) |
| Embodiment 1 | 2.5 |
| Embodiment 2 | 2.3 |
| Embodiment 3 | 1.9 |
| Matched group | 0.2 |
According to the result of the test of upper table, in flavouring agent prepared by embodiment of the present invention 1-3, ferulaic acid content is the highest
In matched group.
Embodiment 5: the present invention improves the pharmacodynamic study of immunity
Experiment purpose: by the embodiment of the present invention 1, gavage mice 30d, compares the present invention and normal group mice is induced by ConA
The difference of splenic lymphocyte proliferation, judge whether the present invention strengthens splenic lymphocyte proliferation.
Laboratory animal: Kunming mouse, male, body weight 18-22g, Shanghai Slac Experimental Animal Co., Ltd. provides, raw
Produce licence: SCXK (Shanghai) 2007-0005.
Experimental agents: prepare by the preparation method of above-described embodiment 1.
Experimental procedure: mice, is grouped by body weight stratified random, often group 12.As shown in the table, normal group gavage feeds water；
Levamisole hydrochloride group gavage levamisole hydrochloride；Embodiment 1 gavage 2g kg-1, the continuous gastric infusion 30d of each group.Aseptic take
Spleen, according to being conventionally produced individual cells suspension, adjusting cell concentration is 5 × 105Individual/mL.Splenocyte suspension is added in 24 holes
In plate, every hole 1mL, every animal sets two multiple holes, and (adding 50uL PRMI1640 culture fluid) is normally cultivated in a hole；One hole adds
50uL concanavalin A, Con A (ConA) liquid (final concentration of 4.76ug/mL).It is placed in 5%CO2, 37 DEG C of CO2Incubator is cultivated 48h.Experiment
4h before terminating, every hole sucks supernatant 700uL, adds the 700uL PRMI1640 culture fluid without hyclone, the most every hole
Add the MTT liquid of 50uL 5mg/mL.After cultivation terminates, every hole adds 1mL acid isopropyl alcohol, and careful piping and druming is uniformly to the knot of purple
Brilliant all dissolvings.Being dispensed into before detection in 96 well culture plates, 4 multiple holes are made in every hole, measure its optical density at 570nm wavelength
Value.
Experimental result:
The present invention on the impact of spleen lymphocyte proliferation (N=12)
Note: compared with normal groupP ＜ 0.01,P ＜ 0.05.
Conclusion: the rate of increase conversion values after the embodiment of the present invention 1 mouse spleen lymphocyte is induced by ConA is higher than normal
Group mice, illustrates have raising immunity.
Claims (8)
1. a flavouring agent, it is characterised in that extracted by following bulk drugs weight and be prepared from: blue berry 20g, Fructus Capsici
15g, Rhizoma Zingiberis Recens 10g, Fructus Chaenomelis 10g, Rhizoma Dioscoreae 6g, Semen Euryales 8g, Semen Lablab Album 20g, Radix Angelicae Sinensis 30g, Rhizoma Cyperi 10g, Bulbus Allii 15g, preparation method
For: material of getting it filled adds the water of 10 times of weight of medical material, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add 8 times of weight of medical material
Water, decocts 1 hour, and medicinal liquid leaches, and merges twice decoction liquor, and being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes alcohol content
Percent by volume reach 75%, stirring, stand, filter, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol,
Obtain concentrated solution, use silica gel to refine, in advance selected silica gel is loaded in resin column, simultaneously by dilute for purified for described concentrated solution water
After releasing, by reverse phase silica gel post, remove the impurity in liquid, collect whole effluent, continue to concentrate, concentrated solution is done
Dry, pelletize, obtain flavouring agent granule.
Flavouring agent the most according to claim 1, it is characterised in that silica gel specific surface described in preparation method is 300～500m2/
G, pore volume is 0.70～0.90ml/g, and after described dilution, concentrated solution is by the separation of reverse phase silica gel post, eluting, to only going out water colorless.
Flavouring agent the most according to claim 1, it is characterised in that concentrate in said extracted method and use device, including tank body,
The charging aperture being arranged on described tank body and the discharge nozzle being arranged on described tank base, be provided with outlet valve on described discharge nozzle
Door and filter, be provided with shaft in described tank body, be provided with stirring paddle on described shaft, set at the top of described tank body
Having the stirring motor being connected with described shaft, the diapire in described tank body is provided with vibrations chamber, sets at described vibrations intracavity
There is jolting plate, between described jolting plate and described vibrations chamber, be provided with electromagnetic shaker, the sidewall in described tank body is provided with cavity,
End face at described jolting plate is provided with scraper plate, is provided with telescopic cylinder between described scraper plate and described cavity, and described scraper plate is in institute
State and realize the scraping to jolting plate surface under the effect of telescopic cylinder, be provided with at the center of described jolting plate and described discharge nozzle phase
The discharging opening of connection.
Flavouring agent the most according to claim 3, it is characterised in that jolting plate described in enrichment facility and institute in said extracted method
The junction stating vibrations chamber is provided with sealing metal bar, is provided with the shake control being connected with described electromagnetic shaker on described tank body
Device, the bottom of scraper plate described in enrichment facility is provided with metal scraping layer, and described metal scraping layer is pressed on described jolting plate, in institute
State tank body and be provided with the extension and contraction control button being connected with described telescopic cylinder, in tank body described in enrichment facility, be provided with moisture content test
Instrument, is provided with cooler in described discharge nozzle.
Flavouring agent the most according to claim 1, it is characterised in that be dried in said extracted method and use device, including casing,
The material frame being arranged in described casing and the blast pipe and the discharge pipe that are arranged on described casing top, it is characterised in that: in institute
Be provided with the air intake passage being connected with described blast pipe in stating the sidewall of casing, the sidewall of described casing is provided with described enter
The air holes that wind passage is connected, described discharge pipe through described casing roof connection casing in casing outside, at described case
Being additionally provided with homoiothermic chamber and sterilization chamber in the sidewall of body, be provided with electrical heating block at described homoiothermic intracavity, described air intake passage passes institute
State regulation chamber and sterilization chamber arranged, in the diapire of described casing, be provided with rotating drum, in described rotating drum, be provided with electric rotating machine,
The main shaft of described electric rotating machine is connected with described material frame, is provided with vibrations groove in described material frame, at described material frame
End face be provided with and hold plate, be provided with shaking device described holding between plate and described vibrations groove.
Flavouring agent the most according to claim 5, it is characterised in that be dried in said extracted method and use vibrations dress described in device
Putting and include driving motor, be arranged on the eccentric on described driving electric machine main shaft, the wheel limit of described eccentric is pressed on described Sheng
Put the bottom center of plate, between the diapire of the described bottom holding plate and described vibrations groove, be provided with extension spring, described extension spring with
It is symmetrical arranged centered by described eccentric.
Flavouring agent the most according to claim 5, it is characterised in that be dried in said extracted method in using casing described in device
It is provided with temperature sensor, in the sidewall of described casing, is provided with the driver being connected with described temperature sensor, described driving
Device is connected with the control end of described electrical heating block, is additionally provided with chamber door on described casing.
Flavouring agent application in preparation improves immunity food the most according to claim 1.
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| CN201610624900.2A CN106262638A (en) | 2016-07-30 | 2016-07-30 | A kind of flavouring agent |
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| CN201610624900.2A CN106262638A (en) | 2016-07-30 | 2016-07-30 | A kind of flavouring agent |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106117278A (en) * | 2016-06-14 | 2016-11-16 | 南京华宽信息咨询中心 | The extracting method of a kind of rhodioside and rhodioside extract |
| CN109349591A (en) * | 2018-10-25 | 2019-02-19 | 王付国 | The instant flavouring of drysaltery complex solid |
| CN109579478A (en) * | 2018-12-19 | 2019-04-05 | 宣城市鹤鸣茶叶机械制造有限公司 | A kind of novel tea stirs drying device |
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| CN1100905A (en) * | 1993-10-04 | 1995-04-05 | 高福星 | Flavorous nutrient seasoning and health-keeping medicine |
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| CN103652761A (en) * | 2013-11-21 | 2014-03-26 | 定远县南德调味品加工厂 | Assorted seasoning and preparation method thereof |
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| CN106117278A (en) * | 2016-06-14 | 2016-11-16 | 南京华宽信息咨询中心 | The extracting method of a kind of rhodioside and rhodioside extract |
| CN109349591A (en) * | 2018-10-25 | 2019-02-19 | 王付国 | The instant flavouring of drysaltery complex solid |
| CN109579478A (en) * | 2018-12-19 | 2019-04-05 | 宣城市鹤鸣茶叶机械制造有限公司 | A kind of novel tea stirs drying device |
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Application publication date: 20170104 |