CN1062475C - Styptic for gynaecology - Google Patents
Styptic for gynaecology Download PDFInfo
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- CN1062475C CN1062475C CN97100443A CN97100443A CN1062475C CN 1062475 C CN1062475 C CN 1062475C CN 97100443 A CN97100443 A CN 97100443A CN 97100443 A CN97100443 A CN 97100443A CN 1062475 C CN1062475 C CN 1062475C
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Abstract
The present invention relates to a styptic medicine for gynaecology, specifically to a Chinese patent medicine prepared from Chinese herbal medicines as raw materials for treating gynecological hemorrhage symptoms caused by various reasons with the functions of arresting hemorrhage and alleviating pain. The medicine is prepared from humifuse euphorbia herb, milkvetch root, donkey-hide gelatin, Chinese date and brown sugar.
Description
The present invention relates to a kind of styptic for gynaecology, specifically be a kind of be the Chinese patent medicine that feedstock production forms with the Chinese herbal medicine, be used for the treatment of the gynecological bleeding disease that a variety of causes causes, have the effect of hemostasis and pain-relieving, belong to the field of Chinese medicines.
China is populous, and family planning is the fundamental state policy of a n-th-trem relation n national economy.Therefore, research and development contraceptive, contragestive agent is the key subjects of China's survival and development of concerning.Owing to various reason, the gravid woman wishes to stop early pregnancy, takes latent (mifepristone) compatibility prostaglandin of breath, carries out drug induced abortion, is the clinical the most frequently used method of present family planning.Latent (mifepristone Mifepristone) source of breath is because the antiearly pregnancy synthetic drug of France's development.As a kind of progesterone antagonist, the affinity with progesterone receptor is higher five times than Progesterone in vivo for it, can substitute the combination of natural progesterone isoacceptor, causes decidua and villus degeneration, hemorrhage and endogenous prostaglandin release, brings out uterine contraction, stops fetal development.Clinical same prostaglandin E
1The class drug combination utilizes the latter to shrink the uterus, and the effect of softening cervix impels downright bad blastular and fluffy balls to discharge outside the uterine cavity, reaches the purpose of miscarriage.This medicine is promoted in China, and only just there are nearly 3,000,000 person-times of employings in 94 years whole nations, and the miscarriage success rate is more than 95%.This method is simple and easy to do, and drug effect is sure, than dilatation and curettage, induced labor operation incomparable superiority is arranged.But take this medicine post-abortion, most case vaginal hemorrhage times are long, amount of bleeding is many.According to clinical report the massive hemorrhage that happens suddenly is arranged after a few days, tens of days, even life-threatening phenomenon takes place, restriction to a certain degree the latent application of breath.In addition, United Nations Children's Fund not long ago announced on average have every day 1,600 women dead in pregnant process in the world in the USA New York, be to have every year nearly 600,000 women to die to bear children constantly, its cause of the death mainly is hyperhematosis (seeing healthy newspaper on October 10th, 96).This shows that the research of Chinese medicine styptic for gynaecology, development and application obviously have more wide prospect.
The present invention seeks at the key issue that goes out hyperhematosis due at present clinically behind women's drug induced abortion, the medicine that determined curative effect, dosage form are suitable, played the hemostasis and pain-relieving effect in 3～5 days post-abortions is provided.
Medicine of the present invention be fully excavate and inherit motherland's medicine and pharmacology treatment postpartum hemorrhage, coating not inferior aspect on the basis of invaluable experience, develop in conjunction with modern advanced person's preparation process.
Because specific epoch and medical technique level, motherland's medical literature bleeding problems behind the drug induced abortion of surely not touching upon, but to the abortion of similar " artificial abortion ", induced abortion etc. cause hemorrhage, still have comparatively comprehensively in the tradition department of obstetrics and gynecology and discuss, accumulated rich experience in the cause of disease, pathogenesis, diagnosis, the rule of treatment, medication each side.As " Jing Yue's complete work married woman rule " cloud: " card of abortion has weight, distance is arranged, natural endowment is arranged, occurrences in human life is arranged.Because of natural endowment person, mostly be weak; Because of occurrences in human life person, mostly be damage ".Xue Qiuzhai has also done lively description to abortion, miscarriage to the damage of human body in " women section brief points ", " abortion overweights big product.Lid is big to be produced as the ripe autospasy of chestnut, and abortion is adopted as giving birth to, and broken its cot, disconnected its root base of a fruit wouldn't overweight big product ".The impairment of chong and ren channels is lost in transferring admittedly, then bleeds too much; If surplus blood is not to the greatest extent, under the decidua not, then in the blood stasis palace.Neat Zhong Fu of Song dynasty is at " women section hundred is asked " medium cloud: " menses are decreased in induced abortion, go out incessantly, have two: Yin Re and scattering first, the deficiency of vital energy and not holding back first.Rushing down the many persons of blood must be unhappy and dead; Or because of air-cooled abortionist, blood is cold fights mutually, and the contrary last then blood agglomeration of the deficiency of vital energy does not go out, rob make a psychological attack then unhappy and dead ".Pointing out to go out hyperhematosis after the abortion, is to be formed by the deficiency of vital energy or blood stasis.In Qing Dynasty's "Fu Qingzhu works on obstetric" detailed argumentation has been done in the treatment of the medication after the abortion, " abortion is with abortion is not different.Not abortion and tire uneasiness person should turn round and look at its tire and can not gently remove its blood; Own abortion and blood does not collapse greatly the person, its stasis of blood of should loosing and not severely injured its gas ".The exception that motherland's traditional medicine will be miscarried, normal pregnancy is regarded in abortion as, how by due to natural endowment, the occurrences in human life, quivering to compose is endogenous cause of ill, occurrences in human life are exopathogenic factor.Though drug induced abortion is not quite similar with occurrences in human life, also belong to exopathogenic factor.The inventor with reference to Zhang Zhongjing in " Medical Treasures of the Golden Chamber married woman gestation abnormal pulse card is also controlled ", dash the practice of appointing " continuous hematochezia the is all without cease " disease due to the deficiency puerperal with the Ass-hide Glue and Argyi Leaf Decoction treatment of transferring that Gu Chong appoints, warming the meridian is taken the photograph blood, recent two decades comes based on Herba Euphorbiae Humifusae, medicines such as the compatibility Radix Astragali, Colla Corii Asini go out gynecologic blood diseases such as hyperhematosis after having treated many cases metrorrhagia or artificial abortion.Therefore, we inherit the method for ancient Chinese medicine treatment gynecologic blood diseases, draw the experience of contemporary Amino-Cerv, adopt again accent among the people mend the married woman just, the medication custom after the abortion, amass development person's practice summary of two more than ten years again, invented the medicine of present patent application through strict determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, the design of prescription compatibility.
The prescription legislation principles of medicine of the present invention is hemostasia and dissipation blood stasis, benefiting QI and nourishing blood, tonifying Chong and Ren channels.Be monarch drug with the Herba Euphorbiae Humifusae in the side, reuse that to get its nature and flavor gentle, temperature is cool suitable, adapts to the characteristics of Amino-Cerv, and minister is enriched blood with QI invigorating such as the Radix Astragali, Colla Corii Asini, also have flavour of a drug of anastalsis, its hemostasia and dissipation blood stasis, benefiting QI and nourishing blood etc. act on then more comprehensively, two medicines, one gas, one blood, principal drug assistance Herba Euphorbiae Humifusae hemostasia and dissipation blood stasis, QI invigorating astringency inducing altogether, but vigorate qi and replenish the blood, tonifying Chong and Ren channels again is postabortal deficient to control.In addition Fructus Jujubae, brown sugar tonifying Chong and Ren channels, assistant makes all medicines of the monarch and his subjects, and drug effect is strengthened.Herba Euphorbiae Humifusae is an euphorbia plant, contains a large amount of tannins and flavone compound, and outer time spent tannin has astriction, shows certain anastalsis; Yet DeGrain when for oral administration.Through removing tannin, extract the preparation (injection, oral liquid) that flavone compound makes, its anastalsis is more obvious.
Therefore, medicine of the present invention is composed as follows:
Herba Euphorbiae Humifusae 200-500 weight portion
Radix Astragali 140-280 weight portion
Colla Corii Asini 50-100 weight portion
Fructus Jujubae 100-200 weight portion
The preferred weight proportioning that medicine of the present invention is formed is:
Herba Euphorbiae Humifusae 300-400 weight portion
Radix Astragali 200-250 weight portion
Colla Corii Asini 80-90 weight portion
Fructus Jujubae 100-200 weight portion
Above-mentioned pharmaceutical composition is the drug effect core of medicine of the present invention, as long as contain the above-mentioned pharmaceutical composition of the present invention, can reach therapeutic purposes of the present invention.
Medicine of the present invention can also contain the brown sugar of medicine-food two-purpose except that containing above-mentioned pharmaceutical composition, the brown sugar sweet in the mouth is warm in nature, has the effect of promoting the flow of QI-blood by warming the meridian, nourishing blood to promote the production of body fluid, and all medicines are gone into blood system in the side of drawing, and as messenger drug, makes the prescription of medicine of the present invention more reasonable.
Therefore, the preferred group of medicine of the present invention becomes:
Herba Euphorbiae Humifusae 200-500 weight portion
Radix Astragali 140-280 weight portion
Colla Corii Asini 50-100 weight portion
Fructus Jujubae 100-200 weight portion
Brown sugar 50-100 weight portion
The preferred weight proportioning that the invention described above medicine is formed is:
Herba Euphorbiae Humifusae 300-400 weight portion
Radix Astragali 200-250 weight portion
Colla Corii Asini 80-90 weight portion
Fructus Jujubae 100-200 weight portion
Brown sugar 80-90 weight portion
The best of medicine of the present invention is formed and proportioning is:
Herba Euphorbiae Humifusae 500 weight portions
The Radix Astragali 250 weight portions
Colla Corii Asini 84 weight portions
Fructus Jujubae 167 weight portions
Brown sugar 84 weight portions
Pharmaceutical composition of the present invention can also add drug excipient commonly used in the pharmaceutics field according to the needs of dosage form, for example, solvent, filler, flavoring agent, disintegrating agent, binding agent, lubricant, wetting agent, pigment, solubilizing agent, diluent, thickening agent etc.
According to the preparation technique of routine, medicine of the present invention can be prepared into any pharmaceutical preparation that is suitable for clinical use, for example, and pill, tablet, powder, injection, oral liquid, capsule, suspensoid, unguentum, granule, injectable powder, masticatory etc.
The preferred dosage form of pharmaceutical composition of the present invention is a syrup.
The preparation method of medical syrup agent of the present invention is as follows:
1. take by weighing recipe quantity Herba Euphorbiae Humifusae decoction pieces and put in the extraction pot, add the deionized water of 10 times of amounts, soak 1 hour post-heating and decoct little boiling 15 hours.Leaching medicinal liquid, medicinal residues add 8 times of amounts of water again and decocted 1 hour, and the filtering medicinal residues merge twice medicinal liquid.Get supernatant and pack in the concentration tank, heating concentrates to such an extent that emit during spice equivalent volumes (g/ml) and cool, and stirs to add ethanol down and make and contain alcohol and measure and reach 70%, 0～5 ℃ of cold preservations and left standstill 24 hours.Filter, pure liquid is clarified in leaching, is 7.5 with 40% sodium hydroxide adjust pH, and cold preservation was left standstill 48 hours once more.Filter, leaching is clarified pure liquid and is put in the extraction pot, and decompression recycling ethanol is concentrated into spice amount equal-volume (g/ml) to the greatest extent after emitting, and 0～5 ℃ left standstill cold preservation 48 hours, filtered standby.
By recipe quantity take by weighing the Radix Astragali respectively, the Fructus Jujubae decoction pieces is put in the extraction pot, the deionized water that adds 8 times of amounts soaks and littlely after 2 hours to boil the leaching medicinal liquid 2 hours; Medicinal residues add 6 times of amounts of water again, little boiling 1 hour, and the leaching medicinal liquid discards medicinal residues.Merge medicinal liquid twice, get supernatant and squeeze into concentration tank, heating is concentrated into spice amount equal-volume (g/ml), emits and cools, and adds ethanol and makes and contain the alcohol amount and reach 60%, 0～5 ℃ of cold preservations and left standstill 24 hours.Leaching is clarified pure liquid and is put in the extraction pot, and decompression recycling ethanol is emitted the equal-volume (g/ml) that is concentrated into inventory to the greatest extent, and 0～5 ℃ left standstill cold preservation 48 hours, filtered standby.
3. the Colla Corii Asini of title recipe quantity is smashed and is sieved, and adds an amount of stirring of hot water and makes molten entirely.Siphon goes out lower floor's medicinal liquid after being chilled to room temperature, and the oil slick layer is put in addition.Heating once more, repetitive operation does not have oil slick until the surface, is added in the Herba Euphorbiae Humifusae extracting solution of preheating, and it is shared that the oil slick lamination that skims and other criticize Colla Corii Asini.
4. get the Radix Astragali, the preheating of Fructus Jujubae extracting solution, stir and be blended into brown sugar, continue heating and make dissolving fully, filter.The same Herba Euphorbiae Humifusae of filtrate, Colla Corii Asini medicinal liquid merge, add again total amount 0.15% by potassium sorbate, stir and make dissolving fully.Put room temperature and cool, adjust volume to aequum, packing was sterilized 30 minutes, and was got final product for 115 ℃.
The function of medicine of the present invention cures mainly and is:
Hemostasia and dissipation blood stasis, benefiting QI and nourishing blood, tonifying Chong and Ren channels.Be used for not purgation disease of vaginal bleeding after drug abortion, demoulding, also can be used for treating gynecological's blood disorders such as metrorrhagia, menorrhagia.Disease sees that vaginal bleeding volume is many, and color is red piece, sagging distention in the smaller abdomen pain, or see breathe hard, Mental fatigue, weak, lusterless complexion, light red tongue or held ecchymosis under the arm, deep,thready and forceless pulse etc.
Following zoopery has confirmed the drug action of medicine of the present invention (commodity bright and beautiful brown sugar slurry by name).
Experimental example 1 bright and beautiful brown sugar slurry is to the influence of clotting time of mice
Test objective:
Observe of the influence of bright and beautiful brown sugar slurry with the docking method to clotting time of mice.
Test material:
1. medicine: bright and beautiful brown sugar slurry (the 1.25g crude drug/ml), lot number: 950824, provide by China Medical Science Foundation tcm development center, reagent was condensed into 2: 1, press desired concn with distilled water during administration and diluted.Radix Notoginseng powder is produced by decoction pieces factory of Beijing Tongrentang.2. animal: Kunming kind white mice, body weight 20 ± 2.0g, the male and female dual-purpose is provided by China Academy of TCM's Experimental Animal Center.The quality certification: moving word 01-3064 number of doctor.
Test method:
Get 50 of white mice, be divided into five groups at random, male and female half and half.(1) bright and beautiful brown sugar slurry 12.5g crude drug/kg group (quite clinical dosage is 10 times); (2) bright and beautiful brown sugar slurry 25.0g crude drug/kg group (quite clinical dosage is 20 times); (3) bright and beautiful brown sugar slurry 50.0g crude drug/kg group (quite clinical dosage is 40 times); (4) Radix Notoginseng powder 1.0g/kg group (Radix Notoginseng divide be suspended among 1% the CMC); (5) blank group gives the distilled water with volume.The continuous gastric infusion of each treated animal three days after 30 seconds, adopts the docking method to measure clotting time respectively in the last administration.Promptly cut off moment at 1cm place, mouse tail tip, every 30 seconds with pin will the place of cutting off drop of blood choose once, cut off the hemorrhage beginning in back certainly, till the blood clotting silk occurring, the record clotting time calculates clotting time and shortens percentage rate.Result of the test: see attached list.
Brocade brown sugar slurry affects to clotting time of mice that the contracting of medicine clotting clotting time is hemorrhage to go out the drop of blood number and subtract group dosage number, (s) lack percentage and drip the few percentage g/kg of number, (only) X ± SD % X % blank group distilled water 10ml 10 413.1 ± 135.3 3.4 bright and beautiful brown sugar are starched 12.5 10 390.5 ± 103.7 △, 25.0 3.5 2.9 bright and beautiful brown sugar and are starched 25.0 10 287.7 ± 95.2*30.3 3.8 11.0 bright and beautiful brown sugar starch 50.0 10 257.1 ± 89.4
*35.1 1.7 50.0 Radix Notoginseng powder 1.0 10 248.6 ± 62.4
* *39.8 1.7 50.0 △ P＞0.05
*P＜0.05
*P＜0.02
* *P＜0.001
Experimental example 2 brown sugar slurry is to the analgesic activity of mice
Purpose: observe the analgesic activity of bright and beautiful brown sugar slurry to mice (writhing method).
Material:
One, medicine: bright and beautiful brown sugar slurry (1.25g crude drug/ml) provide by China Medical Science Foundation tcm development center.Aspirin (enteric coatel tablets, 40mg/ sheet), Bikai Pharmaceutics Co., Hainan prov.'s product, lot number: 95080,
Two, animal: Kunming mouse, body weight 20 ± 2.0g, male and female half and half.The moving word of quality certification doctor 01-3057 number is provided by animal housing of Inst. of Epidemiology and Microbiology, Chinese Academy of Preventive Medicine (.
Method:
Get 40 of mices, be divided into four groups at random, 10 every group, male and female half and half.One group of blank, two groups of aspirin 0.2g/kg groups, three groups of brocade brown sugar slurry 50g crude drug/kg groups (quite the clinical application amount is 40 times), three groups of brocade brown sugar slurry 25g crude drug/kg groups (quite the clinical application amount is 20 times).Brocade brown sugar was starched continuous gastric infusion three days, and the last administration is after 30 minutes, and each only organizes equal lumbar injection acetic acid 0.2ml/, observed respectively to organize mice in 15 minutes and this number of writhing response (abdominal part indent, stretching, extension hind leg, buttocks are raised) occurs.The result carries out statistical disposition, and calculates the analgesia percentage rate.
Matched group writhing response number of times-administration group writhing response number of times
Analgesia percentage rate (%)=-----------------* 100%
Administration group writhing response number of times
The result:
Brocade brown sugar slurry 50g crude drug/kg group all can obviously reduce the mouse writhing reaction times with the aspirin group, with matched group the difference (P＜0.01, P＜0.001) of highly significant is arranged more all,
Show that bright and beautiful brown sugar slurry successive administration has analgesic activity (seeing Table).
Brocade brown sugar slurry is to the analgesic activity of mouse, (writhing method) group dosage number of animals writhing response number of times P value analgesia percentage is other, (g/kg), (n), (X ± SD), (%) blank 10 30.3 ± 10.26 aspirin 0.2 10 7.3 ± 6.69＜0.001 75.9 bright and beautiful brown sugar is starched 50.0 10 19.3 ± 6.28＜0.01 36.3 bright and beautiful brown sugar and is starched 25.0 10 23.6 ± 6.32＞0.05 22.1 conclusions: adopt the docking method to test bright and beautiful brown sugar slurry to the clotting time of mouse. The result shows, compare with matched group, brocade brown sugar slurry 12.5g crude drug/kg group, 25.0g crude drug/kg group, 50.0g crude drug/kg group clotting time shorten 25.0%, 30.3% (P＜0.05), 35.1% (P＜0.02) respectively, and Radix Notoginseng powder group clotting time shortens 47.6% (P＜0.001) .Results suggest, bright and beautiful brown sugar slurry haemostatic effect is remarkable, is a Hemostatic of traditional herb medicine compound recipe preferably.Adopt writhing method to observe the analgesic activity of bright and beautiful brown sugar slurry to mice.The continuous gastric infusion of brocade brown sugar slurry 50g biology/kg (quite the clinical application amount is 40 times) three days, analgesic effect is (P＜0.01) very obviously.Results suggest brocade brown sugar slurry successive administration has analgesic activity.
Embodiment 1
Herba Euphorbiae Humifusae 500g
Radix Astragali 250g
Colla Corii Asini 84g
Fructus Jujubae 167g
Brown sugar 84g
Take by weighing recipe quantity Herba Euphorbiae Humifusae decoction pieces and put in the extraction pot, add the deionized water of 10 times of amounts, soak 1 hour post-heating and decoct little boiling 1.5 hours.Leaching medicinal liquid, medicinal residues add 8 times of amounts of water again and decocted 1 hour, and the filtering medicinal residues merge twice medicinal liquid.Get supernatant and pack in the concentration tank, heating concentrates to such an extent that emit during spice equivalent volumes (g/ml) and cool, and stirs to add ethanol down and make and contain alcohol and measure and reach 70%, 0～5 ℃ of cold preservation was left standstill 24 hours, filtered, and pure liquid is clarified in leaching, with 40% sodium hydroxide adjust pH is 7.5, and cold preservation was left standstill 48 hours once more.Filter, leaching is clarified pure liquid and is put in the extraction pot, and decompression recycling ethanol is concentrated into spice amount equal-volume (g/ml) to the greatest extent after emitting, and 0～5 ℃ left standstill cold preservation 48 hours, filtered standby.
By recipe quantity take by weighing the Radix Astragali respectively, the Fructus Jujubae decoction pieces is put in the extraction pot, the deionized water that adds 8 times of amounts soaks and littlely after 2 hours to boil the leaching medicinal liquid 2 hours; Medicinal residues add 6 times of amounts of water again, little boiling 1 hour, and the leaching medicinal liquid discards medicinal residues.Merge medicinal liquid twice, get supernatant and squeeze into concentration tank, heating is concentrated into spice amount equal-volume (g/ml), emits and cools, and adds ethanol and makes and contain the alcohol amount and reach 60%, 0～5 ℃ of cold preservations and left standstill 24 hours.Leaching is clarified pure liquid and is put in the extraction pot, and decompression recycling ethanol is emitted the equal-volume (g/ml) that is concentrated into inventory to the greatest extent, and 0～5 ℃ left standstill cold preservation 48 hours, filtered standby.
The Colla Corii Asini of title recipe quantity is smashed and is sieved, and adds an amount of stirring of hot water and makes molten entirely.Siphon goes out lower floor's medicinal liquid after being chilled to room temperature, and the oil slick layer is put in addition.Heating once more, repetitive operation does not have oil slick until the surface, is added in the Herba Euphorbiae Humifusae extracting solution of preheating.It is shared that the oil slick lamination that skims and other criticize Colla Corii Asini.
Get the Radix Astragali, the preheating of Fructus Jujubae extracting solution, stir and be blended into brown sugar, continue heating and make dissolving fully, filter, the same Herba Euphorbiae Humifusae of filtrate, Colla Corii Asini medicinal liquid merge, and add the potassium sorbate of total amount 0.15% again, stir to make dissolving fully.Put room temperature and cool, adjust volume to 1000 milliliter, packing, 115 ℃ of sterilizations 30 minutes get final product.
Embodiment 2
Herba Euphorbiae Humifusae 500g
Radix Astragali 140g
Colla Corii Asini 50g
Fructus Jujubae 100g
With above-mentioned medical material pulverize separately, sieve, make fine powder, add refined honey, mix homogeneously is made honeyed pill.
Claims (7)
1, a kind of styptic for gynaecology is characterized in that this medicine is to be made by the raw material of following consumption:
Herba Euphorbiae Humifusae 200-500 weight portion
Radix Astragali 140-280 weight portion
Colla Corii Asini 50-100 weight portion
Fructus Jujubae 100-200 weight portion.
2, medicine according to claim 1 is characterized in that the consumption of described raw material is:
Herba Euphorbiae Humifusae 300-400 weight portion
Radix Astragali 200-250 weight portion
Colla Corii Asini 80-90 weight portion
Fructus Jujubae 100-200 weight portion.
3, medicine according to claim 2 is characterized in that the consumption of described raw material is:
Herba Euphorbiae Humifusae 500 weight portions
The Radix Astragali 250 weight portions
Colla Corii Asini 84 weight portions
Fructus Jujubae 167 weight portions.
4,, it is characterized in that also adding in this medicine material brown sugar 50-100 weight portion according to claim 1 or 2 or 3 described medicines.
5, medicine according to claim 4, the content that it is characterized in that brown sugar are the 80-90 weight portions.
6, medicine according to claim 5, the content that it is characterized in that brown sugar are 84 weight portions.
7, a kind of styptic for gynaecology is characterized in that it is the syrup made from following raw material and method for making:
Herba Euphorbiae Humifusae 500g
Radix Astragali 250g
Colla Corii Asini 84g
Fructus Jujubae 167g
Brown sugar 84g
Taking by weighing recipe quantity Herba Euphorbiae Humifusae decoction pieces puts in the extraction pot, the deionized water that adds 10 times of amounts, soaking 1 hour post-heating decocts, little boiling 1.5 hours, leaching medicinal liquid, medicinal residues add 8 times of amounts of water again and decocted 1 hour, the filtering medicinal residues, twice medicinal liquid merged, get supernatant and pack in the concentration tank, heating concentrates to such an extent that emit during spice equivalent volumes (g/ml) and cool, stir and to add ethanol down and make and contain alcohol and measure and reach 70%, 0-5 ℃ of cold preservation was left standstill 24 hours, filtered, and pure liquid is clarified in leaching, with 40% sodium hydroxide adjust pH is 7.5, cold preservation was left standstill 48 hours once more, filtered, and leaching is clarified pure liquid and put in the extraction pot, decompression recycling ethanol is to most, be concentrated into spice amount equal-volume (g/ml) after emitting, 0-5 ℃ left standstill cold preservation 48 hours, filtered standby;
By recipe quantity take by weighing the Radix Astragali respectively, the Fructus Jujubae decoction pieces is put in the extraction pot, the deionized water that adds 8 times of amounts soaks and littlely after 2 hours to boil the leaching medicinal liquid 2 hours; Medicinal residues add 6 times of amounts of water again, littlely boil the leaching medicinal liquid 1 hour, discard medicinal residues, merge medicinal liquid twice, get supernatant and squeeze into concentration tank, heating is concentrated into spice amount equal-volume (g/ml), emits and cools, and adds ethanol and makes and contain the alcohol amount and reach 60%, 0-5 ℃ of cold preservation was left standstill 24 hours, leaching is clarified pure liquid and is put in the extraction pot, and decompression recycling ethanol is emitted the equal-volume (g/ml) that is concentrated into inventory to the greatest extent, 0-5 ℃ left standstill cold preservation 48 hours, filtered standby;
Claim the Colla Corii Asini of recipe quantity to smash and sieve, add hot water an amount of stir make molten entirely, be chilled to room temperature after siphon go out lower floor's medicinal liquid, the oil slick layer is put in addition, heating once more, repetitive operation, do not have oil slick until the surface, be added in the Herba Euphorbiae Humifusae extracting solution of preheating, it is shared that the oil slick lamination that skims and other criticize Colla Corii Asini;
Get the Radix Astragali, the preheating of Fructus Jujubae extracting solution, stirring is blended into brown sugar, continues heating and makes dissolving fully, filters, the same Herba Euphorbiae Humifusae of filtrate, Colla Corii Asini medicinal liquid merge, the potassium sorbate that adds total amount 0.15% again stirs to make and dissolves fully, puts room temperature and cools, adjust volume to 1000 milliliter, packing was sterilized 30 minutes, and was got final product for 115 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97100443A CN1062475C (en) | 1997-02-03 | 1997-02-03 | Styptic for gynaecology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97100443A CN1062475C (en) | 1997-02-03 | 1997-02-03 | Styptic for gynaecology |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1161850A CN1161850A (en) | 1997-10-15 |
| CN1062475C true CN1062475C (en) | 2001-02-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97100443A Expired - Fee Related CN1062475C (en) | 1997-02-03 | 1997-02-03 | Styptic for gynaecology |
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| CN (1) | CN1062475C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1116073C (en) * | 1999-10-14 | 2003-07-30 | 刘春萍 | Medicine for treating gynopathy and its preparing process |
| CN100409763C (en) * | 2003-04-14 | 2008-08-13 | 胡延忠 | Donkey-hide gelatin brown sugar |
-
1997
- 1997-02-03 CN CN97100443A patent/CN1062475C/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 河北中医1989第5期 1989.1.1 高慧明益气养阴固冲汤治疗妇科出血症87例 * |
| 河北中医1989第5期 1989.1.1 高慧明益气养阴固冲汤治疗妇科出血症87例;陕西中医1987第4期 1987.1.1 吕兰薰止血中药的研究动态 * |
| 陕西中医1987第4期 1987.1.1 吕兰薰止血中药的研究动态 * |
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| CN1161850A (en) | 1997-10-15 |
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