CN106237371A - Two-layer compound sthptic sponge, the mould making two-layer compound sthptic sponge and method - Google Patents
Two-layer compound sthptic sponge, the mould making two-layer compound sthptic sponge and method Download PDFInfo
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- CN106237371A CN106237371A CN201610836368.0A CN201610836368A CN106237371A CN 106237371 A CN106237371 A CN 106237371A CN 201610836368 A CN201610836368 A CN 201610836368A CN 106237371 A CN106237371 A CN 106237371A
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- sthptic sponge
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- layer compound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/102—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention provides a kind of two-layer compound sthptic sponge, including liquid-adsorption layer and adhesion layer, described adhesion layer is provided with through hole；A kind of mould making two-layer compound sthptic sponge, including die body, is provided with boss in described die body, described boss is positioned at die body center, and the shape of described boss is adaptive with described through hole, and described boss is formed around corresponding groove；A kind of manufacture method making two-layer compound sthptic sponge: uncrosslinked collagen solution or chitosan are cast in the groove of mould and freeze；To continue to be cast in mould through the collagen solution of chemical crosslinking；And freeze, the most freeze-dried obtain double-deck two-layer compound sthptic sponge.Product of the present invention had not only had excellent adhesion property and simultaneously but also had possessed good absorption sepage performance；And its manufacture method convenient and efficient, there is wide market prospect.
Description
Technical field
The invention belongs to medical dressing field, particularly to two-layer compound sthptic sponge, make two-layer compound sthptic sponge
Mould and method.
Background technology
Sthptic sponge, as a kind of common medical disposable material, has absorption sepage, quick-acting haemostatic powder, prevents and treats adhesion, promote wound
Face healings etc. act on.Sthptic sponge is generally used for the exudative hemostasis of blood capillary during internal organs operation clinically.Sthptic sponge
Clinical practice includes general surgery, cardiovascular surgery, plastic surgery, Urology Surgery, orthopaedics, department of dermatologry, Department of B urn, gynecological, mouth
The section office such as chamber section, ophthalmology.
When sthptic sponge contacts with wound surface, physics and physiological mechanism is mainly utilized to stop blooding.Physics hemostasis is mainly
By mechanical pressure sealing blood vessels opening, biological hemostatic is by utilizing sthptic sponge to adsorb, assemble and activate platelet, thus
Activate thrombin, thrombin and fibrin.Although, sthptic sponge in theory has good hemostatic capability, but actual
The hemostasis of upper sthptic sponge need to rely on can be stable adhere to wound surface and the powerful ability absorbing sepage.This two side
The performance in face, all can cause sthptic sponge to make troubles to medical personnel on Clinical practice if any on the one hand disappearance.Existing city
Sthptic sponge entirety on field is all a Rotating fields, is difficult to take into account the performance of these two aspects simultaneously.Such as, absorbent is good
Product, adhesiveness would generally lack, and product easily produces " sending out drift " phenomenon, when wound surface has a large amount of oozing of blood when, sthptic sponge
Slip on wound surface surface；The product that adhesion property is good, then would generally lose part absorbent, have a large amount of transudate when running into
Time, it is likely that in time transudate cannot be absorbed, cause haemostatic effect bad.
Summary of the invention
Offer is provided and a kind of there is the sthptic sponge of two-layer composite, manufacture method and mould thereof, this product
Not only there is excellent adhesion property and simultaneously but also possessed good absorption sepage performance；And its manufacture method convenient and efficient, have relatively
Good market prospect.
For reaching above-mentioned purpose, the concrete technical scheme of the present invention is as follows:
A kind of two-layer compound sthptic sponge, it is characterised in that: include liquid-adsorption layer and adhesion layer, described adhesion layer is provided with logical
Hole.
For coordinating patient's wound shape, described through hole is preferably circular, similar round or square.
For the blood making liquid-adsorption layer ooze out in quickly absorbing wound, prevent a large amount of blood from oozing out into adhesion layer, reduce viscous
The viscosity of attached layer, the thickness of described adhesion layer is 2 ~ 20mm.
A kind of mould making two-layer compound sthptic sponge, including die body, is provided with boss, described boss in described die body
Being positioned at die body center, the shape of described boss is adaptive with described through hole, and described boss is formed around corresponding groove.
For coordinating the thickness of adhesion layer, described depth of groove is 2 ~ 20mm.
A kind of manufacture method making two-layer compound sthptic sponge, comprises the steps:
The first step, taking collagen protein stock solution and being diluted with water to collagen protein stock solution concentration is between 0.05% ~ 0.5%, by above-mentioned molten
Liquid, is cast in the groove of mould so that the liquid level of collagen solution is contour with boss；Collagen protein stock solution extract from cattle with
One in tendon, pig heel string, horse heel string, Corii Bovis seu Bubali, Corii Sus domestica, Corium Equi；
Second step, puts into mould refrigerating chamber and freezes in-10 DEG C ~-60 DEG C；
3rd step, takes collagen protein stock solution, is diluted with water to concentration 0.3% ~ 1.0%, will add in collagen solution described in the 3rd step
Cross-linking agent mix homogeneously.
4th step, takes out mould from refrigerating chamber, is cast in mould by the mixed liquor of cross-linking agent Yu collagen protein；Cast height
Degree is 1 ~ 10mm；
5th step, is placed again into refrigerating chamber by the mould in the 3rd step and freezes in-10 DEG C ~-60 DEG C.
6th step, puts into vacuum freeze drier by the mould of the 5th step, and lyophilization obtains two-layer compound sthptic sponge.
For improve cross-linking effect, with this improve the mechanical strength of collagen protein, resistance to enzymolysis, absorbency, etc. performance.Described
Cross-linking agent is the one in glutaraldehyde, formaldehyde, epoxide, genipin.Described crosslinker concentration is 0.0001% ~ 0.01%
The present invention, by arranging through hole on adhesion layer, avoids and directly contacts wound, prevent the body fluid that wound oozes out (such as blood
Liquid) reduce the viscosity of adhesion layer, cause " send out drift " phenomenon；Adhesion layer is close to wound periphery, the body fluid that now wound oozes out simultaneously
The liquid-adsorption layer being attached layer outer (through hole just to) absorbs, and is substantially reduced the body fluid impact on adhesion layer so that two-layer compound is only
Sea of blood silk floss can persistently be adjacent at wound, is unlikely to be shifted over, and reduces haemostatic effect.The present invention has imbibition and preferably concurrently
Adhesion property, is particularly suitable for hemorrhage more wound.In addition the supporting manufacture method simple operation of the present invention, has preferably
Marketing prospect.
The present invention is freezed so that sthptic sponge forms double-layer structure, and the thing of double-layer structure by two step cast and secondary
Reason form and chemical composition are different from.Material selected by adhesion layer of the present invention i.e. subsides for meeting water, can be formed irregular solidifying
The collagen protein of glue, gelatin, chitosan.Subside formation gel state thing when the sepage of adhesion layer with wound surface surrounding tissue contacts
Matter, on the one hand makes liquid-adsorption layer directly contact absorption sepage with wound surface；On the other hand, adhesion layer formation gel state material provides
Adhesive capacity good between product and tissue.Avoid the product when wound exudate is too much and " sending out drift " phenomenon occurs.The present invention holds concurrently
Tool imbibition and preferably adhesion property, be particularly suitable for hemorrhage more wound.In addition the manufacture method operation that the present invention is supporting
Convenient, there is preferably marketing prospect.Illustrate with detailed description of the invention the present invention to be done to explain further below by way of accompanying drawing
State.
Accompanying drawing explanation
Fig. 1 be the present invention be the structural representation of two-layer compound sthptic sponge；
Fig. 2 be the present invention be the profile of two-layer compound sthptic sponge；
Fig. 3 be the present invention be make two-layer compound sthptic sponge mould profile.
Label declaration
Two-layer compound sthptic sponge 10, liquid-adsorption layer 11, adhesion layer 12, through hole 13, mould 20, die body 21, boss 22, groove 23.
Detailed description of the invention
Definition explanation:
Collagen solution: collagen solution preparation be with cattle heel string pig heel string, horse heel string etc. as raw material, by enzymolysis,
Purification high purity Ι Collagen Type VI, the collagen protein prepared maintains the triple helix structure of protein, thus has work
Property, tropocollagen molecule can activate intrinsic coagulation pathway, activates intrinsic coagulation by compressing wound surface in use, only to reach
Blood effect, collagen protein also degradable by aminoacid thus is absorbed by human body.
Crosslinking: multiple molecules (aminoacid in collagen protein) are mutually bonded the relatively stable molecule being cross-linked into network structure
(build molecule) reacts.This reaction makes the macromole of line style or slight branched chain type be transformed into tridimensional network, improves with this
The mechanical strength of collagen protein, resistance to enzymolysis, absorbency, etc. performance.
Embodiment
A kind of two-layer compound sthptic sponge 10, including liquid-adsorption layer 11 and adhesion layer 12, described adhesion layer 12 is middle is through
Structure, the most described adhesion layer 12 is provided with through hole 13.Described through hole 13 is preferably circular, similar round or square.Described adhesion
The thickness of layer 12 is preferably 2 ~ 20mm.
A kind of mould 20 making two-layer compound sthptic sponge, including die body 21, described die body 21 is for having certain depth
Housing, be provided with boss 22 in described die body 21, described boss 22 is positioned at die body 21 center, the shape of described boss 22
Adaptive with through hole 13, correspondingly, described boss 22 surrounding be shaped as groove 23.Described groove 23 degree of depth is 2cm.
A kind of manufacture method making two-layer compound sthptic sponge:
The first step, takes and is extracted from the collagen stock solution of cattle heel string (or the one in pig heel string, horse heel string, Corii Bovis seu Bubali, Corii Sus domestica, Corium Equi) and adds
It is 0.2% that water is diluted to concentration, is that 0.2% collagen solution is cast at the groove 23 of mould 20 by concentration, and collagen protein is molten
The liquid level of liquid is contour with boss 22；Described collagen protein stock solution can be selected for meeting water can form the collagen protein of amorphous state or shell gathers
Sugar juice replaces.
Second step, puts into mould 20 refrigerating chamber (refrigerator etc.), is freezed by collagen solution in-40 DEG C；
3rd step, takes the collagen stock solution being extracted from cattle heel string, and being diluted with water to concentration is 0.5%；To the collagen solution of 0.5%
Middle addition glutaraldehyde (or the one in formaldehyde, epoxide, genipin), making glutaraldehyde concentration is 0.001%, by collagen protein
Solution is mixed homogeneously with glutaraldehyde；
4th step, takes out the mould 20 in second step from refrigerating chamber, is positioned on hypothermia operation table, carries out second time and pours into a mould:
Collagen protein and the glutaraldehyde mixed liquor of 0.001% by 0.5% are cast in mould 20；Cast height is 1 ~ 10mm；
5th step, puts into refrigerating chamber (refrigerator etc.) by the mould 20 in the 3rd step, with-40 DEG C by freezing solution.
6th step, solution previous step freezed is put in vacuum freeze drier together with mould, and footpath freezing is done
Dry obtain two-layer compound sthptic sponge.
The using method of the present invention: the present invention be liquid-adsorption layer 11 outwardly, adhesion layer 12 uses inwardly, and is directed at by through hole 13
At the wound of patient, adhesion layer 12 is close to wound periphery.
Due to the setting of through hole 13 on adhesion layer 12 of the present invention, avoid and directly contact wound, prevent the body that wound oozes out
Liquid (such as blood) reduces the viscosity of adhesion layer, causes " sending out drift " phenomenon；Adhesion layer 12 is close to wound periphery simultaneously, and now wound oozes
The body fluid gone out has been attached the liquid-adsorption layer 11 of layer 12 outer (through hole 13 just to) and has absorbed, and is substantially reduced the body fluid shadow to adhesion layer 12
Ring so that two-layer compound sthptic sponge can persistently be adjacent at wound, is unlikely to be shifted over, reduce haemostatic effect.This
Bright have imbibition and preferably adhesion property concurrently, be particularly suitable for hemorrhage more wound.
Above example is only in order to illustrate technical scheme and unrestricted, and those of ordinary skill in the art are to this
Other amendment or equivalents that bright technical scheme is made, without departing from the spirit and scope of technical solution of the present invention,
All should contain in scope of the presently claimed invention.
Claims (10)
1. a two-layer compound sthptic sponge, it is characterised in that: include liquid-adsorption layer and adhesion layer, described adhesion layer is provided with logical
Hole.
2. a kind of two-layer compound sthptic sponge as claimed in claim 1, it is characterised in that: described through hole is preferably circular, class
Circular or square.
3. two-layer compound sthptic sponge as claimed in claim 1 a kind of, it is characterised in that: the thickness of described adhesion layer is 2 ~
20cm。
4. the mould making two-layer compound sthptic sponge, it is characterised in that: include die body, be provided with convex in described die body
Platform, described boss is positioned at die body center, and the shape of described boss is adaptive with described through hole, and described boss is formed around accordingly
Groove.
5. the method making two-layer compound sthptic sponge, it is characterised in that comprise the steps:
The first step, makes adhesion layer: collagen protein stock solution is cast in the groove of mould so that the liquid level of collagen solution
Contour with boss；
Second step, puts into refrigerating chamber by mould and freezes；
3rd step, configuration collagen protein stock solution and the mixed solution of cross-linking agent；
4th step, makes liquid-adsorption layer: take out the mould in second step, be cast in mould by the mixed solution in the 3rd step；
5th step, puts into refrigerating chamber by the mould in the 4th step and freezes；
6th step, puts into vacuum freeze drier by the mould of the 5th step, and lyophilization obtains two-layer compound sthptic sponge.
A kind of method making two-layer compound sthptic sponge, it is characterised in that: described adhesion layer institute
The material selected is collagen protein stock solution, gelatin or chitosan.
A kind of method making two-layer compound sthptic sponge, it is characterised in that: described adhesion layer institute
The selection of material concentration 0.05% ~ 0.5%.
A kind of method making two-layer compound sthptic sponge, it is characterised in that: in described 3rd step
Procollagen solution concentration 0.3% ~ 1.0%.
A kind of method making two-layer compound sthptic sponge, it is characterised in that: described cross-linking agent is
Glutaraldehyde, formaldehyde, epoxide or genipin.
A kind of method making two-layer compound sthptic sponge, it is characterised in that:. selected friendship
Connection agent concentration is 0.0001% ~ 0.01%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610836368.0A CN106237371A (en) | 2016-09-21 | 2016-09-21 | Two-layer compound sthptic sponge, the mould making two-layer compound sthptic sponge and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610836368.0A CN106237371A (en) | 2016-09-21 | 2016-09-21 | Two-layer compound sthptic sponge, the mould making two-layer compound sthptic sponge and method |
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| Publication Number | Publication Date |
|---|---|
| CN106237371A true CN106237371A (en) | 2016-12-21 |
Family
ID=57599965
Family Applications (1)
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|---|---|---|---|
| CN201610836368.0A Pending CN106237371A (en) | 2016-09-21 | 2016-09-21 | Two-layer compound sthptic sponge, the mould making two-layer compound sthptic sponge and method |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107007870A (en) * | 2017-03-03 | 2017-08-04 | 北京博辉瑞进生物科技有限公司 | A kind of biological hemostatic material, preparation method and applications |
| CN107469132A (en) * | 2017-07-26 | 2017-12-15 | 中国科学院长春应用化学研究所 | A kind of styptic sponge/medicine-loading fibre felt/styptic sponge compound and preparation method thereof |
| CN107899080A (en) * | 2017-11-30 | 2018-04-13 | 振德医疗用品股份有限公司 | A kind of dermis restoration stent preparation method |
| CN107899081A (en) * | 2017-11-30 | 2018-04-13 | 振德医疗用品股份有限公司 | A kind of dermis restoration stent |
| CN108578067A (en) * | 2018-03-21 | 2018-09-28 | 振德医疗用品股份有限公司 | A kind of eye wrapping application and preparation method thereof |
| CN111202867A (en) * | 2020-03-05 | 2020-05-29 | 山东陆海蓝圣生物科技股份有限公司 | High-water-absorption and water-resistance double-layer composite hemostatic sponge and preparation method thereof |
| CN114350009A (en) * | 2021-10-29 | 2022-04-15 | 北京健康广济生物技术有限公司 | Hemostatic sponge and preparation method thereof |
| CN116785493A (en) * | 2023-07-13 | 2023-09-22 | 南京普立蒙医疗科技有限公司 | Hollow composite double-layer nasal cavity hemostatic sponge, preparation method and application thereof |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107007870A (en) * | 2017-03-03 | 2017-08-04 | 北京博辉瑞进生物科技有限公司 | A kind of biological hemostatic material, preparation method and applications |
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| CN107469132A (en) * | 2017-07-26 | 2017-12-15 | 中国科学院长春应用化学研究所 | A kind of styptic sponge/medicine-loading fibre felt/styptic sponge compound and preparation method thereof |
| CN107899080A (en) * | 2017-11-30 | 2018-04-13 | 振德医疗用品股份有限公司 | A kind of dermis restoration stent preparation method |
| CN107899081A (en) * | 2017-11-30 | 2018-04-13 | 振德医疗用品股份有限公司 | A kind of dermis restoration stent |
| CN108578067A (en) * | 2018-03-21 | 2018-09-28 | 振德医疗用品股份有限公司 | A kind of eye wrapping application and preparation method thereof |
| CN111202867A (en) * | 2020-03-05 | 2020-05-29 | 山东陆海蓝圣生物科技股份有限公司 | High-water-absorption and water-resistance double-layer composite hemostatic sponge and preparation method thereof |
| CN111202867B (en) * | 2020-03-05 | 2022-04-22 | 山东陆海蓝圣生物科技股份有限公司 | High-water-absorption and water-resistance double-layer composite hemostatic sponge and preparation method thereof |
| CN114350009A (en) * | 2021-10-29 | 2022-04-15 | 北京健康广济生物技术有限公司 | Hemostatic sponge and preparation method thereof |
| CN116785493A (en) * | 2023-07-13 | 2023-09-22 | 南京普立蒙医疗科技有限公司 | Hollow composite double-layer nasal cavity hemostatic sponge, preparation method and application thereof |
| CN116785493B (en) * | 2023-07-13 | 2024-04-05 | 南京普立蒙医疗科技有限公司 | Hollow composite double-layer nasal cavity hemostatic sponge, preparation method and application thereof |
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