CN106236695A - One peptide species anti-acne repairs essence and preparation method thereof - Google Patents
One peptide species anti-acne repairs essence and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a peptide species anti-acne and repair essence and preparation method thereof, this essence, rich in beauty treatment polypeptide moiety, mainly includes following components: hexapeptide 9, tetrapeptide 30, antibacterial peptide, penetrating peptide, Aloe vulgaris, dairy yeast, butanediol, glycerol, hyaluronate sodium, squalane, tocopherol, Xanthan gum are former, stearic acid, Laurel spring polyethers 3, phenoxyethanol, methyl hydroxybenzoate, ethyl hydroxybenzoate.The total weight percent of hexapeptide 9, tetrapeptide 30, antibacterial peptide, penetrating peptide four kinds beauty treatment polypeptide is 10～30%.Four kinds of beauty treatment polypeptide of this essence are the functional components that this product is main.There are some researches show that hexapeptide 9, tetrapeptide 30, antibacterial peptide have the strongest antibacterial, anti-acne effect, and penetrating peptide has good transdermal effect, use this product can quickly dispel facial acne and life-time service can repair face pockmark.
Description
Technical field
The present invention relates to cosmetic field, be specifically related to a peptide species anti-acne and repair essence and preparation method thereof.
Background technology
Pox is being commonly called as of acne, is again " comedo ", " skin sore " or " acne ", is owing to hair follicle and sebaceous gland are blocked, sent out
The scorching a kind of dermatosis caused.During adolescence, internal hormone can grow by stimulating hair, promotes smegma more heavy wool
Therefore fat, hair and sebaceous gland pile up many materials, make oils and fats and antibacterial attachment, cause the reaction of red swelling of the skin.Due to this
Symptom is common in youth of both sexes, so being referred to as " comedo ".
The method of existing anti-acne has a variety of, 1, as laser therapy comedo method be to be contaminated by the high intensity of specific wavelength
Material laser irradiates, energy rapid damage propanoic acid comedo bacillus, effectively suppresses bacterial reproduction, eliminates its stimulation to organizing and destruction
Effect, but the effect of laser therapy is too strong, and also simply physical method destroys pox, it is impossible to fundamentally anti-acne；2, profit
Composition anti-acne is mixed with plant with some natural plant components, Chinese medicinal ingredients or Chinese medicines such as Aloe, Fructus Cucumidis sativi, lavandula angustifoliaes, existing
This anti-acne method safety, regulation of skin oils and fats can be played thus the effect of fundamentally anti-acne, but often use this
When planting natral plant ingredients anti-acne, the marking after time length, anti-acne is difficult to remove completely；3, utilize salicylic acid, Bo Nisong, fill in
Some Western medicine such as meter Song remove pox, and the side effect of Western medicine is the strongest.
Polypeptide is formed (50 aminoacid hereinafter referred to as polypeptide, 50 aminoacid are referred above to albumen) by aminoacid,
It is the middle hydrolyzate of protein, is also the constituent of human body cell.Numerous studies show, protein is the completeest after taking in
All-hydrolytic becomes aminoacid, and major part is absorbed with the form of peptide, the most also finds, the absorbed speed of polypeptide is than the ammonia with composition
Base acid wants fast.
Polypeptide is mainly endogenous polypeptide or other natural polypeptidess, and its structure understands, mechanism of action clear and definite, quality control water
Flush and be bordering on traditional small molecule chemicals, and close to albumen in activity, gathered the excellent of conventional chemicals and albumen
Point.
Beauty treatment polypeptide is the polypeptide that a class has beauty functions.The condensation substance being made up of multiple aminoacid is (the most common
Beauty treatment polypeptide is 2-10 amino condensation compound), but it is because amino acid classes, sequence difference, its function is entirely different.
Beauty treatment polypeptide because human body is not injured, effect is obvious, mechanism of action is clear, the most applied more than 20
Year, all adding (Estee Lauder, perfume (or spice) how, Christian Dior, Lancome etc.), and China is the most at the early-stage for a lot of famous products, and market should
Consumption is also little, and a lot of products are the most all to propagandize；But along with progressively adding of state food pharmaceuticals administration general bureau's facial film supervision
By force, market is bound to progressively specification.
Summary of the invention
The present invention has considered shortcoming and the deficiency that existing anti-acne technology exists, and it is an object of the invention to carry
Go out that a kind of anti-acne effect is more preferable, responding time is shorter, natural safe polypeptide anti-acne repairs essence.This polypeptide anti-acne repairs essence
China's liquid, with multiple antibacterial polypeptide as main active, plays synergism, plays antibacterial, the purpose of antiinflammatory, be finally reached and dispel
The effect of pox.It is a further object to provide above-mentioned polypeptide anti-acne and repair the preparation method of essence.
The present invention to achieve these goals, by the following technical solutions:
One peptide species anti-acne reparation essence, weight percentage, including following components:
As preferably, said composition by mass percentage, the component including following:
As preferably, said composition includes following component by mass percentage:
As further preferably, described hexapeptide-9, tetrapeptide-30, antibacterial peptide, the gross weight percentage of penetrating peptide four kinds beauty treatment polypeptide
Ratio is 10～30%.
As further preferably, described hexapeptide-9, tetrapeptide-30, antibacterial peptide, penetrating peptide four kinds beauty treatment polypeptide purity at 95-
99%.
The present invention is in order to realize above-mentioned second purpose, by the following technical solutions:
One peptide species anti-acne repairs the preparation method of essence, comprises the following steps:
1) by former to water, Aloe vulgaris, butanediol, glycerol, hyaluronate sodium, squalane, tocopherol, Xanthan gum, stearic acid, Laurel
Spring polyethers-3, phenoxyethanol, methyl hydroxybenzoate, ethyl hydroxybenzoate add in retort, open stirring, are heated to 75～80 DEG C, stirring
It is uniformly dispersed；
2) cooling circulating water is opened, stirring cooling, when temperature is down to 40～45 DEG C, dairy yeast is added in retort, homogenizing 1
Minute, stirring and dissolving is complete；
3) continue stirring and be cooled to less than 37 DEG C, hexapeptide-9, tetrapeptide-30, antibacterial peptide, penetrating peptide are added in retort, homogenizing
2-3 minute, stirring and dissolving was complete, terminated.
Further object is that and provide polypeptide anti-acne to repair essence effect in terms of antibacterial, anti-acne.
The present invention also provides for polypeptide anti-acne and repairs essence and have and dispel facial acne and life-time service can repair face pockmark
Effect.
In the present invention, four peptide species are main additive.Wherein:
Hexapeptide-9 is a kind of beauty treatment polypeptide using solid-phase synthesis to synthesize, be characterized in purity high, non-stimulated to human body,
Clear mechanism, hexapeptide-9 has good effect dispelling pox India side face, additionally, hexapeptide-9 also to have promotion dermal collagen raw
The regeneration of one-tenth, true epidermis articulamentum, promoting epidermization and effect of differentiation[1,2]。
Tetrapeptide-30 is a kind of beauty treatment polypeptide using solid-phase synthesis to synthesize, and is characterized in that purity is high, stingless to human body
Sharp, beauty treatment clear mechanism, tetrapeptide-30 has antiinflammatory, repairing effect, can significantly reduce the damage of acne[3,4]。
Antibacterial peptide is a kind of polypeptide using solid-phase synthesis to synthesize, and is characterized in having antibacterium, fungus, virus etc. many
Plant biological function, product for resolving poxes has good application prospect[5]。
Penetrating peptide: help active substance to arrive subcutaneous through skin.Transdermal Toplink creates the skin that a transience is open
Skin passage, through corneocyte arrive living Epidermis, it is also possible to by corneocyte gap arrive living Epidermis[6]。
Component used in the present invention, can commercially buy, belong to existing product.
Present invention have the advantage that
1) this product add antibacterial, antiinflammatory polypeptide moiety is higher, additionally, the interpolation of penetrating peptide, these effective ingredient can be made fast
Speed enters skin, and formula is contained within the natural extracts such as Aloe vulgaris, has quick flat and comforts skin, efficient moisturizing, tender
The features such as skin nourishing.It is smooth, fine and smooth that after using 7 days continuously, small pox substantially diminishes, skin becomes.
2) polypeptide anti-acne of the present invention repairs essence product safety, effectively；And preparation method is simple, process stabilizing, can promote should
With.
Accompanying drawing explanation
Fig. 1: polypeptide anti-acne repairs the change of recipient site L* value during essence uses
Detailed description of the invention
List polypeptide anti-acne of the present invention with table 1 below and repair each composition weight percentage of essence embodiment 1 embodiment 3
Content
Aforementioned polypeptides anti-acne repairs the preparation method of essence, comprises the following steps: water, Aloe vulgaris, butanediol, sweet
Oil, hyaluronate sodium, squalane, tocopherol, Xanthan gum are former, stearic acid, Laurel spring polyethers-3, phenoxyethanol, methyl hydroxybenzoate, oxybenzene
Ethyl ester adds in retort, opens stirring, is heated to 75～80 DEG C, and dispersed with stirring is uniform；Opening cooling circulating water, stirring is lowered the temperature,
When temperature is down to 40～45 DEG C, being added by dairy yeast in retort, homogenizing 1 minute, stirring and dissolving is complete；Continue stirring cold
But to less than 37 DEG C, hexapeptide-9, tetrapeptide-30, antibacterial peptide, penetrating peptide are added in retort, homogenizing 2-3 minute, stirring and dissolving
Completely, terminate.
List polypeptide anti-acne of the present invention with table 2 below and repair each composition weight percentage of essence embodiment 4 embodiment 6
Content
Aforementioned polypeptides anti-acne repairs the preparation method of essence, comprises the following steps: water, Aloe vulgaris, butanediol, sweet
Oil, hyaluronate sodium, squalane, tocopherol, Xanthan gum are former, stearic acid, Laurel spring polyethers-3, phenoxyethanol, methyl hydroxybenzoate, oxybenzene
Ethyl ester adds in retort, opens stirring, is heated to 70～75 DEG C, and dispersed with stirring is uniform；Opening cooling circulating water, stirring is lowered the temperature,
When temperature is down to 40～42 DEG C, being added by dairy yeast in retort, homogenizing 1 minute, stirring and dissolving is complete；Continue stirring cold
But to less than 37 DEG C, hexapeptide-9, tetrapeptide-30, antibacterial peptide, penetrating peptide are added in retort, homogenizing 2-3 minute, stirring and dissolving
Completely, terminate.
List polypeptide anti-acne of the present invention with table 3 below and repair each composition weight percentage of essence embodiment 7 embodiment 9
Content
Aforementioned polypeptides anti-acne repairs the preparation method of essence, comprises the following steps: water, Aloe vulgaris, butanediol, sweet
Oil, hyaluronate sodium, squalane, tocopherol, Xanthan gum are former, stearic acid, Laurel spring polyethers-3, phenoxyethanol, methyl hydroxybenzoate, oxybenzene
Ethyl ester adds in retort, opens stirring, is heated to 75～78 DEG C, and dispersed with stirring is uniform；Opening cooling circulating water, stirring is lowered the temperature,
When temperature is down to 40～42 DEG C, being added by dairy yeast in retort, homogenizing 1 minute, stirring and dissolving is complete；Continue stirring cold
But to less than 37 DEG C, hexapeptide-9, tetrapeptide-30, antibacterial peptide, penetrating peptide are added in retort, homogenizing 2-3 minute, stirring and dissolving
Completely, terminate.
Properties of product evaluation test of the present invention is as follows:
One, embodiment 1-9 carries out anti-acne effect test:
1, tester selects: select 180 slight, moderate acne patients, age 18-35 year between, be divided into 9 groups, often organize 20
People.
2, using method: the most each use 1 time every day, takes the anti-acne reparation essence of the present invention after face cleaning and is applied in right amount
Face, product uses one month continuously, does not use other anti-acne class cosmetics during test.
3, criterion and result (table 4):
Recovery from illness: acne disappears substantially；
Effective: acne is obviously improved, remain a small amount of acne, pimple；
Effective: acne has a certain degree of improvement；
Invalid: without improving
Table 4 anti-acne experimental result
| Group | Recovery from illness | Effective | Effectively | Without improving |
| Embodiment 1 | 5 | 11 | 4 | 1 |
| Embodiment 2 | 5 | 8 | 5 | 2 |
| Embodiment 3 | 4 | 10 | 6 | 0 |
| Embodiment 4 | 6 | 10 | 4 | 0 |
| Embodiment 5 | 7 | 12 | 1 | 0 |
| Embodiment 6 | 6 | 10 | 3 | 1 |
| Embodiment 7 | 9 | 8 | 3 | 0 |
| Embodiment 8 | 10 | 9 | 1 | 0 |
| Embodiment 9 | 12 | 8 | 0 | 0 |
Result: in 180 examples, uses what product of the present invention fully recovered to account for 35.6%, and effective accounts for 47.8%, effectively accounts for
15%, a total of efficiency is 98.4%, and untoward reaction occurs in none example of whole experimenters.
Two, embodiment 9 is carried out whitening repairing effect evaluation
The polypeptide anti-acne that this experimental selection implements to provide in 9 is repaired essence and is tested.
Select 30 ages 23～35 years old healthy women, measure and record face skin color, then provide testedization
Cosmetic, study subject uses polypeptide anti-acne to repair essence sample continuously.After using 7d, 14d, 21d, 30d continuously, then measure each
Efficacy measures.Inquiry volunteer feels and with or without allergic phenomena etc. after using given the test agent simultaneously, right before and after recording self
Ratio.After using polypeptide anti-acne to repair before essence 1d and use, 7d, 14d, 21d, 30d utilize Lab colorimeter system spectral luminosity
The change of measurement amount skin color, follow-on test 3 times, average.Data process and use spss statistical software to carry out pairing t inspection
Test, have significance with P < 0.05.
The situation of change of recipient site skin colourity L* value before and after test: skin colourity L* value is the biggest, represents skin color
The most shallow.7d after product use, skin colourity L* value just has the trend of increase, from 14d, is just significantly greater than water before test
Flat (P < 0.05) (see Fig. 1, data are shown in Table 5), L* value uses the prolongation of time to present the trend being gradually increased along with product.
Table 5 polypeptide anti-acne repairs the change of recipient site L* value during essence uses
| Time/week | Comparison | 1 | 2 | 3 | 4 |
| L* value | 60.30 | 75.20 | 80.35 | 88.70 | 90.12 |
In sum, this essence product has whitening reparation skin, effect of bright color.
Three, polypeptide anti-acne repairs essence stability test result
According to People's Republic of China's light industry standard QB/T 2,660 2004 to made containing hexapeptide-9, tetrapeptide-30,
Antibacterial peptide, the polypeptide anti-acne of penetrating peptide are repaired essence and are carried out sense organ, physicochemical property test, and result is as shown in table 7.Can by table 7
Knowing, polypeptide anti-acne is repaired the testing result of essence color, turbidity, cold-resistant heat resistant test and acid-base value and is all met the China people
The sense organ of republic's light industry standard QB/T 2,660 2004, physical and chemical index specify, show that adding four kinds repaiies polypeptide anti-acne
The quality index of multiple essence is substantially without impact.
Table 7 polypeptide anti-acne repairs essence Detection of Stability result
| Project | Result |
| Outward appearance | Uniform liquid. free from foreign meter |
| Heat-resistant experiment | (40 ± 1) DEG C keep 24h, recover to room temperature front with test without obvious Traits change |
| Cold-resistant experiment | (5 ± 1) DEG C keep 24h, recover to room temperature front with test without obvious Traits change |
| pH | It is about 7.0 |
The polypeptide anti-acne that example 1, embodiment 3, embodiment 5, embodiment 7, embodiment 9 prepare is repaired essence product,
Carrying out Experimental comparison with existing anti-acne essence product, experiment condition is: 60 women of volunteer, age 18-35 year, every angel
With 1 time, use 28 days continuously.Shown in experimental result such as following table (table 8):
Table 8 polypeptide anti-acne repairs the contrast of essence and existing Deacne pack
In order to save length, the present invention only enumerates section Example and experiment thereof, it practice, other technologies scheme of the present invention
Also close or identical beneficial effect can be reached.
List of references
[1] Zhong Xing, Guo Jianwei, Cheng Qiugui. win peptide application in facial film and latest developments [J]. household chemicals science,
2012,35 (11): 35-38.
[2]Papini A M.Cosmetics towards peptide-based cosmeceutics[J]
.ChimicaOggi/Che-mistry Today,2010,28(6):3-4
[3] yellow Yadong. biologically active polypeptide application [c] in medical cosmetology. the 10th south east asia medical cosmetology is academic
Conference collection of thesis, 2006:14 17
[4] Wang Hongxiang. poplar is along equality. and medicinal plant extract combines the progress [J] of antibacterial peptide anti-acne effect. detergents and cosmetic
Product science, 2014,37, (10)
[5] Xiao Mingzhu, gold Xiaobao, Zhu Jiayong. antibacterial peptide antioxidation mechanism and application prospect thereof. Food Science, 312,
2010, vol, 31, No.11.
[6] Zhou Huahua, Dong Jian. western medical science in July, 2012 volume 24 the 7th phase Med J West China, July
2012.Vol.24.No.7.
Claims (10)
1. a peptide species anti-acne repairs essence, it is characterised in that weight percentage is calculated, including following components:
A peptide species anti-acne the most according to claim 1 repairs essence, it is characterised in that weight percentage
Calculate, including following components:
A peptide species anti-acne the most according to claim 2 repairs essence, it is characterised in that weight percentage
Calculate, including following components:
A peptide species anti-acne the most according to claim 1 repairs essence, it is characterised in that weight percentage
Calculate, including following components:
A peptide species anti-acne the most according to claim 1 repairs essence, it is characterised in that weight percentage
Calculate, including following components:
A peptide species anti-acne the most according to claim 1 repairs essence, it is characterised in that weight percentage
Calculate, including following components:
7. repair essence according to the peptide species anti-acne described in claim 1-6 any one, it is characterised in that described six
The total weight percent of peptide-9, tetrapeptide-30, antibacterial peptide, penetrating peptide four kinds beauty treatment polypeptide is 10～30%.
8. repair essence according to the peptide species anti-acne described in claim 1-6 any one, it is characterised in that described six
The purity of peptide-9, tetrapeptide-30, antibacterial peptide, penetrating peptide four kinds beauty treatment polypeptide is at 95-99%.
9. preparing the method that the polypeptide anti-acne described in claim 1～8 any one claim repairs essence, it is special
Levying and be, the method comprises the following steps:
1) by former to water, Aloe vulgaris, butanediol, glycerol, hyaluronate sodium, squalane, tocopherol, Xanthan gum, stearic acid, Laurel
Spring polyethers-3, phenoxyethanol, methyl hydroxybenzoate, ethyl hydroxybenzoate add in retort, open stirring, are heated to 75～80 DEG C, stirring
It is uniformly dispersed；
2) cooling circulating water is opened, stirring cooling, when temperature is down to 40～45 DEG C, dairy yeast is added in retort, homogenizing 1
Minute, stirring and dissolving is complete；
3) continue stirring and be cooled to less than 37 DEG C, hexapeptide-9, tetrapeptide-30, antibacterial peptide, penetrating peptide are added in retort, homogenizing
2-3 minute, stirring and dissolving was complete, to obtain final product.
10. polypeptide anti-acne described in claim 1 is repaired essence and is being prepared antibacterial, anti-acne, dispelling facial acne and make for a long time
With the application in the cosmetics that can repair face pockmark.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125706A (en) * | 2018-09-20 | 2019-01-04 | 深圳市维琪医药研发有限公司 | A kind of peptide composition for being effectively improved acne and repairing skin lesion |
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| CN109125706A (en) * | 2018-09-20 | 2019-01-04 | 深圳市维琪医药研发有限公司 | A kind of peptide composition for being effectively improved acne and repairing skin lesion |
| CN111166692A (en) * | 2020-03-18 | 2020-05-19 | 深圳市百吉因生物科技有限公司 | A composition with high moisture keeping effect |
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Application publication date: 20161221 |