CN106214718A - A kind of moxa-moxibustion cream and its preparation method and application - Google Patents
A kind of moxa-moxibustion cream and its preparation method and application Download PDFInfo
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- CN106214718A CN106214718A CN201610708042.XA CN201610708042A CN106214718A CN 106214718 A CN106214718 A CN 106214718A CN 201610708042 A CN201610708042 A CN 201610708042A CN 106214718 A CN106214718 A CN 106214718A
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- folium artemisiae
- artemisiae argyi
- moxa
- moxibustion cream
- moxibustion
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- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The present invention relates to the traditional Chinese medical science and relevant medicine field, in particular to a kind of moxa-moxibustion cream and its preparation method and application.By weight, described moxa-moxibustion cream is mainly made up of following material component: Folium Artemisiae Argyi 80~120 parts and Folium Artemisiae Argyi 2~5.5 parts.This moxa-moxibustion cream, as external used medicine, can be used for treating arthrosis and cold-evil caused a disease.Avirulence, has no side effect, and will not develop immunity to drugs, abundant raw material source, and production cost is low, and need not medical knowledge and the Therapeutic Method of complexity and can use, and can be described as the standing medicine of family, also can solve the situation of outlying district shortage of medical services and medicines.
Description
Technical field
The present invention relates to the traditional Chinese medical science and relevant medicine field, in particular to a kind of moxa-moxibustion cream and preparation method thereof and should
With.
Background technology
Moxa-moxibustion is the moxibustion therapy in Chinese medicine acupuncture therapy.Point uses moxa cone that Folium Artemisiae Argyi makes, moxa roll is main, the cave of the human body that fire-cures
Position is to reach a kind of naturopathy of promoting health and curing diseases.China in ancient times, Folium Artemisiae Argyi has been important people's livelihood plant the most.It is generally used for pin
" moxibustion " of moxibustion.So-called acupuncture is divided into two parts in fact." pin " is exactly to take acupuncture acupoint, and " moxibustion " is exactly to take Folium Artemisiae Argyi to light it
After go to smoke, scald acupoint, acupoint is heated no doubt stimulation, but is not any paper or grass has been lighted and can have been used as " moxibustion ".Chinese mugwort
The abnormal smells from the patient of grass has played certain effect certainly the most simultaneously.When the method for folks of china cupping treats rheumatism, with Folium Artemisiae Argyi
As fuel effect more preferably.
Moxibustion therapy is in the history of the existing two thousand years of China, and its therapeutic effect is confirmed by countless clinical practices.And to it
The understanding of mechanism, is still a fan not solved.At present, in the prior art, moxa-moxibustion still uses conventional methods and carries out, i.e. people
Body Different Acupoint is lighted Folium Artemisiae Argyi and is realized moxa-moxibustion effect, but this mode operates inconvenience, and effective ingredient contained in Folium Artemisiae Argyi
Can not be absorbed by the body fully, and then make moxa-moxibustion effect less notable, therefore provide that a kind of process is processed, effectively become
Dividing rich content and moxibustion product safe and convenient to use is that current this area has a to be solved technical problem.
In view of this, the special proposition present invention.
Summary of the invention
It is an object of the invention to provide a kind of moxa-moxibustion cream, to solve the problems referred to above.
A kind of moxa-moxibustion cream, weight portion meter, mainly it is made up of following material component:
Folium Artemisiae Argyi 80~120 parts and Folium Artemisiae Argyi 2~5.5 parts.
The moxa-moxibustion cream that the present invention provides can individually be incubated in affected part, or coordinates other plaster to be simultaneously used for treating relevant disease,
And with moxa-moxibustion fiting effect more preferably.
Fresh Folium Artemisiae Argyi juice remains the active ingredient of Oleum Folium Artemisiae Argyi, more maintains the toil of Folium Artemisiae Argyi, and more easy entry spleen
Liver and kidney warp.The soft woolliness of Folium Artemisiae Argyi can fully absorb the active ingredient of storage Oleum Folium Artemisiae Argyi, and can make moxa-moxibustion cream Reusability.
Optionally, moxa-moxibustion cream as above, the preparation method of described Folium Artemisiae Argyi is:
Floss cotton like is crumpled into, through patting to journey thin short flannel shape and get final product after being dried by the fresh Folium Artemisiae Argyi eliminating stem.
Optionally, moxa-moxibustion cream as above, by weight, its material component also includes Apis cerana Fabricius 2~3 parts.
Optionally, moxa-moxibustion cream as above, by weight, its material component also include glycerol or vaseline 0.02~
0.06 part.
Optionally, moxa-moxibustion cream as above, by weight, its material component also includes Oleum menthae 0.04~0.15
Part.
The preparation method of moxa-moxibustion cream as above, comprises the following steps:
Fresh Folium Artemisiae Argyi is obtained Folium Artemisiae Argyi concentrated juice and Folium Artemisiae Argyi and other raw materials in addition to Folium Artemisiae Argyi and Folium Artemisiae Argyi through decocting, boiling
Component mixes, after cooling molding and get final product.
Optionally, preparation method as above, when fresh Folium Artemisiae Argyi is decocted, described fresh Folium Artemisiae Argyi and added water
Weight ratio be 1:(1~3).
Optionally, preparation method as above, the weight of described Folium Artemisiae Argyi concentrated juice is described fresh Folium Artemisiae Argyi weight
20%~30%.
The moxa-moxibustion cream as above application in the medicine for external use that preparation treatment arthrosis and cold-evil are caused a disease.
Optionally, applying as above, described arthrosis includes cervical spondylosis, scapulohumeral periarthritis, prolapse of lumbar intervertebral disc;
Described cold-evil is caused a disease and is included cold womb, cold syndrome of the stomach.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but those skilled in the art will
Understanding, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.In embodiment unreceipted specifically
Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument unreceipted production firm person, be
Can be by the commercially available conventional products bought and obtain.
The invention provides a kind of moxa-moxibustion cream and preparation method and application, by weight, described moxa-moxibustion cream mainly by
Following material component is made:
Folium Artemisiae Argyi 80~120 parts and Folium Artemisiae Argyi 2~5.5 parts.
This moxa-moxibustion cream is easy to use, is suitable to be widely popularized use.This moxa-moxibustion cream, as external used medicine, avirulence, is made without secondary
With, will not develop immunity to drugs, abundant raw material source, production cost is low, and need not medical knowledge and the Therapeutic Method of complexity
And can use, can be described as the standing medicine of family, also can solve the situation of outlying district shortage of medical services and medicines.
Preferably, moxa-moxibustion cream as above, the preparation method of described Folium Artemisiae Argyi is:
Floss cotton like is crumpled into, through patting to journey thin short flannel shape and get final product after being dried by the fresh Folium Artemisiae Argyi eliminating stem.
The moxa-moxibustion cream that the present invention provides is melted into pulpous state through smashing post-heating when in use.If plaster hardness
Greatly, adhesion strength little, then be affixed on during skin easy to fall off;Cross tender then stickiness too big, lack flexibility, it is impossible to be fixed on that to stick position easy
Mobile, and be difficult to take off.In moxa-moxibustion cream manufacturing process, due to weather, region and boil the factors such as peopleware, Chinese mugwort
Moxibustion cream is crossed the tenderest problem and is difficult to avoid.
For this problem, the present invention preferably adds Apis cerana Fabricius 2~3 parts in its component.
Apis cerana Fabricius is also known as Cera Flava, and it has natural moistureproof resistance to water, emulsibility and slickness.A certain amount of Apis cerana Fabricius can change
Becoming state the tenderest when moxa-moxibustion cream uses, and alleviate the zest to skin to a certain extent, Apis cerana Fabricius Main Ingredients and Appearance is ester
Class, free acid kind, free-fat alcohols and hydro carbons, sweet in the mouth, light, property is put down;Return spleen, stomach, large intestine channel, have removing toxic substances, granulation promoting,
Dysentery relieving, hemostasis, effect of analgesic therapy.It is possible not only to prevent moxa-moxibustion cream from crossing the tenderest problem occurs, moreover it is possible to effectively reduce fire
Poison, reduces the zest to skin.
Preferably, moxa-moxibustion cream as above, by weight, its material component also include glycerol or vaseline 0.02~
0.06 part.
Glycerol is organic polyhydric alcohol, and vaseline is mineral oil, and both of which has the effect of skin protection.The two is added moxa-moxibustion cream
In, can make to form one protecting film in skin surface when using this product, make the moisture of skin be difficult to evaporation and scatter and disappear, and its pole
Water insoluble, can be attached to for a long time on skin, therefore there is good moistening effect, be very suitable for dry skin and use.
Preferably, moxa-moxibustion cream as above, by weight, its material component also includes Oleum menthae 0.04~0.15
Part.
Oleum menthae is that the fresh stem and leaf of labiate Herba Menthae or family Herba Menthae is through distillable aromatic oil.Pungent, cool, nontoxic.
There is dispelling wind, effect of heat clearing away.Can be used for skin or mucosa produces refrigerant sense and is not suitable for alleviate, main pain.Control affection due to external wind and heat, head
Conjunctival congestion bitterly, pharyngalgia, toothache, skin pruritus due to wind pathogen.Herba Menthae has extremely strong sterilization antibacterial action, therefore coordinates moxa-moxibustion cream to use and can also prolong
Its shelf-life long.
The preparation method of moxa-moxibustion cream as above, comprises the following steps:
Fresh Folium Artemisiae Argyi is obtained Folium Artemisiae Argyi concentrated juice and Folium Artemisiae Argyi and other raw materials in addition to Folium Artemisiae Argyi and Folium Artemisiae Argyi through decocting, boiling
Component mixes, after cooling molding and get final product.
The preparation method of the moxa-moxibustion cream that the present invention provides is simple and easy, and science is easy, it is simple to produce in batch.
Preferably, preparation method as above, when fresh Folium Artemisiae Argyi is decocted, described fresh Folium Artemisiae Argyi and added water
Weight ratio be 1:(1~3).
It is furthermore preferred that the weight ratio stating fresh Folium Artemisiae Argyi and added water is 1:2.
Preferably, preparation method as above, the weight of described Folium Artemisiae Argyi concentrated juice is described fresh Folium Artemisiae Argyi weight
20%~30%.
It is furthermore preferred that the weight of described Folium Artemisiae Argyi concentrated juice is described fresh Folium Artemisiae Argyi weight 23%~27%;More preferably
, it is 25%.
The moxa-moxibustion cream as above application in the medicine for external use that preparation treatment arthrosis and cold-evil are caused a disease.
Preferably, applying as above, described arthrosis includes cervical spondylosis, scapulohumeral periarthritis, prolapse of lumbar intervertebral disc;
Described cold-evil is caused a disease and is included cold womb, cold syndrome of the stomach.
Embodiment 1
Present embodiments providing a kind of moxa-moxibustion cream and preparation method thereof, its material component includes:
Folium Artemisiae Argyi 80g;
Folium Artemisiae Argyi 2g;
Apis cerana Fabricius 3g;
Glycerol 0.02g;
Oleum menthae 0.04g;
Its preparation method is
1, being decocted by fresh Folium Artemisiae Argyi, wherein the ratio of Folium Artemisiae Argyi and water is 1:1, and the temperature of decoction is not done concrete
Limit;
2, the slag after decocting is removed, and collects the juice after decocting, and this juice is brewed in step 1 Folium Artemisiae Argyi weight used
The 20% of amount;Obtain concentrated juice;
3, fresh Folium Artemisiae Argyi is dried, removes its stem, crumple into floss cotton like, repave on flat board, repeatedly pat with long bamboo chip,
Become thin short flannel shape, obtain Folium Artemisiae Argyi;
Described Folium Artemisiae Argyi is added to mix homogeneously in the concentrated juice of gained in step 2, obtains mixed serum.
4, the mixed serum of gained in step 3 adds Apis cerana Fabricius and the mixture of glycerol, be sufficiently mixed;
5, the product of gained in step 4 adds Oleum menthae, be sufficiently mixed;
6, step 5 products obtained therefrom is sufficiently mixed uniformly, cools down aftershaping, make moxa-moxibustion cream.
Embodiment 2
Present embodiments providing a kind of moxa-moxibustion cream and preparation method thereof, its material component includes:
Folium Artemisiae Argyi 120g;
Folium Artemisiae Argyi 5.5g;
Apis cerana Fabricius 2g;
Vaseline 0.06g;
Oleum menthae 0.15g;
Its preparation method is
1, being decocted by fresh Folium Artemisiae Argyi, wherein the ratio of Folium Artemisiae Argyi and water is 1:3, and the temperature of decoction is not done concrete
Limit;
2, the slag after decocting is removed, and collects the juice after decocting, and this juice is brewed in step 1 Folium Artemisiae Argyi weight used
The 30% of amount;Obtain concentrated juice;
3, fresh Folium Artemisiae Argyi is dried, removes its stem, crumple into floss cotton like, repave on flat board, repeatedly pat with long bamboo chip,
Become thin short flannel shape, obtain Folium Artemisiae Argyi;
Described Folium Artemisiae Argyi is added to mix homogeneously in the concentrated juice of gained in step 2, obtains mixed serum.
4, the mixed serum of gained in step 3 adds Apis cerana Fabricius and the mixture of glycerol, be sufficiently mixed;
5, the product of gained in step 4 adds Oleum menthae, be sufficiently mixed;
6, step 5 products obtained therefrom is sufficiently mixed uniformly, cools down aftershaping, make moxa-moxibustion cream.
Embodiment 3
Present embodiments providing a kind of moxa-moxibustion cream and preparation method thereof, its material component includes:
Folium Artemisiae Argyi 100g;
Folium Artemisiae Argyi 4g;
Apis cerana Fabricius 2.5g;
Glycerol 0.04g;
Oleum menthae 0.1g;
Its preparation method is
1, being decocted by fresh Folium Artemisiae Argyi, wherein the ratio of Folium Artemisiae Argyi and water is 1:2, and the temperature of decoction is not done concrete
Limit;
2, the slag after decocting is removed, and collects the juice after decocting, and this juice is brewed in step 1 Folium Artemisiae Argyi weight used
The 25% of amount;Obtain concentrated juice;
3, fresh Folium Artemisiae Argyi is dried, removes its stem, crumple into floss cotton like, repave on flat board, repeatedly pat with long bamboo chip,
Become thin short flannel shape, obtain Folium Artemisiae Argyi;
Described Folium Artemisiae Argyi is added to mix homogeneously in the concentrated juice of gained in step 2, obtains mixed serum.
4, the mixed serum of gained in step 3 adds Apis cerana Fabricius and the mixture of glycerol, be sufficiently mixed;
5, the product of gained in step 4 adds Oleum menthae, be sufficiently mixed;
6, step 5 products obtained therefrom is sufficiently mixed uniformly, cools down aftershaping, make moxa-moxibustion cream.
Experimental example medicine irritation and scratch test
Study subject: 80 healthy volunteers that applicant calls together.
Comparative example 1 is arranged: on the basis of embodiment 3, and its material component is adjusted to Folium Artemisiae Argyi 100g;Folium Artemisiae Argyi 4g;Glycerol
0.04g;Oleum menthae 0.1g.Other conditions are constant.
Comparative example 2: publication number CN101181330A, the Chinese mugwort that in the patent in publication date on May 21st, 2008, embodiment 4 provides
Leaf oil.
Experimental technique: moxa-moxibustion cream is applied in after smashing post-heating and being melted into pulpous state waist, cervical vertebra, extremities joint or
Both shoulders part, observes clinical manifestation and the change of skin situation sticking position after 40 hours.
Judge index: different according to feedback opinion and subject's anaphylactic reaction symptom, is divided into 0~3 grade.
0 grade: without significant reaction;
1 grade:
Have and slightly itch, and duration was less than 1 hour, take off after cream without other table disease phenomenons;
Without itching symptom, but after taking off cream, there are slight red point, blister;
Above-mentioned both have, but phenomenon is slight.
2 grades:
Having the phenomenon that significantly scratches, duration is more than 1 hour or with slight general malaise sense;
There are obvious blister, erythema situation after taking off cream, have phenomenon of itching;
Take off certain interval of time after cream, at plaster or periphery has obvious erythema, phenomenon of itching.
3 grades:
Having the serious phenomenon that scratches, it is itched unbearably or with obvious general malaise sense;
After taking off cream, a period of time skin has Severe erythema, phenomenon of festering.
Statistical methods for experiment
If the statistical method of this test is by the statistical test of optimal efficiency test, its sample size size estimation required is
About 200 examples.But sample size is only 80 examples now, is significantly smaller than the sample size of needs, so it is credible that this method can not be applied to carry out
The item inspections such as degree, standard error, so total allergy rate of only statistical test, as shown in table 1.
Table 1 plaster allergy rate
As it can be seen from table 1 the moxa-moxibustion cream zest that the application provides is weak, allergy rate declines to a great extent, and side effect is dropped significantly
Low.Its reason is probably Apis cerana Fabricius by low molecule catabolite emulsifying so that allergic medicine must not discharge, and reduces the stimulation to skin
Property.
Arthrosis and cold-evil are caused a disease and are had good effect by the moxa-moxibustion cream that the present invention provides, and concrete concrete clinic is such as
Under:
Clinical example 1:
Lee, man, 41 years old age, cardinal symptom: lumbago companion's right lower extremity radiation fiber crops pain, Western medicine diagnose is prolapse of lumbar intervertebral disc
Disease.MRI reports: L5/6 intervertebral disk hernia (to the left), corresponding sections root compression, surrounding soft tissue's edema.Pain sitting adds
Play, lies up and alleviates, the waist warm aversion to cold of happiness etc..Reinstated from 08 04th, 2011 the embodiment of the present invention 3 provide moxa-moxibustion cream:
Use the technology auxiliary treatments such as acupuncture, traditional Chinese massage again.Being almost recovered by the treatment of 2 weeks, MRI check is shown in that root compression subtracts
Gently, surrounding soft tissue's edema disappears.
Clinical example 2:
Song, female, at 32 years old age, cardinal symptom: cold womb continues more than 2 years, irregular menstruation, lower abdomen is cold, with breathing hard
Weak, insomnia and dreamful sleep, hypomenorrhea, premenstrual lower abdomen have falling inflation sense, menstruation darkish complexion to have clot.At umbilicus hits exactly the most lower 1.5 cun
The moxa-moxibustion cream that the application embodiment of the present invention 2 provides, avoids eating anything raw or cold simultaneously, at ordinary times the foods such as Fructus Jujubae, Semen Juglandis, eye meat of eating more, 3 months
It is greatly improved through all after date symptoms, the eumenorrhea, fully recovers after 6 menstrual cycle.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's
May be made that in the case of spirit and scope many other change and amendment.It is, therefore, intended that in the following claims
Including all such changes and modifications belonged in the scope of the invention.
Claims (10)
1. a moxa-moxibustion cream, it is characterised in that by weight, is mainly made up of following material component:
Folium Artemisiae Argyi 80~120 parts and Folium Artemisiae Argyi 2~5.5 parts.
Moxa-moxibustion cream the most according to claim 1, it is characterised in that the preparation method of described Folium Artemisiae Argyi is:
Floss cotton like is crumpled into, through patting to journey thin short flannel shape and get final product after being dried by the fresh Folium Artemisiae Argyi eliminating stem.
Moxa-moxibustion cream the most according to claim 1, it is characterised in that by weight, its material component also include Apis cerana Fabricius 2~
3 parts.
Moxa-moxibustion cream the most according to claim 3, it is characterised in that by weight, its material component also include glycerol or
Vaseline 0.02~0.06 part.
Moxa-moxibustion cream the most according to claim 4, it is characterised in that by weight, its material component also includes Oleum menthae
0.04~0.15 part.
6. the preparation method of the moxa-moxibustion cream described in any one of Claims 1 to 5, it is characterised in that comprise the following steps:
Fresh Folium Artemisiae Argyi is obtained Folium Artemisiae Argyi concentrated juice, with Folium Artemisiae Argyi and other raw material groups in addition to Folium Artemisiae Argyi and Folium Artemisiae Argyi through decocting, boiling
Part mixing, after cooling molding and get final product.
Preparation method the most according to claim 6, it is characterised in that when fresh Folium Artemisiae Argyi is decocted, described fresh Chinese mugwort
Leaf is 1:(1~3 with the weight ratio of added water).
Preparation method the most according to claim 6, it is characterised in that the weight of described Folium Artemisiae Argyi concentrated juice is described fresh
The 20%~30% of Folium Artemisiae Argyi weight.
9. the answering in the medicine for external use that preparation treatment arthrosis and cold-evil are caused a disease of the moxa-moxibustion cream described in any one of Claims 1 to 5
With.
Application the most according to claim 9, it is characterised in that described arthrosis includes cervical spondylosis, scapulohumeral periarthritis, lumbar intervertebral disc
Prominent;
Described cold-evil is caused a disease and is included cold womb, cold syndrome of the stomach.
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CN113925774B (en) * | 2021-11-12 | 2024-01-05 | 吴学刚 | Preparation method of Chinese herbal medicine |
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