CN106214571B - Melia azedarach mosquito-repellent composition and preparation method and application thereof - Google Patents

Melia azedarach mosquito-repellent composition and preparation method and application thereof Download PDF

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CN106214571B
CN106214571B CN201610763399.8A CN201610763399A CN106214571B CN 106214571 B CN106214571 B CN 106214571B CN 201610763399 A CN201610763399 A CN 201610763399A CN 106214571 B CN106214571 B CN 106214571B
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钟林邑
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Abstract

The invention relates to the field of mosquito preparations, in particular to a chinaberry mosquito-repellent composition and a preparation method and application thereof. The chinaberry mosquito-repellent composition comprises the following components in parts by mass: 20-60 parts of chinaberry, 20-50 parts of aquilaria sinensis, 20-50 parts of rosewood, 1-30 parts of Pandanus communis leaves, 1-30 parts of Ailanthus altissima, 1-10 parts of mimosa pudica, 1-10 parts of dandelion and 0.5-5 parts of borneol. Through the compatibility of the components, the mosquito-repellent composition disclosed by the invention has unique smell, can effectively remove mosquitoes, and has good effects of stopping scars, relieving itching, reducing swelling, relieving pain and resisting allergy on the symptoms such as bag and itching caused by mosquito bites. The preparation method provided by the invention can effectively protect volatile components in the product from being damaged, and has the advantages of simple preparation process and easy operation. The obtained composition can be used for preparing various mosquito repellent preparations.

Description

Melia azedarach mosquito-repellent composition and preparation method and application thereof
Technical Field
The invention relates to the field of mosquito preparations, in particular to a chinaberry mosquito-repellent composition and a preparation method and application thereof.
Background
With the coming of summer, mosquitoes start to move, and after biting, the mosquitoes bring various discomforts such as itching, red swelling and the like to the skin, are easy to infect diseases and influence the normal life of people. After the mosquito bites, saliva or venom of the mosquito invades the skin, and the saliva or venom of the mosquito contains a plurality of antigen components, so that the antigens can generate allergic reaction with antibodies to cause inflammation after entering the skin of a human body. In severe cases, severe reactions such as bullous blisters and hemorrhagic necrosis occur locally in individual patients, which is a common disease in dermatology in summer. In tropical rain forest regions in Hainan, the annual average temperature is above 20 ℃, the mosquito activity time is long, the quantity is large, the types are various, and the mosquito repellent is one of the stock. Most of the existing mosquito repellent preparations contain chemical components, and are easy to cause harm to human bodies, especially infants and sensitive physique.
Melia azedarach (Melia azedarach) is a famous variety of Meliaceae plants, and its bark, root bark, leaves, fruits and flowers can be used as medicine, and has remarkable therapeutic effect. However, the cortex Meliae, folium Meliae and fructus Toosendan have different degrees of toxicity, and have good therapeutic effect when combined clinically.
Disclosure of Invention
The invention provides a chinaberry mosquito-repellent composition and a preparation method and a preparation thereof, wherein chinaberry is used as a main component, and the chinaberry mosquito-repellent composition has the effects of repelling mosquitoes, preventing bites, relieving itching, reducing swelling and relieving pain through compatibility.
The technical scheme of the invention is realized as follows:
a chinaberry mosquito repellent composition comprises the following components in parts by mass: 20-60 parts of chinaberry, 20-50 parts of aquilaria sinensis, 20-50 parts of rosewood, 1-30 parts of Pandanus communis leaves, 1-30 parts of Ailanthus altissima, 1-10 parts of mimosa pudica, 1-10 parts of dandelion and 0.5-5 parts of borneol.
Further, the chinaberry mosquito-repellent composition comprises the following components in parts by mass: 30-50 parts of chinaberry, 30-40 parts of aquilaria sinensis, 30-40 parts of rosewood, 10-20 parts of Pandanus communis leaves, 10-20 parts of Ailanthus altissima, 2-8 parts of mimosa pudica, 2-8 parts of dandelion and 1-3 parts of borneol.
Furthermore, the melia azedarach is melia azedarach skin or melia azedarach leaves.
A preparation method of a chinaberry mosquito-repellent combination comprises the following steps:
weighing chinaberry, aquilaria sinensis, rosewood, Chinese pandan leaf, hedyotis herb, mimosa pudica and dandelion according to the formula ratio, adding ethanol for extraction for 3 times, controlling the temperature to be 10-40 ℃ in the ethanol extraction process, merging the extracting solutions for 3 times, filtering to remove residues, drying, adding borneol, and uniformly mixing to obtain the chinaberry mosquito-repellent composition.
Further, the volume concentration of the ethanol is 70-85%; the adding amount of the ethanol is 5-10 times of the total amount of the medicinal materials, and the extraction mode is soaking extraction or ultrasonic extraction; the drying method is vacuum drying or freeze drying.
The chinaberry mosquito-repellent composition is applied to preparing mosquito-repellent preparations.
11. A melia azedarach mosquito repellent preparation is characterized in that: comprising the mosquito repellent composition of any one of claims 1-6.
Further, the mosquito repellent preparation is solid or liquid.
A liquid mosquito-repellent preparation is prepared by the following steps:
dissolving the obtained Melia azedarach mosquito repellent composition in 10-30 times of ethanol, filtering to remove insoluble substances, and sterilizing.
A solid mosquito-repellent preparation is characterized in that the preparation method comprises the following steps:
pulverizing the above Melia azedarach mosquito repellent composition, adding adjuvants, mixing, and press forming.
The invention has the beneficial effects that:
the chinaberry mosquito-repellent composition disclosed by the invention selects common chinaberry, common aquilaria sinensis and common rosewood in tropical areas as main raw materials, and is added with common Pandanus communis leaves, Ailanthus altissima, mimosa pudica, dandelion and borneol, and has unique smell through formula compatibility, can effectively remove mosquitoes, and has good effects of trace stopping, itching relieving, swelling and pain relieving for symptoms such as bag forming and itching caused by mosquito bites. The preparation method provided by the invention has the advantages that the ethanol is adopted to extract the effective components in the medicinal materials, the temperature is controlled to be lower in the extraction process, the volatile components in the medicinal materials can be effectively protected from being damaged, the preparation process is simple, and the operation is easy.
The melia azedarach is bitter in taste and cold in nature, and has the effects of killing insects and treating tinea; the aquilaria sinensis has delicate and lasting fragrance and has the effects of promoting qi circulation, warming middle-jiao and relieving asthma; the rosewood has the effects of promoting qi circulation and activating blood circulation, and has unique curative effect on skin allergy. The Pandanus communis leaves have unique rice dumpling fragrance, and squalene contained in the leaves has the functions of permeation, diffusion and sterilization, and can enhance cell activity and immunity; the pterocarpus has mild pungent and warm properties, has the effects of removing blood stasis, relieving swelling, detoxifying and stopping bleeding, and has better curative effects on traumatic swelling and pain, pyocutaneous disease, pyogenic infections and the like. The mimosa pudica has the effects of clearing heat, promoting urination, soothing the nerves, relieving pain, removing toxicity, dissipating blood stasis, stopping bleeding, astringing and the like, and has better curative effects on traumatic injury, sore and ulcer pyogenic infections and the like. The dandelion has the functions of dissipating stagnation and reducing swelling, accelerating blood circulation and promoting the disappearance of lumps, and has more obvious effects of detoxifying, reducing swelling and relieving itching. The borneol mainly contains d-borneol, has faint scent and certain mosquito and insect repelling effect.
The medicinal materials are compatible through the formula, the medicinal properties are mutually influenced, the toxicity of the melia azedarach can be effectively neutralized, and the harm of the toxicity of the melia azedarach to a human body is eliminated. The aquilaria sinensis and the Pandanthus urinaria leaves in the formula have unique fragrance, and are blended and coexisted with the taste of other components in the formula to form unique smell, so that a good mosquito and insect repelling effect can be achieved. Meanwhile, the traditional Chinese medicine composition has good effects of detoxifying, relieving swelling, relieving itching and preventing and treating skin allergy. In addition, as the borneol has good volatility, effective components in the formula can be volatilized into the air, and the mosquito-repellent effect of the traditional Chinese medicine in the formula is more obvious. The borneol is easy to be absorbed through skin; the effective components in the Pandanus communis Hance have good penetration effect, have good promotion effect on the absorption of other medicinal materials in the formula, can better exert the effects of detoxifying, detumescence and itching relieving in the formula, and achieve the purpose of quickly relieving itching and detumescence.
Detailed Description
The technical solutions in the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A chinaberry mosquito repellent composition comprises the following components in parts by mass: 20g of chinaberry bark, 20g of aquilaria sinensis, 20g of rosewood, 1g of Pandanus communis leaf, 1g of comfrey, 1g of mimosa pudica, 1g of dandelion and 0.5g of borneol.
A preparation method of a chinaberry mosquito-repellent combination comprises the following steps:
weighing chinaberry bark, rosewood, aquilaria sinensis, panduraceae leaves, pterocarpus marsupium, mimosa pudica and dandelion according to the formula, adding ethanol with the volume concentration of 70%, soaking and extracting for 3 times, wherein the adding amount of the ethanol is 5 times of the total amount of the medicinal materials; controlling the temperature to be 10 ℃ in the ethanol extraction process, merging the extracting solutions for 3 times, filtering to remove residues, drying the filtrate in vacuum, adding borneol, and uniformly mixing to obtain the melia azedarach mosquito-repellent composition.
The composition can be added with corresponding adjuvants for preparing various mosquito repellent preparations.
Example 2
A chinaberry mosquito repellent composition comprises the following components in parts by mass: 60g of chinaberry leaves, 50g of aquilaria sinensis, 50g of roses, 30g of Pandanus communis leaves, 30g of aeroplane herb, 10g of sensitive plants, 10g of dandelion and 5g of borneol.
A preparation method of a chinaberry mosquito-repellent combination comprises the following steps:
weighing chinaberry leaves, aquilaria sinensis, rosewood, pandanus leaves, pterocarpus marsupium, mimosa pudica and dandelion according to the formula, adding ethanol with the volume concentration of 85% for soaking/ultrasonic extraction for 3 times, wherein the adding amount of the ethanol is 10 times of the total amount of the medicinal materials; controlling the temperature at 40 ℃ in the ethanol extraction process, merging the extracting solutions for 3 times, filtering to remove residues, freeze-drying the filtrate, adding borneol, and uniformly mixing to obtain the melia azedarach mosquito-repellent composition.
The composition can be added with corresponding adjuvants for preparing various preparations for repelling mosquito.
Example 3
A chinaberry mosquito repellent composition comprises the following components in parts by mass: the traditional Chinese medicine composition comprises 40g of chinaberry leaf, 35g of aquilaria sinensis, 35g of rosewood, 15g of Pandanus communis leaf, 15g of aircraft grass, 5g of sensitive plant, 5g of dandelion and 2g of borneol.
A preparation method of a chinaberry mosquito-repellent combination comprises the following steps:
weighing chinaberry leaves, aquilaria sinensis, rosewood, pandanus leaves, pterocarpus marsupium, mimosa pudica and dandelion according to the formula, adding ethanol with the volume concentration of 70-85% for soaking/ultrasonic extraction for 3 times, wherein the adding amount of the ethanol is 8 times of the total amount of the medicinal materials; controlling the temperature at 20 ℃ in the ethanol extraction process, merging the extracting solutions for 3 times, filtering to remove residues, drying the filtrate in vacuum, adding borneol, and uniformly mixing to obtain the melia azedarach mosquito-repellent composition.
The composition can be added with corresponding adjuvants for preparing various mosquito repellent preparations.
Example 4
A chinaberry mosquito repellent composition comprises the following components in parts by mass: 30g of chinaberry bark, 30g of aquilaria sinensis, 30g of rosewood, 10g of Pandanus communis leaves, 10g of aeroplane herb, 2g of sensitive plant, 2g of dandelion and 1g of borneol.
A preparation method of a chinaberry mosquito-repellent combination comprises the following steps:
weighing cortex Meliae, radix Aristolochice, fructus Pyri, herba Pandani Palmatae leaf, herba Ainsliaeae Rubrinervis, herba Mimosae Pudicae, and herba Taraxaci according to formula, adding 75% ethanol, and ultrasonic extracting for 3 times, wherein the amount of ethanol is 6 times of the total amount of the medicinal materials; controlling the temperature at 30 ℃ in the ethanol extraction process, merging the extracting solutions for 3 times, filtering to remove residues, freeze-drying the filtrate, adding borneol, and uniformly mixing to obtain the melia azedarach mosquito-repellent composition.
The composition can be added with corresponding adjuvants for preparing various preparations for repelling mosquito.
Example 5
A chinaberry mosquito repellent composition comprises the following components in parts by mass: 50g of chinaberry bark, 40g of aquilaria sinensis, 40g of rosewood, 20g of Pandanus communis leaves, 20g of Ailanthus altissima, 8g of sensitive plants, 8g of dandelion and 3g of borneol.
A preparation method of a chinaberry mosquito-repellent combination comprises the following steps:
weighing cortex Meliae, radix Aristolochice, fructus Pyri, herba Pandani Palmatae leaf, herba Ainsliaeae Rubrinervis, herba Mimosae Pudicae, and herba Taraxaci according to formula, soaking in 80% ethanol for 3 times, wherein the amount of ethanol is 10 times of the total amount of the medicinal materials; controlling the temperature to be 10 ℃ in the ethanol extraction process, merging the extracting solutions for 3 times, filtering to remove residues, freeze-drying, adding borneol, and uniformly mixing to obtain the melia azedarach mosquito-repellent composition.
The composition can be added with corresponding adjuvants for preparing various mosquito repellent preparations.
Example 6
A liquid mosquito repellent preparation is prepared by the following steps:
dissolving the obtained Melia azedarach mosquito repellent composition in 10-30 times of ethanol, filtering to remove insoluble substances, and sterilizing.
The liquid mosquito-repellent preparation prepared by the embodiment can be prepared into various dosage forms such as spray, external liniment and the like according to requirements, and is directly sprayed on the surface of air or skin, clothes and the like to play a role in preventing mosquito bites. Can also be applied to affected part after mosquito bite to relieve itching, remove toxic substance, and relieve swelling.
Example 7
A solid mosquito-repellent preparation is characterized in that the preparation method comprises the following steps:
pulverizing the above Melia azedarach mosquito repellent composition, adding charcoal powder and starch, wherein the charcoal powder is 20-30 times of the total weight of the composition, and the starch is 5-10 times of the total weight of the composition; mixing, adding water to obtain viscous paste, press forming, and drying.
The solid mosquito repellent can be directly made into common mosquito repellent incense and can be directly ignited for use. The mosquito repellent incense can also be made into an electric mosquito repellent incense sheet, and the gas volatilized by the mosquito repellent incense sheet plays a role in repelling mosquitoes.
The melia azedarach mosquito-repellent composition has the application effect
The mosquito repellent compositions prepared in the embodiments 1 to 5 are respectively prepared into mosquito repellent preparations according to the methods of the embodiments 6 or 7, 30 persons are randomly selected in different places and are randomly divided into 6 groups, and 5 persons in each group. Wherein 5 groups are used as experimental groups, and different mosquito repellent preparations are prepared by respectively using the mixture ratio of the embodiments 1-5 of the invention; group 6 used Liushen toilet water as a control group. The spraying agent, the mosquito-repellent incense or the electric mosquito-repellent incense tablet prepared by the invention has the advantages that the mosquitoes are not close to each other, and the situation of mosquito biting is obviously reduced or completely eliminated after the spraying agent, the mosquito-repellent incense or the electric mosquito-repellent incense tablet are used. Has the mosquito repelling effect equivalent to that of the common Liushen toilet water and has obvious mosquito repelling effect.
After the mosquito repellent water is smeared on the surface of skin bitten by mosquitoes, the mosquito repellent water has faint scent, can generate unique cool feeling, can quickly eliminate symptoms such as red swelling, itching, allergy and the like, and has obvious effects of detumescence, itching relieving, antibiosis, antiphlogosis, detoxification and antianaphylaxis. Especially for anaphylactic reaction caused by mosquito bite, the mosquito-repellent preparation has obvious effect.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (4)

1. A solid mosquito repellent preparation is common mosquito repellent incense or electric mosquito repellent incense tablet, and is characterized in that the preparation method comprises the following steps:
pulverizing cortex Meliae composition for repelling mosquito, adding charcoal powder and starch, mixing, adding water to obtain viscous paste, press forming, and drying; the addition amount of the charcoal powder is 20-30 times of the total mass of the chinaberry mosquito-repellent composition, and the addition amount of the starch is 5-10 times of the total mass of the chinaberry mosquito-repellent composition; the chinaberry mosquito-repellent composition comprises the following components in parts by mass: 20-60 parts of chinaberry, 20-50 parts of aquilaria sinensis, 20-50 parts of rosewood, 1-30 parts of pandanus, 1-30 parts of aeroplane, 1-10 parts of mimosa pudica, 1-10 parts of dandelion and 0.5-5 parts of borneol; the preparation method of the chinaberry mosquito-repellent composition comprises the following steps:
weighing chinaberry, aquilaria sinensis, rosewood, panduraceae leaves, pterocarpus marsupium, mimosa pudica and dandelion according to the formula ratio, adding ethanol for extraction for 3 times, controlling the temperature to be 10-40 ℃ in the ethanol extraction process, combining the extracting solutions for 3 times, filtering to remove residues, drying, adding borneol and mixing uniformly to obtain the traditional Chinese medicine.
2. The solid mosquito-repellent preparation according to claim 1, wherein the chinaberry mosquito-repellent composition comprises the following components in parts by weight: 30-50 parts of chinaberry, 30-40 parts of aquilaria sinensis, 30-40 parts of rosewood, 10-20 parts of Pandanus communis leaves, 10-20 parts of Ailanthus altissima, 2-8 parts of mimosa pudica, 2-8 parts of dandelion and 1-3 parts of borneol.
3. A solid mosquito repellent formulation according to claim 1, wherein: the cortex Meliae is cortex Meliae or folium Meliae.
4. A solid mosquito repellent formulation according to claim 1, wherein: the volume concentration of the ethanol is 70-85%; the adding amount of the ethanol is 5-10 times of the total amount of the medicinal materials, and the extraction mode is soaking extraction or ultrasonic extraction; the drying method is vacuum drying or freeze drying.
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CN109303077A (en) * 2018-09-30 2019-02-05 湖州稻草娃生物科技有限公司 A kind of pest repellant
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