CN106177188A - A kind of probiotic composition for the antibacterial balance of women and preparation method thereof - Google Patents
A kind of probiotic composition for the antibacterial balance of women and preparation method thereof Download PDFInfo
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- CN106177188A CN106177188A CN201610623062.7A CN201610623062A CN106177188A CN 106177188 A CN106177188 A CN 106177188A CN 201610623062 A CN201610623062 A CN 201610623062A CN 106177188 A CN106177188 A CN 106177188A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/733—Fructosans, e.g. inulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- Biotechnology (AREA)
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- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of probiotic composition for the antibacterial balance of women and preparation method thereof.The composition of described compositions includes: Folium Nelumbinis extract, Folium Camelliae sinensis extract, Fructus psidii guajavae immaturus extract, lactobacillus rhamnosus, alpha-glucan oligosaccharide, oligofructose, oligomeric xylose, inulin, arabic gum, polydextrose chitosan.The probiotic composition of the antibacterial balance of women of the present invention uses the allotment of multiple natural plant extracts to form, have no drug resistance, do not affect the profitable strains such as Vaginal lactobacilli, can effectively safeguard the normal microecological environment of intravaginal, effectively alleviate the gynecological inflammation that women is common, such as trichomonal vaginitis, colpitis mycotica and chronic cervicitis etc., reduce female reproductive system and infect；Additionally, this compositions can nourishing YIN and benefiting blood, women can be alleviated and decline the symptoms such as the vaginal dryness, dyspareunia and the hyposexuality that cause due to ovarian function.Drug effect is gentle, evident in efficacy, have no side effect.
Description
Technical field
The present invention relates to a kind of probiotic composition for the antibacterial balance of women and preparation method thereof.
Background technology
The vaginal mucosa of women is the most sensitive to stimulation or inflammation.Susceptible women such as contact swimming pool or other
After water body or sexual intercourse, it is possible to the inflammatory reaction in vaginal mucosa district can be caused.Hormone change, such as, take contraceptive, gestation
Phase, age of sucking or in menopause, it is also possible to cause the irritant reaction of vaginal mucosa.Vaginal mucosa irritation not only pain, and
Further inflammation may be developed into, the normal function of other organs of women can be affected.It practice, there are tens women quilts every year
This stimulation infects, and causes the happiness of women to decline.
Preliminary study, vaginal mucosa irritation or inflammation cause due to disturbed vaginal flora.Therefore, should during women is daily
Strengthen the nursing of vagina, maintain the in a healthy and balanced way of intravaginal environment.
Summary of the invention
It is an object of the invention to provide a kind of probiotic composition for the antibacterial balance of women and preparation method thereof
The technical solution used in the present invention is:
A kind of probiotic composition for the antibacterial balance of women, its composition includes: Folium Nelumbinis extract, Folium Camelliae sinensis extract, kind stone
Pomegranate berry extract, lactobacillus rhamnosus, alpha-glucans oligosaccharide, oligofructose, oligomeric xylose, inulin, arabic gum, polydextrose
Chitosan.
As preferably, the described composition for the probiotic composition of the antibacterial balance of women includes: Folium Nelumbinis extract 2-8
Part, Folium Camelliae sinensis extract 1-5 part, Fructus psidii guajavae immaturus extract 2-4 part, lactobacillus rhamnosus 1-3 part, alpha-glucans oligosaccharide 5-10 part,
Oligofructose 5-10 part, oligomeric xylose 6-12 part, inulin 1-5 part, arabic gum 4-8 part, polydextrose chitosan 5-
10 parts.
It is further preferred that the described composition for the probiotic composition of the antibacterial balance of women includes: Folium Nelumbinis extract 5
Part, Folium Camelliae sinensis extract 2 parts, Fructus psidii guajavae immaturus extract 3 parts, lactobacillus rhamnosus 2 parts, alpha-glucans oligosaccharide 5 parts, oligofructose 10
Part, oligomeric xylose 10 parts, inulin 5 parts, arabic gum 6 parts, polydextrose chitosan 10 parts.
The above-described probiotic composition for the antibacterial balance of women is prepared as external preparation, including walking as follows
Rapid:
(1) each raw material is weighed by formula；
(2) in reactor, Folium Nelumbinis extract, Folium Camelliae sinensis extract, Fructus psidii guajavae immaturus extract, alpha-glucans oligosaccharide, oligomeric fruit are added
Sugar, oligomeric xylose, inulin, arabic gum, polydextrose chitosan and water, 85 DEG C of stirrings 30～60min, obtain breast
Liquid；
(3) step (2) emulsion adds lactobacillus rhamnosus, stirs, after pasteurization, and fill.
The invention has the beneficial effects as follows: the probiotic composition of the antibacterial balance of women of the present invention uses multiple natural plants
Extract allotment forms, and has no drug resistance, does not affect the profitable strains such as Vaginal lactobacilli, can effectively safeguard the normal micro-life of intravaginal
State environment, effectively alleviates the gynecological inflammation that women is common, such as trichomonal vaginitis, colpitis mycotica and chronic cervicitis etc.,
Reduce female reproductive system to infect；Additionally, this compositions can nourishing YIN and benefiting blood, can alleviate women due to ovarian function decline cause
The symptom such as vaginal dryness, dyspareunia and hyposexuality.Drug effect is gentle, evident in efficacy, have no side effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further detailed explanation, but does not constitute any limitation of the invention.
The change of anyone limited number of time made within the scope of the invention as claimed, still at the claims of the present invention
In.Raw material used in embodiment is commercial goods.
Embodiment 1
A kind of probiotic composition for the antibacterial balance of women, its composition includes: Folium Nelumbinis extract 2 parts, Folium Camelliae sinensis extract 5
Part, Fructus psidii guajavae immaturus extract 4 parts, lactobacillus rhamnosus 1 part, alpha-glucans oligosaccharide 10 parts, oligofructose 5 parts, oligomeric xylose 12
Part, inulin 1 part, arabic gum 4 parts, polydextrose chitosan 5 parts, 100 parts of water.
Embodiment 2
A kind of probiotic composition for the antibacterial balance of women, its composition includes: Folium Nelumbinis extract 5 parts, Folium Camelliae sinensis extract 2
Part, Fructus psidii guajavae immaturus extract 3 parts, lactobacillus rhamnosus 2 parts, alpha-glucans oligosaccharide 5 parts, oligofructose 10 parts, oligomeric xylose 10
Part, inulin 5 parts, arabic gum 6 parts, polydextrose chitosan 10 parts, 150 parts of water.
Embodiment 3
A kind of probiotic composition for the antibacterial balance of women, its composition includes: Folium Nelumbinis extract 8 parts, Folium Camelliae sinensis extract 3
Part, Fructus psidii guajavae immaturus extract 2 parts, lactobacillus rhamnosus 3 parts, alpha-glucans oligosaccharide 8 parts, oligofructose 8 parts, oligomeric xylose 6 parts,
Inulin 3 parts, arabic gum 8 parts, polydextrose chitosan 8 parts, 200 parts of water.
Embodiment 4
The probiotic composition being used for the antibacterial balance of women described in any one of embodiment 1-3 is prepared as external preparation, including
Following steps:
(1) each raw material is weighed by formula；
(2) in reactor, Folium Nelumbinis extract, Folium Camelliae sinensis extract, Fructus psidii guajavae immaturus extract, alpha-glucans oligosaccharide, oligomeric fruit are added
Sugar, oligomeric xylose, inulin, arabic gum, polydextrose chitosan and water, 85 DEG C of stirrings 30～60min, obtain breast
Liquid；
(3) step (2) emulsion adds lactobacillus rhamnosus, stirs, after pasteurization, and fill.
The invention has the beneficial effects as follows: the compositions of the vaginal care balance therapy of the present invention uses multiple natural plants to carry
Take thing allotment to form, have no drug resistance, do not affect the profitable strains such as Vaginal lactobacilli, can effectively safeguard the normal Tiny ecosystem of intravaginal
Environment, effectively alleviates the gynecological inflammation that women is common, such as trichomonal vaginitis, colpitis mycotica and chronic cervicitis etc., subtracts
Maiden's sexual reproduction system infections；Additionally, this compositions can nourishing YIN and benefiting blood, women can be alleviated and cause owing to ovarian function declines
The symptoms such as vaginal dryness, dyspareunia and hyposexuality.Drug effect is gentle, evident in efficacy, have no side effect.
Clinic Case:
Certain patient female 38 years old, pruritus vulvae, leucorrhea amount is many, has abnormal flavour, is defined as bacterial vaginitis after diagnosing.Use and implement
Once, after using two weeks continuously, pruritus substantially alleviates the lotion of example 2 foam washing external genital sooner or later, again checks again after one week,
Recovery from illness.
Certain patient female 33 years old, pruritus vulvae, burning sensation 10 days, many with leucorrhea amount, there is abnormal flavour.Within 12nd day, go to a doctor and have a medical check-up,
The a large amount of thin foam of intravaginal, leucorrhea yellow green, take leucorrhea picture check leukocyte (+++), candidiasis (+), infusorian (-).Make
With the lotion of embodiment 2 foam washing external genital sooner or later once, after using two weeks continuously, pruritus substantially alleviates, again with after two weeks again
Check, recovery from illness.
Certain patient female 28 years old, often pruritus vulvae, vagina is scorching hot, frequent micturition, urgent micturition, and lower part of the body falling inflation is diagnosed as through doctor
Bacterial vaginosis, uses the water preparation foam washing external genital sooner or later of embodiment 1 once, and after using one week continuously, pruritus substantially subtracts
Gently, again checked after three weeks again, recovery from illness.
Claims (4)
1., for the probiotic composition of the antibacterial balance of women, its composition includes: Folium Nelumbinis extract, Folium Camelliae sinensis extract, kind
Punica granatum L. extract, lactobacillus rhamnosus, alpha-glucans oligosaccharide, oligofructose, oligomeric xylose, inulin, arabic gum, poly-Fructus Vitis viniferae
Sugar chitosan.
Probiotic composition for the antibacterial balance of women the most according to claim 1, it is characterised in that it forms bag
Include: Folium Nelumbinis extract 2-8 part, Folium Camelliae sinensis extract 1-5 part, Fructus psidii guajavae immaturus extract 2-4 part, lactobacillus rhamnosus 1-3 part, α-Portugal
Chitosan oligosaccharide 5-10 part, oligofructose 5-10 part, oligomeric xylose 6-12 part, inulin 1-5 part, arabic gum 4-8 part, polydextrose
Chitosan 5-10 part.
Probiotic composition for the antibacterial balance of women the most according to claim 2, it is characterised in that it forms bag
Include: Folium Nelumbinis extract 5 parts, Folium Camelliae sinensis extract 2 parts, Fructus psidii guajavae immaturus extract 3 parts, lactobacillus rhamnosus 2 parts, alpha-glucans oligosaccharide
5 parts, oligofructose 10 parts, oligomeric xylose 10 parts, inulin 5 parts, arabic gum 6 parts, polydextrose chitosan 10 parts.
4. the probiotic composition being used for the antibacterial balance of women described in any one of claim 1-3 is prepared as external preparation,
Comprise the steps:
(1) each raw material is weighed by formula；
(2) in reactor, Folium Nelumbinis extract, Folium Camelliae sinensis extract, Fructus psidii guajavae immaturus extract, alpha-glucans oligosaccharide, oligomeric fruit are added
Sugar, oligomeric xylose, inulin, arabic gum, polydextrose chitosan and water, 85 DEG C of stirrings 30～60min, obtain breast
Liquid；
(3) step (2) emulsion adds lactobacillus rhamnosus, stirs, after pasteurization, and fill.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610623062.7A CN106177188A (en) | 2016-08-02 | 2016-08-02 | A kind of probiotic composition for the antibacterial balance of women and preparation method thereof |
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| CN201610623062.7A CN106177188A (en) | 2016-08-02 | 2016-08-02 | A kind of probiotic composition for the antibacterial balance of women and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107243017A (en) * | 2017-06-09 | 2017-10-13 | 成都珂萝瑞诗化妆品有限公司 | A kind of antibacterial balance gynecological gel and preparation method thereof |
| CN107998154A (en) * | 2017-12-14 | 2018-05-08 | 广州普维君健药业有限公司 | Probiotics preparation for preventing women's diseases and its preparation method and application |
| CN108338993A (en) * | 2018-02-02 | 2018-07-31 | 云南中京国建投资有限公司 | A kind of symphysis unit composition of conditioning female reproductive health and its preparation and application |
| JP2020132621A (en) * | 2019-02-19 | 2020-08-31 | 森永乳業株式会社 | Composition for skin gas emission control |
| CN112089827A (en) * | 2020-10-30 | 2020-12-18 | 湖南婕妙生物科技有限公司 | Prebiotic-containing pharmaceutical composition for regulating female vaginal microecological balance, preparation and use thereof |
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| CN101031313A (en) * | 2004-11-16 | 2007-09-05 | 安尼德拉尔有限公司 | Probiotic bacteria based composition and use thereof in the prevention and/or treatment of respiratory pathologies and/or infections and in the improvement of the intestinal functionality |
| CN104435366A (en) * | 2014-10-30 | 2015-03-25 | 徐澄飞 | Composition containing herbal extract and makeup material composition |
| CN105434605A (en) * | 2015-06-03 | 2016-03-30 | 马南行 | Composition for vaginal nursing balancing therapy and preparation method thereof |
-
2016
- 2016-08-02 CN CN201610623062.7A patent/CN106177188A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101031313A (en) * | 2004-11-16 | 2007-09-05 | 安尼德拉尔有限公司 | Probiotic bacteria based composition and use thereof in the prevention and/or treatment of respiratory pathologies and/or infections and in the improvement of the intestinal functionality |
| CN104435366A (en) * | 2014-10-30 | 2015-03-25 | 徐澄飞 | Composition containing herbal extract and makeup material composition |
| CN105434605A (en) * | 2015-06-03 | 2016-03-30 | 马南行 | Composition for vaginal nursing balancing therapy and preparation method thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107243017A (en) * | 2017-06-09 | 2017-10-13 | 成都珂萝瑞诗化妆品有限公司 | A kind of antibacterial balance gynecological gel and preparation method thereof |
| CN107998154A (en) * | 2017-12-14 | 2018-05-08 | 广州普维君健药业有限公司 | Probiotics preparation for preventing women's diseases and its preparation method and application |
| CN107998154B (en) * | 2017-12-14 | 2020-10-23 | 广州普维君健药业有限公司 | Probiotics preparation for preventing and treating female diseases and preparation method and application thereof |
| CN108338993A (en) * | 2018-02-02 | 2018-07-31 | 云南中京国建投资有限公司 | A kind of symphysis unit composition of conditioning female reproductive health and its preparation and application |
| JP2020132621A (en) * | 2019-02-19 | 2020-08-31 | 森永乳業株式会社 | Composition for skin gas emission control |
| JP7373918B2 (en) | 2019-02-19 | 2023-11-06 | 森永乳業株式会社 | Composition for regulating skin gas diffusion |
| CN112089827A (en) * | 2020-10-30 | 2020-12-18 | 湖南婕妙生物科技有限公司 | Prebiotic-containing pharmaceutical composition for regulating female vaginal microecological balance, preparation and use thereof |
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