CN106176572A - A kind of microneedle array plaster and preparation method thereof - Google Patents
A kind of microneedle array plaster and preparation method thereof Download PDFInfo
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- CN106176572A CN106176572A CN201610694722.0A CN201610694722A CN106176572A CN 106176572 A CN106176572 A CN 106176572A CN 201610694722 A CN201610694722 A CN 201610694722A CN 106176572 A CN106176572 A CN 106176572A
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- microneedle array
- layer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The open a kind of microneedle array plaster of the present invention, includes adhered layer, microneedle array layer and elastic drug-loaded layer the most successively；Described microneedle array layer includes that microneedle array substrate and microneedle array, described microneedle array are located at the upper surface of described microneedle array substrate, and the lower surface of described microneedle array substrate is fixed on described adhered layer；Described microneedle array inserts described elastic drug-loaded layer from the lower surface of described elastic drug-loaded layer, and the top of described microneedle array does not penetrates the upper surface of described elastic drug-loaded layer；Described elastic drug-loaded layer comprises elastomeric material and the medicine being distributed in described elastomeric material.Microneedle array plaster of the present invention by coating, puncture and transmit three during integrated, be effectively simplified micropin be administered step.Meanwhile, the invention also discloses the preparation method of described microneedle array plaster.
Description
Technical field
The present invention relates to a kind of plaster and preparation method thereof, a kind of microneedle array by painless percutaneous dosing
Plaster and preparation method thereof.
Background technology
Traditional administering mode mainly has oral administration, drug administration by injection, sublingual administration, rectally and spraying suction etc.,
These administering modes are respectively present more defect, as follows:
Although oral administration is safe and simple, convenient and easy and expense is relatively low, but medicine is easily by other drug and food
Impact, and make the inefficiency of medicine, it is impossible to reach pharmaceutically-active maximization, and digestive tract can be caused one by some drugs
Fixed infringement；Although drug administration by injection avoids the curative effect shortcoming of oral drugs, but can bring more misery, treatment effect to patient
Fruit also can be deteriorated；The administering modes such as sublingual administration, rectally and spraying suction are then only used for indivedual several drugs, it is impossible to full
The current demand being administered of foot.Additionally, above-mentioned convenient administration mode there is also the problem that cannot be diluted completely by medicine.
At present, emerging administering mode mainly has transdermal administration and micropin to be administered.Transdermal administration is by Liniment form
Medicine is affixed on skin surface, utilize the infiltration of skin to carry out medicine transmission, but due to the obstruction of skin, the transmission effect of medicine
Rate is low, speed is slow；And micropin is administered as Wicresoft's means of a kind of relative efficiency, had that efficiency is high, it is low to damage concurrently, can slow release,
Speed waits four big advantages soon.
And microneedle cutaneous system has the double dominant of drug administration by injection and transdermal administration, drug transdermal speed can be improved
Rate and absorbtivity.Main micropin administering mode has: puncture after coating, is coated with, hollow microneedles, degradable micropin after puncture
Etc..Aforementioned four scheme is in terms of effect assessment, and first mode operates more complicated and drug loading is limited；Second side
But it is relatively low that formula operates relatively easy anti-infection ability；3rd mode has then evaded the shortcoming of the former two, but the difficult point concentrated
The difficulty and the material that are embodied in micropin making select；Last one is the most popular direction, falls within integrated
Scheme.
Summary of the invention
A kind of collection coating is provided in place of it is an object of the invention to overcome above-mentioned the deficiencies in the prior art, punctures and transmit
Three processes are integrated, simplify the microneedle array plaster of micropin dosing step；Meanwhile, the invention also discloses described micropin battle array
The preparation method of row plaster.
For achieving the above object, the technical scheme that the present invention takes is: a kind of microneedle array plaster, wraps the most successively
Include adhered layer, microneedle array layer and elastic drug-loaded layer；
Described microneedle array layer includes that microneedle array substrate and microneedle array, described microneedle array are located at described microneedle array
The upper surface of substrate, the lower surface of described microneedle array substrate is fixed on described adhered layer；
Described microneedle array inserts described elastic drug-loaded layer from the lower surface of described elastic drug-loaded layer, and described micropin battle array
The top of row does not penetrates the upper surface of described elastic drug-loaded layer；
Described elastic drug-loaded layer comprises elastomeric material and the medicine being distributed in described elastomeric material.
Microneedle array plaster of the present invention, adds elastic drug-loaded layer as medicine controlled releasing interlayer, during use, by described
Microneedle array plaster is directly adhered on skin, then presses, the outer surface of adhered layer with the elastic drug-loaded layer of contact skin
Compression, thus the microneedle array being inserted in described elastic drug-loaded layer can penetrate elastic drug-loaded layer upper surface and thrust skin, thus
Form microwell array administration channel.At the end of pressing, described elastic drug-loaded layer resiles, and microneedle array exits skin, and moves back
Returning in described elastic drug-loaded layer, owing to containing medicine in described elastic drug-loaded layer, now elastic drug-loaded layer is administered by micropore
Passage is administered continuously.During use, can repeatedly press the outer surface of adhered layer, to prevent micropore administration channel reparation from closing, complete
Persistently slow control percutaneous dosing, and adjust medicine transmission speed and transmission quantity.Therefore, microneedle array plaster of the present invention is by skilful
The described elastic drug-loaded layer of wonderful increase, and utilize elastic drug-loaded layer characteristic and with the position relationship of microwell array, not only will be coated with
Cloth, puncture and transmit three during integrated, and be effectively simplified micropin be administered step.
As the preferred implementation of microneedle array plaster of the present invention, the elastomeric material in described elastic drug-loaded layer is
Hydrogel or elastic porous material.Heretofore described elastic drug-loaded layer is used as medicine controlled releasing interlayer, elastomeric material therein
In storing different types of macromolecular drug, vaccine etc., simultaneously work as protecting microneedle array, preventing from fractureing, avoiding antibacterial to pass through
Microwell array administration channel infects.Described elastic drug-loaded layer can be with percutaneous Continuous slow release medicine, its effective slow-release time and speed
Mainly regulated and controled by the medicament contg etc. in the elastic drug-loaded layer of change.As microneedle array plaster of the present invention more preferably
Embodiment, the elastomeric material in described elastic drug-loaded layer be preferably but not limited to hydrogel (such as hyaluronic acid gel etc.),
Elastic porous material (such as sponge etc.) etc..
In microneedle array plaster of the present invention, the medicine in described elastic drug-loaded layer is generally influenza vaccines or insulin
Deng macromolecular drug；The drug loading of described elastic drug-loaded layer regards concrete medicament categories, the selection of elastic drug-loaded layer elastomeric material
Different Deng difference, it is preferable that in described elastic drug-loaded layer, the volume V of described medicine is at about 100uL.On this basis,
For gel like material, medication amount be cV, c be the molal volume concentration of medicine；And for adsorbing the porous material of drug solution,
Medication amount is then fcV, and wherein f is porosity.
As the preferred implementation of microneedle array plaster of the present invention, in described elastic drug-loaded layer, described medicine is equal
Even it is distributed in described elastomeric material.
As the preferred implementation of microneedle array plaster of the present invention, the top of described microneedle array and described elasticity
The distance of the upper surface of drug-loaded layer is 500 microns.The top of microneedle array of the present invention and the upper table of described elastic drug-loaded layer
The distance in face has no particular limits, usually, when the upper surface of top and the described elastic drug-loaded layer of described microneedle array
When distance is the least, during use, by microneedle array plaster is applied smaller pressure, microneedle array will penetrate elastic medicine carrying
Layer upper surface thrusts skin, thus forms microwell array administration channel, and it is longer to penetrate into the micropin in skin；And when described
When the top of microneedle array is the biggest with the distance of the upper surface of described elastic drug-loaded layer, during use, need microneedle array plaster
Apply bigger pressure, microneedle array just can penetrate the upper surface of elastic drug-loaded layer thrust skin thus formed microwell array to
Medicine passage, and it is shorter to penetrate into the micropin in skin.Present inventor finds, when described micropin through lot of experiments research
When the distance of the upper surface of the top of array and described elastic drug-loaded layer is 500 microns, during use, microneedle array plaster is applied
Pressure size most suitable, the micropin length penetrating into skin is the most most suitable, and the using effect of now microneedle array plaster
Best.
As the preferred implementation of microneedle array plaster of the present invention, the length of described adhered layer is more than described micropin
Array layer, and the surface that described adhered layer is connected with described microneedle array substrate is provided with cohesive material.When described adhered layer
When length is more than described microwell array layer, described adhered layer understands some length beyond microwell array layer, due to described viscous
The surface that paste layer is connected with described microneedle array substrate is provided with cohesive material, i.e. beyond adhered layer upper of described microwell array layer
Surface has viscosity, during use can directly by this bonding partially of adhered layer at skin surface, and microwell array layer and elastic carry
Medicine layer is covered by between described adhered layer and skin.
As the preferred implementation of microneedle array plaster of the present invention, described microneedle array uses rustless steel, PMMA
The composite of material, epoxy resin, band biocompatible coating or coating is prepared from.During use, described micropin needs thorn
Entering skin and form microwell array administration channel, therefore, described microneedle array preferably has the biocompatible material of certain rigidity, tool
Body may select rustless steel, PMMA material, epoxy resin, band biocompatible coating or the composite etc. of coating.
As the preferred implementation of microneedle array plaster of the present invention, described microneedle array is the square battle array of 8 × 8
Row, in described microneedle array, the spacing between adjacent two micropins is 1 millimeter, and micropin in described microneedle array is a height of 1500 micro-
Rice, for a length of 500 microns of piercing portions, piercing portions maximum gauge is less than 200 microns.
As the preferred implementation of microneedle array plaster of the present invention, described adhered layer is medical proof fabric.Described viscous
Paste layer is mainly used in the stickup of microneedle array plaster of the present invention, owing to described adhered layer needs to be affixed directly to skin table
Face, the most described adhered layer material requirements has good skin biocompatibility, it is preferable that described adhered layer uses medical adhesive
Cloth.
As the preferred implementation of microneedle array plaster of the present invention, the material of described microneedle array substrate is silicon
Glue.Described microneedle array substrate primarily serves and supports microneedle array and the effect of elastic drug-loaded layer, and described microneedle array substrate is wanted
Ask and there is certain hardness, it is preferable that the material of described microneedle array substrate is silica gel.
It addition, the present invention also provides for a kind of simple to operate, preparation side of microneedle array plaster described above of being easily achieved
Method, for realizing this purpose, the technical scheme that the present invention takes is: the preparation method of a kind of microneedle array plaster described above, bag
Include following steps:
(1) take microneedle array substrate, then the upper surface in microneedle array substrate makes microneedle array, and to making
Microneedle array surface carries out biocompatibility modifying agent cleaning and sterilizing；
(2) by elastomeric material and medicament mixed, mix preparation is made；
(3) mix preparation that step (2) prepares added on microneedle array and make described mix preparation solidify, from
And on described microneedle array, form elastic drug-loaded layer；
(4) adhered layer is attached to the lower surface of described microneedle array substrate, obtains microneedle array plaster of the present invention.
Use as in the preferred implementation of the preparation method of microneedle array plaster of the present invention, described step (3)
The mix preparation that step (2) prepares is added on microneedle array by spin coating method.
In the preparation method of microneedle array plaster of the present invention, first the upper surface in microneedle array substrate makes micropin battle array
Row, then add to the mix preparation of elastomeric material with medicament mixed on microneedle array, and make described mix preparation exist
Solidify on microneedle array, form elastic drug-loaded layer.In this operating process, during the solidification of described mix preparation, microneedle array
Rest in described mix preparation, and finally make described microneedle array be positioned at described elastic drug-loaded layer, and be not perforated through described
The upper surface of elastic drug-loaded layer.Finally adhered layer is attached to the lower surface of described microneedle array substrate, is packaged storing i.e.
Can.
Microneedle array plaster of the present invention, is attached at described plaster on skin during use, microneedle array layer and elasticity
The drug-loaded layer laminating that is stuck is attached to described skin surface, and the outer surface of adhered layer is entered by described elastic drug-loaded layer and contact skin
Row pressing, under the effect of the pressure, elastic drug-loaded layer compression, so that the top of microneedle array penetrates described elastic drug-loaded layer
Upper surface and thrust skin, formed microwell array administration channel.Cancelling pressure after keeping certain time, pressing is elastic after terminating
Drug-loaded layer resiles, and microneedle array exits skin and returns in elastic drug-loaded layer, due to elastic drug-loaded layer contain medicine and
Directly and contact skin, the medicine in elastic drug-loaded layer is administered continuously through micropore administration channel.It is spaced between in due course or needs
When being again administered, again press, by compression frequency and compressing time etc., can effectively control medicine transmission speed and biography
Throughput rate.Microneedle array plaster of the present invention, the elastic drug-loaded layer adding the design of described ad hoc structure presss from both sides as medicine controlled releasing
Layer, creates the brand-new approach that micropin is administered, not only by coating, puncture, to transmit three process conformities integrated, and effectively
Simplify micropin dosing step.The preparation method of microneedle array plaster of the present invention, technique is simple, it is easy to industrialized production.
Accompanying drawing explanation
Fig. 1 is the structural representation of a kind of embodiment of microneedle array plaster of the present invention.
Fig. 2 is the schematic diagram that microneedle array plaster of the present invention is pasted on skin.
Fig. 3 is that microneedle array plaster of the present invention is pasted on the schematic diagram of piercing process on skin.
Fig. 4 is that microneedle array plaster of the present invention is pasted on the schematic diagram punctured on skin.
In figure, 10 be adhered layer, 20 for microneedle array layer, 22 for microneedle array substrate, 24 for microneedle array, 30 for elasticity
Drug-loaded layer, 32 be elastomeric material, 34 be medicine, 40 be skin, 50 for micropore administration channel.
Detailed description of the invention
For better illustrating the object, technical solutions and advantages of the present invention, below in conjunction with the drawings and specific embodiments pair
The present invention is described further.
Embodiment 1
A kind of embodiment of microneedle array plaster of the present invention, microneedle array plaster described in the present embodiment wraps the most successively
Include adhered layer 10, microneedle array layer 20 and elastic drug-loaded layer 30；
It is described that described microneedle array layer 20 includes that microneedle array substrate 22 and microneedle array 24, described microneedle array 24 are located at
The upper surface of microneedle array substrate 22, the lower surface of described microneedle array substrate 22 is fixed on described adhered layer 10；
Described microneedle array 24 inserts described elastic drug-loaded layer 30 from the lower surface of described elastic drug-loaded layer 30, and described
The top of microneedle array 24 does not penetrates the upper surface of described elastic drug-loaded layer 30；
Described elastic drug-loaded layer 30 comprises elastomeric material 32 and the medicine 34 being distributed in described elastomeric material 32.
It is preferred that the elastomeric material 32 in described elastic drug-loaded layer 30 is hydrogel (such as hyaluronic acid gel) or bullet
Property porous material (such as sponge).Described microneedle array 24 uses rustless steel, PMMA material, epoxy resin, band biocompatibility
The composite of coating or coating is prepared from.Described adhered layer 10 is medical proof fabric.The material of described microneedle array substrate 22
For silica gel.
It is preferred that in the present embodiment, the medicine 34 in described elastic drug-loaded layer 30 is that influenza vaccines or insulin etc. divide greatly
Sub-medicine, in described elastic drug-loaded layer 30, the volume of described medicine 34 is 100uL.More preferably, described medicine 34 is evenly distributed on
In the elastomeric material 32 of described elastic drug-loaded layer 30.
It is preferred that as shown in Figure 1, the upper surface of the top of described microneedle array 24 and described elastic drug-loaded layer 30 away from
From for 500 microns.Described microneedle array 24 is the square array of 8 × 8, in described microneedle array 24 between adjacent two micropins
Spacing is 1 millimeter, a height of 1500 microns of the micropin in described microneedle array, for a length of 500 microns of piercing portions, punctures
Part maximum gauge is less than 200 microns.
It is preferred that as shown in Figure 1, the length of described adhered layer 10 is more than described microneedle array layer 20, and described stickup
The surface that layer 10 is connected with described microneedle array substrate 22 is provided with cohesive material (being not drawn in figure).
Microneedle array plaster described in the present embodiment uses following methods to be prepared from:
(1) take microneedle array substrate, then the upper surface in microneedle array substrate makes microneedle array, and to making
Microneedle array surface carries out biocompatibility modifying agent cleaning and sterilizing；
(2) by elastomeric material and medicament mixed, mix preparation is made；
(3) the mix preparation spin coating mode that step (2) prepares is added on microneedle array and made described mixing
Preparation solidifies, thus forms elastic drug-loaded layer on described microneedle array；
(4) adhered layer is attached to the lower surface of described microneedle array substrate, obtains microneedle array plaster of the present invention.
Embodiment 2
The use embodiment of microneedle array plaster of the present invention
Microneedle array plaster of the present invention uses process as follows:
First, paste, as shown in Figure 2, first described microneedle array plaster is pasted and be on skin 40, microneedle array layer
20 and elastic drug-loaded layer 30 layer 10 that is stuck be attached to described skin 40 surface, described elastic drug-loaded layer 30 contacts with skin 40；
Secondly, pressing, as shown in Figure 3, the outer surface of adhered layer 10 is pressed, under the effect of the pressure, elastic
Drug-loaded layer 30 compresses, so that the top of microneedle array 24 penetrates surface that described elastic drug-loaded layer 30 contacts with skin 40 also
Thrust skin 40, form microwell array administration channel；
Finally, being administered, as shown in Figure 4, cancel pressure after keeping certain time, after pressing terminates, elasticity drug-loaded layer 30 is extensive
Restoring shape, microneedle array 24 exits skin 40 and returns in elastic drug-loaded layer 30, owing to elastic drug-loaded layer 30 is containing medicine 34
And directly contact with skin 40, the medicine 34 in elastic drug-loaded layer 30 is administered continuously through micropore administration channel 50.
During use, can according to circumstances, in due course between when being spaced or need again to be administered, again press, by pressing
Voltage-frequency rate and compressing time etc., can effectively control medicine transmission speed and transmission quantity.
Embodiment 3
The effect test of microneedle array plaster of the present invention
1, the structure of diabetes animal model
Selecting white mice 20, male, body weight 18.27 ± 0.63g, lumbar injection alloxan reagent, injection volume is
150mg/Kg, single cage is fed, and quantitatively drinks water and feeding.After fasting 12 hours, afterbody takes blood, detects blood glucose value with Instrument for Measuring Blood Sugar,
As blood glucose value >=10.0mmol/L,.
2, test packet
White mice in the diabetes animal model of structure is randomly divided into two groups, often group 10, respectively as matched group
And test group.
3, test method
Test group uses microneedle array plaster of the present invention, and wherein said elastic drug-loaded layer elastomeric material is 1mm
Thick sponge, described medicine is regular iletin, and the content of dispersion of described elastic drug-loaded layer is 100uL；Microneedle array use 8 ×
The square array of 8, in microneedle array, the spacing between adjacent two micropins is 1 millimeter, and the micropin in described microneedle array is a height of
1500 microns, for a length of 500 microns of piercing portions, piercing portions maximum gauge is less than 200 microns；The top of microneedle array
End is 500 microns with the distance of the upper surface of described elastic drug-loaded layer.
Microneedle array plaster described in the invention described above is pasted onto on the skin after test group white mice removes hair, micro-
Pin array layer and the elastic drug-loaded layer laminating that is stuck is attached to the skin surface of described white mice.The outer surface of adhered layer is applied about
10N/cm2Pressure press 1 second, then unclamp 9 seconds, be so repeated 3 times, the transdermal delivery of insulin can be completed.
Matched group white mice uses existing conventional micropin medication, the most first thrusts matched group white mice with micropin and removes
Keratodermatitis after hair, quickly extracts after producing small hole, then applies containing insulin on porose skin
Plaster.The micropin that matched group white mice uses is identical with test group white mice with the dosage of insulin.
After being administered 30min, 60min, 120min, 180min, 240min, test comparison group and test group white mice respectively
Blood sugar concentration, often group is averaged, and test result is as shown in table 1.
Matched group and the blood sugar concentration result of test group after table 1 administration
Be can be seen that by table 1 result, upon administration, mean blood glucose concentrations all has certain journey to the white mice of matched group and test group
The decline of degree, but the mean blood glucose concentrations of matched group white mice stops declining after being administered 120min, and test group white mice
Average blood sugar concentration of doing after being administered 240min, still there is downward trend.Thus prove, the microneedle array medicine of the present invention
Patch, not only by coating, puncture, to transmit three process conformities integrated, simplify micropin dosing step, and the present invention's be micro-
Pin array plaster is by the adjustment to compression frequency and compressing time, it is possible to effectively control transmission speed and the transmission quantity of medicine,
There is slow controlled-release effect.
Last institute is it should be noted that, the present invention is only protected by above example in order to technical scheme to be described
Protecting the restriction of scope, although being explained in detail the present invention with reference to preferred embodiment, those of ordinary skill in the art should
Understand, technical scheme can be modified or equivalent, without deviating from the essence of technical solution of the present invention
And scope.
Claims (10)
1. a microneedle array plaster, it is characterised in that include adhered layer, microneedle array layer and elastic medicine carrying the most successively
Layer；
Described microneedle array layer includes that microneedle array substrate and microneedle array, described microneedle array are located at described microneedle array substrate
Upper surface, the lower surface of described microneedle array substrate is fixed on described adhered layer；
Described microneedle array inserts described elastic drug-loaded layer from the lower surface of described elastic drug-loaded layer, and described microneedle array
Top does not penetrates the upper surface of described elastic drug-loaded layer；
Described elastic drug-loaded layer comprises elastomeric material and the medicine being distributed in described elastomeric material.
2. microneedle array plaster as claimed in claim 1, it is characterised in that the elastomeric material in described elastic drug-loaded layer is water
Gel or elastic porous material.
3. microneedle array plaster as claimed in claim 2, it is characterised in that the elastomeric material in described elastic drug-loaded layer is
Bright matter acid hydrogel or sponge.
4. the microneedle array plaster as described in any one of claims 1 to 3, it is characterised in that the top of described microneedle array with
The distance of the upper surface of described elastic drug-loaded layer is 500 microns.
5. microneedle array plaster as claimed in claim 1, it is characterised in that the length of described adhered layer is more than described micropin battle array
Row layer, and the surface that described adhered layer is connected with described microneedle array substrate is provided with cohesive material.
6. microneedle array plaster as claimed in claim 1, it is characterised in that described microneedle array uses rustless steel, PMMA material
The composite of material, epoxy resin, band biocompatible coating or coating is prepared from.
7. the microneedle array plaster as described in claim 1 or 6, it is characterised in that described microneedle array is the square battle array of 8 × 8
Row, in described microneedle array, the spacing between adjacent two micropins is 1 millimeter, and micropin in described microneedle array is a height of 1500 micro-
Rice, for a length of 500 microns of piercing portions, piercing portions maximum gauge is less than 200 microns.
8. microneedle array plaster as claimed in claim 1, it is characterised in that described adhered layer is medical proof fabric.
9. microneedle array plaster as claimed in claim 1, it is characterised in that the material of described microneedle array substrate is silica gel.
10. the preparation method of microneedle array plaster as described in any one of claim 1～9, it is characterised in that include following step
Rapid:
(1) taking microneedle array substrate, then the upper surface in microneedle array substrate makes microneedle array, and to the micropin made
Array surface carries out biocompatibility modifying agent cleaning and sterilizing；
(2) by elastomeric material and medicament mixed, mix preparation is made；
(3) mix preparation that step (2) prepares added on microneedle array and make described mix preparation solidify, thus
Elastic drug-loaded layer is formed on described microneedle array；
(4) adhered layer is attached to the lower surface of described microneedle array substrate, obtains microneedle array plaster of the present invention.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610694722.0A CN106176572A (en) | 2016-08-19 | 2016-08-19 | A kind of microneedle array plaster and preparation method thereof |
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| CN201610694722.0A CN106176572A (en) | 2016-08-19 | 2016-08-19 | A kind of microneedle array plaster and preparation method thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN109077938A (en) * | 2018-09-11 | 2018-12-25 | 中山大学 | A kind of microneedle array elastic hydrogel facial mask |
| CN110115707A (en) * | 2018-02-07 | 2019-08-13 | 华中科技大学 | A kind of method and its application preparing porous polymer micropin based on phase detachment technique |
| CN110505896A (en) * | 2017-05-22 | 2019-11-26 | 考司美德制药株式会社 | Water solubility makeup patch supporter |
| CN111467575A (en) * | 2020-04-17 | 2020-07-31 | 南京鼓楼医院 | Myocardial cell conductive microneedle patch integrated with induced pluripotent stem cell source and preparation method and application thereof |
| CN111836662A (en) * | 2018-03-13 | 2020-10-27 | 美德阿利克斯株式会社 | Adhesive member and microneedle patch |
| CN111956951A (en) * | 2019-12-17 | 2020-11-20 | 中山大学·深圳 | Iontophoresis micro-needle medicine patch and preparation method thereof |
| CN112494796A (en) * | 2020-12-02 | 2021-03-16 | 中山大学 | Pat cosmetic paster of formula micropin |
| CN112587790A (en) * | 2020-11-25 | 2021-04-02 | 中山大学 | Transdermal drug pressing/ion electrophoresis controlled release device based on 3D printing hollow microneedle array |
| CN113648530A (en) * | 2021-09-02 | 2021-11-16 | 中山大学 | Push type microneedle patch with double drug storage layers |
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| CN107007927A (en) * | 2017-02-21 | 2017-08-04 | 中山大学 | A kind of microneedle array drug paste and preparation method being administered based on electric field driven |
| CN110505896A (en) * | 2017-05-22 | 2019-11-26 | 考司美德制药株式会社 | Water solubility makeup patch supporter |
| CN110115707A (en) * | 2018-02-07 | 2019-08-13 | 华中科技大学 | A kind of method and its application preparing porous polymer micropin based on phase detachment technique |
| CN110115707B (en) * | 2018-02-07 | 2021-01-19 | 华中科技大学 | Method for preparing porous polymer microneedle based on phase separation technology and application thereof |
| CN111836662A (en) * | 2018-03-13 | 2020-10-27 | 美德阿利克斯株式会社 | Adhesive member and microneedle patch |
| CN109077938A (en) * | 2018-09-11 | 2018-12-25 | 中山大学 | A kind of microneedle array elastic hydrogel facial mask |
| CN111956951A (en) * | 2019-12-17 | 2020-11-20 | 中山大学·深圳 | Iontophoresis micro-needle medicine patch and preparation method thereof |
| CN111956951B (en) * | 2019-12-17 | 2022-09-09 | 中山大学·深圳 | Iontophoresis micro-needle medicine patch and preparation method thereof |
| CN111467575A (en) * | 2020-04-17 | 2020-07-31 | 南京鼓楼医院 | Myocardial cell conductive microneedle patch integrated with induced pluripotent stem cell source and preparation method and application thereof |
| CN112587790A (en) * | 2020-11-25 | 2021-04-02 | 中山大学 | Transdermal drug pressing/ion electrophoresis controlled release device based on 3D printing hollow microneedle array |
| CN112494796A (en) * | 2020-12-02 | 2021-03-16 | 中山大学 | Pat cosmetic paster of formula micropin |
| CN113648530A (en) * | 2021-09-02 | 2021-11-16 | 中山大学 | Push type microneedle patch with double drug storage layers |
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