CN106153895A - For detecting the device of bio information - Google Patents
For detecting the device of bio information Download PDFInfo
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- CN106153895A CN106153895A CN201510185084.5A CN201510185084A CN106153895A CN 106153895 A CN106153895 A CN 106153895A CN 201510185084 A CN201510185084 A CN 201510185084A CN 106153895 A CN106153895 A CN 106153895A
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Abstract
The present invention provides a kind of device for detecting bio information, and including magnetization unit, magnetosensitive chip and processing unit, wherein, described magnetization unit is for magnetizing the magnetic particle in test strips；Described magnetosensitive chip is for reading the magnetic signal in described test strips and obtaining output signal；Described processing unit is according to the bio information needed for the acquisition of described output signal.This measurement device precision is high, and simple in construction, volume is little, and processing cost is low.It addition, this device is applicable not only to large-scale detection equipment, and it is applicable to portable detection equipment.
Description
Technical field
The invention belongs to medical domain, relate to immunochromatography technique, be specifically related to a kind of for detecting bio information
Device.
Background technology
Immunochromatographic method is built upon the rapid free on the basis of chromatographic technique and Ag-Ab specific immune response
Epidemic disease diagnostic techniques.Through making great efforts the most untiringly, person skilled develops multiple exempting from based on immunochromatographic method
Epidemic disease chromatographic technique, such as chromatographic technique based on time resolved fluoro-immunoassay, fluorescent latex chromatographic technique, glimmering
Light micro-ball immune chromatography technology, colloidal gold immunochromatographimethod technology, magnetic bead immunochromatography technique and magnetic nano particle
Sub-immunochromatography technique.Wherein, magnetic nano-particle immunochromatography technique is with nano magnetic particle (also referred to as
Superparamagnetic particulates) it is label, this label combines the advantage of magnetic particle and nano material, has particle diameter
Little, superparamagnetism and the feature such as specific surface area is big, therefore, magnetic nano-particle immunochromatography technique was sent out in recent years
Exhibition is very fast.
Fig. 1 is the schematic diagram of magnetic nano-particle immunochromatography technique.As it is shown in figure 1, magnetic nano-particle is exempted from
Epidemic disease chromatographic technique is with fibre strip chromatographic material for chromatographic film 15, is provided with magnetic particle in pad 12 position even
Connection toxin specific antibody, chromatographs to combining when dripping the determinand being placed on sample pad 11 under the capillarity of fiber
When padding 12, coupling has the antigen in the magnetic particle identification determinand of toxin specific antibody, and specificity occurs with it
Immunoreation, forms the complex of antigen and magnetic particle, and then, determinand carries magnetic particle to be continued to chromatograph forward.
When determinand chromatography to T line (also known as holding wire or detection line), other epitope and setting in determinand
Toxin specific antibody generation specific immune response at T line, forms the sandwich structure of antibody-antigen-antibody,
Thus magnetic particle is caught at T line position.The magnetic granule not caught by T line continues to chromatograph forward, arrives C line
Time (also known as reference line or nature controlling line), the toxin specific antibody being coupled on magnetic granule be arranged at C line
There is immunoreation in anti-igg antibody (immunoglobulin G), thus by magnetic particle capture at C line position.
Detection by quantitative can be realized by the intensity of detection T line and C line position magnetic signal.
But, the accuracy of detection of the biological information detection device for magnetic nano-particle existing on market is relatively
Difference, affects diagnostic result, especially affects the result of rational judgment.
Summary of the invention
The technical problem to be solved in the present invention is aiming at drawbacks described above present in immunochromatography technique, it is provided that one
Planting the device for detecting bio information, certainty of measurement is high, and simple in construction, low cost.
To this end, the present invention provides a kind of device for detecting bio information, including: magnetization unit, magnetosensitive core
Sheet and processing unit, wherein, described magnetization unit is for magnetizing the magnetic particle in test strips；Described magnetosensitive chip,
Magnetic signal in reading described test strips, and obtain output signal；Described processing unit is according to described output
Bio information needed for signal acquisition.
Wherein, including: described magnetosensitive chip includes substrate, a plurality of magnetic induction film and multiple chip bonding pad, described
A plurality of magnetic induction film and described chip bonding pad are located at the surface of described substrate, and described a plurality of magnetic induction film connects formation
Wheatstone bridge, described chip bonding pad is corresponding with described magnetic induction film as the input/output terminal of described magnetosensitive chip
Electrical connection.
Wherein, described magnetosensitive chip includes magnetic induction film described in 2n bar and 3n described chip bonding pad, every two
Described magnetic induction film forms a favour stone half-bridge, forms n favour stone half-bridge, each described favour stone half-bridge altogether
It is provided with three described chip bonding pads；
Or, described magnetosensitive chip includes magnetic induction film described in 4m bar and 4n described chip bonding pad, every four
Described magnetic induction film forms a favour stone full-bridge, forms m favour stone full-bridge, each described favour stone full-bridge altogether
It is provided with four described chip bonding pads；
Wherein, n, m are the integer of >=1.
Wherein, described magnetic induction film is giant magnetoresistance effect film, Hall effect film, anisotropic magnetoresistive film, tunnel
Effect magnetoresistive film or giant Hall effect film.
Wherein, including support, described magnetosensitive chip and described magnetization unit are fixed on described support, and, institute
Stating magnetization unit and described magnetosensitive chip is oppositely arranged, described test strips is from described magnetization unit and described magnetosensitive core
Pass through between sheet.
Wherein, including circuit board, described circuit board is provided with amplifying circuit and filter circuit, described amplification electricity
Road is for amplifying the output signal that described magnetosensitive chip obtains；Described filter circuit is described for filter after amplification
Output signal, and by the transmission of described output signal to described processing unit；Described processing unit is to amplifying, filtering
After output signal process, and draw required bio information.
Wherein, including shell, described magnetosensitive chip, described magnetization unit, described support and described circuit board set
In shell.
Wherein, including display unit, for showing the bio information that described processing unit obtains.
Wherein, including memory element, for storing the bio information that described processing unit obtains.
Wherein, described magnetization unit is permanent magnet or coil.
Wherein, including multiple magnetosensitive chips, the plurality of magnetosensitive chip in reading described test strips respectively not
Magnetic information with region.
The method have the advantages that
The device for detecting bio information that the present invention provides, by magnetization unit by magnetic granule magnetic weak in test strips
Change, magnetosensitive chip the weak magnetic particle information being magnetized in reading test strips also obtains output signal, and processing unit depends on
Drawing required bio information according to described output signal, i.e. obtain testing result, this employing magnetosensitive chip reads examination
The mode of paper slip, certainty of measurement is high, can realize rational judgment, substantially increase the accuracy rate of diagnosis；And, knot
Structure is simple, and volume is little, and processing cost is low.It addition, this structure is applicable not only to the large-scale detection equipment of large volume,
And it is applicable to the portable detection equipment of small size.
Accompanying drawing explanation
Fig. 1 is the principle schematic of immunochromatography technique；
Fig. 2 is that the embodiment of the present invention is for detecting the structural representation of the device of bio information；
Fig. 3 is the structural representation of magnetosensitive chip in the embodiment of the present invention；
Fig. 4 is that another embodiment of the present invention is for detecting the structural representation of the device of bio information；
Fig. 5 is the schematic diagram of circuit board in the embodiment of the present invention；
Fig. 6 is that further embodiment of this invention is for detecting the structural representation of the device of bio information；
Fig. 7 is that another embodiment of the present invention is for detecting the structural representation of the device of bio information；
Fig. 8 is that yet another embodiment of the invention is for detecting the structural representation of the device of bio information；
Fig. 9 a is one embodiment of the invention signal when the device detection multichannel test strips detecting bio information
Figure, have employed two magnetosensitive chips in this schematic diagram；
Fig. 9 b is another embodiment of the present invention showing when the device detection multichannel test strips detecting bio information
It is intended to, this schematic diagram have employed a magnetosensitive chip.
Detailed description of the invention
For making those skilled in the art be more fully understood that technical scheme, below in conjunction with the accompanying drawings to this
The device being used for detecting bio information of bright offer is described in detail.
As in figure 2 it is shown, include magnetization unit 1, magnetosensitive chip 2, supporter for detecting the device of bio information
(not shown) and processing unit (not shown), magnetization unit 1 is raw for magnetized magnetic nano-particle
Magnetic particle in analyte detection test strips (hereinafter referred to as test strips), magnetization unit 1 uses permanent magnet or coil.
Coil can be to use helmholtz coil or the coil of other form.Magnetosensitive chip 2 is for reading in test strips
Magnetic signal, i.e. reads magnetic nanoparticle information in test strips, and obtains output signal.Processing unit is according to magnetic
The power of the output signal of quick chip 2, functional relationships between biomolecule concentration in magnetic numbers of particles-determinand
System, the magnetic field size of applying and frequency and distance variation relation, it is thus achieved that required bio information.
When detection, the nano-particle that is magnetic, magnetosensitive can be assembled in detection line T and the nature controlling line C region of test strips
The magnetic signal of chip 2 induced magnetism nano-particle, can be with output current signal, it is also possible to be voltage signal.This
Embodiment illustrates as a example by voltage signal.In fig 2 it is indicated by arrows that the moving direction of magnetosensitive chip 2.
As it is shown on figure 3, magnetosensitive chip 2 includes substrate 21, a plurality of magnetic induction film 22 and multiple chip bonding pad 23,
A plurality of magnetic induction film 22 and chip bonding pad 23 are located at the surface of substrate 21, and a plurality of magnetic induction film 22 connects formation
Wheatstone bridge, chip bonding pad 23 is as the input/output terminal electrical connection corresponding with magnetic induction film 21 of magnetosensitive chip.
In the present embodiment, magnetosensitive chip 2 includes two magnetic induction films 22 and three chip bonding pads 23, two
Magnetic induction film 22 and three chip bonding pads 23 connect into favour stone half-bridge.When magnetosensitive chip 2 senses magnetic field,
Favour stone half-bridge is affected at outfan output voltage signal by magnetic field.Magnetic induction film 22 can use giant magnetoresistance
(GMR) effect film, Hall (Hall) effect film, anisotropic magnetoresistance (AMR) effect film, tunnelling magnetic
Resistance (TMR) effect magnetoresistive film or giant Hall effect film.
It should be noted that in the present embodiment, magnetosensitive chip 2 can use other structure according to actual needs.
As magnetosensitive chip 2 includes 2n bar magnetic induction film 22 and 3n chip bonding pad 23, every two magnetic induction films 22
Forming a favour stone half-bridge, form n favour stone half-bridge altogether, each favour stone half-bridge is provided with three chip bonding pads
23；Or, magnetosensitive chip includes 4m bar magnetic induction film 22 and 4n chip bonding pad 23, every four magnetic induction
Film 22 forms a favour stone full-bridge, forms m favour stone full-bridge altogether, and each favour stone full-bridge is provided with 4 cores
Sheet pad 23；Wherein, n, m are the integer of >=1.
As shown in Figure 4, in another embodiment, the device being used for detecting bio information includes support 5, magnetosensitive core
Sheet 2 and magnetization unit 1 are fixed on support, and, magnetization unit 1 and magnetosensitive chip 2 are oppositely arranged, reagent paper
Bar passes through between magnetosensitive chip 2 and magnetization unit 1.So, single from magnetosensitive chip 2 and magnetization when test strips
When moving between unit 1, the magnetic granule in the magnetisable test strips of magnetization unit 1, magnetosensitive chip 2 can read reagent paper
Magnetic information on bar.Test strips relative movement between device can be realized by two ways, one, mobile
Test strips；Its two, traversing carriage, allow support drive magnetization unit 1 and magnetosensitive chip 2 to move.
It addition, also include circuit board 4 for detecting the device of bio information.Circuit board 4 is defeated with magnetosensitive chip 2
Go out end to connect.As it is shown in figure 5, be provided with amplifying circuit 41 and filter circuit 42 on the circuit board 4, wherein,
Amplifying circuit 41 is for amplifying the output signal that magnetosensitive chip 22 obtains；Filter circuit 42 is used for filtering amplification
After output signal.Processing unit 43 to amplify, filtered output signal process, and according to this process after
Output signal draw required bio information.It should be noted that processing unit 43 both may be disposed at circuit board
4, as shown in Figure 5.Certainly, processing unit 43 also can be separately set in other position in shell 5, or,
Processing unit 43 is arranged at the outside of shell 5, and such as, an external computer is as processing unit 43.
As shown in Figure 4, the device being used for detecting bio information may also include shell 5, magnetization unit 1, magnetosensitive core
Sheet 2, support and circuit board 4 are located in shell 5, i.e. magnetization unit 1, magnetosensitive chip 2 and circuit board 4
It is fixed on support, then places a stent in shell 5.Shell 5 had both protected magnetization unit 1, magnetosensitive chip
2, circuit board 4 and support, also improves the aesthetics of device.
Above magnetization unit 1, an object stage can be set.During detection, test strips is placed on object stage.And
And, distance piece also can be set between test strips and magnetosensitive chip 2, can be not only used for making magnetosensitive chip 2 and reagent paper
Constant distance between bar, can avoid again the cross infection between test strips, reduces signal intensity.Distance piece is adopted
With very thin sheet glass, piezoid, plastic sheeting or potsherd.
As shown in Figure 6, the device being used for detecting bio information also includes display unit 6, display unit 6 and process
Unit 43 connects, the bio information obtained by processing unit 43 for display.User can be by display unit
6 directly read biological data.
In the present embodiment, have employed two magnetosensitive chips 2 for detecting the device of bio information, and, two
Magnetosensitive chip 2 is each separately provided.In another embodiment, for detecting device one magnetic of employing of bio information
Quick chip 2, as it is shown in fig. 7, in figure, arrow represents the moving direction of magnetosensitive chip 2.
In the above-described embodiments, the device being used for detecting bio information is to realize detection by mobile magnetosensitive chip 2.
As long as it practice, making magnetosensitive chip 2 and test strips relative movement can realize detection.Such as, by mobile reagent paper
Bar realizes the relative motion of magnetosensitive chip 2 and test strips.And, the relative motion of magnetosensitive chip 2 and test strips was both
(paper can be perpendicular at the width of test strips again at the length direction (being parallel to paper direction) of test strips
Direction, face).
When magnetization unit 1 is permanent magnet, magnetic modulating part 7 also can be set between permanent magnet and test strips, its
Can be used for regulating the Distribution of Magnetic Field of permanent magnet, thus improve accuracy of detection.As shown in Figure 8, magnetic modulating part 7 is
" U " type structure, i.e. two opposite ends at magnetic modulating part 7 are respectively provided with a protuberance 71, and, protuberance 71
Extend towards test strips direction.Magnetic modulating part 7 uses high permeability material to make, and, magnetic modulating part 7 can
To be integrative-structure, it would however also be possible to employ lamination.
Preferably, also include memory element for detecting the device of bio information, be used for storing described processing unit
The bio information obtained.When user is individual, the history value of measurement can be stored in by memory element
In memory element, user just will appreciate that the situation of change of bio information by calling history value, thus preferably
Understand health status.
The device being used for detecting bio information of present invention offer cannot be only used for single channel test strips, it is also possible to is used for
Detection multichannel test strips.As Fig. 9 a and Fig. 9 b shows the device detection multichannel examination for detecting bio information
Schematic diagram during paper slip.Circumferencial direction in multichannel test strips is spaced and arranges multiple isolation area DS and test section TS,
Each test section TS can be used for testing identical bio information parameter, it is possible to is respectively used to test different biological letters
Breath parameter.When multichannel test strips is rotated about their axes, the magnetic of magnetosensitive chip 2 read test district TS respectively is received
Rice grain bio information.Owing to adjacent two test section TS are isolated district DS isolation, when magnetosensitive chip 2 by every
When district DS, magnetosensitive chip 2 not output, therefore, magnetosensitive chip 2 can be by isolation area DS by adjacent survey
The output signal difference of examination district TS, thus avoid the confusion of output signal.
The device for detecting bio information that the various embodiments described above provide, by magnetization unit by magnetic weak in test strips
Granulated magnetic, magnetosensitive chip the weak magnetic particle information being magnetized in reading test strips also obtains output signal, processes
Unit draws required bio information according to described output signal, i.e. obtains testing result, this employing magnetosensitive chip
Reading the mode of test strips, certainty of measurement is high, and measuring accuracy is high, can realize rational judgment, substantially increase diagnosis
Accuracy rate；And, also having the advantage that signal to noise ratio is high, oneself power consumption is low, fast response time, reliability
Height, simple in construction, volume is little, and processing cost is low.It addition, this structure is applicable not only to the large-scale inspection of large volume
Measurement equipment, and it is applicable to the portable detection equipment of small size.
It is understood that the principle that is intended to be merely illustrative of the present of embodiment of above and use exemplary
Embodiment, but the invention is not limited in this.For those skilled in the art, not
In the case of departing from spirit and substance of the present invention, various modification and improvement can be made, these modification and improvement
It is also considered as protection scope of the present invention.
Claims (11)
1. one kind for detecting the device of bio information, it is characterised in that including: magnetization unit, magnetic chip and
Processing unit, wherein, described magnetization unit is for magnetizing the magnetic particle in test strips；Described magnetic chip, is used for
Read the magnetic signal in described test strips, and obtain output signal；Described processing unit is according to described output signal
Bio information needed for acquisition.
Device for detecting bio information the most according to claim 1, it is characterised in that including: institute
State magnetic chip and include substrate, a plurality of magnetic induction film and multiple chip bonding pad, described a plurality of magnetic induction film and described core
Sheet pad is located at the surface of described substrate, and described a plurality of magnetic induction film connects formation Wheatstone bridge, described chip
Pad is as the input/output terminal electrical connection corresponding with described magnetic induction film of described magnetic chip.
Device for detecting bio information the most according to claim 2, it is characterised in that described magnetic core
Sheet includes magnetic induction film described in 2n bar and 3n described chip bonding pad, and every two described magnetic induction films form a favour
Stone half-bridge, forms n favour stone half-bridge altogether, and each described favour stone half-bridge is provided with three described chip bonding pads；
Or, described magnetic chip includes magnetic induction film described in 4m bar and 4n described chip bonding pad, every four institutes
Stating magnetic induction film and form a favour stone full-bridge, form m favour stone full-bridge altogether, each described favour stone full-bridge sets
There are four described chip bonding pads；
Wherein, n, m are the integer of >=1.
Device for detecting bio information the most according to claim 2, it is characterised in that described magnetic strength
Answering film is giant magnetoresistance effect film, Hall effect film, anisotropic magnetoresistive film, tunnel-effect magnetoresistive film or huge Hall
Effect film.
Device for detecting bio information the most according to claim 1, it is characterised in that include supporting
Parts, described magnetic chip and described magnetization unit are fixed on described support member, and, described magnetization unit and
Described magnetic chip is oppositely arranged, and described test strips is passed through between described magnetization unit and described magnetic chip.
Device for detecting bio information the most according to claim 5, it is characterised in that include circuit
Plate, is provided with amplifying circuit and filter circuit on described circuit board, and described amplifying circuit is used for amplifying described magnetic core
The output signal that sheet obtains；The described filter circuit described output signal after filtering amplification, and by described defeated
Go out signal transmission to described processing unit；Amplification, filtered output signal are processed by described processing unit,
And draw required bio information.
Device for detecting bio information the most according to claim 6, it is characterised in that include shell,
Described magnetic chip, described magnetization unit, described support member and described circuit board are located in shell.
Device for detecting bio information the most according to claim 6, it is characterised in that include display
Parts, for showing the bio information that described processing unit obtains.
Device for detecting bio information the most according to claim 1, it is characterised in that include storage
Unit, for storing the bio information that described processing unit obtains.
Device for detecting bio information the most according to claim 1, it is characterised in that described magnetic
Changing unit is permanent magnet or coil.
11. devices for detecting bio information according to claim 1, it is characterised in that include many
Individual magnetic chip, the plurality of magnetic chip is the magnetic information of zones of different in reading described test strips respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510185084.5A CN106153895A (en) | 2015-04-17 | 2015-04-17 | For detecting the device of bio information |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510185084.5A CN106153895A (en) | 2015-04-17 | 2015-04-17 | For detecting the device of bio information |
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| CN201510185084.5A Pending CN106153895A (en) | 2015-04-17 | 2015-04-17 | For detecting the device of bio information |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106950362A (en) * | 2017-03-18 | 2017-07-14 | 上海辽浦生物科技有限公司 | The measuring method and device of a kind of immune magnetic test strips |
| CN107561272A (en) * | 2017-08-24 | 2018-01-09 | 苏州万纳生物科技有限公司 | Test strips, detection carry the method and device of the test strips for the aggregation that is magnetic |
| CN110470834A (en) * | 2019-09-22 | 2019-11-19 | 河南工业大学 | A kind of aflatoxin B1 detection method of content based on magnetic signal |
| CN112816542A (en) * | 2021-01-04 | 2021-05-18 | 武汉市合众电气设备制造有限公司 | Trace iron powder detection device based on giant magnetoresistance effect |
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| WO2007107858A1 (en) * | 2006-03-21 | 2007-09-27 | Legastelois Stephane | Magnetic immunochromatographic test method and device |
| CN201397331Y (en) * | 2009-04-24 | 2010-02-03 | 无锡纳生生物科技有限公司 | Magnetic nanometer immunochromatography card reading device |
| CN103364543A (en) * | 2013-07-03 | 2013-10-23 | 中国科学院宁波材料技术与工程研究所 | Magnetic mark biosensor system |
| CN203759709U (en) * | 2013-12-24 | 2014-08-06 | 北京嘉岳同乐极电子有限公司 | Card reader |
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Patent Citations (4)
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| WO2007107858A1 (en) * | 2006-03-21 | 2007-09-27 | Legastelois Stephane | Magnetic immunochromatographic test method and device |
| CN201397331Y (en) * | 2009-04-24 | 2010-02-03 | 无锡纳生生物科技有限公司 | Magnetic nanometer immunochromatography card reading device |
| CN103364543A (en) * | 2013-07-03 | 2013-10-23 | 中国科学院宁波材料技术与工程研究所 | Magnetic mark biosensor system |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106950362A (en) * | 2017-03-18 | 2017-07-14 | 上海辽浦生物科技有限公司 | The measuring method and device of a kind of immune magnetic test strips |
| CN106950362B (en) * | 2017-03-18 | 2019-07-16 | 上海叶民生物技术有限公司 | A kind of measurement method and device of immune magnetic test strips |
| CN107561272A (en) * | 2017-08-24 | 2018-01-09 | 苏州万纳生物科技有限公司 | Test strips, detection carry the method and device of the test strips for the aggregation that is magnetic |
| CN110470834A (en) * | 2019-09-22 | 2019-11-19 | 河南工业大学 | A kind of aflatoxin B1 detection method of content based on magnetic signal |
| CN112816542A (en) * | 2021-01-04 | 2021-05-18 | 武汉市合众电气设备制造有限公司 | Trace iron powder detection device based on giant magnetoresistance effect |
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