CN106139399B - A kind of electric pulse stimulation test device and the test system using the device - Google Patents
A kind of electric pulse stimulation test device and the test system using the device Download PDFInfo
- Publication number
- CN106139399B CN106139399B CN201610628487.7A CN201610628487A CN106139399B CN 106139399 B CN106139399 B CN 106139399B CN 201610628487 A CN201610628487 A CN 201610628487A CN 106139399 B CN106139399 B CN 106139399B
- Authority
- CN
- China
- Prior art keywords
- frequency
- stimulation
- pulse
- electric
- hertz
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000000638 stimulation Effects 0.000 title claims abstract description 347
- 238000012360 testing method Methods 0.000 title claims abstract description 102
- 238000006243 chemical reaction Methods 0.000 claims abstract description 63
- 208000024891 symptom Diseases 0.000 claims abstract description 61
- 230000004936 stimulating effect Effects 0.000 claims description 22
- 238000000338 in vitro Methods 0.000 claims description 19
- 210000001367 artery Anatomy 0.000 claims description 9
- 210000003462 vein Anatomy 0.000 claims description 9
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 238000005424 photoluminescence Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 description 18
- 230000000694 effects Effects 0.000 description 14
- 230000005021 gait Effects 0.000 description 13
- 238000010586 diagram Methods 0.000 description 10
- 238000002513 implantation Methods 0.000 description 8
- 230000006872 improvement Effects 0.000 description 8
- 208000018737 Parkinson disease Diseases 0.000 description 7
- 210000004556 brain Anatomy 0.000 description 7
- 230000005611 electricity Effects 0.000 description 6
- 201000008482 osteoarthritis Diseases 0.000 description 6
- 208000002740 Muscle Rigidity Diseases 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 210000005036 nerve Anatomy 0.000 description 4
- 239000000560 biocompatible material Substances 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000007943 implant Substances 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 2
- 206010044565 Tremor Diseases 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000004126 nerve fiber Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 238000004080 punching Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010052804 Drug tolerance Diseases 0.000 description 1
- 208000008238 Muscle Spasticity Diseases 0.000 description 1
- 230000003556 anti-epileptic effect Effects 0.000 description 1
- 230000000648 anti-parkinson Effects 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 239000000939 antiparkinson agent Substances 0.000 description 1
- 230000000386 athletic effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 230000026781 habituation Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000007383 nerve stimulation Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000001272 neurogenic effect Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000018198 spasticity Diseases 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000001186 vagus nerve Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36003—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of motor muscles, e.g. for walking assistance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36067—Movement disorders, e.g. tremor or Parkinson disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36125—Details of circuitry or electric components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36167—Timing, e.g. stimulation onset
- A61N1/36171—Frequency
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36167—Timing, e.g. stimulation onset
- A61N1/36175—Pulse width or duty cycle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/37—Monitoring; Protecting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/38—Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
- A61N1/39—Heart defibrillators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/38—Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
- A61N1/39—Heart defibrillators
- A61N1/3925—Monitoring; Protecting
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Electrotherapy Devices (AREA)
Abstract
The present invention relates to a kind of electric pulse stimulation test device, it is practically applicable to the patient for having used constant frequency to stimulate one period and subsidiary ill symptoms comprising:One pulse generating module, the pulse generating module can at least generate frequency conversion stimulation pulse signal, the frequency conversion stimulation pulse signal includes that the electric stimulation pulse string alternating stimulation of at least two different frequencies forms multiple burst periods, and the electric stimulation pulse string of each frequency duration in each burst periods is 0.1 second ~ 60 minutes;The frequency of stimulation of the frequency conversion stimulation pulse signal is determined by following steps:Record the primary frequency A that the patient uses constant frequency stimulation;Make the impulse stimulation of the impulse generator output constant frequency patient, and records the patient and be attached to the pulse frequency B that symptom is improved;And according to formula C=A2The frequency of stimulation that the frequency C, the B and C that a correspondence uses are the frequency conversion stimulation pulse signal is calculated in/B.
Description
This case is filed in 29 days April in 2015 application No. is 201510211704.8, a kind of entitled " electric pulse stimulation
The division of the Chinese invention patent application of test device and the test system for using the device ".In December, 2014 is advocated in this case
It is entitled " a kind of electric pulse stimulation test device and to use the device application No. is 201410849257.4 filed in 31 days
Test system " Chinese invention patent application domestic priority.
Technical field
The invention belongs to mini-medical instrument field, more particularly to a kind of implanted electric pulse stimulation system that medical treatment uses
System, a kind of electric pulse stimulation test system and the method using implanted electric pulse stimulation system stimulation nerve fiber.
Background technology
There are many implantation medical equipment type, such as pacemaker and defibrillator, embedded nerve stimulator, implanted flesh
Meat stimulator etc..Implantation medical equipment generally comprises et al. Ke device and outer control device, between the two by two-way
Wireless telecommunications exchange information.
In existing technology, implantation medical equipment generally utilizes battery powered, sends out the boost pulse of specific frequency,
Long-time stimulus is carried out to specific target spot, so as to improve the symptom of patient.This stimulus modality is referred to as constant frequency stimulus modality.In constant frequency
Under stimulus modality, single-frequency typically lasts for the stimulation time of target spot several days or more, some months or even several years.But it is clinical
From the point of view of, existing stimulating method is to the ineffective of certain symptoms and will produce certain adaptability.For example, being directed to parkinson symptom
Deep brain stimulation, under the stimulation of constant frequency, dysarthrosis, gait are freezed, the non-motor symptoms such as unusual fluctuation improve it is little.Separately
Outside, according to the nerve electric stimulation Couple herbs to anti-Parkinson and epileptic, patient is under the stimulation of constant frequency, easy pair
Stimulation generates adaptability so that therapeutic effect is deteriorated, and is similarly to the drug resistance to reusing drug generation for a long time.
Moreover, the application method of implantation medical equipment is typically that stimulating electrode (is included or do not wrapped by operation at present
Containing extension lead), impulse generator be all implanted into the human body, wait for postoperative recovery several weeks, then open impulse generator into
It assassinates and swashs, observation and assessment effect of stimulation.However some patientss there are symptom improve unobvious or without improve the case where, need at this time
Take out implantation material.In practice for observing and assessing effect of stimulation, it is chronically implanted the impulse generator used and extension lead not
It is necessary, and the surgical procedure being implanted into needed for two components causes patient larger physical impairment.Therefore, for this portion
To divide for patient, current procedure pattern exists there are two drawback, when the waste of instrument, second is that the excessive use of operation.In order to
Avoid above-mentioned drawback, it is thus proposed that first patient is observed and assessed using electric pulse stimulation test system.For example, first only existing
Then the stimulating electrode is electrically connected by patient's body implantable stimulation electrode with electric pulse stimulation test system.Pass through the electricity arteries and veins
Spurt swashs test system and is tested, and observes and assess to determine the patient if appropriate for electrical stimulating therapy.However, existing
Electric pulse stimulation test system is only capable of testing the constant frequency stimulus modality of single-frequency.
Invention content
In view of this, it is necessory to provide it is a kind of may be implemented frequency conversion stimulation electric pulse stimulation test device and test be
System.
A kind of electric pulse stimulation test device is practically applicable to that constant frequency has been used to stimulate one period and is attached to bad
The patient of symptom comprising:One testing in vitro stimulator and a test lead, and the testing in vitro stimulator includes a pulse
Module occurs, the pulse generating module can at least generate frequency conversion stimulation pulse signal, which includes
Alternately stimulation forms multiple burst periods, and the electro photoluminescence arteries and veins of each frequency to the electric stimulation pulse string of at least two different frequencies
Punching string duration in each burst periods is 0.1 second~60 minutes;Wherein, the stimulation of the frequency conversion stimulation pulse signal
Frequency is determined by following steps:
Record the primary frequency A that the patient uses constant frequency stimulation;
Make the impulse stimulation patient of impulse generator output constant frequency, and records the patient and be attached to symptom and improved
Pulse frequency B;And
According to formula C=A2It is frequency conversion thorn that the frequency C, the frequency B and frequency C that a correspondence uses, which is calculated, in/B
The frequency of stimulation of flyback pulse signal.
Such as above-mentioned electric pulse stimulation test device, further, the electric stimulation pulse string of each frequency is in each train of pulse week
Interim duration is 0.1 second~30 minutes;Preferably, the electric stimulation pulse string of each frequency is in each burst periods
Duration is 3 seconds~60 seconds;It is highly preferred that the electric stimulation pulse string of each frequency is lasting in each burst periods
Time is 5 seconds~30 seconds.
Such as above-mentioned electric pulse stimulation test device, further, the frequency of the electric stimulation pulse string is 10 hertz~400 hertz
Hereby;Preferably, the frequency of the electric stimulation pulse string is 30 hertz~250 hertz;It is highly preferred that the electric stimulation pulse string
Frequency is 50 hertz~150 hertz.
Such as above-mentioned electric pulse stimulation test device, further, the number of the electric stimulation pulse string of the different frequency is N,
And 2≤N<10, and time ratio of the electric stimulation pulse string of the different frequency in each burst periods is more than 5%.
Such as above-mentioned electric pulse stimulation test device, further, between the electro photoluminescence arteries and veins string of the different frequency it is spaced certain
Time, and the time interval between the electric stimulation pulse string of two neighboring different frequency is 0.01 second~60 minutes;Or it is described more
Separated in time between a burst periods, and the time interval between two neighboring burst periods is 0.01 second~60 points
Clock.
Such as above-mentioned electric pulse stimulation test device, further, the appearance sequence of each period moderate stimulation train of pulse is by frequency
Rate reaches from small, or occurs from big to small or at random.
Such as above-mentioned electric pulse stimulation test device, further, the pulse generating module also has single-frequency frequency sweep work(
Energy;The single-frequency frequency sweep function is:When setting the swept frequency range as F1min~F1max, frequency sweep precision is S1, sweep time
For T1, the pulse generating module will be with F1min, F1min+S1, F1min+2S1, F1min+3S1 ... F1min+nS1 and
F1max exports an electric stimulation pulse string respectively, and each electric stimulation pulse string duration is T1, wherein n is natural number, and n
≤(F1max-F1min)/S1。
Such as above-mentioned electric pulse stimulation test device, further, the frequency and amplitude of the electric stimulation pulse string are adjustable simultaneously;
Or the frequency and pulse width of the electric stimulation pulse string are adjustable simultaneously.
A kind of electric pulse stimulation test device is practically applicable to that constant frequency has been used to stimulate one period and is attached to bad
The patient of symptom comprising:One testing in vitro stimulator and a test lead, and the testing in vitro stimulator includes a pulse
Module occurs, the pulse generating module can at least generate frequency conversion stimulation pulse signal;Wherein, the frequency conversion stimulation pulse signal
Frequency of stimulation determined by following steps:
Record the primary frequency A that the patient uses constant frequency stimulation;
Make the impulse stimulation patient of impulse generator output constant frequency, and records the patient and be attached to symptom and improved
Pulse frequency B;And
According to formula C=A2It is frequency conversion thorn that the frequency C, the frequency B and frequency C that a correspondence uses, which is calculated, in/B
The frequency of stimulation of flyback pulse signal.
A kind of electric pulse stimulation test device is practically applicable to that constant frequency has been used to stimulate one period and is attached to bad
The patient of symptom comprising:One testing in vitro stimulator and a test lead, and the testing in vitro stimulator includes a pulse
Module occurs, the pulse generating module can at least generate frequency conversion stimulation pulse signal, which only wraps
The electric stimulation pulse string alternating stimulation for including three kinds of different frequencies forms multiple burst periods;Wherein, which believes
Number frequency of stimulation determined by following steps:
Record the primary frequency A that the patient uses constant frequency stimulation;
Make the impulse stimulation of the impulse generator output constant frequency patient, and records the two different subsidiary diseases of the patient
The pulse frequency B that shape is improved1And B2;And
According to formula C=A2/B1The frequency C that a correspondence uses is calculated, according to formula D=A2/B2It is calculated another
The corresponding frequency D, described frequency B, C, D used is the frequency of stimulation of the frequency conversion stimulation pulse signal of three kinds of different frequencies.
A kind of electric pulse stimulation test system comprising:One electric pulse stimulation test device and a stimulating electrode,
In, the electric pulse stimulation test device is such as any one in above-mentioned electric pulse stimulation test device.
Compared with prior art, electric pulse stimulation test device of the invention or test system are by introducing frequency conversion stimulation
Pulse signal can be used for testing patient and be treated if appropriate for using frequency conversion stimulation pulse signal.
Description of the drawings
Fig. 1 is the structural schematic diagram of implanted electric pulse stimulation system provided in an embodiment of the present invention.
Fig. 2 is the module diagram of the impulse generator of the implanted electric pulse stimulation system of Fig. 1.
Fig. 3 is the frequency conversion stimulation pulse signal of implanted electric pulse stimulation system provided in an embodiment of the present invention and existing skill
The comparison diagram of the constant frequency stimulation pulse signal of art.
Fig. 4 is the first frequency conversion boost pulse letter that implanted electric pulse stimulation system provided in an embodiment of the present invention generates
Number schematic diagram.
Fig. 5 is second of frequency conversion boost pulse letter that implanted electric pulse stimulation system provided in an embodiment of the present invention generates
Number schematic diagram.
Fig. 6 is the third frequency conversion boost pulse letter that implanted electric pulse stimulation system provided in an embodiment of the present invention generates
Number schematic diagram.
Fig. 7 is the 4th kind of frequency conversion boost pulse letter that implanted electric pulse stimulation system provided in an embodiment of the present invention generates
Number schematic diagram.
Fig. 8 is the 5th kind of frequency conversion boost pulse letter that implanted electric pulse stimulation system provided in an embodiment of the present invention generates
Number schematic diagram.
Fig. 9 is the first frequency sweep mould of the impulse generator of implanted electric pulse stimulation system provided in an embodiment of the present invention
The frequency-time relational graph of the electric stimulation pulse signal of formula.
Figure 10 is second of frequency sweep of the impulse generator of implanted electric pulse stimulation system provided in an embodiment of the present invention
The frequency-time relational graph of the electric stimulation pulse signal of pattern.
Figure 11 is the third frequency sweep of the impulse generator of implanted electric pulse stimulation system provided in an embodiment of the present invention
The frequency-time relational graph of the electric stimulation pulse signal of pattern.
Figure 12 is the 4th kind of frequency sweep of the impulse generator of implanted electric pulse stimulation system provided in an embodiment of the present invention
The frequency-time relational graph of the electric stimulation pulse signal of pattern.
Figure 13 is the structural schematic diagram that electric pulse stimulation provided in an embodiment of the present invention tests system.
Figure 14 is the module diagram that the electric pulse stimulation of Figure 13 tests the pulse generating module of system.
Main element symbol description
Implanted lesions located in deep brain device 10
Impulse generator 11
Microprocessor module 111,211
Power module 112,212
Wireless communication module 114
Stimulating electrode 12
Extension lead 13
Vitro program controlled instrument 14
Electric stimulation pulse signal 15
Frequency conversion stimulation pulse signal 150
Burst periods 151
Electric stimulation pulse string 152
Time interval 154
Electric pulse stimulation tests system 20
Testing in vitro stimulator 21
Pulse generating module 210
Control module 213
Test cable 22
Test lead 23
Following specific implementation mode will be further illustrated the present invention in conjunction with above-mentioned attached drawing.
Specific implementation mode
Below in conjunction with the accompanying drawings and the specific embodiments, to implanted electric pulse stimulation system provided by the invention, electric pulse
Stimulate test system, and the method using implanted electric pulse stimulation system stimulation nerve fiber.
It is appreciated that implanted electric pulse stimulation system provided by the invention can be pacemaker, defibrillator, brain depth
Portion's egersimeter, spinal stimulator, vagus nerve stimulator, stomach stimulator, muscle stimulator, peripheral nerve stimulation device or
Other similar stimulators.The embodiment of the present invention is only illustrated by taking implanted lesions located in deep brain device as an example.
Fig. 1-2 is referred to, the embodiment of the present invention provides an implanted lesions located in deep brain device 10 comprising:One implantation skin
Under impulse generator 11, the stimulating electrode 12 of the deep brain position of an implantation, one connects the stimulating electrode 12 and impulse generator 11
Extension lead 13 and one be used for the program-controlled impulse generator 11 vitro program controlled instrument 14.
The impulse generator 11 generates specific electric stimulation pulse signal 15, and passes through the extension lead 13 and stimulation
Electrode 12 is conducted to stimulation location and carries out stimulation regulation and control.The vitro program controlled instrument 14 can wirelessly connect with the impulse generator 11
It connects, and changes its electric pulse stimulation parameter.
12 tip of the stimulating electrode have multiple contacts, and by stimulating electrode 12 be implanted into target position after, at least one
A contact contacts closely with stimulation target spot, and electro photoluminescence appropriate is conducted to target spot, the disease of neural class is treated.It can manage
Solution, the stimulating electrode 12 are needed to be one or more according to stimulation, be stimulated corresponding position, to ensure to pierce
Swash effect.It is appreciated that the number of the stimulating electrode 12 is not limited to one, can select as needed.
It is appreciated that the extension lead 13 is an optional element, the stimulating electrode 12 can be directly connected to the arteries and veins
It rushes on generator 11.When larger only at a distance from after the stimulating electrode 12 implants with the impulse generator 11, just need
It to be connected by extension lead 13.
11 inside of the impulse generator includes:One microprocessor module 111, a power module 112 and a wireless telecommunications
Module 113.It is electrically connected between the microprocessor module 111, power module 112 and wireless communication module 113.Micro- place
Reason device module 111 has the program editted, can generate different frequency, different pulse widths, different amplitudes electric stimulation pulse
Signal 15.The stimulus waveform of the electric stimulation pulse signal 15 is including but not limited to square wave, sine wave, exponential wave, triangular wave.Separately
Outside, the wireless communication module 113 and the vitro program controlled instrument 14 are wirelessly connected, to can be with by the vitro program controlled instrument 14
The program of the microprocessor module 111 is selected, program parameter is adjusted, to change the electric stimulation pulse signal 15 of output.Institute
It may include the constant frequency stimulation control module and a use for generating constant frequency stimulation pulse signal to state microprocessor module 111
Control module is stimulated in the frequency conversion for generating frequency conversion stimulation pulse signal.However, the microprocessor module 111 includes at least frequency conversion
Stimulate control module.The constant frequency stimulation control module and frequency conversion stimulation control module are to store the integrated electricity of certain procedures
Road, structure is unlimited, and those skilled in the art can design as needed.It is appreciated that constant frequency stimulation control module and
Frequency conversion stimulation control module can be integrated into same module.
Fig. 3 is referred to, the stimulus waveform for the electric stimulation pulse signal 15 that the impulse generator 11 generates can be common
Constant frequency stimulation pulse signal, or frequency conversion stimulation pulse signal.However, the impulse generator 11 can at least generate
Frequency conversion stimulation pulse signal.
Fig. 4-6 is referred to, the frequency conversion stimulation pulse signal 150 includes the electric stimulation pulse string of at least two different frequencies
152 alternating stimulations form multiple burst periods 151, and the electric stimulation pulse string 152 of each frequency is in each burst periods
Duration is 0.1 second~60 minutes in 151.If be appreciated that the electric stimulation pulse string 152 of each frequency it is lasting when
Between it is too short, for example, being less than 0.1 second, then the pulsewidth size of stimulation time and single pulse exists together an order of magnitude, different frequency
Pulse is closely coupled, and effect has prodigious uncontrollability.And if 152 duration of electric stimulation pulse string of each frequency
Too long, for example, being more than 60 minutes, patient can generate single-frequency adaptation, and stimulation for a long time is easy that patient is made to generate stimulation
Adaptability, the similar drug resistance generated to drug, effect are stimulated similar to constant frequency.
Preferably, the electric stimulation pulse string 152 of each frequency duration in each burst periods 151 can be
0.1 second~30 minutes.Preferably, the electric stimulation pulse string 152 of each frequency duration in each burst periods 151
It is 3 seconds~60 seconds.It is highly preferred that the electric stimulation pulse string 152 of each frequency duration in each burst periods 151
It is 5 seconds~30 seconds.Within this period, it both can guarantee that included frequency can generate sufficient effect to target cell,
It can prevent patient from generating adaptability to the stimulation of certain frequency again.
The frequency of the electric stimulation pulse string 152 is less than or equal to 400 hertz, such as 10 hertz~400 hertz.Preferably,
The frequency of the electric stimulation pulse string 152 is 30 hertz~250 hertz.It is highly preferred that the frequency of the electric stimulation pulse string 152
It is 50 hertz~150 hertz.It is in confused situation aobvious to the motor symptoms improvement of patient when frequency of stimulation is less than 30 hertz, more
Even its motor symptoms is made to deteriorate when low frequency.Constant frequency frequency of stimulation used in clinic is relatively good in 100 hertz effects, institute
With preferably 50 hertz~150 hertz of field stimulation, under the premise of ensureing to chief complaint effect or improving cardinal symptom,
Subsidiary symptom is improved simultaneously.
The average value of the electric stimulation pulse string 152 of the different frequency is 60 hertz~180 hertz, preferably, 80 hertz
~120 hertz.The geometrical mean of the electric stimulation pulse string 152 of the different frequency is 60 hertz~180 hertz, preferably,
80 hertz~120 hertz.
From the point of view of clinical data, the high frequency stimulation between 90 hertz~400 hertz is conducive to disturbances in patients with Parkinson disease cardinal symptom
Improvement, 10~90 hertz of stimulation is conducive to dysarthrosis and the improvement for the subsidiary symptoms such as gait is freezed.
The number of the electric stimulation pulse string 152 of the different frequency is N, and N >=2.In general, 2≤N<10.Preferably, 2≤
N≤5.It is highly preferred that the number of the electric stimulation pulse string 152 of the different frequency is 2 or 3.It is appreciated that excessive frequency number
Mesh makes adjustment process more complicated in implementation process, can be by first using the impulse stimulation of a small amount of different frequency to patient
Regulated and controled, determine whether patient adapts to this stimulation mode, and determines whether to improve towards more preferably direction.Further according to trouble
The reaction of person, the appropriate quantity for increasing different frequency, optimizes effect of stimulation.
Time ratio of the electric stimulation pulse string 152 of the different frequency in each burst periods 151 is more than 5%.It is excellent
Selection of land, the time ratio of the electric stimulation pulse string 152 of the different frequency in each burst periods 151 are more than 10%.It is more excellent
Selection of land, the time ratio of the electric stimulation pulse string 152 of the different frequency in each burst periods 151 are more than 30%.Because
The pulse characteristics of different frequency may correspond to different symptoms, control its accounting 5% or more, to ensure the regulation and control to the symptom
Effect.When the number of the electric stimulation pulse string 152 of the different frequency be 2 when or 3, it is preferable that the different frequency electricity thorn
It is 1/N to swash time ratio of the train of pulse 152 in each burst periods 151, wherein N is the electro photoluminescence arteries and veins of the different frequency
The number of punching string 152.For example, when the number of the electric stimulation pulse string 152 of the different frequency is 2, the different frequency
Time ratio of the electric stimulation pulse string 152 in each burst periods 151 is 50%.
The electric stimulation pulse string 152 of the different frequency in each burst periods 151 appearance sequence can be from
Low frequency is to high frequency, from high frequency to low frequency, can also occur with certain random manner, as long as ensuring in the same burst periods
In 151, the time scale shared by each electric stimulation pulse string 152 is certain.
The electric stimulation pulse string 152 of the different frequency can be current-mode or voltage mode.The electric stimulation pulse
The frequency and amplitude of string 152 are adjustable simultaneously.According to current-mode, current amplitude size is 0 milliampere~30 milliamperes adjustable, is adjusted
Precision is 0.1 milliampere.According to voltage mode, voltage magnitude size is 0 volt~15 volts adjustable, and degree of regulation is 0.1 volt.Into
One step, the frequency and pulse width of the electric stimulation pulse string 152 are adjustable simultaneously, and pulse width is the microsecond of 0 microsecond~1000
It is adjustable.
Specifically, Fig. 4 is referred to, the first frequency conversion stimulation pulse signal 150 provided by the invention includes two kinds of different frequencies
Alternately stimulation forms multiple burst periods 151, and the electric stimulation pulse string 152 of each frequency to the electric stimulation pulse string 152 of rate
Time accounting is identical.Fig. 5 is referred to, second of frequency conversion stimulation pulse signal 150 provided by the invention includes two kinds of different frequencies
Electric stimulation pulse string 152 alternately stimulation forms multiple burst periods 151, and when the electric stimulation pulse string 152 of each frequency
Between accounting it is different.Fig. 6 is referred to, the first frequency conversion stimulation pulse signal 150 provided by the invention includes three kinds of different frequencies
Alternately stimulation forms multiple burst periods 151, and 152 time of electric stimulation pulse string of each frequency to electric stimulation pulse string 152
Accounting is different.
Refer to Fig. 7-8, it will be understood that the electric stimulation pulse string 152 of different frequency can continuously occur, and can also be interrupted
Occur.That is, can be with separated in time between the electric stimulation pulse string 152 of two neighboring different frequency.The multiple train of pulse
Period 151 can continuously occur, and can also be interrupted appearance.That is, can also be spaced between two neighboring burst periods 151 certain
Time.Time interval 154 between the electric stimulation pulse string 152 of the two neighboring different frequency and two neighboring train of pulse
Time interval 154 between period 151 can be 0.01 second~60 minutes.Preferably, the electricity of the two neighboring different frequency
The time interval 154 between time interval 154 and two neighboring burst periods 151 between boost pulse string 152 can be with
It is 0.01 second~60 seconds.In one embodiment, which is T/N, wherein T is the cycle of a burst periods 151
Time, N are the number of the electric stimulation pulse string 152 of different frequency.Technical ability in this way ensures the validity of interval time, and can guarantee
Interval time is unlikely to too big, prevents excessive time interval from causing stimulation invalid.
Further, the electric stimulation pulse string 152 of a variety of experience frequency of stimulation can also be stored in the impulse generator 11
Combination is suitable for regular situation.The experience frequency of stimulation electric stimulation pulse string 152 combination can be 50 hertz with 150 hertz,
60 hertz and 140 hertz, 70 hertz and 130 hertz, 80 hertz and 120 hertz, 90 hertz and 110 hertz, and each frequency
The time accounting of electric stimulation pulse string 152 is 50%.The different frequencies that the electric stimulation pulse string 152 of the experience frequency of stimulation combines
The average value of rate is identical.It is appreciated that the stimulated current value of a variety of experiences, example can also be stored in the impulse generator 11
Such as:0.5 milliampere, 1 milliampere, 1.5 milliamperes, 2 milliamperes, 2.5 milliamperes.The stimulated current value can be with above-mentioned electric stimulation pulse string 152
Combination is used cooperatively.
In use, different electric stimulation pulse strings 152 can be selected to combine and stimulated current value as needed.For example,
Under normal operating conditions, replace stimulation with 120 hertz using 80 hertz, each time accounting is 50%, stimulated current size
It is 2 milliamperes.Alternatively, for the lighter patient of the state of an illness, replace stimulation with 120 hertz using 80 hertz, each time accounting is
50%, stimulated current size is 1.5 milliamperes.
Further, the impulse generator 11 has the function of frequency sweep.The impulse generator is set by vitro program controlled instrument 14
After 11 sweep parameters, which can carry out frequency sweep according to the parameter.The impulse generator 11 introduced below
Different frequency sweep modes.
The first frequency sweep mode is single-frequency frequency sweep.In the single-frequency frequency sweep mode, when set swept frequency range as
F1min~F1max, frequency sweep precision be S1, sweep time T1, the impulse generator 11 will with F1min, F1min+S1,
F1min+2S1, F1min+3S1 ... F1min+nS1 and F1max export an electric stimulation pulse string 152, and each electricity thorn respectively
The duration for swashing train of pulse 152 is T1, wherein n is natural number, and n≤(F1max-F1min)/S1.The swept frequency range
F1min~F1max can be selected between 0 hertz~380 hertz.The frequency sweep precision S1 can be 1 hertz~10 hertz can
It adjusts, it is adjustable preferably by 2 hertz~5 hertz.The sweep time T1 can be 5 seconds~60 minutes adjustable, preferably by
10 seconds~30 minutes adjustable.For example, setting swept frequency range as 50 hertz~150 hertz, 10 hertz of frequency sweep precision, single-frequency is swept
Retouch the time 10 seconds.The impulse generator 11 will be respectively with 50 hertz, 60 hertz, 70 hertz, 80 hertz, 90 hertz, 100 hertz
Hereby, 110 hertz, 120 hertz, 130 hertz, 140 hertz and 150 hertz export an electric stimulation pulse string 152 respectively, and each
Electric stimulation pulse string 152 is for 10 seconds.Fig. 9 is referred to, is the first frequency sweep of impulse generator provided in an embodiment of the present invention
The frequency-time relational graph of the electric stimulation pulse signal of pattern, wherein n=4.
Second of frequency sweep mode is that multi-frequency replaces progressive frequency sweep.The multi-frequency replaces in progressive frequency sweep mode, works as setting
Swept frequency range is F2min~F2max, and frequency sweep precision is S2, sweep time T2, the impulse generator 11 will with F2min and
F2max, F2min+S2 and F2max-S2, F2min+2S2 and F2max-2S2 ... and F2min+nS2 and F2max-nS2 are handed over respectively
For two electric stimulation pulse strings 152 of output, and the duration that each two electric stimulation pulse string 152 alternately exports is T2, wherein
N is natural number, and n<(F2max-F2min)/2S2.It is appreciated that the sweep time T2 should be each burst periods 151
Duration integral multiple.Swept frequency range F2min~the F2max can be selected between 0 hertz~380 hertz.It is described
Frequency sweep precision S2 can be 1 hertz~10 hertz adjustable, adjustable preferably by 2 hertz~5 hertz.The sweep time T2 can
Think 5 seconds~60 minutes it is adjustable, it is adjustable preferably by 30 seconds~10 minutes.For example, setting swept frequency range as 50 hertz~150
Hertz, 10 hertz of frequency sweep precision, sweep time T2 is 30 seconds, and the duration of the burst periods 151 is 2 seconds, and each
152 duration of electric stimulation pulse string is 1 second.The impulse generator 11 will be with 50 hertz and 150 hertz, 60 hertz and 140
Hertz, 70 hertz replace respectively with 110 hertz with 120 hertz and 90 hertz with 130 hertz, 80 hertz and export two electric thorns
Train of pulse 152 is swashed to form 15 burst periods 151.Figure 10 is referred to, is pulse generation provided in an embodiment of the present invention
The frequency-time relational graph of the electric stimulation pulse signal of second of frequency sweep mode of device, wherein n=2.
The third frequency sweep mode is multi-frequency alternate combinations frequency sweep.In the multi-frequency alternate combinations frequency sweep mode, work as setting
Reference frequency is Fb1 and Fb2, and swept frequency range F3, frequency sweep precision is S3, and sweep time T3, the impulse generator 11 will
Respectively with Fb1 and Fb2, Fb1+S3 and Fb2, Fb1+2S3 and Fb2 ... Fb1+nS3 and Fb2, Fb1-S3 and Fb2, Fb1-2S3 and
Fb2 ... Fb1-nS3 and Fb2, Fb1 and Fb2+S3, Fb1 and Fb2+2S3 ... Fb1 and Fb2+nS3, Fb1 and Fb2-S3, Fb1 and
Fb2-2S3 ... Fb1 and Fb2-nS3 alternately export two electric stimulation pulse strings 152, and each two electric stimulation pulse string 152 replaces
The duration of output is T3, wherein n is natural number, and n=F3/S3.It is appreciated that the sweep time T3 should be each
The integral multiple of the duration of burst periods 151, and swept frequency range is the integral multiple that F3 is frequency sweep precision S3.The benchmark frequency
Rate, which is Fb1 and Fb2, to be selected according to actual needs, and the usual reference frequency is Fb1 and Fb2 at 60 hertz~120 hertz
Between.The swept frequency range F3 can be selected between 1 hertz~20 hertz, and preferably F3 is selected between 5 hertz~10 hertz
It selects.The frequency sweep precision S3 can be 1 hertz~10 hertz adjustable, adjustable preferably by 2 hertz~5 hertz.The scanning
Time T3 can be 5 seconds~60 minutes adjustable, adjustable preferably by 30 seconds~10 minutes.For example, setting reference frequency as 80
Hertz is 10 hertz with 100 hertz, swept frequency range, 5 hertz of frequency sweep precision, per the 1 minute time of class frequency combined and alternatively scanning,
The duration of each burst periods 151 is 3 seconds, and two electric stimulation pulse strings 152 in each burst periods 151 are held
The continuous time is respectively 1 second and 2 seconds.The impulse generator 11 will with 80 hertz and 100 hertz, 85 hertz and 100 hertz, 90 hertz
Hereby with 100 hertz, 75 hertz and 100 hertz, 70 hertz and 100 hertz, 80 hertz and 105 hertz, 80 hertz and 110 hertz,
80 hertz and 95 hertz, 80 hertz and 90 hertz alternately export two electric stimulation pulse strings 152 to form 20 pulses respectively
It goes here and there the period 151.Figure 11 is referred to, is the electro photoluminescence arteries and veins of the third frequency sweep mode of impulse generator provided in an embodiment of the present invention
Rush the frequency-time relational graph of signal, wherein F3=S3.
4th kind of frequency sweep mode is also multi-frequency alternate combinations frequency sweep.In the multi-frequency alternate combinations frequency sweep mode, when setting
It is Fb1 and Fb2 to determine reference frequency, and swept frequency range F3, frequency sweep precision is S3, sweep time T3, the impulse generator 11
Will respectively with Fb1 and Fb2, Fb1+S3 and Fb2+S3, Fb1+2S3 and Fb2+2S3 ... Fb1+nS3 and Fb2+nS3, Fb1-S3 and
Fb2-S3, Fb1-2S3 and Fb2-2S3 ... Fb1-nS3 and Fb2-nS3, Fb1+S3 and Fb2-S3, Fb1+2S3 and Fb2-2S3 ...
Fb1+nS3 and Fb2-nS3, Fb1-S3 and Fb2+S3, Fb1-2S3 and Fb2+2S3 ... Fb1-nS3 and Fb2+nS3 alternately outputs two
A electric stimulation pulse string 152, and the duration that each two electric stimulation pulse string 152 alternately exports is T3, wherein n is nature
Number, and n=F3/S3.It is appreciated that the 4th kind of frequency sweep mode and the third above-mentioned frequency sweep mode are essentially identical, difference
For:In the third frequency sweep mode, when a variation in Fb1 and Fb2, another is remained unchanged;And the 4th kind of frequency sweep mode
In, when a variation in Fb1 and Fb2, another can also change.For example, setting reference frequency as 80 hertz and 105 hertz
Hereby, swept frequency range is 10 hertz, 5 hertz of frequency sweep precision, per the 1 minute time of class frequency combined and alternatively scanning, each train of pulse
The duration in period 151 is 3 seconds, and two 152 duration of electric stimulation pulse string difference in each burst periods 151
For 2 seconds and 1 second.The impulse generator 11 will be with 80 hertz and 105 hertz, 85 hertz and 110 hertz, 90 hertz and 115 hertz
Hereby, 75 hertz and 100 hertz, 70 hertz and 95 hertz, 85 hertz and 100 hertz, 90 hertz and 95 hertz, 75 hertz and 110
Hertz, 70 hertz and 115 hertz alternately export two electric stimulation pulse strings 152 to form 20 burst periods 151 respectively.
Figure 12 is referred to, is the frequency of the electric stimulation pulse signal of the 4th kind of frequency sweep mode of impulse generator provided in an embodiment of the present invention
Rate-time chart, wherein F3=S3.
Figure 13-14 is referred to, the embodiment of the present invention further provides for electric pulse stimulation test system 20 comprising:One
Testing in vitro stimulator 21, a test cable 22, a test lead 23 and a stimulating electrode 12.Wherein, present invention definition should
Testing in vitro stimulator 21, test cable 22 and test lead 23 are electric pulse stimulation test device.
In use, stimulating electrode 12 is implanted, by one end of the test lead 23 by the test cable 22 with
The testing in vitro stimulator 21 is electrically connected, and the other end is electrically connected with the stimulating electrode 12 that one implants.The testing in vitro
Stimulator 21 generates specific electric stimulation pulse signal 15, and passes through the test cable 22, test lead 23 and stimulation electricity
Pole 12 is conducted to stimulation location and carries out stimulation regulation and control.If patient is suitble to electronic stimulation, the stimulating electrode to implant
12 without taking out.
It is appreciated that the test cable 22 is an optional element, the test lead 23 can also be directly connected to this
On testing in vitro stimulator 21.The test cable 22 is prepared without biocompatible materials.
The both ends of the test lead 23 are respectively equipped with connector, so as to real with the test cable 22 or stimulating electrode 12
Now it is electrically connected.Due to the use of when the test lead 23 can in partial insertion organism, therefore, the test lead 23 at least with
The part that stimulating electrode 12 connects is prepared using biocompatible materials.Preferably, the test lead 23 is all using biology
It is prepared by compatibility material.
The testing in vitro stimulator 21 includes an external pulse generating module 210.The pulse generating module 210 with it is upper
It is identical to state 11 structure of above-mentioned impulse generator.Specifically, the pulse generating module 210 includes a microprocessor module 211, one
Power module 212 and a control module 213.The microprocessor module 211, power module 212 and control module 213 it
Between be electrically connected.The microprocessor module 211 has the program editted, can generate different frequency, distinct pulse widths, different width
The electric stimulation pulse signal 15 of value.The control module 213 includes display, input keyboard etc..Pass through the control module 213
The program of the microprocessor module 211 can be selected, program parameter is adjusted, to change the electric stimulation pulse signal of output
15.Since the external pulse generating module 210 is without implanting, prepared without biocompatible materials.
Fig. 3-8 is referred to, the pulse generating module 210 also can at least generate the change of the generation of above-mentioned impulse generator 11
Frequency stimulation pulse signal.Further, Fig. 9-12 is referred to, the pulse generating module 210 also has above-mentioned impulse generator 11
Frequency sweep function.The electric pulse stimulation test system 10 of the present invention can be used for testing by introducing frequency conversion stimulation pulse signal
Patient is treated if appropriate for using frequency conversion stimulation pulse signal.
The present invention further provides a kind of method stimulated target nerve using above-mentioned frequency conversion stimulation pulse signal,
This method includes:
Step S10 determines the frequency of stimulation of the frequency conversion stimulation pulse signal;And
The frequency conversion stimulation pulse signal is acted on target nerve by step S20.
In the step S10, method that the present invention provides the frequency of stimulation of two kinds of determination frequency conversion stimulation pulse signals.
Method one, for having used constant frequency to stimulate one period, and the patient of some subsidiary ill symptoms.First remember
Record the primary frequency A that the patient uses constant frequency stimulation.In general, different patients are made using the normal of constant frequency stimulation
It is determining value with frequency.Then, the impulse generator 11 of patient is controlled using vitro program controlled instrument 14, is allowed to export constant
The reflection of patient is observed in the pulse of frequency.If patient's subsidiary symptom under a certain frequency is improved, the pulse frequency is recorded
B.According to formula:C=A2The frequency C that a correspondence uses is calculated in/B.That is, the frequency C that the correspondence uses is obtained with subsidiary symptom
Geometrical mean to improved frequency B is primary frequency A.The frequency B and frequency C is the frequency conversion boost pulse
The frequency of stimulation of signal.
It, can be respectively according to the above method and public affairs if being appreciated that two or more subsidiary subsidiary symptom of patient
Formula obtains corresponding frequency C, D etc. used.Described frequency B, C, D etc. are the frequency of stimulation of the frequency conversion stimulation pulse signal.
Method two, this method two and method one are essentially identical, the difference is that, according to formula:A pair is calculated in C=2A-B
The frequency C that should be used.That is, the arithmetic mean of instantaneous value for the frequency B that the frequency C that the correspondence uses is improved with subsidiary symptom is just
It is often used frequency A.
Method three, for the patient for using electric pulse stimulation to be treated for the first time.Using vitro program controlled instrument 14 to patient's
Impulse generator 11 is controlled, and the impulse generator 11 is made to carry out frequency sweep according to the first above-mentioned single-frequency frequency sweep mode,
The pulse signal of different constant frequencies is exported, and record makes the pulse frequency B and C that patient's different symptoms are improved respectively.
The frequency B and frequency C is the frequency of stimulation of the frequency conversion stimulation pulse signal.Stimulation is carried out using constant frequency stimulation and finds patient
The pulse frequency that symptom is improved requires a very short time, usually more than ten seconds to a few minutes.
If being appreciated that there are three types of patient's trouble or three kinds with different symptoms, patient's different symptoms are recorded respectively and are obtained
Improved pulse frequency B, C, D ....Described frequency B, C, D etc. are the frequency of stimulation of the frequency conversion stimulation pulse signal.
Further, the frequency of stimulation B and C of the alternating stimulation pulse signal obtained using the above method to the stimulation of patient simultaneously
Non- is optimal.The present invention can on the basis of B and C frequency, pass through the pattern of the third above-mentioned multi-frequency alternate combinations frequency sweep
Frequency sweep is carried out, to obtain optimal frequency of stimulation B and C.
In the step S20, the time ratio of the electric stimulation pulse of different frequency can be first set as 1/N, wherein N is institute
State the number of the electric stimulation pulse of different frequency.It is appreciated that can be according to actual needs to the frequency conversion stimulation pulse signal
Parameter is mediated.For example, if some symptom improves unobvious, it is corresponding increase frequency of stimulation corresponding with the symptom when
Between accounting, reduce the time accounting of the corresponding frequency of stimulation of other symptoms, reach balanced until making the symptom of patient improve.
In existing stimulus modality, stimulus waveform, which is the constant frequency of upper frequency, to stimulate, and the constant frequency is to patient
Symptom have an improvement, but be inevitably attached to some ill symptoms, and patient be easy to generate the stimulation of this constant frequency it is suitable
Ying Xing.The present invention is by introducing frequency conversion stimulation pulse signal, under the premise of ensureing to the effect of stimulation of patient, can improve or
Eliminate subsidiary symptom.
For example, in clinic, disturbances in patients with Parkinson disease implantation brain pacemaker stimulates its subthalamic nuclei, can significantly improve it
It trembles, the symptoms such as body is stiff.However, in the prior art, the stimulation to subthalamic nuclei is the stimulation of constant frequency.For a long time
Stimulation after, some patientss will produce gait freeze, dysarthrosis, the subsidiary symptom such as unusual fluctuation.In addition, long-time single-frequency
Stimulation, such as 100 hertz make patient be easy to generate adaptability to this stimulation, are similar to adaptability of the patient to drug, stimulation effect
Fruit is deteriorated.
In some clinical cases, frequency conversion stimulus modality is for treating disturbances in patients with Parkinson disease.It is clinical research shows that variable-frequency electric
Stimulation can improve Parkinson motor symptoms, such as tremble or/and body be stiff, while improve Parkinson non-athletic disease
Shape, if gait is freezed, dysarthrosis is mobile etc., and can avoid adaptability caused by constant frequency.In addition, studies have shown that the change
Frequency stimulating system for move relevant Other diseases such as myodystony, and with cognition, the relevant neurogenic disease of psychology
Such as depression, habituation, there is fine curative effect.
The present invention has been used to improve disturbances in patients with Parkinson disease due to subsidiary symptom and adaptation caused by long term constant frequency stimulation
Property.It is the real case of the application present invention below.
Case 1
Disturbances in patients with Parkinson disease X generates dysarthric symptom after the stimulation of prolonged 130 hertz of constant frequencies.The patient X's
Primary frequency A is 130 hertz.
The impulse generator 11 of patient X is controlled using vitro program controlled instrument 14, is allowed to export the pulse of constant frequency,
Observe the reflection of patient X.Patient X under the stimulation of 60Hz, the state of dysarthrosis be improved significantly.Using 60 hertz and
130 hertz of frequency conversion stimulation pulse signal carries out stimulation therapy to patient X.The time accounting for setting two kinds of frequencies is 50%,
The electric stimulation pulse string of each frequency duration in each burst periods is 10 seconds.Through stimulation after a period of time,
The improvement degree of the symptom of patient X is observed, the situation of dysarthrosis is significantly improved.Frequency conversion stimulation through the invention,
Under the premise of ensureing therapeutic effect, the minute symptom of patient is improved.It is patient below to be stimulated and become with common constant frequency
Stimulate obtained sounding effect to compare frequently.
1 constant frequency of table stimulates the phonation efficiency with frequency conversion stimulation to compare
Case 2
Disturbances in patients with Parkinson disease Y freezes symptom with body rigidity symptom and gait, and is controlled for the first time using electric pulse stimulation
It treats.
Different constant frequency frequency of stimulation is selected according to the symptom of patient Y, finds the patient Y under 130 hertz of constant frequency stimulation
Body rigidity symptom be significantly improved, and the gait of patient Y freezes symptom and obtains one under the stimulation of 80 hertz of constant frequency
It is fixed to improve.
Stimulation therapy is carried out to patient Y using 130 hertz and 80 hertz of frequency conversion stimulation pulse signals.Set two kinds of frequencies
Time accounting be 50%, the electric stimulation pulse string of each frequency duration in each burst periods is 20 seconds.
The improvement situation of patient symptom is observed, it is found that gait is freezed to be significantly improved, but body rigidity improvement is undesirable.Into one
Step, it is 60% to adjust 130 hertz frequency accountings, and 80 hertz frequency accountings are 40%, then observe the improvement situation of patient, find step
State is freezed to be significantly improved with body rigidity.
Case 3
Disturbances in patients with Parkinson disease Z cardinal symptom body rigidities, while thering is serious gait to freeze symptom.
Apply left side frequency 130Hz, amplitude 2.7V, 60 μ s of pulse width to patient Z;Right side frequency 130Hz, amplitude
1.7V, the permanent frequency stimulation of 60 μ s of pulse width, stiff symptom be improved significantly, gait freezes exacerbation of symptoms.By patient
Frequency of stimulation be reduced to 60Hz, i.e. left side frequency 60Hz, amplitude 2.7V, 60 μ s of pulse width;Right side frequency 60Hz, amplitude
The constant frequency of 1.7V, 60 μ s of pulse width stimulate, which, which freezes symptom, improves obviously, but stiff symptom deteriorates.It is adjusted to
The Frequency of 60&130Hz stimulates, i.e. left side frequency 60&130Hz, amplitude 2.7V, 60 μ s of pulse width;Right side frequency 60&
130Hz, amplitude 2.7V, pulse width 60 μ s, one of them period 50s, including the 60Hz stimulations of 20s and the 130Hz of 30s are pierced
Swash.The spasticity of patient be improved significantly, and gait freeze symptom be improved significantly.It is before patient's frequency conversion stimulates below
Gait evaluation table afterwards.
The front and back gait evaluation comparison of 2 frequency conversion of table stimulation
From upper table, it can be seen that, frequency conversion stimulation is stimulated compared to constant frequency, and patient's start-up time, the turning dead time obviously subtracts
It is few, gait freeze be improved significantly.
In addition, those skilled in the art can also do other variations in spirit of that invention, these are spiritual according to the present invention
The variation done should be all included in scope of the present invention.
Claims (14)
1. a kind of electric pulse stimulation test device is practically applicable to that constant frequency has been used to stimulate one period and subsidiary bad disease
The patient of shape comprising:One testing in vitro stimulator and a test lead, and the testing in vitro stimulator is sent out including a pulse
Raw module, the pulse generating module at least generate frequency conversion stimulation pulse signal, which includes at least two
The electric stimulation pulse string of kind different frequency, alternately stimulation forms multiple burst periods, and each frequency to the electric stimulation pulse string
The electric stimulation pulse string of rate duration in each burst periods is 0.1 second~60 minutes;It is characterized in that, the frequency conversion
The frequency of stimulation of stimulation pulse signal is determined by following steps:
Record the primary frequency A that the patient uses constant frequency stimulation;
Make the impulse stimulation patient of pulse generating module output constant frequency, and records the patient and be attached to ill symptoms and changed
Kind pulse frequency B;And
According to formula C=A2It is frequency conversion stimulation arteries and veins that the frequency C, the frequency B and frequency C that a correspondence uses, which is calculated, in/B
Rush the frequency of stimulation of signal.
2. electric pulse stimulation test device as described in claim 1, which is characterized in that the electric stimulation pulse string of each frequency exists
Duration is 0.1 second~30 minutes in each burst periods.
3. electric pulse stimulation test device as described in claim 1, which is characterized in that the frequency of the electric stimulation pulse string is
10 hertz~400 hertz.
4. electric pulse stimulation test device as described in claim 1, which is characterized in that the electric stimulation pulse of the different frequency
The number of string is N, and 2≤N<10, and time ratio of the electric stimulation pulse string of the different frequency in each burst periods
More than 5%.
5. electric pulse stimulation test device as described in claim 1, which is characterized in that the electric stimulation pulse of the different frequency
Separated in time between string, and the time interval between the electric stimulation pulse string of two neighboring different frequency is 0.01 second~60
Minute;Or separated in time between the multiple burst periods, and the time interval between two neighboring burst periods
It is 0.01 second~60 minutes.
6. electric pulse stimulation test device as described in claim 1, which is characterized in that electro photoluminescence arteries and veins in each burst periods
The appearance sequence of string is rushed from small to large, or from big to small or random to occur by frequency.
7. electric pulse stimulation test device as described in claim 1, which is characterized in that the frequency of the electric stimulation pulse string and
Amplitude is adjustable simultaneously;Or the frequency and pulse width of the electric stimulation pulse string are adjustable simultaneously.
8. electric pulse stimulation test device as claimed in claim 2, which is characterized in that the electric stimulation pulse string of each frequency exists
Duration is 3 seconds~60 seconds in each burst periods.
9. electric pulse stimulation test device as claimed in claim 8, which is characterized in that the electric stimulation pulse string of each frequency exists
Duration is 5 seconds~30 seconds in each burst periods.
10. electric pulse stimulation test device as claimed in claim 3, which is characterized in that the frequency of the electric stimulation pulse string
It is 30 hertz~250 hertz.
11. electric pulse stimulation test device as claimed in claim 10, which is characterized in that the frequency of the electric stimulation pulse string
It is 50 hertz~150 hertz.
12. a kind of electric pulse stimulation test device is practically applicable to that constant frequency has been used to stimulate one period and is attached to bad
The patient of symptom comprising:One testing in vitro stimulator and a test lead, and the testing in vitro stimulator includes a pulse
Module occurs, the pulse generating module at least generates frequency conversion stimulation pulse signal;It is characterized in that, the frequency conversion boost pulse is believed
Number frequency of stimulation determined by following steps:
Record the primary frequency A that the patient uses constant frequency stimulation;
Make the impulse stimulation patient of pulse generating module output constant frequency, and records the patient and be attached to ill symptoms and changed
Kind pulse frequency B;And
According to formula C=A2It is frequency conversion stimulation arteries and veins that the frequency C, the frequency B and frequency C that a correspondence uses, which is calculated, in/B
Rush the frequency of stimulation of signal.
13. a kind of electric pulse stimulation test device is practically applicable to that constant frequency has been used to stimulate one period and is attached to bad
The patient of symptom comprising:One testing in vitro stimulator and a test lead, and the testing in vitro stimulator includes a pulse
Module occurs, the pulse generating module at least generates frequency conversion stimulation pulse signal, which only includes three
The electric stimulation pulse string of kind different frequency, alternately stimulation forms multiple burst periods to the electric stimulation pulse string;Its feature exists
In the frequency of stimulation of the frequency conversion stimulation pulse signal is determined by following steps:
Record the primary frequency A that the patient uses constant frequency stimulation;
Make the impulse stimulation of the pulse generating module output constant frequency patient, and it is two different subsidiary bad to record the patient
The pulse frequency B that symptom is improved1And B2;And
According to formula C=A2/B1The frequency C that a correspondence uses is calculated, according to formula D=A2/B2Another pair is calculated to answer
The frequency D, described frequency B, C, D used is the frequency of stimulation of the frequency conversion stimulation pulse signal.
14. a kind of electric pulse stimulation tests system comprising:One electric pulse stimulation test device and a stimulating electrode, it is special
Sign is that the electric pulse stimulation test device is in the electric pulse stimulation test device as described in the claims 1 to 13
Any one.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410849257.4A CN104548349A (en) | 2014-12-31 | 2014-12-31 | Electric pulse stimulation testing device and testing system with electric pulse stimulation testing device |
CN2014108492574 | 2014-12-31 | ||
CN201510211704.8A CN105079963B (en) | 2014-12-31 | 2015-04-29 | A kind of electric pulse stimulation is tested device and uses the test system of this device |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510211704.8A Division CN105079963B (en) | 2014-12-31 | 2015-04-29 | A kind of electric pulse stimulation is tested device and uses the test system of this device |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106139399A CN106139399A (en) | 2016-11-23 |
CN106139399B true CN106139399B (en) | 2018-10-02 |
Family
ID=53066092
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410849257.4A Pending CN104548349A (en) | 2014-12-31 | 2014-12-31 | Electric pulse stimulation testing device and testing system with electric pulse stimulation testing device |
CN201510211704.8A Active CN105079963B (en) | 2014-12-31 | 2015-04-29 | A kind of electric pulse stimulation is tested device and uses the test system of this device |
CN201610632499.7A Active CN106039555B (en) | 2014-12-31 | 2015-04-29 | A kind of electric pulse stimulation test device and the test macro using the device |
CN201610628233.5A Active CN106267561B (en) | 2014-12-31 | 2015-04-29 | A kind of electric pulse stimulation test device and the test system using the device |
CN201610628487.7A Active CN106139399B (en) | 2014-12-31 | 2015-04-29 | A kind of electric pulse stimulation test device and the test system using the device |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410849257.4A Pending CN104548349A (en) | 2014-12-31 | 2014-12-31 | Electric pulse stimulation testing device and testing system with electric pulse stimulation testing device |
CN201510211704.8A Active CN105079963B (en) | 2014-12-31 | 2015-04-29 | A kind of electric pulse stimulation is tested device and uses the test system of this device |
CN201610632499.7A Active CN106039555B (en) | 2014-12-31 | 2015-04-29 | A kind of electric pulse stimulation test device and the test macro using the device |
CN201610628233.5A Active CN106267561B (en) | 2014-12-31 | 2015-04-29 | A kind of electric pulse stimulation test device and the test system using the device |
Country Status (1)
Country | Link |
---|---|
CN (5) | CN104548349A (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI637765B (en) * | 2016-05-10 | 2018-10-11 | 台灣共振波研發股份有限公司 | Soothing device for attention deficit hyperactivity disorder |
CN107970524A (en) * | 2017-12-01 | 2018-05-01 | 北京品驰医疗设备有限公司 | A kind of testing stimulus device |
CN109011152B (en) * | 2018-08-22 | 2022-03-18 | 创领心律管理医疗器械(上海)有限公司 | Fixing device, testing device and testing method for pacemaker in-vitro test |
CN109064712A (en) * | 2018-09-07 | 2018-12-21 | 重庆医科大学 | A kind of monitoring warning device and method for early warning for the monitoring of the elderly's sleep heart rate |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1061532A (en) * | 1990-11-17 | 1992-06-03 | 荣成市崖头联合企业总公司 | Therapeutic instrument for recovering from amyotrophy |
CN101648053A (en) * | 2009-09-03 | 2010-02-17 | 清华大学 | Double-channel embedded nerve stimulator |
CN102921105A (en) * | 2012-07-13 | 2013-02-13 | 北京品驰医疗设备有限公司 | In-vitro test stimulator |
CN202777459U (en) * | 2012-06-29 | 2013-03-13 | 杨小玉 | Sacral nerve anterior root electrical stimulation system |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN2031694U (en) * | 1988-04-05 | 1989-02-01 | 王志西 | Variable-frequency electronic apparatus for dispelling pain |
US5836994A (en) * | 1997-04-30 | 1998-11-17 | Medtronic, Inc. | Method and apparatus for electrical stimulation of the gastrointestinal tract |
US7024247B2 (en) * | 2001-10-15 | 2006-04-04 | Northstar Neuroscience, Inc. | Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures |
EP2344239B1 (en) * | 2008-09-19 | 2019-11-06 | Terry William Burton Moore | Device for reducing muscle tension through electrical manipulation |
US8825164B2 (en) * | 2010-06-11 | 2014-09-02 | Enteromedics Inc. | Neural modulation devices and methods |
CN102798592B (en) * | 2012-08-20 | 2015-04-15 | 上海交通大学 | Micro-nano driving platform for real-time variable-frequency regulation and control of muscle fiber |
TWI498101B (en) * | 2012-08-30 | 2015-09-01 | Univ Nat Chiao Tung | Method of analyzing nerve fiber distribution and measuring standardized induced compound motion electric potential |
-
2014
- 2014-12-31 CN CN201410849257.4A patent/CN104548349A/en active Pending
-
2015
- 2015-04-29 CN CN201510211704.8A patent/CN105079963B/en active Active
- 2015-04-29 CN CN201610632499.7A patent/CN106039555B/en active Active
- 2015-04-29 CN CN201610628233.5A patent/CN106267561B/en active Active
- 2015-04-29 CN CN201610628487.7A patent/CN106139399B/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1061532A (en) * | 1990-11-17 | 1992-06-03 | 荣成市崖头联合企业总公司 | Therapeutic instrument for recovering from amyotrophy |
CN101648053A (en) * | 2009-09-03 | 2010-02-17 | 清华大学 | Double-channel embedded nerve stimulator |
CN202777459U (en) * | 2012-06-29 | 2013-03-13 | 杨小玉 | Sacral nerve anterior root electrical stimulation system |
CN102921105A (en) * | 2012-07-13 | 2013-02-13 | 北京品驰医疗设备有限公司 | In-vitro test stimulator |
Also Published As
Publication number | Publication date |
---|---|
CN105079963A (en) | 2015-11-25 |
CN106267561B (en) | 2018-10-23 |
CN106267561A (en) | 2017-01-04 |
CN106039555A (en) | 2016-10-26 |
CN106139399A (en) | 2016-11-23 |
CN106039555B (en) | 2019-01-11 |
CN105079963B (en) | 2016-08-17 |
CN104548349A (en) | 2015-04-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN106139398B (en) | A kind of implanted electric pulse stimulation system | |
CN107949421B (en) | System and method for treating urinary dysfunction | |
CN103415318B (en) | Use the neurocardiac treatment of electrical impedance | |
CA2702326C (en) | Neurostimulator and method for regulating the same | |
US8923976B2 (en) | Movement patterns for electrical stimulation therapy | |
CN107278161B (en) | Method and device for nerve inhibition upon activation of brown adipose tissue | |
Cracchiolo et al. | Bioelectronic medicine for the autonomic nervous system: clinical applications and perspectives | |
CN105705195B (en) | System and method for restoring the muscle function of lumbar vertebrae | |
US20210101012A1 (en) | System and method for tactile c-fiber stimulation | |
CN106139399B (en) | A kind of electric pulse stimulation test device and the test system using the device | |
US11712566B2 (en) | Sacral nerve stimulation | |
CN104922794B (en) | A kind of position apparatus for evaluating of testing stimulus electrode | |
CN106730342A (en) | A kind of implanted sacral nerve stimulator with dislocation of electrode prompt facility | |
CN107405485A (en) | Use the method and apparatus of power activation brown adipose tissue | |
Ciotti et al. | A computational model of the pudendal nerve for the bioelectronic treatment of sexual dysfunctions | |
CN207356362U (en) | Implanted extraocular muscle neuromuscular stimulators | |
US11931572B1 (en) | System and method for providing transcutaneous or subcutaneous temporal interference spinal cord stimulation | |
UK | Evidence review: Vagus nerve stimulation: Epilepsies in children, young people and adults: diagnosis and management | |
Shahdoostfard | A Miniaturized Brain-Machine-Spinal Cord Interface (BMSI) for Closed-Loop Intraspinal Microstimulation | |
Senn | Peripheral nerve stimulation for the treatment of chronic neuropathic pain | |
Mohseni | Shahabedin Shahdoostfard | |
CN113663219A (en) | Implantable medical device and pulse generation method thereof | |
Lo | Bioelectronic circuits and systems design for epi-retinal and neural prostheses | |
WO2020061538A1 (en) | Bioelectric blood pressure management | |
Ren et al. | Bionic vision: Current progress and future chanllege |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |