CN106138279A - Pharmaceutical composition for the treatment of rhinitis and preparation method thereof - Google Patents
Pharmaceutical composition for the treatment of rhinitis and preparation method thereof Download PDFInfo
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Abstract
A kind of pharmaceutical composition treating rhinitis, the pharmaceutical composition of described treatment rhinitis is made up of the raw material of following weight: Fructus Xanthii, Flos Magnoliae, Gypsum Fibrosum, Rhizoma Coptidis, Radix Scutellariae, Radix Glycyrrhizae.Through three times dense decoct after take extract, in extract add Mel, obtain after stirring outer be coated with use thick shape medicine juice.The diseases such as the present invention can effectively treat that nasal sinusitis is obstructed, do not hear perfume (or spice) and smells, yellow many, the head nose pain of turbid amount of rhinorrhea with clear discharge, have significant curative effect, without recurrence, have no side effect, and have that composition is simple, production procedure is simple and convenient, easy to use, be prone to the advantages such as storage.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition treating rhinitis, further relate to a kind of pharmaceutical composition preparation method treating rhinitis, belong to the field of Chinese medicines.
Background technology
Rhinitis i.e. nasal cavity inflammatory diseases, is the inflammation of the bronchia mucosal that virus, antibacterial, allergen, various physical and chemical factor and some systemic disease cause.The main pathological change of rhinitis is bronchia mucosal hyperemia, swelling, ooze out, hypertrophy, atrophy or necrosis etc..Common rhinitis includes acute or chronic rhinitis, acute and chronic nasal sinusitis, allergic rhinitis, vasomotor rhinitis, atrophic rhinitis.
The cause of disease suffering from rhinitis substantially can be divided into 4 kinds: 1, virus infects: it is its primary cause of disease that virus infects, or secondary bacterial infection on the basis of virus infects.Known have the virus of kind more than 100 can cause primary disease, is most commonly that rhinovirus, next to that influenza and parainfluenza virus, adenovirus, coronavirus, Coxsackie virus and mucus and paramyxovirus etc..Virus disseminating mode mainly sucks through respiratory tract, next to that enter body by contaminated body or food.2, inherited genetic factors: have allergy family history person to be susceptible to suffer from this sick.Patient home personnel have asthma, urticaria or drug allergy history more.This patient was called atopic individuals in the past, and the ability of its internal generation IgE antibody is higher than normal person.But in recent years it has been found that, twin with general population in sickness rate without significant difference.3, nasal mucosa susceptibility: the generation of susceptibility comes from the frequent stimulation of antigenic substance, but its susceptible degree then regards mastocyte in nasal mucosa, the quantity of basophilic granulocyte and the ability of release chemical mediator.Show it has proven convenient that above-mentioned cell quantity is not only above normal person in allergic rhinitis patients nasal mucosa, and have the ability discharging more by force chemical mediator.4, antigenic substance: the antigenic substance stimulating body to produce IgE antibody is referred to as allergen.This allergenic substances is again introduced into nasal mucosa, just combines with corresponding IgE and causes allergy.The allergen causing primary disease is divided into imbedibility and food two big classes by its mode entering human body.
Following several symptom is substantially there will be: 1, have a stuffy nose: nasal obstruction feature is intermittence after suffering from rhinitis.By day, sky heat, nasal obstruction alleviates when working or move, and night, when sitting quietly or be cold, nasal obstruction increases the weight of.Another feature of nasal obstruction is alternately.During as lain on one's side, the congestion on the downside of residence, upside nasal airflow is good.Due to nasal obstruction, or have hyposmia, headache, giddy, speak in symptoms such as closed rhinolalias.2, many tears: be often mucus or glutinous purulence, even one-tenth purulence.Purulence occurs more than after sending out sexy dye season.3, olfactory sensation declines: mostly being caused by two kinds of reasons, one is tunica mucosa nasi swelling, nasal obstruction, and air-flow can not enter olfactory region；Two be regio olfactoria mucosa by chronic inflammatory disease long-time stimulus, olfactory function goes down or disappears.4, headache, giddy: chronic sinusitis shows as a sense of heaviness more.5, general manifestation: majority have headache, inappetence, the most tired, hypomnesis and insomnia etc..
Rhinitis, as a kind of common disease, endangers people healthy, brings the most constant to the life of people, especially chronic rhinitis, sinusitis etc., is difficult to the stubborn disease cured especially.In current medical circle, Chinese medicine effects a permanent cure to take stopgap measures, have no side effect etc. has advantage extensively by reception and the selection of people.People also attempt treating rhinitis by Chinese herbal medicine at present.The Chinese drugs agentia having had multiple treatment rhinitis is employing, but the constitutive material of these Chinese drugs agentias and component differ greatly, curative effect is the most different, and preparation method is the most complex, and made Chinese drugs agentia is also unfavorable for storing for a long time.
Summary of the invention
It is an object of the invention to solve existing the deficiencies in the prior art, it is provided that a kind of composition is simple, good effect, efficacy stability, prepare the pharmaceutical composition for the treatment of rhinitis simple, easy to use, that can store for a long time.
Further object is that the preparation method that a kind of pharmaceutical composition treating rhinitis is provided.
The technical solution adopted for the present invention to solve the technical problems is: the pharmaceutical composition for the treatment of rhinitis, the pharmaceutical composition of described treatment rhinitis is formed by the Raw material processing of following weight portion: Fructus Xanthii 40～60 parts, Flos Magnoliae 10～20 parts, Gypsum Fibrosum 40～60 parts, Rhizoma Coptidis 5～15 parts, Radix Scutellariae 10～20 parts, Radix Glycyrrhizae 5～15 parts, Mel 90～110 parts.
As preferably, the pharmaceutical composition of described treatment rhinitis is formed by the Raw material processing of following weight: Fructus Xanthii 50 parts, Flos Magnoliae 15 parts, Gypsum Fibrosum 50 parts, Rhizoma Coptidis 10 parts, Radix Scutellariae 15 parts, 10 parts of Radix Glycyrrhizae, Mel 100 parts.
As preferably, described rhinitis includes: acute or chronic rhinitis, acute and chronic sinusitis, allergic rhinitis, vasomotor rhinitis and atrophic rhinitis.
Present invention also offers the preparation method of a kind of pharmaceutical composition treating rhinitis, it is characterised in that: described preparation method comprises the following steps:
(1) weigh Fructus Xanthii, by weight, Flos Magnoliae, Gypsum Fibrosum, Rhizoma Coptidis, Radix Scutellariae, Radix Glycyrrhizae put into frying pan, then add 5～7 times of volume clear water in frying pan, and the height of clear water did not had medical material, then carry out dense decocting, dense decoct after take dense decocting liquid for the first time；
(2), carry out that second time is the denseest decocts again toward adding 5～7 times of volume clear water in frying pan, dense decoct after take the dense decocting liquid of second time；
(3), carry out that third time is the denseest decocts again toward adding 5～7 times of volume clear water in frying pan, dense decoct after take the dense decocting liquid of third time；
(4), by three dense pan-fried rear first, second and third time acquired dense decocting liquid mixing, medicine juice upon mixing adds Mel, after stirring, obtains the thick shape medicine juice of outer painting use；
(5), by thick shape medicine juice bottling packaging.
The calculating basis of the volume of described clear water is the weight of medical material.
The described dense water referring to add of decocting did not had medical material, and the medicine juice endured out will be close to sticky shape.
The property of medicine of each medicament composing prescription of the present invention is as follows:
Fructus Xanthii: sweet-bitter flavor, warm in nature, energy Pulvis Diaphoreticus rheumatism, upper logical brain top, reach outward skin, control headache, toothache, scrofula furuncle, clearing the nasal passage, control nasal sinusitis.
Flos Magnoliae: acrid in the mouth is warm in nature, can help clear sun in stomach to rise and lead in brain, and warming middle-JIAO expelling pathogenic factors from muscles leads to nine orifices, profit joint, dissipates lung meridian wind and cold, with clearing the nasal passage, for controlling the key medicine of nasal sinusitis.
Gypsum Fibrosum: acrid in the mouth, sweet, is slightly cold, clearing away heat-fire, and relieving restlessness cough-relieving cures mainly apoplexy cold and heat, and heart subinverse gas is frightened to be breathed heavily, xerostomia scorching tongue, it is impossible to breath, hardness and fullness in the abdomen pain, evil removing ghost, puerperium incised wound.
Rhizoma Coptidis: the big hardship of taste, property Great Cold, heat clearing and damp drying, eliminating fire and detoxication, the painful abdominal mass that disappears dysentery relieving, relieving restlessness of quenching one's thirst, the fire of removing pathogen in the heart stomach, control aphtha of the mouth and tongue, oral erosion pharyngalgia.
Radix Scutellariae: bitter in the mouth is cold in nature, dampness heat clearing away, kind lung heat clearing fire, based on the heat of eliminating the pathogens from the lung warp, control dysentery stomachache, jaundice five types of stranguria, ulcer sores, holding concurrently can arresting bleeding and miscarriage prevention.
Radix Glycyrrhizae: sweet in the mouth, property is flat, strengthening the spleen stomach, and coordinating the actions of various ingredients in a prescription solves hundred poison of drug, and the current twelve regular channels is controlled urine leaching pain, controlled sore swollen toxin, and laryngopharynx swelling and pain controlled by compatibility Radix Platycodonis.
The pharmacology of medicament composing prescription of the present invention is as follows: reaching top, mountain peak on Fructus Xanthii, dredge Naohu ailment said due to cold or exposure, Flos Magnoliae is specialized in into lung, and dispelling wind and ventilating the lung is sensible, and two medicines go directly brain nose, for controlling the special product of nasal sinusitis；The product medicine such as temperature pungent with Fructus Xanthii, Flos Magnoliae etc. of the bitter cold such as Rhizoma Coptidis, Radix Scutellariae removing toxic substances eliminating the pathogens from the lung is associated with, have again a merit of pungent drugs can disperse and bitter drugs can descend, it is aided with Gypsum Fibrosum heat-clearing and toxic substances removing soothing the liver effect, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, focus on dispelling wind sensible, but take into account eliminating turbid pathogen with aromatics and be amusing, cure mainly that nasal sinusitis is obstructed, do not hear perfume (or spice) and smell, the disease such as yellow many, the head nose pain of turbid amount of rhinorrhea with clear discharge.By adding Mel to strengthen toughness and the antibacterial ability of medicine juice, in order to external application medicine-feeding preserves with long-time, and Mel also has heat clearing away, invigorating middle warmer, moisturizes the effects such as analgesic antidotal.
The using method of the pharmaceutical composition of the treatment rhinitis of the present invention: be coated with use outside predominantly.After the viscous medicine juice of cotton swab rotation, filling in be coated with continuously in nostril and put on the skin, three times a day, medication can not be interrupted, till recovery from illness.
The present invention has that composition is simple, production procedure is simple and convenient, easy to use, be prone to the advantages such as storage, moreover it is possible to the effectively disease such as treatment nasal sinusitis is obstructed, do not hear perfume (or spice) smells, yellow many, the head nose pain of turbid amount of rhinorrhea with clear discharge, have significant curative effect, without recurrence, also have no side effect.
Detailed description of the invention
In order to make the technical problem to be solved, technical scheme and beneficial effect clearer, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
Embodiment 1:
A kind of pharmaceutical composition treating rhinitis, the pharmaceutical composition of described treatment rhinitis is formed by the Raw material processing of following weight: Fructus Xanthii 40g, Flos Magnoliae 20g, Gypsum Fibrosum 60g, Rhizoma Coptidis 5g, Radix Scutellariae 20g, Radix Glycyrrhizae 5g, Mel 90g.
Described rhinitis includes: acute or chronic rhinitis, acute and chronic sinusitis, allergic rhinitis, vasomotor rhinitis and atrophic rhinitis.
Present invention also offers the preparation method of a kind of pharmaceutical composition treating rhinitis, described preparation method comprises the following steps:
(1) weigh Fructus Xanthii, by weight, Flos Magnoliae, Gypsum Fibrosum, Rhizoma Coptidis, Radix Scutellariae, Radix Glycyrrhizae put into frying pan, then add 1L clear water in frying pan, and the height of clear water did not had medical material, then carry out dense decocting, dense decoct after take dense decocting liquid for the first time；
(2), carry out that second time is the denseest decocts again toward adding 1L clear water in frying pan, dense decoct after take the dense decocting liquid of second time；
(3), carry out that third time is the denseest decocts again toward adding 1L clear water in frying pan, dense decoct after take the dense decocting liquid of third time；
(4), by three dense pan-fried rear first, second and third time acquired dense decocting liquid mixing, medicine juice upon mixing adds Mel, after stirring, obtains the thick shape medicine juice of outer painting use；
(5), by thick shape medicine juice bottling packaging.
Embodiment 2:
A kind of pharmaceutical composition treating rhinitis, the pharmaceutical composition of described treatment rhinitis is formed by the Raw material processing of following weight: Fructus Xanthii 60g, Flos Magnoliae 10g, Gypsum Fibrosum 40g, Rhizoma Coptidis 15g, Radix Scutellariae 10g, Radix Glycyrrhizae 15g, Mel 110g.
Described rhinitis includes: acute or chronic rhinitis, acute and chronic sinusitis, allergic rhinitis, vasomotor rhinitis and atrophic rhinitis.
Present invention also offers the preparation method of a kind of pharmaceutical composition treating rhinitis, described preparation method comprises the following steps:
(1) weigh Fructus Xanthii, by weight, Flos Magnoliae, Gypsum Fibrosum, Rhizoma Coptidis, Radix Scutellariae, Radix Glycyrrhizae put into frying pan, then add 1L clear water in frying pan, and the height of clear water did not had medical material, then carry out dense decocting, dense decoct after take dense decocting liquid for the first time；
(2), carry out that second time is the denseest decocts again toward adding 1L clear water in frying pan, dense decoct after take the dense decocting liquid of second time；
(3), carry out that third time is the denseest decocts again toward adding 1L clear water in frying pan, dense decoct after take the dense decocting liquid of third time；
(4), by three dense pan-fried rear first, second and third time acquired dense decocting liquid mixing, medicine juice upon mixing adds Mel, after stirring, obtains the thick shape medicine juice of outer painting use；
(5), by thick shape medicine juice bottling packaging.
Embodiment 3:
A kind of pharmaceutical composition treating rhinitis, the pharmaceutical composition of described treatment rhinitis is formed by the Raw material processing of following weight: Fructus Xanthii 60g, Flos Magnoliae 20g, Gypsum Fibrosum 60g, Rhizoma Coptidis 15g, Radix Scutellariae 20g, Radix Glycyrrhizae 15g, Mel 110g.
Described rhinitis includes: acute or chronic rhinitis, acute and chronic sinusitis, allergic rhinitis, vasomotor rhinitis and atrophic rhinitis.
Present invention also offers the preparation method of a kind of pharmaceutical composition treating rhinitis, described preparation method comprises the following steps:
(1) weigh Fructus Xanthii, by weight, Flos Magnoliae, Gypsum Fibrosum, Rhizoma Coptidis, Radix Scutellariae, Radix Glycyrrhizae put into frying pan, then add 1L clear water in frying pan, and the height of clear water did not had medical material, then carry out dense decocting, dense decoct after take dense decocting liquid for the first time；
(2), carry out that second time is the denseest decocts again toward adding 1L clear water in frying pan, dense decoct after take the dense decocting liquid of second time；
(3), carry out that third time is the denseest decocts again toward adding 1L clear water in frying pan, dense decoct after take the dense decocting liquid of third time；
(4), by three dense pan-fried rear first, second and third time acquired dense decocting liquid mixing, medicine juice upon mixing adds Mel, after stirring, obtains the thick shape medicine juice of outer painting use；
(5), by thick shape medicine juice bottling packaging.
Embodiment 4:
A kind of pharmaceutical composition treating rhinitis, the pharmaceutical composition of described treatment rhinitis is formed by the Raw material processing of following weight: Fructus Xanthii 40, Flos Magnoliae 10g, Gypsum Fibrosum 40g, Rhizoma Coptidis 5g, Radix Scutellariae 10g, Radix Glycyrrhizae 5g, Mel 90g.
Described rhinitis includes: acute or chronic rhinitis, acute and chronic sinusitis, allergic rhinitis, vasomotor rhinitis and atrophic rhinitis.
Present invention also offers the preparation method of a kind of pharmaceutical composition treating rhinitis, described preparation method comprises the following steps:
(1) weigh Fructus Xanthii, by weight, Flos Magnoliae, Gypsum Fibrosum, Rhizoma Coptidis, Radix Scutellariae, Radix Glycyrrhizae put into frying pan, then add 0.8L clear water in frying pan, and the height of clear water did not had medical material, then carry out dense decocting, dense decoct after take dense decocting liquid for the first time；
(2), carry out that second time is the denseest decocts again toward adding 0.8L clear water in frying pan, dense decoct after take the dense decocting liquid of second time；
(3), carry out that third time is the denseest decocts again toward adding 0.8L clear water in frying pan, dense decoct after take the dense decocting liquid of third time；
(4), by three dense pan-fried rear first, second and third time acquired dense decocting liquid mixing, medicine juice upon mixing adds Mel, after stirring, obtains the thick shape medicine juice of outer painting use；
(5), by thick shape medicine juice bottling packaging.
Embodiment 5:
A kind of pharmaceutical composition treating rhinitis, the pharmaceutical composition of described treatment rhinitis is formed by the Raw material processing of following weight: Fructus Xanthii 50g, Flos Magnoliae 15g, Gypsum Fibrosum 50g, Rhizoma Coptidis 10g, Radix Scutellariae 15g, Radix Glycyrrhizae 10g, Mel 100g.
Described rhinitis includes: acute or chronic rhinitis, acute and chronic sinusitis, allergic rhinitis, vasomotor rhinitis and atrophic rhinitis.
Present invention also offers the preparation method of a kind of pharmaceutical composition treating rhinitis, described preparation method comprises the following steps:
(1) weigh Fructus Xanthii, by weight, Flos Magnoliae, Gypsum Fibrosum, Rhizoma Coptidis, Radix Scutellariae, Radix Glycyrrhizae put into frying pan, then add 1L clear water in frying pan, and the height of clear water did not had medical material, then carry out dense decocting, dense decoct after take dense decocting liquid for the first time；
(2), carry out that second time is the denseest decocts again toward adding 1L clear water in frying pan, dense decoct after take the dense decocting liquid of second time；
(3), carry out that third time is the denseest decocts again toward adding 1L clear water in frying pan, dense decoct after take the dense decocting liquid of third time；
(4), by three dense pan-fried rear first, second and third time acquired dense decocting liquid mixing, medicine juice upon mixing adds Mel, after stirring, obtains the thick shape medicine juice of outer painting use；
(5), by thick shape medicine juice bottling packaging.
The pharmaceutical composition for the treatment of rhinitis of the present invention is applied through out-patient 450 example, wherein minimum 13 years old of age, maximum 61 years old, after medication, has 428 patients' recoveries from illness and without recurrence, and also 18 patient's Rhinitis Symptoms take a turn for the better but are not completely recovered.
Show through clinical trial: it is more than 95% (recovery from illness performance: nasal airflow is good that the present invention treats the cure rate of the pharmaceutical composition of rhinitis, headache disappears, secretion object is little, concha nasalis is the loosest), effective percentage be more than 99% (effectively performance: improved before nasal airflow situation and concha nasalis big situation the most relatively medication, but the most normal).
A few example clinical practice examples are as follows:
Mr. Zhang, man, 38 years old, firmly Cangnan, Zhejiang Province county, suffer from chronic paranasal rhinitis for many years, do not hear perfume (or spice) and smell, with the pharmaceutical composition two bottles of the treatment rhinitis of the present invention, Rhinitis Symptoms eliminates, can hear perfume (or spice) and smell.
Mr. Xia, man, 28 years old, firmly Zhejiang Province's Rui'an City, mobility's rhinitis, with the pharmaceutical composition three bottles of the treatment rhinitis of the present invention, recovery from illness, does not recurs.
Mr. Zhang, man, 39 years old, firmly Fuding City of Fujian Province, suffer from atrophic rhinitis, with the pharmaceutical composition two bottles of the treatment rhinitis of the present invention, recovery from illness, do not recur.
Mrs Gao, female, 51 years old, firmly Cangnan, Zhejiang Province county, suffer from chronic rhinitis for many years, with the pharmaceutical composition three bottles of the treatment rhinitis of the present invention, Rhinitis Symptoms eliminates, does not has recurrence.
Mrs Lin, female, 31 years old, firmly Wenzhou City, Zhejiang Province, suffer from allergic rhinitis, slightly flu i.e. sneeze is continuous, with the pharmaceutical composition two bottles of the treatment rhinitis of the present invention, transference cure, does not recurs.
Embodiment described above is the one preferably scheme of the present invention, and the present invention not makees any pro forma restriction, also has other variant and remodeling on the premise of without departing from the technical scheme described in claim.
Claims (4)
1. treat the pharmaceutical composition of rhinitis, it is characterised in that: the pharmaceutical composition of described treatment rhinitis is formed by the Raw material processing of following weight portion: Fructus Xanthii 40～60 parts, Flos Magnoliae 10～20 parts, Gypsum Fibrosum 40～60 parts, Rhizoma Coptidis 5～15 parts, Radix Scutellariae 10～20 parts, Radix Glycyrrhizae 5～15 parts, Mel 90～110 parts.
The pharmaceutical composition for the treatment of rhinitis the most according to claim 1, it is characterised in that: the pharmaceutical composition of described treatment rhinitis is formed by the Raw material processing of following weight portion: Fructus Xanthii 50 parts, Flos Magnoliae 15 parts, Gypsum Fibrosum 50 parts, Rhizoma Coptidis 10 parts, Radix Scutellariae 15 parts, 10 parts of Radix Glycyrrhizae, Mel 100 parts.
The pharmaceutical composition for the treatment of rhinitis the most according to claim 1, it is characterised in that: described rhinitis includes: acute or chronic rhinitis, acute and chronic sinusitis, allergic rhinitis, vasomotor rhinitis and atrophic rhinitis.
4. the preparation method of the pharmaceutical composition treating rhinitis, it is characterised in that: described preparation method comprises the following steps:
(1) weigh Fructus Xanthii, by weight, Flos Magnoliae, Gypsum Fibrosum, Rhizoma Coptidis, Radix Scutellariae, Radix Glycyrrhizae put into frying pan, then add 5～7 times of volume clear water in frying pan, and the height of clear water did not had medical material, then carry out dense decocting, dense decoct after take dense decocting liquid for the first time；
(2), carry out that second time is the denseest decocts again toward adding 5～7 times of volume clear water in frying pan, dense decoct after take the dense decocting liquid of second time；
(3), carry out that third time is the denseest decocts again toward adding 5～7 times of volume clear water in frying pan, dense decoct after take the dense decocting liquid of third time；
(4), by three dense pan-fried rear first, second and third time acquired dense decocting liquid mixing, medicine juice upon mixing adds Mel, after stirring, obtains the thick shape medicine juice of outer painting use；
(5), by thick shape medicine juice bottling packaging.
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| CN201510182960.9A CN106138279A (en) | 2015-04-17 | 2015-04-17 | Pharmaceutical composition for the treatment of rhinitis and preparation method thereof |
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| CN201510182960.9A CN106138279A (en) | 2015-04-17 | 2015-04-17 | Pharmaceutical composition for the treatment of rhinitis and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106974972A (en) * | 2017-04-17 | 2017-07-25 | 广西大学 | A kind of oral liquid for treating rhinitis |
| CN107714840A (en) * | 2017-11-27 | 2018-02-23 | 竹溪县明俊意蜂养殖专业合作社 | A kind of Chinese medicine for treating rhinitis |
-
2015
- 2015-04-17 CN CN201510182960.9A patent/CN106138279A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106974972A (en) * | 2017-04-17 | 2017-07-25 | 广西大学 | A kind of oral liquid for treating rhinitis |
| CN107714840A (en) * | 2017-11-27 | 2018-02-23 | 竹溪县明俊意蜂养殖专业合作社 | A kind of Chinese medicine for treating rhinitis |
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