CN106138159A - The pharmaceutical composition of the insomnia that a kind of prevention and treatment anoxia cause - Google Patents
The pharmaceutical composition of the insomnia that a kind of prevention and treatment anoxia cause Download PDFInfo
- Publication number
- CN106138159A CN106138159A CN201610634801.2A CN201610634801A CN106138159A CN 106138159 A CN106138159 A CN 106138159A CN 201610634801 A CN201610634801 A CN 201610634801A CN 106138159 A CN106138159 A CN 106138159A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- radix rhodiolae
- insomnia
- prevention
- theanine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of prevention and treat the pharmaceutical composition of the insomnia that anoxia causes；The active component of described pharmaceutical composition and mass fraction thereof be: Radix Rhodiolae extract 1 part, theanine 0.2～0.3 part.The present invention passes through Radix Rhodiolae extract and the reasonable compatibility of theanine, and the pharmaceutical composition obtained can help for sleep again by anti-hypoxia, and pharmaceutical purity is natural, it is to avoid calm class side effects of pharmaceutical drugs.The present invention farthest solves the insomnia problem that altitude sickness causes, and for slight altitude sickness causes the best patient of sleep quality, this product is optimal.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine, relate to a kind of prevention and treat the medicine group of the insomnia that anoxia causes
Compound.
Background technology
Altitude sickness is the body a kind of emergency reaction under special state, is easy to cause and sleeps under Altitude state
Sleep the best, although the length of one's sleep is long, but poor sleeping quality, easily wake up with a start, be in a kind of sleeping state all the time.
If patient injects or is administered orally the calm class medicine such as chlorpromazine, diazepam (stabilizing) to treat Altitude state
Under the insomnia that causes, owing to this type of medicine has the side effect that suppression is breathed, easily because dosage is grasped inaccurate, cause breathing tired
Difficult, to increase the weight of degree of oxygen deficiency problem.
Accordingly, it would be desirable to develop a kind of can the pure natural medical compositions that can help for sleep again of anti-hypoxia, farthest
Solve the insomnia problem that altitude sickness causes.
Summary of the invention
It is an object of the invention to: the problem existed for prior art, it is provided that a kind of prevention and treatment anoxia cause
The pharmaceutical composition of insomnia, can help for sleep again by anti-hypoxia, and pharmaceutical purity is natural, it is to avoid calm class side effects of pharmaceutical drugs.
To achieve these goals, the technical solution used in the present invention is:
The pharmaceutical composition of insomnia that a kind of prevention and treatment anoxia cause, the active component of described pharmaceutical composition and
Mass fraction is: Radix Rhodiolae extract 1 part, theanine 0.2～0.3 part.
As the preferred version of the present invention, the active component of described pharmaceutical composition and mass fraction thereof it is: Radix Rhodiolae carries
Take thing 1 part, theanine 0.2 part.
As the preferred version of the present invention, described pharmaceutical composition also includes microcrystalline Cellulose, silicon dioxide, lactose, shallow lake
One or more adjuvants in powder, magnesium stearate and carboxymethylstach sodium.
As the preferred version of the present invention, the dosage form of described pharmaceutical composition is capsule, tablet, oral liquid, chews
Sheet, buccal tablet or granule.
As the preferred version of the present invention, described Radix Rhodiolae extract is prepared by following methods:
(1) Radix Rhodiolae dry rhizome is pulverized, be placed in the ethanol that mass concentration is 80%～95% immersion 1～3 little
Time；Impregnate 24 hours with the ethanol as solvent that mass concentration is 50%～70% again；
(2) ethanol that Radix Rhodiolae mass concentration is 50%～70% after step (1) being soaked and impregnated carries out percolation,
Ethanol consumption is 6～12 times of Radix Rhodiolae volume, and the percolation time is 12～48 hours；Collect percolate, reclaim ethanol, then subtract
Pressure is concentrated into the clear paste that relative density is 1.10～1.15, is spray dried to fine powder, i.e. obtains Radix Rhodiolae extract.
The beneficial effects of the present invention is:
The present invention pass through Radix Rhodiolae extract and the reasonable compatibility of theanine, the pharmaceutical composition obtained can anti-hypoxia again
Can help for sleep, and pharmaceutical purity is natural, it is to avoid calm class side effects of pharmaceutical drugs.The present invention farthest solves plateau
The insomnia problem that causes of reaction, for slight altitude sickness causes the best patient of sleep quality, this product is optimal.
Accompanying drawing explanation
Fig. 1 is orthogonal table；
Fig. 2 is Radix Rhodiolae extract, theanine orthogonal design analytical table directly perceived；
Fig. 3 is main body effect check analysis；
Fig. 4 is reciprocal action result；
Fig. 5 is orthogonal experiment analysis chart directly perceived.
Detailed description of the invention
In order to make the object, technical solutions and advantages of the present invention clearer, below in conjunction with excellent to the present invention of accompanying drawing
Embodiment is selected to be described in detail.
Embodiment 1
(1) Radix Rhodiolae dry rhizome is pulverized, be placed in the ethanol that mass concentration is 90% immersion 2 hours；Use matter again
Measure the ethanol as solvent that concentration is 60% to impregnate 24 hours；
(2) ethanol that Radix Rhodiolae mass concentration is 60% after step (1) being soaked and impregnated carries out percolation, and ethanol is used
Amount is 10 times of Radix Rhodiolae volume, and the percolation time is 18 hours；Collect percolate, reclaim ethanol, be then evaporated to relatively
Density is the clear paste of 1.10～1.15, is spray dried to fine powder, i.e. obtains Radix Rhodiolae extract；
(3) weighing Radix Rhodiolae extract 1 part, theanine 0.2 part, magnesium stearate 0.35 part, silicon dioxide 0.04 part is (with matter
Amount part meter)；Radix Rhodiolae extract, theanine and magnesium stearate are mixed 30min, it is ensured that mix homogeneously, by mass concentration be
The alcohol granulation of 50%, is dried；
(4) granule always mixes: add silicon dioxide, mixing；
(5) capsule is filled: fill capsule with capsule filler.
Embodiment 2
Embodiment 2 compared with Example 1, differs only in: Radix Rhodiolae extract and the dose ratio of theanine in embodiment 2
Example is: Radix Rhodiolae extract 1 part, theanine 0.3 part.
Comparative example 1
Comparative example 1 compared with Example 1, differs only in: Radix Rhodiolae extract and the dose ratio of theanine in comparative example 1
Example is: Radix Rhodiolae extract 0.8 part, theanine 0.1 part.
Comparative example 2
Comparative example 2 compared with Example 1, differs only in: Radix Rhodiolae extract and the dose ratio of theanine in comparative example 2
Example is: Radix Rhodiolae extract 0.8 part, theanine 0.2 part.
Comparative example 3
Comparative example 3 compared with Example 1, differs only in: Radix Rhodiolae extract and the dose ratio of theanine in comparative example 3
Example is: Radix Rhodiolae extract 0.8 part, theanine 0.3 part.
Comparative example 4
Comparative example 4 compared with Example 1, differs only in: Radix Rhodiolae extract and the dose ratio of theanine in comparative example 4
Example is: Radix Rhodiolae extract 1 part, theanine 0.1 part.
Comparative example 5
Comparative example 5 compared with Example 1, differs only in: Radix Rhodiolae extract and the dose ratio of theanine in comparative example 5
Example is: Radix Rhodiolae extract 1.2 parts, theanine 0.1 part.
Comparative example 6
Comparative example 6 compared with Example 1, differs only in: Radix Rhodiolae extract and the dose ratio of theanine in comparative example 6
Example is: Radix Rhodiolae extract 1.2 parts, theanine 0.2 part.
Comparative example 7
Comparative example 7 compared with Example 1, differs only in: Radix Rhodiolae extract and the dose ratio of theanine in comparative example 7
Example is: Radix Rhodiolae extract 1.2 parts, theanine 0.3 part.
Zoopery
In the pharmaceutical composition of above-described embodiment 1-2 and comparative example 1-7, Radix Rhodiolae extract and the dose ratio of theanine
Meet the orthogonal table shown in Fig. 1.
Take 45 mice equilibriums and be randomly divided into 9 groups, by 45 mice fasting 12h before test, press orthogonal experiment respectively secondary morning
9 dosage combination gastric infusions；After 60min, record the autonomous of each group of mice 30min successively with mice autonomic activities monitor
Movable number of times, result is shown in Fig. 2～Fig. 5 respectively.
Result and analysis:
1) as shown in Figure 2, A factor (Radix Rhodiolae extract) extreme difference is more than B factor (theanine), therefore Radix Rhodiolae extract
For main effect, the extreme difference of theanine is little, acts on weak, is auxiliary effect.
2) SPSS 19.0 is used to analyze, from the figure 3, it may be seen that with mice autonomic activities number of times as dependent variable, by each target
Effect is checked, and the variance analysis compared between single argument group understands: the A factor (Radix Rhodiolae extract) effect in prescription is the strongest
(P < 0.05), for mainly affecting composition；The effect of theanine is taken second place (0.05 < P < 0.25), for auxiliary element.
3) it is following from Fig. 4 reciprocal action interpretation of result and Fig. 5 analysis chart directly perceived, Radix Rhodiolae extract and theanine
During ratio range: Radix Rhodiolae extract 1 part, theanine 0.2～0.3 part；Mice autonomic activities number of times substantially reduces, and shows red scape
It extract and theanine serve the effect of tranquillizing and allaying excitement under this proportioning.
Finally illustrating, above example is only in order to illustrate technical scheme and unrestricted, although by ginseng
According to the preferred embodiments of the present invention, invention has been described, it should be appreciated by those of ordinary skill in the art that can
In the form and details it is made various change, the present invention limited without departing from appended claims
Spirit and scope.
Claims (5)
1. the pharmaceutical composition of the insomnia that a prevention and treatment anoxia cause, it is characterised in that: the work of described pharmaceutical composition
Property composition and mass fraction thereof be: Radix Rhodiolae extract 1 part, theanine 0.2～0.3 part.
The pharmaceutical composition of the insomnia that prevention the most according to claim 1 and treatment anoxia cause, it is characterised in that: described
The active component of pharmaceutical composition and mass fraction thereof be: Radix Rhodiolae extract 1 part, theanine 0.2 part.
The pharmaceutical composition of the insomnia that prevention the most according to claim 1 and treatment anoxia cause, it is characterised in that: described
Pharmaceutical composition also include the one in microcrystalline Cellulose, silicon dioxide, lactose, starch, magnesium stearate and carboxymethylstach sodium or
Several adjuvants.
The pharmaceutical composition of the insomnia that prevention the most according to claim 1 and treatment anoxia cause, it is characterised in that: described
The dosage form of pharmaceutical composition is capsule, tablet, oral liquid, chewable tablet, buccal tablet or granule.
5. the pharmaceutical composition of the insomnia caused according to the prevention described in Claims 1-4 any one and treatment anoxia, it is special
Levy and be: described Radix Rhodiolae extract is prepared by following methods:
(1) Radix Rhodiolae dry rhizome is pulverized, be placed in the ethanol that mass concentration is 80%～95% immersion 1～3 hours；Again
Impregnate 24 hours with the ethanol as solvent that mass concentration is 50%～70%；
(2) ethanol that Radix Rhodiolae mass concentration is 50%～70% after step (1) being soaked and impregnated carries out percolation, ethanol
Consumption is 6～12 times of Radix Rhodiolae volume, and the percolation time is 12～48 hours；Collect percolate, reclaim ethanol, then reduce pressure dense
It is reduced to the clear paste that relative density is 1.10～1.15, is spray dried to fine powder, i.e. obtain Radix Rhodiolae extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610634801.2A CN106138159A (en) | 2016-08-05 | 2016-08-05 | The pharmaceutical composition of the insomnia that a kind of prevention and treatment anoxia cause |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610634801.2A CN106138159A (en) | 2016-08-05 | 2016-08-05 | The pharmaceutical composition of the insomnia that a kind of prevention and treatment anoxia cause |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106138159A true CN106138159A (en) | 2016-11-23 |
Family
ID=57329146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610634801.2A Pending CN106138159A (en) | 2016-08-05 | 2016-08-05 | The pharmaceutical composition of the insomnia that a kind of prevention and treatment anoxia cause |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106138159A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108114045A (en) * | 2018-01-25 | 2018-06-05 | 四川吉晟生物医药有限公司 | A kind of Chinese medicine composition for preventing and treating anoxic cause insomnia and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060286183A1 (en) * | 2005-06-17 | 2006-12-21 | Gardiner Paul T | Diet supplement for causing rapid weight loss, controlling appetite, managing stress, supporting relaxation, combating fatigue and supporting mental well-being |
| CN102697035A (en) * | 2012-04-10 | 2012-10-03 | 苟春虎 | Cordyceps anti-aging pellet |
| CN102972776A (en) * | 2012-12-05 | 2013-03-20 | 溧阳维信生物科技有限公司 | Sucralose-containing traditional Chinese medicine health-care product and method for preparing same |
| WO2014151364A1 (en) * | 2013-03-15 | 2014-09-25 | Buck Institute For Research On Aging | Improved cognitive supplements |
-
2016
- 2016-08-05 CN CN201610634801.2A patent/CN106138159A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060286183A1 (en) * | 2005-06-17 | 2006-12-21 | Gardiner Paul T | Diet supplement for causing rapid weight loss, controlling appetite, managing stress, supporting relaxation, combating fatigue and supporting mental well-being |
| CN102697035A (en) * | 2012-04-10 | 2012-10-03 | 苟春虎 | Cordyceps anti-aging pellet |
| CN102972776A (en) * | 2012-12-05 | 2013-03-20 | 溧阳维信生物科技有限公司 | Sucralose-containing traditional Chinese medicine health-care product and method for preparing same |
| WO2014151364A1 (en) * | 2013-03-15 | 2014-09-25 | Buck Institute For Research On Aging | Improved cognitive supplements |
Non-Patent Citations (3)
| Title |
|---|
| 中国科学院西北高原研究所和青海省药品检验所编: "《青藏红景天》", 31 October 2009, 陕西科学技术出版社 * |
| 缪勇等主编，: "《中草药植物提取与深加工新技术实用手册 第三卷》", 30 April 2004, 天津电子出版社 * |
| 许光辉等: ""红景天苷对失眠大鼠睡眠周期的影响"", 《医学研究生学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108114045A (en) * | 2018-01-25 | 2018-06-05 | 四川吉晟生物医药有限公司 | A kind of Chinese medicine composition for preventing and treating anoxic cause insomnia and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20121072T1 (en) | Methods of administering tetrahydrobiopterin, associated compositions, and methods of measuring | |
| ES2709633T3 (en) | Use of an extract of Ginkgo biloba leaves | |
| CN104000197B (en) | A kind of health products or pharmaceutical composition and its production and use of fatigue-relieving | |
| CN103041197A (en) | Traditional Chinese medicine composition for treating hypertension | |
| WO2021109511A1 (en) | Anti-fatigue composition and preparation method therefor | |
| CN106138159A (en) | The pharmaceutical composition of the insomnia that a kind of prevention and treatment anoxia cause | |
| CN103989695B (en) | A kind of pharmaceutical composition and application thereof treating bronchial asthma | |
| CN100512796C (en) | Medicinal composition containing scutellaria glucoside and bupleurum and its preparation method | |
| JP2014166994A (en) | Novel chinese medicine extract formulation | |
| CN103099862B (en) | External preparation for treating rheumatism pain disease, as well as preparation method and application thereof | |
| CN103919845B (en) | A kind of pharmaceutical composition for improving anoxia endurance and its preparation method and application | |
| CN101284051A (en) | Ji Chuan Jian oral preparation and preparation method thereof | |
| CN104069171A (en) | Antidepressant medicine composition as well as preparation method and application thereof | |
| CN107951940B (en) | Blood pressure lowering medicine composition | |
| CN102406778A (en) | Traditional Chinese medicine composition for treating Alzheimer type dementia and preparation method thereof | |
| CN101849993B (en) | Chinese medicinal sustained release tablets for treating dysentery and enteritis of livestock and poultry | |
| CN103948688B (en) | A kind of pharmaceutical composition and application thereof containing 5-fluorouracil | |
| CN103961428B (en) | A kind of detection method of the Chinese medicinal composition preparation with promoting flow of QI and blood effect | |
| CN107753551B (en) | Composition with function of reducing blood pressure and preparation method thereof | |
| JP2005289942A (en) | Peripheral circulation improver preparation | |
| JP2000229853A (en) | Menstruation pain-improving composition | |
| CN101683376A (en) | Patch for treating toothache and method for producing the same | |
| CN107125756B (en) | Functional food composition and oral preparation, preparation method and application thereof | |
| CN106215154A (en) | The Chinese medicine compound of the treatment nocturnal fretfulness in infants | |
| CN105998629A (en) | Traditional Chinese medicine composition for treating syndrome of qi stagnation and blood stasis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161123 |