CN106110119A - 一种兽用清瘟解毒口服液及其制备方法 - Google Patents
一种兽用清瘟解毒口服液及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种兽用清瘟解毒口服液及其制备方法,包括以下重量份的原料:地黄25‑40份、栀子40‑60份、黄芩40‑50份、连翘30‑50份、玄参25‑40份、板蓝根30‑50份、金银花30‑50份、炙百部20‑30份、桑白皮20‑35份、重楼10‑15份、贯众10‑13份、甘草10‑15份。本发明的兽用清瘟解毒口服液,具有抗菌、抗病毒、扶正固体、清热解毒,补血活血、益气健脾,增进食欲,增进生长,提高机体免疫功能,对畜禽的瘟热毒症疗效独特,对由病毒或细菌引起的畜禽各类疾病均有显著疗效,而且不易沉淀;另外最大限度地提取出了中药的有效成分,提高经济效益。
Description
技术领域
本发明涉及兽用中药技术领域,尤其涉及一种兽用清瘟解毒口服液及其制备方法。
背景技术
目前《兽药地方标准升国家标准》第二册对清瘟解毒口服液的制备方法为:以制备1000mL口服液为例,将地黄150g、栀子250g、黄芩225g、连翘200g、玄参150g和板蓝根200g加水煎煮两次,合并煎液,静置,滤过,浓缩,滤过,加水至1000ml,灌装、灭菌即得。现有的清瘟解毒口服液通常组方简单,效果并不是很显著,而且存在静置存放易产生沉淀物的弊端。另外,传统工艺提取清瘟解毒口服液,往往提取效率较低,且有效成分的收率偏低,大量有效成分在植物细胞壁中没有释放到提取溶媒中,除杂效率低,且易损失较多的有效成分,大大降低了制备的经济效益。
发明内容
本发明的目的是克服现有技术的不足,提供一种兽用清瘟解毒口服液,以纯天然中兽药为成分,组方合理,具有抗菌、抗病毒、扶正固体、清热解毒,、补血活血、益气健脾,增进食欲,增进生长,提高机体免疫功能,对畜禽的瘟热毒症疗效独特,对由病毒或细菌引起的畜禽各类疾病均有显著疗效,可用于禽新城疫、法氏囊等病毒病以及病毒性呼吸道病、慢性呼吸道病等,而且解决目前中兽药口服液存放一段时间后易产生沉淀物的难题;另外用生物酶辅助提取药材中有效成分,提高药材有效成分的溶出率,最大限度地提取出了中药的有效成分,并很好的去除了中药提取液中的有害物质和杂质,绿色无污染,防腐保质效果好。
本发明的另一目的是提高该兽用清瘟解毒口服液的制备方法。
为了实现上述目的,本发明采用如下技术方案:
一种兽用清瘟解毒口服液,包括以下重量份的原料:地黄25-40份、栀子40-60份、黄芩40-50份、连翘30-50份、玄参25-40份、板蓝根30-50份、金银花30-50份、炙百部20-30份、桑白皮20-35份、重楼10-15份、贯众10-13份、甘草10-15份。
所述的兽用清瘟解毒口服液的制备方法,包括以下步骤:
(1)按上述重量份比例取各中药原料,将中药原料粉碎;取中药原料总重量7-10倍重量的水加热至80-85℃,加入粉碎后的中药,恒温浸泡10-20分钟;然后将药液降温至45-50℃,调节pH至4.5-5.0,加入复合酶,搅拌均匀,酶解1-3h,然后升温至75-80℃进行酶灭活处理;所述复合酶为纤维素酶、果胶酶、淀粉酶的混合物,质量配比为,纤维素酶∶果胶酶∶淀粉酶=2-3∶1-2∶0.5-0.8;其中纤维素酶酶活以20000U/g计,用量不小于1.0g,果胶酶酶活以50000U/g计,用量不小于1.0g,淀粉酶酶活以30000U/g计,用量不小于1.0g;
(2)将步骤(1)酶解后药液煎煮两次,第一次加入药液重量5-8倍的水煎煮1-2h,第二次加入药渣重量5-7倍的水煎煮1-2h,过滤,将两次煎煮液合并;
(3)将合并后的煎煮液减压浓缩至相对密度为1.05-1.06,向减压浓缩后的药液中加入95%乙醇进行醇沉,过滤,往滤液中加入防腐剂苯甲酸钠2-5重量份、乳化剂吐温10-20重量份,搅匀,调节pH值至4.3-5.0,加蒸馏水定容至配制量,灌装、灭菌即得清瘟解毒口服液成品。
本发明中地黄、栀子、黄芩、连翘、玄参、板蓝根使常用的清瘟解毒药物组合,本发明保留原有组分,加入金银花、炙百部、桑白皮、重楼、贯众、甘草,可以大大提高本发明的药效。其中,炙百部:味甘润,性苦降,微温,归肺经,有润肺止咳,化浊解毒祛邪之效;桑白皮:味甘,性寒,归肺经。具有泻肺平喘,利水消肿的功效,用于肺热喘咳等症;重楼:苦,微寒,归肝经,有清热解毒,消肿止痛之功,本品苦寒入肝,尚有凉肝泄热作用;贯众:味苦,性微寒,归肝;胃经,具有清热、解毒、平肝之功效,用于风热感冒;金银花:味甘,性寒。归肺、心、胃经。具有清热解毒,疏散风热功效。用于风热感冒,温热发病;甘草:性平、味平、入心、肺、脾、胃经。有补脾益气、清热解毒、去痰止咳、缓急止痛、调和诸药之功效。
本发明的中药组合物具有清热解毒,清肺止嗽、利痰定喘的功能,清瘟解毒、凉血解表,可用于畜禽病毒性感冒、新城疫、类减蛋综合征、传染性法氏囊病、传支、传喉、细小病毒病、鸡痘等各种病毒性疾病或上呼吸道感染。
与已有技术相比,本发明的有益效果如下:
本发明的兽用清瘟解毒口服液,以纯天然中兽药为成分,组方合理,具有抗菌、抗病毒、扶正固体、清热解毒,、补血活血、益气健脾,增进食欲,增进生长,提高机体免疫功能,对畜禽的瘟热毒症疗效独特,对由病毒或细菌引起的畜禽各类疾病均有显著疗效,可用于禽新城疫、法氏囊等病毒病以及病毒性呼吸道病、慢性呼吸道病等,而且解决目前中兽药口服液存放一段时间后易产生沉淀物的难题;另外用生物酶辅助提取药材中有效成分,提高药材有效成分的溶出率,最大限度地提取出了中药的有效成分,并很好的去除了中药提取液中的有害物质和杂质,绿色无污染,防腐保质效果好。
具体实施方式
以下结合实施例对本发明作进一步的说明,但本发明不仅限于这些实施例,在未脱离本发明宗旨的前提下,所作的任何改进均落在本发明的保护范围之内。
实施例1:
一种兽用清瘟解毒口服液,包括以下重量份的原料:地黄25份、栀子50份、黄芩45份、连翘40份、玄参30份、板蓝根40份、金银花40份、炙百部25份、桑白皮30份、重楼15份、贯众10份、甘草10份。
所述的兽用清瘟解毒口服液的制备方法,包括以下步骤:
(1)按上述重量份比例取各中药原料,将中药原料粉碎;取中药原料总重量7倍重量的水加热至85℃,加入粉碎后的中药,恒温浸泡10分钟;然后将药液降温至45℃,调节pH至4.5,加入复合酶,搅拌均匀,酶解3h,然后升温至75℃进行酶灭活处理;所述复合酶为纤维素酶、果胶酶、淀粉酶的混合物,质量配比为,纤维素酶∶果胶酶∶淀粉酶=2∶1∶0.5;其中纤维素酶酶活以20000U/g计,用量不小于1.0g,果胶酶酶活以50000U/g计,用量不小于1.0g,淀粉酶酶活以30000U/g计,用量不小于1.0g;
(2)将步骤(1)酶解后药液煎煮两次,第一次加入药液重量5倍的水煎煮2h,第二次加入药渣重量5倍的水煎煮2h,过滤,将两次煎煮液合并;
(3)将合并后的煎煮液减压浓缩至相对密度为1.05,向减压浓缩后的药液中加入95%乙醇进行醇沉,过滤,往滤液中加入防腐剂苯甲酸钠2重量份、乳化剂吐温10重量份,搅匀,调节pH值至4.3,加蒸馏水定容至配制量,灌装、灭菌即得清瘟解毒口服液成品。
实施例2:
一种兽用清瘟解毒口服液,包括以下重量份的原料:地黄40份、栀子60份、黄芩40份、连翘50份、玄参25份、板蓝根50份、金银花50份、炙百部20份、桑白皮20份、重楼15份、贯众13份、甘草15份。
所述的兽用清瘟解毒口服液的制备方法,包括以下步骤:
(1)按上述重量份比例取各中药原料,将中药原料粉碎;取中药原料总重量10倍重量的水加热至85℃,加入粉碎后的中药,恒温浸泡20分钟;然后将药液降温至50℃,调节pH至4.5,加入复合酶,搅拌均匀,酶解3h,然后升温至80℃进行酶灭活处理;所述复合酶为纤维素酶、果胶酶、淀粉酶的混合物,质量配比为,纤维素酶∶果胶酶∶淀粉酶=3∶2∶0.8;其中纤维素酶酶活以20000U/g计,用量不小于1.0g,果胶酶酶活以50000U/g计,用量不小于1.0g,淀粉酶酶活以30000U/g计,用量不小于1.0g;
(2)将步骤(1)酶解后药液煎煮两次,第一次加入药液重量8倍的水煎煮1h,第二次加入药渣重量7倍的水煎煮2h,过滤,将两次煎煮液合并;
(3)将合并后的煎煮液减压浓缩至相对密度为1.06,向减压浓缩后的药液中加入95%乙醇进行醇沉,过滤,往滤液中加入防腐剂苯甲酸钠5重量份、乳化剂吐温20重量份,搅匀,调节pH值至5.0,加蒸馏水定容至配制量,灌装、灭菌即得清瘟解毒口服液成品。
Claims (2)
1.一种兽用清瘟解毒口服液,其特征在于:包括以下重量份的原料:地黄25-40份、栀子40-60份、黄芩40-50份、连翘30-50份、玄参25-40份、板蓝根30-50份、金银花30-50份、炙百部20-30份、桑白皮20-35份、重楼10-15份、贯众10-13份、甘草10-15份。
2.一种如权利要求1所述的兽用清瘟解毒口服液的制备方法,其特征在于:包括以下步骤:
(1)按上述重量份比例取各中药原料,将中药原料粉碎;取中药原料总重量7-10倍重量的水加热至80-85℃,加入粉碎后的中药,恒温浸泡10-20分钟;然后将药液降温至45-50℃,调节pH至4.5-5.0,加入复合酶,搅拌均匀,酶解1-3h,然后升温至75-80℃进行酶灭活处理;所述复合酶为纤维素酶、果胶酶、淀粉酶的混合物,质量配比为,纤维素酶∶果胶酶∶淀粉酶=2-3∶1-2∶0.5-0.8;其中纤维素酶酶活以20000U/g计,用量不小于1.0g,果胶酶酶活以50000U/g计,用量不小于1.0g,淀粉酶酶活以30000U/g计,用量不小于1.0g;
(2)将步骤(1)酶解后药液煎煮两次,第一次加入药液重量5-8倍的水煎煮1-2h,第二次加入药渣重量5-7倍的水煎煮1-2h,过滤,将两次煎煮液合并;
(3)将合并后的煎煮液减压浓缩至相对密度为1.05-1.06,向减压浓缩后的药液中加入95%乙醇进行醇沉,过滤,往滤液中加入防腐剂苯甲酸钠2-5重量份、乳化剂吐温10-20重量份,搅匀,调节pH值至4.3-5.0,加蒸馏水定容至配制量,灌装、灭菌即得清瘟解毒口服液成品。
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