CN106110119A - 一种兽用清瘟解毒口服液及其制备方法 - Google Patents
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Abstract
本发明公开了一种兽用清瘟解毒口服液及其制备方法，包括以下重量份的原料：地黄25‑40份、栀子40‑60份、黄芩40‑50份、连翘30‑50份、玄参25‑40份、板蓝根30‑50份、金银花30‑50份、炙百部20‑30份、桑白皮20‑35份、重楼10‑15份、贯众10‑13份、甘草10‑15份。本发明的兽用清瘟解毒口服液，具有抗菌、抗病毒、扶正固体、清热解毒，补血活血、益气健脾，增进食欲，增进生长，提高机体免疫功能，对畜禽的瘟热毒症疗效独特，对由病毒或细菌引起的畜禽各类疾病均有显著疗效，而且不易沉淀；另外最大限度地提取出了中药的有效成分，提高经济效益。
Description
技术领域
本发明涉及兽用中药技术领域，尤其涉及一种兽用清瘟解毒口服液及其制备方法。
背景技术
目前《兽药地方标准升国家标准》第二册对清瘟解毒口服液的制备方法为：以制备1000mL口服液为例，将地黄150g、栀子250g、黄芩225g、连翘200g、玄参150g和板蓝根200g加水煎煮两次，合并煎液，静置，滤过，浓缩，滤过，加水至1000ml，灌装、灭菌即得。现有的清瘟解毒口服液通常组方简单，效果并不是很显著，而且存在静置存放易产生沉淀物的弊端。另外，传统工艺提取清瘟解毒口服液，往往提取效率较低，且有效成分的收率偏低，大量有效成分在植物细胞壁中没有释放到提取溶媒中，除杂效率低，且易损失较多的有效成分，大大降低了制备的经济效益。
发明内容
本发明的目的是克服现有技术的不足，提供一种兽用清瘟解毒口服液，以纯天然中兽药为成分，组方合理，具有抗菌、抗病毒、扶正固体、清热解毒，、补血活血、益气健脾，增进食欲，增进生长，提高机体免疫功能，对畜禽的瘟热毒症疗效独特，对由病毒或细菌引起的畜禽各类疾病均有显著疗效，可用于禽新城疫、法氏囊等病毒病以及病毒性呼吸道病、慢性呼吸道病等，而且解决目前中兽药口服液存放一段时间后易产生沉淀物的难题；另外用生物酶辅助提取药材中有效成分，提高药材有效成分的溶出率，最大限度地提取出了中药的有效成分，并很好的去除了中药提取液中的有害物质和杂质，绿色无污染，防腐保质效果好。
本发明的另一目的是提高该兽用清瘟解毒口服液的制备方法。
为了实现上述目的，本发明采用如下技术方案：
一种兽用清瘟解毒口服液，包括以下重量份的原料：地黄25-40份、栀子40-60份、黄芩40-50份、连翘30-50份、玄参25-40份、板蓝根30-50份、金银花30-50份、炙百部20-30份、桑白皮20-35份、重楼10-15份、贯众10-13份、甘草10-15份。
所述的兽用清瘟解毒口服液的制备方法，包括以下步骤：
(1)按上述重量份比例取各中药原料，将中药原料粉碎；取中药原料总重量7-10倍重量的水加热至80-85℃，加入粉碎后的中药，恒温浸泡10-20分钟；然后将药液降温至45-50℃，调节pH至4.5-5.0，加入复合酶，搅拌均匀，酶解1-3h，然后升温至75-80℃进行酶灭活处理；所述复合酶为纤维素酶、果胶酶、淀粉酶的混合物，质量配比为，纤维素酶∶果胶酶∶淀粉酶＝2-3∶1-2∶0.5-0.8；其中纤维素酶酶活以20000U/g计，用量不小于1.0g，果胶酶酶活以50000U/g计，用量不小于1.0g，淀粉酶酶活以30000U/g计，用量不小于1.0g；
(2)将步骤(1)酶解后药液煎煮两次，第一次加入药液重量5-8倍的水煎煮1-2h，第二次加入药渣重量5-7倍的水煎煮1-2h，过滤，将两次煎煮液合并；
(3)将合并后的煎煮液减压浓缩至相对密度为1.05-1.06，向减压浓缩后的药液中加入95％乙醇进行醇沉，过滤，往滤液中加入防腐剂苯甲酸钠2-5重量份、乳化剂吐温10-20重量份，搅匀，调节pH值至4.3-5.0，加蒸馏水定容至配制量，灌装、灭菌即得清瘟解毒口服液成品。
本发明中地黄、栀子、黄芩、连翘、玄参、板蓝根使常用的清瘟解毒药物组合，本发明保留原有组分，加入金银花、炙百部、桑白皮、重楼、贯众、甘草，可以大大提高本发明的药效。其中，炙百部：味甘润，性苦降，微温，归肺经，有润肺止咳，化浊解毒祛邪之效；桑白皮：味甘，性寒，归肺经。具有泻肺平喘，利水消肿的功效，用于肺热喘咳等症；重楼：苦，微寒,归肝经，有清热解毒，消肿止痛之功，本品苦寒入肝，尚有凉肝泄热作用；贯众：味苦，性微寒，归肝；胃经，具有清热、解毒、平肝之功效，用于风热感冒；金银花：味甘，性寒。归肺、心、胃经。具有清热解毒，疏散风热功效。用于风热感冒，温热发病；甘草：性平、味平、入心、肺、脾、胃经。有补脾益气、清热解毒、去痰止咳、缓急止痛、调和诸药之功效。
本发明的中药组合物具有清热解毒，清肺止嗽、利痰定喘的功能，清瘟解毒、凉血解表，可用于畜禽病毒性感冒、新城疫、类减蛋综合征、传染性法氏囊病、传支、传喉、细小病毒病、鸡痘等各种病毒性疾病或上呼吸道感染。
与已有技术相比，本发明的有益效果如下：
本发明的兽用清瘟解毒口服液，以纯天然中兽药为成分，组方合理，具有抗菌、抗病毒、扶正固体、清热解毒，、补血活血、益气健脾，增进食欲，增进生长，提高机体免疫功能，对畜禽的瘟热毒症疗效独特，对由病毒或细菌引起的畜禽各类疾病均有显著疗效，可用于禽新城疫、法氏囊等病毒病以及病毒性呼吸道病、慢性呼吸道病等，而且解决目前中兽药口服液存放一段时间后易产生沉淀物的难题；另外用生物酶辅助提取药材中有效成分，提高药材有效成分的溶出率，最大限度地提取出了中药的有效成分，并很好的去除了中药提取液中的有害物质和杂质，绿色无污染，防腐保质效果好。
具体实施方式
以下结合实施例对本发明作进一步的说明，但本发明不仅限于这些实施例，在未脱离本发明宗旨的前提下，所作的任何改进均落在本发明的保护范围之内。
实施例1：
一种兽用清瘟解毒口服液，包括以下重量份的原料：地黄25份、栀子50份、黄芩45份、连翘40份、玄参30份、板蓝根40份、金银花40份、炙百部25份、桑白皮30份、重楼15份、贯众10份、甘草10份。
所述的兽用清瘟解毒口服液的制备方法，包括以下步骤：
(1)按上述重量份比例取各中药原料，将中药原料粉碎；取中药原料总重量7倍重量的水加热至85℃，加入粉碎后的中药，恒温浸泡10分钟；然后将药液降温至45℃，调节pH至4.5，加入复合酶，搅拌均匀，酶解3h，然后升温至75℃进行酶灭活处理；所述复合酶为纤维素酶、果胶酶、淀粉酶的混合物，质量配比为，纤维素酶∶果胶酶∶淀粉酶＝2∶1∶0.5；其中纤维素酶酶活以20000U/g计，用量不小于1.0g，果胶酶酶活以50000U/g计，用量不小于1.0g，淀粉酶酶活以30000U/g计，用量不小于1.0g；
(2)将步骤(1)酶解后药液煎煮两次，第一次加入药液重量5倍的水煎煮2h，第二次加入药渣重量5倍的水煎煮2h，过滤，将两次煎煮液合并；
(3)将合并后的煎煮液减压浓缩至相对密度为1.05，向减压浓缩后的药液中加入95％乙醇进行醇沉，过滤，往滤液中加入防腐剂苯甲酸钠2重量份、乳化剂吐温10重量份，搅匀，调节pH值至4.3，加蒸馏水定容至配制量，灌装、灭菌即得清瘟解毒口服液成品。
实施例2：
一种兽用清瘟解毒口服液，包括以下重量份的原料：地黄40份、栀子60份、黄芩40份、连翘50份、玄参25份、板蓝根50份、金银花50份、炙百部20份、桑白皮20份、重楼15份、贯众13份、甘草15份。
所述的兽用清瘟解毒口服液的制备方法，包括以下步骤：
(1)按上述重量份比例取各中药原料，将中药原料粉碎；取中药原料总重量10倍重量的水加热至85℃，加入粉碎后的中药，恒温浸泡20分钟；然后将药液降温至50℃，调节pH至4.5，加入复合酶，搅拌均匀，酶解3h，然后升温至80℃进行酶灭活处理；所述复合酶为纤维素酶、果胶酶、淀粉酶的混合物，质量配比为，纤维素酶∶果胶酶∶淀粉酶＝3∶2∶0.8；其中纤维素酶酶活以20000U/g计，用量不小于1.0g，果胶酶酶活以50000U/g计，用量不小于1.0g，淀粉酶酶活以30000U/g计，用量不小于1.0g；
(2)将步骤(1)酶解后药液煎煮两次，第一次加入药液重量8倍的水煎煮1h，第二次加入药渣重量7倍的水煎煮2h，过滤，将两次煎煮液合并；
(3)将合并后的煎煮液减压浓缩至相对密度为1.06，向减压浓缩后的药液中加入95％乙醇进行醇沉，过滤，往滤液中加入防腐剂苯甲酸钠5重量份、乳化剂吐温20重量份，搅匀，调节pH值至5.0，加蒸馏水定容至配制量，灌装、灭菌即得清瘟解毒口服液成品。
Claims (2)
1.一种兽用清瘟解毒口服液，其特征在于：包括以下重量份的原料：地黄25-40份、栀子40-60份、黄芩40-50份、连翘30-50份、玄参25-40份、板蓝根30-50份、金银花30-50份、炙百部20-30份、桑白皮20-35份、重楼10-15份、贯众10-13份、甘草10-15份。
2.一种如权利要求1所述的兽用清瘟解毒口服液的制备方法，其特征在于：包括以下步骤：
(1)按上述重量份比例取各中药原料，将中药原料粉碎；取中药原料总重量7-10倍重量的水加热至80-85℃，加入粉碎后的中药，恒温浸泡10-20分钟；然后将药液降温至45-50℃，调节pH至4.5-5.0，加入复合酶，搅拌均匀，酶解1-3h，然后升温至75-80℃进行酶灭活处理；所述复合酶为纤维素酶、果胶酶、淀粉酶的混合物，质量配比为，纤维素酶∶果胶酶∶淀粉酶＝2-3∶1-2∶0.5-0.8；其中纤维素酶酶活以20000U/g计，用量不小于1.0g，果胶酶酶活以50000U/g计，用量不小于1.0g，淀粉酶酶活以30000U/g计，用量不小于1.0g；
(2)将步骤(1)酶解后药液煎煮两次，第一次加入药液重量5-8倍的水煎煮1-2h，第二次加入药渣重量5-7倍的水煎煮1-2h，过滤，将两次煎煮液合并；
(3)将合并后的煎煮液减压浓缩至相对密度为1.05-1.06，向减压浓缩后的药液中加入95％乙醇进行醇沉，过滤，往滤液中加入防腐剂苯甲酸钠2-5重量份、乳化剂吐温10-20重量份，搅匀，调节pH值至4.3-5.0，加蒸馏水定容至配制量，灌装、灭菌即得清瘟解毒口服液成品。
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