CN106109625B - A kind of preparation method of Chinese medicine preparation for heart failure treatment - Google Patents

A kind of preparation method of Chinese medicine preparation for heart failure treatment Download PDF

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CN106109625B
CN106109625B CN201610629385.7A CN201610629385A CN106109625B CN 106109625 B CN106109625 B CN 106109625B CN 201610629385 A CN201610629385 A CN 201610629385A CN 106109625 B CN106109625 B CN 106109625B
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medicinal extract
radix
preparation
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CN106109625A (en
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吴伦
苏阳
刘莉
谢宁
田振坤
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Heilongjiang University of Chinese Medicine
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/296—Epimedium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K2236/30—Extraction of the material
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    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The present invention relates to a kind of preparation methods of the Chinese medicine preparation for heart failure treatment, belong to the field of Chinese medicines.It is as follows：(1) Radix Astragali, cassia twig, Herba Epimedii, Poria cocos, lepidium seed, Rhizoma Atractylodis Macrocephalae, motherwort, hairyvein agrimony and Radix Glycyrrhizae are weighed；After proportioning crushing, respectively with the water refluxing extractions of 8 10 times of amounts, 8 10 times of amounts and 8 10 times of amounts three times, extraction time is every time 2h, and medicinal extract 1 is recovered under reduced pressure to obtain in filtering and merging filtrate；(2) weigh 15g Radix Salviae Miltiorrhizaes to extract at 80 DEG C using 80% ethyl alcohol of 10 times of amounts, 10 times of amounts and 8 times of amounts, medicinal extract 2 is recovered under reduced pressure to obtain in time 2h；(3) radix pseudostellariae 20g is weighed, fine powder is worn into and crosses 200 mesh sieves；Medicinal extract 1 and medicinal extract 2 is taken to be dried in vacuo to obtain dry powder, radix pseudostellariae fine powder and extract dry powder are mixed to obtain Chinese medicine composition, and are mixed with the auxiliary material of corresponding parts by weight by mixing, and 60% appropriate amount of ethanol is added to pelletize, dry, filling capsule to get.

Description

A kind of preparation method of Chinese medicine preparation for heart failure treatment
Technical field
The present invention relates to a kind of preparation methods of the Chinese medicine preparation for heart failure treatment, belong to the field of Chinese medicines.
Background technology
Heart failure is since any cardiac structure or dysfunction cause ventricular filling or penetrate that blood ability is damaged one group Complex clinical syndrome, main clinical manifestation is expiratory dyspnea and activity tolerance is limited and fluid retention (pulmonary venous pleonaemia and outer All oedema).In heart failure last stage for various heart diseases serious and eventually, incidence is high, be current most important cardiovascular disease it One.
Heart failure is a name of disease using pathophysiological change as foundation of modern medicine, is had no in traditional Chinese medical science traditional literature This name, but according to its clinical manifestation and its feature, it is no lack of the description and spy to heart failure in thousands of years of historical development Rope, heart failure belong to the disease categories such as the traditional Chinese medical science " palpitaition ", " dyspnea ", " phlegm and retained fluid ", " oedema ", " obstruction of qi in the chest " more.
Ginseng stilbene invigorating heart side is the clinical experience side of Heilongjiang University of Chinese Medicine Liu Li professors, and professor Liu Li refers to ancient books, root According to clinical experience for many years, induction and conclusion, for heart failure etiology and pathogenesis, it is proposed that the therapeutic rules of " QI invigorating Wen Yang, activating blood and promoting diuresis ", Ginseng stilbene invigorating heart side is formed according to accordingly prescription.Prescription：20 parts of Radix Astragali, 20 parts of radix pseudostellariae, 10 parts of cassia twig, 15 parts of Herba Epimedii, Poria cocos 10 parts of 20 parts, 15 parts of lepidium seed, 15 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Radix Salviae Miltiorrhizae, 15 parts of motherwort, 30 parts of hairyvein agrimony and Radix Glycyrrhizae.Radix pseudostellariae in side, Radix Astragali is monarch drug in a prescription, QI invigorating Wen Yang；Radix aconiti lateralis preparata warms up soil with warm kidney, with aid yang qi；Cassia twig can help radix aconiti lateralis preparata yang-tonic tongmai, moreover it is possible to flat It spins inverse, treats " dyspnea and expectoration "；Radix Salviae Miltiorrhizae Li Shui promoting blood circulation and removing blood stasis to control its mark, close and regulating fluid apssage by the heap soil or fertilizer over and around the roots that lepidium seed lets out lung qi, Lower gas is relievingd asthma；Radix Glycyrrhizae is with coordinating the drug actions of a prescription.
Although ginseng stilbene invigorating heart side clinically obtains the effect of splendid, since it is traditional Chinese medicine decoction, cause Patient is inconvenient for use, and the stability of decoction is bad, is unfavorable for joining the popularization and clinical practice of stilbene invigorating heart side.
The content of the invention
An object of the present invention is to provide a kind of preparation method of the Chinese medicinal capsule preparation for heart failure treatment, specific to walk It is rapid as follows：
(1) weigh Radix Astragali 20g, cassia twig 10g, Herba Epimedii 15g, Poria cocos 20g, lepidium seed 15g, Rhizoma Atractylodis Macrocephalae 15g, motherwort 15g, Hairyvein agrimony 30g and Radix Glycyrrhizae 10g；After being crushed by proportioning, measured respectively with 8-10 times, 8-10 times measure and water refluxing extraction that 8-10 times is measured Three times, extraction time is every time 2h, filters simultaneously merging filtrate, medicinal extract 1 is recovered under reduced pressure to obtain；
(2) weigh 15g Radix Salviae Miltiorrhizaes to extract at 80 DEG C using 80% ethyl alcohol of 10 times of amounts, 10 times of amounts and 8 times of amounts, the time For 2h, medicinal extract 2 is recovered under reduced pressure to obtain；
(3) radix pseudostellariae 20g is weighed, fine powder is worn into and crosses 200 mesh sieves；It takes medicinal extract 1 and medicinal extract 2 is dried in vacuo to obtain dry powder, mixing, Radix pseudostellariae fine powder and extract dry powder are mixed into obtain Chinese medicine composition, and mixed with the auxiliary material of corresponding parts by weight, 60% ethyl alcohol is added to fit Amount granulation, it is dry, filling capsule to get.
In one embodiment, the auxiliary material is selected from starch, beta-cyclodextrin, carbomer, microcrystalline cellulose, hydroxypropyl first Base cellulose, low-substituted hydroxypropyl cellulose, calcium carboxymethylcellulose, polyethylene glycol (PEG), vitamin E polyethylene glycol amber Acid esters, sodium carboxymethylcellulose, methylcellulose, ethyl cellulose, mannitol, lauryl sodium sulfate, cross-linked carboxymethyl are fine The plain sodium of dimension, lactose, polyvinylpyrrolidone (PVP), crosslinked polyvinylpyrrolidone, magnesium stearate, talcum powder, superfine silica gel powder, One or more of Aspartame, orange flavor, sodium acid carbonate, sodium carbonate.The auxiliary material used and preparation method of above-mentioned preparation Its conventional auxiliary material can be used and preparation method is made.
In one embodiment, the weight ratio of the Chinese medicine composition and auxiliary material is 10: 0.6.
In another embodiment, the auxiliary material is microcrystalline cellulose, vitamin E polyethylene glycol succinic acid ester and A Ba This sweet tea, the weight ratio of three is 1: 0.1~0.4: 0.2.
In one specifically embodiment, the auxiliary material for microcrystalline cellulose, vitamin E polyethylene glycol succinic acid ester and Abbas's sweet tea, the weight ratio of three is 1: 0.3: 0.2.
The present invention gropes to have obtained supplementary product kind, the preferred plan with when dosage by a large number of experiments research, in use Stating auxiliary material can overcome the problems, such as that Chinese medicinal capsule preparation influences medicine stability due to hygroscopicity, prepared by preparation method of the present invention Chinese medicinal capsule preparation greatly improves the stability of said preparation.
Specific embodiment
Can also the present invention further be understood by embodiment, wherein the embodiment illustrates some preparations or user Method.It is to be appreciated, however, that these embodiments do not limit the present invention.The change of the present invention of currently known or further exploitation Change is considered within the scope of the invention described herein and claimed below.
The preparation of 1 Chinese medicinal capsule of embodiment
(1) weigh Radix Astragali 20g, cassia twig 10g, Herba Epimedii 15g, Poria cocos 20g, lepidium seed 15g, Rhizoma Atractylodis Macrocephalae 15g, motherwort 15g, Hairyvein agrimony 30g and Radix Glycyrrhizae 10g；After being crushed by proportioning, respectively with the water refluxing extraction of 10 times of amounts, 10 times of amounts and 8 times of amounts three times, carry It is every time 2h to take the time, filters simultaneously merging filtrate, medicinal extract 1 is recovered under reduced pressure to obtain；
(2) weigh 15g Radix Salviae Miltiorrhizaes to extract at 80 DEG C using 80% ethyl alcohol of 10 times of amounts, 10 times of amounts and 8 times of amounts, the time For 2h, medicinal extract 2 is recovered under reduced pressure to obtain；
(3) radix pseudostellariae 20g is weighed, fine powder is worn into and crosses 200 mesh sieves；It takes medicinal extract 1 and medicinal extract 2 is dried in vacuo to obtain dry powder, mixing, By radix pseudostellariae fine powder and microcrystalline cellulose, vitamin E polyethylene glycol succinic acid ester and the A Ba of extract dry powder and corresponding parts by weight This sweet tea (it is counted by Chinese medicine composition and auxiliary material weight ratio 10: 0.6, addition auxiliary material amount is 2.2g, and the weight ratio of three is 1: 0.3: 0.2) mix, 60% appropriate amount of ethanol is added to pelletize, dry, filling capsule is to get (300mg/).
2 Chinese medicinal capsule study on the stability of embodiment
Correlated samples stability is investigated according to the stability guideline of 2010 editions two annex of Chinese Pharmacopoeia, is investigated respectively 25 DEG C place 36 months, 45 DEG C and relative humidity 75% under the conditions of place the medicine stability of 120 days.It is surveyed using HPLC methods Determine the content of Astragaloside IV and tanshin polyphenolic acid B in Chinese medicinal capsule.
25 DEG C place 36 months after each group effective component of chinese medicine content (n=10)
Comparative example 1 is that microcrystalline cellulose in auxiliary material is replaced with hydroxypropyl methyl cellulose, other auxiliary materials and method are the same as real Apply example 1；
Comparative example 2 is that microcrystalline cellulose in auxiliary material is replaced with lactose, other auxiliary materials and method are the same as embodiment 1；
Comparative example 3 is that vitamin E polyethylene glycol succinic acid ester in auxiliary material is replaced with Macrogol 4000, other auxiliary materials and Method is the same as embodiment 1；
Comparative example 4 is that the weight ratio of Chinese medicine composition and auxiliary material is 10: 1, other auxiliary materials and method are the same as embodiment 1.
Each group effective component of chinese medicine content (n=10) after being placed 60 days under the conditions of 45 DEG C and relative humidity 75%
3 Chinese medicinal capsule preparation contents particles angle of repose of embodiment measures
Using fixed funnel method, (Xi Nianzhu is edited《Pharmacy》The third edition) measure the filling preceding particle of sample angle of repose, and And the content uniformity of sample is measured according to the lower pertinent regulations of annex I L of Chinese Pharmacopoeia 2010 editions.
Present invention merely illustrates some claimed specific embodiments, one of them or more skill Recorded technical characteristic can be combined with arbitrary one or more technical solutions in art scheme, these are combined and obtain Technical solution also in the application protection domain, technical solution is disclosed in the present invention just as obtained from these are combined It is specifically recorded in content the same.

Claims (1)

1. a kind of preparation method of Chinese medicinal capsule preparation for heart failure treatment, is as follows：
（1）Weigh Radix Astragali 20g, cassia twig 10g, Herba Epimedii 15g, Poria cocos 20g, lepidium seed 15g, 15 g of Rhizoma Atractylodis Macrocephalae, 15 g of motherwort, celestial being 10 g of crane grass 30 g and Radix Glycyrrhizae；After being crushed by proportioning, measured respectively with 8-10 times, 8-10 times measure and water refluxing extraction that 8-10 times is measured Three times, extraction time is every time 2h, filters simultaneously merging filtrate, medicinal extract 1 is recovered under reduced pressure to obtain；
（2）It weighs 15g Radix Salviae Miltiorrhizaes to extract at 80 DEG C using 80% ethyl alcohol of 10 times of amounts, 10 times of amounts and 8 times of amounts, time 2h, Medicinal extract 2 is recovered under reduced pressure to obtain；
（3）Radix pseudostellariae 20g is weighed, fine powder is worn into and crosses 200 mesh sieves；Medicinal extract 1 and medicinal extract 2 is taken to be dried in vacuo to obtain dry powder, mixing will too Son ginseng fine powder and extract dry powder mix to obtain Chinese medicine composition, and are mixed with the auxiliary material of corresponding parts by weight, add 60% appropriate amount of ethanol system Grain, it is dry, filling capsule to get；The weight ratio of the Chinese medicine composition and auxiliary material is 10:0.6；The auxiliary material is microcrystalline cellulose Element, vitamin E polyethylene glycol succinic acid ester and Abbas's sweet tea, the weight ratio of three is 1：0.3：0.2.
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1927331A (en) * 2006-01-25 2007-03-14 宋春光 Chinese medicine preparation for curing chronic heart failure

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JP2005281278A (en) * 2004-03-31 2005-10-13 Daicho Kikaku:Kk Nutrient, digestive organ agent, antidepressant, climacteric disorder agent, anti-senile dementia agent, anti-alzheimer agent, muscle reinforcing agent and anti-inflammatory agent

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1927331A (en) * 2006-01-25 2007-03-14 宋春光 Chinese medicine preparation for curing chronic heart failure

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* Cited by examiner, † Cited by third party
Title
参芪益心方对CHF大鼠心肌细胞凋亡指数及Bax、Bcl-2表达的影响;金娟等;《山东中医杂志》;20140531;第33卷(第5期);第388-390页，尤其是第388页摘要末句、第389页右栏第1.2节 *

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