CN106109517A - A kind of white externally used antimicrobial spray-filming agent and preparation method thereof - Google Patents
A kind of white externally used antimicrobial spray-filming agent and preparation method thereof Download PDFInfo
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- CN106109517A CN106109517A CN201610717745.9A CN201610717745A CN106109517A CN 106109517 A CN106109517 A CN 106109517A CN 201610717745 A CN201610717745 A CN 201610717745A CN 106109517 A CN106109517 A CN 106109517A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
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Abstract
The present invention relates to medical care, disclose a kind of white externally used antimicrobial spray-filming agent and preparation method thereof.White spray-filming agent disclosed by the invention includes white extract, film former, plasticizer and solvent.The preparation method of white spray-filming agent disclosed by the invention comprises the following steps: white extract, film former, plasticizer and solvent are mixed, and regulates pH to 6.0～7.5, prepares product.The antibacterial spray-filming agent of the present invention possesses good film property, safety non-toxic, and has that preparation technology is simple, sterilizing ability strong, carries and the feature such as convenient transportation.
Description
Technical field
The present invention relates to medical care, particularly to white spray-filming agent of one and preparation method thereof.
Background technology
Bacterial skin and soft tissue primary infection mainly have impetigo, furuncle, carbuncle, hidradenitis suppurativa and honeycomb group
Knitting inflammation, local treatment is the important measures treating this kind of disease.But most antibacterials create one to clinical common antibiotics
Fixed drug resistance, the such as staphylococcus aureus of China's most area are more than 90% to Penicillin-resistant rate, to red mould
Element is 80.2%, is 59.5% to clindamycin, to the drug resistance of tetracycline, chloromycetin, gentamycin and ciprofloxacin successively
It is 34.8%, 7.7%, 4.5% and 1.8%.
Because antibiotic has the advantages that easily produce drug resistance, use skin that antibiotic therapy antibacterial causes, soft group
Knitting infection and easily cause secondary infection, long-term efficacy is undesirable, causes Relapse rate to show effect, thus limits its actual application.
Therefore, researching and developing a kind of new anti-infection effect excellent, long-term efficacy significant local topical medicine is that those skilled in the art need
Solve the technical problem that.
Summary of the invention
In view of this, the invention discloses a kind of ultrawhite spray-filming agent and preparation method thereof, described white externally used antimicrobial
Spray-filming agent has good antibacterial effect.
The technical solution used in the present invention is as follows:
The invention discloses a kind of white spray-filming agent, by mass percentage, above-mentioned white spray-filming agent includes following components:
The summation of described white extract, filmogen, plasticizer and solvent quality ratio is 100%.
Preferably, described white extract is white ethanol extraction, white petroleum ether extract and white chloroform
The mixture of one or more in extract.Described white petroleum ether extract and white chloroform extract are by described Baiyi
Alcohol extraction thing is refining to obtain further.
Preferably, described film former be chitosan, chitosan hydrochlorate, carboxymethyl chitosan, polyvinylpyrrolidone,
One or more in acid fiber by polylactic, polyvinyl alcohol, hydroxypropyl methyl cellulose and hydroxypropyl cellulose.Film former can make medicine
Liquid forms a fine and close film, stops extraneous antibacterial and the entrance of dust, and maintenance wound circumference one is moistening, the environment of health.
Preferably, described plasticizer is the one in glycerol, propylene glycol, sorbitol, Polyethylene Glycol and Tween 80 or many
Kind.Plasticizer can make film system good toughness, smooth surface, and has certain tensile strength.
Preferably, described solvent is the mixture of dehydrated alcohol and water.
The invention also discloses the preparation method of described white spray-filming agent, comprise the following steps:
White extract, filmogen, plasticizer and solvent being mixed, regulation pH is 6.0～7.5, prepares product.
In white spray-filming agent component disclosed by the invention is a kind of medicinal and edible plant in vain, has gone up a century in China
History, be distributed mainly on the areas such as south China, southwest, Central China, change containing phenols, total flavones, total saponins, volatile oil and polysaccharide etc.
Study point.In recent years, domestic and international dialogue has carried out the research of deep effective substance, safety and application and development, card
Real dish has antioxidation, antibacterial, antiinflammatory and analgesia, antitumor, protection gastric mucosa, improves cognitive disorder, antidepressant and anti-Jiao
The medical values such as worry.About in vain in the application of department of dermatologry, dish can control traumatic injury, furuncle swells pus infections etc. in ancient Chinese prose record.Its
In " the SHENGCAO property of medicine standby will " record " root mashes deposited skin ulcer with Herbia Wedeliae, washes rotten foot and also imitates "；" classifying herbal " is recorded and " controls traumatic injury to damage
Wound, leucorrhea, bones and muscles pain, rheumatic numbness "；" vegetation just side " records and " except rheumatism, controls muscles and bones contracture, waist knee joint impairment caused by overstrain, dissipate and fall the damage stasis of blood
Blood ", the most also have pertinent literature study white antiinflammatory spray, transparent toilet soap, the preparation of toothpaste with fluoride, show white have good
Good antibacterial effect.
Active component in white spray-filming agent disclosed by the invention derives from medicinal and edible plant, thus it is hidden to reduce safety
Suffering from, high degree avoids consumer irritant reaction occur, and antibacterial activity is good simultaneously, is suitable for wound post processing.Film former of the present invention
Ethanol in middle chitosan compounds and solvent also has bactericidal action, can improve white spray-filming agent under specific proportioning
Bacteriostasis efficacy.
The preparation technology of white spray-filming agent disclosed by the invention is simple, has only to when deployed be sprayed onto wound circumference,
Causing medicinal liquid to form a fine and close film, this film contains the antibacterial that can kill wound circumference, can stop extraneous antibacterial simultaneously
With the entrance of dust, maintenance wound circumference one is moistening, the environment of health, beneficially wound healing.It addition, as a kind of medicine food
Homologous plant, although have the edible medicinal history of centuries in vain, but the present invention be first using white extract as antibacterial spray
Active component in membrane, is expected to improve most antibacterial using white extract as new Antibacterial Constituents normal to clinic
The present situation of drug resistance is produced with antibiotic.Because there being the one-tenth in the edible of centuries and medicinal history, and instant component in vain
Membrane and plasticizer belong to common composition in marketed drugs, rather than newly added composition, numerous pharmacological researches be shown as membrane and
The safe toxic and side effects of plasticizer is little, thus the safety of this spray-filming agent is higher.
In sum, the sterilizing ability toxic and side effects strong, safe of white spray-filming agent disclosed by the invention is little, after being suitable for wound
Process.And the preparation technology of the white spray-filming agent of the present invention is simple, can carry out at normal temperatures and pressures, beneficially popularization and application, can answer
For every field such as biological, medicine and chemical industry.
Accompanying drawing explanation
In order to be illustrated more clearly that the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
In having technology to describe, the required accompanying drawing used is briefly described, it should be apparent that, the accompanying drawing in describing below is only this
Some embodiments of invention, for those of ordinary skill in the art, on the premise of not paying creative work, it is also possible to
Other accompanying drawing is obtained according to these accompanying drawings.
Fig. 1 is the petroleum ether extract antibacterial tests result figure of the white ethanol extraction of the embodiment of the present invention；
Fig. 2 is the chloroform extract antibacterial tests result figure of the white ethanol extraction of the embodiment of the present invention.
Detailed description of the invention
The invention discloses a kind of white spray-filming agent and its preparation method and application, white spray-filming agent disclosed by the invention has
There is the strongest sterilizing ability.Those skilled in the art can use for reference present disclosure, is suitably modified technological parameter and realizes.Need especially
It is noted that all similar replacements and change apparent to those skilled in the art, they are considered as bag
Include in the present invention.Method and the application of the present invention are described by preferred embodiment, and related personnel substantially can be not
In disengaging present invention, spirit and scope, method described herein and application it is modified or suitably changes and combine, coming
Realize and application the technology of the present invention.
Below in conjunction with embodiment, the present invention is expanded on further.
The raw material used in the embodiment of the present invention or reagent are commercially available or self-control source.
Embodiment 1 prepares white antibacterial spray-filming agent
Preparation method:
(1), after white fresh stem and leaf drying being pulverized, 100g white lead is taken, with 95% ethanol proportionally 1:10 (w/
V) 24h is soaked in mixing, continues to soak filtering residue 24h after filtration, and above immersion process is carried out 3 times altogether, united extraction liquid, concentrating under reduced pressure
And it is dried under vacuum to constant weight, obtain white ethanol extraction extractum；
(2) hydroxypropyl cellulose of accurate weighed recipe quantity and hydroxypropyl methyl cellulose, be sequentially added into appropriate purified water
In, make it dissolve under magnetic agitation, the Polyethylene Glycol adding above-mentioned recipe quantity stirs evenly；The polyethylene of another accurately weighed recipe quantity
Ketopyrrolidine, white ethanol extraction add dissolving in 150mL dehydrated alcohol；After above-mentioned each solution mix homogeneously, add purification
Water, to 500g, is adjusted pH to be 6.5 with the NaOH that concentration mass fraction is 12%, in the spray bottle of subpackage medicinal liquid to sterilization treatment, is made
Used time, the shower nozzle alignment affected part of spray bottle is sprayed, sprays medicinal liquid fast filming.
Embodiment 2 prepares white antibacterial spray-filming agent
Preparation method:
(1) utilizing supercritical extraction to obtain white ethanol extraction, the white leaf dried powder first weighing 10g is placed in extraction
Taking in still, using dehydrated alcohol as entrainer, arranging extracting pressure is 20MPa, and extraction temperature is 35 DEG C, CO2Flow is 20L/
H, collects extracting solution after extraction time 1h, concentrating under reduced pressure is also dried under vacuum to constant weight, obtains white ethanol extraction extractum；
(2) white for 10g ethanol extraction extractum is made ethanol solution agent, by the chitosan of above-mentioned content, polyvinyl alcohol,
Hydroxypropyl methyl cellulose, propylene glycol and glycerol add in solution after mix homogeneously, add purified water to 500g, use concentration matter
Amount mark is the NaHCO of 15%3Adjusting pH is 7.0, subpackage after the assay was approved.
Embodiment 3 prepares white antibacterial spray-filming agent
Preparation method:
(1) after white fresh stem and leaf drying being pulverized, white lead and 40% ethanol proportionally 1:15 (w/v) mixing,
Ultrasonic intermittent extraction 2 times, each 30min, ultrasonic power 100W, united extraction liquid, evaporated under reduced pressure to constant weight obtains Baiyi alcohol
Extract extractum；
(2) take the ethanol extraction extractum that said method obtains to be suspended in water, add petroleum ether by the volume ratio of 1:1,
Mixing 10 times up and down, collect petroleum ether layer extract after standing 1 hour, above extraction process is carried out 3 times altogether, the stone that will collect
Oil ether layer extract concentrating under reduced pressure is also dried under vacuum to constant weight, obtains petroleum ether extract extractum；
(3) carboxymethyl chitosan, chitosan hydrochlorate and the hydroxypropyl cellulose of accurate weighed recipe quantity, is sequentially added into
In 50mL purified water, under magnetic agitation, make it dissolve, add the Tween 80 of recipe quantity, stir 10-30min, mix to solution
Uniformly；The petroleum ether extract extractum of the white ethanol extraction of another accurately weighed recipe quantity adds in 150mL dehydrated alcohol molten
Solve；After above-mentioned each solution mix homogeneously, add purified water to 500g, adjust pH to be 6.5 with the NaOH that concentration mass fraction is 15%,
The solid residue being filtered to remove in solution, through cobalt-60 irradiation-sterilize, subpackage after the assay was approved.
Embodiment 4 prepares white antibacterial spray-filming agent
Preparation method:
(1), after white fresh stem and leaf drying being pulverized, white lead end is mixed with 35% ethanol proportionally 1:20 (w/v)
Close, water-bath heats 80 DEG C of backflow 2h, supersound process 5 minutes, lets cool, shake up, filter to obtain extracting solution, concentrating under reduced pressure vacuum
It is dried to constant weight, obtains white ethanol extraction extractum；
(2) take the ethanol extraction that said method obtains to be suspended in water, add petroleum ether by the volume ratio of 1:1, up and down
Mixing 10 times, collect petroleum ether layer extract after standing 1 hour, above extraction process is carried out 3 times altogether, the petroleum ether that will collect
Layer extract concentrating under reduced pressure is also dried under vacuum to constant weight, obtains petroleum ether extract extractum；
(3) water layer suspended matter is obtained after isolating petroleum ether layer extract according to (2) from white ethanol extraction, by 1:
The volume ratio of 1 adds chloroform, up and down mixing 10 times, collects chloroform layer extract after standing 1 hour, and above extraction process is carried out altogether
3 times, by the chloroform layer extract concentrating under reduced pressure collected and be dried under vacuum to constant weight, obtain chloroform extract extractum；
(4) the chloroform extract extractum after extracting adds auxiliary materials and mixing, makes medicinal liquid, adds purified water to 500g, uses concentration
Mass fraction be 10% NaOH adjust pH be 7.5, subpackage after the assay was approved.
Embodiment 5 antibacterial tests
Petroleum ether extract extractum and the embodiment 4 of white ethanol extraction prepared by embodiment 3 are prepared by the present embodiment
The in-vitro antibacterial effect of chloroform extract extractum of white ethanol extraction, measure minimum inhibitory concentration (MIC).With chromatographic grade
Ciprofloxacin as positive control, the petroleum ether extract extractum of white ethanol extraction to be measured, chloroform extract extractum with
And ciprofloxacin all dissolves, with the dimethyl sulfoxide with testing sample equivalent as negative control with dimethyl sulfoxide (DMSO).Examination
Proved recipe case is as follows:
The petroleum ether extract extractum of white ethanol extraction to be measured and the Concentraton gradient of chloroform extract extractum are joined
Be made as 1280,640,320,160,80,40,20,10,5ug/mL；The Concentraton gradient of ciprofloxacin is formulated as 32,16,8,4,
2、1、0.5、0.25、0.125ug/mL。
By testing sample, positive control sample and the negative control sample of each concentration respectively with staphylococcus aureus, sand
Door Salmonella, escherichia coli, Bacillus cercus, White staphylococcus, bacillus subtilis and micrococcus luteus mixing, after sealing
Put in 37 DEG C of normal air incubators, hatch 16～20h, the result obtained such as table 1, Fig. 1 and Fig. 2.Fig. 1 is white ethanol extraction
The bacteriostatic test result of petroleum ether extract extractum, Fig. 2 is the antibacterial examination of the chloroform extract extractum of white ethanol extraction
Test result.
Table 1 minimum inhibitory concentration (MIC) measurement result
From table 1, Fig. 1 and Fig. 2 result it can be seen that the petroleum ether extract extractum of white ethanol extraction and chloroform extraction
Take thing extractum and 8 kinds of common antibacterials are all had obvious bacteriostasis, wherein, best to the fungistatic effect of Sharpe door bacterium；To large intestine
The fungistatic effect of angstrom uncommon bacterium, White staphylococcus, staphylococcus aureus and Bacillus cercus takes second place.Because Baiyi alcohol extraction
Petroleum ether extract extractum and the chloroform extract extractum of thing are the most effective in cure to infecting while various bacteria, and due to antibacterial pair
The white drug resistance that do not produces, therefore, the skin disease that white antimicrobial spray disclosed by the invention can infect with long-term treatment antibacterial
Sick.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (7)
1. a white spray-filming agent, it is characterised in that by mass percentage, including following components:
The summation of described white extract, filmogen, plasticizer and solvent quality ratio is 100%.
White spray-filming agent the most according to claim 1, it is characterised in that described white extract is Baiyi alcohol extraction
One or more in thing, white petroleum ether extract and white chloroform extract.
The preparation method of white spray-filming agent the most according to claim 1, it is characterised in that described film former be chitosan,
Chitosan hydrochlorate, carboxymethyl chitosan, polyvinylpyrrolidone, acid fiber by polylactic, polyvinyl alcohol, hydroxypropyl methyl cellulose
With one or more in hydroxypropyl cellulose.
The whitest spray-filming agent, it is characterised in that described plasticizer is glycerol, propylene glycol, Pyrusussuriensis
One or more in alcohol, Polyethylene Glycol and Tween 80.
The whitest spray-filming agent, it is characterised in that described solvent is the mixing of dehydrated alcohol and water
Thing.
6. the preparation method of the white spray-filming agent described in claim 1 to 5 any one, it is characterised in that comprise the following steps:
White extract, film former, plasticizer and solvent are mixed, regulates pH to 6.0～7.5, prepare product.
7. the preparation method of the white spray-filming agent described in claim 6, it is characterised in that described white extract by extraction,
Reflux extraction, microwave assisting method, ultrasonic wave added method and supercritical CO2Prepared by one or more extracting method in extraction
Obtain.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106580927A (en) * | 2017-02-17 | 2017-04-26 | 中国药科大学 | Ciclopirox olamine film-spraying agent and preparation method thereof |
| CN107412297A (en) * | 2017-07-12 | 2017-12-01 | 浙江理工大学 | A kind of ultrasonic cell disintegration extraction process of Bai le leaf total polyphenols |
| CN107519151A (en) * | 2017-09-06 | 2017-12-29 | 广西信业生物技术有限公司 | A kind of liquid bandage and preparation method thereof |
| CN108143985A (en) * | 2018-02-28 | 2018-06-12 | 苏州凌科特新材料有限公司 | A kind of medical more skin biology film forming spray and preparation method thereof |
| CN110680879A (en) * | 2019-11-08 | 2020-01-14 | 西安千禾药业股份有限公司 | Traditional Chinese medicine film spraying agent for promoting blood circulation, stopping bleeding, removing necrotic tissue and promoting granulation and preparation method thereof |
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| CN104586753A (en) * | 2015-02-04 | 2015-05-06 | 中国药科大学 | Carboxymethyl chitosan antibacterial film spray and preparation method thereof |
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| CN104586753A (en) * | 2015-02-04 | 2015-05-06 | 中国药科大学 | Carboxymethyl chitosan antibacterial film spray and preparation method thereof |
| CN105169128A (en) * | 2015-09-09 | 2015-12-23 | 陈红 | Traditional Chinese medicine spraying film agent for treating bacterial bedsore and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106580927A (en) * | 2017-02-17 | 2017-04-26 | 中国药科大学 | Ciclopirox olamine film-spraying agent and preparation method thereof |
| CN107412297A (en) * | 2017-07-12 | 2017-12-01 | 浙江理工大学 | A kind of ultrasonic cell disintegration extraction process of Bai le leaf total polyphenols |
| CN107519151A (en) * | 2017-09-06 | 2017-12-29 | 广西信业生物技术有限公司 | A kind of liquid bandage and preparation method thereof |
| CN108143985A (en) * | 2018-02-28 | 2018-06-12 | 苏州凌科特新材料有限公司 | A kind of medical more skin biology film forming spray and preparation method thereof |
| CN110680879A (en) * | 2019-11-08 | 2020-01-14 | 西安千禾药业股份有限公司 | Traditional Chinese medicine film spraying agent for promoting blood circulation, stopping bleeding, removing necrotic tissue and promoting granulation and preparation method thereof |
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Effective date of registration: 20170727 Address after: 529240 No. 333 Nanshan Road, off street, Jianghai District, Guangdong, Jiangmen, China Applicant after: Jiangmen large Health International Innovation Research Institute Address before: 510062 Yuexiu District East Road, Guangdong, Jiangsu Province, No. 729 compound Applicant before: Guangdong University of Technology |
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Application publication date: 20161116 |