CN106075619B - A kind of coronary vein blood flow flow diverter - Google Patents
A kind of coronary vein blood flow flow diverter Download PDFInfo
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- CN106075619B CN106075619B CN201610744191.1A CN201610744191A CN106075619B CN 106075619 B CN106075619 B CN 106075619B CN 201610744191 A CN201610744191 A CN 201610744191A CN 106075619 B CN106075619 B CN 106075619B
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- 239000008280 blood Substances 0.000 claims abstract description 14
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- 238000003745 diagnosis Methods 0.000 description 1
- PVBALTLWZVEAIO-UHFFFAOYSA-N diodone Chemical compound OC(=O)CN1C=C(I)C(=O)C(I)=C1 PVBALTLWZVEAIO-UHFFFAOYSA-N 0.000 description 1
- 229960001845 diodone Drugs 0.000 description 1
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Classifications
-
- A61M1/0023—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/84—Drainage tubes; Aspiration tips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
- A61M25/04—Holding devices, e.g. on the body in the body, e.g. expansible
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0082—Catheter tip comprising a tool
- A61M2025/0096—Catheter tip comprising a tool being laterally outward extensions or tools, e.g. hooks or fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/12—Blood circulatory system
- A61M2210/125—Heart
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses a kind of coronary vein blood flow flow diverter, including stop member and drainage catheter, the stop member is used to flow into atrium dextrum in orifice of coronary sinus vein blocking blood flow, and the drainage catheter is for draining in vitro venous blood.The present invention is to be constituted and designed according to human coronaries' blood flow rule and human dissection, the blood of the coronary vein reflux containing contrast agent of several cardiac cycles after coronary angiography can be drained in vitro completely, to drain contrast agent in vitro without being stranded in human body, prevent or reduce the generation of radiographic contrast nephropathy.
Description
Technical field
It is especially a kind of for preventing coronarography initiation the present invention relates to a kind of coronary vein blood flow flow diverter
The coronary vein blood flow flow diverter of radiographic contrast nephropathy.
Background technology
In patients with coronary artery disease, there is renal insufficiencies by significant proportion patient.Researches show that Acute Coronary Syndrome Patients
(ACS) about 40% exist in severe renal insufficiency.Coronary angiography is current diagnosis coronary heart disease " goldstandard ", and coronal
It is one of most specific means of most widely used, curative effect in current coronary heart disease treatment that arterial intervention, which is implanted into cardiac stent,.However, by
It needs that contrast agent, a large amount of coronary heart disease is used to be associated with potential renal insufficiency patient and fear radiography in coronary angiography, coronary intervention
The generation of agent nephrosis and cannot row coronary angiography or calcification score, therefore cannot effectively treat or even premature death.
Radiographic contrast nephropathy is using causing acute (in 48 hours) kidney function damage after diodone.Studies have shown that radiography
The harm of agent nephrosis is huge so that the death rate of patient obviously increases.In the retrospective analysis that one is included in 7586 patients, hair
Patient's hospital mortality of raw radiographic contrast nephropathy is 22%, and the mortality that radiographic contrast nephropathy does not occur only has 1.4%.Hair
After raw radiographic contrast nephropathy, the increase of mortality risk can last very long, 1 annual death rate is 12.1% after radiographic contrast nephropathy, 5 years
The death rate 44.6%, the mortality without radiographic contrast nephropathy occurs is respectively 3.7% and 14.5%.Radiographic contrast nephropathy
Most dangerous two factors are chronic renal insufficiency and contrast agent dosage.One is studied Xue Jigan >The patient of 1.8mg/L is random
It is divided into two groups, one group uses contrast agent dosage without limitation, and another group strictly limits, as a result, it has been found that limitation group radiographic contrast nephropathy is fallen ill
Rate is 2%, and unrestricted group of incidence is 26%.It is now recognized that contrast agent Yi Ciyongliang <70ml can effectively reduce contrast agent kidney
The onset risk of disease.Radiographic contrast nephropathy prevents, treats always that medical field is difficult to capture problem for many years, at present still without very
Satisfied prevention or therapy.Aquation is to effectively reduce radiographic contrast nephropathy incidence using what is be widely accepted earliest, at present
Method.But the generation of radiographic contrast nephropathy can not be avoided completely in high-risk patient the method, about 11% chronic kidney is not
Radiographic contrast nephropathy can still occur after fluid infusion for full patient.Although drug therapy, preventative hemodialysis have one to preventing radiographic contrast nephropathy
It is set for using, but effect is not still satisfied, research evidence is still insufficient, fails in wide clinical application.
To sum up content is it is found that research and development effectively prevent the method for radiographic contrast nephropathy caused by coronary angiography or instrument with huge
Social benefit and the market demand.At home and abroad there is no the instruments for preventing radiographic contrast nephropathy caused by coronary angiography at present.It is Chinese public
The patent (CN201610120402.4) opened devises a kind of coronary sinus vein suction catheter, but the conduit is for aspirating
The blood flow of coronary sinus vein inside points is analyzed or is handled, and not for designed for preventing radiographic contrast nephropathy.The patent
Blood flow barrier structure is not designed, the drainage of blood flow in coronary sinus vein is incomplete, still has the blood flow of part can be from coronal quiet
Atrium dextrum is flowed in arteries and veins sinus and is entered in blood circulation.
Invention content
In view of the drawbacks described above of the prior art, the technical problem to be solved by the present invention is to how effectively prevent coronary artery to make
Radiographic contrast nephropathy caused by shadow, calcification score occurs.
Coronary sinus vein refers to a sinus property structure of outer wall after being located at heart, opening rear wall in atrium dextrum.Shown in Fig. 1
For the internal anatomy of coronary vein, coronary vein mainly has coronary sinus vein 1 (being opened on atrium dextrum), anterior cardiac veins and heart Minimum Static
Arteries and veins, wherein coronary sinus vein collect about 90% venous blood for coming from cardiac muscle, and are drained go back to atrium dextrum.Most trouble
Person has half valve mechanism for being referred to as Thebesian valves in orifice of coronary sinus vein, but the not no valve of a part of patient.Note
The mainline for entering coronary sinus vein has atrium sinistrum vein 2, great cardiac vein 3, middle cardiac vein 4, small cardiac vein 5,6 and of rear lateral branch
After prop up 7.The blood flow containing contrast agent can be flowed back into from coronary artery through capillary in coronary vein after coronary angiography, then be converged
Collect coronary sinus vein, atrium dextrum is finally flowed by orifice of coronary sinus vein.
If the blood of the coronary vein reflux of several cardiac cycles after radiography drained in vitro completely, can also incite somebody to action
Contrast agent drains in vitro without being stranded in human body, to prevent or reduce the generation of radiographic contrast nephropathy.
Therefore, to achieve the above object, the present invention provides a kind of drainage method of coronary vein blood flow, the drainage methods
Can be external by being drained in coronary sinus vein by the venous blood flow with contrast agent, prevent it from entering atrium dextrum.It is drained and
Blood flow containing contrast agent can abandon, and be fed back again after can also being filtered contrast agent by specific process in vivo.
Above-mentioned coronary vein blood flow drainage method includes step：
1) blood flow is prevented to flow into atrium dextrum by coronary sinus vein；
2) guide the blood outflow in coronary sinus vein external.
Further, step 1) can be realized by the way that stop member is arranged in orifice of coronary sinus vein.
Further, step 2) can lead to external drainage catheter and realize by being arranged in coronary sinus vein.
The drainage method of coronary vein blood flow according to the present invention, the present invention provides a kind of coronary vein blood flows to draw
Device, including stop member and drainage catheter are flowed, the stop member is used to flow into atrium dextrum in orifice of coronary sinus vein blocking blood flow,
The drainage catheter is for draining in vitro venous blood；The stop member and the drainage catheter can be connected with each other,
It can be separated from each other.
Preferably, the stop member is circular conical surface shape or umbrella shape, and the top of the circular conical surface shape is round and smooth design, is not had
There is wedge angle；When blood flow for stopping coronary sinus vein, the stop member is placed in coronary sinus vein, and top is opposite
Orifice of coronary sinus vein.
Preferably, the stop member is made of skeleton and overlay film, and the material of the skeleton is preferably memorial alloy, most preferably
Material for Nitinol, the overlay film is preferably high molecular film material, most preferably polyurethane film.
In the preferred embodiment of the present invention, the stop member is the circular conical surface shape with round and smooth top, bone
Frame is arranged to several memory alloy wires extended from the vertex of circular conical surface towards the direction for being gradually distance from circular cone axis, described
The outer surface that overlay film is covered in skeleton forms circular conical surface, and on the one hand which has certain elasticity, on the other hand can be convenient for its receipts
Enter in delivery sheath；The skeleton extending direction and the angle of circular cone axial direction are preferably 30-60 degree.
Preferably, the maximum gauge of the stop member is slightly larger than the internal diameter of human coronary vein sinus.
There is the drainage catheter inner cavity, blood can also be placed guiding wire in the inner cavity by being flowed out in inner cavity, are used for
Guide the transport path of the drainage catheter；The drainage catheter is made it be easily bent deformation, is conducive to it using soft material
It is out of shape in the blood vessels；The material of the drainage catheter preferably is selected from polytetrafluoroethylene (PTFE), polyethylene, polypropylene, polyurethane, silica gel
It is one or more of.
Preferably, the drainage catheter is provided with several side openings by the tube wall side of front end, and blood flow can pass through side opening stream
Enter the inner cavity of the drainage catheter and drained in vitro, the quantity of the side opening is preferably 4-20, described to be by front end
In the range of span is from front end 1-55mm.
Preferably, the length of the drainage catheter is 1.0-1.5m, outer diameter 2-5mm, internal diameter 1.5-4.5mm.
Preferably, the aperture of the side opening is 0.5-3mm.
In the preferred embodiment of the present invention, the stop member links together with the drainage catheter, institute
It is circular conical surface shape to state stop member, and the drainage catheter is arranged to pass through from the center of stop member, and the stop member
Opening direction towards the front end of the drainage catheter, it is preferable that the stop member is arranged on apart from the drainage catheter
The position of front end 40-70mm.
Preferably, the L-shaped bending in the front of the drainage catheter can adapt to the out of shape of coronal quiet sinus-great cardiac vein.
The drainage catheter front is placed in working condition in coronary sinus vein and great cardiac vein.It is further preferred that described
(part for entering coronary vein) is gradual from the coarse to fine forward from stop member for drainage catheter, to meet coronary sinus vein to the heart
The variation of big venal distal internal diameter.
Further, the drainage catheter further includes anchoring members, for being anchored the drainage catheter in coronary sinus vein
Or entire flow diverter, it prevents it to be sliding out out of coronary sinus vein and comes.
Preferably, the anchoring members be arranged on the drainage catheter apart from the position of front end 20-40mm.
Preferably, the anchoring members are made of soft memory alloy material, not easy damaged blood vessel, most preferably NiTi
Memorial alloy is made.
In the preferred embodiment of the present invention, the anchoring members are several protrusions, especially aduncate C
Shape protrusion, which is easily contracted in delivery sheath, and the round and smooth not easy damaged blood vessel in surface, the height of the C-shaped projections with
The internal diameter of coronary sinus vein matches so that drainage catheter can be fixed in coronary sinus vein, but not will produce excessive
Tension.Further, filament of the C-shaped protrusion by diameter less than 0.3mm is constituted.The shape of the protrusion not can also be uniquely
Circle, ellipse, arch etc..
Coronary vein blood flow flow diverter provided by the invention can radial dilatation the first form and radial contraction second
It is converted between form；Wherein, first form is that the flow diverter is implanted the work behind the precalculated position of human coronary vein sinus
Make form, second form is the conveying form when flow diverter is conveyed by intravascular.
Further, second form is that the stop member is compressed to the form of fine strip shape or the blocking portion
Part and the anchoring members (if any) are compressed into the form for being close to the drainage catheter, make the coronary vein blood flow flow diverter
It can be loaded into the strip delivery sheath of certain internal diameter.
Preferably, the L-shaped bending in the front of the delivery sheath easily can take in or release the flow diverter.
The production method of the coronary artery flow diverter of the present invention is preferably grinding tool making and laser-engraving technique, can also be adopted
With integrally formed 3D printing technique.
" front end " of the present invention refers to one end far from operator after the drainage catheter is conveyed into human body, this
Invention " rear end " refers to that one end of proximal operator is leaned on after the drainage catheter is conveyed into human body；And it is of the present invention
" preceding " refer to the direction far from operator along conveying axis, " rear " refers to the direction that operator is directed toward along conveying axis.
The present invention is to be constituted and designed according to human coronaries' blood flow rule and human dissection：(1) after coronary angiography
The blood flow containing contrast agent can flow back into coronary vein through capillary from coronary artery and be finally pooled to coronary sinus vein, such as
Fruit drains the blood of the coronary vein reflux of several cardiac cycles after radiography in vitro completely, can also drain contrast agent
Go out in vitro without being stranded in human body, to prevent or reduce the generation of radiographic contrast nephropathy.(2) stop member that the instrument contains compared with
It is thin, and it is located at orifice of coronary sinus vein, the middle cardiac vein near coronary vein mouth will not be blocked in this way；Since stop member is circular cone
Face is designed, and may be stuck at orifice of coronary sinus vein Thebesian valves, to reinforce the fixation of flow diverter.(3) anchoring members are thin
Filiform design, will not be urged to the branch vessel of coronary vein, therefore do not interfere with the reflux of blood.(4) drainage catheter is adopted
It is designed with L-type, it is consistent with coronary vein major blood vessel traveling, be conducive to the fixation of flow diverter.
The present invention has following advantageous effects：
1. operating method is simple：The et al. Ke process of the present invention discharges process, operation behaviour with current conventional plugging device
Make relatively easy；
2. making simple, ripe：The basic material of the present invention can be the same as currently used conduit, stopper materials, making side
Method is prepared relatively easy, ripe with current conduit and plugging device；
3. safe：When the device is implanted into, coronary vein blood flow is drained naturally, and coronary vein pressure will not increase, blood
Liquid is flowing, will not form thrombus, safe；
4. curative effect is affirmed：Research has confirmed at present, and radiographic contrast nephropathy can be greatly reduced by reducing contrast agent dosage,
Although the present invention cannot very by coronary angiography when contrast agent drain it is external (part contrast agent can in coronary angiography by
Coronary ostium is back to aorta and is detained in vivo), but contrast agent can be greatly reduced in human body hold-up, to reduce
Radiographic contrast nephropathy occurs.
The technique effect of the design of the present invention, concrete structure and generation is described further below with reference to attached drawing, with
It is fully understood from the purpose of the present invention, feature and effect.
Description of the drawings
Fig. 1 is coronary vein internal anatomy, wherein：1- coronary sinus veins, the atrium sinistrums 2- vein, 3- great cardiac veins, in the minds of 4-
Branch, 8- left superior pulmonary veins, 9- left lower pulmonary vein, 10- right upper pulmonary vein, 11- after lateral branch, 7- after vein, 5- small cardiac veins, 6-
Right inferior pulmonary vein, 12- inferior caval veins, the atrium sinistrums 13-, the atrium dextrums 14-, 15- left ventricles, 16- right ventricle；
Fig. 2 is the structural schematic diagram of a preferred embodiment of stop member of the present invention；
Fig. 3 is the structural schematic diagram of a preferred embodiment of drainage catheter of the present invention；
Fig. 4 is the structural representation for the preferred embodiment that stop member of the present invention is together with each other with drainage catheter
Figure.
Specific implementation mode
Embodiment 1
Coronary vein blood flow flow diverter of the present invention includes stop member and drainage catheter, wherein the stop member can
Think part pyramid like configuration or umbrella cover structure, for flowing into atrium dextrum in orifice of coronary sinus vein blocking blood flow, part pyramid like configuration
One preferred embodiment is as shown in Fig. 2, the stop member 1 is made of the overlay film 12 of several skeletons 11 and its surface, at it
When the first form of radial dilatation, the skeleton 11 prolongs from the vertex of circular conical surface towards the direction for being gradually distance from circular cone axis
It stretches, is similar to the skeleton of umbrella, the extending direction of the skeleton 11 is 30-60 degree with the angular range of circular cone axial direction.
The skeleton 11 is made of Ultimum Ti material, and the overlay film 12 is made of thin polyurethane film material.The resistance
The maximum gauge of stopper part is slightly larger than the internal diameter of human coronary vein sinus, it can be made preferably to be fixed in coronary sinus vein.
Since different people coronary sinus vein is in different size, the diameter of cone face bottom can design Multiple Type, with full
The requirement of sufficient different crowd.
When the stop member is in the second form of radial contraction, the skeleton 11 is concentrated as the umbrella of gathering
Come, forms fine strip shape, can take in delivery sheath, and its nickel-titanium alloy material has Memorability, when the stop member enters hat
It after predetermined position in shape venous sinus, is released from delivery sheath, which can automatically restore to the of design
One form.
The structure of the blood flow stop member of the present invention is not unique, stops coronal Jing Doukou, anti-hemostasis completely as long as can play
Flow the structure flowed out from coronal Jing Doukou.
Embodiment 2
Fig. 3 show the structural schematic diagram of a preferred embodiment of the drainage catheter of the present invention, which has
Inner cavity 21, blood can place guiding wire by being flowed out in inner cavity in the inner cavity, the transport road for guiding the drainage catheter
Diameter.The length of the drainage catheter is 1.0-1.5m, outer diameter 2-5mm, internal diameter 1.5-4.5mm.
The drainage catheter 2 is provided with several side openings 22 by the tube wall side of front end, and blood flow can flow into institute by side opening 22
It states the inner cavity 21 of drainage catheter and is drained in vitro, the quantity of the side opening 22 is 4-20, aperture 0.5-3mm.
The drainage catheter is made it be easily bent deformation, it is out of shape in the blood vessels to be conducive to it using soft material；It is described to draw
The material of conductance pipe is selected from polytetrafluoroethylene (PTFE), polyethylene, polypropylene, polyurethane, silica gel.
Embodiment 3
Fig. 4 is a kind of preferred embodiment of stop member and drainage catheter combining form of the present invention, is drawn in this embodiment
Conductance pipe 32 passes through the center of stop member 31, and the opening direction of stop member 31 is towards the front end of drainage catheter 32, this
Opening direction can enable the stop member 31 easily be incorporated into and release delivery sheath.Such structure is suitable for described coronal
The case where venous drainage device enters from the right side vein of the coronary sinus vein of Fig. 1.
The combination of aforementioned stop member and drainage catheter is not unique, and the opening direction of stop member is not also unique,
In other embodiments of the present invention, stop member and drainage catheter also can be by being set to the support alloy of drainage catheter front end
Silk is connected with each other, and in such connection type, the drainage catheter is not passed through the center of stop member, and stop member is set
In the front of drainage catheter, opening direction is also opposite.Such structure is suitable for the coronary vein flow diverter from Fig. 1's
The case where left side vein of coronary sinus vein enters.Therefore, it as long as meeting the principle of the present invention, and can achieve the object of the present invention
Any type structure be all feasible.
In the present embodiment, the stop member 31 is circular conical surface shape, is made of skeleton 311 and overlay film 312, distance is drawn
32 front end 40-70mm of conductance pipe.The L-shaped bending in 32 front end of the drainage catheter adapts to walking for great cardiac vein in coronary vein
Shape；And drainage catheter before stop member (enter coronary vein) part, outer diameter is to thin from slightly developing from back to front, with
Meet variation of the coronary sinus vein to great cardiac vein distal inner diameter.
The drainage catheter 32 is provided with several side openings 321 by the tube wall side of front end, and blood flow can be flowed by side opening 321
The inner cavity of the drainage catheter is simultaneously drained in vitro, and the quantity of the side opening 321 is 4-20, aperture 0.5-3mm.
The drainage catheter 32 also has anchoring members 323 at front end, entirely draws for being anchored in coronary sinus vein
Device is flowed, prevents it to be sliding out out of coronary sinus vein and comes, anchoring members 323 are made of soft Ultimum Ti, not rapid wear
Blood trouble pipe, the distance between anchoring members 323 and stop member 31 are 20-50mm.
Anchoring members 323 are several aduncate C-shaped projections as can be seen from Fig. 4, which is easily contracted to conveying sheath
In pipe, and the round and smooth not easy damaged blood vessel in surface, the height of the C-shaped projections and the internal diameter of coronary sinus vein match so that draw
Conductance pipe can be fixed in coronary sinus vein, but not will produce excessive tension.Further, the C-shaped protrusion is by diameter
Filament less than 0.3mm is constituted.The shape of the protrusion not can also be the opposite C-shaped in direction, circle, ellipse, arch uniquely
Shape etc..
The coronary vein blood flow flow diverter can become between the first form of radial dilatation and the second form of radial contraction
It changes；Fig. 4 show structure when it is in the first form, and when it is in the second form, stop member 31 comes closer, tightly
It is labelled to the outside of drainage catheter 32, and anchoring members 323 also shrink the outside for being close to drainage catheter 32, at this point, the coronary vein
Blood flow flow diverter can be loaded into intravascular in delivery sheath and be delivered in coronary sinus vein.
The production method of the present embodiment is grinding tool making and laser-engraving technique.But the preparation method is not unique, other
Preferred embodiment in can also use integrally formed 3D printing technique make.
Embodiment 4
Following steps can be used when the coronary vein blood flow flow diverter implantation of the present invention：
(1) in vitro, using compressing instrument, the coronary vein flow diverter is compeled into fine strip shape and is taken in defeated sheath；
(2) guiding wire is put into coronary sinus vein, along seal wire by the delivery sheath equipped with coronary vein flow diverter
It send to coronary sinus vein；
(3) recession delivery sheath discharges stop member and drainage catheter, the front end of drainage catheter is placed in coronary sinus vein
It is interior；
(4) adjusting position obtains the top alignment orifice of coronary sinus vein of stop member；
(5) it allows the blood flow in coronary sinus vein to be flowed out in vitro along drainage catheter, is drained the blood containing contrast agent
Stream can abandon, and can also be fed back contrast agent filtering in vivo again by specific process；
(6) when that need not drain, conveying epitheca can be pushed forward, packs up stop member, blood flow will be normally from coronal
Venous sinus mouth flows out；
(7) when or else needing using the instrument, will conveying epitheca again toward being pushed forward, entire flow diverter is taken in it is intrathecal, one
It rises and withdraws from vitro.
The preferred embodiment of the present invention has been described in detail above.It should be appreciated that those skilled in the art without
It needs creative work according to the present invention can conceive and makes many modifications and variations.Therefore, all technologies in the art
Personnel are available by logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea
Technical solution, all should be in the protection domain being defined in the patent claims.
Claims (3)
1. a kind of coronary vein blood flow flow diverter, it is characterised in that including stop member and drainage catheter, the stop member is
Circular conical surface shape or umbrella shape, for flowing into atrium dextrum in orifice of coronary sinus vein blocking blood flow；The drainage catheter is used for venous blood
It drains in vitro, the drainage catheter is provided with several side openings by the tube wall side of front end；The drainage catheter includes anchoring
Component prevents it from being slipped out of coronary sinus vein for being anchored the drainage catheter or entire flow diverter in coronary sinus vein
Out, the anchoring members are several aduncate C-shaped projections, and the quantity of the side opening is 4-20, the hole of the side opening
Diameter is 0.5-3mm, and filament of the C-shaped projections by diameter less than 0.3mm is constituted.
2. coronary vein blood flow flow diverter as described in claim 1, it is characterised in that the stop member is by skeleton and overlay film
Composition.
3. coronary vein blood flow flow diverter as claimed in claim 2, it is characterised in that the skeleton is arranged to from circular conical surface
Several memory alloy wires for extending towards the direction for being gradually distance from circular cone axis of vertex, the overlay film is covered in the outer of skeleton
Surface forms circular conical surface.
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| CN201610744191.1A CN106075619B (en) | 2016-08-26 | 2016-08-26 | A kind of coronary vein blood flow flow diverter |
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| CN201610744191.1A CN106075619B (en) | 2016-08-26 | 2016-08-26 | A kind of coronary vein blood flow flow diverter |
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| CN106725636A (en) * | 2017-03-17 | 2017-05-31 | 李响 | A kind of blood inner cell specimen trap inserted in superior vena cava |
| CN108743016B (en) * | 2018-06-29 | 2020-10-20 | 北京诺康达医药科技股份有限公司 | Glaucoma miniature shunt device with variable structure |
| CN112023151B (en) * | 2020-09-28 | 2022-11-22 | 郑州大学第一附属医院 | Postoperative suture-free drainage device |
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| US6551303B1 (en) * | 1999-10-27 | 2003-04-22 | Atritech, Inc. | Barrier device for ostium of left atrial appendage |
| US20080065009A1 (en) * | 2004-08-12 | 2008-03-13 | Neo-Vasc Medical Ltd. | Drug Delivery in the Coronary Sinus |
| US7824357B2 (en) * | 2007-06-11 | 2010-11-02 | Ibrahim Rashid Al-Rashdan | Method and system for preventing contrast associated nephropathy |
| CN201683923U (en) * | 2010-06-09 | 2010-12-29 | 孙浩峰 | Venous tube used in department of cardiac surgery |
| CN102475556A (en) * | 2010-11-22 | 2012-05-30 | 大连创达技术交易市场有限公司 | Vena cava cannula with umbrella-shaped ring |
| CN203354604U (en) * | 2013-07-23 | 2013-12-25 | *** | Thrombus aspiration catheter |
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