CN106075240A - 一种防治猪呼吸道疾病中药微生态制剂及其制备方法 - Google Patents
一种防治猪呼吸道疾病中药微生态制剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种防治猪呼吸道疾病中药微生态制剂及其制备方法,中药原料按重量份配比为:白术50‑70份、黄芪30‑40份、沙姜20‑30份、山楂20‑30份、涩梨20‑30份、蒙莸5‑8份、陈皮10‑15份、石菖蒲10‑15份、白花蛇舌草5‑10份、木通5‑10份。本发明的防治猪呼吸道疾病中药微生态制剂,富含中草药活性物质、活性小肽、乳酸和益生菌,能够提高免疫功能、增强猪抗病力,提高猪生长速度,增加食欲,有效地预防和治疗猪呼吸道疾病,且无毒副作用、无污染、无残留、不产生耐药性,制备方法工艺条件简单。
Description
技术领域
本发明涉及兽药技术领域,尤其涉及一种防治猪呼吸道疾病中药微生态制剂及其制备方法。
背景技术
猪呼吸道疾病综合症(PRDC)以生长速度降低、饲料利用率降低、食欲减退、咳嗽及呼吸困难为特征的疾病,虽然总体死亡率不高,但严重影响猪场的经济效益。而且,呼吸道疾病综合症出现了一些新的特点,一,混合感染的病原体有所变化,病原体为肺炎支原体、繁殖与呼吸综合症病毒(PRRSV)、2型圆环病毒(PCV-2)等的感染为主,再结合其它的细菌继发或混合感染;二,发病时间的改变,断奶后各个阶段的猪均可发病,即从断奶后两周开始,一直到育肥期都可以发生呼吸道疾病综合症。
现有技术,防治猪呼吸道疾病综合症的药剂一般以西药为主,猪场常用的药物组合为枝原净100ppm、金霉素300ppm、阿莫西林400ppm;也可使用枝原净100ppm、氟苯尼考60ppm;或加康500克/吨料,使用时间是在母猪产前、产后各连用1周;仔猪断奶后连用14天;保育舍转群后连用1周。然而,其效果不理想,用药后容易复发。
发明内容
本发明的目的是为了克服现有技术的不足,提供一种防治猪呼吸道疾病中药微生态制剂,富含中草药活性物质、活性小肽、乳酸和益生菌,能够提高免疫功能、增强猪抗病力,提高猪生长速度,增加食欲,有效地防治猪呼吸道疾病,且无毒副作用、无污染、无残留、不产生耐药性,制备方法工艺条件简单。
本发明还提供该防治猪呼吸道疾病中药微生态制剂的制备方法。
为了实现上述目的,本发明采用如下技术方案:
一种防治猪呼吸道疾病中药微生态制剂,中药原料按重量份配比为:白术50-70份、黄芪30-40份、沙姜20-30份、山楂20-30份、涩梨20-30份、蒙莸5-8份、陈皮10-15份、石菖蒲10-15份、白花蛇舌草5-10份、木通5-10份。
优选地,所述的防治猪呼吸道疾病中药微生态制剂,中药原料按重量份配比为:白术60份、黄芪35份、沙姜25份、山楂25份、涩梨25份、蒙莸6份、陈皮12份、石菖蒲12份、白花蛇舌草6份、木通6份。
所述的防治猪呼吸道疾病中药微生态制剂的制备方法,包括以下步骤:
(1)按上述重量份比例称取各中药,将各中药超微粉碎;
(2)加入中药总重量5-7倍量的水,浸泡30-50min,武火煮沸,文火保温30-60min,冷却过滤;滤渣加4-5倍量的水,武火煮沸,文火保温30-60min,冷过滤,合并两次滤液;
(3)收集滤液,向滤液中加入其重量20%的白糖,并煮沸5-10min,冷却至常温,接种滤液重量20%的乳酸杆菌、双岐杆菌及枯草芽孢杆菌制剂,进行发酵,发酵时间为3-5天,发酵温度为30-35℃,得微生态制剂。
本发明在预防猪呼吸道疾病时,将发酵液稀释5-8倍,连续给猪饮用5天;治疗猪呼吸道疾病时,将发酵液稀释3-5倍,连续给猪饮用5天。
本发明中,各中药药理作用如下:
白术,味苦、甘而性温,功能健脾益气,燥湿利水,止汗,安胎。
黄芪,主治小便不通、酒疸黄疾、白浊、萎黄焦渴、老人便秘、血淋、少淋、吐血、咳脓咳血、肺痈、胎动不安、阴汗湿痒。有补中益气敛汗、治慢性肾炎、消蛋白、解毒生肌、补益脾胃等功效;黄芪含皂甙、蔗糖、多糖、多种氨基酸、叶酸及硒、锌、铜等多种微量元素;有增强机体免疫功能、保肝、利尿、抗衰老、抗应激、降压和较广泛的抗菌作用。
沙姜,气香特异,味辛辣,功能主治行气温中,消食,止痛,温中散寒,开胃消食,理气止痛;用于胸膈胀满,脘腹冷痛,饮食不消。
涩梨,味甘,酸,涩,性微温;功能主治消食导滞,理气健脾,主食积停滞,脘腹胀育,泄泻。
蒙莸,甘,温。功能主治:消食理气,祛风湿,活血止痛。主治消化不良,腹胀;外用治风湿性关节炎。
陈皮,理气和中,燥湿化痰,利水通便;主治脾胃不和,脘腹胀痛,不思饮食,呕吐哕逆;痰湿阻肺,咳嗽痰多,胸膈满闷,头目眩晕;用于胸腹胀满等症;既能健脾,又能理气。
石菖蒲,气芳香,味苦、微辛;功能主治:化湿开胃,开窍豁痰,醒神益智。用于脘痞不饥,噤口下痢,神昏癫痫,健忘耳聋;理气,活血,散风,去湿。
白花蛇舌草,性寒,味微酸;归脾、肺经;能清血热、消风散气、解毒退肿、止痛;主治肠热、喉痛、肠痛、大热积热、疮肿;
木通,清心火,利小便,用于胸中烦热,喉痹咽痛。
与已有技术相比,本发明的有益效果如下:
本发明的防治猪呼吸道疾病中药微生态制剂,富含中草药活性物质、活性小肽、乳酸和益生菌,能够提高免疫功能、增强猪抗病力,提高猪生长速度,增加食欲,有效地预防和治疗猪呼吸道疾病,且无毒副作用、无污染、无残留、不产生耐药性,制备方法工艺条件简单。
具体实施方式
以下结合实施例对本发明作进一步的说明,但本发明不仅限于这些实施例,在未脱离本发明宗旨的前提下,所作的任何改进均落在本发明的保护范围之内。
实施例1:
一种防治猪呼吸道疾病中药微生态制剂,中药原料按重量份配比为:白术50份、黄芪40份、沙姜20份、山楂20份、涩梨20份、蒙莸5份、陈皮10份、石菖蒲10份、白花蛇舌草10份、木通5份。
所述的防治猪呼吸道疾病中药微生态制剂的制备方法,包括以下步骤:
(1)按上述重量份比例称取各中药,将各中药超微粉碎;
(2)加入中药总重量5倍量的水,浸泡50min,武火煮沸,文火保温30min,冷却过滤;滤渣加4倍量的水,武火煮沸,文火保温30min,冷过滤,合并两次滤液;
(3)收集滤液,向滤液中加入其重量20%的白糖,并煮沸5min,冷却至常温,接种滤液重量20%的乳酸杆菌、双岐杆菌及枯草芽孢杆菌制剂,进行发酵,发酵时间为3天,发酵温度为30℃,得微生态制剂。
实施例2:
一种防治猪呼吸道疾病中药微生态制剂,中药原料按重量份配比为:白术60份、黄芪35份、沙姜25份、山楂25份、涩梨25份、蒙莸6份、陈皮12份、石菖蒲12份、白花蛇舌草6份、木通6份。
所述的防治猪呼吸道疾病中药微生态制剂的制备方法,包括以下步骤:
(1)按上述重量份比例称取各中药,将各中药超微粉碎;
(2)加入中药总重量6倍量的水,浸泡40min,武火煮沸,文火保温50min,冷却过滤;滤渣加5倍量的水,武火煮沸,文火保温50min,冷过滤,合并两次滤液;
(3)收集滤液,向滤液中加入其重量20%的白糖,并煮沸6min,冷却至常温,接种滤液重量20%的乳酸杆菌、双岐杆菌及枯草芽孢杆菌制剂,进行发酵,发酵时间为4天,发酵温度为32℃,得微生态制剂。
实施例3:
一种防治猪呼吸道疾病中药微生态制剂,中药原料按重量份配比为:白术70份、黄芪40份、沙姜30份、山楂30份、涩梨30份、蒙莸5份、陈皮15份、石菖蒲15份、白花蛇舌草5份、木通10份。
所述的防治猪呼吸道疾病中药微生态制剂的制备方法,包括以下步骤:
(1)按上述重量份比例称取各中药,将各中药超微粉碎;
(2)加入中药总重量7倍量的水,浸泡50min,武火煮沸,文火保温60min,冷却过滤;滤渣加5倍量的水,武火煮沸,文火保温60min,冷过滤,合并两次滤液;
(3)收集滤液,向滤液中加入其重量20%的白糖,并煮沸10min,冷却至常温,接种滤液重量20%的乳酸杆菌、双岐杆菌及枯草芽孢杆菌制剂,进行发酵,发酵时间为5天,发酵温度为35℃,得微生态制剂。
试验例:
(一)预防猪呼吸道疾病实验
(1)随机挑选品种相同、体重相近、饲养与管理条件一致、约80日龄的小猪80头,随机分为4组,分别为A、B、C、D组,每组20头。其中,试验A组采用实施例1的制剂;试验B组采用实施例2的制剂;试验C组采用实施例3的制剂,试验D组不添加任何药物。
(2)试验方法:相同条件下预饲喂一周,早上空腹称重,并做记录。开始试验,连续饲喂5日,每天观察试验猪的临床变化,并进行记录;两个月试验期结束,称重。
(3)疗效判断标准:
轻微为仔猪有明显且连续3次以内打喷嚏或咳嗽。
中度为仔猪有明显且连续3次以上的咳嗽。
严重为仔猪有明显连续咳嗽并气喘,呈腹式呼吸,且消瘦严重。
(4)试验结果:
临床试验结果如下表1:
呼吸道症状 | A组 | B组 | C组 | D组 |
无 | 16 | 19 | 18 | 8 |
轻微 | 2 | 1 | 1 | 1 |
中度 | 2 | 0 | 1 | 6 |
严重 | 0 | 0 | 0 | 4 |
发病率% | 13.33 | 3.33 | 3.33 | 46.67 |
通过上表1的观察,采用本发明的中药微生态制剂对预防猪呼吸道疾病有显著效果。
(二)治疗猪呼吸道疾病实验
(1)试验药品:实施例1、实施例2、实施例3的中药微生态制剂;
(2)试验动物:自然发病,有呼吸道疾病症状的小猪,主要表现为喘气、咳嗽症状。随机挑选品种相同、体重相近、饲养与管理条件一致、出现呼吸道病症状相近的小猪80头,随机分为4组,分别为A、B、C、D组,每组20头。其中,试验A组采用实施例1的制剂,试验B组采用实施例2的制剂,试验C组采用实施例3的制剂,试验D组不添加任何药物。
(3)试验方法:A、B、C组使用时,将中药微生态制剂稀释5倍,连续给猪饮用5天。每天早上8点、晚上8点观察,记录仔猪喘气、咳嗽情况及死亡数。
(4)疗效评价指标:死亡率=死亡猪/试验猪数×100%;治愈率=猪治愈数/试验猪数×100%;有效率=治疗有效猪数/试验猪数×100%。试验结果如下表2:
表2本发明药物对猪呼吸道病疗效统计结果
由上表2可知,试验A、B、C组对猪呼吸道病均有显著疗效;其中试验B组的疗效最好。
Claims (4)
1.一种防治猪呼吸道疾病中药微生态制剂,其特征在于:中药原料按重量份配比为:白术50-70份、黄芪30-40份、沙姜20-30份、山楂20-30份、涩梨20-30份、蒙莸5-8份、陈皮10-15份、石菖蒲10-15份、白花蛇舌草5-10份、木通5-10份。
2.根据权利要求1所述的防治猪呼吸道疾病中药微生态制剂,其特征在于:中药原料按重量份配比为:白术60份、黄芪35份、沙姜25份、山楂25份、涩梨25份、蒙莸6份、陈皮12份、石菖蒲12份、白花蛇舌草6份、木通6份。
3.根据权利要求1所述的防治猪呼吸道疾病中药微生态制剂的制备方法,其特征在于:包括以下步骤:
(1)按上述重量份比例称取各中药,将各中药超微粉碎;
(2)加入中药总重量5-7倍量的水,浸泡30-50min,武火煮沸,文火保温30-60min,冷却过滤;滤渣加4-5倍量的水,武火煮沸,文火保温30-60min,冷过滤,合并两次滤液;
(3)收集滤液,向滤液中加入其重量20%的白糖,并煮沸5-10min,冷却至常温,接种滤液重量20%的乳酸杆菌、双岐杆菌及枯草芽孢杆菌制剂,进行发酵,发酵时间为3-5天,发酵温度为30-35℃,得微生态制剂。
4.根据权利要求1所述的防治猪呼吸道疾病中药微生态制剂,其特征在于:预防猪呼吸道疾病时,将发酵液稀释5-8倍,连续给猪饮用5天;治疗猪呼吸道疾病时,将发酵液稀释3-5倍,连续给猪饮用5天。
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