CN106075120A - A kind of Eczema Creams agent - Google Patents
A kind of Eczema Creams agent Download PDFInfo
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- CN106075120A CN106075120A CN201610526378.4A CN201610526378A CN106075120A CN 106075120 A CN106075120 A CN 106075120A CN 201610526378 A CN201610526378 A CN 201610526378A CN 106075120 A CN106075120 A CN 106075120A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract
The invention discloses the Eczema Creams agent of the dermatosis such as a kind for the treatment of eczema containing beta glucan composition, dermatitis, there is the effects such as sterilization, antiinflammatory, moisturizing and desalination pigment, combine with the composition of raw materials of natural botanical source, for fields such as skin care item, health product and medical products.Described Eczema Creams agent is made up of the raw material of following weight portion: emulsifying agent 2~6 parts, crude vegetal 5~20 parts, beta glucan 25~35 parts, Herba Portulacae extract 2~10 parts, Radix Notoginseng total arasaponins 0.1~2 parts, purified water 20~80 parts.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation treating dermatosis, particularly relate to a kind of treat eczema, dermatitis wet
Rash ointment.
Background technology
Eczema is a kind of common anaphylaxis dermatosis, with rubescent, edema, pruritus and dry for characterize, can with incrustation,
Peel off, bubble, ftracture, hemorrhage or oozing of blood, the course of disease is irregular, in recurrent exerbation, acute pruritus.Recently studying display, eczema can
Infected by multiple-microorganism and cause, staphylococcus aureus, pityrosporum furfur etc. can be detected at eczema skin lesion.Treatment eczema
Primary focus is sterilization, antipruritic, antiinflammatory and moisturizing.Rely primarily on glucocorticoids preparation, tar class clinically at present
Preparation, immunomodulator or antibiotic external preparation treat eczema.But prolonged application hormone and antibiotic, be easily generated clinically
The local untoward reaction such as drug resistance, atrophoderma, telangiectasis, pigmentation.
Chinese medicine composition or the Chinese and western medicinal composition for the treatment of eczema in prior art have disclosed, but prescription is complicated.Such as:
Publication number CN 101391000 A file discloses a kind of topical composition treating eczema and preparation method thereof,
Composite formula in percentage by weight is 1%-10% Pollen Pini extract, 1%-10% Pollen Tyjphae extract and 1%-
10% Spora Lygodii extract, wherein Pollen Pini extract, Pollen Tyjphae extract and Spora Lygodii extract content in the composition is total
With should be at 5%-30%, auxiliary agent includes Pulvis Talci, stearic acid, Borneolum Syntheticum, menthol, glyceryl monostearate, sodium alginate, card ripple
Nurse, triethanolamine, glycerol, vegetable oil, azone etc..
Publication number CN 102861271 A file discloses externally applied anti-inflammation antipruritic ointment preparation and preparation method thereof, according to
Weight ratio a combination thereof thing proportioning is Radix Sophorae Flavescentis 20-50 part, Fructus Cnidii 10-20 part, Fructus Kochiae 20-30 part, Cortex Phellodendri 20-30 part, Rhizoma Atractylodis
20-30 part, Rhizoma Smilacis Glabrae 20-40 part, dried Alumen 10-20 part, Mentholum is appropriate, and ability after needing repeatedly to extract with 70% dehydrated alcohol
Can be made into.
Publication number CN 102861274 A file discloses a kind of external application Chinese medicine treating eczema, according to its group of weight ratio
Compound proportioning is Radix Astragali 20-30 part, Radix Saposhnikoviae 10-20 part, Radix Cynanchi Paniculati 10-20 part, Rhizoma Atractylodis Macrocephalae (parched) 10-20 part, Herba Schizonepetae 10-20 part, hardship
Ginseng 10-20 part, Semen Coicis 15-25 part, Periostracum Cicadae 10-20 part, Radix Glycyrrhizae 6-15 part, Cortex Pseudolaricis 15-25 part, Rhizoma Smilacis Glabrae 10-25 part, cnidium monnieri
Sub-20-30 part, Herba Menthae 10-20 part, Radix Scutellariae 10-20 part, Cortex Dictamni 20-30 part.
Publication number CN 104706824 A file discloses a kind of Chinese medicine preparation treating eczema, according to its group of weight ratio
Compound proportioning is Olibanum 8 parts, Rhizoma Atractylodis 7 parts, the Cortex Eucommiae 8 parts, Cortex Dictamni 5 parts, Radix Polygalae 18 parts, Fructus Cnidii 5 parts, Folium Isatidis 3 parts, gold silver
Spend 8 parts, Semen Plantaginis 0.5 part.
Summary of the invention
The present invention provides a kind of eczema ointment treating the dermatosis such as eczema, dermatitis, with natural materials source for raw material system
Becoming, formula combination is simple, it is possible to sterilization, antipruritic, antiinflammatory and moisturizing, and has antiallergic and repair the effect of impaired skin,
Performance is gentle, non-stimulated to skin, have no side effect, do not produce drug resistance, easy to use and environmental protection, is particularly well-suited to motherhood
Woman, infant and high-risk sensitive group.
For achieving the above object, the technical solution used in the present invention is: a kind of Eczema Creams agent containing beta glucan, including
Following raw material:
Beta glucan 25-35 part, Herba Portulacae extract 2-10 part, Radix Notoginseng total arasaponins 0.1-2 part, crude vegetal 5-20
Part, emulsifying agent 2-6 part, purified water 20-80 part.
Described emulsifying agent is formulated by described weight portion by following three kinds of raw materials: cetearyl alcohol 0.5-3 part, spermaceti
Stearyl glucoside 1-5 part, glyceryl monostearate 1-6 part.
Described crude vegetal by following six kinds of raw materials any two to five kinds formulated with following weight portion:
Shea butter 0.1~8 parts;
Semen Tritici aestivi germ oil 0.1~8 parts;
Oleum Vitis viniferae 0.1~8 parts;
Oleum Caryophylli 0.1~8 parts;
Olive oil 0.1~8 parts;
Perilla oil 0.1~8 parts.
Preferably, described purified water is distilled water or deionized water.
The present invention uses the beneficial effect of aforementioned schemes and the advantage to be:
1. raw material described in, with natural materials for source, gentle can act on skin after certain proportioning non-stimulatedly,
Play sterilization, antipruritic, antiinflammatory and effect of moisturizing.
Wherein:
Beta glucan is with 1, and 3 glycosidic bonds are main chain, and 1,6 glycosidic bond is the naturally occurring polysaccharide of side chain, with patent
Method described in application number 201510725996.7 file obtains, i.e. by Schizophyllum commune Franch. fermented extracted.Skin can be improved thin
The multiplication rate of born of the same parents, promotes collagen protein and the generation of elastin laminin, helps to update and repair impaired skin, promotes healing of cicatrix
Close;Keep moisture of skin, improve the moisturizing degree of skin and the smoothness that compacts;Suppression histamine release of mast cell and de-effectively
Grain effect, sensitive skin of releiving, reduces chafing.
Herba Portulacae extract is the stem from Herba Portulacae and leaf, the bioactive substance obtained with low-temperature extraction method, molten
Solution prepares in the butanediol solution of 39.5%, has broad-spectrum antiseptic and antiinflammatory, anti-allergic effects, and can promote epithelial cell
Physiological function is replied.
Radix Notoginseng total arasaponins is the effective ingredient extracting separation from high-quality Radix Notoginseng, including more than 20 kinds of saponin active substances, 17
Plant trace element, albumen, abundant vitamin, polysaccharide etc., there is removing free radical, antiinflammatory, antioxidation, improve local skin
The blood circulation of skin and metabolism, strengthen the immunity of skin, accelerating wound healing, repair the impaired skin of inflammation.
Shea butter has the effect promoting skin regeneration, preventing photoaging, to the skin suffering from dermatitis, sunburn and scar
Have and significantly promote Healing.The top layer of skin there are the most long-term moistening effect, its spreadability and percutaneous absorbability
Fairly the best, it is particularly well-suited to without greasy formula, stimulation of releiving, moisten epidermal area.
Semen Tritici aestivi germ oil contains abundant vitamin E and vitamin B complex, and vitamin E has holding moisture, skin of moistening
Function, the lipid in protection Skin Cell film and protein so that it is play the effect being combined with moisture, maintain the normal generation of cell
Thank, and the microcirculation of skin can be improved, strengthen the immunity of skin;Vitamin B complex includes vitamin B1, B2, B6 etc., is to constitute
The component of the necessary protease of skin metabolism, simultaneously can activated epithelial, antiinflammatory moisturizing, alleviate pachylosis situation.
Oleum Vitis viniferae can promote the appropriately crosslinked of collagen protein with skin nutrition cell, prevent skin from wrinkle and capsule occur
Bubble, and the coarse and keratinization of skin, and there is the effect removing free radical, accelerate skin metabolism, protect epiderm skin
Cell and regenerative cell;Keep moisture of skin, and oily oiliness skin-friendly is strong, is easily absorbed by the skin, be suitable for various skin and use.
The medical value of Oleum Caryophylli is mainly embodied by eugenol, the polar group on aromatic rings in its chemical constitution, energy
The active group of some enzyme is combined in microorganism, destroys the normal metabolic function of microorganism, reaches to suppress fungus, the work of antibacterial
With.Oleum Caryophylli can promote Drug Percutaneous Absorption.
Vitamin kind and quantity relatively other oils contained by olive oil substantially want many, as wherein vitamin A (and A is former) has
Having and make skin smooth, delicacy and increase the effect of its elasticity, vitamin B1 has the function flattening skin fine corrugations, vitamin
C has enhancing vessel wall elasticity, expands the effects such as blood flow.
Rich in alpha-linolenic acid in perilla oil, alpha-linolenic acid has Platelet Activating Factor and the work of leukotriene generation
With, thus there is effect of anti-allergic inflammation.
Choosing above-mentioned crude vegetal is cream base, it is possible to makes full use of crude vegetal and disappears skin moisture-keeping sterilization
The effects such as scorching, promotion skin injury healing, auxiliary Main Ingredients and Appearance plays drug effect.
2. the raw material that the present invention uses obtains simplicity, and Herba Portulacae extract and Radix Notoginseng total arasaponins are all commercially available,
Beta glucan belongs to a kind of extracellular polysaccharide, originates various, such as Lentinus Edodes, Schizophyllum commune Franch., Ganoderma, yeast etc., to split pleat in the present invention
Bacterium is as the source strain of beta glucan, i.e. by Schizophyllum commune Franch. fermented extracted.Schizophyllum commune Franch. is wide at China's distributional region, strain
Resource is the abundantest.Main Ingredients and Appearance formula of the present invention is simple, takes 3 kinds of raw material prescriptions to be formed.Therefore before there is scale application
Scape.
Detailed description of the invention
Describe embodiments of the present invention in detail below with reference to specific embodiment, whereby how the present invention is applied skill
Art means solve technical problem, and the process that realizes reaching technique effect can fully understand and implement according to this.
If not specializing, the conventional hands that the technological means employed in embodiment is well known to those skilled in the art
Section, the reagent used and product are also available commercial.The source of agents useful for same, trade name and be necessary to list it
Constituent person, all indicates when occurring first.
Embodiment one
A kind of Eczema Creams agent, including following raw material:
Beta glucan 25 parts
Herba Portulacae extract 2 parts
Radix Notoginseng total arasaponins 0.2 part
Semen Tritici aestivi germ oil 3 parts
Oleum Vitis viniferae 3 parts
Cetearyl alcohol 0.5 part
Cetearyl glucoside 1 part
Glyceryl monostearate 1 part
Distilled water 30 parts
Embodiment two
A kind of Eczema Creams agent, including following raw material:
Beta glucan 35 parts
Herba Portulacae extract 8 parts
Radix Notoginseng total arasaponins 1 part
Shea butter 5 parts
Semen Tritici aestivi germ oil 2 parts
Oleum Vitis viniferae 3 parts
8 parts of olive oil
Perilla oil 0.5 part
Cetearyl alcohol 2 parts
Cetearyl glucoside 3 parts
Glyceryl monostearate 1 part
Distilled water 80 parts
Embodiment three
A kind of Eczema Creams agent, including following raw material:
Beta glucan 28 parts
Herba Portulacae extract 3 parts
Radix Notoginseng total arasaponins 0.3 part
Semen Tritici aestivi germ oil 2.5 parts
Oleum Caryophylli 0.5 part
4 parts of olive oil
Cetearyl alcohol 0.6 part
Cetearyl glucoside 1 part
Glyceryl monostearate 1 part
Distilled water 40 parts
Embodiment four
A kind of Eczema Creams agent, including following raw material:
Beta glucan 32 parts
Herba Portulacae extract 6 parts
Radix Notoginseng total arasaponins 0.8 part
Shea butter 4 parts
Semen Tritici aestivi germ oil 4 parts
Perilla oil 3 parts
Cetearyl alcohol 2 parts
Cetearyl glucoside 1 part
Glyceryl monostearate 1 part
Deionized water 60 parts
Embodiment five
A kind of Eczema Creams agent, including following raw material:
Beta glucan 30 parts
Herba Portulacae extract 5 parts
Radix Notoginseng total arasaponins 0.5 part
Shea butter 3 parts
Oleum Vitis viniferae 1 part
3 parts of olive oil
Perilla oil 2 parts
Cetearyl alcohol 0.6 part
Cetearyl glucoside part 1.3 parts
Glyceryl monostearate 1 part
Deionized water 52.5 parts
The present embodiment is optimal case of the present invention.
Drug test
The present invention has carried out animal experiment about inflammatory symptom inhibitory action and skin irritation.Research process is as follows:
Test material: white mice, 18~22g, male and female half and half;Rat, 160~180g, male and female half and half.
Medicine and reagent: eczema ointment, dimethylbenzene, vaseline
Research method 1: the impact of xylol induced mice auricle edema
Take 18~22g Kunming mouse 30, be randomly divided into two groups, often group 15, male and female half and half, respectively matched group,
Eczema ointment group, matched group is coated with excipient (vaseline), and remaining group is coated with relative medicine respectively in mouse right ear, 0.5g/, often
Days 2 times, for three days on end, after the 4th day coating 1 hour each group wash away medicine with distilled water, clean with dry cotton ball.Respectively organize mice
Auris dextra is only coated with dimethylbenzene 0.05ml/, and left ear compares, and puts to death animal after 30 minutes, with 8mm card punch, mice left and right ear is same
Cut Deng position homalographic, with scales/electronic balance weighing, with the difference of left and right auricle weight as swelling, calculate each group of swelling, ask
Go out inhibitory rate of intumesce, result such as following table:
Note: compare with matched group, * p < 0.05
Result shows, eczema ointment can substantially alleviate dimethylbenzene induced mice ear swelling degree, has mice ear inflammation
Obvious inhibiting effect.
Research method 2: the local excitation to rat intact skin is tested
Take rat 10, go to 2 pieces, hair-fields what spinal column both sides, back curved scissors cut 2.5cm x 2.5cm, note not damaging
Hinder skin.Test Shi Meikuai unhairing district is coated with 0.5g eczema ointment and 0.5g substrate (vaseline), respectively with one layer of oilpaper and bilayer
Immobilization with adhesive tape after gauze covering.With scrub water after 24 hours, remove remaining ointment and vaseline, observe and remove after left drug 1
Hour, 24 hours, 48 hours and the skin wound repair (coating position is with or without erythema, edema) of 72 hours, be integrated evaluate
As a result, respectively going hair-fields skin to have no the irritant reaction such as erythema, edema, integrated value is 0.Show eczema ointment to rat intact skin without
Zest.
Claims (6)
1. an Eczema Creams agent, it is characterised in that include following weight parts raw material:
Beta glucan 25-35 part, Herba Portulacae extract 2-10 part, Radix Notoginseng total arasaponins 0.1-2 part, crude vegetal 5-20 part, breast
Agent 2-6 part, purified water 20-80 part.
Eczema Creams agent the most according to claim 1, it is characterised in that described emulsifying agent is pressed described by following three kinds of raw materials
Weight portion is formulated: cetearyl alcohol 0.5-3 part, cetearyl glucoside 1-5 part, glyceryl monostearate 1-6 part.
Eczema Creams agent the most according to claim 1, it is characterised in that described crude vegetal is by following six kinds of raw materials
Any two to five kinds formulated with following weight portion:
Shea butter 0.1~8 parts;
Semen Tritici aestivi germ oil 0.1~8 parts;
Oleum Vitis viniferae 0.1~8 parts;
Oleum Caryophylli 0.1~8 parts;
Olive oil 0.1~8 parts;
Perilla oil 0.1~8 parts.
Eczema Creams agent the most according to claim 1, it is characterised in that: described purified water is distilled water or deionized water.
Eczema Creams agent the most according to claim 1, it is characterised in that: in parts by weight, it preferably includes following raw material:
Beta glucan 28-32 part, Herba Portulacae extract 3-7 part, Radix Notoginseng total arasaponins 0.3-0.8 part, crude vegetal 7-12 part, emulsifying agent
2-4 part, purified water 40-60 part.
Eczema Creams agent the most according to claim 1, it is characterised in that: in parts by weight, optimization formula combination include β-
Glucosan 30 parts, Herba Portulacae extract 5 parts, Radix Notoginseng total arasaponins 0.5 part, shea butter 3 parts, Oleum Vitis viniferae 1 part, 3 parts of olive oil,
Perilla oil 2 parts, cetearyl alcohol 0.6 part, cetearyl glucoside 1.3 parts, glyceryl monostearate 1 part, purified water 52.5
Part.
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Cited By (10)
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CN107096017A (en) * | 2017-06-27 | 2017-08-29 | 成都斌能节能环保科技有限公司 | Treat dermopathic external medicine composition and its application method |
CN109010403A (en) * | 2018-10-24 | 2018-12-18 | 王秀国 | A kind of health care eczema ointment |
CN109125146A (en) * | 2018-11-06 | 2019-01-04 | 南京中医药大学 | The composition and its application in cosmetics of a kind of ganoderma lucidum polysaccharide and caryophyllus oil |
CN110025569A (en) * | 2019-05-16 | 2019-07-19 | 吉林农业科技学院 | A kind of Polysaccharide from Portulaca oleracea emulsifiable paste and preparation method thereof |
CN110769836A (en) * | 2018-05-23 | 2020-02-07 | 浙江立恩生物科技有限公司 | Biological polysaccharide for preventing and treating acne and hormone-dependent dermatitis and application thereof |
CN111713625A (en) * | 2020-06-12 | 2020-09-29 | 江苏微康生物科技有限公司 | Bacillus coagulans solid beverage with efficacy of relieving eczema and preparation method thereof |
CN111973620A (en) * | 2019-05-21 | 2020-11-24 | 浙江立恩生物科技有限公司 | Biological polysaccharide for preventing and treating hormone-dependent dermatitis and application thereof |
US20210393720A1 (en) * | 2020-05-29 | 2021-12-23 | Edmund Waller | Hair Growth Compositions |
CN114432380A (en) * | 2022-02-25 | 2022-05-06 | 李楠 | Traditional Chinese medicine and probiotic composition of cream for treating eczema and preparation process of traditional Chinese medicine and probiotic composition |
CN115737474A (en) * | 2022-08-30 | 2023-03-07 | 江苏长泰药业有限公司 | Preparation method of glucan emulsion, composition containing glucan emulsion and application of composition |
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