CN106074663B - One Plant Extracts and steroid dependent dermatitis repair cream - Google Patents
One Plant Extracts and steroid dependent dermatitis repair cream Download PDFInfo
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Abstract
The present invention relates to daily chemical product technical fields, in particular to a Plant Extracts and steroid dependent dermatitis repair cream.The plant extracts includes close Luo Mu extract, burdock extract, purslane extract and Honegsukle flower P.E.Substitute hormone using plant extracts such as close Luo Mu extract, burdock extract, purslane extract, Honegsukle flower P.Es in the present invention, skin damage can be alleviated, at the same again can nourishes rough skin, antiallergic anti-inflammatory；The dependence got rid of to hormone is not only improved, while natural extract will not carry out additional burden to skin tape；Steroid dependent dermatitis repair cream of the present invention solves the problems, such as that responding time existing for other restorative procedures on the market is slow, dependence is strong, recurrent exerbation and palliative.
Description
Technical field
The present invention relates to daily chemical product technical fields, in particular to a Plant Extracts and steroid dependent dermatitis reparation
Frost.
Background technique
In recent years, consumer causes in effect type cosmetics to pursue quick whitening, reparation and anti-ageing and other effects
The phenomenon that illegal addition hormone, heavy metal, is commonplace.Such as: in whitening and freckle-removing product add quinhydrones, vitamin A acid, fill in rice
The heavy metals such as pine or mercury, lead；Dexamethasone, hydrocortisone etc. are used in antiallergic product；Chlorine is added in product for resolving poxes
Mycin etc.；Even glucocorticoid is largely used in order to reduce allergy rate in some common mask products.In this case, swash
Plain dependence facial dermatitis patient is in geometry times growth trend.Steroid dependent dermatitis is because prolonged and repeated improperly external application hormone causes
Dermatitis.Primary skin lesion disappears after showing as external application glucocorticoid, but inflammatory damage occurs again after deactivating, and needs Reusability sugared
Cortin is to control symptom and a kind of gradually dermatitis for aggravating.The metabolism that can inhibit skin after long-time service hormone, makes
Base cell splitting rate slows down, the lipid of cuticula and protein metabolism are substantially at repressed state, can make angle in this way
Matter confluent monolayer cells are more and more thinner, and skin loses protective layer, can induce a series of skin disease.In recent years, morbidity is in and rises year by year
Trend, stubbornness are refractory more.Therefore, extremely urgent for the demand of the product for the treatment of steroid dependent dermatitis.
The method of main solution steroid dependent dermatitis on the market includes: that 1) hormone Subtraction method, this method are now
Hormone is continued to use, the usage amount of hormone is only slowly reduced, the healing period of this method is too long；2) mineral water cold application,
This method can only respite skin discomfort, cannot fundamentally solve steroid dependent dermatitis, index is not effected a permanent cure；3) change
Cosmetic addition have effects that alleviate or treat steroid dependent dermatitis substance, mainly use " mist cooling ", " anti-inflammatory desensitization ",
The method of " promoting epidermis production ", these methods cause curative effect slow, take effect not since therapy approach is single or not comprehensive enough
It is enough obvious.Accordingly, it is desirable to provide it is a kind of do not add hormone, can effectively treat the skin care item of steroid dependent dermatitis.
Summary of the invention
In view of this, the present invention provides a Plant Extracts and steroid dependent dermatitis repair creams.The plant extract
Object can replace hormone to be added into skin care item；The repair cream can effectively treat steroid dependent dermatitis.
In order to achieve the above-mentioned object of the invention, the present invention the following technical schemes are provided:
The present invention provides a Plant Extracts, including close Luo Mu extract, burdock extract, purslane extract and
Honegsukle flower P.E.
The present invention is extracted using the close Luo Mu extract of plant extracts, burdock extract, purslane extract, honeysuckle
Object.Close Luo Mu extract is unique a kind of xylophyta revivable plant, extraction of leaf and stem in the environment of arid
Object has magical curative effect to inflammation, burn, scald.It can protect the formation of cell protein, active cell itself is anti-oxidant
System, while can detecte the variation of cell water content, enough moisture is supplemented to cell.It is dry that burdock extract treats skin
It is dry, severe pruritus, inflammation, the symptoms such as scar, while the inflammation caused by a variety of causes (outside stimulus or gene) can be inhibited
Inflammation factor significantly improves the immunocompetence and antioxidant activity of skin itself, the effect of releiving and repair skin；Purslane mentions
Object is taken to be also referred to as longevity grass in China, rich in having a large amount of flavonoids, adrenin, polysaccharide and various vitamins, amino acid
Equal compounds, to skin allergy, stimulation, it is anti-inflammatory have a good effect, especially to being used for a long time what steroids cosmetics generated
Skin allergy has apparent anti-allergic effects.Skin sore and furuncle and purulent disease can be medically treated, to eczema, dermatitis rhus, skin
Scorching, pruitus and pain have extraordinary curative effect.Honegsukle flower P.E can wind-dispelling heat-dissipating can also removing summer-heat blood poison, alleviate hormone
Dependence facial dermatitis bring face is scorching hot the symptoms such as to itch.The present invention extracts close Luo Mu extract, burdock extract, purslane
After object, Honegsukle flower P.E are used cooperatively, there is better effect in terms for the treatment of or alleviating steroid dependent dermatitis.
Preferably, in parts by weight, plant extracts includes 0.5~2 part of close Luo Mu extract, burdock extract 0.5
~1.5 parts, 0.5~1.5 part of purslane extract and 0.5~1.5 part of Honegsukle flower P.E.
Preferably, the plant extracts further includes Saussurea involucrata extract and/or marine algae extract.
The present invention also provides the plant extracts in preparation treatment or to alleviate steroid dependent dermatitis drug or skin care item
In application.
The present invention also provides a kind of steroid dependent dermatitis repair creams, including emulsifier, vegetable fat, cuticula reparation
Agent, cell nutrient solution, moisturizer, nano silver, Mi Luomu extract, burdock extract, purslane extract, Honegsukle flower P.E
And solvent.
For the present invention using nano silver as anti-inflammatory desensitizer, plant extracts replaces hormone, while supplementing cell cuticula
Required fatty acid, the nutrient solution of base cell is comprehensive to make the hormonal dependent that a speed that takes effect is fast, curative effect is good
Dermatitis repair cream.
Preferably, emulsifier is hydrolecithin, distearyl acid polyglycerol ester -10, hydroxypropyl double lauramides, spermaceti
One or more of stearyl alcohol, docosyl alcohol；
Preferably, emulsifier is hydrolecithin, distearyl acid polyglycerol ester -10 and docosyl alcohol.Hydrolecithin, two are firmly
The blend system of resin acid polyglycerol ester -10 and docosyl alcohol has the extremely similar structure of same epidermis, has good screen to skin
Effect is covered, and is conducive to the infiltration of effective component, while being also equipped with good moistening effect and product use feeling, is equivalent to crisp
Weak epidermis puts on one layer of soft coat.It can be reduced using this mild emulsifier to skin irritatin and injury.
Preferably, vegetable fat be grape seed oil, jojoba oil, camellia seed oil, Sweet Almond Oil, it is a kind of in olive oil or
It is several；
Preferably, vegetable fat is grape seed oil and jojoba oil.
Preferably, cuticula renovation agent is phytosterin ester, cetostearyl alcohol, ceramide, vitamin E, green tea mention
Take one or more of object, aloe extract, german chamomile flower extract, Fructus Cucumidis sativi extract；
Preferably, cuticula renovation agent is that phytosterin ester, cetostearyl alcohol, ceramide, vitamin E and green tea extract
Object.By ingredients such as addition phytosterols oletate, ceramide and vitamin es, lipid between horn cell can be quickly repaired；It is green
The catechin contained in tea extraction can stimulate the proliferation of ageing skin epidermal keratinocyte, and green tea polyphenols protect Skin Cell
From the injury of ultraviolet light, there is anti-inflammatory effect.
Preferably, cell nutrient solution is acetyl group tetrapeptide -5, soluble protein polysaccharide, beta glucan, Argireline, collagen
One or more of albumen；
Preferably, cell nutrient solution is acetyl group tetrapeptide -5 and soluble protein polysaccharide.Acetyl group tetrapeptide -5 is that skin is dry
The activator of cell can activate stem cell, activation Skin Cell, stimulation fibroblast to produce collagen, inhibit collagen enzyme activity
Property.Enough nutrition needed for soluble protein polysaccharide provides epidermal growth, to accelerate the recovery of entire epidermal tissue.
Preferably, moisturizer is glycerol, methyl propanediol, 1,3 butanediols, propylene glycol, Sodium Hyaluronate, amino acid are protected
One or more of humectant；
Preferably, moisturizer is glycerol, methyl propanediol, Sodium Hyaluronate and amino acid humectant.Sodium Hyaluronate and
Amino acid humectant is natural moisturizing factor, provides the moisture of horn cell abundance, restores skin barrier function from inside to outside.
There can be preferable preservative efficacy as bacteriostatic agent using nano silver in the present invention while any thorn will not be brought
Swash.Nano silver has the bactericidal anti-inflammatory effect of high-efficiency broad spectrum, and permeability is high, antibacterial lasting, the nanometer prepared using nanotechnology
Silver can gradually discharge in system；There are also good biocompatibilities for nano silver simultaneously, can promote wound healing, improve wound
The microcirculation of tissue helps antiallergic anti-inflammatory.
Preferably, solvent is water.
Preferably, steroid dependent dermatitis repair cream includes: hydrolecithin, distearyl acid polyglycerol ester -10, behenyl
It is alcohol, grape seed oil, jojoba oil, phytosterin ester, cetostearyl alcohol, ceramide, vitamin E, green-tea extract, water, sweet
Oil, methyl propanediol, Sodium Hyaluronate, Mi Luomu extract, burdock extract, purslane extract, Honegsukle flower P.E, ammonia
Base acid moisturizer, acetyl group tetrapeptide -5, soluble protein polysaccharide and nano silver.
Preferably, in terms of mass percentage, steroid dependent dermatitis repair cream include: hydrolecithin 1%~
3%, distearyl acid polyglycerol ester -10 0.3%~0.5%, docosyl alcohol 0.5%~1%, grape seed oil 4%~8%, Jojoba
Oil 4%~8%, phytosterin ester 1%~5%, cetostearyl alcohol 0.2%~3%, ceramide 0.02%~0.5%, dimension life
Plain E 0.2%~1%, green-tea extract 0.1%~0.5%, acetyl group tetrapeptide -5 0.8%~2%, soluble protein polysaccharide
1%~2%, glycerol 4%~10%, methyl propanediol 1%~5%, Sodium Hyaluronate 0.1%~1%, amino acid humectant
1%~2%, Mi Luomu extract 0.5%~2%, burdock extract 0.5%~1.5%, purslane extract 0.5%~
1.5%, Honegsukle flower P.E 0.5%~1.5%, nano silver 0.2%~1%, water is supplied.
In embodiment provided by the invention, hydrolecithin 1.5%~2%, distearyl acid polyglycerol ester -100.3%
~0.5%, docosyl alcohol 0.5%~1%, grape seed oil 4%~6%, jojoba oil 4%~5%, phytosterin ester 1%~
1.5%, cetostearyl alcohol 0.8%~1%, ceramide 0.1%~0.2%, vitamin E 0.3%~0.5%, green tea extraction
Object 0.2%~0.3%, acetyl group tetrapeptide -5 0.8%~1.0%, soluble protein polysaccharide 1%~1.2%, glycerol 4%~
5%, methyl propanediol 1%~2%, Sodium Hyaluronate 0.1%~0.3%, amino acid humectant 1%, Mi Luomu extract
0.6%~0.8%, burdock extract 0.8%~1.0%, purslane extract 0.8%~1.0%, Honegsukle flower P.E
0.8%~1.0%, nano silver 0.5%~0.6%, water is supplied.
The present invention also provides the preparation methods of the steroid dependent dermatitis repair cream, comprising: by emulsifier, vegetable oil
Rouge, cuticula renovation agent, cell nutrient solution, moisturizer, nano silver, Mi Luomu extract, burdock extract, purslane are extracted
Object, Honegsukle flower P.E and solvent mix, and obtain steroid dependent dermatitis repair cream.
Preferably, it is Portugal that emulsifier, which is hydrolecithin, distearyl acid polyglycerol ester -10 and docosyl alcohol, vegetable fat,
Grape seed oil and jojoba oil, cuticula renovation agent are that phytosterin ester, cetostearyl alcohol, ceramide, vitamin E and green tea mention
Object is taken, cell nutrient solution is acetyl group tetrapeptide -5 and soluble protein polysaccharide, and moisturizer is glycerol, methyl propanediol, hyalomitome
Sour sodium and amino acid humectant, solvent are water；Preparation method are as follows:
1) hydrolecithin, distearyl acid polyglycerol ester -10, docosyl alcohol, grape seed oil, jojoba oil, phytosterin ester,
Cetostearyl alcohol, ceramide, vitamin E are mixed and heated to 80 DEG C, obtain oily phase；
2) water, glycerol, methyl propanediol, Sodium Hyaluronate are mixed and heated to 85 DEG C, homogeneous is dispersed with stirring uniformly, obtains
To water phase；
3) by oily mutually mixed with water, homogeneous, lasting stirring cooling；
4) close Luo Mu extract, burdock extract, purslane extract, honeysuckle are added after being cooled to 45 DEG C to extract
Object, green-tea extract, amino acid humectant, acetyl group tetrapeptide -5, soluble protein polysaccharide, nano silver stir evenly, filtering.
The present invention provides a Plant Extracts and steroid dependent dermatitis repair creams.The plant extracts includes close sieve
The wooden extract, burdock extract, purslane extract and Honegsukle flower P.E.The present invention at least has one of following advantage:
1, the plants such as close Luo Mu extract, burdock extract, purslane extract, Honegsukle flower P.E are used in the present invention
Extract substitutes hormone, can alleviate skin damage, at the same again can nourishes rough skin, antiallergic anti-inflammatory；It not only improves and gets rid of to sharp
The dependence of element, while natural extract will not carry out additional burden to skin tape；
2, steroid dependent dermatitis repair cream of the present invention uses nano silver as main sterilization, anti-inflammatory desensitizer, not only
Additional burden will not be caused to skin, but also skin can be helped to heal faster, promote skin regeneration；Use nano silver
As main protective system, the shelf-life of long period can be provided；
3, steroid dependent dermatitis repair cream of the present invention has preferable anti-inflammatory, itching-relieving action, can effectively treat hormone
Dependence facial dermatitis, and stability is good, solves that responding time existing for other restorative procedures on the market is slow, dependence is strong, anti-
Recurrence makees and palliative problem；
4, steroid dependent dermatitis repair cream of the present invention uses oil-in-water system, can help while providing salubrious skin sense
It helps skin to form one layer of oil film, external injury is isolated；
5, the emulsifier and grease that the present invention uses are all from plant extracts, and additional burden will not be caused to skin；
6, the form that steroid dependent dermatitis repair cream of the present invention is prepared into cream makes patient easy to use, and without it
His peculiar smell；
7, the preparation method simple process of steroid dependent dermatitis repair cream of the present invention, it is pollution-free, it is suitable for extensive life
It produces.
Specific embodiment
The invention discloses a Plant Extracts and steroid dependent dermatitis repair cream, those skilled in the art can be borrowed
Reflect present disclosure, is suitably modified realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications are to this field
It is it will be apparent that they are considered as being included in the present invention for technical staff.Method and application of the invention has passed through
Preferred embodiment is described, related personnel obviously can not depart from the content of present invention, in spirit and scope to described herein
Methods and applications be modified or appropriate changes and combinations, carry out implementation and application the technology of the present invention.
The raw materials used or city auxiliary material Jun Keyou in plant extracts and steroid dependent dermatitis repair cream provided by the invention
Field is bought.
Close Luo Mu extract comes from the same limited public affairs of chemistry in Guangzhou from Guangzhou Ao Xue Chemical Co., Ltd., burdock extract
Department, purslane extract are from hundred Hao Bo Co., Ltd of Guangzhou, Honegsukle flower P.E from the bright limited public affairs of biotechnology of Guangzhou remittance
Department.
Below with reference to embodiment, the present invention is further explained:
Embodiment 1
The present invention is using close Luo Mu extract, burdock extract, purslane extract, Honegsukle flower P.E this 4 kinds plant
Object extract replaces hormone, and the composition of specific plant extracts is as follows:
0.6 part of 1: Mi Luomu extract of plant extracts, 0.8 part of burdock extract, 1 part of purslane extract, honeysuckle
0.8 part of extract；
0.5 part of 2: Mi Luomu extract of plant extracts, 1.5 parts of burdock extract, 0.5 part of purslane extract, gold and silver
1.5 parts of flower extract；
2 parts of 3: Mi Luomu extract of plant extracts, 0.5 part of burdock extract, 1.5 parts of purslane extract, honeysuckle
0.5 part of extract.
Pharmacodynamic test is carried out using above-mentioned plant extracts and each taste Chinese medical extract, specific test method is as follows:
Example steroid dependent dermatitis patient is randomly divided into 8 groups and is randomly divided into 8 groups, wherein 1-7 group is treatment group, is made respectively
With plant extracts 1, plant extracts 2, plant extracts 3, Mi Luomu extract, burdock extract, purslane extract, gold
Honeysuckle flower extract, is applied to face, pats to absorption, frequency of use is 2 times/d, each 2g；8th group be control group, using gram
Department's ointment is not applied to face, and frequency of use is 2 times/d.Wherein, 8 groups of the course for the treatment of is 90d.After 90d, drug withdrawal 2d is seen
Examine curative effect.
Test result is as follows:
Therapeutic evaluation: respectively testing the skin of face of volunteer, and test content includes red and swollen, antipruritic, capillary
Expansion, dry skin furfur.Following four can be divided into according to result:
Recovery from illness: red and swollen, capillarectasia mitigates 90% or more, and gargalesthesia completely disappears, and dry skin furfur disappears；
Effective: red and swollen, capillarectasia mitigates 70% or more, and gargalesthesia disappears substantially, and dry skin furfur disappears substantially；
Effective: red and swollen, capillarectasia mitigates 50% or more, and gargalesthesia mitigates, and dry skin furfur mitigates；
Invalid: red and swollen, capillarectasia mitigation is unobvious, and gargalesthesia mitigation is unobvious, and dry skin furfur mitigates unobvious.
12 groups of patient clinical effects of table compare (%)
The result shows that: treatment group has the effect of steroid dependent dermatitis certain.Wherein treatment group 1-3 is compared with treatment group 4-
7 have more preferably therapeutic effect.
Embodiment 2
The repair cream of steroid dependent dermatitis containing nano silver includes following components in the present embodiment:
Hydrolecithin 1.5%, distearyl acid polyglycerol ester -10 0.5%, docosyl alcohol 0.5%, grape seed oil 4%, suddenly
Bar oil 4% suddenly, phytosterin ester 1.5%, cetostearyl alcohol 0.8%, ceramide 0.1%, vitamin E 0.3%, deionized water
74.3%, glycerol 4%, methyl propanediol 1.5%, Sodium Hyaluronate 0.1%, Mi Luomu extract 0.6%, burdock extract
0.8%, purslane extract 1%, Honegsukle flower P.E 0.8%, green-tea extract 0.2%, amino acid humectant 1%, acetyl
Base tetrapeptide -51%, soluble protein polysaccharide 1%, nano silver 0.5%.
Preparation method is: 1) hydrolecithin, distearyl acid polyglycerol ester -10, docosyl alcohol, grape seed oil, Jojoba
Oil, phytosterin ester, cetostearyl alcohol, ceramide, vitamin E are added in oily phase pot that be heated to 80 DEG C of heat preservations spare；2) will
Deionized water, glycerol, methyl propanediol, Sodium Hyaluronate, which are added in emulsion pot, is heated to 85 DEG C, homogeneous 5min, stirs 30min
It is uniformly dispersed, 3) Material in oily phase pot is slowly pumped into emulsion pot, homogeneous 5min, lasting stirring cooling；4) it is cooled to
Close Luo Mu extract, burdock extract, purslane extract, Honegsukle flower P.E, green-tea extract, ammonia are separately added into after 45 DEG C
Base acid moisturizer, acetyl group tetrapeptide -5, soluble protein polysaccharide, nano silver stir evenly；4) 200 mesh filtering and discharging.
Embodiment 3
The repair cream of steroid dependent dermatitis containing nano silver includes following components in the present embodiment:
Hydrolecithin 1.8%, distearyl acid polyglycerol ester -10 0.3%, docosyl alcohol 0.6%, grape seed oil 4.5%,
Jojoba oil 5%, phytosterin ester 1%, cetostearyl alcohol 0.8%, ceramide 0.15%, vitamin E 0.5%, deionization
Water 71.85%, glycerol 5%, methyl propanediol 1%, Sodium Hyaluronate 0.2%, Mi Luomu extract 0.8%, burdock extract
0.8%, purslane extract 0.8%, Honegsukle flower P.E 1%, green-tea extract 0.3%, amino acid humectant 1%, acetyl
Base tetrapeptide -50.8%, soluble protein polysaccharide 1.2%, nano silver 0.6%.
Preparation method is: 1) hydrolecithin, distearyl acid polyglycerol ester -10, docosyl alcohol, grape seed oil, Jojoba
Oil, phytosterin ester, cetostearyl alcohol, ceramide, vitamin E are added in oily phase pot that be heated to 80 DEG C of heat preservations spare；2) will
Deionized water, glycerol, methyl propanediol, Sodium Hyaluronate, which are added in emulsion pot, is heated to 85 DEG C, homogeneous 5min, stirs 30min
It is uniformly dispersed, 3) Material in oily phase pot is slowly pumped into emulsion pot, homogeneous 5min, lasting stirring cooling；4) it is cooled to
Close Luo Mu extract, burdock extract, purslane extract, Honegsukle flower P.E, green-tea extract, ammonia are separately added into after 45 DEG C
Base acid moisturizer, acetyl group tetrapeptide -5, soluble protein polysaccharide, nano silver stir evenly；4) 200 mesh filtering and discharging.
Embodiment 4
The repair cream of steroid dependent dermatitis containing nano silver includes following components in the present embodiment:
Hydrolecithin 2%, distearyl acid polyglycerol ester -10 0.3%, docosyl alcohol 1%, grape seed oil 6%, Jojoba
Oil 5%, phytosterin ester 1%, cetostearyl alcohol 1%, ceramide 0.2%, vitamin E 0.5%, deionized water 68.2%,
Glycerol 5%, methyl propanediol 2%, Sodium Hyaluronate 0.3%, Mi Luomu extract 0.8%, burdock extract 1%, purslane
Extract 1%, Honegsukle flower P.E 0.8%, green-tea extract 0.3%, amino acid humectant 1%, acetyl group tetrapeptide-
50.8%, soluble protein polysaccharide 1.2%, nano silver 0.6%.
Preparation method is: 1) hydrolecithin, distearyl acid polyglycerol ester -10, docosyl alcohol, grape seed oil, Jojoba
Oil, phytosterin ester, cetostearyl alcohol, ceramide, vitamin E are added in oily phase pot that be heated to 80 DEG C of heat preservations spare；2) will
Deionized water, glycerol, methyl propanediol, Sodium Hyaluronate, which are added in emulsion pot, is heated to 85 DEG C, homogeneous 5min, stirs 30min
It is uniformly dispersed, 3) Material in oily phase pot is slowly pumped into emulsion pot, homogeneous 5min, lasting stirring cooling；4) it is cooled to
Close Luo Mu extract, burdock extract, purslane extract, Honegsukle flower P.E, green-tea extract, ammonia are separately added into after 45 DEG C
Base acid moisturizer, acetyl group tetrapeptide -5, soluble protein polysaccharide, nano silver stir evenly；4) 200 mesh filtering and discharging.
Embodiment 5
Test 1: stability analysis is carried out to embodiment 2-4 repair cream
Specific method executes standard with reference to moisturizing cream QB/T 1857-2013:
1, resistance to Thermal test: Example 2-4 dependence facial dermatitis repair cream is placed under 48 DEG C of environment, is observed after standing 90 days；
2, resist cold and test: Example 2-4 dependence facial dermatitis repair cream is placed under -10 DEG C of environment, is observed after standing 90 days；
3, loop test: the dependence facial dermatitis repair cream that Example 2-4 is produced is placed under 48 DEG C of environment, stands 12h；Again
The dependence facial dermatitis repair cream that embodiment 2-4 is produced is placed under -10 DEG C of environment；Continuously repeat this circulation three times.
Test result is as follows:
The stability of the dependence facial dermatitis repair cream of the present invention of table 2
| Test group | It is heat-resisting | It is cold-resistant | Circulation |
| Embodiment 2 | Without layering | Without layering | Without layering |
| Embodiment 3 | Without layering | Without layering | Without layering |
| Embodiment 4 | Without layering | Without layering | Without layering |
Test 2: antiphlogistic effects analysis is carried out to embodiment 2-4
Using paraxylene induced mice auricular concha oedema as inflammatory model.Mouse is divided into 5 groups, 2 groups of embodiment, embodiment 3
Group, 4 groups of embodiment, blank control group (physiological saline) and Butyl flufenamate positive controls, then with 10g/KG's
Dosage applies 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, blank control group (physiological saline) and Butyl flufenamate
It smears after the ear of mouse.Observation repair cream causes the inhibiting effect of swelling to inflammation.
According to the experimental results, it being compareed with blank assay group, embodiment 2-4 group has preferable inhibitory effect to inflammation,
Through measurement and data analyze to obtain embodiment 2-4 and positive controls be respectively 39.25% to the inhibiting rate of mouse ear swelling,
42.35%, 46.87% and 27.56%.
Test 3: antipruritic effect analysis is carried out to embodiment 2-4
32 mouse are randomly divided into 4 groups, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, blank control group.According to
Repair cream is applied to the right metapedes of mouse by the applying amount of 10g/KG, and control group smears the distilled water of equivalent.After being spaced 10min, open
Begin surface of a wound Chu Di 0.01% histamine phosphate 0.05ml/ only, hereafter at interval of 3min successively with 0.01%, 0.02%,
0.03%, 0.04% increasing concen-trations are 0.05%ml/ every time, until mouse occur later adds right metapedes, to there is mouse
When later licking foot to histamine total amount be antipruritic threshold.Test result is as follows:
3 antipruritic effect test result of table
| Group | Number of animals | Itch-threshold (μ g) |
| Control group | 8 | 36.1 |
| Embodiment 2 | 8 | 356.5 |
| Embodiment 3 | 8 | 389.3 |
| Embodiment 4 | 8 | 400.2 |
By above-mentioned test result it is found that relative to control group, 2~4 repair cream of the embodiment of the present invention has preferable antipruritic
Inhibitory effect.
Test 4: clinical effectiveness test
80 ages meet tested standard volunteer between 30-35 years old, are randomly assigned to be 4 groups, respectively embodiment 2
Group, 3 groups of embodiment, 4 groups of embodiment and control group.It is applied to face using repair cream 0.3-0.5g sooner or later daily, control group uses
Same dosage Butyl flufenamate is 90 days using the time.
Therapeutic evaluation: respectively testing the skin of face of volunteer, and test content includes red and swollen, antipruritic, capillary
Expansion, dry skin furfur.Following four can be divided into according to result:
Recovery from illness: red and swollen, capillarectasia mitigates 90% or more, and gargalesthesia completely disappears, and dry skin furfur disappears；
Effective: red and swollen, capillarectasia mitigates 70% or more, and gargalesthesia disappears substantially, skin
Dry furfur disappears substantially；
Effective: red and swollen, capillarectasia mitigates 50% or more, and gargalesthesia mitigates, and dry skin furfur mitigates；
Invalid: red and swollen, capillarectasia mitigation is unobvious, and gargalesthesia mitigation is unobvious, and dry skin furfur mitigates unobvious.
Test result is as follows:
The test of 4 clinical effectiveness of table
The result shows that: embodiment 2-4 has a better effect steroid dependent dermatitis tool, with Butyl flufenamate
Curative effect difference is unobvious.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (9)
1. a Plant Extracts, which is characterized in that including close Luo Mu extract, burdock extract, purslane extract and gold
Honeysuckle flower extract；
In parts by weight, the plant extracts includes 0.5~2 part of close Luo Mu extract, 0.5~1.5 part of burdock extract, horse
0.5~1.5 part and 0.5~1.5 part of Honegsukle flower P.E of sativa extract.
2. plant extracts according to claim 1, which is characterized in that the plant extracts further includes Saussurea involucrata extract
And/or marine algae extract.
3. plant extracts as claimed in claim 1 or 2 is in preparation treatment or alleviates steroid dependent dermatitis drug or skin care item
In application.
4. a kind of steroid dependent dermatitis repair cream, which is characterized in that including emulsifier, vegetable fat, cuticula renovation agent, thin
Born of the same parents' nutrient solution, moisturizer, nano silver, solvent and plant extracts as claimed in claim 1 or 2.
5. steroid dependent dermatitis repair cream according to claim 4, which is characterized in that the emulsifier is hydrogenation lecithin
One or more of rouge, distearyl acid polyglycerol ester -10, hydroxypropyl double lauramide, cetostearyl alcohol, docosyl alcohols；
The vegetable fat is grape seed oil, jojoba oil, camellia seed oil, Sweet Almond Oil, one or more of in olive oil；
The cuticula renovation agent is phytosterin ester, cetostearyl alcohol, ceramide, vitamin E, green-tea extract, aloe
One or more of extract, german chamomile flower extract, Fructus Cucumidis sativi extract；
The cell nutrient solution is acetyl group tetrapeptide -5, in soluble protein polysaccharide, beta glucan, Argireline, collagen
It is one or more of；
The moisturizer is glycerol, in methyl propanediol, 1,3 butanediols, propylene glycol, Sodium Hyaluronate, amino acid humectant
It is one or more of；
The solvent is water.
6. steroid dependent dermatitis repair cream according to claim 4 or 5, which is characterized in that the hormonal dependent skin
Scorching repair cream includes: hydrolecithin, distearyl acid polyglycerol ester -10, docosyl alcohol, grape seed oil, jojoba oil, phytosterol
Ester, cetostearyl alcohol, ceramide, vitamin E, green-tea extract, water, glycerol, methyl propanediol, Sodium Hyaluronate, close sieve
It is the wooden extract, burdock extract, purslane extract, Honegsukle flower P.E, amino acid humectant, acetyl group tetrapeptide -5, solvable
Property proteoglycan and nano silver.
7. steroid dependent dermatitis repair cream according to claim 6, which is characterized in that in terms of mass percentage, institute
State steroid dependent dermatitis repair cream include: hydrolecithin 1%~3%, distearyl acid polyglycerol ester -10 0.3%~
0.5%, docosyl alcohol 0.5%~1%, grape seed oil 4%~8%, jojoba oil 4%~8%, phytosterin ester 1%~5%,
Cetostearyl alcohol 0.2%~3%, ceramide 0.02%~0.5%, vitamin E 0.2%~1%, green-tea extract 0.1%
~0.5%, acetyl group tetrapeptide -5 0.8%~2%, soluble protein polysaccharide 1%~2%, glycerol 4%~10%, methyl-prop two
Alcohol 1%~5%, Sodium Hyaluronate 0.1%~1%, amino acid humectant 1%~2%, Mi Luomu extract 0.5%~2%,
Burdock extract 0.5%~1.5%, purslane extract 0.5%~1.5%, Honegsukle flower P.E 0.5%~1.5%, nanometer
Silver 0.2%~1%, water is supplied.
8. the preparation method of steroid dependent dermatitis repair cream as claimed in claim 4, which is characterized in that by emulsifier, plant
Grease, cuticula renovation agent, cell nutrient solution, moisturizer, nano silver, Mi Luomu extract, burdock extract, purslane are extracted
Object, Honegsukle flower P.E and solvent mix, and obtain steroid dependent dermatitis repair cream.
9. preparation method as claimed in claim 8, which is characterized in that the emulsifier is hydrolecithin, distearyl acid is poly-
Glyceride -10 and docosyl alcohol, the vegetable fat are grape seed oil and jojoba oil, and the cuticula renovation agent is phytosterol
Ester, cetostearyl alcohol, ceramide, vitamin E and green-tea extract, the cell nutrient solution are acetyl group tetrapeptide -5 and solvable
Property proteoglycan, the moisturizer be glycerol, methyl propanediol, Sodium Hyaluronate and amino acid humectant, the solvent be water；
Preparation method specifically:
1) hydrolecithin, distearyl acid polyglycerol ester -10, docosyl alcohol, grape seed oil, jojoba oil, phytosterin ester, spermaceti
Stearyl alcohol, ceramide, vitamin E are mixed and heated to 80 DEG C, obtain oily phase；
2) water, glycerol, methyl propanediol, Sodium Hyaluronate are mixed and heated to 85 DEG C, homogeneous is dispersed with stirring uniformly, obtains water
Phase；
3) by oily mutually mixed with water, homogeneous, lasting stirring cooling；
4) close Luo Mu extract, burdock extract, purslane extract, Honegsukle flower P.E, green is added after being cooled to 45 DEG C
Tea extraction, amino acid humectant, acetyl group tetrapeptide -5, soluble protein polysaccharide, nano silver stir evenly, filtering.
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| CN107184410A (en) * | 2017-04-28 | 2017-09-22 | 广州瑞誉化工科技有限公司 | A kind of skin cream with steroid dependent dermatitis repair function |
| CN107260595A (en) * | 2017-06-01 | 2017-10-20 | 南京辅安堂药业有限公司 | One Plant Extracts antiallergy cream and preparation method thereof |
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| FR3080032B1 (en) | 2018-04-13 | 2020-04-17 | Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic | USE OF A NEW COMPOSITION TO PREVENT OR SLOW DOWN THE APPEARANCE OF SIGNS OF INFLAMMATION |
| FR3080030B1 (en) | 2018-04-13 | 2020-04-24 | Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic | USE OF A NEW COMPOSITION TO PREVENT OR SLOW DOWN THE APPEARANCE OF THE AESTHETIC SIGNS RELATED TO THE PRESENCE OF EXCESS SEBUM |
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| CN109394565B (en) * | 2018-12-10 | 2021-08-03 | 广州睿森生物科技有限公司 | Moisturizing and repairing composition and application thereof |
| CN110464697A (en) * | 2019-09-19 | 2019-11-19 | 珠海市新高生物科技研究院有限公司 | A method of for skin Eradicates acne and reparation |
| CN111067831A (en) * | 2020-01-06 | 2020-04-28 | 深圳市夕晨生物科技有限公司 | Repair milk and preparation method thereof |
| WO2023249915A1 (en) * | 2022-06-21 | 2023-12-28 | L'oreal | Cosmetic composition comprising natural emulsifiers and thiopyridinone compounds |
| FR3141624A1 (en) * | 2022-11-04 | 2024-05-10 | L'oreal | COMPOSITION COMPRISING A THIOPYRIDINONE-TYPE COMPOUND AND POLYGLYCERYL-BASED EMULSIFIERS |
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