CN106074504A - The application in preparation treatment hypertrophy of the prostate medicine of indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof - Google Patents
The application in preparation treatment hypertrophy of the prostate medicine of indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof Download PDFInfo
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- CN106074504A CN106074504A CN201610433542.7A CN201610433542A CN106074504A CN 106074504 A CN106074504 A CN 106074504A CN 201610433542 A CN201610433542 A CN 201610433542A CN 106074504 A CN106074504 A CN 106074504A
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- indole
- derivative
- carbinol
- capsule
- methyl hydride
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to biomedicine field, specially indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof the application in preparation treatment hypertrophy of the prostate medicine, and the capsule product of a kind of indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof.Inventive formulation is simpler, and more scientific and reasonable, by adding indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof so that the state of an illness of prostate patient is suppressed relatively, mitigates the misery of prostate patient；By ten taste Chinese herbal medicines such as plantain seed, golden cypress, the dried rhizome of rehmannia, the radix paeoniae rubrathe, the red sage root, the bighead atractylodes rhizome, lotus nut, Poria cocos, selfheal, black nightshades as auxiliary material, reach the effect assisting indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof to treat prostate enlargement, thus fundamentally treat prostate enlargement, long-term taking, makes Rehabilitation.
Description
Technical field
The present invention relates to biomedicine technical field, specially indole-3-carbinol, di-indole methyl hydride and derivative thereof are in system
Application in standby treatment hypertrophy of the prostate medicine.
Background technology
Prostate enlargement onset is slow, and middle-aged male need to watch out for prostate enlargement, and the symptom of prostate enlargement includes: uroflow
Still leave in unable, sensation bladder urine do not drain, have any problem when starting to urinate, pollakiuria, urgent urination etc., when the feelings of prostatitis adenoncus
Condition is gradually serious, and urethra will be subject to bigger pressure to cause intravesical urine not discharge.In the minority male sex, prostate
The obstruction that enlargement is caused can cause repeated infection, causes dysuria and long calculus.Treatment prostatitis of the prior art adenoncus
Big medicine mostly is Western medicine, owing to Western medicine side effect is many, and can not tackle the problem at its root, therefore, it is proposed that Chinese and Western knot
The medicine of the treatment prostate enlargement closed.
Content of the invention
It is an object of the invention to provide indole-3-carbinol, di-indole methyl hydride and derivative thereof at preparation treatment prostate
Application in loose medicine, with the problem solving to propose in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme: indole-3-carbinol, di-indole methyl hydride and derivative
Application in preparation treatment hypertrophy of the prostate medicine for the thing.
Preferably, this capsule product includes following composition by weight: indole-3-carbinol 9-14 part, di-indole methyl hydride 3-7 part,
Indole-3-carbinol derivative 4-9 part, diindolylmethane derivative 6-13 part, Capsules preparation 23-40 part, auxiliary material 30-90
Part.
Preferably, described Capsules preparation includes following composition by weight: Arabic gum 5-9 part, gelatin 7-12 part, hydroxypropyl
Ylmethyl cellulose 11-15 part.
Preferably, described auxiliary material includes following composition by weight: plantain seed 3-7 part, golden cypress 2-5 part, dried rhizome of rehmannia 4-8 part, the radix paeoniae rubrathe
3-6 part, red sage root 4-9 part, bighead atractylodes rhizome 7-11 part, lotus nut 3-8 part, Poria cocos 5-9 part, selfheal 7-12 part, black nightshade 10-14 part.
Preferably, this capsule product is prepared by following steps:
Required raw material is weighed according to certain component ratio and takes by S1: weigh proportioning；
S2: capsule shell raw material makes, and all puts into Arabic gum, gelatin and hydroxypropyl methyl cellulose in same equipment and carries out
Dissolution process, is loaded with water in this equipment, heats water to 70-109 degree Celsius, and to the Arabic gum in this equipment, gelatin
Being stirred with hydroxypropyl methyl cellulose, the speed wherein stirring is 1000-1700r/min；
The shaping of S3: capsule shell makes, and all measures the Arabic gum being stirred, gelatin and Gonak and pours into
Carrying out being cooled to capsule shell in mold for empty capsule standby, the temperature of cooling shaping is 10-51 degree Celsius；
S4: auxiliary material solution makes, by plantain seed, golden cypress, the dried rhizome of rehmannia, the radix paeoniae rubrathe, the red sage root, white, lotus nut-, Poria cocos, selfheal, black nightshade
Putting in firing equipment together with water and heating, the time of heating is 24-48 hour, and the temperature of heating is that 88-114 is Celsius
Degree, and auxiliary material solution is stirred, the speed of stirring is 800-1200r/min；
S5: filtering auxiliary material, the auxiliary material after terminating heating transfers to filter in filter plant, by former for solid adjuvant material therein
Material removes, and preserves solution and uses；
S6: drug powder makes, and spreads out indole-3-carbinol, di-indole methyl hydride, indole-3-carbinol derivative and di-indole methyl hydride
Biology all puts in auxiliary material solution and stirs, and a length of 30-70 minute during stirring, whipping temp is 80-114 degree Celsius, obtains medicine
Drug solution is transferred in evaporation equipment be evaporated crystallization, obtains medical solid, be ground medical solid by solution,
Obtain drug powder；
S7: capsule makes, and is uniformly positioned in the inner chamber of each capsule shell drug powder according to certain weight, capsule system
Complete.
Compared with prior art, the invention has the beneficial effects as follows: inventive formulation is simpler, and more science is closed
Reason, by adding indole-3-carbinol, di-indole methyl hydride and derivative thereof so that the state of an illness of prostate patient is suppressed relatively,
Mitigate the misery of prostate patient；By plantain seed, golden cypress, the dried rhizome of rehmannia, the radix paeoniae rubrathe, the red sage root, white, lotus nut-, Poria cocos, selfheal, dragon
Certain herbaceous plants with big flowers etc. ten taste Chinese herbal medicine, as auxiliary material, reaches auxiliary indole-3-carbinol, di-indole methyl hydride and derivative thereof and enters prostate enlargement
The effect of row treatment, thus fundamentally treat prostate enlargement, long-term taking, make Rehabilitation.
Detailed description of the invention
Technical scheme in the embodiment of the present invention will be clearly and completely described below, it is clear that described enforcement
Example is only a part of embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, this area is common
The every other embodiment that technical staff is obtained under the premise of not making creative work, broadly falls into the model of present invention protection
Enclose.
The present invention provides indole-3-carbinol, di-indole methyl hydride and derivative thereof in preparation treatment hypertrophy of the prostate medicine
Application technology scheme:
Embodiment one
The present invention provides a kind of technical scheme: indole-3-carbinol, di-indole methyl hydride and derivative thereof are fertile at preparation treatment prostate
Application in big medicine.
This capsule product includes following composition by weight: indole-3-carbinol 11 parts, di-indole methyl hydride 6 parts, indole-3-carbinol
7 parts of derivative, diindolylmethane derivative 11 parts, 29 parts of Capsules preparation, auxiliary material 65 parts.
Capsules preparation includes following composition by weight: Arabic gum 7 parts, 9 parts of gelatin, hydroxypropyl methyl cellulose 13
Part.
Auxiliary material includes following composition by weight: plantain seed 5 parts, golden cypress 3 parts, 6 parts of the dried rhizome of rehmannia, the radix paeoniae rubrathe 5 parts, the red sage root 6 parts, the bighead atractylodes rhizome 9
Part, lotus nut 5 parts, 6 parts of Poria cocos, selfheal 9 parts, black nightshade 11 parts.
This capsule product is prepared by following steps:
The raw material needing is weighed according to certain component ratio and takes by S1: weigh proportioning；
S2: capsule shell raw material makes, and all puts into Arabic gum, gelatin and hydroxypropyl methyl cellulose in same equipment and carries out
Dissolution process, is loaded with water in this equipment, heats water to 88 degrees Celsius, and to the Arabic gum in this equipment, gelatin and hydroxyl
Propyl methocel is stirred, and the speed wherein stirring is 1200r/min；
The shaping of S3: capsule shell makes, and all measures the Arabic gum being stirred, gelatin and Gonak and pours into
Carrying out being cooled to capsule shell in mold for empty capsule standby, the temperature of cooling shaping is 48 degrees Celsius；
S4: auxiliary material solution makes, by plantain seed, golden cypress, the dried rhizome of rehmannia, the radix paeoniae rubrathe, the red sage root, white, lotus nut-, Poria cocos, selfheal, black nightshade
Putting in firing equipment together with water and heating, the time of heating is 34 hours, and the temperature of heating is 90 degrees Celsius, and to auxiliary
Material solution is stirred, speed 1000r/min of stirring；
S5: filtering auxiliary material, the auxiliary material after terminating heating transfers to filter in filter plant, by former for solid adjuvant material therein
Material removes, and preserves solution and uses；
S6: drug powder makes, and spreads out indole-3-carbinol, di-indole methyl hydride, indole-3-carbinol derivative and di-indole methyl hydride
Biology all puts in auxiliary material solution and stirs, during stirring a length of 45 minutes, and whipping temp is 99 degrees Celsius, obtains drug solution, will
Drug solution is transferred in evaporation equipment be evaporated crystallization, obtains medical solid, is ground medical solid, obtains medicine
Powder；
S7: capsule makes, and is uniformly positioned in the inner chamber of each capsule shell drug powder according to certain weight, capsule system
Complete.
Embodiment two
The present invention provides a kind of technical scheme: indole-3-carbinol, di-indole methyl hydride and derivative thereof are fertile at preparation treatment prostate
Application in big medicine.
This capsule product includes following composition by weight: indole-3-carbinol 12 parts, di-indole methyl hydride 7 parts, indole-3-carbinol
8 parts of derivative, diindolylmethane derivative 12 parts, 26 parts of Capsules preparation, auxiliary material 65 parts.
Capsules preparation includes following composition by weight: Arabic gum 6 parts, 8 parts of gelatin, hydroxypropyl methyl cellulose 12
Part.
Auxiliary material includes following composition by weight: plantain seed 4 parts, golden cypress 4 parts, 7 parts of the dried rhizome of rehmannia, the radix paeoniae rubrathe 6 parts, the red sage root 5 parts, the bighead atractylodes rhizome 8
Part, lotus nut 6 parts, 7 parts of Poria cocos, selfheal 8 parts, black nightshade 10 parts.
This capsule product is prepared by following steps:
The raw material needing is weighed according to certain component ratio and takes by S1: weigh proportioning；
S2: capsule shell raw material makes, and all puts into Arabic gum, gelatin and hydroxypropyl methyl cellulose in same equipment and carries out
Dissolution process, is loaded with water in this equipment, heats water to 99 degrees Celsius, and to the Arabic gum in this equipment, gelatin and hydroxyl
Propyl methocel is stirred, and the speed wherein stirring is 1100r/min；
The shaping of S3: capsule shell makes, and all measures the Arabic gum being stirred, gelatin and Gonak and pours into
Carrying out being cooled to capsule shell in mold for empty capsule standby, the temperature of cooling shaping is 32 degrees Celsius；
S4: auxiliary material solution makes, by plantain seed, golden cypress, the dried rhizome of rehmannia, the radix paeoniae rubrathe, the red sage root, white, lotus nut-, Poria cocos, selfheal, black nightshade
Putting in firing equipment together with water and heating, the time of heating is 30 hours, and the temperature of heating is 89 degrees Celsius, and to auxiliary
Material solution is stirred, and the speed of stirring is 900r/min；
S5: filtering auxiliary material, the auxiliary material after terminating heating transfers to filter in filter plant, by former for solid adjuvant material therein
Material removes, and preserves solution and uses；
S6: drug powder makes, and spreads out indole-3-carbinol, di-indole methyl hydride, indole-3-carbinol derivative and di-indole methyl hydride
Biology all puts in auxiliary material solution and stirs, during stirring a length of 50 minutes, and whipping temp is 103 degrees Celsius, obtains drug solution, will
Drug solution is transferred in evaporation equipment be evaporated crystallization, obtains medical solid, is ground medical solid, obtains medicine
Powder；
S7: capsule makes, and is uniformly positioned in the inner chamber of each capsule shell drug powder according to certain weight, capsule system
Complete.
By contrast experiment is carried out to above-mentioned two groups of embodiments, it can be found that, before two groups of embodiments all can be to patient
Row adenoncus plays certain result for the treatment of, and inventive formulation is simpler, and more scientific and reasonable, by adding Yin
Diindyl-3-methyl alcohol, di-indole methyl hydride and derivative thereof so that the state of an illness of prostate patient is suppressed relatively, mitigate prostate and suffer from
The misery of person；By plantain seed, golden cypress, the dried rhizome of rehmannia, the radix paeoniae rubrathe, the red sage root, white, lotus nut-, Poria cocos, selfheal, the ten taste medium-height grass such as black nightshade
Medicine, as auxiliary material, reaches the effect assisting indole-3-carbinol, di-indole methyl hydride and derivative thereof to treat prostate enlargement
Really, thus fundamentally treat prostate enlargement, long-term taking, make Rehabilitation.
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, permissible
Understand and multiple change, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention
And modification, the scope of the present invention be defined by the appended.
Claims (5)
1. indole-3-carbinol, di-indole methyl hydride and derivative thereof the application in preparation treatment hypertrophy of the prostate medicine.
2. the capsule product of indole-3-carbinol according to claim 1, di-indole methyl hydride and derivative thereof, its feature exists
In: this capsule product includes following composition by weight: indole-3-carbinol 9-14 part, di-indole methyl hydride 3-7 part, indole-3-carbinol spread out
Biological 4-9 part, diindolylmethane derivative 6-13 part, Capsules preparation 23-40 part, auxiliary material 30-90 part.
3. the capsule product of a kind of indole-3-carbinol according to claim 2, di-indole methyl hydride and derivative thereof, it is special
Levy and be: described Capsules preparation includes following composition by weight: Arabic gum 5-9 part, gelatin 7-12 part, hydroxypropyl methyl are fine
Dimension element 11-15 part.
4. the capsule product of a kind of indole-3-carbinol according to claim 2, di-indole methyl hydride and derivative thereof, it is special
Levy and be: described auxiliary material includes following composition by weight: plantain seed 3-7 part, golden cypress 2-5 part, dried rhizome of rehmannia 4-8 part, radix paeoniae rubrathe 3-6 part, pellet
Ginseng 4-9 part, bighead atractylodes rhizome 7-11 part, lotus nut 3-8 part, Poria cocos 5-9 part, selfheal 7-12 part, black nightshade 10-14 part.
5. the capsule of a kind of indole-3-carbinol described in 2 or 3 or 4, di-indole methyl hydride and derivative thereof is required according to claim
Goods, it is characterised in that: this capsule product is prepared by following steps:
Required raw material is weighed according to certain component ratio and takes by S1: weigh proportioning；
S2: capsule shell raw material makes, and all puts into Arabic gum, gelatin and hydroxypropyl methyl cellulose in same equipment and carries out
Dissolution process, is loaded with water in this equipment, heats water to 70-109 degree Celsius, and to the Arabic gum in this equipment, gelatin
Being stirred with hydroxypropyl methyl cellulose, the speed wherein stirring is 1000-1700r/min；
The shaping of S3: capsule shell makes, and all measures the Arabic gum being stirred, gelatin and Gonak and pours into
Carrying out being cooled to capsule shell in mold for empty capsule standby, the temperature of cooling shaping is 10-51 degree Celsius；
S4: auxiliary material solution makes, by plantain seed, golden cypress, the dried rhizome of rehmannia, the radix paeoniae rubrathe, the red sage root, white, lotus nut-, Poria cocos, selfheal, black nightshade
Putting in firing equipment together with water and heating, the time of heating is 24-48 hour, and the temperature of heating is that 88-114 is Celsius
Degree, and auxiliary material solution is stirred, the speed of stirring is 800-1200r/min；
S5: filtering auxiliary material, the auxiliary material after terminating heating transfers to filter in filter plant, by former for solid adjuvant material therein
Material removes, and preserves solution and uses；
S6: drug powder makes, and spreads out indole-3-carbinol, di-indole methyl hydride, indole-3-carbinol derivative and di-indole methyl hydride
Biology all puts in auxiliary material solution and stirs, and a length of 30-70 minute during stirring, whipping temp is 80-114 degree Celsius, obtains medicine
Drug solution is transferred in evaporation equipment be evaporated crystallization, obtains medical solid, be ground medical solid by solution,
Obtain drug powder；
S7: capsule makes, and is uniformly positioned in the inner chamber of each capsule shell drug powder according to certain weight, capsule system
Complete.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610433542.7A CN106074504A (en) | 2016-06-18 | 2016-06-18 | The application in preparation treatment hypertrophy of the prostate medicine of indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610433542.7A CN106074504A (en) | 2016-06-18 | 2016-06-18 | The application in preparation treatment hypertrophy of the prostate medicine of indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof |
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| CN106074504A true CN106074504A (en) | 2016-11-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610433542.7A Pending CN106074504A (en) | 2016-06-18 | 2016-06-18 | The application in preparation treatment hypertrophy of the prostate medicine of indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265643A (en) * | 2016-08-11 | 2017-01-04 | 安徽四正医药科技有限公司 | The application in preparation treatment prostate hyperplasia medicine of indole 3 methanol, di-indole methyl hydride and derivant thereof |
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| CN101700343A (en) * | 2009-11-19 | 2010-05-05 | 张晓玲 | Traditional Chinese medicine for treating prostatitis |
| CN101940568A (en) * | 2010-08-17 | 2011-01-12 | 合肥博太医药生物技术发展有限公司 | Application of indole-3-methanol, diindolylmethane and derivatives thereof in preparing medicament for treating cardiac failure caused by anthracycline |
| CN102335168A (en) * | 2011-10-25 | 2012-02-01 | 合肥博太医药生物技术发展有限公司 | Application of indole-3-carbinol, diindolyl methane and derivatives thereof in preparation of medicaments for treating osteoporosis |
| CN104524106A (en) * | 2014-12-22 | 2015-04-22 | 广东聚智诚科技有限公司 | Traditional Chinese medicine preparation for treating prostatitis and prostatic hyperplasia and preparation method thereof |
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2016
- 2016-06-18 CN CN201610433542.7A patent/CN106074504A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101700343A (en) * | 2009-11-19 | 2010-05-05 | 张晓玲 | Traditional Chinese medicine for treating prostatitis |
| CN101940568A (en) * | 2010-08-17 | 2011-01-12 | 合肥博太医药生物技术发展有限公司 | Application of indole-3-methanol, diindolylmethane and derivatives thereof in preparing medicament for treating cardiac failure caused by anthracycline |
| CN102335168A (en) * | 2011-10-25 | 2012-02-01 | 合肥博太医药生物技术发展有限公司 | Application of indole-3-carbinol, diindolyl methane and derivatives thereof in preparation of medicaments for treating osteoporosis |
| CN104524106A (en) * | 2014-12-22 | 2015-04-22 | 广东聚智诚科技有限公司 | Traditional Chinese medicine preparation for treating prostatitis and prostatic hyperplasia and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265643A (en) * | 2016-08-11 | 2017-01-04 | 安徽四正医药科技有限公司 | The application in preparation treatment prostate hyperplasia medicine of indole 3 methanol, di-indole methyl hydride and derivant thereof |
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Application publication date: 20161109 |